Detailed information for compound 15965

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 554.505 | Formula: C29H35IN2O
  • H donors: 1 H acceptors: 0 LogP: 6.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1CN[C@H]1C2CC[N+]([C@H]1C(c1ccccc1)c1ccccc1)(CC2)C.[I-]
  • InChi: 1S/C29H35N2O.HI/c1-31-19-17-24(18-20-31)28(30-21-25-15-9-10-16-26(25)32-2)29(31)27(22-11-5-3-6-12-22)23-13-7-4-8-14-23;/h3-16,24,27-30H,17-21H2,1-2H3;1H/q+1;/p-1/t24?,28-,29-,31?;/m0./s1
  • InChiKey: OYCLDODSLABJPF-FTQZKJBXSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0092 0.0068
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.4214 0.42
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Leishmania major zinc-binding dehydrogenase-like protein 0.0082 0.0701 0.597
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0592 0.5045
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0092 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0489 0.0488
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.0063 0.0085
Schistosoma mansoni cpg binding protein 0.0029 0.0198 0.0175
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0183 0.1658 0.1639
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.04 0.0335
Leishmania major extracellular receptor, putative 0.0015 0.0063 0.0222
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0082 0.013
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0067 0.009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0311 0.2545
Mycobacterium ulcerans hypothetical protein 0.0071 0.0592 0.0568
Loa Loa (eye worm) hypothetical protein 0.0082 0.0701 0.07
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0129 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0066
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0092 0.0146
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.0063 0.0062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0092 0.0482
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Loa Loa (eye worm) carboxylesterase 0.0011 0.0025 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0067 0.0106
Schistosoma mansoni cpg binding protein 0.0028 0.0183 0.016
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0063 0.0085
Brugia malayi beta-lactamase 0.0071 0.0592 0.0592
Brugia malayi metabotropic glutamate receptor type 2 0.0078 0.0665 0.0665
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0097 0.0097
Mycobacterium ulcerans beta-lactamase 0.0071 0.0592 0.0568
Mycobacterium ulcerans dehydrogenase 0.0129 0.1149 0.1127
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0025 0.0001
Loa Loa (eye worm) inositol-1 0.0037 0.027 0.0269
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0592 0.0568
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0067 0.009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0592 0.0568
Trypanosoma brucei oxidoreductase, putative 0.0129 0.1149 1
Brugia malayi hypothetical protein 0.0015 0.0063 0.0063
Schistosoma mansoni inositol monophosphatase 0.0037 0.027 0.0247
Toxoplasma gondii type I fatty acid synthase 0.0047 0.0367 0.0302
Loa Loa (eye worm) carboxylesterase 0.0065 0.0542 0.0541
Echinococcus granulosus metabotropic glutamate receptor 2 0.0135 0.12 0.1919
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0542 0.0541
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0129 0.1149 0.1127
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0542 0.0734
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.04 0.3252
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0039 0.0125
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0067 0.009
Trichomonas vaginalis esterase, putative 0.0071 0.0592 0.5045
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0067 0.0106
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0097 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0592 0.5045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.027 0.2184
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0311 0.4641
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0063 0.0085
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2086
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0026 0.0168 0.0143
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0041 0.0311 0.031
Echinococcus granulosus tyrosine kinase 0.0015 0.0063 0.01
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Echinococcus granulosus glutamate receptor 2 0.0015 0.0063 0.01
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0592 0.0555
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0067 0.009
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0129 0.1149 0.1127
Brugia malayi hypothetical protein 0.0024 0.0151 0.0151
Brugia malayi Cytochrome P450 family protein 0.0044 0.0335 0.0335
Leishmania major hypothetical protein, conserved 0.0047 0.0367 0.2956
Loa Loa (eye worm) hypothetical protein 0.0026 0.0168 0.0167
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0047 0.0367 0.0343
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0129 0.1149 0.1127
Echinococcus multilocularis dna polymerase eta 0.0019 0.0097 0.013
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0129 0.1149 0.1127
Onchocerca volvulus 0.0071 0.0592 0.0568
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0146 0.1305 0.1305
Loa Loa (eye worm) acyl carrier protein 0.0082 0.0701 0.07
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0063 0.0085
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0129 0.1149 0.1114
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0474 0.0756
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0063 0.01
Leishmania major zinc binding dehydrogenase-like protein 0.0129 0.1149 1
Toxoplasma gondii ABC1 family protein 0.0071 0.0592 0.0528
Loa Loa (eye worm) glutamate receptor 0.0063 0.0521 0.052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0097 0.0522
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.6252 0.6243
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0097 0.0153
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0311 0.2545
Brugia malayi Inositol-1 0.0037 0.027 0.027
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.125 0.125
Onchocerca volvulus 0.0015 0.0063 0.0039
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0129 0.1149 0.1114
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0047 0.0367 0.0497
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0151 0.1011
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0129 0.1149 0.1127
Leishmania major hypothetical protein, conserved 0.0016 0.0067 0.0258
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0129 0.1149 0.1127
Leishmania major DNA polymerase eta, putative 0.0019 0.0097 0.0522
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0097 0.0072
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2086
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0259 0.0259
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0592 0.0945
Schistosoma mansoni acetylcholinesterase 0.0011 0.0025 0.0001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0023 0.0036
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0025 0.0032
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0129 0.1149 0.1127
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0063 0.004
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0097 0.0522
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0129 0.1149 1
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Schistosoma mansoni metabotropic glutamate receptor 0.0078 0.0665 0.0643
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Toxoplasma gondii type I fatty acid synthase, putative 0.0129 0.1149 0.1089
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0474 0.0451
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Onchocerca volvulus Poor gastrulation protein homolog 0.0026 0.0168 0.0143
Onchocerca volvulus 0.0129 0.1149 0.1127
Leishmania major d-xylulose reductase, putative 0.0129 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0082 0.011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0542 0.0519
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0092 0.0482
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0067 0.0044
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0489 0.078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0151 0.015
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0592 0.0568
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0592 0.0803
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0025 0.0001
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0542 0.0734
Brugia malayi beta-lactamase family protein 0.0071 0.0592 0.0592
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1212 0.1938
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0129 0.1149 0.1127
Schistosoma mansoni tyrosine kinase 0.0015 0.0063 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0067 0.0066
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.04 0.3252
Mycobacterium ulcerans oxidoreductase FadB5 0.0129 0.1149 0.1127
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0367 0.2956
Leishmania major oxidoreductase-like protein 0.0129 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1149 0.1148
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.1061 1 1
Onchocerca volvulus 0.0071 0.0592 0.0568
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0092 0.0473
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0092 0.0068
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.1061 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.027 0.0366
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0092 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0125
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0039 0.006
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0378 0.0355
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0129 0.1149 0.1149
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0592 0.5045
Schistosoma mansoni protein kinase 0.0015 0.0063 0.004
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0039 0.0125
Loa Loa (eye worm) acetyltransferase 0.014 0.125 0.1249
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0039 0.0038
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.027 0.0204
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.027 0.043
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0025 0.0032
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0129 0.1149 0.1127
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0278 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0025 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.0063 0.01
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0592 0.0568
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0001
Brugia malayi jmjC domain containing protein 0.0058 0.0474 0.0474
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0092 0.0456
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.04 0.0399
Mycobacterium ulcerans lipase LipD 0.0071 0.0592 0.0568
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0592 0.057
Brugia malayi beta-lactamase family protein 0.0071 0.0592 0.0592
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0039 0.0051
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0151 0.0986
Onchocerca volvulus 0.0028 0.0183 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0592 0.5045
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0592 0.0568
Onchocerca volvulus 0.0082 0.0701 0.0678
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0097 0.0072
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0592 0.4969
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0082 0.0701 0.0678
Echinococcus granulosus dna polymerase kappa 0.0019 0.0097 0.0153
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0129 0.1149 0.1836
Loa Loa (eye worm) alcohol dehydrogenase class III 0.1061 1 1
Onchocerca volvulus 0.0036 0.0259 0.0235
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0259 0.035
Echinococcus granulosus acetylcholinesterase 0.0065 0.0542 0.0865
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0063 0.0063
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0067 0.0044
Trypanosoma cruzi oxidoreductase, putative 0.0047 0.0367 0.2956
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0151 0.3963
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0023 0.003
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0026 0.0168 0.0145
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0041 0.0311 0.031
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.04 0.3252
Mycobacterium tuberculosis Conserved protein 0.0071 0.0592 0.0568
Mycobacterium ulcerans polyketide synthase 0.0129 0.1149 0.1127
Mycobacterium tuberculosis Conserved protein 0.0071 0.0592 0.0568
Leishmania major DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0335 0.0334
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0129 0.1149 1
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.04 0.0377
Echinococcus multilocularis cpg binding protein 0.0029 0.0198 0.0268
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0063 0.0085
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0063 0.0062
Brugia malayi Carboxylesterase family protein 0.0065 0.0542 0.0542
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0039 0.0125
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0311 0.0245
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.125 0.1229
Schistosoma mansoni DNA polymerase eta 0.0019 0.0097 0.0074
Onchocerca volvulus Putative alcohol dehydrogenase 0.1061 1 1
Mycobacterium ulcerans oxidoreductase 0.0129 0.1149 0.1127
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0063 0.0085
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0039 0.0125
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.027 0.1906
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1149 0.1127
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0067 0.0232
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0151 0.0084
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.027 0.0246
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0039 0.5
Echinococcus multilocularis tyrosine kinase 0.0015 0.0063 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0066
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0129 0.1149 0.1127
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.0063 0.01
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0097 0.0497
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0039 0.0125
Schistosoma mansoni quinone oxidoreductase 0.0047 0.0367 0.0344
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.125 0.1696
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0489 0.0467
Trypanosoma cruzi oxidoreductase, putative 0.0129 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0542 0.0541
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0592 0.4983
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0592 0.0568
Schistosoma mansoni single-minded 0.0048 0.0378 0.0355
Loa Loa (eye worm) carboxylesterase 0.0011 0.0025 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0542 0.0734
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0092 0.0092
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0129 0.1149 0.1127
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0047 0.0367 0.0343
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0097 0.0497
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0233 0.0209
Echinococcus granulosus metabotropic glutamate receptor 5 0.0198 0.1802 0.2881
Mycobacterium tuberculosis Possible dehydrogenase 0.0129 0.1149 0.1127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.04 0.0638
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0092 0.0265
Leishmania major hypothetical protein, conserved 0.0047 0.0367 0.2956
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0067 0.0044
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0015 0.0063 0.0085
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0097 0.0307
Echinococcus multilocularis neuroligin 0.0011 0.0025 0.0032
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0097 0.0497
Brugia malayi PAS domain containing protein 0.0048 0.0378 0.0378
Trypanosoma cruzi quinone oxidoreductase, putative 0.0047 0.0367 0.2956
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Leishmania major nuclear receptor binding factor-like protein 0.0082 0.0701 0.597
Onchocerca volvulus Fatty acid synthase homolog 0.0082 0.0701 0.0678
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0066
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Schistosoma mansoni metabotropic glutamate receptor 0.0135 0.12 0.118
Toxoplasma gondii quinone oxidoreductase, putative 0.0129 0.1149 0.1089
Echinococcus multilocularis geminin 0.0332 0.3071 0.4171
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2086
Loa Loa (eye worm) hypothetical protein 0.0065 0.0542 0.0541
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0701 0.0701
Loa Loa (eye worm) oxidoreductase 0.0047 0.0367 0.0366
Schistosoma mansoni zinc binding dehydrogenase 0.0129 0.1149 0.1128
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0129 0.1149 0.1127
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0233 0.0196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0592 0.057
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.1061 1 1
Schistosoma mansoni gliotactin 0.0011 0.0025 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.6252 0.8494
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0129 0.1149 0.1127
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0067 0.0044
Echinococcus granulosus single minded 2 0.0036 0.0259 0.0412
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.1061 1 1
Brugia malayi MAP kinase sur-1 0.0051 0.04 0.04
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0701 0.597
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0129 0.1149 1
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0129 0.1149 0.1114
Brugia malayi CXXC zinc finger family protein 0.0028 0.0183 0.0183
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0063 0.01
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0129 0.1149 0.1114
Onchocerca volvulus 0.0013 0.0039 0.0014
Loa Loa (eye worm) beta-lactamase 0.0071 0.0592 0.0591
Onchocerca volvulus 0.0015 0.0063 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0592 0.0591
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0092 0.1177
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.04 0.3252
Brugia malayi Carboxylesterase family protein 0.0065 0.0542 0.0542
Echinococcus granulosus phd:f box containing protein 0.0016 0.0067 0.0106
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0701 0.0701
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0067 0.0066
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0932 0.8771 0.8768
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0451 0.0387
Leishmania major quinone oxidoreductase, putative 0.0129 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0097 0.013
Brugia malayi hypothetical protein 0.0016 0.0069 0.0069
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.04 0.0542
Echinococcus multilocularis GPCR, family 3, C terminal 0.0026 0.0168 0.0226
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0542 0.0865
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0063 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0092 0.0482
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0129 0.1149 0.1127
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.04 0.0542
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0039 0.0051
Trypanosoma cruzi oxidoreductase, putative 0.0129 0.1149 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0063 0.0062
Schistosoma mansoni ap endonuclease 0.0018 0.0092 0.0069
Schistosoma mansoni tyrosine kinase 0.0015 0.0063 0.004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0039 0.0125
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0067 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0592 0.4983
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Schistosoma mansoni hypothetical protein 0.0332 0.3071 0.3055
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0278 0.1979
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0097 0.0074
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.04 0.3252
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0592 1
Trypanosoma cruzi quinone oxidoreductase, putative 0.0047 0.0367 0.2956
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0129 0.1149 0.1148
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0015 0.0063 0.0039
Mycobacterium leprae Probable oxidireductase 0.0129 0.1149 0.1114
Loa Loa (eye worm) hypothetical protein 0.0198 0.1802 0.1801
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.027 0.2184
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0097 0.013
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0151 0.1593
Brugia malayi Metabotropic glutamate receptor precursor. 0.0161 0.1448 0.1448
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.04 0.0638
Echinococcus granulosus microtubule associated protein 2 0.0667 0.6252 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0151 0.1011
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0025 0.0032
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0039 0.0125
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0129 0.1149 0.1559
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Schistosoma mansoni cpg binding protein 0.0029 0.0198 0.0175
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0592 0.0568
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Mycobacterium ulcerans quinone reductase Qor 0.0129 0.1149 0.1127
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.027 0.2184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0092 0.06
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0129 0.1149 0.1127
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0129 0.1149 0.1127
Mycobacterium ulcerans short-chain dehydrogenase 0.0129 0.1149 0.1127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0067 0.0066
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0129 0.1149 1
Schistosoma mansoni alcohol dehydrogenase 0.1061 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0063 0.0062
Trypanosoma brucei unspecified product 0.0019 0.0097 0.0497
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Mycobacterium leprae Probable lipase LipE 0.0071 0.0592 0.0555
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0097 0.0097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0092 0.0091
Mycobacterium leprae Probable polyketide synthase Pks1 0.0129 0.1149 0.1114
Trypanosoma cruzi extracellular receptor, putative 0.0015 0.0063 0.0222
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0311 0.0311
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.1061 1 1
Echinococcus granulosus glutamate receptor 2 0.0015 0.0063 0.01
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0038
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0311 0.0245
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0129 0.1149 0.1127
Mycobacterium tuberculosis Conserved protein 0.0071 0.0592 0.0568
Leishmania major oxidoreductase, putative 0.0129 0.1149 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0592 0.5045
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.0063 0.0085
Brugia malayi jmjC domain containing protein 0.006 0.0489 0.0489
Echinococcus granulosus dna polymerase eta 0.0019 0.0097 0.0153
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.736 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Mycobacterium tuberculosis Possible dehydrogenase 0.0129 0.1149 0.1127
Echinococcus granulosus GPCR family 3 C terminal 0.0026 0.0168 0.0267
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.0063 0.0063
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0039 0.0125
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0135 0.12 0.163
Leishmania major protein kinase, putative 0.0013 0.0043 0.0039
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0097 0.0641
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0025 0.0038
Giardia lamblia DINP protein human, muc B family 0.0019 0.0097 0.0147
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0047 0.0367 0.2937
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0097 0.0497
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0097 0.0072
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0063 0.0085
Leishmania major hypothetical protein, conserved 0.0024 0.0151 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0125
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0129 0.1149 0.1127
Trypanosoma brucei oxidoreductase, putative 0.0129 0.1149 1
Brugia malayi hypoxia-induced factor 1 0.0149 0.1338 0.1338
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0932 0.8771 0.8768
Echinococcus granulosus geminin 0.0332 0.3071 0.4911
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0047 0.0367 0.0585
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0129 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Leishmania major hypothetical protein, conserved 0.0071 0.0592 0.4983
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.1338 0.1337
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.04 0.3234
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0592 0.0592
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.1061 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0125
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0311 0.0495
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.04 0.3252
Schistosoma mansoni ap endonuclease 0.0018 0.0092 0.0069
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0259 0.0235
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0001
Schistosoma mansoni inositol monophosphatase 0.0037 0.027 0.0247
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0129 0.1149 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0198 0.1802 0.2447
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0129 0.1149 1
Echinococcus granulosus acetylcholinesterase 0.0065 0.0542 0.0865
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0367 0.0367
Echinococcus granulosus cpg binding protein 0.0029 0.0198 0.0315
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0592 0.0568
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Toxoplasma gondii exonuclease III APE 0.0018 0.0092 0.0025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0097 0.0072
Brugia malayi hypothetical protein 0.0011 0.0025 0.0025
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0129 0.1149 0.1149
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0129 0.1149 0.1127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Onchocerca volvulus 0.0071 0.0592 0.0568
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0063 0.01
Mycobacterium ulcerans quinone oxidoreductase 0.0129 0.1149 0.1127
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0067 0.0044
Schistosoma mansoni hypothetical protein 0.0332 0.3071 0.3055
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0039 0.006
Brugia malayi hypothetical protein 0.0162 0.1457 0.1457
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.1061 1 1
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0025 0.0038
Mycobacterium ulcerans oxidoreductase 0.0047 0.0367 0.0343
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0151 0.3963
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0478 0.0456
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0047 0.0367 0.2956
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2064
Echinococcus granulosus neuroligin 0.0011 0.0025 0.0038
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0474 0.0642
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.1061 1 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0015 0.0063 0.01
Loa Loa (eye worm) hypothetical protein 0.0129 0.1149 0.1148
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0592 0.0568
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Trypanosoma brucei protein kinase, putative 0.0051 0.04 0.3234
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0129 0.1149 0.1127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0092 0.0124
Mycobacterium ulcerans quinone oxidoreductase 0.0129 0.1149 0.1127
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0082 0.0701 0.5959
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0129 0.1149 0.1127
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0474 0.0642
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0097 0.0074
Mycobacterium ulcerans oxidoreductase 0.0082 0.0701 0.0678
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Leishmania major protein kinase, putative 0.0013 0.0043 0.0039
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0063 0.0063
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0162 0.1457 0.1456
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0097 0.0641
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0278 0.6047
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.027 0.1685
Loa Loa (eye worm) hypothetical protein 0.0041 0.0311 0.031
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0129 0.1149 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0067 0.0258
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0067 0.0258
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0489 0.0467
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0183 0.0182
Loa Loa (eye worm) glutamate receptor 0.0161 0.1448 0.1448
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0129 0.1149 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12.2 nM Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]-Bolton-Hunter substance p from human IM-9 cells ChEMBL. No reference
IC50 (binding) = 12.2 nM Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]-Bolton-Hunter substance p from human IM-9 cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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