Detailed information for compound 1519056

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.51 | Formula: C26H26N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.28 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cn(c(n1)c1ccncc1)CCC(=O)NCc1ccc(cc1)C
  • InChi: 1S/C26H26N4O2/c1-19-3-5-20(6-4-19)17-28-25(31)13-16-30-18-24(21-7-9-23(32-2)10-8-21)29-26(30)22-11-14-27-15-12-22/h3-12,14-15,18H,13,16-17H2,1-2H3,(H,28,31)
  • InChiKey: LMXFEOAOHLFRFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi follicle stimulating hormone receptor 0.0228 0.3341 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0096 0.0219
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0096 0.0666
Echinococcus granulosus fibropellin Ia 0.0008 0.0046 0.0046
Giardia lamblia AAA family ATPase 0.0051 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0083 0.0083
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0083 0.0189
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.005 0.015
Echinococcus granulosus delta-like protein 1 0.0008 0.0046 0.0046
Brugia malayi probable protein kinase 0.0167 0.2423 0.7252
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0096 0.0539
Brugia malayi DIX domain containing protein 0.0011 0.0083 0.0248
Brugia malayi Ceramide kinase 0.0012 0.0096 0.0287
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0046 0.0138
Schistosoma mansoni hypothetical protein 0.0049 0.0655 0.0655
Plasmodium vivax cell division cycle ATPase, putative 0.0031 0.0385 0.1833
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Mycobacterium tuberculosis Conserved protein 0.0298 0.4386 1
Schistosoma mansoni hypothetical protein 0.0398 0.5895 0.5895
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0096 0.0682
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0046 0.0046
Brugia malayi RasGEF domain containing protein 0.0008 0.0037 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.007 0.0208
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.007 0.007
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Toxoplasma gondii hypothetical protein 0.0011 0.0083 0.0573
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0096 0.0682
Schistosoma mansoni coup transcription factor 0.001 0.007 0.007
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0046 0.0046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.3341 0.7617
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0081 0.1135 0.1135
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0096 0.0096
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.005 0.0677 0.0677
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0046 0.0046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0026
Echinococcus multilocularis protein jagged 1 0.0008 0.0046 0.0046
Echinococcus granulosus ras GTP exchange factor 0.0008 0.0037 0.0037
Schistosoma mansoni thyroid hormone receptor 0.001 0.007 0.007
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus sphingosine kinase 1 0.0298 0.4386 0.4386
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus multilocularis RUN 0.0117 0.1672 0.1672
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Schistosoma mansoni protein kinase 0.005 0.0677 0.0677
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0156 0.2265 0.2265
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0306 0.0853
Schistosoma mansoni rab6-interacting 0.0117 0.1672 0.1672
Onchocerca volvulus 0.0008 0.0046 0.0029
Brugia malayi nuclear hormone receptor 0.001 0.007 0.0208
Brugia malayi RasGEF domain containing protein 0.0008 0.0037 0.011
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.007 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.007 0.007
Schistosoma mansoni ras GTP exchange factor 0.0008 0.0037 0.0037
Echinococcus granulosus FTZ F1 alpha 0.001 0.007 0.007
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0083 0.0083
Echinococcus granulosus protein jagged 2 0.0008 0.0046 0.0046
Echinococcus granulosus protein jagged 1 0.0008 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.007 0.0208
Schistosoma mansoni peroxidasin 0.0026 0.0306 0.0306
Brugia malayi valosin containing protein 0.005 0.0672 0.2011
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.007 0.007
Loa Loa (eye worm) notch protein 0.0008 0.0046 0.0105
Schistosoma mansoni sphingoid long chain base kinase 0.0298 0.4386 0.4386
Schistosoma mansoni rab6-interacting 0.0117 0.1672 0.1672
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0083 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.007 0.0208
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0306 0.0698
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni cpg binding protein 0.0028 0.0341 0.0341
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Echinococcus multilocularis microtubule associated protein 2 0.0672 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.007 0.007
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.007 0.0159
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Loa Loa (eye worm) hypothetical protein 0.0117 0.1672 0.3813
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Onchocerca volvulus 0.0117 0.1672 0.5183
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0083 0.0248
Echinococcus granulosus dnaJ subfamily B 0.0398 0.5895 0.5895
Schistosoma mansoni slit 0.0008 0.0046 0.0046
Brugia malayi Peroxidasin 0.0026 0.0306 0.0916
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.007 0.007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.007 0.0104
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.005 0.0677 0.0677
Echinococcus multilocularis fibropellin Ia 0.0008 0.0046 0.0046
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0052 0.0118
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.007 0.007
Echinococcus multilocularis lipoxygenase domain containing protein 0.0117 0.1672 0.1672
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0096 0.0287
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0096 0.0666
Trypanosoma cruzi Valosin-containing protein, putative 0.0081 0.1135 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0096 0.0666
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.007 0.007
Loa Loa (eye worm) Notch2 0.0008 0.0046 0.0105
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.007 0.0208
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0096 0.0219
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0037 0.0084
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0096 0.0539
Brugia malayi Temporarily assigned gene name protein 59 0.0049 0.0655 0.196
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0037 0.0037
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0096 0.0666
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0008 0.0037 0.0037
Onchocerca volvulus 0.0008 0.0046 0.0029
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0096 0.0539
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Brugia malayi N-terminal motif family protein 0.0008 0.0037 0.011
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.3192 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.005 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Schistosoma mansoni nuclear hormone receptor 0.001 0.007 0.007
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0081 0.1135 0.2524
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.2568 0.2568
Echinococcus granulosus protein kinase 0.0118 0.169 0.169
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.005 0.0677 0.0677
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Trichomonas vaginalis ras GTP exchange factor, putative 0.0008 0.0037 0.0167
Brugia malayi Blistered cuticle protein 3 0.0026 0.0306 0.0916
Onchocerca volvulus 0.0049 0.0655 0.1959
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.007 0.0159
Onchocerca volvulus Peroxidase homolog 0.0026 0.0306 0.0853
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Schistosoma mansoni lipoxygenase 0.0427 0.6325 0.6325
Echinococcus granulosus slit 2 protein 0.0008 0.0046 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Brugia malayi hypothetical protein 0.0117 0.1672 0.5006
Loa Loa (eye worm) hypothetical protein 0.0298 0.4386 1
Echinococcus granulosus protein jagged 1 0.0008 0.0046 0.0046
Echinococcus granulosus peroxidasin 0.0026 0.0306 0.0306
Onchocerca volvulus 0.0026 0.0306 0.0853
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0096 0.0096
Echinococcus granulosus ceramide kinase 0.0012 0.0096 0.0096
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Onchocerca volvulus 0.0008 0.0046 0.0029
Echinococcus multilocularis protein jagged 2 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.007 0.007
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0046 0.0046
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0046 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.007 0.007
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0008 0.0037 0.0167
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0046 0.0046
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0081 0.1135 0.659
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.007 0.0208
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Schistosoma mansoni vam6/vps39 related 0.0049 0.0655 0.0655
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0085 0.1201 0.1201
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0083 0.0083
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.005 0.0677 0.0677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.007 0.0159
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0096 0.0136
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0655 0.5631
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0117 0.1672 0.1672
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.2265 0.2265
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.007 0.0208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0084
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0096 0.0287
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0096 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.005 0.0672 0.1532
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Brugia malayi Cadherin domain containing protein 0.0008 0.0046 0.0138
Brugia malayi steroid hormone receptor 0.001 0.007 0.0208
Echinococcus multilocularis expressed conserved protein 0.0006 0.0015 0.0015
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0046 0.0029
Schistosoma mansoni lipoxygenase 0.0637 0.9476 0.9476
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0081 0.1135 0.6756
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0083 0.0083
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0096 0.0219
Echinococcus granulosus lipoxygenase domain containing protein 0.0117 0.1672 0.1672
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0717 0.5918
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.007 0.0208
Echinococcus multilocularis Polycystic kidney disease protein 0.0117 0.1672 0.1672
Echinococcus granulosus protein jagged 2 0.0008 0.0046 0.0046
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0096 0.0187
Echinococcus granulosus lipoxygenase domain containing protein 0.0117 0.1672 0.1672
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0081 0.1135 1
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0083 0.0083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.007 0.007
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0083 0.0083
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0015 0.0015
Schistosoma mansoni dep domain containing protein 0.0011 0.0083 0.0083
Onchocerca volvulus Peroxidase homolog 0.0026 0.0306 0.0853
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0035 0.0451 0.1349
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0096 0.0488
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.007 0.0208
Echinococcus multilocularis son of sevenless 1 0.0008 0.0037 0.0037
Onchocerca volvulus 0.001 0.007 0.0104
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0085 0.1201 0.3688
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.2265 0.5165
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0008 0.0037 0.0037
Loa Loa (eye worm) vesicle-fusing ATPase 0.005 0.0672 0.1532
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0046 0.0046
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.005 0.0677 0.1544
Brugia malayi hypothetical protein 0.0026 0.0306 0.0916
Schistosoma mansoni thyroid hormone receptor 0.001 0.007 0.007
Toxoplasma gondii EGF family domain-containing protein 0.0008 0.0046 0.0262
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0046 0.0138
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0049 0.0655 0.0655
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0341 0.0778
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0096 0.0096
Echinococcus multilocularis 0.0118 0.169 0.169
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.002 0.0224 0.1751
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0096 0.0136
Onchocerca volvulus 0.0117 0.1672 0.5183
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0096 0.0096
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0655 0.5631
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.005 0.0677 0.0677
Mycobacterium tuberculosis Putative conserved ATPase 0.0051 0.0687 0.1378
Loa Loa (eye worm) hypothetical protein 0.0049 0.0655 0.1493
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0118 0.169 0.3853
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0052
Mycobacterium ulcerans hypothetical protein 0.0298 0.4386 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0096 0.0136
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0083 0.0083
Schistosoma mansoni protein kinase 0.0167 0.2423 0.2423
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.007 0.007
Onchocerca volvulus 0.0012 0.0096 0.0187
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0083 0.0248
Schistosoma mansoni rap gtpase-activating protein 0.0049 0.0655 0.0655
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0037 0.0084
Schistosoma mansoni cpg binding protein 0.003 0.0365 0.0365
Schistosoma mansoni dishevelled 0.0011 0.0083 0.0083
Trichomonas vaginalis bmru protein, putative 0.0012 0.0096 0.0666
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.007 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0677 0.0677
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0046 0.0138
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.2265 0.5165
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0096 0.0539
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0156 0.2265 0.6781
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0096 0.0219
Brugia malayi N-terminal motif family protein 0.0008 0.0037 0.011
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0096 0.0722
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0037 0.0084
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Onchocerca volvulus Putative cubilin 0.0008 0.0046 0.0029
Echinococcus multilocularis ceramide kinase 0.0012 0.0096 0.0096
Entamoeba histolytica hypothetical protein, conserved 0.0298 0.4386 1
Onchocerca volvulus 0.0008 0.0046 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.001 0.007 0.0208
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.007 0.007
Toxoplasma gondii cell division protein CDC48CY 0.0085 0.1201 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Leishmania major hypothetical protein, conserved 0.0012 0.0096 0.0722
Brugia malayi hypothetical protein 0.0012 0.0096 0.0287
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0049 0.0655 0.0655
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0085 0.1201 0.1201
Onchocerca volvulus 0.0008 0.0046 0.0029
Brugia malayi diacylglycerol kinase 0.0012 0.0096 0.0287
Echinococcus granulosus notch 0.0008 0.0046 0.0046
Brugia malayi Cadherin domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni sphingosine kinase A B 0.0298 0.4386 0.4386
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0085 0.1201 0.1201
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0096 0.0666
Loa Loa (eye worm) hypothetical protein 0.0049 0.0655 0.1493
Brugia malayi hypothetical protein 0.0011 0.0083 0.0248
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.007 0.0208
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0083 0.0248
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0049 0.0655 0.0655
Onchocerca volvulus 0.0011 0.0083 0.0146
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0096 0.0136
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0096 0.0722
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0026 0.0026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0046 0.0046
Brugia malayi map kinase activated protein kinase protein 2 0.0176 0.2568 0.7686
Onchocerca volvulus 0.0026 0.0306 0.0853
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0156 0.2265 0.7063
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0096 0.0666
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0096 0.0488
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0165 0.24 0.24
Echinococcus multilocularis FTZ F1 alpha 0.001 0.007 0.007
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0015 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.001 0.007 0.0159
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0096 0.0096
Echinococcus multilocularis ras GTP exchange factor 0.0008 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.007 0.0208
Echinococcus granulosus cGMP dependent protein kinase 0.0006 0.0015 0.0015
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0008 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0189
Onchocerca volvulus 0.0026 0.0306 0.0853
Echinococcus multilocularis peroxidasin 0.0026 0.0306 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0015 0.0015
Brugia malayi ecdysteroid receptor 0.001 0.007 0.0208
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0083 0.0083
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0096 0.0219
Brugia malayi Muscle positioning protein 4 0.0008 0.0046 0.0138
Brugia malayi RasGEF domain containing protein 0.0008 0.0037 0.011
Echinococcus multilocularis slit 2 protein 0.0008 0.0046 0.0046
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0049 0.0655 0.0655
Brugia malayi vesicle-fusing ATPase 0.005 0.0672 0.2011
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0085 0.1201 1
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Brugia malayi hypothetical protein 0.0117 0.1672 0.5006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0096 0.0539
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0015 0.0015
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0096 0.0096
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0096 0.0539
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0176 0.2568 0.2568
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.007 0.007
Schistosoma mansoni protein kinase 0.0118 0.169 0.169
Loa Loa (eye worm) ceramide kinase 0.0012 0.0096 0.0219
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.007 0.0208
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.007 0.007
Brugia malayi Doublecortin family protein 0.0117 0.1672 0.5006
Mycobacterium ulcerans ATPase 0.0051 0.0687 0.1378
Brugia malayi Protein kinase domain containing protein 0.005 0.0677 0.2028
Loa Loa (eye worm) hypothetical protein 0.0165 0.24 0.5473
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0052
Brugia malayi nuclear receptor NHR-88 0.001 0.007 0.0208
Brugia malayi hypothetical protein 0.0049 0.0655 0.196
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Echinococcus granulosus neural cadherin 0.0008 0.0046 0.0046
Trypanosoma brucei Valosin-containing protein 0.0081 0.1135 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0096 0.0682
Loa Loa (eye worm) VCP protein 0.0035 0.0451 0.1028
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0035 0.0451 0.0451
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.007 0.007
Schistosoma mansoni loxhd1 0.0117 0.1672 0.1672
Onchocerca volvulus Bile acid receptor homolog 0.001 0.007 0.0104
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0096 0.0666
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0812 0.0812
Echinococcus multilocularis lipoxygenase domain containing protein 0.0117 0.1672 0.1672
Brugia malayi CXXC zinc finger family protein 0.0028 0.0341 0.1022
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.002 0.0224 0.1751
Entamoeba histolytica cdc48-like protein, putative 0.0081 0.1135 0.2524
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0306 0.0853
Echinococcus multilocularis neural cadherin 0.0008 0.0046 0.0046
Echinococcus granulosus Protein son of sevenless 0.0008 0.0037 0.0037
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0637 0.9476 0.9476
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0306 0.0853
Echinococcus multilocularis cpg binding protein 0.003 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Plasmodium falciparum LCCL domain-containing protein 0.0117 0.1672 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0008 0.0037 0.0037
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0176 0.2568 0.2568
Schistosoma mansoni dishevelled 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0049 0.0655 0.1493
Brugia malayi hypothetical protein 0.0011 0.0083 0.0248
Brugia malayi Egg laying defective protein 4 0.0006 0.0015 0.0045
Echinococcus multilocularis protein jagged 1 0.0008 0.0046 0.0046
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0037 0.0037
Echinococcus granulosus son of sevenless 1 0.0008 0.0037 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.007 0.007
Echinococcus multilocularis Protein son of sevenless 0.0008 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0637 0.9476 0.9476
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0189
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Brugia malayi Delta serrate ligand family protein 0.0008 0.0046 0.0138
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0026 0.0026
Schistosoma mansoni cpg binding protein 0.003 0.0365 0.0365
Echinococcus granulosus Polycystic kidney disease protein 0.0117 0.1672 0.1672
Schistosoma mansoni cell polarity protein 0.0008 0.0046 0.0046
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.5895 0.5895
Brugia malayi Protein kinase domain containing protein 0.0156 0.2265 0.6781
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.007 0.0208
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0306 0.0853
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0083 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0096 0.0539
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0046 0.0046
Loa Loa (eye worm) doublecortin family protein 0.0117 0.1672 0.3813
Loa Loa (eye worm) AGC/PKG protein kinase 0.0006 0.0015 0.0034
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.007 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.007 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Onchocerca volvulus Slit protein homolog 0.0008 0.0046 0.0029
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0031 0.0031
Trichomonas vaginalis bmru protein, putative 0.0012 0.0096 0.0666
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0035 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0189
Echinococcus granulosus RUN 0.0117 0.1672 0.1672
Schistosoma mansoni peroxidasin 0.0026 0.0306 0.0306
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.007 0.0159
Loa Loa (eye worm) hypothetical protein 0.0117 0.1672 0.3813
Schistosoma mansoni polycystin 1-related 0.0117 0.1672 0.1672
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0176 0.2568 0.5854
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Leishmania major diacylglycerol kinase, putative 0.0012 0.0096 0.0722
Echinococcus multilocularis notch 0.0008 0.0046 0.0046
Plasmodium vivax multidomain scavenger receptor, putative 0.0117 0.1672 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0156 0.2265 0.2265
Echinococcus granulosus cpg binding protein 0.003 0.0365 0.0365
Echinococcus multilocularis sphingosine kinase 1 0.0298 0.4386 0.4386
Onchocerca volvulus 0.0028 0.0341 0.0966
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Trichomonas vaginalis ras GTP exchange factor, putative 0.0008 0.0037 0.0167
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus Vam6:Vps39 protein 0.0049 0.0655 0.0655
Brugia malayi notch-like transmembrane receptor 0.0008 0.0046 0.0138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.007 0.007
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0008 0.0037 0.0167
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0008 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.007 0.007
Schistosoma mansoni microtubule-associated protein tau 0.0672 1 1
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0096 0.0539
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0083 0.0146
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0083 0.0189
Schistosoma mansoni septate junction protein 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0218 0.3192 0.7278
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.007 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.007 0.0159
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0096 0.0666
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.007 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.007 0.0159
Leishmania major hypothetical protein, conserved 0.0012 0.0096 0.0722
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Schistosoma mansoni hypothetical protein 0.0012 0.0096 0.0096
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0655 0.5382
Toxoplasma gondii cell division protein CDC48AP 0.0051 0.0687 0.567
Brugia malayi diacylglycerol kinase 0.0012 0.0096 0.0287
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0051 0.0687 0.567
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0096 0.0096
Brugia malayi N-terminal motif family protein 0.0218 0.3192 0.9555

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1651 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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