TDR Targets

Basic information

Technical information

TDR Targets ID: 150599
Name: 7-[3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1 -yl]propylamino]-N,N-dimethyl-1H-pyrazolo[1,5 -a]pyrimidin-8-ium-6-carboxamide
MW: 456.536 | Formula: C23H31FN7O2+
H donors: 2 H acceptors: 2 LogP: 2.89 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(F)ccc1N1CCN(CC1)CCCNc1c(c[nH]c2[n+]1ncc2)C(=O)N(C)C
InChi: 1S/C23H30FN7O2/c1-28(2)23(32)18-16-26-21-7-9-27-31(21)22(18)25-8-4-10-29-11-13-30(14-12-29)19-6-5-17(24)15-20(19)33-3/h5-7,9,15-16H,4,8,10-14H2,1-3H3,(H,25,26,27,32)/p+1
InChiKey: LGXAYBNNXNQCIM-UHFFFAOYSA-O

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

7-[3-[4-(4-fluoro-2-methoxy-phenyl)piperazin-1-yl]propylamino]-N,N-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-8-ium-6-carboxamide
7-[3-[4-(4-fluoro-2-methoxyphenyl)-1-piperazinyl]propylamino]-N,N-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-8-ium-6-carboxamide
7-[3-[4-(4-fluoro-2-methoxy-phenyl)piperazino]propylamino]-N,N-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-8-ium-6-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Alpha-1d adrenergic receptor	Starlite/ChEMBL	References
Oryctolagus cuniculus	Alpha-1a adrenergic receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	amine GPCR	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma japonicum	Alpha-1D adrenergic receptor, putative	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Get druggable targets OG5_128924	All targets in OG5_128924

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Alpha-1a adrenergic receptor	466 aa	395 aa	31.1 %
Echinococcus multilocularis	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	396 aa	21.7 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	397 aa	20.9 %
Echinococcus granulosus	biogenic amine 5HT receptor	Alpha-1a adrenergic receptor	466 aa	416 aa	32.0 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	415 aa	21.4 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Alpha-1a adrenergic receptor	466 aa	446 aa	30.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.3597	0.3597
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.1062	0.1062
Onchocerca volvulus		0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Brugia malayi	kettin	0.0039	0.1062	0.2954
Schistosoma mansoni	titin	0.0039	0.1062	0.1062
Echinococcus multilocularis	anosmin 1	0.0047	0.1502	0.4177
Echinococcus granulosus	Netrin receptor DCC	0.0047	0.1502	0.4177
Schistosoma mansoni	titin	0.0086	0.3597	0.3597
Schistosoma mansoni	cell adhesion molecule	0.0086	0.3597	0.3597
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0047	0.1502	0.4177
Echinococcus multilocularis	Netrin receptor DCC	0.0047	0.1502	0.4177
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Schistosoma mansoni	slit	0.0039	0.1062	0.1062
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0086	0.3597	1
Echinococcus granulosus	anosmin 1	0.0047	0.1502	0.4177
Echinococcus multilocularis	Fibronectin, type III	0.0047	0.1502	0.4177
Loa Loa (eye worm)	animal heme peroxidase	0.0039	0.1062	0.2954
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0023	0.0218	0.0607
Brugia malayi	Disorganized muscle protein 1	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0086	0.3597	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Schistosoma mansoni	titin	0.0039	0.1062	0.1062
Schistosoma mansoni	tyrosine kinase	0.0023	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Brugia malayi	myotactin form B	0.0047	0.1502	0.4177
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0047	0.1502	0.4177
Schistosoma mansoni	hypothetical protein	0.0039	0.1062	0.1062
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Schistosoma mansoni	hypothetical protein	0.0039	0.1062	0.1062
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0047	0.1502	0.1502
Echinococcus multilocularis		0.0039	0.1062	0.2954
Schistosoma mansoni	hypothetical protein	0.0039	0.1062	0.1062
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0039	0.1062	0.2954
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0023	0.0218	0.0607
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0047	0.1502	0.4177
Brugia malayi	SRC-1	0.0023	0.0218	0.0607
Echinococcus multilocularis	usherin	0.0047	0.1502	0.4177
Schistosoma mansoni	nephrin related	0.0039	0.1062	0.1062
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0047	0.1502	0.5
Onchocerca volvulus		0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Loa Loa (eye worm)	one IG domain family member	0.0039	0.1062	0.2954
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0039	0.1062	0.2954
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	titin	0.0039	0.1062	0.2954
Echinococcus granulosus	usherin	0.0047	0.1502	0.4177
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0023	0.0218	0.0607
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0047	0.1502	0.4177
Echinococcus granulosus	Netrin receptor DCC	0.0047	0.1502	0.4177
Trypanosoma cruzi	hypothetical protein, conserved	0.0047	0.1502	0.5
Echinococcus multilocularis	tyrosine protein kinase otk	0.0039	0.1062	0.2954
Echinococcus granulosus	titin	0.0086	0.3597	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0023	0.0218	0.0607
Echinococcus multilocularis	titin	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0039	0.1062	0.2954
Schistosoma mansoni	cell adhesion molecule	0.0086	0.3597	0.3597
Onchocerca volvulus		0.0047	0.1502	0.4177
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0023	0.0218	0.0607
Brugia malayi	Prion-like-	0.0039	0.1062	0.2954
Echinococcus granulosus	lachesin	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Brugia malayi	Tyrosine-protein kinase abl-1	0.0023	0.0218	0.0607
Echinococcus multilocularis	transfer RNA-Phe	0.0086	0.3597	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Brugia malayi	hypothetical protein	0.0047	0.1502	0.4177
Schistosoma mansoni	tyrosine kinase	0.0023	0.0218	0.0218
Leishmania major	hypothetical protein, conserved	0.0047	0.1502	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0062	0.2311	0.6424
Echinococcus multilocularis	anosmin 1	0.0047	0.1502	0.4177
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0086	0.3597	1
Brugia malayi	myotactin form A	0.0047	0.1502	0.4177
Schistosoma mansoni	protein tyrosine phosphatase	0.0047	0.1502	0.1502
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0023	0.0218	0.0607
Loa Loa (eye worm)	UNCoordinated family member	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0023	0.0218	0.0607
Schistosoma mansoni	myosin-binding protein-related	0.0086	0.3597	0.3597
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0047	0.1502	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0047	0.1502	0.4177
Schistosoma mansoni	factor for adipocyte differentiation	0.0047	0.1502	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Onchocerca volvulus		0.0047	0.1502	0.4177
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0023	0.0218	0.0607
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Echinococcus multilocularis	hemicentin 1	0.0039	0.1062	0.2954
Loa Loa (eye worm)	CAMK protein kinase	0.0086	0.3597	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Schistosoma mansoni	nephrin	0.0086	0.3597	0.3597
Echinococcus multilocularis	twitchin	0.0039	0.1062	0.2954
Echinococcus granulosus	roundabout 2	0.0086	0.3597	1
Schistosoma mansoni	hypothetical protein	0.0039	0.1062	0.1062
Brugia malayi	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Schistosoma mansoni	tyrosine kinase	0.0023	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0086	0.3597	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0047	0.1502	0.4177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Schistosoma mansoni	hypothetical protein	0.0039	0.1062	0.1062
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.1062	0.2954
Echinococcus granulosus	contactin	0.0086	0.3597	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0047	0.1502	0.4177
Brugia malayi	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0039	0.1062	0.2954
Onchocerca volvulus		0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0086	0.3597	0.3597
Loa Loa (eye worm)	myotactin form A	0.0047	0.1502	0.4177
Schistosoma mansoni	tyrosine kinase	0.0054	0.1871	0.1871
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0023	0.0218	0.0607
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Schistosoma mansoni	cell adhesion molecule	0.0047	0.1502	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Schistosoma mansoni	titin	0.0039	0.1062	0.1062
Schistosoma mansoni	cell adhesion molecule	0.0086	0.3597	0.3597
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0086	0.3597	1
Brugia malayi	hypothetical protein	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0039	0.1062	0.1062
Echinococcus granulosus	titin	0.0086	0.3597	1
Schistosoma mansoni	neuroglian	0.0086	0.3597	0.3597
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus granulosus	twitchin	0.0039	0.1062	0.2954
Echinococcus granulosus	EG95	0.0047	0.1502	0.4177
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0047	0.1502	0.1502
Schistosoma mansoni	factor for adipocyte differentiation	0.0047	0.1502	0.1502
Loa Loa (eye worm)	TK/ROR protein kinase	0.0054	0.1871	0.52
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Brugia malayi	protein unc-22	0.0086	0.3597	1
Brugia malayi	Protein-tyrosine phosphatase	0.0047	0.1502	0.4177
Echinococcus granulosus	titin	0.0039	0.1062	0.2954
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0047	0.1502	0.4177
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0086	0.3597	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0023	0.0218	0.0607
Echinococcus granulosus	titin	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Schistosoma mansoni	hypothetical protein	0.0047	0.1502	0.1502
Brugia malayi	Animal haem peroxidase family protein	0.0039	0.1062	0.2954
Echinococcus granulosus	insulin growth factor binding	0.0039	0.1062	0.2954
Echinococcus granulosus	neuroglian	0.0039	0.1062	0.2954
Loa Loa (eye worm)	TK protein kinase	0.0054	0.1871	0.52
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0023	0.0218	0.0607
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0039	0.1062	0.2954
Onchocerca volvulus		0.0039	0.1062	0.2954
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0039	0.1062	0.2954
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0047	0.1502	0.4177
Brugia malayi	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Schistosoma mansoni	cell adhesion molecule	0.0039	0.1062	0.1062
Echinococcus granulosus	down syndrome cell adhesion	0.0039	0.1062	0.2954
Echinococcus granulosus	G1Y162 protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Brugia malayi	SPRY domain containing protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0086	0.3597	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0086	0.3597	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0023	0.0218	0.0607
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0086	0.3597	1
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0039	0.1062	0.2954
Echinococcus granulosus	cell adhesion molecule	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	lachesin	0.0039	0.1062	0.2954
Echinococcus multilocularis	titin	0.0086	0.3597	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Schistosoma mansoni	titin	0.0047	0.1502	0.1502
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0086	0.3597	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0047	0.1502	0.4177
Loa Loa (eye worm)	lethal protein 805	0.0047	0.1502	0.4177
Echinococcus multilocularis	neuroglian	0.0086	0.3597	1
Onchocerca volvulus		0.0086	0.3597	1
Brugia malayi	Leucine Rich Repeat family protein	0.0039	0.1062	0.2954
Echinococcus granulosus	tyrosine protein kinase otk	0.0039	0.1062	0.2954
Brugia malayi	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	roundabout 2	0.0086	0.3597	1
Schistosoma mansoni	titin	0.0039	0.1062	0.1062
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0047	0.1502	0.4177
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0062	0.2311	0.6424
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0023	0.0218	0.0607
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0047	0.1502	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0019	0	0.5
Echinococcus multilocularis	anosmin 1	0.0047	0.1502	0.4177
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0023	0.0218	0.0607
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Onchocerca volvulus	Peroxidasin homolog	0.0039	0.1062	0.2954
Onchocerca volvulus		0.0047	0.1502	0.4177
Schistosoma mansoni	cell adhesion molecule	0.0039	0.1062	0.1062
Echinococcus multilocularis	hemicentin 1	0.0039	0.1062	0.2954
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0086	0.3597	1
Brugia malayi	Prion-like-	0.0039	0.1062	0.2954
Echinococcus multilocularis	roundabout 2	0.0086	0.3597	1
Schistosoma mansoni	septate junction protein	0.0039	0.1062	0.1062
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0039	0.1062	0.2954
Schistosoma mansoni	hemicentin	0.0086	0.3597	0.3597
Onchocerca volvulus		0.0039	0.1062	0.2954
Echinococcus granulosus	roundabout 2	0.0086	0.3597	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0023	0.0218	0.0607
Schistosoma mansoni	septate junction protein	0.0039	0.1062	0.1062
Schistosoma mansoni	ephrin receptor	0.0062	0.2311	0.2311
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus granulosus	hemicentin 1	0.0039	0.1062	0.2954
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0047	0.1502	0.4177
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0047	0.1502	0.4177
Schistosoma mansoni	factor for adipocyte differentiation	0.0047	0.1502	0.1502
Echinococcus granulosus	Fibronectin type III	0.0047	0.1502	0.4177
Echinococcus multilocularis	Netrin receptor DCC	0.0047	0.1502	0.4177
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0054	0.1871	0.52
Brugia malayi	Prion-like-	0.0039	0.1062	0.2954
Echinococcus multilocularis	roundabout 2	0.0086	0.3597	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0023	0.0218	0.0607
Loa Loa (eye worm)	SRC-1	0.0023	0.0218	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0086	0.3597	1
Echinococcus granulosus	nephrin	0.0086	0.3597	1
Echinococcus multilocularis	titin	0.0047	0.1502	0.4177
Echinococcus multilocularis	insulin growth factor binding	0.0039	0.1062	0.2954
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0023	0.0218	0.0607
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0054	0.1871	0.52
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Echinococcus multilocularis	down syndrome cell adhesion	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Onchocerca volvulus		0.0047	0.1502	0.4177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0047	0.1502	0.4177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.3597	1
Onchocerca volvulus	Peroxidasin homolog	0.0039	0.1062	0.2954
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0086	0.3597	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Schistosoma mansoni	nephrin	0.0086	0.3597	0.3597
Echinococcus granulosus	peroxidasin	0.0039	0.1062	0.2954
Echinococcus multilocularis	cell adhesion molecule	0.0047	0.1502	0.4177
Schistosoma mansoni	titin	0.0039	0.1062	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0047	0.1502	0.4177
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0023	0.0218	0.0607
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Schistosoma mansoni	tripartite motif protein trim9	0.0047	0.1502	0.1502
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0047	0.1502	0.4177
Echinococcus multilocularis	peroxidasin	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0047	0.1502	0.4177
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.1062	0.2954
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0023	0.0218	0.0607
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Schistosoma mansoni	titin	0.0039	0.1062	0.1062
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0039	0.1062	0.1062
Echinococcus granulosus	titin	0.0039	0.1062	0.2954
Onchocerca volvulus		0.0047	0.1502	0.4177
Onchocerca volvulus	Putative titin	0.0039	0.1062	0.2954
Schistosoma mansoni	tyrosine kinase	0.0023	0.0218	0.0218
Echinococcus granulosus	neuroglian	0.0086	0.3597	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0086	0.3597	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0023	0.0218	0.0218
Echinococcus granulosus	roundabout 2	0.0086	0.3597	1
Brugia malayi	Lethal protein 805	0.0047	0.1502	0.4177
Loa Loa (eye worm)	disorganized muscle protein 1	0.0039	0.1062	0.2954
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0047	0.1502	0.1502
Onchocerca volvulus		0.0039	0.1062	0.2954
Brugia malayi	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0039	0.1062	0.2954
Brugia malayi	Peroxidasin	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0047	0.1502	0.4177
Schistosoma mansoni	roundabout	0.0039	0.1062	0.1062
Schistosoma mansoni	cell adhesion molecule	0.0086	0.3597	0.3597
Schistosoma mansoni	hypothetical protein	0.0047	0.1502	0.1502
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0054	0.1871	0.52
Onchocerca volvulus		0.0039	0.1062	0.2954
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0039	0.1062	0.2954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Schistosoma mansoni	titin	0.0086	0.3597	0.3597
Onchocerca volvulus	Tyrosine kinase homolog	0.0054	0.1871	0.52
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0047	0.1502	0.1502
Brugia malayi	Lethal protein 805	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Onchocerca volvulus		0.0047	0.1502	0.4177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	c src tyrosine kinase	0.0023	0.0218	0.0607
Schistosoma mansoni	hypothetical protein	0.0039	0.1062	0.1062
Brugia malayi	Prion-like-	0.0039	0.1062	0.2954
Echinococcus granulosus	anosmin 1	0.0047	0.1502	0.4177
Loa Loa (eye worm)	projectin	0.0086	0.3597	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0086	0.3597	1
Echinococcus granulosus	anosmin 1	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0047	0.1502	0.4177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0047	0.1502	0.4177
Echinococcus multilocularis	neuroglian	0.0039	0.1062	0.2954
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0047	0.1502	0.4177
Onchocerca volvulus		0.0047	0.1502	0.4177
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0023	0.0218	0.0607
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Echinococcus multilocularis	titin	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0086	0.3597	1
Onchocerca volvulus	Netrin receptor homolog	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1062	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.1062	0.2954
Echinococcus granulosus	c src tyrosine kinase	0.0023	0.0218	0.0607
Brugia malayi	Fibronectin type III domain containing protein	0.0047	0.1502	0.4177
Schistosoma mansoni	hypothetical protein	0.0086	0.3597	0.3597
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1502	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0086	0.3597	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (functional)	= 7	Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor	ChEMBL.	9276013
Kd (functional)	= 9.2	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL.	9276013
pA2 (functional)	= 7	Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor	ChEMBL.	9276013
pA2 (functional)	= 9.2	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL.	9276013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL91547
PubChem: 10647512

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 150599