Detailed information for compound 1518663

Basic information

Technical information
  • TDR Targets ID: 1518663
  • Name: [1-[(2-fluorophenyl)methyl]piperidin-3-yl]-py rrolidin-1-ylmethanone; oxalic acid
  • MW: 380.411 | Formula: C19H25FN2O5
  • H donors: 2 H acceptors: 5 LogP: -0.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC1)C1CCCN(C1)Cc1ccccc1F.OC(=O)C(=O)O
  • InChi: 1S/C17H23FN2O.C2H2O4/c18-16-8-2-1-6-14(16)12-19-9-5-7-15(13-19)17(21)20-10-3-4-11-20;3-1(4)2(5)6/h1-2,6,8,15H,3-5,7,9-13H2;(H,3,4)(H,5,6)
  • InChiKey: CHZBZFDJWQRAJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-[(2-fluorophenyl)methyl]-3-piperidyl]-pyrrolidin-1-yl-methanone; oxalic acid
  • [1-[(2-fluorophenyl)methyl]-3-piperidinyl]-1-pyrrolidinylmethanone; oxalic acid
  • [1-(2-fluorobenzyl)-3-piperidyl]-pyrrolidin-1-yl-methanone; oxalic acid
  • ethanedioic acid; [1-[(2-fluorophenyl)methyl]piperidin-3-yl]-pyrrolidin-1-yl-methanone
  • 1-(2-fluorobenzyl)-3-(1-pyrrolidinylcarbonyl)piperidine oxalate
  • MLS000974846
  • SMR000497541

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.061 0.2287
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.1055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0045 0.0107
Trichomonas vaginalis chromobox protein, putative 0.0084 0.061 0.2001
Schistosoma mansoni vam6/vps39 related 0.0052 0.0323 0.0309
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0166 0.1332 0.1332
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0015 0.0063
Loa Loa (eye worm) carboxylesterase 0.0065 0.0444 0.1666
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Brugia malayi Bromodomain containing protein 0.0092 0.0682 0.3246
Echinococcus multilocularis dna polymerase kappa 0.0023 0.007 0.007
Onchocerca volvulus 0.0287 0.2405 1
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0143 0.1134 0.1134
Toxoplasma gondii cell division protein CDC48CY 0.0143 0.1134 1
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0078 0.0368
Echinococcus multilocularis RUN 0.0202 0.1654 0.1654
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.007 0.002
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0052 0.0323 0.0309
Brugia malayi CXXC zinc finger family protein 0.003 0.0127 0.0598
Brugia malayi hypothetical protein 0.0053 0.033 0.157
Schistosoma mansoni sphingosine kinase A B 0.0316 0.2661 0.265
Brugia malayi hypothetical protein 0.0202 0.1654 0.7886
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.157
Echinococcus multilocularis protein jagged 1 0.0017 0.0015 0.0015
Echinococcus granulosus lipoxygenase domain containing protein 0.0202 0.1654 0.1654
Onchocerca volvulus Peroxidasin homolog 0.0053 0.033 0.1321
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0025 0.0085 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Loa Loa (eye worm) hypothetical protein 0.0175 0.1417 0.5322
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0018
Echinococcus granulosus fibropellin Ia 0.0017 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.007 0.03
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0136 0.1069 0.1056
Echinococcus granulosus chromobox protein 1 0.0084 0.061 0.061
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0015 0.0063
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.007 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0107
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0314 0.1008
Schistosoma mansoni hypothetical protein 0.0041 0.0229 0.0214
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.012 0.012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.033 0.1321
Brugia malayi Bromodomain containing protein 0.0046 0.0274 0.13
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Echinococcus granulosus neural cadherin 0.0017 0.0015 0.0015
Echinococcus multilocularis dna polymerase eta 0.0023 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Mycobacterium ulcerans hypothetical protein 0.003 0.0126 0.0235
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0314 0.1008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Giardia lamblia PHD finger protein 15 0.0035 0.0176 0.0542
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2405 0.8029
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0053 0.0337 0.0337
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0053 0.0337 0.1263
Plasmodium vivax SET domain protein, putative 0.0037 0.0189 0.078
Leishmania major hypothetical protein, conserved 0.0257 0.2141 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.033 0.1237
Loa Loa (eye worm) hypothetical protein 0.0316 0.2661 1
Brugia malayi notch-like transmembrane receptor 0.0017 0.0015 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0433 0.0419
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.007 0.03
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0059 0.0389 0.0375
Echinococcus multilocularis protein jagged 2 0.0017 0.0015 0.0015
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1237
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0282 0.0901
Loa Loa (eye worm) hypothetical protein 0.0085 0.0621 0.233
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0229 0.1085
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.007 0.03
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0189 0.1559
Toxoplasma gondii cell division protein CDC48AP 0.0086 0.0624 0.5444
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1237
Brugia malayi Delta serrate ligand family protein 0.0017 0.0015 0.0063
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0187 0.1521 0.1521
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2992 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.007 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0033 0.0118
Onchocerca volvulus 0.005 0.0311 0.1241
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.0033
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1392 0.5
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0086 0.0624 0.5444
Brugia malayi Protein kinase domain containing protein 0.0053 0.0337 0.1602
Onchocerca volvulus Peroxidasin homolog 0.0053 0.033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0136 0.1069 0.6316
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0085 0.0314
Brugia malayi probable protein kinase 0.0177 0.1431 0.682
Schistosoma mansoni cpg binding protein 0.0034 0.0162 0.0148
Schistosoma mansoni ap endonuclease 0.0023 0.0065 0.0051
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2992 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0052 0.0323 0.0309
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0065 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0046 0.0032
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0052 0.0323 0.1398
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0065 0.0173
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.2141 1
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.2141 1
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.157
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0045 0.0107
Entamoeba histolytica cdc48-like protein, putative 0.0136 0.1069 0.3429
Mycobacterium ulcerans hypothetical protein 0.0316 0.2661 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0143 0.1134 0.1121
Onchocerca volvulus 0.0053 0.033 0.1321
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0143 0.1134 0.3762
Loa Loa (eye worm) hypothetical protein 0.0052 0.0323 0.121
Schistosoma mansoni chromobox protein 0.0084 0.061 0.0596
Loa Loa (eye worm) hypothetical protein 0.0065 0.0444 0.1666
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0176 0.1441
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0126 0.0235
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0015 0.0015
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0052 0.0323 0.1484
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0176 0.0176
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.007 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.007 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0189 0.0175
Loa Loa (eye worm) hypothetical protein 0.006 0.0397 0.149
Brugia malayi chromobox protein homolog 3 0.0047 0.0282 0.1339
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0337 0.0323
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0126 0.0235
Schistosoma mansoni lipoxygenase 0.1144 1 1
Brugia malayi EGF-like domain containing protein 0.0017 0.0015 0.0063
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0176 0.0162
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0015 0.0015
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0126 0.0235
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.007 0.0056
Loa Loa (eye worm) vesicle-fusing ATPase 0.0084 0.0609 0.2285
Brugia malayi Muscle positioning protein 4 0.0017 0.0015 0.0063
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0065 0.0065
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0508 0.1906
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0518 0.0518
Brugia malayi Pre-SET motif family protein 0.0252 0.2097 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0065 0.0173
Loa Loa (eye worm) hypothetical protein 0.0202 0.1654 0.6216
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0052 0.0323 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0372 0.0358
Mycobacterium tuberculosis Conserved protein 0.0316 0.2661 1
Brugia malayi map kinase activated protein kinase protein 2 0.0187 0.1521 0.7253
Echinococcus granulosus Polycystic kidney disease protein 0.0202 0.1654 0.1654
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0176 0.0697
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.0021 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0397 0.149
Onchocerca volvulus 0.0037 0.0192 0.074
Brugia malayi hypothetical protein 0.0202 0.1654 0.7886
Brugia malayi valosin containing protein 0.0084 0.0609 0.2899
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0282 0.1118
Echinococcus granulosus protein jagged 2 0.0017 0.0015 0.0015
Schistosoma mansoni peroxidasin 0.0053 0.033 0.0316
Echinococcus granulosus GPCR family 2 0.0019 0.0033 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0397 0.189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.007 0.0203
Onchocerca volvulus Alhambra homolog 0.0035 0.0176 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0202 0.1654 0.6216
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0277 0.0263
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0052 0.0323 0.1398
Brugia malayi Blistered cuticle protein 3 0.0053 0.033 0.157
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0059 0.0389 0.1851
Onchocerca volvulus 0.003 0.0127 0.0469
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.2141 1
Schistosoma mansoni hypothetical protein 0.0422 0.3606 0.3597
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0176 0.0176
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Brugia malayi Heterochromatin protein 1 0.0084 0.061 0.2902
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0015 0.0015
Onchocerca volvulus 0.0202 0.1654 0.6859
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0046 0.0046
Brugia malayi EGF-like domain containing protein 0.0017 0.0015 0.0063
Echinococcus multilocularis slit 2 protein 0.0017 0.0015 0.0015
Echinococcus multilocularis protein jagged 1 0.0017 0.0015 0.0015
Brugia malayi Bromodomain containing protein 0.0038 0.0201 0.0954
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.0013
Schistosoma mansoni lipoxygenase 0.078 0.6777 0.6772
Toxoplasma gondii exonuclease III APE 0.0023 0.0065 0.0452
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0176 0.0657
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0015 0.000000055988
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Trypanosoma brucei unspecified product 0.0023 0.007 0.03
Brugia malayi Cadherin domain containing protein 0.0017 0.0015 0.0063
Echinococcus multilocularis peregrin 0.0038 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0084 0.0609 0.2285
Loa Loa (eye worm) hypothetical protein 0.0046 0.0275 0.1028
Schistosoma mansoni sphingoid long chain base kinase 0.0316 0.2661 0.265
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0021 0.0075
Echinococcus granulosus RUN 0.0202 0.1654 0.1654
Echinococcus granulosus acetylcholinesterase 0.0065 0.0444 0.0444
Brugia malayi Carboxylesterase family protein 0.0065 0.0444 0.2114
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0518 0.0518
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.6178 0.6173
Onchocerca volvulus 0.0053 0.033 0.1321
Echinococcus granulosus protein jagged 2 0.0017 0.0015 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.007 0.0203
Echinococcus multilocularis peroxidasin 0.0053 0.033 0.033
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0166 0.1332 0.5511
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0053 0.0337 0.0337
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0444 0.0444
Schistosoma mansoni polycystin 1-related 0.0202 0.1654 0.1642
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0166 0.1332 0.5004
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1237
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0034 0.0164 0.0506
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0176 0.1441
Echinococcus multilocularis Polycystic kidney disease protein 0.0202 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.007 0.026
Loa Loa (eye worm) hypothetical protein 0.0052 0.0323 0.121
Giardia lamblia AAA family ATPase 0.0086 0.0624 0.2047
Echinococcus multilocularis notch 0.0017 0.0015 0.0015
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0015 0.000000055988
Onchocerca volvulus 0.0052 0.0323 0.1291
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0126 0.0466
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0033 0.015
Echinococcus multilocularis GPCR, family 2 0.0019 0.0033 0.0033
Brugia malayi EGF-like domain containing protein 0.0017 0.0015 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.007 0.0203
Brugia malayi Cadherin domain containing protein 0.0017 0.0015 0.0063
Echinococcus granulosus cpg binding protein 0.0034 0.0162 0.0162
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0397 0.189
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Plasmodium vivax cell division cycle ATPase, putative 0.0052 0.0324 0.1628
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0018
Onchocerca volvulus 0.0053 0.033 0.1321
Brugia malayi Protein kinase domain containing protein 0.0166 0.1332 0.6349
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Brugia malayi Peroxidasin 0.0053 0.033 0.157
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1521 0.1509
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.012 0.0106
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.026
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.007 0.033
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0018
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0125 0.0972 0.3648
Echinococcus multilocularis cpg binding protein 0.0034 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.016 0.0491
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Echinococcus granulosus dnaJ subfamily B 0.0422 0.3606 0.3606
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0189 0.0189
Echinococcus multilocularis lipoxygenase domain containing protein 0.0202 0.1654 0.1654
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0399 0.3432
Plasmodium falciparum LCCL domain-containing protein 0.0202 0.1654 1
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1237
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0059 0.0389 0.0389
Brugia malayi PHD-finger family protein 0.0035 0.0176 0.0833
Brugia malayi EGF-like domain containing protein 0.0017 0.0015 0.0063
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0034 0.0164 0.0506
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1144 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0033 0.0033
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0444 0.1666
Echinococcus granulosus acetylcholinesterase 0.0065 0.0444 0.0444
Mycobacterium ulcerans hypothetical protein 0.003 0.0126 0.0235
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0187 0.1521 0.1521
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0277 0.1037
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2992 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.007 0.0203
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0015 0.0015
Echinococcus multilocularis 0.0125 0.0972 0.0972
Brugia malayi SET domain containing protein 0.0016 0.0003 0.001
Schistosoma mansoni peroxidasin 0.0053 0.033 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0015 0.0063
Echinococcus granulosus protein jagged 1 0.0017 0.0015 0.0015
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0298 0.0298
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0126 0.0126
Brugia malayi EGF-like domain containing protein 0.0017 0.0015 0.0063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.007 0.007
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0126 0.0235
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0046 0.0032
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.007 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0065 0.017
Schistosoma mansoni loxhd1 0.0202 0.1654 0.1642
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0053 0.0337 0.0337
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2097 0.7881
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0136 0.1069 0.4927
Schistosoma mansoni rab6-interacting 0.0202 0.1654 0.1642
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0444 0.043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0444 0.0444
Schistosoma mansoni zinc finger protein 0.0025 0.0088 0.0074
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0015 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.007 0.002
Echinococcus granulosus slit 2 protein 0.0017 0.0015 0.0015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0065 0.024
Brugia malayi EGF-like domain containing protein 0.0017 0.0015 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Echinococcus granulosus protein kinase 0.0125 0.0972 0.0972
Echinococcus multilocularis fibropellin Ia 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0166 0.1332 0.6349
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0118
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0065 0.0065
Brugia malayi Temporarily assigned gene name protein 59 0.0052 0.0323 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0282 0.0901
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0107
Echinococcus granulosus zinc finger protein 0.0025 0.0088 0.0088
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0065 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0065 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Loa Loa (eye worm) hypothetical protein 0.0052 0.0323 0.121
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.3606 0.3606
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2992 1
Brugia malayi PHD-finger family protein 0.0032 0.0145 0.0688
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Echinococcus granulosus chromobox protein 1 0.0084 0.061 0.061
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0372 0.0372
Loa Loa (eye worm) notch protein 0.0017 0.0015 0.005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.007 0.0203
Brugia malayi vesicle-fusing ATPase 0.0084 0.0609 0.2899
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0053 0.0337 0.0337
Echinococcus granulosus peregrin 0.0038 0.0201 0.0201
Onchocerca volvulus Peroxidase homolog 0.0053 0.033 0.1321
Schistosoma mansoni ap endonuclease 0.0023 0.0065 0.0051
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0015 0.0015
Echinococcus granulosus sphingosine kinase 1 0.0316 0.2661 0.2661
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.0716
Echinococcus granulosus delta-like protein 1 0.0017 0.0015 0.0015
Brugia malayi Pre-SET motif family protein 0.0037 0.0189 0.0896
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Echinococcus granulosus protein jagged 1 0.0017 0.0015 0.0015
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0143 0.1134 0.1134
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0053 0.0337 0.0337
Schistosoma mansoni rap gtpase-activating protein 0.0052 0.0323 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Schistosoma mansoni hypothetical protein 0.0035 0.0176 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.1123
Loa Loa (eye worm) hypothetical protein 0.0053 0.0335 0.1256
Schistosoma mansoni bromodomain containing protein 0.0078 0.0556 0.0542
Echinococcus granulosus notch 0.0017 0.0015 0.0015
Mycobacterium ulcerans ATPase 0.0086 0.0624 0.2154
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0277 0.0263
Entamoeba histolytica hypothetical protein, conserved 0.0316 0.2661 0.8867
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.012 0.012
Schistosoma mansoni protein kinase 0.0053 0.0337 0.0323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.007 0.0203
Plasmodium vivax multidomain scavenger receptor, putative 0.0202 0.1654 1
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0676 0.0662
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0143 0.1134 0.4684
Schistosoma mansoni chromobox protein 0.0084 0.061 0.0596
Brugia malayi jmjC domain containing protein 0.0115 0.0886 0.4221
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0314 0.1251
Schistosoma mansoni rab6-interacting 0.0202 0.1654 0.1642
Onchocerca volvulus Peroxidase homolog 0.0053 0.033 0.1321
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.157
Echinococcus granulosus Vam6:Vps39 protein 0.0052 0.0323 0.0323
Schistosoma mansoni hypothetical protein 0.0202 0.1654 0.1642
Loa Loa (eye worm) hypothetical protein 0.0065 0.0444 0.1666
Mycobacterium tuberculosis Putative conserved ATPase 0.0086 0.0624 0.2154
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.007 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0127 0.0471
Loa Loa (eye worm) hypothetical protein 0.0057 0.0372 0.1393
Trypanosoma cruzi Valosin-containing protein, putative 0.0136 0.1069 0.4927
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0043 0.0028
Brugia malayi follicle stimulating hormone receptor 0.0249 0.2072 0.9881
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0136 0.1069 0.3429
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0053 0.0194
Schistosoma mansoni protein kinase 0.0177 0.1431 0.1418
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.007 0.0191
Plasmodium falciparum phd finger protein, putative 0.0035 0.0176 0.0697
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0107
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0065 0.0276
Trichomonas vaginalis chromobox protein, putative 0.0084 0.061 0.2001
Brugia malayi hypothetical protein 0.0052 0.0323 0.1535
Onchocerca volvulus Dual oxidase homolog 0.0053 0.033 0.1321
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0248 0.0248
Brugia malayi jmjC domain containing protein 0.0047 0.0277 0.1315
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0657
Loa Loa (eye worm) hypothetical protein 0.0041 0.0229 0.0855
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0166 0.1332 0.1332
Echinococcus multilocularis lipoxygenase domain containing protein 0.0202 0.1654 0.1654
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0311 0.0297
Echinococcus granulosus lipoxygenase domain containing protein 0.0202 0.1654 0.1654
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.007 0.03
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0166 0.1332 0.5004
Brugia malayi Doublecortin family protein 0.0202 0.1654 0.7886
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0337 0.0323
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0298 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1332 0.1319
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.007 0.007
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.6178 0.6178
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0112
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0033 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0107
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0136 0.1069 0.6316
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.016 0.0491
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0053 0.0337 0.0337
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0052 0.0323 0.0323
Echinococcus multilocularis neural cadherin 0.0017 0.0015 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0172 0.0172
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.007 0.0203
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.2072 0.7788
Trypanosoma brucei ISWI complex protein 0.0018 0.0028 0.01
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0046 0.0046
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0126 0.0466
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0187 0.1521 0.5716
Echinococcus multilocularis chromobox protein 1 0.0084 0.061 0.061
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.157
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0126 0.0466
Schistosoma mansoni protein kinase 0.0125 0.0972 0.0958
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0248 0.0248
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0175 0.1417 0.1417
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0886 0.0886
Mycobacterium tuberculosis Conserved protein 0.003 0.0126 0.0235
Loa Loa (eye worm) Notch2 0.0017 0.0015 0.005
Schistosoma mansoni cpg binding protein 0.0034 0.0162 0.0148
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1392 0.5112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0107
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0015 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0065 0.0178
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0033 0.0033
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0015 0.0015
Brugia malayi Carboxylesterase family protein 0.0065 0.0444 0.2114
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0126 0.0378
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.007 0.0191
Schistosoma mansoni DNA polymerase eta 0.0023 0.007 0.0056
Echinococcus granulosus dna polymerase eta 0.0023 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Schistosoma mansoni hypothetical protein 0.0052 0.0323 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0372 0.0358
Loa Loa (eye worm) hypothetical protein 0.006 0.0399 0.1495
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0021 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Onchocerca volvulus 0.0202 0.1654 0.6859
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0444 0.0444
Brugia malayi EGF-like domain containing protein 0.0017 0.0015 0.0063
Schistosoma mansoni zinc finger protein 0.0018 0.0028 0.0013
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0444 0.0444
Echinococcus granulosus microtubule associated protein 2 0.0712 0.6178 0.6178
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1237
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0065 0.0178
Echinococcus multilocularis chromobox protein 1 0.0084 0.061 0.061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0372 0.0372
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.005
Loa Loa (eye worm) doublecortin family protein 0.0202 0.1654 0.6216
Echinococcus multilocularis sphingosine kinase 1 0.0316 0.2661 0.2661
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0886 0.0886
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1392 0.5112
Echinococcus multilocularis zinc finger protein 0.0025 0.0088 0.0088
Brugia malayi CHD4 protein 0.0018 0.0021 0.0096
Trypanosoma brucei Valosin-containing protein 0.0136 0.1069 0.4977
Loa Loa (eye worm) VCP protein 0.0059 0.0389 0.1459
Giardia lamblia DINP protein human, muc B family 0.0023 0.007 0.0188
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2992 1
Echinococcus granulosus peroxidasin 0.0053 0.033 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.007 0.03
Leishmania major DNA polymerase eta, putative 0.0023 0.007 0.0203

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.2668 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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