Detailed information for compound 1561910

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.396 | Formula: C21H20N2O
  • H donors: 0 H acceptors: 2 LogP: 3.71 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCc2c1ccc(n2)C#Cc1ccccc1)C1CCCC1
  • InChi: 1S/C21H20N2O/c24-21-19-13-12-17(11-10-16-6-2-1-3-7-16)22-20(19)14-15-23(21)18-8-4-5-9-18/h1-3,6-7,12-13,18H,4-5,8-9,14-15H2
  • InChiKey: ZDQYIJNPNXCKRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, metabotropic 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ABC transporter, putative 0.0015 0.006 0.0301
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Plasmodium vivax ABC transporter B family member 3, putative 0.0015 0.006 0.0244
Brugia malayi hypothetical protein 0.0015 0.006 0.0056
Entamoeba histolytica P-glycoprotein-1 0.0015 0.006 0.115
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0058 0.0288
Schistosoma mansoni multidrug resistance protein 0.0066 0.0522 0.0605
Leishmania major cathepsin L-like protease 0.0015 0.0058 0.0615
Echinococcus multilocularis multidrug resistance associated protein 7 0.0066 0.0522 0.0601
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.006 0.0065
Onchocerca volvulus 0.001 0.001 0.0032
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0018 0.0086 0.0524
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0075 0.0297
Brugia malayi hypothetical protein 0.003 0.0195 0.0191
Schistosoma mansoni lamin 0.0024 0.0141 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0195 0.1026
Leishmania major elongation factor 1-gamma, putative 0.0083 0.0669 1
Echinococcus granulosus geminin 0.0153 0.131 0.1515
Toxoplasma gondii co-chaperone GrpE protein 0.0028 0.0176 0.2633
Trypanosoma cruzi co-chaperone GrpE, putative 0.0028 0.0176 0.2598
Schistosoma mansoni elongation factor 1-gamma 0.0083 0.0669 0.0776
Echinococcus granulosus glutathione S transferase 0.0207 0.1797 0.208
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.096 0.8623 1
Echinococcus multilocularis regulator of G protein signaling 7 0.003 0.0195 0.0221
Mycobacterium ulcerans GrpE protein (Hsp-70 cofactor) 0.0028 0.0176 0.2378
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0009 0.0003 0.0013
Onchocerca volvulus 0.001 0.0012 0.0044
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0015 0.006 0.007
Echinococcus multilocularis multidrug resistance associated protein 4 0.0051 0.0382 0.0439
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.007
Trichomonas vaginalis DNA helicase recq1, putative 0.0018 0.0083 0.0424
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.0057
Echinococcus multilocularis glutathione s transferase mu 0.0328 0.2897 0.3356
Trypanosoma brucei elongation factor 1 gamma, putative 0.0083 0.0669 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.003 0.0195 0.0191
Entamoeba histolytica ATP-binding cassette protein, putative 0.0066 0.0522 1
Loa Loa (eye worm) ABC transporter 0.0015 0.006 0.0057
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0058 0.0054
Entamoeba histolytica recQ family helicase, putative 0.0018 0.0083 0.1587
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.006 0.0065
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.006 0.0065
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.006 0.0065
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.006 0.0065
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0073 0.0586 0.8743
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0027 0.0165 0.0187
Plasmodium vivax vivapain-2 0.0015 0.0058 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0012 0.0044
Echinococcus granulosus axis inhibition protein axin 0.003 0.0195 0.0221
Entamoeba histolytica hypothetical protein 0.0033 0.0215 0.4125
Plasmodium falciparum multidrug resistance-associated protein 1 0.0015 0.006 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0275
Giardia lamblia Multidrug resistance-associated protein 1 0.0066 0.0517 0.9906
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0195 0.1026
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.006 0.0301
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0083 0.0091
Trichomonas vaginalis ABC transporter, putative 0.0015 0.006 0.0301
Schistosoma mansoni hypothetical protein 0.096 0.8623 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0083 0.1238
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0012 0.0234
Brugia malayi Cathepsin L-like precursor 0.001 0.0012 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0165 0.0191
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0033 0.0224 0.0255
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0015 0.006 0.0301
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0033 0.0224 0.3161
Leishmania major elongation factor-1 gamma 0.0083 0.0669 1
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0083 0.0669 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0075 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0066 0.0522 0.0519
Brugia malayi multidrug resistance related protein 1 0.0066 0.0522 0.0518
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0003 0.0004
Leishmania major cathepsin L-like protease 0.0058 0.0444 0.6534
Schistosoma mansoni multidrug resistance protein 0.0015 0.0055 0.0064
Echinococcus multilocularis musashi 0.0024 0.0141 0.0159
Plasmodium vivax ABC transporter B family member 6, putative 0.0015 0.006 0.0244
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0015 0.006 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Plasmodium vivax multidrug resistance protein 2, putative 0.0015 0.006 0.0244
Plasmodium vivax elongation factor 1-gamma, putative 0.0083 0.0669 0.2719
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0039 0.027 0.4032
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.007
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0033 0.0224 0.0255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0195 0.1026
Entamoeba histolytica P-glycoprotein 6, putative 0.0015 0.006 0.115
Brugia malayi ABC transporter family protein 0.0015 0.006 0.0056
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0058 0.1104
Echinococcus multilocularis cysteine protease 0.0015 0.0058 0.0062
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0039 0.0035
Brugia malayi ABC transporter family protein 0.0015 0.006 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0073 0.0586 0.8743
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.003 0.0195 0.0192
Giardia lamblia Multidrug resistance-associated protein 1 0.0066 0.0522 1
Echinococcus granulosus Regulator of G protein signaling 20 0.003 0.0195 0.0221
Brugia malayi hypothetical protein 0.003 0.0195 0.0191
Brugia malayi Cathepsin L-like cysteine proteinase 0.001 0.0012 0.0008
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.003 0.0195 0.1026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0083 0.008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.0224 0.1181
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.006 0.0065
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0033 0.0224 0.0255
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0075 0.4124
Plasmodium vivax glutathione S-transferase, putative 0.028 0.2462 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0015 0.0055 0.1056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Brugia malayi PXA domain containing protein 0.003 0.0195 0.0191
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0015 0.006 0.0244
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0015 0.006 0.0651
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0215 0.0245
Echinococcus granulosus multidrug resistance associated protein 7 0.0066 0.0522 0.0601
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Onchocerca volvulus 0.0015 0.0058 0.0288
Entamoeba histolytica hypothetical protein 0.0033 0.0215 0.4125
Entamoeba histolytica hypothetical protein 0.0033 0.0215 0.4125
Mycobacterium ulcerans hypothetical protein 0.0018 0.0086 0.0524
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0034 0.003
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0075 0.4094
Plasmodium vivax ABC transporter B family member 5, putative 0.0015 0.006 0.0244
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.028 0.2462 0.2855
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0058 0.0062
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.006 0.0065
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0039 0.027 0.1096
Echinococcus multilocularis regulator of G protein signaling 0.003 0.0195 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Echinococcus multilocularis glutathione S transferase 0.0121 0.1021 0.1179
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.0057
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0224 0.2684
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0066 0.0522 0.7789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0444 0.6609
Plasmodium falciparum ABC transporter B family member 3, putative 0.0015 0.006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0031
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0015 0.006 0.325
Echinococcus granulosus regulator of G protein signaling 3 0.003 0.0195 0.0221
Echinococcus granulosus cathepsin l1 0.0015 0.0058 0.0062
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0444 0.6609
Schistosoma mansoni regulator of G protein signaling 0.003 0.0195 0.0226
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0066 0.0522 0.7741
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Brugia malayi ABC transporter transmembrane region family protein 0.0015 0.0055 0.0051
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.003 0.0195 0.0226
Entamoeba histolytica hypothetical protein 0.003 0.0195 0.3729
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.003 0.0195 0.0221
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.002
Brugia malayi Cathepsin L-like precursor 0.0015 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.002
Entamoeba histolytica P-glycoprotein-2 0.0015 0.006 0.115
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0083 0.0089
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0033 0.0224 0.022
Loa Loa (eye worm) RecQ helicase 0.0018 0.0083 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0165 0.0191
Trypanosoma brucei p-glycoprotein 0.0066 0.0522 0.7583
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.0083 0.0424
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0058 0.0067
Entamoeba histolytica ABC transporter, putative 0.0066 0.0522 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0131 0.1109 0.1286
Trypanosoma cruzi co-chaperone GrpE, putative 0.0028 0.0176 0.2598
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.006 0.0065
Leishmania major cathepsin L-like protease 0.0058 0.0444 0.6534
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0141 0.0138
Plasmodium vivax ABC transporter B family member 4, putative 0.0015 0.006 0.0244
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.0207 0.1797 0.9643
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0058 0.0062
Echinococcus granulosus histone acetyltransferase KAT2B 0.0039 0.027 0.0308
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0039 0.027 0.4032
Entamoeba histolytica P-glyco protein 6, putative 0.0015 0.006 0.115
Brugia malayi hypothetical protein 0.0033 0.0215 0.0211
Leishmania major cathepsin L-like protease 0.0015 0.0058 0.0615
Trichomonas vaginalis grpe protein, putative 0.0028 0.0176 0.0926
Loa Loa (eye worm) hypothetical protein 0.0066 0.0522 0.0519
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0215 0.025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0079 0.0076
Brugia malayi Cathepsin L-like precursor 0.0015 0.0058 0.0054
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0083 0.0079
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Plasmodium falciparum ABC transporter B family member 7, putative 0.0015 0.006 0.0008
Brugia malayi regulator of G-protein signaling egl-10 0.003 0.0195 0.0191
Schistosoma mansoni DNA helicase recq5 0.0018 0.0083 0.0096
Brugia malayi PXA domain containing protein 0.003 0.0195 0.0191
Loa Loa (eye worm) hypothetical protein 0.0024 0.0137 0.0134
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0015 0.0055 0.0986
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0058 0.0288
Schistosoma mansoni ap endonuclease 0.0017 0.0075 0.0086
Loa Loa (eye worm) multidrug resistance protein 3 0.0015 0.006 0.0057
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0083 0.0091
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0015 0.006 0.325
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0058 0.0062
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0066 0.0522 0.7583
Echinococcus multilocularis Regulator of G protein signaling 20 0.003 0.0195 0.0221
Entamoeba histolytica hypothetical protein 0.0066 0.0522 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0083 0.1196
Loa Loa (eye worm) fibroinase 0.0015 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.006 0.0466 0.0463
Plasmodium falciparum multidrug resistance protein 2 0.0015 0.006 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0027 0.0165 0.0191
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.0055 0.0059
Trypanosoma cruzi major cysteine proteinase, putative 0.0045 0.0332 0.4929
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0241 0.4611
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0013 0.0034 0.0031
Brugia malayi cathepsin L-like precursor 0.001 0.0012 0.0008
Brugia malayi Glutathione S-transferase 4 0.0207 0.1797 0.1793
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0069 0.0549 0.0545
Brugia malayi Pre-SET motif family protein 0.0188 0.1627 0.1624
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0083 0.0669 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0066 0.0522 0.7741
Echinococcus multilocularis 0.0015 0.006 0.0065
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0058 0.0062
Mycobacterium leprae PROBABLE GRPE PROTEIN (HSP-70 COFACTOR) 0.0028 0.0176 0.2378
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0466 0.0536
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0066 0.0522 0.7583
Loa Loa (eye worm) hypothetical protein 0.003 0.0195 0.0192
Echinococcus multilocularis geminin 0.0153 0.131 0.1515
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.006 0.0301
Trypanosoma brucei multidrug resistance protein E 0.0066 0.0522 0.7583
Leishmania major p-glycoprotein 0.0015 0.006 0.0651
Onchocerca volvulus 0.0015 0.0058 0.0288
Echinococcus granulosus histone lysine methyltransferase setb 0.0027 0.0165 0.0187
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0136 0.0132
Entamoeba histolytica hypothetical protein 0.003 0.0195 0.3729
Entamoeba histolytica P-glycoprotein-2 0.0015 0.006 0.115
Echinococcus granulosus multidrug resistance associated protein 1 0.0066 0.0522 0.0601
Brugia malayi intermediate filament protein 0.0024 0.0141 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Schistosoma mansoni z-protein (S1r protein) 0.003 0.0195 0.0226
Plasmodium falciparum elongation factor 1-gamma, putative 0.0083 0.0669 0.2155
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.006 0.0065
Echinococcus multilocularis bloom syndrome protein 0.0018 0.0083 0.0091
Plasmodium vivax vivapain-2 0.0015 0.0058 0.0234
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Toxoplasma gondii exonuclease III APE 0.0017 0.0075 0.1114
Onchocerca volvulus 0.0024 0.0141 0.0739
Plasmodium falciparum multidrug resistance protein 1 0.0015 0.006 0.0008
Schistosoma mansoni axis inhibition protein axin 0.003 0.0195 0.0226
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0215 0.0245
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.006 0.0065
Brugia malayi A-kinase anchor protein 10, precursor 0.003 0.0195 0.0191
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0083 0.1521
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0039 0.027 0.143
Echinococcus multilocularis regulator of G protein signaling 3 0.003 0.0195 0.0221
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.0057
Plasmodium falciparum ABC transporter B family member 5, putative 0.0015 0.006 0.0008
Brugia malayi ABC transporter 0.0015 0.0055 0.0051
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0083 0.008
Echinococcus multilocularis axis inhibition protein axin 0.003 0.0195 0.0221
Leishmania major cysteine peptidase A (CPA) 0.0015 0.0058 0.0615
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0052
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0055 0.0275
Mycobacterium ulcerans endonuclease IV 0.0069 0.0549 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.003 0.0195 0.0226
Toxoplasma gondii ABC transporter, putative 0.0015 0.006 0.0897
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0292 0.0334
Loa Loa (eye worm) hypothetical protein 0.003 0.0195 0.0192
Chlamydia trachomatis protein GrpE 0.0028 0.0176 0.2378
Echinococcus multilocularis glutathione S transferase 0.0255 0.2232 0.2584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0073 0.0586 0.8743
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.006 0.0065
Brugia malayi Cathepsin L-like precursor 0.0015 0.0058 0.0054
Leishmania major cathepsin L-like protease 0.0058 0.0444 0.6534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Echinococcus granulosus glutathione S transferase 0.0121 0.1021 0.1179
Entamoeba histolytica P-glycoprotein-2, putative 0.0015 0.006 0.115
Loa Loa (eye worm) leucine Rich Repeat family protein 0.0019 0.0092 0.0089
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0083 0.0669 0.0772
Trypanosoma cruzi hypothetical protein 0.0051 0.0382 0.5692
Wolbachia endosymbiont of Brugia malayi molecular chaperone GrpE (heat shock protein) 0.0028 0.0176 1
Plasmodium falciparum ABC transporter B family member 6, putative 0.0015 0.006 0.0008
Brugia malayi multidrug resistance protein 3 0.0015 0.006 0.0056
Echinococcus granulosus grpE protein 1 mitochondrial 0.0028 0.0176 0.02
Brugia malayi regulator of G-protein signaling rgs-7 0.003 0.0195 0.0191
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0586 0.8626
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0075 0.0071
Treponema pallidum grpE protein (grpE) 0.0028 0.0176 1
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0013 0.0034 0.0031
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0398 0.5928
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.006 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0015 0.006 0.0065
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0027 0.0027
Echinococcus granulosus expressed protein 0.0589 0.5264 0.6102
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0083 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0083 0.0089
Onchocerca volvulus 0.0015 0.0058 0.0288
Schistosoma mansoni intermediate filament proteins 0.0024 0.0141 0.0164
Echinococcus granulosus bloom syndrome protein 0.0018 0.0083 0.0091
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0058 0.0054
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.003 0.0195 0.0192
Trichomonas vaginalis ABC transporter, putative 0.0015 0.006 0.0301
Echinococcus granulosus ATP binding cassette sub family B 0.0015 0.0055 0.0059
Loa Loa (eye worm) ABC transporter 0.0015 0.006 0.0057
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.006 0.0301
Giardia lamblia Hypothetical protein 0.0015 0.0055 0.0986
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0364 0.036
Schistosoma mansoni grpe protein 0.0028 0.0176 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0195 0.0226
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0039 0.0036
Plasmodium falciparum glutathione S-transferase 0.0328 0.2897 1
Schistosoma mansoni multidrug resistance protein 0.0066 0.0522 0.0605
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Echinococcus granulosus beta-adrenergic receptor kinase 0.003 0.0195 0.0221
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.006 0.0897
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.0055 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0012 0.0014
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.006 0.0065
Echinococcus granulosus regulator of G protein signaling 7 0.003 0.0195 0.0221
Schistosoma mansoni regulator of G protein signaling 0.003 0.0195 0.0226
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0083 0.0375
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0322 0.0318
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0033 0.0224 0.4282
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0015 0.006 0.0854
Echinococcus granulosus lamin 0.0024 0.0141 0.0159
Schistosoma mansoni hypothetical protein 0.0153 0.131 0.1519
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0083 0.1238
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Schistosoma mansoni lamin 0.0024 0.0141 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.006 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.006 0.0301
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0058 0.0067
Onchocerca volvulus 0.0027 0.0165 0.0867
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0015 0.006 0.0897
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.003 0.0195 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Echinococcus multilocularis regulator of G protein signaling 3 0.003 0.0195 0.0221
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0058 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Brugia malayi ABC transporter 0.0015 0.006 0.0056
Onchocerca volvulus 0.0015 0.0058 0.0288
Onchocerca volvulus 0.0028 0.0176 0.0926
Plasmodium vivax SET domain protein, putative 0.0027 0.0165 0.0671
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0083 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0075 0.0379
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0466 0.0536
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0066 0.0522 0.7741
Leishmania major ABC-thiol transporter 0.0066 0.0522 0.7741
Giardia lamblia ABC transporter, putative 0.0066 0.0522 1
Mycobacterium ulcerans epimerase 0.0018 0.0086 0.0524
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.006 0.0301
Echinococcus granulosus histone acetyltransferase KAT2B 0.0127 0.1076 0.1243
Loa Loa (eye worm) hypothetical protein 0.0207 0.1797 0.1794
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.006 0.0065
Echinococcus granulosus ATP binding cassette sub family B 0.0015 0.006 0.0065
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.003 0.0195 0.0221
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0015 0.006 0.0065
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0075 0.0238
Onchocerca volvulus 0.0015 0.0058 0.0288
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0015 0.006 0.0301
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0083 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0024
Schistosoma mansoni smdr1 0.0015 0.006 0.007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0027 0.0027
Brugia malayi GrpE protein homolog, mitochondrial precursor 0.0028 0.0176 0.0172
Loa Loa (eye worm) hypothetical protein 0.003 0.0195 0.0192
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.096 0.8623 1
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0075 0.0071
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0083 0.0669 1
Brugia malayi ABC transporter family protein 0.0015 0.006 0.0056
Plasmodium falciparum multidrug resistance-associated protein 2 0.0015 0.006 0.0008
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0073 0.0586 0.8743
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0003 0.0047
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.006 0.0065
Echinococcus granulosus glutathione s transferase mu 0.0328 0.2897 0.3356
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0195 0.1026
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0075 0.0874
Echinococcus multilocularis axis inhibition protein axin 0.003 0.0195 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0224 0.1181
Echinococcus granulosus intermediate filament protein 0.0024 0.0141 0.0159
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.006 0.0301
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0058 0.0062
Brugia malayi P-glycoprotein-like protein 0.0015 0.006 0.0056
Leishmania major co-chaperone GrpE, putative 0.0028 0.0176 0.2435
Echinococcus multilocularis multidrug resistance associated protein 1 0.0066 0.0522 0.0601
Echinococcus multilocularis glutathione S transferase 0.0328 0.2897 0.3356
Schistosoma mansoni axis inhibition protein axin 0.003 0.0195 0.0226
Echinococcus multilocularis glutathione S transferase 0.0121 0.1021 0.1179
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.007
Entamoeba histolytica P-glycoprotein 5, putative 0.0015 0.006 0.115
Echinococcus multilocularis glutathione S-transferase 0.0328 0.2897 0.3356
Giardia lamblia MRP-like ABC transporter 0.0066 0.0522 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Schistosoma mansoni multidrug resistance protein 0.0066 0.0522 0.0605
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0075 0.1072
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0083 0.0079
Brugia malayi Bloom's syndrome protein homolog 0.0018 0.0083 0.0079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0027 0.0165 0.0187
Echinococcus granulosus cathepsin l1 0.001 0.0012 0.0009
Entamoeba histolytica hypothetical protein 0.003 0.0195 0.3729
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0241 0.4569
Brugia malayi Cathepsin L-like precursor 0.0015 0.0058 0.0054
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0075 0.0082
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.0224 0.1181
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.006 0.0897
Loa Loa (eye worm) hypothetical protein 0.0066 0.0517 0.0514
Brugia malayi acetyltransferase, GNAT family protein 0.0131 0.1109 0.1105
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0073 0.0586 0.8743
Onchocerca volvulus 0.0024 0.0141 0.0739
Loa Loa (eye worm) glutamate receptor 0.0049 0.0364 0.0361
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0195 0.0226
Echinococcus granulosus axis inhibition protein axin 0.003 0.0195 0.0221
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0083 0.0669 0.0772
Brugia malayi Cathepsin L-like precursor 0.0015 0.0058 0.0054
Echinococcus multilocularis expressed protein 0.0589 0.5264 0.6102
Echinococcus multilocularis glutathione S transferase 0.0328 0.2897 0.3356
Entamoeba histolytica ATP-binding cassette protein, putative 0.0066 0.0522 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0066 0.0522 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0069 0.0549 0.223
Echinococcus granulosus ubiquitin specific protease 41 0.0033 0.0224 0.0255
Plasmodium vivax ABC transporter B family member 7, putative 0.0015 0.006 0.0244
Brugia malayi ABC transporter transmembrane region family protein 0.0066 0.0522 0.0518
Schistosoma mansoni hypothetical protein 0.0033 0.0215 0.025
Toxoplasma gondii ABC transporter family protein 0.0015 0.006 0.0897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0165 0.0191
Loa Loa (eye worm) hypothetical protein 0.003 0.0195 0.0192
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0156 0.0176
Echinococcus granulosus regulator of G protein signaling 7 0.003 0.0195 0.0221
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0131 0.1109 0.1282
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0444 0.6609
Onchocerca volvulus Cathepsin F homolog 0.0015 0.0058 0.0288
Entamoeba histolytica ATP-binding cassette protein, putative 0.0066 0.0522 1
Schistosoma mansoni hypothetical protein 0.0153 0.131 0.1519
Mycobacterium leprae conserved hypothetical protein 0.0018 0.0086 0.0524
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.006 0.0301
Loa Loa (eye worm) hypothetical protein 0.1112 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0058 0.0054
Entamoeba histolytica hypothetical protein 0.0033 0.0215 0.4125
Echinococcus multilocularis cysteine protease 0.0015 0.0058 0.0062
Entamoeba histolytica P-glycoprotein-2, putative 0.0015 0.0055 0.1056
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0069 0.0549 1
Echinococcus granulosus glutathione S transferase 0.0121 0.1021 0.1179
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0075 0.1428
Entamoeba histolytica recQ family DNA helicase 0.0009 0.0003 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Plasmodium falciparum GrpE protein homolog, mitochondrial, putative 0.0028 0.0176 0.0418
Leishmania major pentamidine resistance protein 1 0.0066 0.0522 0.7741
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.003 0.0195 0.0226
Brugia malayi ABC transporter transmembrane region family protein 0.0015 0.006 0.0056
Echinococcus multilocularis glutathione S transferase 0.028 0.2462 0.2852
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Loa Loa (eye worm) cysteine protease 0.0015 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0195 0.0192
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0015 0.006 0.0651
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0424 0.0492
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0141 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Entamoeba histolytica P-glycoprotein 6, putative 0.0015 0.006 0.115
Trichomonas vaginalis ABC transporter, putative 0.0015 0.006 0.0301
Echinococcus multilocularis regulator of G protein signaling 7 0.003 0.0195 0.0221
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.003 0.0195 0.0191
Echinococcus multilocularis grpE protein 1, mitochondrial 0.0028 0.0176 0.02
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0224 0.3309
Schistosoma mansoni multidrug resistance protein 0.0015 0.006 0.007
Brugia malayi Regulator of G protein signaling domain containing protein 0.003 0.0195 0.0191
Echinococcus granulosus glutathione S transferase Mu 1 0.0695 0.622 0.7212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Trypanosoma brucei co-chaperone GrpE, putative 0.0028 0.0176 0.1907
Loa Loa (eye worm) glutamate receptor 0.0019 0.0095 0.0092
Trichomonas vaginalis set domain proteins, putative 0.0214 0.1863 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.006 0.0897
Onchocerca volvulus 0.0015 0.0058 0.0288
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0075 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Leishmania major cathepsin L-like protease 0.0015 0.0058 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0195 0.1026
Entamoeba histolytica P-glycoprotein-5 0.0015 0.006 0.115
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.006 0.0897
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0195 0.0226
Loa Loa (eye worm) ctsf protein 0.0015 0.0058 0.0054
Chlamydia trachomatis endonuclease IV 0.0069 0.0549 1
Brugia malayi indoleamine 2,3-dioxygenase 0.096 0.8623 0.8623
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0058 0.0288
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.006 0.0897
Echinococcus granulosus glutathione S transferase 0.0328 0.2897 0.3356
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0444 0.6609
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0015 0.006 0.0897
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0015 0.006 0.0301
Onchocerca volvulus 0.0015 0.006 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0058 0.0288
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0241 0.0645
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0083 0.0669 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Trypanosoma brucei elongation factor 1 gamma, putative 0.0083 0.0669 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0015 0.0055 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0086 0.0524
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0292 0.0338
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0015 0.006 0.0854
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0015 0.0055 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0033 0.0224 0.0259
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.0055 0.0275
Leishmania major cathepsin L-like protease 0.0015 0.0058 0.0615
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0075 0.1072
Toxoplasma gondii endonuclease IV APN 0.0069 0.0549 0.82
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0082
Mycobacterium tuberculosis Probable GrpE protein (HSP-70 cofactor) 0.0018 0.0079 0.0388
Schistosoma mansoni GST class-mu 0.0328 0.2897 0.3359
Trichomonas vaginalis grpe protein, putative 0.0028 0.0176 0.0926
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0069 0.0549 0.173
Echinococcus multilocularis prostaglandin H2 D isomerase 0.028 0.2462 0.2852
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.0138
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0073 0.0586 0.8743
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0224 0.3309
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0075 0.0297
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0018 0.0086 0.0082
Trypanosoma cruzi multidrug resistance protein E, putative 0.0066 0.0522 0.7789
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0069 0.0549 1
Loa Loa (eye worm) acetyltransferase 0.0131 0.1109 0.1106
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0054
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0033 0.0224 0.0255
Loa Loa (eye worm) multidrug resistance-associated protein 0.0052 0.0387 0.0384
Entamoeba histolytica multidrug resistance protein, putative 0.0066 0.0522 1
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0141 0.0138
Loa Loa (eye worm) hypothetical protein 0.0066 0.0522 0.0519
Echinococcus multilocularis beta adrenergic receptor kinase 0.003 0.0195 0.0221
Echinococcus multilocularis lamin dm0 0.0024 0.0141 0.0159
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0033 0.0224 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0033 0.0224 0.4238
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0292 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0195 0.1026
Loa Loa (eye worm) RGS-3 protein 0.003 0.0195 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0136 0.0158
Leishmania major p-glycoprotein e 0.0066 0.0522 0.7741
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.0083 0.1002
Brugia malayi Cathepsin L-like precursor 0.0015 0.0058 0.0054
Entamoeba histolytica ATP-binding cassette protein, putative 0.0066 0.0522 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.006 0.0301
Plasmodium vivax GrpE protein homolog, mitochondrial, putative 0.0028 0.0176 0.0716
Loa Loa (eye worm) hypothetical protein 0.0033 0.0224 0.0221
Loa Loa (eye worm) hypothetical protein 0.0069 0.0549 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0058 0.0288
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0015 0.006 0.0244
Echinococcus granulosus ATP binding cassette sub family B 0.0015 0.006 0.0065
Schistosoma mansoni regulator of G protein signaling 0.003 0.0195 0.0226
Schistosoma mansoni glutathione-S-transferase 0.0328 0.2897 0.3359
Onchocerca volvulus 0.0214 0.1863 1
Leishmania major hypothetical protein, conserved 0.0073 0.0586 0.8715
Loa Loa (eye worm) hypothetical protein 0.0027 0.0165 0.0162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0027 0.0165 0.2467
Plasmodium vivax multidrug resistance protein 1, putative 0.0015 0.006 0.0244
Echinococcus multilocularis ATP binding cassette sub family B 0.0015 0.006 0.0065
Echinococcus granulosus multidrug resistance associated protein 4 0.0051 0.0382 0.0439
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.000000000067043
Trichomonas vaginalis abcb9, putative 0.0015 0.006 0.0301
Onchocerca volvulus 0.0207 0.1797 0.9643
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.006 0.0301
Schistosoma mansoni regulator of G protein signaling 0.003 0.0195 0.0226
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0075 0.0082
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0083 0.0669 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0015 0.006 0.0301
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0052
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0015 0.006 0.0056
Echinococcus granulosus regulator of G protein signaling 3 0.003 0.0195 0.0221
Entamoeba histolytica cysteine protease, putative 0.0015 0.0058 0.1104
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0018 0.0086 0.0439
Loa Loa (eye worm) hypothetical protein 0.003 0.0195 0.0192
Brugia malayi Cathepsin L-like precursor 0.001 0.0012 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Schistosoma mansoni multidrug resistance protein 0.0066 0.0522 0.0605
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0058 0.0062
Brugia malayi ABC transporter family protein 0.0015 0.006 0.0056
Schistosoma mansoni regulator of G protein signaling 0.003 0.0195 0.0226
Trichomonas vaginalis abcb9, putative 0.0015 0.006 0.0301
Trichomonas vaginalis bromodomain-containing protein, putative 0.0039 0.027 0.143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0444 0.6293
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.096 0.8623 0.8623
Trichomonas vaginalis taga, putative 0.0015 0.006 0.0301
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0058 0.1104
Loa Loa (eye worm) PXA domain-containing protein 0.003 0.0195 0.0192
Schistosoma mansoni hypothetical protein 0.096 0.8623 1
Leishmania major cathepsin L-like protease 0.0015 0.0058 0.0615
Toxoplasma gondii cathepsin CPL 0.0015 0.0058 0.0861
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0188 0.1627 0.1625
Loa Loa (eye worm) ABC transporter 0.0015 0.006 0.0057
Plasmodium falciparum ABC transporter B family member 4, putative 0.0015 0.006 0.0008
Schistosoma mansoni DNA helicase recq1 0.0018 0.0083 0.0096
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0066 0.0522 0.7789
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0075 0.0379
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0083 0.0669 1
Giardia lamblia Hypothetical protein 0.0011 0.0018 0.0261
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0015 0.006 0.0651
Toxoplasma gondii elongation factor 1-gamma, putative 0.0083 0.0669 1
Schistosoma mansoni smdr2 0.0015 0.006 0.007
Schistosoma mansoni ap endonuclease 0.0017 0.0075 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0058 0.0818
Echinococcus granulosus lamin dm0 0.0024 0.0141 0.0159
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0066 0.0522 0.7741
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0066 0.0522 0.78
Echinococcus granulosus prostaglandin H2 D isomerase 0.028 0.2462 0.2852
Brugia malayi Pre-SET motif family protein 0.0027 0.0165 0.0161
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0015 0.006 0.0651
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0073 0.0586 0.8743
Echinococcus multilocularis ubiquitin specific protease 41 0.0033 0.0224 0.0255
Echinococcus multilocularis glutathione S transferase 0.0255 0.2232 0.2584
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0015 0.006 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0012 0.0044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0075 0.1361
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.0083 0.0424
Echinococcus multilocularis lamin 0.0024 0.0141 0.0159
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0015 0.006 0.0897
Onchocerca volvulus 0.0015 0.0058 0.0288
Trichomonas vaginalis abcb9, putative 0.0015 0.006 0.0301

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.9 nM Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as increase of L-glutamate-induced calcium mobilization by FLIPR assay ChEMBL. 21531137
Emax (binding) = 109 % Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as increase of L-glutamate-induced calcium mobilization at 10 uM by FLIPR assay relative to L-glutamate ChEMBL. 21531137
Ki (binding) = 0.89 uM Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrs ChEMBL. 21531137

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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