TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.358 | Formula: C16H18NO2PS
H donors: 0 H acceptors: 1 LogP: 4.51 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC1(C)CO[P@](=S)(O[C@@H]1c1ccccc1)c1ccccn1
InChi: 1S/C16H18NO2PS/c1-16(2)12-18-20(21,14-10-6-7-11-17-14)19-15(16)13-8-4-3-5-9-13/h3-11,15H,12H2,1-2H3/t15-,20+/m1/s1
InChiKey: PFWNRRXWRSEWGF-QRWLVFNGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	sugar transporter	0.0849	0.1243	1
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0849	0.1243	1
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Schistosoma mansoni	glucose transport protein	0.0849	0.1243	0.1237
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0057	0.0031	0.0251
Schistosoma mansoni	sugar transporter	0.0849	0.1243	0.1237
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0122	0.0131	0.1005
Echinococcus granulosus	hypothetical protein	0.012	0.0127	0.0127
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0057	0.0031	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Echinococcus granulosus	protein kinase c iota type	0.0232	0.0298	0.0298
Giardia lamblia	Hexose transporter	0.0849	0.1243	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0236	0.0304	0.0315
Leishmania major	cytochrome p450-like protein	0.0085	0.0075	0.0552
Trichomonas vaginalis	sugar transport protein, putative	0.0849	0.1243	1
Echinococcus granulosus	sodium channel protein	0.0074	0.0057	0.0057
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0074	0.0057	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0068	0.0048	0.0143
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0119	0.0126	0.0965
Echinococcus granulosus	cytochrome P450 2K1	0.0057	0.0031	0.0031
Echinococcus granulosus	synaptic vesicle 2 protein	0.0849	0.1243	0.1243
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0057	0.0031	0.0251
Schistosoma mansoni	hypothetical protein	0.0057	0.0031	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0232	0.0298	0.0309
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	myotubularin protein 13	0.0229	0.0295	0.0295
Trichomonas vaginalis	CMGC family protein kinase	0.0109	0.0111	0.0849
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0232	0.0298	0.0294
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0253	0.0331	0.2629
Brugia malayi	Protein kinase domain containing protein	0.0122	0.0131	0.0135
Echinococcus granulosus	Protein kinase C brain isozyme	0.0232	0.0298	0.0298
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0068	0.0048	0.0042
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0134	0.0149	0.1158
Echinococcus granulosus	protein kinase c eta type	0.0229	0.0295	0.0295
Loa Loa (eye worm)	sugar transporter	0.0849	0.1243	0.1243
Trypanosoma cruzi	cytochrome P450, putative	0.0085	0.0075	0.0552
Brugia malayi	RhoGAP domain containing protein	0.0229	0.0295	0.0305
Toxoplasma gondii	sugar transporter ST2	0.0849	0.1243	1
Schistosoma mansoni	hypothetical protein	0.0229	0.0295	0.0289
Brugia malayi	diacylglycerol kinase	0.0229	0.0295	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	sodium channel protein	0.0074	0.0057	0.0057
Brugia malayi	Pleckstrin Homology Domain	0.0229	0.0295	0.0305
Trypanosoma brucei	protein kinase, putative	0.0109	0.0111	0.0849
Plasmodium vivax	sugar transporter, putative	0.0849	0.1243	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0109	0.0111	0.0849
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0236	0.0304	0.0304
Loa Loa (eye worm)	raf kinase	0.6545	0.9951	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0229	0.0295	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0076	0.0071
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0421	0.0587	0.4696
Trichomonas vaginalis	glucose transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	glucose transport protein	0.0849	0.1243	0.1237
Trypanosoma cruzi	hexose transporter, putative	0.0849	0.1243	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0849	0.1243	0.1243
Echinococcus granulosus	solute carrier family 22	0.0849	0.1243	0.1243
Trichomonas vaginalis	myo-inositol transporter, putative	0.0849	0.1243	1
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Schistosoma mansoni	glucose transporter	0.0849	0.1243	0.1237
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0122	0.0131	0.0124
Onchocerca volvulus		0.0849	0.1243	1
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0057	0.0031	0.0251
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	solute carrier family 22	0.0849	0.1243	0.1243
Onchocerca volvulus		0.0849	0.1243	1
Trichomonas vaginalis	CMGC family protein kinase	0.0109	0.0111	0.0849
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.008	0.0074
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0122	0.0131	0.0125
Brugia malayi	major facilitator superfamily protein	0.0849	0.1243	0.1288
Brugia malayi	Cytochrome P450 family protein	0.0222	0.0284	0.0294
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Brugia malayi	diacylglycerol kinase	0.0229	0.0295	0.0305
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0229	0.0295	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.008	0.127
Schistosoma mansoni	serine/threonine protein kinase	0.6577	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0057	0.0031	0.0251
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0255	0.0334	0.033
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0421	0.0587	0.0608
Leishmania major	cytochrome p450-like protein	0.0057	0.0031	0.0202
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	serine/threonine protein kinase	0.0232	0.0298	0.0292
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0057	0.0031	0.0202
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0109	0.0111	0.0849
Trichomonas vaginalis	CMGC family protein kinase	0.0122	0.0131	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Entamoeba histolytica	diacylglycerol kinase, putative	0.0229	0.0295	0.4967
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0109	0.0111	0.0849
Brugia malayi	protein kinase C3,putative	0.0232	0.0298	0.0309
Brugia malayi	Sugar transporter family protein	0.0849	0.1243	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Schistosoma mansoni	atypical protein kinase C	0.0232	0.0298	0.0292
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0057	0.0031	0.0251
Brugia malayi	hypothetical protein	0.0166	0.0198	0.0205
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0319	0.0432	0.3445
Schistosoma mansoni	single-minded	0.005	0.002	0.0013
Brugia malayi	hypothetical protein	0.0849	0.1243	0.1288
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0849	0.1243	1
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0068	0.0048	0.0342
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0068	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Echinococcus multilocularis	microtubule associated protein 2	0.0761	0.1107	0.1107
Leishmania major	glucose transporter, lmgt1	0.0849	0.1243	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0598	0.0859	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0227	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0232	0.0298	0.0298
Toxoplasma gondii	sugar transporter ST3	0.0849	0.1243	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0229	0.0295	0.4967
Schistosoma mansoni	microtubule-associated protein tau	0.0761	0.1107	0.1102
Schistosoma mansoni	serine/threonine protein kinase	0.0122	0.0131	0.0124
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0849	0.1243	0.1243
Onchocerca volvulus		0.0849	0.1243	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0849	0.1243	0.1243
Loa Loa (eye worm)	CYP4Cod1	0.0085	0.0075	0.0069
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0082	0.0069	0.0504
Brugia malayi	Cytochrome P450 family protein	0.0085	0.0075	0.0077
Schistosoma mansoni	cytochrome P450	0.0057	0.0031	0.0025
Loa Loa (eye worm)	phosphatidylinositol 3	0.0119	0.0126	0.012
Brugia malayi	Major Facilitator Superfamily protein	0.0849	0.1243	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Echinococcus multilocularis	dual specificity	0.0089	0.008	0.008
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0849	0.1243	1
Trypanosoma cruzi	sugar transporter, putative	0.0849	0.1243	1
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0057	0.0031	0.0202
Onchocerca volvulus		0.0229	0.0295	0.2371
Onchocerca volvulus		0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0849	0.1243	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0229	0.0295	0.0295
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0232	0.0298	0.0298
Echinococcus multilocularis	protein kinase c eta type	0.0229	0.0295	0.0295
Trichomonas vaginalis	CMGC family protein kinase	0.0109	0.0111	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Echinococcus granulosus	solute carrier family 22	0.0849	0.1243	0.1243
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0134	0.0149	0.1158
Onchocerca volvulus	Putative transporter	0.0849	0.1243	1
Giardia lamblia	Sugar-proton symporter	0.0849	0.1243	1
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0089	0.008	0.0074
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0849	0.1243	0.1243
Loa Loa (eye worm)	phosphatidylinositol 3	0.0532	0.0758	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Mycobacterium leprae	putative cytochrome p450	0.0057	0.0031	0.5
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0232	0.0298	0.0294
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0849	0.1243	0.5
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0109	0.0111	0.0849
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0232	0.0298	0.0309
Brugia malayi	RhoGAP domain containing protein	0.0229	0.0295	0.0305
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0421	0.0587	1
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0122	0.0131	0.082
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0421	0.0587	0.4696
Echinococcus granulosus	Rac GTPase activating protein 1	0.0229	0.0295	0.0295
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0849	0.1243	0.1243
Trypanosoma brucei	glucose transporter 1E	0.0849	0.1243	1
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Brugia malayi	MAP kinase sur-1	0.0109	0.0111	0.0115
Schistosoma mansoni	serine/threonine protein kinase	0.0232	0.0298	0.0292
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus granulosus	myotubularin protein 13	0.0229	0.0295	0.0295
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0006	0.0006
Echinococcus granulosus	unc 13 munc13	0.0229	0.0295	0.0295
Leishmania major	glucose transporter, lmgt3	0.0849	0.1243	1
Brugia malayi	hypoxia-induced factor 1	0.0153	0.0178	0.0185
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0122	0.0131	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0068	0.0048	0.0342
Onchocerca volvulus		0.0849	0.1243	1
Schistosoma mansoni	serine/threonine protein kinase	0.0232	0.0298	0.0292
Echinococcus multilocularis	raf serine:threonine protein kinase	0.6577	1	1
Trichomonas vaginalis	glucose transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0849	0.1243	0.1243
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0068	0.0048	0.0342
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0598	0.0859	0.0853
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0421	0.0587	0.4696
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0057	0.0031	0.0202
Echinococcus multilocularis	solute carrier family 22	0.0849	0.1243	0.1243
Entamoeba histolytica	hypothetical protein	0.0089	0.008	0.127
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0849	0.1243	0.1237
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0068	0.0048	0.0727
Echinococcus granulosus	protein kinase c epsilon type	0.0232	0.0298	0.0298
Toxoplasma gondii	diacylglycerol kinase, putative	0.0229	0.0295	0.2175
Trypanosoma cruzi	hexose transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	N chimaerin	0.0229	0.0295	0.0295
Echinococcus granulosus	solute carrier family 22	0.0849	0.1243	0.1243
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0849	0.1243	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Brugia malayi	Ras association domain family 1 isoform A	0.0229	0.0295	0.0305
Trypanosoma brucei	cytochrome P450, putative	0.0085	0.0075	0.0552
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0229	0.0295	0.029
Onchocerca volvulus		0.0849	0.1243	1
Onchocerca volvulus		0.0849	0.1243	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0085	0.0075	0.0069
Entamoeba histolytica	hypothetical protein	0.0229	0.0295	0.4967
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0232	0.0298	0.0294
Brugia malayi	follicle stimulating hormone receptor	0.0255	0.0334	0.0347
Plasmodium vivax	serine/threonine kinase-1, putative	0.0122	0.0131	0.0687
Echinococcus granulosus	ubiquitin specific protease 41	0.0041	0.0006	0.0006
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0068	0.0048	0.0042
Brugia malayi	Major Facilitator Superfamily protein	0.0849	0.1243	0.1288
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0068	0.0048	0.0143
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0068	0.0048	0.0042
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0122	0.0131	0.1005
Echinococcus granulosus	dual specificity	0.0089	0.008	0.008
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0057	0.0031	0.0251
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0849	0.1243	1
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Giardia lamblia	Kinase, CMGC CLK	0.0122	0.0131	0.1005
Entamoeba histolytica	hypothetical protein	0.0355	0.0486	0.8262
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0849	0.1243	0.1243
Leishmania major	cytochrome p450-like protein	0.0057	0.0031	0.0202
Echinococcus granulosus	mitogen activated protein kinase 3	0.0109	0.0111	0.0111
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0057	0.0031	0.0251
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0849	0.1243	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0074	0.0057	0.0409
Brugia malayi	RhoGEF domain containing protein	0.0229	0.0295	0.0305
Onchocerca volvulus		0.0849	0.1243	1
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0057	0.0031	0.0251
Brugia malayi	Major Facilitator Superfamily protein	0.0849	0.1243	0.1288
Loa Loa (eye worm)	sugar transporter	0.0849	0.1243	0.1243
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0089	0.008	0.0597
Schistosoma mansoni	hypothetical protein	0.0849	0.1243	0.1237
Echinococcus multilocularis		0.0057	0.0031	0.0031
Brugia malayi	Cytochrome P450 family protein	0.0085	0.0075	0.0077
Schistosoma mansoni	sugar transporter	0.0849	0.1243	0.1237
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0057	0.0031	0.0251
Mycobacterium leprae	Conserved hypothetical protein	0.0057	0.0031	0.5
Brugia malayi	C1-like domain containing protein	0.0232	0.0298	0.0309
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0068	0.0048	0.0342
Plasmodium falciparum	hexose transporter	0.0849	0.1243	1
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0421	0.0587	0.4696
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0057	0.0031	0.0251
Echinococcus granulosus	mitogen activated protein kinase	0.0109	0.0111	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.3729	0.5645	0.5671
Echinococcus multilocularis	solute carrier family 22	0.0849	0.1243	0.1243
Schistosoma mansoni	unc-13 (munc13)	0.0229	0.0295	0.0289
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0068	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Mycobacterium ulcerans	integral membrane transport protein	0.0849	0.1243	1
Trichomonas vaginalis	CMGC family protein kinase	0.0109	0.0111	0.0849
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0122	0.0131	0.0131
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0057	0.0031	0.0251
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0232	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Onchocerca volvulus		0.0849	0.1243	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0134	0.0149	0.2465
Schistosoma mansoni	sugar transporter	0.0849	0.1243	0.1237
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0598	0.0859	0.0859
Onchocerca volvulus		0.0849	0.1243	1
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0153	0.0178	0.0173
Echinococcus granulosus	microtubule associated protein 2	0.0761	0.1107	0.1107
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0089	0.008	0.0597
Onchocerca volvulus		0.0229	0.0295	0.2371
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0229	0.0295	0.029
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0198	0.0193
Plasmodium falciparum	protein serine/threonine kinase-1	0.0122	0.0131	0.0687
Trypanosoma cruzi	hexose transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	rac gtpase activating protein	0.0229	0.0295	0.0289
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0849	0.1243	0.1243
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0122	0.0131	0.1005
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0057	0.0031	0.0251
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0229	0.0295	0.0295
Echinococcus granulosus	dual specificity protein kinase clk2	0.0122	0.0131	0.0131
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0319	0.0432	0.3445
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	vav2	0.0229	0.0295	0.0289
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0057	0.0031	0.0251
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0421	0.0587	0.4696
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0109	0.0111	0.0849
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0229	0.0295	0.0295
Schistosoma mansoni	aryl hydrocarbon receptor	0.005	0.002	0.0013
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0057	0.0031	0.0251
Brugia malayi	Sugar transporter family protein	0.0849	0.1243	0.1288
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0068	0.0048	0.0342
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0109	0.0111	0.0849
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Schistosoma mansoni	diacylglycerol kinase theta	0.0229	0.0295	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0849	0.1243	0.1243
Echinococcus multilocularis	mitogen activated protein kinase	0.0109	0.0111	0.0111
Toxoplasma gondii	sugar transporter ST1	0.0849	0.1243	1
Trypanosoma cruzi	hexose transporter	0.0849	0.1243	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0068	0.0048	0.0342
Schistosoma mansoni	diacylglycerol kinase theta	0.0229	0.0295	0.0289
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Brugia malayi	hypothetical protein	0.0849	0.1243	0.1288
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0134	0.0149	0.0155
Brugia malayi	Protein kinase c protein 2	0.0232	0.0298	0.0309
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0849	0.1243	0.1243
Leishmania major	hypothetical protein, conserved	0.0849	0.1243	1
Entamoeba histolytica	protein kinase, putative	0.0089	0.008	0.127
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0405	0.0563	0.9591
Leishmania major	protein kinase, putative	0.0122	0.0131	0.1005
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0068	0.0048	0.0342
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0068	0.0048	0.0048
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0134	0.0149	0.0143
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	sugar transporter	0.0849	0.1243	0.1237
Loa Loa (eye worm)	cytochrome P450 family protein	0.0222	0.0284	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0178	0.0216	0.0224
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0229	0.0295	0.0295
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0849	0.1243	0.1243
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0849	0.1243	1
Brugia malayi	hypothetical protein	0.0849	0.1243	0.1288
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0057	0.0031	0.0202
Echinococcus multilocularis	solute carrier family 22	0.0849	0.1243	0.1243
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0122	0.0131	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0134	0.0149	0.1158
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0849	0.1243	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0295	0.029
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0122	0.0131	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Onchocerca volvulus		0.0849	0.1243	1
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Echinococcus granulosus	N chimaerin	0.0229	0.0295	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0076	0.0071
Schistosoma mansoni	glucose transport protein	0.0849	0.1243	0.1237
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0068	0.0048	0.0727
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0031	0.0032
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0355	0.0486	0.8262
Brugia malayi	protein kinase C II.	0.0232	0.0298	0.0309
Loa Loa (eye worm)	hypothetical protein	0.012	0.0127	0.0121
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0089	0.008	0.0597
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0229	0.0295	0.0295
Schistosoma mansoni	protein kinase C mu	0.0232	0.0298	0.0292
Schistosoma mansoni	protein kinase C	0.0229	0.0295	0.0289
Onchocerca volvulus		0.0849	0.1243	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0849	0.1243	1
Loa Loa (eye worm)	cytochrome P450	0.0057	0.0031	0.0025
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	serine/threonine protein kinase	0.0232	0.0298	0.0292
Leishmania major	myo-inositol/proton symporter (MIT)	0.0849	0.1243	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0085	0.0075	0.06
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0057	0.0031	0.0251
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0232	0.0298	0.0298
Echinococcus multilocularis	unc 13 (munc13)	0.0229	0.0295	0.0295
Onchocerca volvulus		0.0849	0.1243	1
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0229	0.0295	0.029
Schistosoma mansoni	protein kinase C mu	0.0229	0.0295	0.0289
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Echinococcus granulosus	Diacylglycerol kinase theta	0.0229	0.0295	0.0295
Trypanosoma brucei	glucose transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	unc-13 (munc13)	0.0229	0.0295	0.0289
Echinococcus multilocularis	ubiquitin specific protease 41	0.0041	0.0006	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Onchocerca volvulus		0.0849	0.1243	1
Onchocerca volvulus		0.0849	0.1243	1
Brugia malayi	PAS domain containing protein	0.005	0.002	0.002
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0068	0.0048	0.0342
Loa Loa (eye worm)	cytochrome P450 family protein	0.0085	0.0075	0.0069
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0229	0.0295	0.029
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0089	0.008	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.017	0.0203	0.3392
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0006	0.0006
Trichomonas vaginalis	glucose transporter, putative	0.0849	0.1243	1
Echinococcus granulosus	solute carrier family 22	0.0849	0.1243	0.1243
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0229	0.0295	0.0289
Trichomonas vaginalis	sugar transporter, putative	0.0849	0.1243	1
Loa Loa (eye worm)	hypothetical protein	0.0236	0.0304	0.0299
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0236	0.0304	0.0304
Trypanosoma cruzi	glucose transporter, putative	0.0849	0.1243	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0849	0.1243	1
Trypanosoma brucei	glucose transporter 2A	0.0849	0.1243	1
Leishmania major	glucose transporter, lmgt2	0.0849	0.1243	1
Brugia malayi	Sugar transporter family protein	0.0849	0.1243	0.1288
Onchocerca volvulus		0.0229	0.0295	0.2371
Entamoeba histolytica	protein kinase, putative	0.0089	0.008	0.127
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0109	0.0111	0.0849
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0109	0.0111	0.0106
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0068	0.0048	0.0048
Leishmania major	protein kinase, putative	0.0122	0.0131	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1243	0.1243
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.0111	0.0105
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0057	0.0031	0.0251
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0134	0.0149	0.1158
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0134	0.0149	0.1158
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0068	0.0048	0.005
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0057	0.0031	0.0251
Brugia malayi	major facilitator superfamily protein	0.0849	0.1243	0.1288
Trypanosoma brucei	sugar transporter, putative	0.0849	0.1243	1
Giardia lamblia	Kinase, CMGC MAPK	0.0109	0.0111	0.0849
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0109	0.0111	0.0661
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Echinococcus granulosus	Solute carrier family 22 5	0.2256	0.3393	0.3393
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0109	0.0111	0.0111
Schistosoma mansoni	serine/threonine protein kinase	0.0232	0.0298	0.0292
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0134	0.0149	0.2465
Trypanosoma cruzi	cytochrome P450, putative	0.0085	0.0075	0.0552
Brugia malayi	Raf kinase	0.6348	0.9649	1
Echinococcus multilocularis	protein kinase c iota type	0.0232	0.0298	0.0298
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0041	0.0006	0.0006
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0057	0.0031	0.0251
Plasmodium vivax	hexose transporter	0.0849	0.1243	1
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0057	0.0031	0.0251
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0057	0.0031	0.0202
Trichomonas vaginalis	conserved hypothetical protein	0.0849	0.1243	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0006	0.0006
Trypanosoma cruzi	hexose transporter, putative	0.0849	0.1243	1
Echinococcus multilocularis		0.012	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0089	0.008	0.0083
Brugia malayi	Variant SH3 domain containing protein	0.0229	0.0295	0.0305
Onchocerca volvulus		0.0849	0.1243	1
Brugia malayi	cytochrome P450	0.0057	0.0031	0.0032

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.083	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.049	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.022	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1989600

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1603684