Detailed information for compound 1560795

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 442.576 | Formula: C26H26N4OS
  • H donors: 1 H acceptors: 2 LogP: 5.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1sc(nc1C)N1N=C2C(C1c1ccccc1)CCC/C/2=C/c1ccccc1
  • InChi: 1S/C26H26N4OS/c1-17-24(25(31)27-2)32-26(28-17)30-23(19-12-7-4-8-13-19)21-15-9-14-20(22(21)29-30)16-18-10-5-3-6-11-18/h3-8,10-13,16,21,23H,9,14-15H2,1-2H3,(H,27,31)/b20-16-
  • InChiKey: FCHAMQYISDHWJM-SILNSSARSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0187 0.2254 0.2251
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0129 0.1449 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0187 0.2254 0.3394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Echinococcus granulosus tubulin alpha chain 0.0378 0.4914 0.4912
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.1449 0.218
Loa Loa (eye worm) BEN-1 protein 0.0501 0.6636 1
Onchocerca volvulus 0.0035 0.0133 0.0151
Echinococcus granulosus g protein coupled receptor 0.0187 0.2254 0.2251
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0304 0.0945
Echinococcus granulosus neuropeptide Y receptor 0.0187 0.2254 0.2251
Leishmania major beta tubulin 0.0501 0.6636 1
Brugia malayi PAS domain containing protein 0.0047 0.0304 0.0458
Echinococcus multilocularis tubulin alpha 3 chain 0.0378 0.4914 0.4912
Schistosoma mansoni tubulin subunit beta 0.0501 0.6636 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0209 0.0315
Toxoplasma gondii beta-1 tubulin, putative 0.0501 0.6636 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0187 0.2254 0.3398
Leishmania major beta tubulin 0.0501 0.6636 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0187 0.2254 0.3394
Leishmania major cathepsin L-like protease 0.0062 0.0509 0.0761
Loa Loa (eye worm) neuropeptide F receptor 0.0187 0.2254 0.3398
Echinococcus granulosus Tubulin beta 2C chain 0.0501 0.6636 0.6634
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Schistosoma mansoni tubulin subunit alpha 0.0378 0.4914 0.7405
Schistosoma mansoni tubulin subunit alpha 0.0378 0.4914 0.7405
Brugia malayi GnHR receptor homolog 0.0187 0.2254 0.3398
Schistosoma mansoni alpha tubulin 0.0378 0.4914 0.7405
Onchocerca volvulus 0.0187 0.2254 1
Echinococcus multilocularis neuropeptide s receptor 0.0743 1 1
Trypanosoma brucei tubulin delta chain 0.0291 0.3704 0.558
Loa Loa (eye worm) tubulin alpha chain 0.0378 0.4914 0.7406
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1325 0.1997
Brugia malayi alpha-tubulin 0.0378 0.4914 0.7406
Giardia lamblia Alpha-tubulin 0.0378 0.4914 0.7405
Echinococcus granulosus single minded 2 0.0035 0.0133 0.0129
Plasmodium vivax tubulin epsilon chain, putative 0.0308 0.3938 0.5933
Mycobacterium leprae cell division protein FtsZ 0.0129 0.1449 0.5
Echinococcus multilocularis sex peptide receptor 0.0187 0.2254 0.2251
Echinococcus granulosus alpha tubulin 0.0378 0.4914 0.4912
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0187 0.2254 0.2251
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0509 0.0761
Echinococcus granulosus g protein coupled receptor 0.0187 0.2254 0.2251
Echinococcus granulosus peptide allatostatin:somatostatin 0.0187 0.2254 0.2251
Loa Loa (eye worm) G-protein coupled receptor 0.0187 0.2254 0.3398
Echinococcus granulosus tubulin epsilon chain 0.0308 0.3938 0.3936
Echinococcus multilocularis somatostatin receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis Tubulin beta 2C chain 0.0501 0.6636 0.6634
Echinococcus granulosus Tubulin alpha 1 chain 0.0378 0.4914 0.4912
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Schistosoma mansoni biogenic amine (5HT) receptor 0.0187 0.2254 0.3394
Echinococcus multilocularis tubulin alpha chain 0.0378 0.4914 0.4912
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0187 0.2254 0.3398
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.1449 0.218
Plasmodium falciparum tubulin delta chain, putative 0.0129 0.1449 0.218
Echinococcus granulosus 7TM GPCR rhodopsin 0.0187 0.2254 0.2251
Brugia malayi Melatonin receptor type 1A 0.0187 0.2254 0.3398
Leishmania major beta tubulin 0.0501 0.6636 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.082 0.123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Brugia malayi Tubulin beta chain 0.0129 0.1449 0.2184
Schistosoma mansoni tubulin subunit beta 0.0501 0.6636 1
Trypanosoma cruzi tubulin gamma chain 0.0308 0.3944 0.5941
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0187 0.2254 0.2251
Echinococcus multilocularis neuropeptide Y receptor 0.0187 0.2254 0.2251
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.2633 0.3968
Echinococcus multilocularis fmrfamide receptor 0.0187 0.2254 0.2251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Echinococcus granulosus tubulin alpha 1C chain 0.0378 0.4914 0.4912
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Echinococcus granulosus neuropeptide receptor A26 0.0743 1 1
Trypanosoma brucei beta tubulin 0.0501 0.6636 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0187 0.2254 0.2251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0223 0.276 0.2757
Leishmania major gamma-tubulin 0.0308 0.3944 0.5941
Schistosoma mansoni opsin-like receptor 0.0187 0.2254 0.3394
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0304 0.0453
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0155 0.1809 0.2722
Loa Loa (eye worm) hypothetical protein 0.0225 0.2785 0.4198
Echinococcus granulosus somatostatin receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis snurportin 1 0.0372 0.4829 0.4827
Toxoplasma gondii beta tubulin 0.0501 0.6636 1
Loa Loa (eye worm) tubulin alpha chain 0.0378 0.4914 0.7406
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0178 0.0268
Trypanosoma brucei beta tubulin 0.0282 0.3578 0.539
Onchocerca volvulus 0.0187 0.2254 1
Schistosoma mansoni biogenic amine receptor 0.0187 0.2254 0.3394
Brugia malayi putative neuropeptide receptor NPR1 0.0187 0.2254 0.3398
Toxoplasma gondii alpha-tubulin I, putative 0.0378 0.4914 0.7405
Plasmodium vivax tubulin gamma chain, putative 0.0308 0.3944 0.5941
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0133 0.02
Echinococcus multilocularis tubulin alpha chain 0.0378 0.4914 0.4912
Schistosoma mansoni amine GPCR 0.0187 0.2254 0.3394
Onchocerca volvulus 0.0187 0.2254 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus granulosus snurportin 1 0.0372 0.4829 0.4827
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0187 0.2254 0.3394
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0354 0.0528
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0187 0.2254 0.3394
Brugia malayi RE15519p 0.0187 0.2254 0.3398
Loa Loa (eye worm) tubulin beta-4 chain 0.0501 0.6636 1
Echinococcus granulosus g-protein coupled receptor 0.0187 0.2254 0.2251
Schistosoma mansoni amine GPCR 0.0187 0.2254 0.3394
Trichomonas vaginalis tubulin gamma chain, putative 0.0501 0.6636 1
Trichomonas vaginalis tubulin beta chain, putative 0.0378 0.4914 0.7405
Brugia malayi chromobox protein homolog 3 0.0047 0.0304 0.0458
Schistosoma mansoni hypothetical protein 0.0187 0.2254 0.3394
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0178 0.0174
Schistosoma mansoni tubulin subunit beta 0.0501 0.6636 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0501 0.6636 0.6634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1325 0.1997
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0187 0.2254 0.2251
Schistosoma mansoni alpha tubulin 0.0378 0.4914 0.7405
Onchocerca volvulus Neuropeptide F receptor homolog 0.0187 0.2254 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0187 0.2254 0.3394
Echinococcus multilocularis tubulin alpha chain 0.0378 0.4914 0.4912
Echinococcus multilocularis fmrfamide receptor 0.0187 0.2254 0.2251
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0378 0.4914 0.7405
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Echinococcus granulosus g protein coupled receptor 0.0187 0.2254 0.2251
Schistosoma mansoni tubulin subunit beta 0.0501 0.6636 1
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Schistosoma mansoni growth hormone secretagogue receptor 0.0187 0.2254 0.3394
Giardia lamblia Epsilon tubulin 0.0155 0.1809 0.2722
Entamoeba histolytica tubulin gamma chain 0.0308 0.3944 0.5941
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0112 0.0163
Giardia lamblia Gamma tubulin 0.0308 0.3944 0.5941
Schistosoma mansoni neuropeptide receptor 0.0187 0.2254 0.3394
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2551 0.3841
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Onchocerca volvulus 0.0037 0.0162 0.0285
Loa Loa (eye worm) hypothetical protein 0.0032 0.0092 0.0139
Entamoeba histolytica tubulin family protein 0.0501 0.6636 1
Trypanosoma cruzi zeta tubulin, putative 0.04 0.5219 0.7864
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Loa Loa (eye worm) tubulin alpha-3 chain 0.0225 0.2785 0.4198
Leishmania major beta tubulin 0.0501 0.6636 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0129 0.1449 0.218
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0129 0.1449 0.218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Plasmodium falciparum alpha tubulin 1 0.0378 0.4914 0.7405
Schistosoma mansoni neuropeptide receptor 0.0187 0.2254 0.3394
Echinococcus multilocularis chromobox protein 1 0.0084 0.082 0.0816
Loa Loa (eye worm) tubulin beta-2A chain 0.0501 0.6636 1
Echinococcus granulosus Tubulin beta 2C chain 0.0501 0.6636 0.6634
Trypanosoma brucei alpha tubulin 0.0378 0.4914 0.7405
Echinococcus multilocularis tubulin alpha 1C chain 0.0378 0.4914 0.4912
Echinococcus granulosus tubulin alpha 1C chain 0.0378 0.4914 0.4912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Brugia malayi Serotonin receptor 0.0187 0.2254 0.3398
Echinococcus granulosus Tubulin beta 2C chain 0.0501 0.6636 0.6634
Trypanosoma brucei zeta tubulin, putative 0.04 0.5219 0.7864
Brugia malayi Cell division protein ftsZ 0.0129 0.1449 0.2184
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis Tubulin beta 2C chain 0.0501 0.6636 0.6634
Plasmodium vivax delta tubulin, putative 0.0129 0.1449 0.218
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0282 0.3578 0.539
Plasmodium vivax tubulin beta chain, putative 0.0501 0.6636 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0304 0.0453
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0509 0.0761
Echinococcus granulosus geminin 0.0205 0.2499 0.2497
Echinococcus multilocularis tubulin subunit TubB 0.0378 0.4914 0.4912
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0249 0.3112 0.4689
Echinococcus granulosus 7tm_1 domain containing protein 0.0187 0.2254 0.2251
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0187 0.2254 0.3398
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Schistosoma mansoni neuropeptide F-like receptor 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0158 0.1852 0.2791
Echinococcus granulosus GPCR family 2 0.0038 0.0178 0.0174
Echinococcus granulosus biogenic amine 5HT receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis musashi 0.0033 0.0101 0.0097
Trypanosoma cruzi tubulin delta chain 0.0291 0.3704 0.558
Giardia lamblia Delta tubulin 0.0129 0.1449 0.218
Loa Loa (eye worm) hypothetical protein 0.0035 0.0132 0.0199
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Trichomonas vaginalis tubulin gamma chain, putative 0.0129 0.1449 0.218
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis tubulin alpha chain 0.0378 0.4914 0.4912
Echinococcus multilocularis allatostatin A receptor 0.0187 0.2254 0.2251
Leishmania major beta tubulin 0.0501 0.6636 1
Plasmodium vivax tubulin alpha chain, putative 0.0378 0.4914 0.7405
Echinococcus granulosus chromobox protein 1 0.0084 0.082 0.0816
Giardia lamblia Alpha-tubulin 0.0378 0.4914 0.7405
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trichomonas vaginalis tubulin epsilon chain, putative 0.0378 0.4914 0.7405
Echinococcus multilocularis Tubulin alpha 1 chain 0.0378 0.4914 0.4912
Echinococcus multilocularis tubulin gamma 1 chain 0.0308 0.3944 0.3941
Trichomonas vaginalis rotamase, putative 0.004 0.0209 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Mycobacterium tuberculosis Cell division protein FtsZ 0.0129 0.1449 0.5
Brugia malayi Serotonin receptor 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Onchocerca volvulus 0.0187 0.2254 1
Onchocerca volvulus 0.0187 0.2254 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0133 0.0129
Echinococcus granulosus neuropeptide Y receptor 0.0187 0.2254 0.2251
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis tubulin delta chain 0.0129 0.1449 0.1446
Giardia lamblia Beta tubulin 0.0501 0.6636 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0501 0.6636 0.6634
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Plasmodium falciparum importin beta, putative 0.0035 0.0132 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Trypanosoma brucei beta tubulin 0.0501 0.6636 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis geminin 0.0205 0.2499 0.2497
Brugia malayi Tubulin beta chain 0.0153 0.1776 0.2676
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.004 0.0055
Trichomonas vaginalis tubulin, putative 0.0501 0.6636 1
Toxoplasma gondii tubulin, putative 0.0026 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus granulosus expressed protein 0.004 0.0209 0.0205
Loa Loa (eye worm) tubulin beta chain 0.0501 0.6636 1
Onchocerca volvulus 0.0187 0.2254 1
Trichomonas vaginalis rotamase, putative 0.0039 0.0196 0.0289
Echinococcus granulosus alpha 1A adrenergic receptor 0.0187 0.2254 0.2251
Schistosoma mansoni neuropeptide receptor 0.0187 0.2254 0.3394
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Mycobacterium ulcerans cell division protein FtsZ 0.0129 0.1449 1
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0794 0.1197
Trichomonas vaginalis tubulin epsilon chain, putative 0.0501 0.6636 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Schistosoma mansoni importin beta-1 0.0035 0.0132 0.0193
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0132 0.0193
Echinococcus granulosus tubulin alpha chain 0.0378 0.4914 0.4912
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0187 0.2254 0.2251
Echinococcus granulosus tachykinin peptides receptor 99D 0.0187 0.2254 0.2251
Echinococcus granulosus tubulin alpha 3 chain 0.0378 0.4914 0.4912
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Echinococcus multilocularis beta tubulin 0.0501 0.6636 0.6634
Echinococcus multilocularis orexin receptor type 2 0.0187 0.2254 0.2251
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0196 0.0289
Onchocerca volvulus 0.0187 0.2254 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0187 0.2254 0.3394
Brugia malayi intermediate filament protein 0.0033 0.0101 0.0152
Brugia malayi G protein-coupled receptor 0.0187 0.2254 0.3398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Echinococcus multilocularis hypothetical protein 0.0378 0.4914 0.4912
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0187 0.2254 0.3398
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis expressed protein 0.004 0.0209 0.0205
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trypanosoma brucei zeta tubulin 0.04 0.5219 0.7864
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0112 0.0163
Echinococcus multilocularis lamin 0.0033 0.0101 0.0097
Echinococcus multilocularis g-protein coupled receptor 0.0187 0.2254 0.2251
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Brugia malayi Tubulin alpha-2 chain 0.0378 0.4914 0.7406
Schistosoma mansoni hypothetical protein 0.0038 0.0178 0.0262
Trichomonas vaginalis chromobox protein, putative 0.0084 0.082 0.123
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Leishmania major beta tubulin 0.0501 0.6636 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0101 0.0152
Schistosoma mansoni hypothetical protein 0.0187 0.2254 0.3394
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0187 0.2254 0.3394
Echinococcus multilocularis neuropeptides capa receptor 0.0187 0.2254 0.2251
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0378 0.4914 0.7406
Echinococcus granulosus hypothetical protein 0.0187 0.2254 0.2251
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0178 0.0174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Loa Loa (eye worm) G-protein coupled receptor 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Leishmania major importin beta-1 subunit, putative 0.0028 0.004 0.0055
Schistosoma mansoni hypothetical protein 0.0205 0.2499 0.3763
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0187 0.2254 0.3394
Echinococcus granulosus lamin 0.0033 0.0101 0.0097
Leishmania major beta tubulin 0.0501 0.6636 1
Onchocerca volvulus 0.0187 0.2254 1
Echinococcus granulosus tubulin beta 1 chain 0.0501 0.6636 0.6634
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0187 0.2254 0.2251
Schistosoma mansoni hypothetical protein 0.0187 0.2254 0.3394
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0187 0.2254 0.3398
Echinococcus granulosus fmrfamide receptor 0.0187 0.2254 0.2251
Loa Loa (eye worm) hypothetical protein 0.0148 0.1709 0.2576
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trichomonas vaginalis tubulin beta chain, putative 0.0378 0.4914 0.7405
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Trypanosoma brucei beta tubulin 0.0501 0.6636 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0132 0.0193
Echinococcus multilocularis g protein coupled receptor 0.0187 0.2254 0.2251
Schistosoma mansoni lamin 0.0033 0.0101 0.0146
Trypanosoma brucei epsilon tubulin 0.0282 0.3578 0.539
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0187 0.2254 0.2251
Leishmania major cathepsin L-like protease 0.0062 0.0509 0.0761
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis neuropeptides capa receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis g protein coupled receptor 0.0187 0.2254 0.2251
Brugia malayi sulfakinin receptor protein 0.0187 0.2254 0.3398
Onchocerca volvulus 0.0187 0.2254 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Plasmodium vivax tubulin alpha chain, putative 0.0378 0.4914 0.7405
Echinococcus granulosus tubulin alpha chain 0.0378 0.4914 0.4912
Echinococcus multilocularis tubulin alpha 0.0282 0.3578 0.3576
Leishmania major beta tubulin 0.0501 0.6636 1
Trichomonas vaginalis tubulin beta chain, putative 0.0378 0.4914 0.7405
Echinococcus multilocularis tubulin subunit beta 0.0501 0.6636 0.6634
Loa Loa (eye worm) tubulin beta chain 0.0129 0.1449 0.2184
Schistosoma mansoni chromobox protein 0.0084 0.082 0.123
Schistosoma mansoni hypothetical protein 0.0038 0.0178 0.0262
Loa Loa (eye worm) TYRA-2 protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0306 0.3907 0.5888
Leishmania major epsilon tubulin, putative 0.0308 0.3938 0.5933
Giardia lamblia Beta tubulin 0.0501 0.6636 1
Echinococcus granulosus tubulin delta chain 0.0129 0.1449 0.1446
Trichomonas vaginalis tubulin beta chain, putative 0.0153 0.1776 0.2672
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Echinococcus granulosus tubulin alpha chain 0.0378 0.4914 0.4912
Schistosoma mansoni rotamase 0.004 0.0209 0.0309
Schistosoma mansoni amine GPCR 0.0187 0.2254 0.3394
Schistosoma mansoni chromobox protein 0.0084 0.082 0.123
Brugia malayi G protein-coupled receptor F59B2.13 0.0187 0.2254 0.3398
Leishmania major beta tubulin 0.0501 0.6636 1
Schistosoma mansoni opsin-like receptor 0.0187 0.2254 0.3394
Echinococcus multilocularis Tubulin alpha 1 chain 0.0378 0.4914 0.4912
Onchocerca volvulus 0.0187 0.2254 1
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus granulosus chromobox protein 1 0.0084 0.082 0.0816
Schistosoma mansoni biogenic amine receptor 0.0187 0.2254 0.3394
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0196 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0509 0.0761
Echinococcus granulosus biogenic amine 5HT receptor 0.0187 0.2254 0.2251
Brugia malayi Dopamine receptor 0.0187 0.2254 0.3398
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0434 0.0648
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0223 0.276 0.2757
Trichomonas vaginalis tubulin gamma chain, putative 0.0308 0.3938 0.5933
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) tubulin beta-1 chain 0.0501 0.6636 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0378 0.4914 0.4912
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trichomonas vaginalis tubulin, putative 0.0153 0.1776 0.2672
Echinococcus granulosus intermediate filament protein 0.0033 0.0101 0.0097
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Trypanosoma brucei alpha tubulin 0.0378 0.4914 0.7405
Echinococcus multilocularis neuropeptide FF receptor 2 0.0187 0.2254 0.2251
Echinococcus multilocularis neuropeptide receptor 0.0187 0.2254 0.2251
Leishmania major beta tubulin 0.0501 0.6636 1
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0178 0.0268
Loa Loa (eye worm) neuropeptide F receptor 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0249 0.3112 0.4689
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0132 0.0193
Brugia malayi hypothetical protein 0.0158 0.1852 0.2791
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus granulosus neuropeptides capa receptor 0.0187 0.2254 0.2251
Loa Loa (eye worm) BEN-1 protein 0.0501 0.6636 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1776 0.2672
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Brugia malayi Importin beta-1 subunit 0.0035 0.0132 0.0199
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0187 0.2254 0.2251
Schistosoma mansoni histamine h1 receptor 0.0187 0.2254 0.3394
Brugia malayi Dopamine receptor protein 2 0.0187 0.2254 0.3398
Onchocerca volvulus 0.0187 0.2254 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0187 0.2254 0.2251
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Brugia malayi AKH receptor 0.0187 0.2254 0.3398
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Echinococcus granulosus lamin dm0 0.0033 0.0101 0.0097
Brugia malayi Dopamine receptor protein 1 0.0187 0.2254 0.3398
Leishmania major beta tubulin 0.0501 0.6636 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0282 0.3578 0.539
Schistosoma mansoni tubulin subunit epsilon 0.0308 0.3938 0.5933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Brugia malayi RNA, U transporter 1 0.0099 0.1027 0.1548
Schistosoma mansoni tubulin subunit alpha 0.0378 0.4914 0.7405
Brugia malayi beta-tubulin, identical 0.0501 0.6636 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0378 0.4914 0.4912
Echinococcus multilocularis tubulin alpha chain 0.0378 0.4914 0.4912
Echinococcus multilocularis Tubulin beta 2C chain 0.0501 0.6636 0.6634
Schistosoma mansoni amine GPCR 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Brugia malayi neuropeptide F receptor 0.0187 0.2254 0.3398
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0187 0.2254 0.2251
Onchocerca volvulus 0.0153 0.1776 0.7777
Trichomonas vaginalis tubulin alpha chain, putative 0.0501 0.6636 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.082 0.0816
Trichomonas vaginalis tubulin epsilon chain, putative 0.0378 0.4914 0.7405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Echinococcus granulosus Tubulin beta 2C chain 0.0501 0.6636 0.6634
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0187 0.2254 0.2251
Leishmania major delta tubulin, putative 0.0291 0.3704 0.558
Echinococcus multilocularis lamin dm0 0.0033 0.0101 0.0097
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0187 0.2254 0.3398
Schistosoma mansoni tubulin subunit alpha 0.0129 0.1449 0.218
Echinococcus multilocularis GPCR, family 2 0.0038 0.0178 0.0174
Loa Loa (eye worm) beta-tubulin 0.0501 0.6636 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0196 0.0289
Schistosoma mansoni opsin-like receptor 0.0187 0.2254 0.3394
Trypanosoma brucei alpha tubulin 0.0378 0.4914 0.7405
Echinococcus multilocularis neuropeptide receptor 0.0187 0.2254 0.2251
Brugia malayi Tubulin gamma chain 0.0308 0.3944 0.5943
Brugia malayi Tubulin beta-1 chain 0.0501 0.6636 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.082 0.1235
Echinococcus granulosus neuropeptide FF receptor 2 0.0187 0.2254 0.2251
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0304 0.0452
Echinococcus granulosus tubulin alpha chain 0.0378 0.4914 0.4912
Schistosoma mansoni hypothetical protein 0.0372 0.4829 0.7276
Leishmania major beta tubulin 0.0501 0.6636 1
Echinococcus granulosus tm gpcr rhodopsin 0.0187 0.2254 0.2251
Brugia malayi tubulin alpha chain - mouse 0.0378 0.4914 0.7406
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0196 0.0289
Trypanosoma brucei beta tubulin 0.0501 0.6636 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4829 0.7278
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0209 0.0315
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0354 0.0528
Onchocerca volvulus 0.0187 0.2254 1
Loa Loa (eye worm) tubulin alpha 2 0.0249 0.3112 0.4689
Brugia malayi Tubulin alpha chain 0.0129 0.1449 0.2184
Echinococcus multilocularis Tubulin alpha 1 chain 0.0378 0.4914 0.4912
Echinococcus multilocularis Tubulin beta 2C chain 0.0501 0.6636 0.6634
Brugia malayi Tachykinin-like peptides receptor 99D 0.0187 0.2254 0.3398
Brugia malayi Tubulin alpha chain 0.0378 0.4914 0.7406
Loa Loa (eye worm) hypothetical protein 0.0082 0.0794 0.1197
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0004 0.0006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.041 0.5362 0.8081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Plasmodium falciparum tubulin epsilon chain, putative 0.0308 0.3938 0.5933
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0209 0.0309
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Brugia malayi follicle stimulating hormone receptor 0.041 0.5362 0.8081
Trypanosoma brucei tubulin gamma chain 0.0308 0.3944 0.5941
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0187 0.2254 0.3398
Trypanosoma cruzi beta tubulin, putative 0.0501 0.6636 1
Schistosoma mansoni biogenic amine receptor 0.0187 0.2254 0.3394
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0178 0.0268
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0187 0.2254 0.3394
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0187 0.2254 0.2251
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Trypanosoma brucei alpha tubulin, putative 0.0153 0.1776 0.2672
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis serotonin receptor 0.0187 0.2254 0.2251
Trypanosoma brucei epsilon tubulin 0.0308 0.3938 0.5933
Echinococcus multilocularis neuropeptide receptor A26 0.0743 1 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trichomonas vaginalis tubulin gamma chain, putative 0.0308 0.3944 0.5941
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Entamoeba histolytica tubulin alpha-1 chain 0.0378 0.4914 0.7405
Brugia malayi putative neuropeptide receptor 0.0187 0.2254 0.3398
Loa Loa (eye worm) tubulin gamma chain 0.0308 0.3944 0.5943
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.3907 0.5888
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Schistosoma mansoni intermediate filament proteins 0.0033 0.0101 0.0146
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0187 0.2254 0.3394
Schistosoma mansoni tubulin subunit beta 0.0129 0.1449 0.218
Trichomonas vaginalis tubulin, putative 0.0155 0.1814 0.273
Onchocerca volvulus 0.0187 0.2254 1
Brugia malayi neuropeptide F receptor 0.0187 0.2254 0.3398
Echinococcus multilocularis g protein coupled receptor 0.0187 0.2254 0.2251
Echinococcus granulosus tubulin gamma 1 chain 0.0308 0.3944 0.3941
Schistosoma mansoni tubulin subunit gamma 0.0308 0.3944 0.5941
Echinococcus granulosus tm gpcr rhodopsin 0.0187 0.2254 0.2251
Schistosoma mansoni hypothetical protein 0.0205 0.2499 0.3763
Echinococcus granulosus orexin receptor type 2 0.0187 0.2254 0.2251
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.004 0.0055
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trichomonas vaginalis tubulin, putative 0.0153 0.1776 0.2672
Trypanosoma cruzi epsilon tubulin, putative 0.0308 0.3938 0.5933
Echinococcus granulosus tubulin alpha 0.0282 0.3578 0.3576
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0132 0.0128
Echinococcus granulosus serotonin receptor 0.0187 0.2254 0.2251
Loa Loa (eye worm) hypothetical protein 0.0148 0.1709 0.2576
Echinococcus granulosus neuropeptide receptor 0.0187 0.2254 0.2251
Echinococcus multilocularis serotonin receptor 0.0187 0.2254 0.2251
Brugia malayi larval opioid receptor 0.0187 0.2254 0.3398
Echinococcus multilocularis tubulin alpha 3 chain 0.0378 0.4914 0.4912
Schistosoma mansoni adenoreceptor 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0132 0.0193
Leishmania major beta tubulin 0.0501 0.6636 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0291 0.3704 0.558
Trypanosoma cruzi zeta tubulin, putative 0.04 0.5219 0.7864
Entamoeba histolytica tubulin alpha chain, putative 0.0378 0.4914 0.7405
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0187 0.2254 0.2251
Trypanosoma cruzi epsilon tubulin, putative 0.0308 0.3938 0.5933
Onchocerca volvulus 0.0187 0.2254 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0187 0.2254 0.3394
Schistosoma mansoni hypothetical protein 0.0082 0.0794 0.1192
Brugia malayi Heterochromatin protein 1 0.0084 0.082 0.1235
Loa Loa (eye worm) alpha-tubulin 0.0378 0.4914 0.7406
Schistosoma mansoni myosin xvIII 0.0187 0.2254 0.3394
Echinococcus multilocularis dro:myosuppressin receptor 0.0187 0.2254 0.2251
Trypanosoma cruzi tubulin delta chain 0.0291 0.3704 0.558
Echinococcus multilocularis beta tubulin 0.0501 0.6636 0.6634
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0214 0.2633 0.3968
Toxoplasma gondii beta-tubulin, putative 0.0501 0.6636 1
Echinococcus granulosus tubulin subunit TubB 0.0378 0.4914 0.4912
Treponema pallidum cell division protein FtsZ 0.0129 0.1449 0.5
Schistosoma mansoni amine GPCR 0.0187 0.2254 0.3394
Leishmania major cathepsin L-like protease 0.0062 0.0509 0.0761
Plasmodium falciparum tubulin gamma chain 0.0308 0.3944 0.5941
Giardia lamblia Beta tubulin 0.0501 0.6636 1
Echinococcus granulosus allatostatin A receptor 0.0187 0.2254 0.2251
Trichomonas vaginalis tubulin beta chain, putative 0.0378 0.4914 0.7405
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0187 0.2254 0.2251
Echinococcus granulosus neuropeptide receptor 0.0187 0.2254 0.2251
Loa Loa (eye worm) melatonin receptor type 1A 0.0187 0.2254 0.3398
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0187 0.2254 0.3394
Echinococcus granulosus beta tubulin 0.0501 0.6636 0.6634
Loa Loa (eye worm) tubulin alpha 2 0.0249 0.3112 0.4689
Trypanosoma cruzi alpha tubulin, putative 0.0378 0.4914 0.7405
Brugia malayi ORL1-like opioid receptor 0.0187 0.2254 0.3398
Onchocerca volvulus 0.0187 0.2254 1
Leishmania major beta tubulin 0.0501 0.6636 1
Echinococcus granulosus tubulin subunit beta 0.0501 0.6636 0.6634
Entamoeba histolytica tubulin family protein 0.0501 0.6636 1
Echinococcus granulosus sex peptide receptor 0.0187 0.2254 0.2251
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Schistosoma mansoni neuropeptide receptor 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0047 0.0304 0.0458
Trichomonas vaginalis tubulin epsilon chain, putative 0.0501 0.6636 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0153 0.1776 0.2672
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Brugia malayi hypoxia-induced factor 1 0.0146 0.1681 0.2533
Toxoplasma gondii alpha tubulin TUBA1 0.0378 0.4914 0.7405
Onchocerca volvulus Huntingtin homolog 0.0148 0.1709 0.7469
Echinococcus granulosus G protein coupled receptor 139 0.0187 0.2254 0.2251
Trypanosoma brucei epsilon tubulin 0.0308 0.3938 0.5933
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) hypothetical protein 0.0037 0.0162 0.0244
Schistosoma mansoni biogenic amine (5HT) receptor 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0152
Echinococcus granulosus tubulin beta 4A class IVa 0.0501 0.6636 0.6634
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0509 0.0761
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0187 0.2254 0.3398
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Echinococcus granulosus dro:myosuppressin receptor 0.0187 0.2254 0.2251
Leishmania major beta tubulin 0.0501 0.6636 1
Leishmania major zeta tubulin, putative 0.04 0.5219 0.7864
Brugia malayi hypothetical protein 0.0148 0.1709 0.2576
Onchocerca volvulus 0.0187 0.2254 1
Trichomonas vaginalis tubulin beta chain, putative 0.0501 0.6636 1
Schistosoma mansoni neuropeptide F-like receptor 0.0187 0.2254 0.3394
Echinococcus granulosus importin subunit beta 1 0.0035 0.0132 0.0128
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0249 0.3112 0.4686
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0187 0.2254 0.2251
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Schistosoma mansoni tubulin subunit beta 0.0501 0.6636 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0196 0.0289
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0178 0.0268
Plasmodium falciparum tubulin beta chain 0.0501 0.6636 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1776 0.2672
Schistosoma mansoni alpha tubulin 0.0378 0.4914 0.7405
Echinococcus multilocularis neuropeptide Y receptor 0.0187 0.2254 0.2251
Echinococcus granulosus Tubulin beta 2C chain 0.0501 0.6636 0.6634
Loa Loa (eye worm) tubulin alpha-2 chain 0.0378 0.4914 0.7406
Trichomonas vaginalis importin beta-1, putative 0.0028 0.004 0.0055
Echinococcus multilocularis tubulin epsilon chain 0.0308 0.3938 0.3936
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0324 0.0483
Schistosoma mansoni hypothetical protein 0.0038 0.0178 0.0262
Onchocerca volvulus 0.0187 0.2254 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.004 0.0055
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Leishmania major beta tubulin 0.0501 0.6636 1
Brugia malayi hypothetical protein 0.0187 0.2254 0.3398
Leishmania major beta tubulin 0.0501 0.6636 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0101 0.0152
Loa Loa (eye worm) alpha-tubulin 0.0378 0.4914 0.7406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0187 0.2254 0.2251
Trichomonas vaginalis tubulin beta chain, putative 0.0378 0.4914 0.7405
Schistosoma mansoni hypothetical protein 0.0038 0.0178 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0509 0.0761
Schistosoma mansoni lamin 0.0033 0.0101 0.0146
Schistosoma mansoni hypothetical protein 0.0187 0.2254 0.3394
Trypanosoma brucei alpha tubulin 0.0378 0.4914 0.7405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.2254 0.2251
Schistosoma mansoni tubulin subunit delta 0.0129 0.1449 0.218
Echinococcus granulosus beta tubulin 0.0501 0.6636 0.6634
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0354 0.1177
Echinococcus granulosus tubulin alpha 3 chain 0.0378 0.4914 0.4912
Leishmania major beta tubulin 0.0501 0.6636 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis tubulin beta 1 chain 0.0501 0.6636 0.6634
Brugia malayi tubulin alpha-2 chain 0.0378 0.4914 0.7406
Brugia malayi G-protein coupled receptor 0.0187 0.2254 0.3398
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0187 0.2254 1
Leishmania major alpha tubulin 0.0378 0.4914 0.7405
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Trichomonas vaginalis tubulin beta chain, putative 0.0378 0.4914 0.7405
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0187 0.2254 0.2251
Entamoeba histolytica hypothetical protein 0.0028 0.004 0.0055
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1776 0.2672
Onchocerca volvulus Huntingtin homolog 0.0148 0.1709 0.7469
Loa Loa (eye worm) tubulin alpha 2 0.0096 0.0983 0.1481
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1681 0.2533
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0225 0.2785 0.4194
Echinococcus granulosus Tubulin alpha 1 chain 0.0378 0.4914 0.4912
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0196 0.0289
Brugia malayi G-protein coupled receptor 0.0187 0.2254 0.3398
Schistosoma mansoni tubulin subunit beta 0.0501 0.6636 1
Echinococcus multilocularis G protein coupled receptor 139 0.0187 0.2254 0.2251
Plasmodium falciparum alpha tubulin 2 0.0378 0.4914 0.7405
Brugia malayi Tubulin alpha-2 chain 0.0378 0.4914 0.7406
Echinococcus granulosus neuropeptides capa receptor 0.0187 0.2254 0.2251
Echinococcus granulosus peroxisome assembly protein 26 0.0378 0.4914 0.4912
Schistosoma mansoni neuropeptide f receptor 76f 0.0187 0.2254 0.3394
Schistosoma mansoni single-minded 0.0047 0.0304 0.0452
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0101 0.0152
Echinococcus granulosus Tubulin alpha 1 chain 0.0378 0.4914 0.4912
Echinococcus multilocularis G-protein coupled receptor, putative 0.0187 0.2254 0.2251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.2254 0.3394
Loa Loa (eye worm) hypothetical protein 0.0187 0.2254 0.3398

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4921 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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