Detailed information for compound 1554068

Basic information

Technical information
  • TDR Targets ID: 1554068
  • Name: T5580890
  • MW: 329.394 | Formula: C18H23N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CNC(=O)CN1C(=O)NC2(C1=O)CCCc1c2cccc1)C
  • InChi: 1S/C18H23N3O3/c1-12(2)10-19-15(22)11-21-16(23)18(20-17(21)24)9-5-7-13-6-3-4-8-14(13)18/h3-4,6,8,12H,5,7,9-11H2,1-2H3,(H,19,22)(H,20,24)
  • InChiKey: UKBZVRCIHDWSMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0311 0.1582
Onchocerca volvulus 0.0232 0.0503 0.2247
Loa Loa (eye worm) hypothetical protein 0.0155 0.0327 0.1664
Trypanosoma cruzi ISWI complex protein 0.0031 0.0043 0.0381
Echinococcus granulosus ring and YY1 binding protein 0.0082 0.0161 0.1016
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0026 0.0035
Onchocerca volvulus 0.0034 0.0051 0.0227
Schistosoma mansoni fusion 0.0082 0.0161 0.1016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0146 0.092
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0107 0.0675
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0139 0.0873
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0026 0.0162
Echinococcus multilocularis SWI:SNF matrix associated 0.0232 0.0503 0.069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0139 0.0706
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0105 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Brugia malayi Bromodomain containing protein 0.0152 0.0322 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0139 0.0706
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Mycobacterium tuberculosis Conserved protein 0.0109 0.0223 0.0201
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Mycobacterium ulcerans beta-lactamase 0.0109 0.0223 0.0201
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0061
Loa Loa (eye worm) TK/EGFR protein kinase 0.0418 0.093 0.4735
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0026 0.0116
Loa Loa (eye worm) beta-lactamase 0.0109 0.0223 0.1136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0082 0.016 0.0815
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0138 0.0189
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0223 0.0887
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.008 0.0109
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0051 0.0259
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0045 0.0421
Brugia malayi Protein kinase domain containing protein 0.0089 0.0176 0.0894
Echinococcus granulosus dnaJ subfamily B 0.0397 0.0881 0.5557
Toxoplasma gondii exonuclease III APE 0.0058 0.0105 0.0105
Mycobacterium ulcerans hypothetical protein 0.0109 0.0223 0.0201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0338 0.2131
Echinococcus multilocularis epidermal growth factor receptor 0.0258 0.0563 0.0773
Schistosoma mansoni glutaminase 0.0271 0.0593 0.3738
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0026 0.0162
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0026 0.0162
Echinococcus granulosus SWI:SNF matrix associated 0.0232 0.0503 0.3175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus epidermal growth factor receptor 0.0418 0.093 0.587
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0161 0.3082
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0087 0.0173 0.0878
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0446 1
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0026 0.0162
Onchocerca volvulus 0.0155 0.0327 0.1459
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Brugia malayi hypothetical protein 0.0038 0.006 0.0307
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0223 0.0201
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0051 0.0319
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0139 0.0706
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0105 0.0534
Schistosoma mansoni adenoreceptor 0.0023 0.0026 0.0162
Echinococcus granulosus epidermal growth factor receptor 0.0258 0.0563 0.3553
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0105 0.2085
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0026 0.0162
Onchocerca volvulus Tyrosine kinase homolog 0.0173 0.037 0.1651
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0161 0.3208
Loa Loa (eye worm) hypothetical protein 0.0148 0.0311 0.1582
Trypanosoma brucei ISWI complex protein 0.0031 0.0043 0.0202
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0026 0.0132
Brugia malayi MH2 domain containing protein 0.0122 0.0252 0.1285
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0223 0.0201
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0258 0.0563 0.3553
Trypanosoma cruzi WLM domain containing protein, putative 0.0082 0.0161 0.3208
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0027 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0082 0.0161 0.3208
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0076 0.0223
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0026 0.0132
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0232 0.0503 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0035 0.0178
Schistosoma mansoni coup transcription factor 0.0073 0.0139 0.0873
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0105 0.1861
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0045 0.0022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Brugia malayi G protein-coupled receptor 0.0023 0.0026 0.0132
Schistosoma mansoni hypothetical protein 0.0232 0.0503 0.3175
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0082 0.0161 0.3205
Brugia malayi nuclear receptor NHR-88 0.0034 0.0051 0.0259
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Onchocerca volvulus 0.0109 0.0223 0.0997
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0026 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0167 0.0633
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0259 0.0356
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0105 0.0144
Onchocerca volvulus 0.0073 0.0139 0.0619
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0223 0.0201
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0139 0.0619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0521 0.3289
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.0446 1
Echinococcus granulosus roundabout 2 0.0022 0.0022 0.0138
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0023 0.0031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3193 0.7285 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0105 0.171
Schistosoma mansoni hypothetical protein 0.0232 0.0503 0.3175
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0026 0.0035
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0051 0.0319
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0521 0.3289
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0013 0.0003 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0139 0.0706
Brugia malayi AKH receptor 0.0023 0.0026 0.0132
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0265 0.058 0.0796
Mycobacterium tuberculosis Conserved protein 0.0024 0.0027 0.0004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0026 0.0162
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0537 0.2733
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.008 0.05
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0051 0.0319
Toxoplasma gondii ran binding protein 0.0082 0.0161 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0139 0.0706
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0026 0.0162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0026 0.0162
Leishmania major hypothetical protein, conserved 0.0031 0.0043 0.0381
Onchocerca volvulus 0.0023 0.0026 0.0116
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0232 0.0503 1
Onchocerca volvulus 0.016 0.034 0.1516
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0026 0.0132
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0051 0.0069
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0699 0.1574 0.1555
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0082 0.0161 0.3082
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0051 0.0319
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0051 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0139 0.0706
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0105 0.0352
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0045 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Brugia malayi steroid hormone receptor 0.0073 0.0139 0.0706
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0107 0.0675
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0026 0.0035
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Schistosoma mansoni hypothetical protein 0.0082 0.0161 0.1016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0182 0.025
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0026 0.0132
Loa Loa (eye worm) glutaminase 0.0271 0.0593 0.3016
Brugia malayi hypothetical protein 0.0038 0.006 0.0307
Brugia malayi neuropeptide F receptor 0.0023 0.0026 0.0132
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0139 0.019
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0051 0.0259
Onchocerca volvulus 0.0023 0.0026 0.0116
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Schistosoma mansoni biogenic amine receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0139 0.019
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Giardia lamblia Kinase, PLK 0.0092 0.0182 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0139 0.0706
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Brugia malayi Latrophilin receptor protein 2 0.0047 0.008 0.0405
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0027 0.0168
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0107 0.1919
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0139 0.019
Schistosoma mansoni histamine h1 receptor 0.0023 0.0026 0.0162
Brugia malayi ecdysone receptor 0.0034 0.0051 0.0259
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.087 0.1964 1
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0223 0.0201
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0026 0.0035
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.008 0.0502
Schistosoma mansoni hypothetical protein 0.0031 0.0043 0.0269
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0026 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0051 0.0319
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0248 0.156
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0051 0.0259
Echinococcus granulosus fmrfamide receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis zinc finger protein Ran binding 0.0082 0.0161 0.0221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.0521 0.3289
Brugia malayi G-protein coupled receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis zinc finger protein 0.0041 0.0066 0.009
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0051 0.0259
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0105 0.5
Brugia malayi nuclear hormone receptor 0.0073 0.0139 0.0706
Schistosoma mansoni hypothetical protein 0.0704 0.1584 1
Plasmodium vivax hypothetical protein, conserved 0.0232 0.0503 1
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0026 0.0035
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0223 0.1136
Echinococcus granulosus histone lysine methyltransferase setb 0.016 0.0338 0.2131
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0051 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0139 0.0873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0139 0.0706
Onchocerca volvulus 0.0023 0.0026 0.0116
Brugia malayi CHE-14 protein 0.0085 0.0167 0.085
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0027 0.0004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Brugia malayi neuropeptide F receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Mycobacterium ulcerans lipase LipD 0.0109 0.0223 0.0201
Echinococcus granulosus GPCR family 2 0.0047 0.008 0.05
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0182 0.1148
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0026 0.0035
Brugia malayi nuclear hormone receptor 0.0034 0.0051 0.0259
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0026 0.0132
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Echinococcus granulosus zinc finger protein 0.0041 0.0066 0.0416
Onchocerca volvulus 0.0082 0.0161 0.072
Brugia malayi Pre-SET motif family protein 0.087 0.1964 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0026 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0259 0.1635
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0051 0.0227
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0026 0.0162
Schistosoma mansoni bromodomain containing protein 0.0129 0.0268 0.1687
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0161 0.3082
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0223 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0076 0.0223
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0061
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.062 0.3915
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0026 0.0035
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni tyrosine kinase 0.0017 0.0011 0.0065
Brugia malayi nuclear receptor RXR 0.0034 0.0051 0.0259
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0026 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0107 0.0085
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0051 0.0069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus granulosus sex peptide receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0122 0.0251 0.0344
Echinococcus multilocularis SWI:SNF matrix associated 0.0232 0.0503 0.069
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0035 0.0035
Brugia malayi ecdysteroid receptor 0.0073 0.0139 0.0706
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.006 0.0378
Trichomonas vaginalis set domain proteins, putative 0.099 0.2239 1
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0223 0.4686
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0027 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0311 0.1582
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0026 0.0162
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0104 0.0211 0.1073
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.062 0.0851
Schistosoma mansoni cell adhesion molecule 0.0014 0.0005 0.0031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0223 0.0201
Brugia malayi nuclear receptor NHR-88 0.0073 0.0139 0.0706
Echinococcus granulosus zinc finger protein Ran binding 0.0082 0.0161 0.1016
Schistosoma mansoni nuclear receptor 0.0034 0.0051 0.0319
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0045 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0139 0.0619
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0014 0.0005 0.0031
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0167 0.0229
Brugia malayi conserved hypotetical protein 0.0034 0.0051 0.0259
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0026 0.0035
Echinococcus granulosus twitchin 0.0018 0.0015 0.0091
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0035 0.0688
Brugia malayi Furin-like cysteine rich region family protein 0.0418 0.093 0.4735
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0107 0.0085
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0026 0.0035
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0026 0.0162
Schistosoma mansoni tyrosine kinase 0.0265 0.058 0.3661
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0051 0.0319
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.4379 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0167 0.085
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0026 0.0162
Onchocerca volvulus 0.0028 0.0036 0.0162
Loa Loa (eye worm) hypothetical protein 0.0142 0.0298 0.1518
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0026 0.0035
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0026 0.0035
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0105 0.0352
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.0405
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0146 0.092
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.0182
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0161 0.3208
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0026 0.0162
Brugia malayi sulfakinin receptor protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0026 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0139 0.0706
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0045 0.0421
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0045 0.0279
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0026 0.0162
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0265 0.058 0.3661
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0107 0.0107
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0026 0.0162
Echinococcus multilocularis geminin 0.0704 0.1584 0.2175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0154 0.0325 0.0303
Brugia malayi GnHR receptor homolog 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0082 0.0161 0.3208
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0026 0.0162
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0154 0.0325 0.0303
Brugia malayi hypothetical protein 0.0034 0.0051 0.0259
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0107 0.0675
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0139 0.0706
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.0688
Schistosoma mansoni RNA binding protein 0.0082 0.0161 0.1016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0118 0.0744
Onchocerca volvulus 0.0109 0.0223 0.0997
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0026 0.0035
Trypanosoma brucei polo-like protein kinase 0.0092 0.0182 0.359
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0051 0.0259
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0026 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0138 0.0869
Echinococcus multilocularis expressed conserved protein 0.0186 0.0398 0.0546
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni ap endonuclease 0.0058 0.0105 0.066
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0051 0.007
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0182 0.0928
Schistosoma mansoni zinc finger protein 0.0031 0.0043 0.0269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0051 0.0319
Schistosoma mansoni ap endonuclease 0.0058 0.0105 0.066
Mycobacterium ulcerans hypothetical protein 0.0024 0.0027 0.0004
Brugia malayi hypothetical protein 0.0155 0.0327 0.1664
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus insulin receptor 0.0265 0.058 0.3661
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0026 0.0162
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0105 0.0534
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.006 0.0378
Schistosoma mansoni tyrosine kinase 0.0252 0.055 0.3469
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0139 0.0619
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0082 0.0161 0.3208
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0026 0.0132
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0537 0.2733
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Brugia malayi brahma associated protein 60 kDa 0.0232 0.0503 0.2562
Leishmania major hypothetical protein, conserved 0.0207 0.0446 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0139 0.0706
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0026 0.0162
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0026 0.0132
Schistosoma mansoni biogenic amine receptor 0.0023 0.0026 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0223 0.0887
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0026 0.0162
Schistosoma mansoni zinc finger protein 0.0034 0.0051 0.0319
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0026 0.0132
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Schistosoma mansoni zinc finger protein 0.0041 0.0066 0.0416
Onchocerca volvulus 0.0023 0.0026 0.0116
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0023 0.0031
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0232 0.0503 0.2562
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) TK protein kinase 0.0013 0.0003 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0161 0.3208
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0107 0.0147
Echinococcus granulosus neuroglian 0.0018 0.0014 0.0087
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0139 0.0873
Onchocerca volvulus 0.0023 0.0026 0.0116
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0051 0.0259
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0146 0.02
Loa Loa (eye worm) DR-78 0.0034 0.0051 0.0259
Schistosoma mansoni hypothetical protein 0.0082 0.016 0.1008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0082 0.0161 0.072
Echinococcus multilocularis serotonin receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0167 0.085
Onchocerca volvulus 0.0023 0.0026 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0338 0.2131
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0139 0.0873
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0023 0.014
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.0182
Schistosoma mansoni hypothetical protein 0.0232 0.0503 0.3175
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0105 0.2085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0139 0.0706
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0068 0.0344
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni tyrosine kinase 0.0258 0.0563 0.3553
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.008 0.0502
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0026 0.0162
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0026 0.0162
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Onchocerca volvulus 0.0023 0.0026 0.0116
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.006 0.0082
Schistosoma mansoni nephrin 0.0018 0.0014 0.0087
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0051 0.0319
Schistosoma mansoni cpg binding protein 0.0033 0.0049 0.0305
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.008 0.0405
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0026 0.0035
Brugia malayi Dopamine receptor protein 2 0.0023 0.0026 0.0132
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0223 0.1136
Echinococcus granulosus allatostatin A receptor 0.0023 0.0026 0.0162
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0182 0.0814
Onchocerca volvulus 0.099 0.2239 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Brugia malayi SWIB/MDM2 domain containing protein 0.0232 0.0503 0.2562
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0139 0.019
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0426 0.0584
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0026 0.0035
Echinococcus granulosus neuropeptide receptor 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0139 0.0706
Brugia malayi Cytochrome P450 family protein 0.0027 0.0035 0.0178
Echinococcus multilocularis sex peptide receptor 0.0023 0.0026 0.0035
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0051 0.0259
Brugia malayi putative neuropeptide receptor 0.0023 0.0026 0.0132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.008 0.05
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus granulosus Aminotransferase class III 0.0022 0.0023 0.014
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0139 0.0873
Brugia malayi glutaminase DH11.1 0.0271 0.0593 0.3016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni tyrosine kinase 0.0258 0.0563 0.3553
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0154 0.0325 0.0303
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0125 0.0259 0.1635
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Onchocerca volvulus 0.0082 0.0161 0.072
Onchocerca volvulus 0.0082 0.0161 0.072
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0051 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0051 0.0069
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0139 0.0706
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0026 0.0035
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0154 0.0325 0.1347
Echinococcus granulosus expressed conserved protein 0.0186 0.0398 0.2513
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0105 0.066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0223 0.1407
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0167 0.1052
Schistosoma mansoni tyrosine kinase 0.0252 0.055 0.3469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.016 0.0338 0.0463
Trypanosoma cruzi ISWI complex protein 0.0031 0.0043 0.0381
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0232 0.0503 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.0521 0.2654
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0026 0.0162
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0082 0.0161 0.0821
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0107 0.0085
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0026 0.0035
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0026 0.0162
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Echinococcus multilocularis somatostatin receptor 0.0023 0.0026 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.0386 0.1963
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0023 0.0449
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0026 0.0116
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.008 0.0109
Schistosoma mansoni cpg binding protein 0.0028 0.0036 0.0227
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi larval opioid receptor 0.0023 0.0026 0.0132
Echinococcus multilocularis protein dispatched 1 0.0097 0.0195 0.0267
Schistosoma mansoni cpg binding protein 0.0033 0.0049 0.0305
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0026 0.0132
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0139 0.019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Brugia malayi Dopamine receptor protein 1 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni zinc finger protein 0.0082 0.0161 0.1016
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0109 0.0223 0.1136
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0223 0.0306
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0045 0.0227
Echinococcus multilocularis epidermal growth factor receptor 0.0418 0.093 0.1277
Brugia malayi Melatonin receptor type 1A 0.0023 0.0026 0.0132
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0426 0.2168
Echinococcus granulosus hypothetical protein 0.0023 0.0026 0.0162
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0139 0.0873
Mycobacterium tuberculosis Conserved protein 0.0109 0.0223 0.0201
Echinococcus multilocularis cpg binding protein 0.0033 0.0049 0.0066
Echinococcus granulosus g protein coupled receptor 0.0023 0.0026 0.0162
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0105 0.0083
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.0881 0.1208
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0026 0.0035
Schistosoma mansoni neuropeptide receptor 0.0023 0.0026 0.0162
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0082 0.0161 0.3208
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Echinococcus granulosus serotonin receptor 0.0023 0.0026 0.0162
Brugia malayi nuclear receptor NHR-67 0.0034 0.0051 0.0259
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0223 0.0201
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0139 0.0873
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0139 0.0873
Brugia malayi beta-lactamase 0.0109 0.0223 0.1136
Echinococcus multilocularis 0.0127 0.0264 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Pre-SET motif family protein 0.0125 0.0259 0.1321
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0223 0.0887
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0026 0.0162
Brugia malayi isocitrate dehydrogenase 0.0031 0.0045 0.0227
Echinococcus granulosus g protein coupled receptor 0.0023 0.0026 0.0162
Schistosoma mansoni hypothetical protein 0.0704 0.1584 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0023 0.014
Brugia malayi RE15519p 0.0023 0.0026 0.0132
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0139 0.0873
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.006 0.0307
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0433 0.2731
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0139 0.0706
Brugia malayi Serotonin receptor 0.0023 0.0026 0.0132
Brugia malayi hypothetical protein 0.0018 0.0013 0.0064
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.006 0.0378
Schistosoma mansoni tyrosine kinase 0.0418 0.093 0.587
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0139 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Schistosoma mansoni opsin-like receptor 0.0023 0.0026 0.0162
Schistosoma mansoni kinase 0.0047 0.0079 0.0497
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0139 0.019
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0027 0.0004
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0003 0.0014
Onchocerca volvulus 0.0023 0.0026 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0223 0.4435
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Brugia malayi Dopamine receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0051 0.0259
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0003 0.0015
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.006 0.0307
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0026 0.0132
Mycobacterium ulcerans hypothetical protein 0.0154 0.0325 0.0303
Echinococcus multilocularis protein patched 0.0085 0.0167 0.0229
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0051 0.0319
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0113
Brugia malayi PHD-finger family protein 0.0052 0.0091 0.0463
Onchocerca volvulus 0.0023 0.0026 0.0116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Loa Loa (eye worm) hypothetical protein 0.016 0.0338 0.172
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0026 0.0162
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0026 0.0162
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0182 0.3707
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0026 0.0132
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0182 0.3707
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0503 0.2153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0232 0.0503 0.069
Loa Loa (eye worm) hypothetical protein 0.0101 0.0204 0.1037
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0051 0.0227
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.4379 1 1
Onchocerca volvulus 0.0023 0.0026 0.0116
Brugia malayi YY1-associated factor 2 0.0082 0.0161 0.0821
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0223 0.0201
Brugia malayi Serotonin receptor 0.0023 0.0026 0.0132
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.008 0.0405
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0223 0.1407
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0045 0.0887
Echinococcus multilocularis SWI:SNF matrix associated 0.0232 0.0503 0.069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0162
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0026 0.0035
Onchocerca volvulus 0.0109 0.0223 0.0997
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0082 0.0161 0.3082
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.006 0.0307
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0223 0.4588
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0139 0.019
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0139 0.0873
Schistosoma mansoni nuclear receptor 0.0034 0.0051 0.0319
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0139 0.0706
Echinococcus granulosus Zinc finger RanBP2 type 0.0082 0.0161 0.1016
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Schistosoma mansoni hypothetical protein 0.0041 0.0068 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0232 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0077 0.0149 0.076
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0045 0.0061
Loa Loa (eye worm) TK/ROR protein kinase 0.0013 0.0003 0.0014
Echinococcus multilocularis insulin receptor 0.0265 0.058 0.0796
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0223 0.4686
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0051 0.0069
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0023 0.0023
Brugia malayi nuclear receptor RXR 0.0038 0.006 0.0307
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0026 0.0162
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0105 0.1861
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Echinococcus multilocularis roundabout 2 0.0022 0.0022 0.003
Toxoplasma gondii pantoate-beta-alanine ligase 0.4379 1 1
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Bromodomain containing protein 0.0077 0.0149 0.0758
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0023 0.0115
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0521 0.0715
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0026 0.0162
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0082 0.0161 0.0161
Schistosoma mansoni TRABID protein (C64 family) 0.0082 0.0161 0.1016
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0521 0.3289
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi ORL1-like opioid receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0054 0.0274
Brugia malayi hypothetical protein 0.0076 0.0146 0.0744
Schistosoma mansoni tyrosine kinase 0.0252 0.055 0.3469
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0182 0.1148
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0232 0.0503 0.3175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0139 0.0706
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0122 0.0251 0.1583
Leishmania major hypothetical protein, conserved 0.0109 0.0223 0.4686
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0223 0.1407
Schistosoma mansoni myosin xvIII 0.0023 0.0026 0.0162
Chlamydia trachomatis DNA topoisomerase I 0.0232 0.0503 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Toxoplasma gondii ABC1 family protein 0.0109 0.0223 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0223 0.0887
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0011 0.0057
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0026 0.0162
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0082 0.0161 0.1016
Loa Loa (eye worm) hypothetical protein 0.0082 0.0161 0.0821
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0182 0.3707
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0026 0.0035
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0426 0.2686
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0446 1
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0139 0.0873
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0027
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0045 0.0243
Schistosoma mansoni hypothetical protein 0.0397 0.0881 0.5557
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0026 0.0035
Mycobacterium leprae Probable lipase LipE 0.0109 0.0223 0.0201
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0026 0.0035
Schistosoma mansoni hypothetical protein 0.0076 0.0146 0.092
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0023 0.0449
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0252 0.1285
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0252 0.1285
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Brugia malayi hypothetical protein 0.0034 0.0051 0.0259
Echinococcus granulosus orexin receptor type 2 0.0023 0.0026 0.0162
Onchocerca volvulus 0.0023 0.0026 0.0116
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0167 0.1052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.0521 0.3289
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0026 0.0035
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0139 0.0706
Brugia malayi CXXC zinc finger family protein 0.0028 0.0036 0.0185
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.0307
Echinococcus multilocularis ring and YY1 binding protein 0.0082 0.0161 0.0221
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.0521 0.2654
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0036 0.0185
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0259 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.0521 0.0715
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0223 0.0201
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0051 0.032
Schistosoma mansoni brg-1 associated factor 0.0232 0.0503 0.3175
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0026 0.0035
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) glutaminase 2 0.0271 0.0593 0.3016
Brugia malayi hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0045 0.0227
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0051 0.032
Onchocerca volvulus 0.0023 0.0026 0.0116
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0223 0.0201
Trichomonas vaginalis glutaminase, putative 0.0271 0.0593 0.2556
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0051 0.032
Echinococcus granulosus cpg binding protein 0.0033 0.0049 0.0305
Trichomonas vaginalis esterase, putative 0.0109 0.0223 0.0887
Brugia malayi beta-lactamase family protein 0.0109 0.0223 0.1136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0105 0.1861
Schistosoma mansoni hypothetical protein 0.0101 0.0204 0.1284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0176
Loa Loa (eye worm) TK/INSR protein kinase 0.0265 0.058 0.2954
Echinococcus granulosus neuropeptide receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0026 0.0132
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0232 0.0503 0.0503
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0045 0.0887
Echinococcus multilocularis GPCR, family 2 0.0047 0.008 0.0109
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0082 0.0161 0.3208
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0113
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.008 0.0109
Schistosoma mansoni patched 1 0.0085 0.0167 0.1052
Leishmania major hypothetical protein, conserved 0.0082 0.0161 0.3208
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0051 0.0319
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0182 0.2408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0139 0.0706
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0082 0.0161 0.0221
Echinococcus granulosus geminin 0.0704 0.1584 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0051 0.0319
Schistosoma mansoni opsin-like receptor 0.0023 0.0026 0.0162
Echinococcus multilocularis serotonin receptor 0.0023 0.0026 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0204 0.1037
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0045 0.0421
Mycobacterium tuberculosis Probable aminotransferase 0.0154 0.0325 0.0303
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0026 0.0162
Chlamydia trachomatis SWIB complex protein 0.0232 0.0503 1
Schistosoma mansoni opsin-like receptor 0.0023 0.0026 0.0162
Mycobacterium ulcerans hypothetical protein 0.0024 0.0027 0.0004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0026 0.0162
Brugia malayi brahma associated protein 60 kDa 0.0232 0.0503 0.2562
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0139 0.0873
Entamoeba histolytica hypothetical protein 0.0076 0.0146 0.1285
Loa Loa (eye worm) hypothetical protein 0.0198 0.0426 0.2168
Brugia malayi hypothetical protein 0.0027 0.0035 0.0176
Brugia malayi Protein kinase domain containing protein 0.0265 0.058 0.2954
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0182 0.0702
Schistosoma mansoni tyrosine kinase 0.0265 0.058 0.3661
Loa Loa (eye worm) hypothetical protein 0.0083 0.0162 0.0827
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0139 0.019
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0026 0.0132
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0026 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0223 0.0887
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0426 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0082 0.0161 0.3208
Onchocerca volvulus 0.0125 0.0259 0.1158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0026 0.0162
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0082 0.0161 0.0221
Plasmodium vivax SET domain protein, putative 0.0125 0.0259 0.5154
Loa Loa (eye worm) brahma associated protein 0.0232 0.0503 0.2562
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0182 0.0928
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132
Mycobacterium ulcerans glutaminase 0.0271 0.0593 0.0571
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0026 0.0162
Echinococcus granulosus somatostatin receptor 0.0023 0.0026 0.0162
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0706
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Brugia malayi beta-lactamase family protein 0.0109 0.0223 0.1136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0139 0.0873
Schistosoma mansoni biogenic amine receptor 0.0023 0.0026 0.0162
Brugia malayi G-protein coupled receptor 0.0023 0.0026 0.0132
Onchocerca volvulus 0.0082 0.0161 0.072
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0026 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0139 0.0873
Leishmania major hypothetical protein, conserved 0.0027 0.0035 0.0182
Onchocerca volvulus 0.0023 0.0026 0.0116
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0107 0.0085
Loa Loa (eye worm) TK/KIN16 protein kinase 0.018 0.0386 0.1963
Echinococcus multilocularis neuroglian 0.0018 0.0014 0.0019
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.05
Schistosoma mansoni amine GPCR 0.0023 0.0026 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0139 0.0706
Onchocerca volvulus 0.0023 0.0026 0.0116
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0105 1
Onchocerca volvulus 0.0034 0.0051 0.0227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0311 0.1582
Echinococcus granulosus g protein coupled receptor 0.0023 0.0026 0.0162
Brugia malayi tailless protein 0.0034 0.0051 0.0259
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0027 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0051 0.0259
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0026 0.0132
Mycobacterium tuberculosis Conserved protein 0.0109 0.0223 0.0201
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0026 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.0688
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0132

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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