TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 812.942 | Formula: C50H52O10
H donors: 6 H acceptors: 7 LogP: 12.53 Rotable bonds: 11
Rule of 5 violations (Lipinski): 3
SMILES: CC(=CCc1c2O[C@@H]3[C@H](c2cc(c1O)C(=O)c1c(oc2c1cc(O)c(c2CC=C(C)C)O)c1cc(CC=C(C)C)c(cc1O)O)COc1c3ccc(c1CC=C(C)C)O)C
InChi: 1S/C50H52O10/c1-24(2)9-13-28-19-34(40(53)22-39(28)52)50-42(35-21-41(54)44(56)31(48(35)60-50)16-12-27(7)8)45(57)36-20-33-37-23-58-46-29(14-10-25(3)4)38(51)18-17-32(46)49(37)59-47(33)30(43(36)55)15-11-26(5)6/h9-12,17-22,37,49,51-56H,13-16,23H2,1-8H3/t37-,49-/m0/s1
InChiKey: KYGKFGJZDFSTOO-HNKXTRRSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Patched related family protein 10	0.0018	0.0022	0.0058
Mycobacterium ulcerans	hypothetical protein	0.0302	0.3359	0.4021
Onchocerca volvulus		0.0107	0.1072	0.2798
Mycobacterium ulcerans	lipase LipD	0.0107	0.1072	0.0828
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Echinococcus granulosus	Protein patched homolog 1	0.0128	0.1316	0.1316
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.1072	0.3082
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0413	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Onchocerca volvulus		0.0042	0.0308	0.0763
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0308	0.0773
Brugia malayi	Synaptic glycoprotein SC2	0.0042	0.0308	0.0817
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0042	0.0308	0.0308
Loa Loa (eye worm)	patched family protein	0.0018	0.0022	0.0058
Schistosoma mansoni	hypothetical protein	0.0124	0.1261	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0107	0.1072	0.0802
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.1072	0.3082
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1072	0.284
Loa Loa (eye worm)	hypothetical protein	0.004	0.0274	0.0725
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0244	0.0244
Schistosoma mansoni	hypothetical protein	0.0036	0.0237	0.0237
Brugia malayi	Patched related family protein 4	0.0018	0.0022	0.0058
Trichomonas vaginalis	ap endonuclease, putative	0.0057	0.0479	0.1289
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0437	0.0437
Loa Loa (eye worm)	patched family protein	0.0018	0.0022	0.0058
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0057	0.0479	0.1171
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0107	0.1072	0.1072
Brugia malayi	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.005	0.04	0.1061
Plasmodium falciparum	polyprenol reductase, putative	0.0042	0.0308	0.6269
Brugia malayi	Pre-SET motif family protein	0.0216	0.2352	0.6233
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Schistosoma mansoni	hypothetical protein	0.0838	0.966	0.966
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0302	0.3359	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1072	0.284
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0042	0.0308	0.0308
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0437	0.0437
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0057	0.0479	0.4352
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0194	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0308	0.0817
Loa Loa (eye worm)	beta-lactamase	0.0107	0.1072	0.284
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0042	0.0308	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Brugia malayi	protein C24B5.3	0.0018	0.0022	0.0058
Entamoeba histolytica	hypothetical protein	0.0042	0.0308	0.0228
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0302	0.0801
Mycobacterium ulcerans	pantoate--beta-alanine ligase	0.0666	0.7642	1
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0042	0.0308	0.0308
Schistosoma mansoni	cpg binding protein	0.0099	0.0969	0.0969
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.04	0.04
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0194	0.0194
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0024	0.0089	0.0089
Trypanosoma brucei	hypothetical protein, conserved	0.0107	0.1072	0.2988
Schistosoma mansoni	hypothetical protein	0.0124	0.1261	0.1261
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0028	0.0143	0.0143
Echinococcus granulosus	sterol regulatory element binding protein	0.0128	0.1316	0.1316
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0068	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0124	0.1261	0.1261
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.144	0.3816
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0413	0.1093
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0302	0.3359	0.8901
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Onchocerca volvulus		0.0337	0.3774	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Echinococcus granulosus	histone lysine methyltransferase setb	0.005	0.04	0.04
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0091	0.0884	0.2343
Echinococcus granulosus	Niemann Pick C1 protein	0.0427	0.4827	0.4827
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1655	0.4385
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.27	0.8008
Brugia malayi	MH2 domain containing protein	0.0139	0.144	0.3816
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1072	0.284
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.1072	0.3082
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0057	0.0479	0.0479
Mycobacterium tuberculosis	Probable lipase LipE	0.0107	0.1072	0.0802
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0023	0.0061
Brugia malayi	hypothetical protein	0.0337	0.3774	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0057	0.0479	1
Mycobacterium tuberculosis	Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.0666	0.7642	0.9683
Schistosoma mansoni	microtubule-associated protein tau	0.0711	0.8164	0.8164
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1072	0.284
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Echinococcus granulosus	zinc finger protein	0.0025	0.0107	0.0107
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0042	0.0308	0.0308
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0029	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0308	0.0773
Brugia malayi	Patched protein homolog 1	0.0018	0.0022	0.0058
Loa Loa (eye worm)	histone methyltransferase	0.0029	0.0155	0.0411
Plasmodium vivax	polyprenol reductase, putative	0.0042	0.0308	0.2728
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0302	0.3359	1
Mycobacterium tuberculosis	Conserved protein	0.0107	0.1072	0.0802
Brugia malayi	F/Y-rich N-terminus family protein	0.0031	0.0174	0.0461
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0059	0.0156
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0803	0.9246	0.9246
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.1072	0.2988
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0302	0.3359	1
Brugia malayi	hypothetical protein	0.0018	0.0022	0.0058
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0042	0.0308	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0097	0.0257
Echinococcus granulosus	expressed conserved protein	0.028	0.3107	0.3107
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1072	0.284
Echinococcus multilocularis	geminin	0.0867	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0437	0.0437
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0107	0.1072	0.284
Plasmodium vivax	SET domain protein, putative	0.0033	0.0194	0.1638
Brugia malayi	Niemann-Pick C1 protein precursor	0.0299	0.332	0.8798
Trichomonas vaginalis	ap endonuclease, putative	0.0057	0.0479	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0608	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Schistosoma mansoni	cpg binding protein	0.0099	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0437	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0015	0.0015
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.1072	0.1072
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.1072	0.3082
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0068	0.0608	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0665	0.1763
Toxoplasma gondii	ABC1 family protein	0.0107	0.1072	0.1378
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1316	0.3487
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.0042	0.0308	0.0228
Toxoplasma gondii	pantoate-beta-alanine ligase	0.0666	0.7642	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.0593	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0222	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0387	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0097	0.164
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0042	0.0308	0.2728
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0057	0.0479	0.1171
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0195	0.2103	0.2103
Echinococcus granulosus	synaptic glycoprotein sc2	0.0042	0.0308	0.0308
Schistosoma mansoni	hypothetical protein	0.0021	0.0059	0.0059
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Brugia malayi	protein C24B5.3	0.0018	0.0022	0.0058
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0303	0.3375	0.3375
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0107	0.1072	0.0828
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0057	0.0479	0.5
Brugia malayi	exodeoxyribonuclease III family protein	0.0057	0.0479	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0302	0.3359	1
Schistosoma mansoni	patched 1	0.0128	0.1316	0.1316
Brugia malayi	Bromodomain containing protein	0.0039	0.0273	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0107	0.1072	0.0802
Brugia malayi	CHE-14 protein	0.0128	0.1316	0.3487
Schistosoma mansoni	hypothetical protein	0.0035	0.0222	0.0222
Mycobacterium tuberculosis	Probable hydrolase	0.0107	0.1072	0.0802
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0437	0.0437
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0042	0.0308	0.0773
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0068	0.0608	0.0608
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0222	0.0587
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0097	0.0098
Echinococcus multilocularis	microtubule associated protein 2	0.0711	0.8164	0.8164
Loa Loa (eye worm)	hypothetical protein	0.0337	0.3774	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.2352	0.6233
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Echinococcus multilocularis	protein patched	0.0128	0.1316	0.1316
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Echinococcus multilocularis	dnaJ subfamily B	0.0838	0.966	0.966
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0302	0.3359	1
Brugia malayi	PHD-finger family protein	0.0031	0.0172	0.0456
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0237	0.0237
Schistosoma mansoni	ap endonuclease	0.0057	0.0479	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0413	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0068	0.0608	0.1612
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0237	0.0237
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0177	0.1888	0.2449
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0042	0.0308	0.0376
Schistosoma mansoni	cpg binding protein	0.0091	0.0884	0.0884
Echinococcus multilocularis	sterol regulatory element binding protein	0.0128	0.1316	0.1316
Brugia malayi	beta-lactamase family protein	0.0107	0.1072	0.284
Echinococcus multilocularis	Niemann Pick C1 protein	0.0427	0.4827	0.4827
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Brugia malayi	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0299	0.332	0.8798
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Onchocerca volvulus		0.0033	0.0194	0.0458
Echinococcus multilocularis	Niemann Pick C1 protein	0.0299	0.332	0.332
Loa Loa (eye worm)	hypothetical protein	0.0302	0.3359	0.8901
Schistosoma mansoni	hypothetical protein	0.0867	1	1
Brugia malayi	Bromodomain containing protein	0.0082	0.0778	0.2063
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0057	0.0479	0.5
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0042	0.0308	0.0648
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.1072	0.3082
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0128	0.1316	0.3487
Echinococcus granulosus	dnaJ subfamily B	0.0838	0.966	0.966
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0107	0.1072	0.284
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.005	0.04	0.04
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.144	0.3816
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.0593	0.0593
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0057	0.0479	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Brugia malayi	Myosin head containing protein	0.0018	0.0022	0.0058
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Echinococcus granulosus	Niemann Pick C1 protein	0.0299	0.332	0.332
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Schistosoma mansoni	ap endonuclease	0.0057	0.0479	0.0479
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0024	0.0089	0.0089
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0068	0.0608	0.1189
Echinococcus multilocularis	zinc finger protein	0.0025	0.0107	0.0107
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0302	0.3359	1
Schistosoma mansoni	hypothetical protein	0.0867	1	1
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0042	0.0308	0.0376
Schistosoma mansoni	bromodomain containing protein	0.007	0.0636	0.0636
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0686	0.7876	1
Leishmania major	hypothetical protein, conserved	0.0107	0.1072	0.2988
Brugia malayi	CXXC zinc finger family protein	0.0091	0.0884	0.2343
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.1072	0.2988
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Brugia malayi	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0042	0.0308	0.0773
Onchocerca volvulus		0.0107	0.1072	0.2798
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0302	0.3359	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0107	0.1072	0.0802
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0244	0.0244
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0437	0.0437
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0272	0.0272
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0024	0.0089	0.0089
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0157	0.0157
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0437	0.1159
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.1072	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	patched family protein	0.0018	0.0022	0.0058
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0042	0.0308	0.0648
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0057	0.0479	1
Loa Loa (eye worm)	patched family protein	0.0018	0.0022	0.0058
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0608	0.1568
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0057	0.0479	0.0479
Brugia malayi	beta-lactamase family protein	0.0107	0.1072	0.284
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0057	0.0479	0.0774
Trichomonas vaginalis	esterase, putative	0.0107	0.1072	0.3082
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0042	0.0308	0.0308
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0097	0.164
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Brugia malayi	hypothetical protein	0.0036	0.0237	0.0628
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0194	0.0194
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0302	0.3359	0.438
Mycobacterium leprae	Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.0666	0.7642	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0107	0.1072	0.0802
Onchocerca volvulus		0.0091	0.0884	0.2298
Mycobacterium ulcerans	esterase/lipase LipP	0.0107	0.1072	0.0828
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0107	0.1072	0.0802
Brugia malayi	hypothetical protein	0.0024	0.0097	0.0257
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0015	0.0015
Brugia malayi	beta-lactamase	0.0107	0.1072	0.284
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0097	0.0714
Echinococcus multilocularis	protein dispatched 1	0.0146	0.1529	0.1529
Echinococcus granulosus	fetal alzheimer antigen falz	0.0028	0.0143	0.0143
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0042	0.0308	0.6269
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0024	0.0089	0.0089
Mycobacterium ulcerans	beta-lactamase	0.0107	0.1072	0.0828
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0029	0.0155	0.0155
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.04	0.04
Brugia malayi	Patched related family protein 12	0.0018	0.0022	0.0058
Mycobacterium tuberculosis	Conserved protein	0.0107	0.1072	0.0802
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.1316	0.382
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0194	0.0194
Schistosoma mansoni	hypothetical protein	0.0124	0.1261	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0024	0.0089	0.0089
Mycobacterium ulcerans	hypothetical protein	0.0107	0.1072	0.0828
Echinococcus granulosus	cpg binding protein	0.0099	0.0969	0.0969
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1072	0.284
Echinococcus granulosus	beta LACTamase domain containing family member	0.0107	0.1072	0.1072
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.1072	0.1072
Onchocerca volvulus		0.0246	0.27	0.7139
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0413	0.1093
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0302	0.3359	1
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.0042	0.0308	0.0228
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0299	0.332	0.9876
Loa Loa (eye worm)	patched family protein	0.0018	0.0022	0.0058
Echinococcus multilocularis	cpg binding protein	0.0099	0.0969	0.0969
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0608	0.1568
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0057	0.0479	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0058
Onchocerca volvulus		0.0107	0.1072	0.2798
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0068	0.0608	0.0608
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0057	0.0479	0.1171
Brugia malayi	Patched family protein	0.0018	0.0022	0.0058
Echinococcus granulosus	microtubule associated protein 2	0.0711	0.8164	0.8164
Schistosoma mansoni	zinc finger protein	0.0025	0.0107	0.0107
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0437	0.0437
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0028	0.0143	0.0143
Mycobacterium tuberculosis	Conserved protein	0.0107	0.1072	0.0802
Toxoplasma gondii	exonuclease III APE	0.0057	0.0479	0.06
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0308	0.0817
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0068	0.0608	0.1612
Brugia malayi	Pre-SET motif family protein	0.0033	0.0194	0.0514
Echinococcus multilocularis	expressed conserved protein	0.028	0.3107	0.3107

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL556062

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1576992