TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 340.499 | Formula: C23H32O2
H donors: 0 H acceptors: 1 LogP: 7.6 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC(=O)Oc1ccc(cc1)/C=C/[C@@](CCC=C(C)C)(C=C)C
InChi: 1S/C23H32O2/c1-6-8-11-22(24)25-21-14-12-20(13-15-21)16-18-23(5,7-2)17-9-10-19(3)4/h7,10,12-16,18H,2,6,8-9,11,17H2,1,3-5H3/b18-16+/t23-/m1/s1
InChiKey: BIPDYVBHHMSGRN-YJCCFKNTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	SMO-1 protein	0.0031	0.0315	0.089
Loa Loa (eye worm)	hypothetical protein	0.0008	0.004	0.0112
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0234	0.066
Schistosoma mansoni	DNA helicase recq1	0.001	0.0062	0.0077
Entamoeba histolytica	hypothetical protein	0.0011	0.0072	0.1853
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0097	0.209
Loa Loa (eye worm)	hypothetical protein	0.0008	0.004	0.0112
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0066	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0321	0.0321
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.1143	0.3226
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.004	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0714	0.089
Trypanosoma cruzi	small ubiquitin protein, putative	0.0031	0.0315	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.004	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0066	0.0187
Brugia malayi	hypothetical protein	0.0008	0.004	0.0112
Onchocerca volvulus		0.0011	0.0066	0.9215
Echinococcus granulosus	cation transporting ATPase 13A3	0.0008	0.004	0.005
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0008	0.004	0.1193
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0321	0.0907
Echinococcus granulosus	cation transporting atpase worm	0.0008	0.004	0.005
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0072	0.0203
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0008	0.004	0.004
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0066	0.0187
Giardia lamblia	Sentrin	0.0031	0.0315	1
Trypanosoma brucei	small ubiquitin-related modifier	0.0031	0.0315	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.004	0.005
Plasmodium falciparum	small ubiquitin-related modifier	0.0031	0.0315	0.0814
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0008	0.004	0.005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.002
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0066	0.0187
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0007	0.002
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0292	0.3424	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Toxoplasma gondii	P-type ATPase4, putative	0.0008	0.004	0.1193
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0062	0.0077
Brugia malayi	Ubiquitin-like protein SMT3	0.0031	0.0315	0.089
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0973	0.2745
Entamoeba histolytica	recQ family DNA helicase	0.0005	0.0003	0.0061
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0066	0.0083
Schistosoma mansoni	hypothetical protein	0.0032	0.0321	0.04
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0066	0.9215
Schistosoma mansoni	smad1 5 8 and	0.0008	0.004	0.005
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0973	0.2745
Echinococcus granulosus	cation transporting ATPase 13A1	0.0008	0.004	0.005
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0008	0.004	0.1025
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0066	0.0187
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0315	1
Trypanosoma cruzi	small ubiquitin protein, putative	0.0031	0.0315	1
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0008	0.004	0.005
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0137	0.4288
Echinococcus multilocularis	muscleblind protein	0.0302	0.3543	0.3543
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.004	0.004
Schistosoma mansoni	DNA helicase recq5	0.001	0.0062	0.0077
Echinococcus multilocularis	geminin	0.0173	0.2009	0.2009
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.004	0.004
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0714	0.089
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0066	0.9215
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0008	0.004	0.1193
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0097	0.209
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0008	0.004	0.005
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0066	0.0187
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.004	0.004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1067	0.133
Onchocerca volvulus		0.0008	0.004	0.5541
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0008	0.004	0.1025
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0714	0.2016
Schistosoma mansoni	hypothetical protein	0.0032	0.0321	0.04
Loa Loa (eye worm)	hypothetical protein	0.0302	0.3543	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.004	0.0112
Plasmodium vivax	P-type ATPase4, putative	0.0008	0.004	0.0116
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0008	0.004	0.0112
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0066	0.0187
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0387	0.0483
Entamoeba histolytica	hypothetical protein	0.0037	0.0387	1
Brugia malayi	hypothetical protein	0.0037	0.0387	0.1093
Entamoeba histolytica	hypothetical protein	0.0037	0.0387	1
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0008	0.004	0.1193
Schistosoma mansoni	hypothetical protein	0.0173	0.2009	0.2505
Brugia malayi	hypothetical protein	0.0011	0.0072	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0066	0.0187
Schistosoma mansoni	Smad4	0.0008	0.004	0.005
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0714	0.089
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0387	0.0483
Toxoplasma gondii	cation-transporting atpase family protein	0.0008	0.004	0.1193
Schistosoma mansoni	hypothetical protein	0.0069	0.0763	0.0951
Loa Loa (eye worm)	Smad1	0.0008	0.004	0.0113
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0066	0.0187
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1398	0.3946
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0321	0.0321
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0008	0.004	0.1025
Schistosoma mansoni	eyes absent homolog	0.0086	0.0973	0.1213
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0008	0.004	0.004
Brugia malayi	MH2 domain containing protein	0.0008	0.004	0.0113
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.1067	0.133
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0066	0.0083
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0066	0.0083
Schistosoma mansoni	blooms syndrome DNA helicase	0.0005	0.0003	0.0003
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0234	0.7044
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0008	0.004	0.004
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.004	0.005
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0008	0.004	0.005
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.0139	0.0405
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.004	0.005
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.1067	0.3011
Schistosoma mansoni	cation-transporting ATPase	0.0008	0.004	0.005
Entamoeba histolytica	hypothetical protein	0.0037	0.0387	1
Echinococcus multilocularis	muscleblind protein 1	0.0302	0.3543	0.3543
Echinococcus multilocularis	microtubule associated protein 2	0.0677	0.8021	0.8021
Brugia malayi	Muscleblind-like protein	0.0302	0.3543	1
Schistosoma mansoni	smad	0.0008	0.004	0.005
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0007	0.0009
Plasmodium vivax	calcium-transporting ATPase, putative	0.0008	0.004	0.0116
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0008	0.004	0.004
Schistosoma mansoni	type V p-type atpase isoform	0.0008	0.004	0.005
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0172	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0302	0.3543	1
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0008	0.004	0.1193
Brugia malayi	steroid hormone receptor	0.0011	0.0066	0.0187
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.004	0.0113
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0008	0.004	0.1025
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.0173	0.2009	0.2505
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0031	0.0315	0.0393
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1067	0.1067
Echinococcus granulosus	muscleblind protein	0.0302	0.3543	0.4417
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0714	0.2016
Loa Loa (eye worm)	calcium ATPase	0.0008	0.004	0.0112
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.1067	0.3011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0066	0.0187
Brugia malayi	nuclear receptor RXR	0.0006	0.0007	0.002
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0714	0.2016
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.1143	0.3226
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.1067	0.1067
Echinococcus granulosus	microtubule associated protein 2	0.0677	0.8021	1
Trichomonas vaginalis	ubiquitin, putative	0.0011	0.0072	0.1163
Entamoeba histolytica	ubiquitin like protein	0.0031	0.0315	0.8145
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0321	0.04
Echinococcus granulosus	Smad4	0.0008	0.004	0.005
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1067	0.133
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0008	0.004	0.005
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0008	0.004	0.1025
Trypanosoma cruzi	proton motive ATPase 1, putative	0.0008	0.004	0.1193
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0066	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.002
Brugia malayi	E1-E2 ATPase family protein	0.0008	0.004	0.0112
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0062	0.0077
Brugia malayi	MH2 domain containing protein	0.0008	0.004	0.0113
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0062	0.0062
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0008	0.004	0.1193
Plasmodium vivax	cation transporting ATPase, putative	0.0008	0.004	0.0116
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0008	0.004	0.1193
Brugia malayi	Na,K-ATPase alpha subunit	0.0008	0.004	0.0112
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.0008	0.004	0.0112
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.004	0.004
Brugia malayi	MH1 domain containing protein	0.0008	0.004	0.0113
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0008	0.004	0.1025
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0066	0.0187
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0066	0.0187
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0066	0.0083
Brugia malayi	hypothetical protein	0.0006	0.0007	0.002
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0008	0.004	0.005
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Brugia malayi	E1-E2 ATPase family protein	0.0008	0.004	0.0112
Schistosoma mansoni	coup transcription factor	0.0011	0.0066	0.0083
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0292	0.3424	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0066	0.0187
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0066	0.9215
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0763	0.2152
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0066	0.0066
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0066	0.0187
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0066	0.0083
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0066	0.0187
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0008	0.004	0.1193
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0008	0.004	0.005
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0292	0.3424	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0066	0.0066
Brugia malayi	hypothetical protein	0.0086	0.0973	0.2745
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0097	0.209
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0066	0.0083
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0066	0.0083
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.0008	0.004	0.1025
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0066	0.0187
Loa Loa (eye worm)	hypothetical protein	0.001	0.0062	0.0175
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0066	0.0083
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.0008	0.004	0.1193
Schistosoma mansoni	ATPase	0.0008	0.004	0.005
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0008	0.004	0.1025
Loa Loa (eye worm)	E1-E2 ATPase	0.0008	0.004	0.0112
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0714	0.2016
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0066	0.0066
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0066	0.0066
Brugia malayi	Smad1	0.0008	0.004	0.0113
Echinococcus granulosus	ubiquitin	0.0011	0.0072	0.009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1067	0.133
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.0008	0.004	0.0112
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0234	0.0234
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.1143	0.3226
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0234	0.7044
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0292	0.3424	1
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0008	0.004	0.0112
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0292	0.3424	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0062	0.0175
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.002
Brugia malayi	MH1 domain containing protein	0.0008	0.004	0.0113
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0007	0.0009
Schistosoma mansoni	hypothetical protein	0.0037	0.0387	0.0483
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0714	0.089
Schistosoma mansoni	hypothetical protein	0.0032	0.0321	0.04
Echinococcus multilocularis	ubiquitin	0.0011	0.0072	0.0072
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0008	0.004	0.0112
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0066	0.0083
Brugia malayi	RNA binding protein	0.0065	0.0714	0.2016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.1067	0.133
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0066	0.0083
Echinococcus multilocularis	copper transporting ATPase 1	0.0008	0.004	0.004
Echinococcus granulosus	copper transporting ATPase 1	0.0008	0.004	0.005
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0097	0.3033
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0007	0.0009
Brugia malayi	hypothetical protein	0.0006	0.0007	0.002
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0066	0.0083
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0008	0.004	0.1193
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0066	0.0083
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0066	0.0187
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0097	0.2513
Schistosoma mansoni	phosphoserine phosphatase	0.0008	0.004	0.005
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0321	0.0907
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0008	0.004	0.1193
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0062	0.0799
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0321	0.0907
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0066	0.0066
Schistosoma mansoni	smad1 5 8 and	0.0008	0.004	0.005
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0234	0.066
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0008	0.004	0.004
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0234	0.0292
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0066	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0007
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0008	0.004	0.1193
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0008	0.004	0.004
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0031	0.0315	0.092
Brugia malayi	ecdysteroid receptor	0.0011	0.0066	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0008	0.004	0.0112
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0062	0.0175
Brugia malayi	TAR-binding protein	0.0065	0.0714	0.2016
Brugia malayi	nuclear hormone receptor	0.0011	0.0066	0.0187
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0066	0.0187
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0066	0.0083
Schistosoma mansoni	ATPase	0.0008	0.004	0.005
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0008	0.004	0.1193
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0066	0.0187
Schistosoma mansoni	hypothetical protein	0.0032	0.0321	0.04
Treponema pallidum	cation-transporting ATPase, P-type	0.0008	0.004	0.0109
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.004	0.004
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0008	0.004	0.1193
Trypanosoma cruzi	cation-transporting ATPase, putative	0.0008	0.004	0.1193
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0714	0.089
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0321	0.0321
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1398	0.3946
Schistosoma mansoni	microtubule-associated protein tau	0.0677	0.8021	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0072	0.1163
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0008	0.004	0.1193
Treponema pallidum	hypothetical protein	0.0008	0.004	0.0109
Brugia malayi	MH2 domain containing protein	0.0122	0.1398	0.3946
Schistosoma mansoni	copper ABC transporter ATPase	0.0008	0.004	0.005
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0008	0.004	0.004
Echinococcus multilocularis	Smad4	0.0008	0.004	0.004
Onchocerca volvulus		0.0011	0.0072	1
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0031	0.0315	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0763	0.2152
Toxoplasma gondii	P-type ATPase PMA1	0.0008	0.004	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.002
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0062	0.1896
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0321	0.0907
Chlamydia trachomatis	metal transport ATPase	0.0008	0.004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0187
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0066	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0008	0.004	0.0112
Echinococcus granulosus	GPCR family 2	0.0032	0.0321	0.04
Trypanosoma cruzi	phospholipid-transporting ATPase-like protein, putative	0.0008	0.004	0.1193
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0321	0.04
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0066	0.0083
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.001	0.0062	0.0065
Trypanosoma cruzi	copper-transporting ATPase, putative	0.0008	0.004	0.1193
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0066	0.0083
Schistosoma mansoni	smad1 5 8 and	0.0008	0.004	0.005
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0066	0.0083
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0008	0.004	0.0112
Echinococcus granulosus	smad	0.0008	0.004	0.005
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0008	0.004	0.1025
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0066	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0066	0.0187
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0066	0.0083
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0008	0.004	0.1025
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0008	0.004	0.1193
Plasmodium vivax	copper-transporting ATPase, putative	0.0008	0.004	0.0116
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.004	0.004
Entamoeba histolytica	hypothetical protein	0.0037	0.0387	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0198	0.0468
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0066	0.0083
Echinococcus granulosus	Small ubiquitin modifier 2	0.0031	0.0315	0.0393
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0066	0.0187
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0387	0.0387
Schistosoma mansoni	cation-transporting atpase worm	0.0008	0.004	0.005
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0031	0.0315	0.0315
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1416	0.3996
Schistosoma mansoni	atpase class VI type 11c	0.0008	0.004	0.005
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0007	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0066	0.0187
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0714	0.0714
Treponema pallidum	hypothetical protein	0.0292	0.3424	1
Echinococcus multilocularis	cation transporting atpase worm	0.0008	0.004	0.004
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0062	0.0062
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0066	0.0187
Echinococcus granulosus	geminin	0.0173	0.2009	0.2505
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1143	0.3226
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0062	0.0175
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0066	0.0083
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0066	0.0066
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0714	0.089
Echinococcus multilocularis	smad	0.0008	0.004	0.004
Schistosoma mansoni	cation-transporting atpase worm	0.0008	0.004	0.005
Leishmania major	small ubiquitin protein, putative	0.0031	0.0315	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0062	0.1896
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.004	0.004
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0066	0.0066

Activities

Activity type	Activity value	Assay description	Source	Reference
GI (functional)	= 3 %	Growth inhibition of human OVCAR5 cells at 50 uM after 48 hrs by sulpharhodamine B assay	ChEMBL.	22245048
GI (functional)	= 15 %	Growth inhibition of human THP1 cells at 50 uM after 48 hrs by sulpharhodamine B assay	ChEMBL.	22245048
GI (functional)	= 21 %	Growth inhibition of human IMR32 cells at 50 uM after 48 hrs by sulpharhodamine B assay	ChEMBL.	22245048
GI (functional)	= 23 %	Growth inhibition of human HeLa cells at 50 uM after 48 hrs by sulpharhodamine B assay	ChEMBL.	22245048
GI (functional)	= 25 %	Growth inhibition of human MCF7 cells at 50 uM after 48 hrs by sulpharhodamine B assay	ChEMBL.	22245048
GI (functional)	= 38 %	Growth inhibition of human A549 cells at 50 uM after 48 hrs by sulpharhodamine B assay	ChEMBL.	22245048
GI (functional)	= 42 %	Growth inhibition of human PC3 cells at 50 uM after 48 hrs by sulpharhodamine B assay	ChEMBL.	22245048

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1946501

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1568577