Detailed information for compound 1603077

Basic information

Technical information
  • TDR Targets ID: 1603077
  • Name: 3-(naphthalen-1-ylmethylideneamino)-1-(4-nitr ophenyl)urea
  • MW: 334.329 | Formula: C18H14N4O3
  • H donors: 2 H acceptors: 3 LogP: 3.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)[N+](=O)[O-])N/N=C\c1cccc2c1cccc2
  • InChi: 1S/C18H14N4O3/c23-18(20-15-8-10-16(11-9-15)22(24)25)21-19-12-14-6-3-5-13-4-1-2-7-17(13)14/h1-12H,(H2,20,21,23)/b19-12-
  • InChiKey: CCMCAPDCEKQGPS-UNOMPAQXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1-naphthylmethyleneamino)-1-(4-nitrophenyl)urea
  • NSC691664

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0107 0.0585
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0013 0.0094
Trypanosoma cruzi heat shock protein 85, putative 0.046 0.1341 0.4728
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0225
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0094 0.0233 0.1739
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0044 0.01
Loa Loa (eye worm) hypothetical protein 0.0118 0.0307 0.2289
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0094 0.0233 0.1687
Giardia lamblia Phosphatidylinositol 4-kinase 0.0036 0.0059 0.0374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Toxoplasma gondii heat shock protein 75, putative 0.0188 0.052 0.3834
Chlamydia trachomatis DNA gyrase subunit B 0.0094 0.0233 1
Echinococcus multilocularis muscleblind protein 0.032 0.092 0.092
Echinococcus granulosus Niemann Pick C1 protein 0.0289 0.0823 0.1015
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Loa Loa (eye worm) heat shock protein 90 0.046 0.1341 1
Plasmodium vivax heat shock protein 90, putative 0.0188 0.052 0.3834
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0013 0.0028
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Trichomonas vaginalis heat shock protein, putative 0.0366 0.1058 0.779
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0441
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.003 0.0153
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0013 0.0015
Trypanosoma cruzi Heat shock protein 83, putative 0.046 0.1341 0.4728
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0221
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0106 0.027 0.0333
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0036 0.0059 0.0073
Trypanosoma cruzi heat shock protein 85, putative 0.046 0.1341 0.4728
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0013 0.0094
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0107 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0013 0.0015
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Schistosoma mansoni pyruvate kinase 0.0038 0.0066 0.0149
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0188 0.0518 0.0639
Mycobacterium leprae Probable two-component sensor kinase 0.0094 0.0233 0.1742
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0068 0.0104
Echinococcus multilocularis microtubule associated protein 2 0.1481 0.4431 0.4431
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0107 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0094 0.0699
Schistosoma mansoni heat shock protein 0.046 0.1341 0.3027
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0106
Echinococcus multilocularis pyruvate kinase 0.002 0.0009 0.0009
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0094 0.0233 0.1687
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.0233 0.1681
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0013 0.0013
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.1761
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trichomonas vaginalis heat shock protein, putative 0.046 0.1341 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0059 0.0374
Brugia malayi Probable DNA topoisomerase II 0.0094 0.0233 0.1739
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0036 0.0059 0.0134
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0036 0.0059 0.0106
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0094 0.0233 0.0233
Echinococcus granulosus muscleblind protein 0.032 0.092 0.1134
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0307 0.1933
Toxoplasma gondii heat shock protein HSP90 0.046 0.1341 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0044 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Giardia lamblia Grp94/Hsp90 0.0366 0.1058 0.7872
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0801
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0188 0.0518 0.117
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0188 0.0518 0.0639
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0188 0.0518 0.3864
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0005
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0094 0.0233 0.0233
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0066 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0013 0.0094
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0188 0.0518 0.0518
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0066 0.0066
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0212 0.0262
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0013 0.0013
Brugia malayi hypothetical protein 0.0017 0.0001 0.001
Echinococcus multilocularis geminin 0.0177 0.0487 0.0487
Brugia malayi Endoplasmin precursor 0.046 0.1341 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0212 0.0212
Echinococcus multilocularis Niemann Pick C1 protein 0.0289 0.0823 0.0823
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0013 0.0028
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0082 0.0198 0.0244
Loa Loa (eye worm) MBCTL1 0.0054 0.0114 0.0847
Loa Loa (eye worm) phosphatidylinositol 3 0.0188 0.0518 0.3864
Mycobacterium ulcerans heat shock protein 90 0.0366 0.1058 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0188 0.0518 0.1695
Echinococcus multilocularis protein dispatched 1 0.0099 0.0249 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Plasmodium vivax DNA topoisomerase II, putative 0.0094 0.0233 0.1681
Brugia malayi nuclear hormone receptor 0.0021 0.0013 0.0094
Echinococcus multilocularis pyruvate kinase 0.002 0.0009 0.0009
Giardia lamblia Hypothetical protein 0.0036 0.0059 0.0374
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0044 0.0044
Echinococcus multilocularis pyruvate kinase 0.0038 0.0066 0.0066
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0106
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0441
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.1761
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.003 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0013 0.0015
Leishmania major hypothetical protein, unknown function 0.0036 0.0059 0.0102
Trypanosoma cruzi DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0233 0.1681
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Echinococcus granulosus plexin a4 0.0047 0.0092 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0066 0.013
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Brugia malayi hypothetical protein 0.0248 0.0699 0.5213
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0107 0.0419
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0123 0.0918
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0013 0.0179
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0013 0.0179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0075 0.0557
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0075 0.0169
Loa Loa (eye worm) hypothetical protein 0.0094 0.0233 0.1739
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0013 0.0015
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0036 0.0059 0.0059
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0366 0.1058 1
Echinococcus multilocularis protein patched 0.0087 0.0212 0.0212
Toxoplasma gondii DNA topoisomerase 2, putative 0.0094 0.0233 0.1681
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Schistosoma mansoni fkbp-rapamycin associated protein 0.0106 0.027 0.061
Trypanosoma cruzi DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Entamoeba histolytica protein kinase rad3, putative 0.0106 0.027 0.1829
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0106
Trichomonas vaginalis heat shock protein, putative 0.0188 0.052 0.3594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Brugia malayi mbt repeat family protein 0.0048 0.0094 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0013 0.0094
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma cruzi heat shock protein 90, putative 0.046 0.1341 0.4728
Entamoeba histolytica heat shock protein 90, putative 0.046 0.1341 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0094 0.0233 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0036 0.0059 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Giardia lamblia Heat shock protein HSP 90-alpha 0.046 0.1341 1
Echinococcus granulosus serine protein kinase ATM 0.0106 0.027 0.0333
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0066 0.0491
Schistosoma mansoni plexin 0.0023 0.002 0.0045
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0066 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0013 0.0094
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0212 0.1581
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0366 0.1058 0.3566
Mycobacterium ulcerans putative regultory protein 0.0094 0.0233 0.1687
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0102
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0036 0.0059 0.0073
Trichomonas vaginalis endoplasmin, putative 0.0282 0.0803 0.5804
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0188 0.0518 0.3725
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trichomonas vaginalis heat shock protein, putative 0.0366 0.1058 0.779
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0699 0.0862
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0188 0.0518 0.3721
Loa Loa (eye worm) plexin A 0.0047 0.0092 0.0685
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0094 0.0233 0.3329
Echinococcus multilocularis pyruvate kinase 0.002 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0036 0.0059 0.0217
Toxoplasma gondii heat shock protein 90, putative 0.046 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.027 0.2016
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.0561 0.4182
Plasmodium vivax endoplasmin, putative 0.046 0.1341 1
Brugia malayi heat shock protein 90 0.046 0.1341 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Echinococcus granulosus GPCR family 2 0.0018 0.0005 0.0006
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0188 0.0518 0.3725
Echinococcus granulosus expressed conserved protein 0.019 0.0524 0.0646
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0066 0.094
Brugia malayi kinase, mitochondrial precursor 0.0094 0.0233 0.1739
Trichomonas vaginalis receptor histidine kinase, putative 0.0094 0.0233 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0073
Echinococcus multilocularis GPCR, family 2 0.0018 0.0005 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0248 0.0699 0.5213
Brugia malayi plexin A 0.0047 0.0092 0.0685
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0013 0.0094
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0036 0.0059 0.0134
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0094 0.0233 0.0288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0013 0.0028
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0106
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0517 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0198 0.108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0013 0.0094
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0044 0.01
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0366 0.1058 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.003 0.0153
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0107 0.0483
Mycobacterium leprae Probable two component sensor kinase MprB 0.0094 0.0233 0.1742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0013 0.0094
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0107 0.0483
Schistosoma mansoni hypothetical protein 0.0039 0.0068 0.0154
Schistosoma mansoni coup transcription factor 0.0021 0.0013 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0075 0.0169
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Loa Loa (eye worm) hypothetical protein 0.0038 0.0066 0.0491
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0013 0.0015
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0701 0.5002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0094 0.0233 0.1742
Trypanosoma cruzi heat shock protein 90, putative 0.0366 0.1058 0.3706
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0094 0.0233 0.1742
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0094 0.0116
Onchocerca volvulus 0.0036 0.0059 0.0845
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.003 0.0153
Schistosoma mansoni plexin 0.004 0.007 0.0158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0161 0.0795
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0013 0.0028
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0114 0.0114
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0107 0.0585
Plasmodium falciparum endoplasmin, putative 0.0282 0.0803 0.5961
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Brugia malayi hypothetical protein 0.0041 0.0075 0.0559
Brugia malayi CHE-14 protein 0.0087 0.0212 0.1581
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0013 0.0028
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0066 0.094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0005 0.0035
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0068 0.0084
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0036 0.0059 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Leishmania major hypothetical protein, conserved 0.0979 0.2913 1
Schistosoma mansoni heat shock protein 0.046 0.1341 0.3027
Plasmodium falciparum heat shock protein 90, putative 0.0188 0.052 0.3834
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0013 0.0094
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0075 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0013 0.0094
Echinococcus granulosus geminin 0.0177 0.0487 0.06
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0188 0.052 0.3733
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0229
Brugia malayi Pre-SET motif family protein 0.0218 0.0609 0.4543
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0094 0.0233 0.1742
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0517 0.0517
Trichomonas vaginalis heat shock protein, putative 0.0366 0.1058 0.779
Leishmania major pyruvate kinase 0.0038 0.0066 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Brugia malayi Muscleblind-like protein 0.032 0.092 0.6858
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0118 0.0307 0.2115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0013 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0013 0.0013
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0094 0.0233 0.3329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0036 0.0059 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0161 0.0795
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0013 0.0094
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0036 0.0059 0.0073
Echinococcus multilocularis plexin a4 0.0047 0.0092 0.0092
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0068 0.0437
Echinococcus multilocularis 0.0036 0.0059 0.0059
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0106 0.027 0.027
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.0561 0.4046
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0094 0.0233 0.1742
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0094 0.0233 0.1742
Plasmodium vivax hypothetical protein 0.0036 0.0059 0.0374
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0094 0.0233 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni hypothetical protein 0.0082 0.0198 0.0446
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0066 0.0491
Loa Loa (eye worm) hypothetical protein 0.007 0.0161 0.1201
Loa Loa (eye worm) hypothetical protein 0.004 0.007 0.0521
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0094 0.0233 0.1687
Plasmodium falciparum DNA gyrase subunit B 0.0094 0.0233 0.1681
Schistosoma mansoni hypothetical protein 0.0041 0.0075 0.0169
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0031 0.0229
Trypanosoma brucei DNA topoisomerase ii 0.0094 0.0233 0.1552
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.2696 0.8111 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0094 0.0233 0.1742
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0013 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0013 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0374
Treponema pallidum heat shock protein 90 0.0366 0.1058 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0188 0.052 0.3834
Plasmodium vivax SET domain protein, putative 0.0031 0.0044 0.0263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0013 0.0013
Loa Loa (eye worm) TOPoisomerase family member 0.0094 0.0233 0.1739
Echinococcus granulosus heat shock protein 90 0.046 0.1341 0.1654
Giardia lamblia GTOR 0.0188 0.0518 0.3821
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0036 0.0059 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0107 0.0269
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0066 0.0491
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Schistosoma mansoni patched 1 0.0087 0.0212 0.0479
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma cruzi heat shock protein, putative 0.0188 0.052 0.1767
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Loa Loa (eye worm) hypothetical protein 0.0087 0.0212 0.1581
Trichomonas vaginalis heat shock protein, putative 0.0282 0.0803 0.5804
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0331
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Trypanosoma cruzi target of rapamycin kinase 3 0.0188 0.0518 0.1761
Onchocerca volvulus 0.005 0.0103 0.1466
Loa Loa (eye worm) hypothetical protein 0.0094 0.0233 0.1739
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0509
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0041 0.005
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0114 0.014
Schistosoma mansoni hypothetical protein 0.0289 0.0825 0.1861
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0066 0.094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0075 0.0075
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.027 0.2016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0801
Brugia malayi Hsp90 protein 0.0188 0.052 0.3877
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0188 0.0518 0.1761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0188 0.0518 0.1695
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0107 0.0585
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0094 0.0233 0.1742
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0013 0.0028
Echinococcus granulosus heat shock protein 0.046 0.1341 0.1654
Onchocerca volvulus 0.0031 0.0044 0.0634
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0036 0.0059 0.0134
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0094 0.0233 0.1687
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0123 0.0918
Loa Loa (eye worm) hypothetical protein 0.0106 0.0271 0.2021
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0066 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Leishmania major mitochondrial DNA topoisomerase II 0.0094 0.0233 0.0706
Brugia malayi ecdysteroid receptor 0.0021 0.0013 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0044 0.01
Loa Loa (eye worm) phosphatidylinositol 3 0.0188 0.0518 0.3864
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0188 0.0518 0.0518
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0013 0.0013
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0094 0.0233 0.1687
Schistosoma mansoni DNA topoisomerase II 0.0094 0.0233 0.0526
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0075 0.0092
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0094 0.0233 0.1739
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0036 0.0059 0.0073
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0188 0.0518 0.3721
Echinococcus granulosus pyruvate kinase 0.002 0.0009 0.0012
Schistosoma mansoni pyruvate kinase 0.002 0.0009 0.0021
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0013 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0801
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0036 0.0059 0.0374
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi steroid hormone receptor 0.0021 0.0013 0.0094
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0188 0.052 0.0641
Echinococcus granulosus pyruvate kinase 0.002 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.005 0.0103 0.0232
Mycobacterium tuberculosis Possible two component sensor kinase 0.0094 0.0233 0.1742
Echinococcus multilocularis pyruvate kinase 0.0038 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0094 0.0233 0.1739
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0036 0.0059 0.0374
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0106 0.027 0.061
Leishmania major hypothetical protein, conserved 0.0094 0.0233 0.0706
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2696 0.8111 0.8111
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0013 0.0094
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0094 0.0233 0.1552
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0068 0.0018
Loa Loa (eye worm) phosphatidylinositol kinase 0.0036 0.0059 0.0441
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0188 0.0518 0.3864
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0066 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0943 0.2804 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0094 0.0233 0.1357
Schistosoma mansoni heat shock protein 0.0188 0.052 0.1173
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0036 0.0059 0.0225
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.027 0.2016
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0094 0.0233 0.1742
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0013 0.0015
Schistosoma mansoni pyruvate kinase 0.0038 0.0066 0.0149
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0013 0.0028
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0106
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.007 0.0161 0.0474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0075 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Plasmodium vivax heat shock protein 86, putative 0.046 0.1341 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0217
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0094 0.0233 0.1552
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.3725
Leishmania major phosphatidylinositol kinase related protein, putative 0.0036 0.0059 0.0102
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.1695
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0066 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.1481 0.4431 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0188 0.0518 0.3821
Trypanosoma cruzi heat shock protein 85, putative 0.046 0.1341 0.4728
Onchocerca volvulus 0.0036 0.0059 0.0845
Brugia malayi Plexin repeat family protein 0.004 0.007 0.0521
Leishmania major developmentally regulated phosphoprotein-like protein 0.0094 0.0233 0.0706
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0188 0.052 0.052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0013 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0107 0.0483
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0013 0.0028
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0106 0.027 0.1836
Leishmania major DNA topoisomerase ii 0.0094 0.0233 0.0706
Schistosoma mansoni hypothetical protein 0.0177 0.0487 0.1099
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Brugia malayi hypothetical protein 0.0026 0.003 0.0221
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Loa Loa (eye worm) hypothetical protein 0.032 0.092 0.6858
Schistosoma mansoni endoplasmin 0.046 0.1341 0.3027
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi nuclear receptor NHR-88 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0202 0.0561 0.4182
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0066 0.0424
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0094 0.0212
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0036 0.0059 0.0134
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.0233 0.1681
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0013 0.0013
Plasmodium falciparum DNA topoisomerase 2 0.0094 0.0233 0.1681
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0094 0.0233 0.0288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0123 0.0918
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0066 0.0491
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0013 0.0013
Plasmodium vivax DNA gyrase subunit B, putative 0.0094 0.0233 0.1681
Leishmania major heat shock protein, putative 0.0188 0.052 0.17
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0013 0.0094
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0059 0.0374
Echinococcus multilocularis pyruvate kinase 0.003 0.0041 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0107 0.0483
Schistosoma mansoni pyruvate dehydrogenase 0.0094 0.0233 0.0526
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Echinococcus granulosus endoplasmin 0.0366 0.1058 0.1304
Onchocerca volvulus 0.004 0.007 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0013 0.0094
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0107 0.0801
Echinococcus multilocularis expressed conserved protein 0.019 0.0524 0.0524
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0066 0.0424
Trypanosoma brucei heat shock protein 84, putative 0.0188 0.052 0.3738
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0013 0.0094
Giardia lamblia Pms1-like protein 0.0094 0.0233 0.1681
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0114 0.014
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0094 0.0233 0.1742
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0118 0.0307 0.2235
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0059 0.0374
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0036 0.0059 0.0059
Leishmania major phosphatidylinositol kinase, putative 0.0036 0.0059 0.0102
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0225
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trypanosoma cruzi heat shock protein 90, putative 0.0271 0.0771 0.2673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0013 0.0094
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0094 0.0094
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0107 0.0419
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0094 0.0116
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0106 0.027 0.0868
Echinococcus granulosus pyruvate kinase 0.0038 0.0066 0.0081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0374
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0114 0.0256
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0036 0.0059 0.0225
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0044 0.0055
Entamoeba histolytica DNA topoisomerase II, putative 0.0094 0.0233 0.1545
Mycobacterium ulcerans hypothetical protein 0.0052 0.0107 0.0419
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0107 0.0801
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0013 0.0028
Leishmania major pyruvate kinase 0.0038 0.0066 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.0307 0.1933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma brucei Heat shock protein 83, putative 0.046 0.1341 1
Onchocerca volvulus 0.0048 0.0094 0.1338
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0699 0.0699
Loa Loa (eye worm) hypothetical protein 0.0054 0.0114 0.0847
Schistosoma mansoni survival motor neuron protein 0.005 0.0103 0.0232
Plasmodium vivax heat shock protein, putative 0.0188 0.052 0.3834
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Leishmania major phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0102
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0036 0.0059 0.0374
Leishmania major phosphatidylinositol 3-kinase, putative 0.0188 0.0518 0.1695
Schistosoma mansoni endoplasmin 0.046 0.1341 0.3027
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0094 0.0233 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0094 0.0233 0.1357
Echinococcus multilocularis muscleblind protein 1 0.032 0.092 0.092
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.0561 0.0692
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0114 0.0847
Entamoeba histolytica hypothetical protein 0.0106 0.027 0.1829
Chlamydia trachomatis DNA gyrase subunit B 0.0094 0.0233 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0094 0.0233 0.1687
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Mycobacterium ulcerans two component regulator - sensor kinase 0.0094 0.0233 0.1687
Mycobacterium tuberculosis Probable two component sensor kinase 0.0094 0.0233 0.1742
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0188 0.0518 0.3725
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0094 0.0094
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0094 0.0233 0.3329
Echinococcus granulosus microtubule associated protein 2 0.1481 0.4431 0.5464
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0103 0.0765
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0147
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.0045
Echinococcus granulosus heat shock protein 90 0.0366 0.1058 0.1304
Trypanosoma brucei heat shock protein 90, putative 0.046 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.032 0.092 0.6858
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0075 0.0092
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0094 0.0233 0.1357
Plasmodium falciparum heat shock protein 90 0.046 0.1341 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0102
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0094 0.0233 0.1681
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0094 0.0233 0.1357
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0094 0.0233 0.1742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus multilocularis serine protein kinase ATM 0.0106 0.027 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0036 0.0059 0.0441
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0699
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0013 0.0028
Echinococcus multilocularis heat shock protein 90 0.0366 0.1058 0.1058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0107 0.0419
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0094 0.0233 0.1687
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0005 0.0035
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0082 0.0198 0.0198
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0094 0.0212
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0094 0.0233 0.1552
Echinococcus multilocularis endoplasmin 0.0366 0.1058 0.1058
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0094 0.0233 0.1742
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0094 0.0233 0.0734
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0374
Giardia lamblia Heat shock protein HSP 90-alpha 0.0366 0.1058 0.7872
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.0561 0.0561
Onchocerca volvulus 0.0021 0.0013 0.0179
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0188 0.0518 0.3725
Mycobacterium ulcerans DNA gyrase subunit B 0.0094 0.0233 0.1687
Trichomonas vaginalis DNA topoisomerase II, putative 0.0094 0.0233 0.1357
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0036 0.0059 0.0106
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0094 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0366 0.1058 1
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Trypanosoma brucei heat shock protein 90, putative 0.046 0.1341 1
Entamoeba histolytica heat shock protein 90, putative 0.046 0.1341 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.057 0.1287
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0036 0.0059 0.0217
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0188 0.0518 0.1695
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0188 0.052 0.7423
Onchocerca volvulus 0.0019 0.0008 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0075 0.0557
Plasmodium falciparum heat shock protein 90, putative 0.0188 0.052 0.3834
Echinococcus multilocularis Zinc finger, PHD finger 0.0036 0.0059 0.0059
Echinococcus multilocularis heat shock protein 90 0.046 0.1341 0.1341
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0036 0.0059 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0107 0.0419
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0094 0.0233 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0013 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0094 0.0233 0.1742
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0188 0.0518 0.1761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0075 0.0075
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0036 0.0059 0.0374
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0114 0.0114
Onchocerca volvulus 0.0052 0.0107 0.1533
Trypanosoma brucei developmentally regulated phosphoprotein 0.0094 0.0233 0.1552
Echinococcus granulosus pyruvate kinase 0.002 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.0036 0.0059 0.0134
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0106 0.027 0.1829
Brugia malayi FAT domain containing protein 0.0082 0.0198 0.1474
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0013 0.0094
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0036 0.0059 0.0106
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0066 0.0052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0044 0.0263
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0094 0.0233 0.1742
Trichomonas vaginalis receptor histidine kinase, putative 0.0094 0.0233 0.1357
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0106 0.027 0.0868
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0107 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0057 0.0123 0.0918
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0094 0.1338
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0013 0.0028
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0036 0.0059 0.0441
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0068 0.0437
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0609 0.4543
Trypanosoma cruzi heat shock protein 85, putative 0.0366 0.1058 0.3706
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0013 0.0179
Echinococcus multilocularis heat shock protein 0.046 0.1341 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Loa Loa (eye worm) heat shock protein 75 0.0188 0.052 0.3877
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0066 0.0491
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0005 0.0035
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Mycobacterium tuberculosis Conserved protein 0.0094 0.0233 0.1742
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0212 0.0262
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.0233 0.1681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0075 0.0169
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0107 0.0419
Onchocerca volvulus 0.0248 0.0701 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0366 0.1058 0.1304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0036 0.0059 0.0106
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0059
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0188 0.0518 0.117
Loa Loa (eye worm) endoplasmin 0.046 0.1341 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0005
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0198 0.1474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0044 0.01
Schistosoma mansoni hypothetical protein 0.0177 0.0487 0.1099
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0044 0.0044
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0094 0.0233 0.0233
Mycobacterium ulcerans two component sensor kinase MprB 0.0094 0.0233 0.1687
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0068 0.0509
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0013 0.0015
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0094 0.0233 0.0734
Echinococcus granulosus pyruvate kinase 0.0038 0.0066 0.0081
Giardia lamblia Pyruvate kinase 0.0038 0.0066 0.0424
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0036 0.0059 0.0059
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0107 0.0801
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0107 0.0419
Toxoplasma gondii FATC domain-containing protein 0.0106 0.027 0.196
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0212 0.1192
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Plasmodium falciparum pyruvate kinase 0.0038 0.0066 0.0424
Brugia malayi mbt repeat family protein 0.0048 0.0094 0.0699

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.176 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.094 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.051 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.936 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.893 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.849 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.814 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.733 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.719 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.646 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.392 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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