TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 680.836 | Formula: C39H48N6O5
H donors: 4 H acceptors: 4 LogP: 4.27 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: NCCCOCC1=C(C(=O)NCCCN2CCC(CC2)(c2ccccc2)c2ccccc2)C(C(=C(N1)CC)C(=O)N)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C39H48N6O5/c1-2-32-35(37(41)46)34(28-15-17-31(18-16-28)45(48)49)36(33(43-32)27-50-26-9-21-40)38(47)42-22-10-23-44-24-19-39(20-25-44,29-11-5-3-6-12-29)30-13-7-4-8-14-30/h3-8,11-18,34,43H,2,9-10,19-27,40H2,1H3,(H2,41,46)(H,42,47)
InChiKey: GHMHLQOFXXKCPZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adrenoceptor alpha 1B	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 2C	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 2A	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 2B	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 1A	Starlite/ChEMBL	References
Homo sapiens	adrenoceptor alpha 1D	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	amine GPCR	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma japonicum	Alpha-1D adrenergic receptor, putative	Get druggable targets OG5_128924	All targets in OG5_128924

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0024	0.009	0.0023
Onchocerca volvulus		0.006	0.055	0.1699
Brugia malayi	G-protein coupled receptor	0.0057	0.0517	0.0485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0517	0.0474
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0057	0.0517	0.1578
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Loa Loa (eye worm)	CUTiclin family member	0.0035	0.0231	0.0175
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.009	0.0021
Brugia malayi	hypothetical protein	0.0035	0.0231	0.0175
Loa Loa (eye worm)	CUTiclin-Like family member	0.0035	0.0231	0.0175
Brugia malayi	Steroid receptor seven-up type 2	0.0024	0.009	0.0023
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0517	0.0474
Onchocerca volvulus		0.0057	0.0517	0.1578
Trypanosoma brucei	beta tubulin	0.0022	0.0069	0.0169
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0517	0.0451
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Echinococcus granulosus	hypothetical protein	0.0057	0.0517	0.0474
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0517	0.0451
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0517	0.0451
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0517	0.0485
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0517	0.0474
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0035	0.0231	0.0171
Echinococcus granulosus	Furin 1	0.0178	0.2036	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0024	0.009	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	growth hormone secretagogue receptor	0.0057	0.0517	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.009	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Schistosoma mansoni	histamine h1 receptor	0.0057	0.0517	0.0474
Plasmodium vivax	von Willebrand factor A domain-related protein, putative	0.0035	0.0231	0.2733
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0517	0.0474
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0024	0.009	0.0023
Onchocerca volvulus		0.0238	0.2796	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0057	0.0517	0.0485
Echinococcus multilocularis	g-protein coupled receptor	0.0057	0.0517	0.0451
Brugia malayi	proprotein convertase 2	0.0472	0.5764	0.6172
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	collagen alpha 1(VII) chain	0.0035	0.0231	0.0163
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0308	0.0753
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.077	0.9523	0.952
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0024	0.009	0.0022
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0517	0.0474
Brugia malayi	Zona pellucida-like domain containing protein	0.0035	0.0231	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Brugia malayi	Zona pellucida-like domain containing protein	0.0035	0.0231	0.0175
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0517	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0024	0.009	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0517	0.0474
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0517	0.0474
Treponema pallidum	76K protein	0.0035	0.0231	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0517	0.0474
Schistosoma mansoni	amine GPCR	0.0057	0.0517	0.0474
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0517	0.0474
Echinococcus granulosus	7TM GPCR rhodopsin	0.0057	0.0517	0.0474
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0057	0.0517	0.0451
Schistosoma mansoni	hypothetical protein	0.0035	0.0231	0.0171
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0057	0.0517	0.0485
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0517	0.0451
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0024	0.009	0.0023
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0457	0.5568	0.5537
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0517	0.0485
Trypanosoma cruzi	subtilisin peptidase	0.0032	0.0198	0.5368
Giardia lamblia	Beta tubulin	0.0022	0.0069	0.0039
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0086	0.0877	0.0813
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0149	0.1675	0.1617
Loa Loa (eye worm)	endoprotease bli-4	0.0752	0.9296	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0443	0.0405
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0096	0.1002	0.0987
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0032	0.0198	0.0139
Onchocerca volvulus		0.0057	0.0517	0.1578
Echinococcus granulosus	serotonin receptor	0.0057	0.0517	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0517	0.0451
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0096	0.1002	0.0939
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0057	0.0517	0.0451
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0035	0.0231	0.0171
Echinococcus multilocularis	dro:myosuppressin receptor	0.0057	0.0517	0.0451
Plasmodium vivax	subtilisin-like serine protease, putative	0.0032	0.0198	0.2166
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus multilocularis	neuropeptide receptor A26	0.0057	0.0517	0.0451
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0024	0.009	0.0022
Onchocerca volvulus		0.0209	0.2428	0.8638
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0024	0.009	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0032	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Plasmodium falciparum	apical sushi protein	0.006	0.055	0.8114
Echinococcus multilocularis	neuropeptides capa receptor	0.0057	0.0517	0.0451
Brugia malayi	Will die slowly protein	0.0209	0.2428	0.2556
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0024	0.009	0.0022
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0517	0.0474
Brugia malayi	polk-prov protein	0.0031	0.0183	0.0123
Echinococcus granulosus	neuropeptide s receptor	0.0057	0.0517	0.0474
Onchocerca volvulus		0.0035	0.0231	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0057	0.0517	0.0451
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Toxoplasma gondii	subtilisin SUB5	0.0032	0.0198	0.2166
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	amine GPCR	0.0057	0.0517	0.0474
Loa Loa (eye worm)	neuropeptide F receptor	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	FTZ F1 alpha	0.0024	0.009	0.0021
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0308	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0057	0.0517	0.0485
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0517	0.0474
Echinococcus multilocularis		0.0606	0.7458	0.744
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0057	0.0517	0.0451
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0752	0.9296	0.976
Onchocerca volvulus		0.006	0.055	0.1699
Entamoeba histolytica	hypothetical protein, conserved	0.0035	0.0231	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Schistosoma mansoni	hypothetical protein	0.0057	0.0517	0.0474
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0069	0.0662	0.0627
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0517	0.0474
Schistosoma mansoni	amine GPCR	0.0057	0.0517	0.0474
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Toxoplasma gondii	subtilisin SUB12	0.0032	0.0198	0.2166
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0057	0.0517	0.0474
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0231	0.2733
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0096	0.1002	0.1011
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0397	0.0347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0024	0.009	0.0023
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Brugia malayi	nuclear hormone receptor	0.0024	0.009	0.0023
Plasmodium falciparum	subtilisin-like protease 3	0.0032	0.0198	0.2166
Echinococcus granulosus	biogenic amine 5HT receptor	0.0057	0.0517	0.0474
Onchocerca volvulus		0.006	0.055	0.1699
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.009	0.0021
Schistosoma mansoni	hypothetical protein	0.0048	0.0397	0.0347
Loa Loa (eye worm)	steroid hormone receptor	0.0024	0.009	0.0023
Brugia malayi	hypothetical protein	0.006	0.055	0.0521
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Onchocerca volvulus		0.0035	0.0231	0.0521
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Brugia malayi	hypothetical protein	0.006	0.055	0.0521
Trypanosoma brucei	DNA polymerase IV, putative	0.0041	0.0308	0.0753
Onchocerca volvulus		0.0035	0.0231	0.0521
Onchocerca volvulus		0.0057	0.0517	0.1578
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0183	0.0446
Toxoplasma gondii	rhoptry neck protein RON1	0.006	0.055	0.8114
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0178	0.2036	0.3577
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0517	0.0474
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0035	0.0231	0.0163
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0198	0.0233
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0032	0.0198	0.0129
Echinococcus multilocularis	dna polymerase kappa	0.0041	0.0308	0.0241
Echinococcus granulosus	ecdysone induced protein 78C	0.0024	0.009	0.0022
Onchocerca volvulus		0.0035	0.0231	0.0521
Entamoeba histolytica	elongation factor-2 kinase, putative	0.0035	0.0231	1
Onchocerca volvulus		0.0057	0.0517	0.1578
Echinococcus granulosus	somatostatin receptor	0.0057	0.0517	0.0474
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0517	0.0474
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0057	0.0517	0.0474
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0032	0.0198	0.5368
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0198	0.0233
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Toxoplasma gondii	subtilisin SUB2	0.0032	0.0198	0.2166
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0069	0.0662	0.0597
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0057	0.0517	0.0451
Plasmodium vivax	subtilisin-like protease 1	0.0032	0.0198	0.2166
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0024	0.009	0.0021
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0308	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0195	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Echinococcus multilocularis	sex peptide receptor	0.0057	0.0517	0.0451
Trypanosoma brucei	beta tubulin	0.0022	0.0069	0.0169
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Brugia malayi	putative neuropeptide receptor NPR1	0.0057	0.0517	0.0485
Echinococcus granulosus	tm gpcr rhodopsin	0.0057	0.0517	0.0474
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0032	0.0198	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0031	0.0183	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Plasmodium vivax	dynein-related AAA-type ATPase, putative	0.0035	0.0231	0.2733
Brugia malayi	RE15519p	0.0057	0.0517	0.0485
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0517	0.0451
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0057	0.0517	0.1578
Toxoplasma gondii	subtilisin SUB6	0.0032	0.0198	0.2166
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0024	0.009	0.0023
Echinococcus granulosus	FTZ F1 alpha	0.0024	0.009	0.0022
Giardia lamblia	Beta tubulin	0.0022	0.0069	0.0039
Brugia malayi	GnHR receptor homolog	0.0057	0.0517	0.0485
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0057	0.0517	0.0474
Brugia malayi	AKH receptor	0.0057	0.0517	0.0485
Plasmodium vivax	subtilisin-like protease 2, putative	0.0032	0.0198	0.2166
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0035	0.0231	0.0294
Onchocerca volvulus		0.0057	0.0517	0.1578
Echinococcus granulosus	orexin receptor type 2	0.0057	0.0517	0.0474
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Onchocerca volvulus		0.0057	0.0517	0.1578
Trichomonas vaginalis	hypothetical protein	0.0145	0.163	0.2838
Brugia malayi	hypothetical protein	0.006	0.055	0.0521
Brugia malayi	Dopamine receptor protein 2	0.0057	0.0517	0.0485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0178	0.2036	0.3577
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0457	0.5568	1
Schistosoma mansoni	furin-1 (S08 family)	0.0327	0.3926	0.4079
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0057	0.0517	0.0485
Schistosoma mansoni	neuropeptide F-like receptor	0.0057	0.0517	0.0474
Schistosoma mansoni	RAR-like nuclear receptor	0.0024	0.009	0.0022
Onchocerca volvulus		0.0048	0.0397	0.1135
Brugia malayi	hypothetical protein	0.006	0.055	0.0521
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0024	0.009	0.0022
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0517	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Onchocerca volvulus		0.0057	0.0517	0.1578
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0057	0.0517	0.0451
Onchocerca volvulus		0.006	0.055	0.1699
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Echinococcus multilocularis	ecdysone induced protein 78C	0.0024	0.009	0.0021
Brugia malayi	Sushi domain	0.006	0.055	0.0521
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0032	0.0198	0.0483
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0086	0.0877	0.0854
Onchocerca volvulus		0.006	0.055	0.1699
Onchocerca volvulus		0.0032	0.0195	0.0388
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0032	0.0198	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	opsin-like receptor	0.0057	0.0517	0.0474
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0057	0.0517	0.0485
Echinococcus multilocularis	neuropeptide s receptor	0.0057	0.0517	0.0451
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0397	0.0356
Leishmania major	subtilisin-like serine peptidase	0.0032	0.0198	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0237	0.0181
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.006	0.055	0.0521
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0057	0.0517	0.0474
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0024	0.009	0.0021
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0032	0.0198	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0057	0.0517	0.0474
Brugia malayi	neuroendocrine convertase 1 precursor	0.0472	0.5764	0.6172
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0041	0.0308	0.0435
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0517	0.0451
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.2435	0.2564
Schistosoma mansoni	opsin-like receptor	0.0057	0.0517	0.0474
Toxoplasma gondii	von Willebrand factor type A domain-containing protein	0.0035	0.0231	0.2733
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0195	0.0136
Echinococcus multilocularis	somatostatin receptor	0.0057	0.0517	0.0451
Onchocerca volvulus		0.0057	0.0517	0.1578
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0032	0.0198	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	hypothetical protein	0.0035	0.0237	0.0177
Trypanosoma brucei	beta tubulin	0.0022	0.0069	0.0169
Echinococcus multilocularis	G protein coupled receptor 139	0.0057	0.0517	0.0451
Brugia malayi	celfurPC protein	0.0606	0.7458	0.8007
Trypanosoma brucei	RNA helicase, putative	0.034	0.4091	1
Echinococcus multilocularis	Furin 1	0.0178	0.2036	0.1981
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0057	0.0517	0.0451
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Plasmodium vivax	circumsporozoite- and TRAP-related protein, putative	0.0035	0.0231	0.2733
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0057	0.0517	0.0474
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	subtilase	0.0032	0.0198	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Echinococcus granulosus	neuroendocrine convertase 2	0.0472	0.5764	0.6024
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0057	0.0517	0.0474
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0024	0.009	0.0022
Brugia malayi	GCC2 and GCC3 family protein	0.006	0.055	0.0521
Brugia malayi	ORL1-like opioid receptor	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Echinococcus granulosus	7tm_1 domain containing protein	0.0057	0.0517	0.0474
Echinococcus granulosus	membrane bound transcription factor site 1	0.0032	0.0198	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0457	0.5568	1
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0517	0.0474
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Trypanosoma brucei	subtilisin peptidase	0.0032	0.0198	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0443	0.0405
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0198	0.0233
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Onchocerca volvulus		0.006	0.055	0.1699
Brugia malayi	nuclear receptor NHR-88	0.0024	0.009	0.0023
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0308	1
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Toxoplasma gondii	subtilisin SUB7	0.0032	0.0198	0.2166
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0024	0.009	0.0021
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0024	0.009	0.0022
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.2763	0.2712
Schistosoma mansoni	adenoreceptor	0.0057	0.0517	0.0474
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0069	0.0662	1
Treponema pallidum	hypothetical protein	0.0035	0.0231	0.5
Onchocerca volvulus		0.0057	0.0517	0.1578
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0235	0.2763	0.2919
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Plasmodium vivax	apical sushi protein, putative	0.006	0.055	0.8114
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0517	0.0474
Onchocerca volvulus		0.006	0.055	0.1699
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0057	0.0517	0.0474
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Brugia malayi	putative neuropeptide receptor	0.0057	0.0517	0.0485
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.1675	0.1699
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0057	0.0517	0.0451
Brugia malayi	hypothetical protein	0.006	0.055	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Loa Loa (eye worm)	von Willebrand factor type A domain-containing protein	0.0035	0.0231	0.0175
Plasmodium falciparum	subtilisin-like protease 2	0.0032	0.0198	0.2166
Onchocerca volvulus		0.0035	0.0231	0.0521
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Onchocerca volvulus		0.0057	0.0517	0.1578
Trichomonas vaginalis	DNA polymerase eta, putative	0.0041	0.0308	0.0435
Brugia malayi	neuropeptide F receptor	0.0057	0.0517	0.0485
Toxoplasma gondii	rhoptry neck protein RON9	0.006	0.055	0.8114
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0035	0.0231	0.0175
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0145	0.163	0.2838
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0308	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0195	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Onchocerca volvulus		0.0057	0.0517	0.1578
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.2763	0.2849
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0024	0.009	0.0023
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0041	0.0308	1
Plasmodium vivax	SET domain protein, putative	0.0032	0.0195	0.2125
Echinococcus multilocularis	C type lectin domian containing protein	0.006	0.055	0.0484
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0195	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Echinococcus multilocularis	neuroendocrine convertase 2	0.0472	0.5764	0.5735
Echinococcus multilocularis	allatostatin A receptor	0.0057	0.0517	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0517	0.0474
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Echinococcus granulosus	furin	0.0752	0.9296	0.976
Echinococcus granulosus	neuropeptide FF receptor 2	0.0057	0.0517	0.0474
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0032	0.0198	0.5368
Echinococcus granulosus	dna polymerase kappa	0.0041	0.0308	0.0253
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Schistosoma mansoni	neuropeptide f receptor 76f	0.0057	0.0517	0.0474
Echinococcus granulosus	g-protein coupled receptor	0.0057	0.0517	0.0474
Brugia malayi	steroid hormone receptor	0.0024	0.009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	serotonin receptor	0.0057	0.0517	0.0451
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0517	0.0474
Brugia malayi	follicle stimulating hormone receptor	0.0057	0.0517	0.0485
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Brugia malayi	Protein set-1	0.0069	0.0662	0.0642
Schistosoma mansoni	coup transcription factor	0.0024	0.009	0.0022
Brugia malayi	hypothetical protein	0.006	0.055	0.0521
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0153	0.0088
Echinococcus granulosus	G protein coupled receptor 139	0.0057	0.0517	0.0474
Mycobacterium ulcerans	DNA polymerase IV	0.0041	0.0308	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0517	0.0474
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0145	0.163	0.2838
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0178	0.2036	0.2081
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0069	0.0662	0.0627
Schistosoma mansoni	myosin xvIII	0.0057	0.0517	0.0474
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0024	0.009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0183	0.0123
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.009	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0024	0.009	0.0023
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0057	0.0517	0.0474
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0032	0.0198	0.0136
Plasmodium vivax	thrombospondin-related anonymous protein	0.0035	0.0231	0.2733
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.009	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0057	0.0517	0.0474
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0057	0.0517	0.0474
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0457	0.5568	0.5817
Echinococcus multilocularis	neuropeptide Y receptor	0.0057	0.0517	0.0451
Toxoplasma gondii	subtilisin SUB10	0.0032	0.0198	0.2166
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0057	0.0517	0.0474
Plasmodium falciparum	subtilisin-like protease 1	0.0032	0.0198	0.2166
Echinococcus multilocularis	protein will die slowly	0.0209	0.2428	0.2375
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0057	0.0517	0.0474
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0057	0.0517	0.0474
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0057	0.0517	0.0474
Onchocerca volvulus		0.0032	0.0198	0.0397
Brugia malayi	Serotonin receptor	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0443	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus granulosus	neuropeptide receptor	0.0057	0.0517	0.0474
Schistosoma mansoni	hypothetical protein	0.034	0.4091	0.4255
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0024	0.009	0.0021
Schistosoma mansoni	retinoic acid receptor RXR	0.0024	0.009	0.0022
Loa Loa (eye worm)	von Willebrand factor domain-containing protein	0.0035	0.0231	0.0175
Brugia malayi	hypothetical protein	0.006	0.055	0.0521
Toxoplasma gondii	microneme protein MIC2	0.0035	0.0231	0.2733
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.009	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Schistosoma mansoni	hypothetical protein	0.0057	0.0517	0.0474
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0032	0.0198	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.2796	0.496
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.009	0.0023
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0057	0.0517	0.0451
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.1376	0.1316
Brugia malayi	hypothetical protein	0.0235	0.2763	0.2919
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0057	0.0138
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.077	0.9523	1
Onchocerca volvulus		0.0035	0.0231	0.0521
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0517	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Trichomonas vaginalis	WD repeat domain, putative	0.0209	0.2428	0.4289
Mycobacterium leprae	Possible secreted protease	0.0032	0.0198	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0198	0.0233
Entamoeba histolytica	hypothetical protein, conserved	0.0035	0.0231	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0024	0.009	0.0023
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0032	0.0198	1
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0032	0.0198	0.0136
Echinococcus multilocularis	fmrfamide receptor	0.0057	0.0517	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	amine GPCR	0.0057	0.0517	0.0474
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0032	0.0198	0.0136
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0517	0.0451
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.009	0.0023
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0032	0.0198	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0195	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0024	0.009	0.0022
Plasmodium falciparum	von Willebrand factor A domain-related protein	0.0035	0.0231	0.2733
Onchocerca volvulus		0.006	0.055	0.1699
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Toxoplasma gondii	subtilisin SUB1	0.0032	0.0198	0.2166
Echinococcus granulosus	sex peptide receptor	0.0057	0.0517	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.0023
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0057	0.0517	0.0474
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Brugia malayi	Melatonin receptor type 1A	0.0057	0.0517	0.0485
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0517	0.0474
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0024	0.009	0.0022
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0057	0.0517	0.0451
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0024	0.009	0.0023
Brugia malayi	G protein-coupled receptor F59B2.13	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Brugia malayi	G protein-coupled receptor	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Giardia lamblia	Furin precursor putative serine protease	0.0145	0.163	0.4816
Brugia malayi	Dopamine receptor	0.0057	0.0517	0.0485
Echinococcus granulosus	fmrfamide receptor	0.0057	0.0517	0.0474
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.006	0.055	0.0521
Brugia malayi	Serotonin receptor	0.0057	0.0517	0.0485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0517	0.0474
Brugia malayi	Subtilase family protein	0.0032	0.0198	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0024	0.009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0032	0.0198	1
Toxoplasma gondii	subtilisin SUB4	0.0032	0.0198	0.2166
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0057	0.0517	0.0485
Trypanosoma brucei	DNA polymerase kappa, putative	0.0041	0.0308	0.0753
Loa Loa (eye worm)	TYRA-2 protein	0.0057	0.0517	0.0485
Brugia malayi	photoreceptor-specific nuclear receptor	0.0024	0.009	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0662	0.0642
Trypanosoma brucei	unspecified product	0.0034	0.0225	0.055
Schistosoma mansoni	amine GPCR	0.0457	0.5574	0.5823
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Schistosoma mansoni	hypothetical protein	0.0057	0.0517	0.0474
Onchocerca volvulus		0.0057	0.0517	0.1578
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0178	0.2036	0.3577
Schistosoma mansoni	hypothetical protein	0.0125	0.1376	0.1382
Onchocerca volvulus		0.006	0.055	0.1699
Echinococcus multilocularis	neuropeptide receptor	0.0057	0.0517	0.0451
Schistosoma mansoni	c4b-binding protein beta chain	0.006	0.055	0.0509
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Brugia malayi	larval opioid receptor	0.0057	0.0517	0.0485
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0517	0.0474
Toxoplasma gondii	subtilisin SUB8	0.0032	0.0198	0.2166
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0024	0.009	0.0022
Echinococcus granulosus	protein will die slowly	0.0209	0.2428	0.2495
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0057	0.0517	0.0451
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0195	0.0127
Entamoeba histolytica	hypothetical protein	0.0035	0.0231	1
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Onchocerca volvulus		0.0057	0.0517	0.1578
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Brugia malayi	Dopamine receptor protein 1	0.0057	0.0517	0.0485
Toxoplasma gondii	subtilisin SUB9	0.0032	0.0198	0.2166
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0195	0.0133
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Schistosoma mansoni	opsin-like receptor	0.0057	0.0517	0.0474
Plasmodium falciparum	thrombospondin-related anonymous protein	0.0035	0.0231	0.2733
Brugia malayi	G-protein coupled receptor	0.0057	0.0517	0.0485
Echinococcus multilocularis	g protein coupled receptor	0.0057	0.0517	0.0451
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0517	0.0474
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0517	0.0474
Echinococcus granulosus	g protein coupled receptor	0.0057	0.0517	0.0474
Echinococcus granulosus	neuropeptide Y receptor	0.0057	0.0517	0.0474
Plasmodium falciparum	SET domain protein, putative	0.0069	0.0662	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0035	0.0231	0.0175
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.1675	0.1699
Giardia lamblia	High cysteine membrane protein Group 2	0.0279	0.3323	1
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Brugia malayi	sulfakinin receptor protein	0.0057	0.0517	0.0485
Onchocerca volvulus		0.006	0.055	0.1699
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0057	0.0517	0.0474
Loa Loa (eye worm)	proprotein convertase 2	0.0178	0.2036	0.2132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0024	0.009	0.0023
Echinococcus multilocularis	orexin receptor type 2	0.0057	0.0517	0.0451
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.009	0.0023
Brugia malayi	neuropeptide F receptor	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus multilocularis	serotonin receptor	0.0057	0.0517	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Onchocerca volvulus		0.0057	0.0517	0.1578
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.009	0.0023
Loa Loa (eye worm)	G-protein coupled receptor	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0198	0.0139
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0178	0.2036	0.3577
Brugia malayi	endoprotease bli-4 precursor	0.0752	0.9296	1
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Schistosoma mansoni	biogenic amine receptor	0.0057	0.0517	0.0474
Giardia lamblia	Beta tubulin	0.0022	0.0069	0.0039
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Onchocerca volvulus		0.0057	0.0517	0.1578
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Echinococcus granulosus	C type lectin domian containing protein	0.006	0.055	0.0509
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.009	0.0023
Trypanosoma brucei	beta tubulin	0.0022	0.0069	0.0169
Echinococcus multilocularis	c4b binding protein beta chain	0.006	0.055	0.0484
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0443	0.0405
Brugia malayi	hypothetical protein	0.0057	0.0517	0.0485
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0231	0.0175
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.009	0.0022
Brugia malayi	pregnancy-associated plasma protein-A	0.006	0.055	0.0521
Schistosoma mansoni	hypothetical protein	0.0035	0.0231	0.0171
Schistosoma mansoni	hypothetical protein	0.0209	0.2428	0.2495
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Echinococcus granulosus	dro:myosuppressin receptor	0.0057	0.0517	0.0474
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0237	0.0181
Schistosoma mansoni	neuropeptide receptor	0.0057	0.0517	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Brugia malayi	Pre-SET motif family protein	0.0209	0.2435	0.2564
Plasmodium vivax	SET domain protein, putative	0.0069	0.0662	1
Brugia malayi	ecdysteroid receptor	0.0024	0.009	0.0023
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0295	0.352	0.3739
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.1376	0.1382
Schistosoma mansoni	hypothetical protein	0.0057	0.0517	0.0474
Schistosoma mansoni	hypothetical protein	0.0145	0.163	0.1651
Echinococcus granulosus	c4b binding protein beta chain	0.006	0.055	0.0509
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0225	0.055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0024	0.009	0.0023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0057	0.0517	0.0474
Leishmania major	beta tubulin	0.0022	0.0069	0.0897
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0032	0.0198	0.0233
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0032	0.0198	0.0129
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0057	0.0517	0.0485
Onchocerca volvulus		0.0057	0.0517	0.1578
Loa Loa (eye worm)	WD40 repeat protein	0.0209	0.2428	0.2556
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0057	0.0517	0.0451
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0057	0.0517	0.0474
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0057	0.0517	0.0485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0178	0.2036	0.3577
Loa Loa (eye worm)	hypothetical protein	0.0752	0.9296	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.077	0.9523	1
Brugia malayi	von Willebrand Factor	0.0035	0.0231	0.0175
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0178	0.2036	0.3577
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.163	0.2838
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Echinococcus granulosus	collagen alpha 1VII chain	0.0035	0.0231	0.0171
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0032	0.0198	0.5368
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.1002	0.0987
Onchocerca volvulus		0.0057	0.0517	0.1578
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0057	0.0517	0.0474
Brugia malayi	Pre-SET motif family protein	0.0032	0.0195	0.0136
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.1002	0.0987
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0195	0.2125
Echinococcus granulosus	neuropeptide receptor A26	0.0057	0.0517	0.0474
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0145	0.163	0.2838
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0517	0.0485
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0057	0.0517	0.0485
Echinococcus granulosus	allatostatin A receptor	0.0057	0.0517	0.0474
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0195	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0198	0.0233
Plasmodium falciparum	circumsporozoite- and TRAP-related protein	0.0035	0.0231	0.2733
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0231	0.0175
Toxoplasma gondii	subtilisin SUB11	0.0032	0.0198	0.2166
Echinococcus granulosus	neuropeptides capa receptor	0.0057	0.0517	0.0474
Onchocerca volvulus		0.0035	0.0231	0.0521

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 4.8 nM	Binding affinity against human Alpha-1a adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 4.8 nM	Binding affinity against human Alpha-1a adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 286 nM	Binding affinity against human Alpha-2c adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 286 nM	Binding affinity against human Alpha-2c adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 447 nM	Binding affinity against human Alpha-1b adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 447 nM	Binding affinity against human Alpha-1b adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 813 nM	Binding affinity against human Alpha-2a adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 813 nM	Binding affinity against human Alpha-2a adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 948 nM	Binding affinity against human Alpha-1d adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 948 nM	Binding affinity against human Alpha-1d adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 1131 nM	Binding affinity against human Alpha-2b adrenergic receptor	ChEMBL.	10522703
Ki (binding)	= 1131 nM	Binding affinity against human Alpha-2b adrenergic receptor	ChEMBL.	10522703
Ratio (binding)	> 60	Ratio of binding affinity against human alpha 1d-adrenoceptor by human alpha 1a-adrenoceptor	ChEMBL.	10522703
Ratio (binding)	> 60	Ratio of binding affinity against human alpha 1b-adrenoceptor by human alpha 1a-adrenoceptor	ChEMBL.	10522703
Ratio (binding)	> 60	Ratio of binding affinity against human alpha 1d-adrenoceptor by human alpha 1a-adrenoceptor	ChEMBL.	10522703
Ratio (binding)	> 60	Ratio of binding affinity against human alpha 2a-adrenoceptor by human alpha 1a-adrenoceptor	ChEMBL.	10522703
Ratio (binding)	> 60	Ratio of binding affinity against human alpha 2b-adrenoceptor by human alpha 1a-adrenoceptor	ChEMBL.	10522703
Ratio (binding)	> 60	Ratio of binding affinity against human alpha 2c-adrenoceptor by human alpha 1a-adrenoceptor	ChEMBL.	10522703

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL95578

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 159935