Detailed information for compound 1536868

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.388 | Formula: C21H23BrN2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCC1CN(C(=O)C1CC(=O)Nc1ccc(cc1)OC)c1ccc(cc1)Br
  • InChi: 1S/C21H23BrN2O3S/c1-27-18-9-5-16(6-10-18)23-20(25)11-19-14(13-28-2)12-24(21(19)26)17-7-3-15(22)4-8-17/h3-10,14,19H,11-13H2,1-2H3,(H,23,25)
  • InChiKey: JEBTZDPCNLMQST-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0434 0.158
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0902 0.0902
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0196 0.0334
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0596 0.2166
Brugia malayi Calcitonin receptor-like protein seb-1 0.0415 0.3835 0.4677
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0224 0.2007 0.893
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0151 0.0147
Echinococcus granulosus calcium dependent protein kinase 0.0064 0.0463 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0561 0.5239 0.5595
Trichomonas vaginalis glutaminase, putative 0.0273 0.2474 0.2635
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0066 0.0482 0.9821
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0149
Schistosoma mansoni hypothetical protein 0.0221 0.1978 0.1978
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0033
Echinococcus granulosus peregrin 0.0029 0.0134 0.0134
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0221 0.1978 0.1978
Brugia malayi Cytochrome P450 family protein 0.0057 0.0399 0.0486
Echinococcus multilocularis dna polymerase eta 0.0019 0.0033 0.0033
Plasmodium falciparum calcium-dependent protein kinase 2 0.0068 0.0503 0.0552
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0196 0.1575
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0151 0.0147
Brugia malayi Latrophilin receptor protein 2 0.0131 0.1112 0.1356
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0196 0.0711
Loa Loa (eye worm) hypothetical protein 0.0415 0.3835 0.4268
Loa Loa (eye worm) hypothetical protein 0.0284 0.2575 0.2866
Brugia malayi Cytochrome P450 family protein 0.0025 0.0092 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0546 0.057
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0151 0.0549
Leishmania major DNA polymerase eta, putative 0.0019 0.0033 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.3386 0.3612
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0134 0.0149
Echinococcus granulosus snurportin 1 0.0951 0.8984 0.8984
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0134 0.0136
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.046 0.0561
Schistosoma mansoni tar DNA-binding protein 0.0063 0.046 0.046
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0179 0.0179
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.049 0.049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0131 0.1112 0.1112
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0797 0.2898
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0358 0.3287 0.5611
Leishmania major GTP-binding protein, putative 0.0066 0.0482 0.1752
Plasmodium falciparum calcium-dependent protein kinase 4 0.0068 0.0503 0.0552
Echinococcus granulosus solute carrier family 22 0.0031 0.0151 0.0151
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0151 0.0315
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0503 0.0503
Plasmodium falciparum importin beta, putative 0.0089 0.0708 0.0783
Schistosoma mansoni hypothetical protein 0.0023 0.0076 0.0076
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0511 0.186
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0596 0.2166
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.0255 0.0533
Loa Loa (eye worm) glutaminase 0.0273 0.2474 0.2754
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0625 0.0762
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0625 0.2272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.1065 0.1065
Plasmodium falciparum glutathione reductase 0.0034 0.0179 0.0187
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0037
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0179 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0151 0.0147
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.026 0.0944
Plasmodium vivax glutathione reductase, putative 0.0098 0.0797 0.0884
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0242 0.0242
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0196 0.0711
Plasmodium falciparum lysine--tRNA ligase 0.0049 0.0327 0.0353
Loa Loa (eye worm) sugar transporter 0.0031 0.0151 0.0168
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.2325 0.2325
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0596 0.2166
Trypanosoma brucei trypanothione reductase 0.0098 0.0797 0.2898
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0033 0.0041
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0151 0.0549
Brugia malayi RNA, U transporter 1 0.0253 0.2285 0.2786
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0151 0.0168
Loa Loa (eye worm) hypothetical protein 0.008 0.0625 0.0695
Echinococcus granulosus importin 5 0.0017 0.0014 0.0014
Brugia malayi beta-lactamase family protein 0.008 0.0625 0.0762
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Trichomonas vaginalis glucosylceramidase, putative 0.0388 0.3577 0.3816
Schistosoma mansoni tar DNA-binding protein 0.0063 0.046 0.046
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0033 0.0033
Plasmodium falciparum mitogen-activated protein kinase 2 0.0358 0.3287 0.3694
Schistosoma mansoni hypothetical protein 0.1057 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Echinococcus multilocularis snurportin 1 0.0951 0.8984 0.8984
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.3386 0.3612
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0179 0.0375
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0285 0.2588 0.2881
Schistosoma mansoni ran 0.0066 0.0482 0.0482
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0625 0.0625
Brugia malayi latrophilin 2 splice variant baaae 0.0284 0.2575 0.314
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.151 0.2577
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0179 0.0179
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0033 0.0122
Brugia malayi Sugar transporter family protein 0.0031 0.0151 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0092 0.0333
Loa Loa (eye worm) hypothetical protein 0.0126 0.1065 0.1186
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0093 0.0113
Schistosoma mansoni glucose transporter 0.0031 0.0151 0.0151
Brugia malayi hypothetical protein 0.0034 0.0174 0.0212
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0066 0.049 0.5359
Mycobacterium ulcerans beta-lactamase 0.008 0.0625 0.2525
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0179 0.0177
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0049 0.0327 0.1453
Plasmodium vivax calcium-dependent protein kinase, putative 0.0068 0.0503 0.0552
Leishmania major trypanothione reductase 0.0098 0.0797 0.2898
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Echinococcus granulosus dna polymerase eta 0.0019 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0561 0.5239 0.5595
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0249 0.2248 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0179 0.0725
Trypanosoma brucei glucose transporter 1E 0.0069 0.0511 0.186
Echinococcus granulosus cpg binding protein 0.0094 0.0752 0.0752
Schistosoma mansoni hypothetical protein 0.0284 0.2575 0.2575
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0511 0.186
Toxoplasma gondii thioredoxin reductase 0.0098 0.0797 0.136
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0066 0.049 0.049
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.1978 0.1978
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0511 0.0533
Loa Loa (eye worm) hypothetical protein 0.008 0.0625 0.0695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.016 0.0333
Onchocerca volvulus 0.0031 0.0151 0.0018
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0625 0.1305
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0151 0.061
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0434 0.158
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0108 0.0108
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0511 0.186
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0033 0.0033
Brugia malayi beta-lactamase family protein 0.008 0.0625 0.0762
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0033 0.0221
Echinococcus granulosus GTP binding nuclear protein Ran 0.0066 0.0482 0.0482
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Leishmania major protein kinase, putative 0.0068 0.0503 0.1829
Brugia malayi jmjC domain containing protein 0.0041 0.0242 0.0295
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0179 0.0187
Loa Loa (eye worm) hypothetical protein 0.0049 0.0327 0.0363
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0151 0.0184
Schistosoma mansoni inositol monophosphatase 0.0036 0.0196 0.0196
Echinococcus granulosus General substrate transporter 0.019 0.1679 0.1679
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0068 0.0503 0.0503
Schistosoma mansoni sugar transporter 0.0031 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0089 0.0708 0.0788
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0482 0.1752
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0776 0.0776
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0797 0.0797
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0224 0.2007 0.4192
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0625 0.1305
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0179 0.0653
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.275 1
Trichomonas vaginalis glucosylceramidase, putative 0.0561 0.5239 0.5595
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0434 0.8786
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0134 0.0134
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0511 0.0533
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0092 0.0102
Treponema pallidum NADH oxidase 0.0034 0.0179 0.286
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.2588 0.2588
Schistosoma mansoni cpg binding protein 0.0089 0.0704 0.0704
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0196 0.0791
Plasmodium vivax proline--tRNA ligase, putative 0.0077 0.0596 0.0656
Leishmania major glucose transporter/membrane transporter D2, putative 0.0069 0.0511 0.186
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.275 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Echinococcus granulosus solute carrier family 22 0.0031 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0029 0.0134 0.0134
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0511 0.0533
Schistosoma mansoni importin beta-1 0.0089 0.0708 0.0708
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0131 0.1112 0.1356
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0066 0.0482 0.1752
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0033 0.0122
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0196 0.0711
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0068 0.0503 0.0552
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0131 0.1112 0.1112
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0151 0.0151
Onchocerca volvulus 0.0031 0.0151 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.3777 0.3777
Plasmodium falciparum proline--tRNA ligase 0.0077 0.0596 0.0656
Leishmania major importin beta-1 subunit, putative 0.0072 0.0546 0.1985
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0066 0.049 0.0597
Mycobacterium tuberculosis Conserved protein 0.008 0.0625 0.1305
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.3386 0.3612
Loa Loa (eye worm) glutaminase 2 0.0273 0.2474 0.2754
Schistosoma mansoni hypothetical protein 0.0131 0.1112 0.1112
Echinococcus multilocularis solute carrier family 22 0.0031 0.0151 0.0151
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0068 0.0503 0.0859
Loa Loa (eye worm) sugar transporter 0.0221 0.1978 0.2202
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.035 0.0598
Schistosoma mansoni importin-beta 2 0.0017 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Schistosoma mansoni sugar transporter 0.0031 0.0151 0.0151
Mycobacterium ulcerans hypothetical protein 0.008 0.0625 0.2525
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0068 0.0503 0.056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0033 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.1065 0.1065
Echinococcus granulosus dnaJ subfamily B 0.0409 0.3777 0.3777
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0179 0.0653
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.049 0.049
Schistosoma mansoni ap endonuclease 0.0061 0.0434 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.1065 0.1065
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Toxoplasma gondii sugar transporter ST2 0.0031 0.0151 0.0258
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0625 0.0625
Toxoplasma gondii sugar transporter ST3 0.0031 0.0151 0.0258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0179 0.0187
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0066 0.0482 0.0482
Entamoeba histolytica hypothetical protein 0.0109 0.0902 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0561 0.5239 0.5831
Plasmodium falciparum calcium-dependent protein kinase 3 0.0068 0.0503 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.3386 0.3612
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0224 0.2007 0.4192
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0066 0.049 0.2179
Onchocerca volvulus 0.0031 0.0151 0.0018
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0151 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0134 0.0134
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0179 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Toxoplasma gondii HEAT repeat-containing protein 0.0089 0.0708 0.1208
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0511 0.186
Brugia malayi RNA binding protein 0.0063 0.046 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Toxoplasma gondii sugar transporter ST1 0.0031 0.0151 0.0258
Entamoeba histolytica Ran family GTPase 0.0066 0.0482 0.5267
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0033 0.0135
Brugia malayi Bromodomain containing protein 0.0029 0.0134 0.0164
Brugia malayi hypothetical protein 0.0031 0.0151 0.0184
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0179 0.0179
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0033 0.007
Trichomonas vaginalis helicase, putative 0.002 0.0045 0.0033
Schistosoma mansoni hypothetical protein 0.1057 1 1
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0212 0.0773
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0546 0.057
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0625 0.2272
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.3386 0.3612
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0196 0.0196
Trypanosoma brucei importin beta-1 subunit, putative 0.0089 0.0708 0.2573
Schistosoma mansoni sugar transporter 0.0031 0.0151 0.0151
Plasmodium falciparum glutathione reductase 0.0098 0.0797 0.0884
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0066 0.0482 0.0536
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0151 0.0151
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.4512 0.4512
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0511 0.0533
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.2325 0.2325
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0415 0.3835 0.4677
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0092 0.0102
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0399 0.0444
Onchocerca volvulus 0.008 0.0625 0.0532
Brugia malayi hypothetical protein 0.0109 0.0902 0.11
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0014 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0561 0.5239 0.5595
Leishmania major DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Onchocerca volvulus 0.0031 0.0151 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.026 0.0944
Echinococcus granulosus GPCR family 2 0.0131 0.1112 0.1112
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0179 0.0653
Plasmodium falciparum thioredoxin reductase 0.0098 0.0797 0.0884
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0131 0.1112 0.1238
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0255 0.0533
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0242 0.0242
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0327 0.0327
Mycobacterium tuberculosis Conserved protein 0.008 0.0625 0.1305
Plasmodium vivax sugar transporter, putative 0.0031 0.0151 0.0155
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.035 0.038
Schistosoma mansoni protein kinase 0.0068 0.0503 0.0503
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1224 0.4449
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.1978 0.1978
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0076 0.0076
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0092 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0063 0.046 0.046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0625 0.1305
Loa Loa (eye worm) latrophilin receptor protein 2 0.0131 0.1112 0.1238
Onchocerca volvulus 0.0031 0.0151 0.0018
Loa Loa (eye worm) RNA binding protein 0.0063 0.046 0.0512
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0434 0.0907
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.02 0.02
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0503 0.0503
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0027 0.0108 0.0108
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.275 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.2588 0.2588
Giardia lamblia Hexose transporter 0.0031 0.0151 0.2575
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0033 0.0135
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0068 0.0503 0.1829
Echinococcus granulosus neuropeptide s receptor 0.0485 0.4512 0.4512
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.1065 0.1065
Leishmania major hypothetical protein, conserved 0.0017 0.0014 0.005
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0196 0.0711
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0224 0.2007 0.4192
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0068 0.0503 0.056
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0151 0.0151
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.4512 0.4512
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.1978 0.1978
Mycobacterium leprae conserved hypothetical protein 0.008 0.0625 0.278
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1378 0.2878
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.1978 0.1978
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0151 0.0147
Plasmodium vivax lysine--tRNA ligase, putative 0.0049 0.0327 0.0353
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0092 0.0102
Leishmania major cytochrome p450-like protein 0.0025 0.0092 0.0333
Brugia malayi major facilitator superfamily protein 0.0031 0.0151 0.0184
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0179 0.0306
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0151 0.0184
Giardia lamblia Prolyl-tRNA synthetase 0.0066 0.049 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Brugia malayi glutathione reductase 0.0098 0.0797 0.0972
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0503 0.0524
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0068 0.0503 0.0552
Trypanosoma brucei sugar transporter, putative 0.0031 0.0151 0.0549
Mycobacterium tuberculosis Probable dehydrogenase 0.0224 0.2007 0.4192
Plasmodium falciparum hexose transporter 0.0221 0.1978 0.2217
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trichomonas vaginalis importin beta-1, putative 0.0072 0.0546 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.2588 0.2588
Schistosoma mansoni ap endonuclease 0.0061 0.0434 0.0434
Toxoplasma gondii lysine-tRNA ligase 0.0049 0.0327 0.0557
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0434 0.1756
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0196 0.2046
Loa Loa (eye worm) hypothetical protein 0.008 0.0625 0.0695
Schistosoma mansoni hypothetical protein 0.0951 0.8984 0.8984
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0033 0.0041
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Giardia lamblia Lysyl-tRNA synthetase 0.0049 0.0327 0.6422
Echinococcus multilocularis transportin 1 0.0017 0.0014 0.0014
Schistosoma mansoni ran 0.0066 0.0482 0.0482
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0434 1
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0797 0.0884
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Plasmodium vivax hypothetical protein, conserved 0.008 0.0625 0.0689
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.035 0.1274
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Giardia lamblia PHD finger protein 15 0.0029 0.0134 0.2205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0179 0.0653
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.1703 0.1703
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0014 0.0015
Echinococcus granulosus transportin 1 0.0017 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0434 0.0475
Plasmodium falciparum protein kinase 6 0.094 0.8875 1
Trypanosoma cruzi hexose transporter 0.0069 0.0511 0.186
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0625 0.0654
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0076 0.0076
Echinococcus multilocularis peregrin 0.0029 0.0134 0.0134
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0179 0.0725
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0033 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.2588 0.2588
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.035 0.038
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0179 0.0187
Brugia malayi Cytochrome P450 family protein 0.0025 0.0092 0.0112
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0596 0.2166
Loa Loa (eye worm) beta-lactamase 0.008 0.0625 0.0695
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.4512 0.4512
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0625 0.2525
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Brugia malayi CXXC zinc finger family protein 0.0089 0.0704 0.0858
Loa Loa (eye worm) TAR-binding protein 0.0063 0.046 0.0512
Onchocerca volvulus 0.008 0.0625 0.0532
Entamoeba histolytica protein kinase, putative 0.0068 0.0503 0.5507
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0151 0.061
Schistosoma mansoni survival motor neuron protein 0.0053 0.0356 0.0356
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0049 0.0327 0.1188
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.1978 0.1978
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0434 0.045
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0151 0.0258
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0327 0.132
Echinococcus granulosus mixed lineage leukemia protein mll 0.0027 0.0108 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Echinococcus multilocularis General substrate transporter 0.019 0.1679 0.1679
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Schistosoma mansoni glucose transport protein 0.0221 0.1978 0.1978
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0249 0.2248 0.4694
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0151 0.0168
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0503 0.0503
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0327 0.0327
Onchocerca volvulus 0.0089 0.0704 0.0618
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Schistosoma mansoni glucose transport protein 0.0221 0.1978 0.1978
Mycobacterium ulcerans sugar transporter 0.0031 0.0151 0.061
Trichomonas vaginalis glucosylceramidase, putative 0.0561 0.5239 0.5595
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0561 0.5239 0.6388
Plasmodium falciparum calcium-dependent protein kinase 5 0.0068 0.0503 0.0552
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0066 0.0482 0.0822
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0434 0.0475
Onchocerca volvulus 0.0053 0.0356 0.0241
Brugia malayi Sugar transporter family protein 0.0031 0.0151 0.0184
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Mycobacterium ulcerans hypothetical protein 0.0159 0.1378 0.5571
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0033 0.0033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0131 0.1112 0.1112
Loa Loa (eye worm) hypothetical protein 0.0052 0.035 0.039
Plasmodium falciparum protein kinase 7 0.0625 0.5858 0.6596
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0902 0.0902
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0349 0.1268
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0511 0.186
Echinococcus multilocularis lysyl tRNA synthetase 0.0049 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Schistosoma mansoni hypothetical protein 0.0053 0.0356 0.0356
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0285 0.2588 0.3156
Onchocerca volvulus 0.0031 0.0151 0.0018
Brugia malayi Sugar transporter family protein 0.0221 0.1978 0.2412
Leishmania major hypothetical protein, conserved 0.0031 0.0151 0.0549
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0066 0.049 0.0597
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0033
Mycobacterium ulcerans glutaminase 0.0273 0.2474 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.7633 0.7633
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0625 0.1305
Onchocerca volvulus 0.0031 0.0151 0.0018
Schistosoma mansoni hypothetical protein 0.0131 0.1112 0.1112
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0068 0.0503 0.0613
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0049 0.0327 0.1188
Echinococcus multilocularis solute carrier family 22 0.0031 0.0151 0.0151
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0797 0.0797
Trichomonas vaginalis glucosylceramidase, putative 0.0561 0.5239 0.5595
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0951 0.8984 1
Schistosoma mansoni glutaminase 0.0273 0.2474 0.2474
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.3386 0.3612
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0068 0.0503 0.0552
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0179 0.4098
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0066 0.049 0.049
Echinococcus multilocularis calcium dependent protein kinase 0.0064 0.0463 0.0463
Schistosoma mansoni inositol monophosphatase 0.0036 0.0196 0.0196
Trichomonas vaginalis ran, putative 0.0066 0.0482 0.0501
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0245 0.0245
Leishmania major hypothetical protein, conserved 0.008 0.0625 0.2272
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0018 0.0018
Brugia malayi TAR-binding protein 0.0063 0.046 0.0561
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0869 0.82 0.9127
Entamoeba histolytica hypothetical protein 0.0049 0.0327 0.3521
Leishmania major glucose transporter, lmgt2 0.0069 0.0511 0.186
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0434 0.0434
Schistosoma mansoni hypothetical protein 0.0409 0.3777 0.3777
Echinococcus granulosus solute carrier family 22 0.0031 0.0151 0.0151
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Leishmania major glucose transporter, lmgt3 0.0069 0.0511 0.186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0625 0.2272
Plasmodium falciparum thioredoxin reductase 0.0034 0.0179 0.0187
Plasmodium vivax importin-beta 2, putative 0.0089 0.0708 0.0783
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0037 0.0203 0.0203
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0134 0.0134
Trypanosoma brucei glucose transporter 2A 0.0069 0.0511 0.186
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0043 0.0268 0.0272
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0625 0.1305
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0196 0.0195
Onchocerca volvulus 0.008 0.0625 0.0532
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0902 0.0902
Entamoeba histolytica hypothetical protein 0.0109 0.0902 1
Schistosoma mansoni glucose transport protein 0.0221 0.1978 0.1978
Entamoeba histolytica protein kinase, putative 0.0068 0.0503 0.5507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Schistosoma mansoni sugar transporter 0.0031 0.0151 0.0151
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0014 0.005
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0151 0.0549
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0033 0.007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0596 0.2166
Mycobacterium tuberculosis Probable reductase 0.0224 0.2007 0.4192
Trichomonas vaginalis glucosylceramidase, putative 0.0368 0.3386 0.3612
Chlamydia trachomatis lysine--tRNA ligase 0.0049 0.0327 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0066 0.0482 0.0528
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0179 0.0306
Echinococcus granulosus lysyl tRNA synthetase 0.0049 0.0327 0.0327
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0045 0.0033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0248 0.0303
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.016 0.016
Leishmania major hypothetical protein, conserved 0.0052 0.035 0.1274
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0151 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0242 0.0269
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.1065 0.1065
Schistosoma mansoni hypothetical protein 0.0131 0.1112 0.1112
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.035 0.038
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0245 0.0245
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0066 0.0482 0.0587
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Echinococcus granulosus translational activator gcn1 0.0017 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.1978 0.2103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.1065 0.1065
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0033 0.0021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.016 0.071
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.1003 0.1003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1224 0.4449
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.035 0.1274
Toxoplasma gondii facilitative glucose transporter GT1 0.0221 0.1978 0.3376
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0151 0.0315
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0049 0.0327 0.0335
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0014 0.0024
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0179 0.0187
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0797 0.1664
Plasmodium vivax SET domain protein, putative 0.0126 0.1065 0.1187
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0625 0.0654
Echinococcus granulosus importin subunit beta 1 0.0089 0.0708 0.0708
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.2588 0.2588
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0503 0.0503
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1224 0.4449
Onchocerca volvulus Glucosylceramidase homolog 0.0368 0.3386 0.3528
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Brugia malayi lysyl-tRNA synthetase 0.0049 0.0327 0.0398
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0179 0.0219
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0068 0.0503 0.0859
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0625 0.0654
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0503 0.0503
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Onchocerca volvulus 0.0031 0.0151 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0134 0.0229
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Brugia malayi Pre-SET motif family protein 0.0126 0.1065 0.1299
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0511 0.0533
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0068 0.0503 0.056
Plasmodium falciparum phd finger protein, putative 0.0029 0.0134 0.0136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0434 0.158
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0511 0.0533
Trichomonas vaginalis esterase, putative 0.008 0.0625 0.0654
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0179 0.32
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0151 0.0151
Plasmodium falciparum calcium-dependent protein kinase 1 0.0068 0.0503 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0179 0.0653
Loa Loa (eye worm) inositol-1 0.0036 0.0196 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.035 0.1274
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0151 0.0549
Loa Loa (eye worm) hypothetical protein 0.008 0.0625 0.0695
Schistosoma mansoni hypothetical protein 0.0131 0.1112 0.1112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.2588 0.2588
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0625 0.0695
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0511 0.0533
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0415 0.3835 0.4268
Onchocerca volvulus Putative transporter 0.0031 0.0151 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0434 0.045
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Brugia malayi Thioredoxin reductase 0.0098 0.0797 0.0972
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0242 0.0242
Toxoplasma gondii exonuclease III APE 0.0061 0.0434 0.0742
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0776 0.0776
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0033 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0388 0.3577 0.3816
Onchocerca volvulus 0.0031 0.0151 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.2588 0.2588
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.016 0.016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.026 0.0944
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0131 0.1112 0.1112
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Mycobacterium tuberculosis Probable oxidoreductase 0.0249 0.2248 0.4694
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0037 0.0203 0.0738
Leishmania major glucose transporter, lmgt1 0.0069 0.0511 0.186
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0503 0.0503
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0179 0.1006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0093 0.0113
Echinococcus granulosus tar DNA binding protein 0.0063 0.046 0.046
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0151 0.0549
Trypanosoma brucei unspecified product 0.0019 0.0033 0.0122
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0434 0.4735
Brugia malayi major facilitator superfamily protein 0.0031 0.0151 0.0184
Brugia malayi PHD-finger family protein 0.0029 0.0134 0.0164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0625 0.0625
Giardia lamblia Sugar-proton symporter 0.0031 0.0151 0.2575
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.275 1
Trichomonas vaginalis set domain proteins, putative 0.0989 0.9351 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.037 0.0412
Brugia malayi hypothetical protein 0.0257 0.2325 0.2835
Echinococcus multilocularis cpg binding protein 0.0094 0.0752 0.0752
Loa Loa (eye worm) histone methyltransferase 0.0032 0.016 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.1065 0.1065
Onchocerca volvulus 0.0031 0.0151 0.0018
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0151 0.0151
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0482 0.1752
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0179 0.0177
Loa Loa (eye worm) hypothetical protein 0.0257 0.2325 0.2587
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0045 0.0033
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0045 0.0033
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0356 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Onchocerca volvulus 0.0031 0.0151 0.0018
Echinococcus multilocularis solute carrier family 22 0.0031 0.0151 0.0151
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0033 0.0122
Onchocerca volvulus 0.0031 0.0151 0.0018
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0179 0.0725
Onchocerca volvulus 0.0031 0.0151 0.0018
Echinococcus multilocularis tar DNA binding protein 0.0063 0.046 0.046
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0033 0.0033
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0224 0.2007 0.4192
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0066 0.049 0.051
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0179 0.0653
Entamoeba histolytica hypothetical protein 0.0109 0.0902 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0151 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0021 0.0055 0.0198
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0196 0.0195
Plasmodium vivax CDK-related protein kinase 6, putative 0.094 0.8875 1
Loa Loa (eye worm) glutathione reductase 0.0098 0.0797 0.0887
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0151 0.0184
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0625 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Schistosoma mansoni protein kinase 0.0068 0.0503 0.0503
Onchocerca volvulus 0.0989 0.9351 1
Plasmodium vivax hexose transporter 0.0221 0.1978 0.2217
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0151 0.061
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0503 0.0503
Toxoplasma gondii hypothetical protein 0.0049 0.0319 0.0545
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0434 0.0434
Echinococcus granulosus solute carrier family 22 0.0031 0.0151 0.0151
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.0434 1
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0434 0.053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0625 0.2525
Onchocerca volvulus 0.0031 0.0151 0.0018
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0068 0.0503 0.0859
Brugia malayi hypothetical protein 0.0052 0.035 0.0427
Mycobacterium ulcerans lipase LipD 0.008 0.0625 0.2525
Onchocerca volvulus 0.0126 0.1065 0.101
Onchocerca volvulus 0.0031 0.0151 0.0018
Brugia malayi glutaminase DH11.1 0.0273 0.2474 0.3017
Schistosoma mansoni cpg binding protein 0.0094 0.0752 0.0752
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0625 0.0654
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0179 0.0653
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0092 0.0333
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0066 0.0482 0.0528
Echinococcus multilocularis translational activator gcn1 0.0017 0.0014 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0625 0.1305
Echinococcus granulosus dna polymerase kappa 0.0019 0.0033 0.0033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0196 0.0195
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.1065 0.1819
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0327 0.132
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0358 0.3287 0.3694
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Schistosoma mansoni cpg binding protein 0.0094 0.0752 0.0752
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0625 0.0625
Entamoeba histolytica hypothetical protein 0.0109 0.0902 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0434 0.158
Mycobacterium leprae Probable lipase LipE 0.008 0.0625 0.278
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.026 0.0944
Onchocerca volvulus 0.0031 0.0151 0.0018
Echinococcus granulosus sodium channel protein 0.0037 0.0203 0.0203
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0255 0.1135
Brugia malayi hypothetical protein 0.0031 0.0151 0.0184
Brugia malayi Importin beta-1 subunit 0.0089 0.0708 0.0863
Brugia malayi jmjC domain containing protein 0.0096 0.0776 0.0946
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0134 0.0229
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0511 0.186
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0045 0.0033
Loa Loa (eye worm) hypothetical protein 0.008 0.0625 0.0695
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0434 0.0484
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.1978 0.1978
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Schistosoma mansoni protein kinase 0.0068 0.0503 0.0503
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0704 0.0783
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0168
Schistosoma mansoni DNA polymerase eta 0.0019 0.0033 0.0033
Brugia malayi beta-lactamase 0.008 0.0625 0.0762
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.1978 0.1978
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0014 0.0024
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0033 0.0122
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0114 0.0127
Echinococcus multilocularis importin subunit beta 1 0.0089 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0066 0.049 0.0545
Toxoplasma gondii protein kinase, putative 0.0625 0.5858 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0151 0.0155
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0077 0.0596 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0151 0.0147
Echinococcus multilocularis importin 5 0.0017 0.0014 0.0014
Echinococcus multilocularis solute carrier family 22 0.0031 0.0151 0.0151
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0092 0.037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Brugia malayi kap beta 3 protein 0.0017 0.0014 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0249 0.2248 0.4694
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0033 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0063 0.046 0.046
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0503 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0033 0.0122
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0179 0.1006
Schistosoma mansoni hypothetical protein 0.0109 0.0902 0.0902
Brugia malayi Inositol-1 0.0036 0.0196 0.0239
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0077 0.0313
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0625 0.1305
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0434 0.0483
Loa Loa (eye worm) hypothetical protein 0.008 0.0625 0.0695
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0797 0.0887
Loa Loa (eye worm) hypothetical protein 0.0066 0.049 0.0545
Echinococcus multilocularis sodium channel protein 0.0037 0.0203 0.0203
Brugia malayi hypothetical protein 0.0031 0.0151 0.0184
Echinococcus multilocularis GPCR, family 2 0.0131 0.1112 0.1112
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0193 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0063 0.046 0.046
Trypanosoma brucei glucose transporter, putative 0.0069 0.0511 0.186
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0196 0.0196
Trypanosoma cruzi importin beta-1 subunit, putative 0.0072 0.0546 0.1985
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.046 0.0512
Entamoeba histolytica hypothetical protein 0.0072 0.0546 0.5988
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0151 0.0147
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0514 0.4789 1
Toxoplasma gondii ABC1 family protein 0.008 0.0625 0.1067
Brugia malayi Cam kinase protein 1 0.0068 0.0503 0.0613
Brugia malayi Pre-SET motif family protein 0.0869 0.82 1
Mycobacterium tuberculosis Conserved protein 0.008 0.0625 0.1305
Leishmania major lysyl-tRNA synthetase, putative 0.0049 0.0327 0.1188
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0374
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0179 0.0653
Echinococcus multilocularis geminin 0.1057 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0089 0.0708 0.2573

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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