Detailed information for compound 1519368

Basic information

Technical information
  • TDR Targets ID: 1519368
  • Name: N-butyl-2-(2',5'-dioxospiro[2,3-dihydro-1H-na phthalene-4,4'-imidazolidine]-1'-yl)acetamide
  • MW: 329.394 | Formula: C18H23N3O3
  • H donors: 2 H acceptors: 3 LogP: 2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)CN1C(=O)NC2(C1=O)CCCc1c2cccc1
  • InChi: 1S/C18H23N3O3/c1-2-3-11-19-15(22)12-21-16(23)18(20-17(21)24)10-6-8-13-7-4-5-9-14(13)18/h4-5,7,9H,2-3,6,8,10-12H2,1H3,(H,19,22)(H,20,24)
  • InChiKey: PSNDCKFGFBMPCZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-2-(2,5-dioxospiro[imidazolidine-4,1'-tetralin]-1-yl)acetamide
  • N-butyl-2-(2,5-dioxo-1-spiro[imidazolidine-4,1'-tetralin]yl)acetamide
  • N-butyl-2-(2,5-diketospiro[imidazolidine-4,1'-tetralin]-1-yl)acetamide
  • N-butyl-2-(2',5'-dioxospiro[2,3-dihydro-1H-naphthalene-4,4'-imidazolidine]-1'-yl)ethanamide
  • MLS000565096
  • SMR000152264

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0139 0.0706
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0139 0.0873
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0161 0.3082
Loa Loa (eye worm) hypothetical protein 0.0087 0.0173 0.0878
Echinococcus granulosus epidermal growth factor receptor 0.0418 0.093 0.587
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0026 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0446 1
Onchocerca volvulus 0.0155 0.0327 0.1459
Brugia malayi hypothetical protein 0.0038 0.006 0.0307
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0223 0.0201
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0051 0.0319
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0139 0.0706
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0105 0.0534
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0026 0.0162
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0105 0.2085
Schistosoma mansoni adenoreceptor 0.0023 0.0026 0.0162
Echinococcus granulosus epidermal growth factor receptor 0.0258 0.0563 0.3553
Onchocerca volvulus Tyrosine kinase homolog 0.0173 0.037 0.1651
Loa Loa (eye worm) hypothetical protein 0.0148 0.0311 0.1582
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0161 0.3208
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0026 0.0132
Brugia malayi MH2 domain containing protein 0.0122 0.0252 0.1285
Trypanosoma brucei ISWI complex protein 0.0031 0.0043 0.0202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0027 0.0037
Trypanosoma cruzi WLM domain containing protein, putative 0.0082 0.0161 0.3208
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0223 0.0201
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0258 0.0563 0.3553
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0082 0.0161 0.3208
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0076 0.0223
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0232 0.0503 1
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0035 0.0178
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0045 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0105 0.1861
Schistosoma mansoni coup transcription factor 0.0073 0.0139 0.0873
Brugia malayi G protein-coupled receptor 0.0023 0.0026 0.0132
Schistosoma mansoni hypothetical protein 0.0232 0.0503 0.3175
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi nuclear receptor NHR-88 0.0034 0.0051 0.0259
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0082 0.0161 0.3205
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0167 0.0633
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0259 0.0356
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0026 0.0162
Onchocerca volvulus 0.0109 0.0223 0.0997
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0105 0.0144
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0026 0.0162
Onchocerca volvulus 0.0073 0.0139 0.0619
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0139 0.0619
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0223 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0521 0.3289
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0023 0.0031
Echinococcus granulosus roundabout 2 0.0022 0.0022 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3193 0.7285 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0105 0.171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0026 0.0035
Schistosoma mansoni hypothetical protein 0.0232 0.0503 0.3175
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0311 0.1582
Trypanosoma cruzi ISWI complex protein 0.0031 0.0043 0.0381
Echinococcus granulosus ring and YY1 binding protein 0.0082 0.0161 0.1016
Loa Loa (eye worm) hypothetical protein 0.0155 0.0327 0.1664
Onchocerca volvulus 0.0232 0.0503 0.2247
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0026 0.0035
Onchocerca volvulus 0.0034 0.0051 0.0227
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0146 0.092
Schistosoma mansoni fusion 0.0082 0.0161 0.1016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0107 0.0675
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0139 0.0873
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0139 0.0873
Echinococcus multilocularis SWI:SNF matrix associated 0.0232 0.0503 0.069
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0139 0.0706
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0105 0.0083
Brugia malayi Bromodomain containing protein 0.0152 0.0322 0.1637
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Mycobacterium tuberculosis Conserved protein 0.0109 0.0223 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0139 0.0706
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0045 0.0045
Mycobacterium ulcerans beta-lactamase 0.0109 0.0223 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0061
Loa Loa (eye worm) TK/EGFR protein kinase 0.0418 0.093 0.4735
Loa Loa (eye worm) hypothetical protein 0.0082 0.016 0.0815
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0138 0.0189
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0026 0.0116
Loa Loa (eye worm) beta-lactamase 0.0109 0.0223 0.1136
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0051 0.0259
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.008 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0223 0.0887
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0045 0.0421
Echinococcus granulosus dnaJ subfamily B 0.0397 0.0881 0.5557
Toxoplasma gondii exonuclease III APE 0.0058 0.0105 0.0105
Mycobacterium ulcerans hypothetical protein 0.0109 0.0223 0.0201
Brugia malayi Protein kinase domain containing protein 0.0089 0.0176 0.0894
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis epidermal growth factor receptor 0.0258 0.0563 0.0773
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0338 0.2131
Schistosoma mansoni glutaminase 0.0271 0.0593 0.3738
Echinococcus granulosus SWI:SNF matrix associated 0.0232 0.0503 0.3175
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0026 0.0162
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0026 0.0162
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0026 0.0035
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0139 0.019
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0051 0.0259
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni biogenic amine receptor 0.0023 0.0026 0.0162
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Onchocerca volvulus 0.0023 0.0026 0.0116
Giardia lamblia Kinase, PLK 0.0092 0.0182 1
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0139 0.019
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0139 0.0706
Brugia malayi Latrophilin receptor protein 2 0.0047 0.008 0.0405
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0027 0.0168
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0139 0.019
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0107 0.1919
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.087 0.1964 1
Brugia malayi ecdysone receptor 0.0034 0.0051 0.0259
Schistosoma mansoni histamine h1 receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0223 0.0201
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0026 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0026 0.0162
Schistosoma mansoni hypothetical protein 0.0031 0.0043 0.0269
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.008 0.0502
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0051 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0248 0.156
Echinococcus granulosus fmrfamide receptor 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0051 0.0259
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis zinc finger protein Ran binding 0.0082 0.0161 0.0221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0521 0.3289
Brugia malayi G-protein coupled receptor 0.0023 0.0026 0.0132
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0051 0.0259
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis zinc finger protein 0.0041 0.0066 0.009
Brugia malayi nuclear hormone receptor 0.0073 0.0139 0.0706
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0105 0.5
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0026 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0232 0.0503 1
Schistosoma mansoni hypothetical protein 0.0704 0.1584 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0223 0.1136
Echinococcus granulosus histone lysine methyltransferase setb 0.016 0.0338 0.2131
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0051 0.0319
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0026 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0521 0.3289
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0013 0.0003 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi AKH receptor 0.0023 0.0026 0.0132
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0026 0.0162
Mycobacterium tuberculosis Conserved protein 0.0024 0.0027 0.0004
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0265 0.058 0.0796
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0537 0.2733
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.008 0.05
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0051 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0139 0.0706
Toxoplasma gondii ran binding protein 0.0082 0.0161 0.0161
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0026 0.0162
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0139 0.0706
Onchocerca volvulus 0.016 0.034 0.1516
Onchocerca volvulus 0.0023 0.0026 0.0116
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0232 0.0503 1
Leishmania major hypothetical protein, conserved 0.0031 0.0043 0.0381
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0051 0.0069
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0026 0.0132
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0699 0.1574 0.1555
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0061
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0082 0.0161 0.3082
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0051 0.0259
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0051 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0139 0.0706
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0045 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0105 0.0352
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0107 0.0675
Brugia malayi steroid hormone receptor 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0026 0.0035
Schistosoma mansoni hypothetical protein 0.0082 0.0161 0.1016
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0182 0.025
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0026 0.0132
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0045 0.0045
Brugia malayi neuropeptide F receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) glutaminase 0.0271 0.0593 0.3016
Brugia malayi hypothetical protein 0.0038 0.006 0.0307
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0311 0.1582
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0026 0.0035
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0026 0.0162
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.062 0.0851
Loa Loa (eye worm) hypothetical protein 0.0104 0.0211 0.1073
Schistosoma mansoni cell adhesion molecule 0.0014 0.0005 0.0031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0223 0.0201
Brugia malayi nuclear receptor NHR-88 0.0073 0.0139 0.0706
Echinococcus granulosus zinc finger protein Ran binding 0.0082 0.0161 0.1016
Schistosoma mansoni nuclear receptor 0.0034 0.0051 0.0319
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0045 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0139 0.0619
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0013 0.0003 0.0003
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0014 0.0005 0.0031
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0167 0.0229
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0026 0.0035
Echinococcus granulosus twitchin 0.0018 0.0015 0.0091
Brugia malayi conserved hypotetical protein 0.0034 0.0051 0.0259
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0107 0.0085
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0035 0.0688
Brugia malayi Furin-like cysteine rich region family protein 0.0418 0.093 0.4735
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0026 0.0035
Schistosoma mansoni tyrosine kinase 0.0265 0.058 0.3661
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0026 0.0162
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0051 0.0319
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0026 0.0162
Onchocerca volvulus 0.0028 0.0036 0.0162
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.4379 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0167 0.085
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0139 0.0873
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0142 0.0298 0.1518
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0105 0.0352
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.0405
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0146 0.092
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.0182
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0026 0.0162
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0161 0.3208
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0003 0.0003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Brugia malayi sulfakinin receptor protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0051 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Brugia malayi CHE-14 protein 0.0085 0.0167 0.085
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0027 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0139 0.0706
Onchocerca volvulus 0.0023 0.0026 0.0116
Brugia malayi neuropeptide F receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus granulosus GPCR family 2 0.0047 0.008 0.05
Mycobacterium ulcerans lipase LipD 0.0109 0.0223 0.0201
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0026 0.0035
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0182 0.1148
Brugia malayi nuclear hormone receptor 0.0034 0.0051 0.0259
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0026 0.0132
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Echinococcus granulosus zinc finger protein 0.0041 0.0066 0.0416
Onchocerca volvulus 0.0082 0.0161 0.072
Brugia malayi Pre-SET motif family protein 0.087 0.1964 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0026 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0259 0.1635
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0051 0.0227
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0161 0.3082
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0026 0.0162
Schistosoma mansoni bromodomain containing protein 0.0129 0.0268 0.1687
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0223 0.0201
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.062 0.3915
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0076 0.0223
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0061
Onchocerca volvulus 0.0023 0.0026 0.0116
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0026 0.0035
Schistosoma mansoni tyrosine kinase 0.0017 0.0011 0.0065
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0026 0.0132
Brugia malayi nuclear receptor RXR 0.0034 0.0051 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0051 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0107 0.0085
Echinococcus granulosus sex peptide receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.0251 0.0344
Echinococcus multilocularis SWI:SNF matrix associated 0.0232 0.0503 0.069
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0035 0.0035
Brugia malayi ecdysteroid receptor 0.0073 0.0139 0.0706
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.006 0.0378
Trichomonas vaginalis set domain proteins, putative 0.099 0.2239 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0027 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0223 0.4686
Brugia malayi hypothetical protein 0.0155 0.0327 0.1664
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0026 0.0162
Echinococcus granulosus insulin receptor 0.0265 0.058 0.3661
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0105 0.0534
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.006 0.0378
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0026 0.0132
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0082 0.0161 0.3208
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0139 0.0619
Schistosoma mansoni tyrosine kinase 0.0252 0.055 0.3469
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0537 0.2733
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Leishmania major hypothetical protein, conserved 0.0207 0.0446 1
Brugia malayi brahma associated protein 60 kDa 0.0232 0.0503 0.2562
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0139 0.0706
Schistosoma mansoni biogenic amine receptor 0.0023 0.0026 0.0162
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0026 0.0162
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0026 0.0132
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0026 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0223 0.0887
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0026 0.0132
Schistosoma mansoni zinc finger protein 0.0034 0.0051 0.0319
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0232 0.0503 0.2562
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0023 0.0031
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni zinc finger protein 0.0041 0.0066 0.0416
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0026 0.0035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0107 0.0147
Loa Loa (eye worm) TK protein kinase 0.0013 0.0003 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0161 0.3208
Echinococcus granulosus neuroglian 0.0018 0.0014 0.0087
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0139 0.0873
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0051 0.0259
Onchocerca volvulus 0.0023 0.0026 0.0116
Loa Loa (eye worm) DR-78 0.0034 0.0051 0.0259
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0146 0.02
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0035
Echinococcus multilocularis serotonin receptor 0.0023 0.0026 0.0035
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0082 0.0161 0.072
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0045 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0279
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0265 0.058 0.3661
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0026 0.0162
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0026 0.0162
Echinococcus multilocularis geminin 0.0704 0.1584 0.2175
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi GnHR receptor homolog 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0154 0.0325 0.0303
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0026 0.0162
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0082 0.0161 0.3208
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0154 0.0325 0.0303
Brugia malayi hypothetical protein 0.0034 0.0051 0.0259
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0107 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0139 0.0706
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.0688
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0026 0.0162
Schistosoma mansoni RNA binding protein 0.0082 0.0161 0.1016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0118 0.0744
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Onchocerca volvulus 0.0109 0.0223 0.0997
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0026 0.0162
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0026 0.0035
Trypanosoma brucei polo-like protein kinase 0.0092 0.0182 0.359
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0051 0.0259
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0026 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0138 0.0869
Onchocerca volvulus 0.0023 0.0026 0.0116
Echinococcus multilocularis expressed conserved protein 0.0186 0.0398 0.0546
Schistosoma mansoni ap endonuclease 0.0058 0.0105 0.066
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0182 0.0928
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0051 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0051 0.0319
Schistosoma mansoni zinc finger protein 0.0031 0.0043 0.0269
Schistosoma mansoni ap endonuclease 0.0058 0.0105 0.066
Mycobacterium ulcerans hypothetical protein 0.0024 0.0027 0.0004
Brugia malayi glutaminase DH11.1 0.0271 0.0593 0.3016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni tyrosine kinase 0.0258 0.0563 0.3553
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0125 0.0259 0.1635
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0154 0.0325 0.0303
Onchocerca volvulus 0.0082 0.0161 0.072
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0051 0.0069
Onchocerca volvulus 0.0082 0.0161 0.072
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0051 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0139 0.0706
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0026 0.0035
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0154 0.0325 0.1347
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Echinococcus granulosus expressed conserved protein 0.0186 0.0398 0.2513
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0223 0.1407
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0105 0.066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni tyrosine kinase 0.0252 0.055 0.3469
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0167 0.1052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.016 0.0338 0.0463
Trypanosoma cruzi ISWI complex protein 0.0031 0.0043 0.0381
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0232 0.0503 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.0521 0.2654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0107 0.0085
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0026 0.0035
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0026 0.0162
Echinococcus multilocularis somatostatin receptor 0.0023 0.0026 0.0035
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0026 0.0116
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0023 0.0449
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.0386 0.1963
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.008 0.0109
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni cpg binding protein 0.0028 0.0036 0.0227
Schistosoma mansoni cpg binding protein 0.0033 0.0049 0.0305
Echinococcus multilocularis protein dispatched 1 0.0097 0.0195 0.0267
Brugia malayi larval opioid receptor 0.0023 0.0026 0.0132
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0139 0.019
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Schistosoma mansoni zinc finger protein 0.0082 0.0161 0.1016
Brugia malayi Dopamine receptor protein 1 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0167 0.085
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0338 0.2131
Onchocerca volvulus 0.0023 0.0026 0.0116
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0023 0.014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0139 0.0873
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0139 0.0706
Schistosoma mansoni hypothetical protein 0.0232 0.0503 0.3175
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0105 0.2085
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.0182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Schistosoma mansoni tyrosine kinase 0.0258 0.0563 0.3553
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0068 0.0344
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.008 0.0502
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0026 0.0162
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0115 0.0115
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0026 0.0162
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.006 0.0082
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0051 0.0319
Schistosoma mansoni nephrin 0.0018 0.0014 0.0087
Schistosoma mansoni cpg binding protein 0.0033 0.0049 0.0305
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Brugia malayi Dopamine receptor protein 2 0.0023 0.0026 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.008 0.0405
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0026 0.0035
Echinococcus granulosus allatostatin A receptor 0.0023 0.0026 0.0162
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0182 0.0814
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0223 0.1136
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0026 0.0132
Onchocerca volvulus 0.099 0.2239 1
Brugia malayi SWIB/MDM2 domain containing protein 0.0232 0.0503 0.2562
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0139 0.019
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0426 0.0584
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0026 0.0035
Brugia malayi Cytochrome P450 family protein 0.0027 0.0035 0.0178
Echinococcus granulosus neuropeptide receptor 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0139 0.0706
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0051 0.0259
Echinococcus multilocularis sex peptide receptor 0.0023 0.0026 0.0035
Echinococcus granulosus Aminotransferase class III 0.0022 0.0023 0.014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.008 0.05
Brugia malayi putative neuropeptide receptor 0.0023 0.0026 0.0132
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0139 0.0873
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0139 0.019
Onchocerca volvulus 0.0023 0.0026 0.0116
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0027 0.0004
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0003 0.0014
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Brugia malayi Dopamine receptor 0.0023 0.0026 0.0132
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0223 0.4435
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0051 0.0259
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0003 0.0015
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.006 0.0307
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0051 0.0319
Mycobacterium ulcerans hypothetical protein 0.0154 0.0325 0.0303
Echinococcus multilocularis protein patched 0.0085 0.0167 0.0229
Onchocerca volvulus 0.0023 0.0026 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0113
Brugia malayi PHD-finger family protein 0.0052 0.0091 0.0463
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.016 0.0338 0.172
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0026 0.0162
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0026 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0503 0.2153
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0182 0.3707
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0026 0.0132
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0182 0.3707
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0101 0.0204 0.1037
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0232 0.0503 0.069
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0051 0.0227
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.4379 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0223 0.0201
Brugia malayi YY1-associated factor 2 0.0082 0.0161 0.0821
Onchocerca volvulus 0.0023 0.0026 0.0116
Brugia malayi Serotonin receptor 0.0023 0.0026 0.0132
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.008 0.0405
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0045 0.0887
Echinococcus multilocularis SWI:SNF matrix associated 0.0232 0.0503 0.069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0162
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0223 0.1407
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0026 0.0035
Onchocerca volvulus 0.0109 0.0223 0.0997
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0082 0.0161 0.3082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0139 0.019
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0223 0.4588
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.006 0.0307
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0139 0.0873
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0139 0.0706
Schistosoma mansoni nuclear receptor 0.0034 0.0051 0.0319
Echinococcus granulosus Zinc finger RanBP2 type 0.0082 0.0161 0.1016
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Schistosoma mansoni hypothetical protein 0.0041 0.0068 0.0424
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Echinococcus multilocularis epidermal growth factor receptor 0.0418 0.093 0.1277
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0223 0.0306
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0045 0.0227
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0139 0.0873
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0426 0.2168
Brugia malayi Melatonin receptor type 1A 0.0023 0.0026 0.0132
Echinococcus granulosus hypothetical protein 0.0023 0.0026 0.0162
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0139 0.0873
Mycobacterium tuberculosis Conserved protein 0.0109 0.0223 0.0201
Echinococcus multilocularis cpg binding protein 0.0033 0.0049 0.0066
Echinococcus granulosus g protein coupled receptor 0.0023 0.0026 0.0162
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0105 0.0083
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.0881 0.1208
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0026 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0003 0.0014
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0082 0.0161 0.3208
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Echinococcus granulosus serotonin receptor 0.0023 0.0026 0.0162
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0223 0.0201
Brugia malayi nuclear receptor NHR-67 0.0034 0.0051 0.0259
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0139 0.0873
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0139 0.0873
Brugia malayi beta-lactamase 0.0109 0.0223 0.1136
Brugia malayi Pre-SET motif family protein 0.0125 0.0259 0.1321
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0223 0.0887
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0139 0.0706
Echinococcus multilocularis 0.0127 0.0264 0.0361
Brugia malayi isocitrate dehydrogenase 0.0031 0.0045 0.0227
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0026 0.0162
Echinococcus granulosus g protein coupled receptor 0.0023 0.0026 0.0162
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0023 0.014
Brugia malayi RE15519p 0.0023 0.0026 0.0132
Schistosoma mansoni hypothetical protein 0.0704 0.1584 1
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0139 0.0873
Brugia malayi Serotonin receptor 0.0023 0.0026 0.0132
Brugia malayi hypothetical protein 0.0018 0.0013 0.0064
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.006 0.0378
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0139 0.0706
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0433 0.2731
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.006 0.0307
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Schistosoma mansoni tyrosine kinase 0.0418 0.093 0.587
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0139 0.019
Schistosoma mansoni opsin-like receptor 0.0023 0.0026 0.0162
Schistosoma mansoni kinase 0.0047 0.0079 0.0497
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0011 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0223 0.0887
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0082 0.0161 0.1016
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0182 0.3707
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0426 0.2686
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0027
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0139 0.0873
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0026 0.0035
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0045 0.0243
Schistosoma mansoni hypothetical protein 0.0397 0.0881 0.5557
Mycobacterium leprae Probable lipase LipE 0.0109 0.0223 0.0201
Schistosoma mansoni hypothetical protein 0.0076 0.0146 0.092
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0026 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0023 0.0449
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0252 0.1285
Echinococcus granulosus orexin receptor type 2 0.0023 0.0026 0.0162
Brugia malayi hypothetical protein 0.0034 0.0051 0.0259
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0252 0.1285
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0167 0.1052
Brugia malayi CXXC zinc finger family protein 0.0028 0.0036 0.0185
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0139 0.0706
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0026 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0521 0.3289
Echinococcus multilocularis ring and YY1 binding protein 0.0082 0.0161 0.0221
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.0521 0.2654
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0036 0.0185
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0223 0.0201
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0259 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0521 0.0715
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Schistosoma mansoni brg-1 associated factor 0.0232 0.0503 0.3175
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0051 0.032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0045 0.0227
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0026 0.0035
Loa Loa (eye worm) glutaminase 2 0.0271 0.0593 0.3016
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0232 0.0503 0.0503
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0077 0.0149 0.076
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0223 0.4686
Loa Loa (eye worm) TK/ROR protein kinase 0.0013 0.0003 0.0014
Echinococcus multilocularis insulin receptor 0.0265 0.058 0.0796
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0023 0.0023
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0051 0.0069
Brugia malayi nuclear receptor RXR 0.0038 0.006 0.0307
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0026 0.0162
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0105 0.1861
Echinococcus multilocularis roundabout 2 0.0022 0.0022 0.003
Toxoplasma gondii pantoate-beta-alanine ligase 0.4379 1 1
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Bromodomain containing protein 0.0077 0.0149 0.0758
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0026 0.0035
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0023 0.0115
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0521 0.0715
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0082 0.0161 0.0161
Schistosoma mansoni TRABID protein (C64 family) 0.0082 0.0161 0.1016
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0521 0.3289
Brugia malayi hypothetical protein 0.0076 0.0146 0.0744
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0054 0.0274
Brugia malayi ORL1-like opioid receptor 0.0023 0.0026 0.0132
Schistosoma mansoni tyrosine kinase 0.0252 0.055 0.3469
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0232 0.0503 0.3175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0182 0.1148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0139 0.0706
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0223 0.1407
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.0251 0.1583
Leishmania major hypothetical protein, conserved 0.0109 0.0223 0.4686
Schistosoma mansoni myosin xvIII 0.0023 0.0026 0.0162
Toxoplasma gondii ABC1 family protein 0.0109 0.0223 0.0223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Chlamydia trachomatis DNA topoisomerase I 0.0232 0.0503 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0026 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0139 0.019
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0223 0.0887
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0426 1
Onchocerca volvulus 0.0125 0.0259 0.1158
Trypanosoma cruzi WLM domain containing protein, putative 0.0082 0.0161 0.3208
Plasmodium vivax SET domain protein, putative 0.0125 0.0259 0.5154
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0082 0.0161 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Loa Loa (eye worm) brahma associated protein 0.0232 0.0503 0.2562
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0182 0.0928
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0026 0.0162
Mycobacterium ulcerans glutaminase 0.0271 0.0593 0.0571
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Brugia malayi beta-lactamase family protein 0.0109 0.0223 0.1136
Echinococcus granulosus somatostatin receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0139 0.0873
Schistosoma mansoni biogenic amine receptor 0.0023 0.0026 0.0162
Onchocerca volvulus 0.0082 0.0161 0.072
Brugia malayi G-protein coupled receptor 0.0023 0.0026 0.0132
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0026 0.0035
Onchocerca volvulus 0.0023 0.0026 0.0116
Leishmania major hypothetical protein, conserved 0.0027 0.0035 0.0182
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0139 0.0873
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Echinococcus multilocularis neuroglian 0.0018 0.0014 0.0019
Loa Loa (eye worm) TK/KIN16 protein kinase 0.018 0.0386 0.1963
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0107 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0139 0.0706
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0105 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0311 0.1582
Onchocerca volvulus 0.0034 0.0051 0.0227
Echinococcus granulosus g protein coupled receptor 0.0023 0.0026 0.0162
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0027 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0026 0.0035
Brugia malayi tailless protein 0.0034 0.0051 0.0259
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0026 0.0132
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0026 0.0162
Mycobacterium tuberculosis Conserved protein 0.0109 0.0223 0.0201
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.0688
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0051 0.032
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0223 0.0201
Trichomonas vaginalis glutaminase, putative 0.0271 0.0593 0.2556
Echinococcus granulosus cpg binding protein 0.0033 0.0049 0.0305
Trichomonas vaginalis esterase, putative 0.0109 0.0223 0.0887
Brugia malayi beta-lactamase family protein 0.0109 0.0223 0.1136
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0051 0.032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0105 0.1861
Schistosoma mansoni hypothetical protein 0.0101 0.0204 0.1284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0176
Echinococcus granulosus neuropeptide receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) TK/INSR protein kinase 0.0265 0.058 0.2954
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0026 0.0035
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0045 0.0887
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0026 0.0132
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0232 0.0503 0.0503
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis GPCR, family 2 0.0047 0.008 0.0109
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0113
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0082 0.0161 0.3208
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni patched 1 0.0085 0.0167 0.1052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0139 0.0706
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0051 0.0319
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0182 0.2408
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0082 0.0161 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Echinococcus granulosus geminin 0.0704 0.1584 1
Schistosoma mansoni opsin-like receptor 0.0023 0.0026 0.0162
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0051 0.0319
Echinococcus multilocularis serotonin receptor 0.0023 0.0026 0.0035
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0045 0.0421
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0162
Mycobacterium tuberculosis Probable aminotransferase 0.0154 0.0325 0.0303
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0204 0.1037
Chlamydia trachomatis SWIB complex protein 0.0232 0.0503 1
Brugia malayi brahma associated protein 60 kDa 0.0232 0.0503 0.2562
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0139 0.0873
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0026 0.0162
Mycobacterium ulcerans hypothetical protein 0.0024 0.0027 0.0004
Schistosoma mansoni opsin-like receptor 0.0023 0.0026 0.0162
Brugia malayi hypothetical protein 0.0027 0.0035 0.0176
Loa Loa (eye worm) hypothetical protein 0.0198 0.0426 0.2168
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Brugia malayi Protein kinase domain containing protein 0.0265 0.058 0.2954
Schistosoma mansoni tyrosine kinase 0.0265 0.058 0.3661
Loa Loa (eye worm) hypothetical protein 0.0083 0.0162 0.0827
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.238721139 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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