TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 547.465 | Formula: C25H24F7N3O3
H donors: 1 H acceptors: 3 LogP: 4.11 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: Fc1ccc(c(c1)C)[C@H]1CN(CC[C@@H]1C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C(=O)C(=O)N
InChi: 1S/C25H24F7N3O3/c1-13-7-17(26)3-4-18(13)20-12-35(23(38)21(33)36)6-5-19(20)22(37)34(2)11-14-8-15(24(27,28)29)10-16(9-14)25(30,31)32/h3-4,7-10,19-20H,5-6,11-12H2,1-2H3,(H2,33,36)/t19-,20+/m0/s1
InChiKey: JNSYLTHKBVSSSE-VQTJNVASSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0108	0.0212
Onchocerca volvulus		0.086	0.4642	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0016	0.0045	0.0075
Plasmodium vivax	RING zinc finger protein, putative	0.0016	0.004	0.0064
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0306	0.1622	0.3481
Brugia malayi	hypothetical protein	0.0016	0.004	0.0064
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0016	0.004	0.0064
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0016	0.0045	0.0035
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0011	0.0015	0.001
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0011	0.0015	0.001
Echinococcus multilocularis	expressed conserved protein	0.0012	0.0018	0.0008
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0011	0.0015	0.003
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Echinococcus multilocularis	SWI:SNF matrix associated	0.086	0.4642	0.4637
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0016	0.004	0.003
Treponema pallidum	catabolite gene activator	0.0011	0.0015	0.5
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0016	0.004	0.0064
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0011	0.0015	0.0005
Trypanosoma brucei	ring finger containing protein	0.0016	0.004	0.0245
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0016	0.004	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Leishmania major	hypothetical protein, unknown function	0.0016	0.004	0.0185
Brugia malayi	brahma associated protein 60 kDa	0.086	0.4642	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Schistosoma mansoni	RNA binding protein	0.0306	0.1622	0.3481
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.045	0.095
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0016	0.004	0.003
Echinococcus multilocularis	ring and YY1 binding protein	0.0306	0.1622	0.1614
Mycobacterium tuberculosis	Conserved protein	0.0011	0.0015	0.5
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Leishmania major	hypothetical protein, conserved	0.0011	0.0015	0.003
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0011	0.0015	0.0005
Trypanosoma brucei	DNA repair protein, putative	0.0016	0.004	0.0245
Giardia lamblia	Kinase, NEK	0.0016	0.0043	1
Entamoeba histolytica	SPRY domain protein	0.0016	0.004	1
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1622	0.3481
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1622	0.3481
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Echinococcus granulosus	hyperpolarization activated cyclic	0.0016	0.0045	0.0035
Trypanosoma cruzi	cAMP binding protein, putative	0.0011	0.0015	0.003
Leishmania major	hypothetical protein	0.0016	0.004	0.0185
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0306	0.1622	0.3481
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0083	0.0408	0.086
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Schistosoma mansoni	hypothetical protein	0.0306	0.1622	0.3481
Schistosoma mansoni	hypothetical protein	0.0011	0.0015	0.001
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0108	0.0212
Trypanosoma brucei	cAMP binding protein, putative	0.0011	0.0015	0.0091
Trichomonas vaginalis	ion channel nompc, putative	0.0016	0.004	0.0064
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Schistosoma mansoni	ring finger protein 151	0.0016	0.004	0.0064
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0237	0.1245	0.2666
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.004	0.0185
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0016	0.0045	0.0075
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0083	0.0408	0.0399
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0011	0.0015	0.001
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1622	0.3481
Giardia lamblia	Hypothetical protein	0.0016	0.004	0.8799
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0306	0.1622	0.3474
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Toxoplasma gondii	helicase, putative	0.0016	0.004	0.0054
Plasmodium falciparum	zinc finger protein, putative	0.0016	0.004	0.0064
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0306	0.1622	1
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Trypanosoma brucei	hypothetical protein, conserved	0.0306	0.1622	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0086	0.0165
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0016	0.004	0.0064
Plasmodium vivax	DNA repair protein RAD5, putative	0.0016	0.004	0.0064
Echinococcus multilocularis	voltage gated potassium channel	0.0024	0.0086	0.0076
Leishmania major	hypothetical protein, conserved	0.0011	0.0015	0.003
Plasmodium falciparum	RING zinc finger protein, putative	0.0016	0.004	0.0064
Trypanosoma brucei	cytochrome P450, putative	0.0028	0.0108	0.0666
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0012	0.0018	0.0007
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0016	0.004	0.0054
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.0379	0.0796
Brugia malayi	hypothetical protein	0.0016	0.004	0.0064
Plasmodium vivax	zinc finger protein, putative	0.0016	0.004	0.0064
Schistosoma mansoni	cellular tumor antigen P53	0.027	0.1425	0.3055
Echinococcus multilocularis	ring finger protein 113a	0.0016	0.004	0.003
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0016	0.004	0.003
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0016	0.004	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0015	0.003
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Brugia malayi	RING finger protein 20	0.0016	0.004	0.0064
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0011	0.0015	0.001
Giardia lamblia	Hypothetical protein	0.0016	0.004	0.8799
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.086	0.4642	0.4637
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0016	0.0045	0.0035
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0011	0.0015	0.0005
Brugia malayi	brahma associated protein 60 kDa	0.086	0.4642	1
Onchocerca volvulus		0.0016	0.004	0.0064
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0306	0.1622	0.3481
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0011	0.0015	0.0005
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0306	0.1622	1
Giardia lamblia	Kinase	0.0016	0.0043	1
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0016	0.004	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Brugia malayi	hypothetical protein	0.0016	0.004	0.0064
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0016	0.004	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.004	0.0185
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0016	0.0045	0.0035
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0011	0.0015	0.0091
Schistosoma mansoni	rnf5	0.0016	0.004	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Leishmania major	hypothetical protein, conserved	0.0011	0.0015	0.003
Schistosoma mansoni	hypothetical protein	0.086	0.4642	1
Schistosoma mansoni	voltage-gated potassium channel	0.0016	0.0045	0.0075
Mycobacterium leprae	Conserved hypothetical protein	0.0011	0.0015	0.5
Treponema pallidum	catabolite gene activator (Crp)	0.0011	0.0015	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0024	0.0086	0.0076
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0011	0.0015	0.001
Trichomonas vaginalis	ankyrin, putative	0.0016	0.004	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.045	0.095
Trypanosoma cruzi	cAMP response protein 1	0.0011	0.0015	0.003
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Plasmodium vivax	trophozoite exported protein 1, putative	0.0016	0.004	0.0064
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0016	0.0045	0.0075
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Giardia lamblia	Ribonuclease	0.0016	0.004	0.8799
Onchocerca volvulus		0.0016	0.004	0.0064
Loa Loa (eye worm)	brahma associated protein	0.086	0.4642	1
Leishmania major	DNA repair protein-like protein	0.0016	0.004	0.0185
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0083	0.0408	0.0399
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0083	0.0408	0.086
Toxoplasma gondii	hypothetical protein	0.0016	0.004	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.004	0.0185
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Toxoplasma gondii	hypothetical protein	0.0016	0.004	0.0054
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Brugia malayi	Zinc finger protein 183 homolog	0.0016	0.004	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1622	0.3481
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0016	0.004	0.003
Echinococcus multilocularis	ring finger protein 170	0.0016	0.004	0.003
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0016	0.0045	0.0075
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0016	0.004	0.8799
Brugia malayi	N-terminal motif family protein	0.0011	0.0015	0.001
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Echinococcus granulosus	RING finger protein 185	0.0016	0.004	0.003
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Onchocerca volvulus		0.0016	0.004	0.0064
Trypanosoma cruzi	cAMP response protein 1, putative	0.0011	0.0015	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0011	0.0015	0.0005
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0306	0.1622	0.3481
Brugia malayi	Protein kinase domain containing protein	0.0237	0.1245	0.2666
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0016	0.004	0.0064
Trypanosoma brucei	predicted zinc finger protein	0.0016	0.004	0.0245
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0012	0.0018	0.0008
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0011	0.0015	0.001
Trypanosoma cruzi	hypothetical protein	0.0016	0.004	0.0185
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0011	0.0015	0.5
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0011	0.0015	0.001
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1622	0.3481
Leishmania major	hypothetical protein, conserved	0.0306	0.1622	1
Leishmania major	cytochrome p450-like protein	0.0028	0.0108	0.0608
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Giardia lamblia	Zinc finger domain	0.0016	0.004	0.8799
Schistosoma mansoni	peter pan-related	0.0016	0.004	0.0064
Loa Loa (eye worm)	CYP4Cod1	0.0028	0.0108	0.0212
Leishmania major	protein kinase, putative	0.0012	0.0018	0.0051
Schistosoma mansoni	fusion	0.0306	0.1622	0.3481
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Schistosoma mansoni	hypothetical protein	0.0016	0.004	0.0064
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0016	0.004	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0016	0.004	0.0064
Echinococcus granulosus	Zinc finger RanBP2 type	0.0306	0.1622	0.1614
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0018	0.0018
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0108	0.0212
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0306	0.1622	0.1614
Echinococcus granulosus	ring finger protein 113a	0.0016	0.004	0.003
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0011	0.0015	0.001
Brugia malayi	hypothetical protein	0.0016	0.004	0.0064
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0016	0.0045	0.0035
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0306	0.1622	0.1614
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0011	0.0015	0.003
Chlamydia trachomatis	SWIB complex protein	0.086	0.4642	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.086	0.4642	1
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0011	0.0015	0.0005
Trypanosoma brucei	cAMP response protein 1, putative	0.0011	0.0015	0.0091
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0016	0.004	0.0054
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Trypanosoma brucei	protein kinase A regulatory subunit	0.0011	0.0015	0.0091
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0011	0.0015	0.001
Echinococcus granulosus	voltage gated potassium channel	0.0024	0.0086	0.0076
Trypanosoma cruzi	hypothetical protein, conserved	0.0306	0.1622	1
Trypanosoma brucei	Flagellar Member 6	0.0011	0.0015	0.0091
Leishmania major	protein kinase, putative	0.0012	0.0018	0.0051
Loa Loa (eye worm)	RING finger protein 20	0.0016	0.004	0.0064
Brugia malayi	YY1-associated factor 2	0.0306	0.1622	0.3481
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0011	0.0015	0.001
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Brugia malayi	hypothetical protein	0.0016	0.004	0.0064
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0016	0.0045	0.0075
Brugia malayi	B-box zinc finger family protein	0.0016	0.004	0.0064
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0011	0.0015	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.004	0.0185
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0306	0.1622	0.3481
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0016	0.004	0.0064
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Schistosoma mansoni	zinc finger protein	0.0016	0.004	0.0064
Onchocerca volvulus	Protein neuralized homolog	0.0016	0.004	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0011	0.0015	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0011	0.0015	0.001
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Leishmania major	hypothetical protein, conserved	0.0306	0.1622	1
Onchocerca volvulus		0.0306	0.1622	0.3481
Trichomonas vaginalis	ankyrin, putative	0.0016	0.004	0.0064
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0306	0.1622	0.3481
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0011	0.0015	0.001
Echinococcus multilocularis	SWI:SNF matrix associated	0.086	0.4642	0.4637
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.086	0.4642	1
Schistosoma mansoni	hypothetical protein	0.086	0.4642	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Brugia malayi	hypothetical protein	0.0016	0.004	0.0064
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Onchocerca volvulus		0.0016	0.004	0.0064
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0026	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Echinococcus granulosus	ring and YY1 binding protein	0.0306	0.1622	0.1614
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.0045	0.0075
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Onchocerca volvulus		0.0016	0.004	0.0064
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0011	0.0015	0.001
Echinococcus granulosus	cGMP dependent protein kinase	0.0012	0.0018	0.0008
Leishmania major	hypothetical protein, conserved	0.0306	0.1622	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0011	0.0015	0.001
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0016	0.004	0.0064
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0016	0.004	0.0245
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0306	0.1622	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0028	0.0108	1
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0011	0.0015	0.0091
Schistosoma mansoni	TRABID protein (C64 family)	0.0306	0.1622	0.3481
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0108	0.0608
Onchocerca volvulus		0.0011	0.0015	0.001
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0011	0.0015	0.0005
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0306	0.1622	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0011	0.0015	0.5
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0016	0.004	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0011	0.0015	0.001
Onchocerca volvulus		0.0306	0.1622	0.3481
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Giardia lamblia	Hypothetical protein	0.0016	0.004	0.8799
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0306	0.1622	1
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0016	0.004	0.0064
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0011	0.0015	0.0005
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0016	0.004	0.0064
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0086	0.0165
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0024	0.0086	0.0165
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0016	0.004	0.0064
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0011	0.0015	0.5
Schistosoma mansoni	mind bomb	0.0016	0.004	0.0064
Chlamydia trachomatis	DNA topoisomerase I	0.086	0.4642	1
Brugia malayi	Zinc finger, C2H2 type family protein	0.0016	0.004	0.0064
Trichomonas vaginalis	hypothetical protein	0.0016	0.004	0.0064
Echinococcus multilocularis	RING finger protein 185	0.0016	0.004	0.003
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Schistosoma mansoni	zinc finger protein	0.0306	0.1622	0.3481
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.004	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0237	0.1245	0.1236
Trichomonas vaginalis	conserved hypothetical protein	0.086	0.4642	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0108	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0012	0.0018	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0012	0.0018	0.0018
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0011	0.0015	0.001
Brugia malayi	Egg laying defective protein 4	0.0012	0.0018	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Plasmodium falciparum	cGMP-dependent protein kinase	0.0012	0.0018	0.0018
Onchocerca volvulus		0.0011	0.0015	0.001
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.086	0.4642	0.4637
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0016	0.004	0.0064
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.086	0.4642	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Onchocerca volvulus		0.027	0.1425	0.3055
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.0045	0.0075
Echinococcus granulosus	SWI:SNF matrix associated	0.086	0.4642	0.4637
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.086	0.4642	1
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Onchocerca volvulus	RING finger protein 141 homolog	0.0016	0.004	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0016	0.0045	0.0035
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0016	0.004	0.0064
Toxoplasma gondii	RING zinc finger protein	0.0016	0.004	0.0054
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0016	0.0045	0.0035
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0011	0.0015	0.0005
Leishmania major	hypothetical protein, conserved	0.0306	0.1622	1
Leishmania major	protein kinase A regulatory subunit, putative	0.0011	0.0015	0.003
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Leishmania major	hypothetical protein, unknown function	0.0011	0.0015	0.003
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0238	0.1253	0.1245
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0016	0.004	0.0064
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0016	0.004	0.003
Plasmodium vivax	hypothetical protein, conserved	0.086	0.4642	1
Treponema pallidum	cyclic nucleotide binding protein	0.0011	0.0015	0.5
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Loa Loa (eye worm)	hypothetical protein	0.0016	0.004	0.0064
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0043	0.0072
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Schistosoma mansoni	peter pan-related	0.0016	0.004	0.0064
Trichomonas vaginalis	ankyrin, putative	0.0016	0.004	0.0064
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0011	0.0015	0.003
Trypanosoma cruzi	hypothetical protein	0.0016	0.004	0.0185
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0016	0.0045	0.0035
Onchocerca volvulus	Putative RING finger protein 207	0.0016	0.004	0.0064
Echinococcus granulosus	ring finger protein 170	0.0016	0.004	0.003
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0306	0.1622	1
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0108	0.0608
Brugia malayi	Neuralized family protein	0.0016	0.004	0.0064
Giardia lamblia	Hypothetical protein	0.0016	0.004	0.8799
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.0045	0.0075
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.086	0.4642	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0011	0.0015	0.5
Giardia lamblia	Hypothetical protein	0.0016	0.004	0.8799
Entamoeba histolytica	zinc finger domain containing protein	0.0016	0.004	1
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0016	0.004	0.003
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Schistosoma mansoni	brg-1 associated factor	0.086	0.4642	1
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0045	0.0075
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.0379	0.0796
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0024	0.0086	0.0076
Toxoplasma gondii	hypothetical protein	0.0016	0.004	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Loa Loa (eye worm)	hypothetical protein	0.027	0.1425	0.3055
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0016	0.004	0.0185
Echinococcus granulosus	hyperpolarization activated cyclic	0.0016	0.0045	0.0035
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0016	0.004	0.003
Schistosoma mansoni	60S ribosomal protein L21	0.0013	0.0026	0.0036
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0011	0.0015	0.003
Onchocerca volvulus		0.0306	0.1622	0.3481
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0011	0.0015	0.001
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Trypanosoma cruzi	hypothetical protein, conserved	0.0306	0.1622	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0064	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0018	0.0018
Onchocerca volvulus		0.0016	0.004	0.0064
Schistosoma mansoni	hypothetical protein	0.0016	0.004	0.0064
Giardia lamblia	Ser/Thr protein kinase	0.0016	0.004	0.8799
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0016	0.004	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0015	0.001
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0016	0.004	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0018	0.0018
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0012	0.0018	0.0008
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0011	0.0015	0.001
Trypanosoma cruzi	WLM domain containing protein, putative	0.0306	0.1622	1
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0011	0.0015	0.001
Leishmania major	hypothetical protein, conserved	0.0306	0.1622	1
Trypanosoma brucei	hypothetical protein, conserved	0.0306	0.1622	1
Giardia lamblia	Zinc finger domain	0.0016	0.004	0.8799
Treponema pallidum	cyclic nucleotide binding protein	0.0011	0.0015	0.5
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0016	0.004	0.0245
Echinococcus multilocularis		0.0016	0.004	0.003
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0016	0.004	0.0064
Schistosoma mansoni	hypothetical protein	0.086	0.4642	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0011	0.0015	0.5
Brugia malayi	RING zinc finger protein	0.0016	0.004	0.0064
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0016	0.0045	0.0035
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0016	0.0045	0.0035
Brugia malayi	SWIB/MDM2 domain containing protein	0.086	0.4642	1
Trypanosoma brucei	Rab-like 5, small G protein	0.001	0.001	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Giardia lamblia	Kinase, NEK	0.0016	0.0043	1
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0016	0.004	0.0054
Schistosoma mansoni	hypothetical protein	0.0016	0.004	0.0064
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0011	0.0015	0.0005
Onchocerca volvulus		0.0306	0.1622	0.3481
Entamoeba histolytica	hypothetical protein	0.0016	0.004	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0306	0.1622	1
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0011	0.0015	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0349	0.0731
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0306	0.1622	1
Entamoeba histolytica	hypothetical protein	0.0016	0.004	1
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0011	0.0015	0.001
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.004	0.0185
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0016	0.004	0.0064
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0011	0.0015	0.001
Echinococcus multilocularis	zinc finger protein Ran binding	0.0306	0.1622	0.1614
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Giardia lamblia	Hypothetical protein	0.0016	0.004	0.8799
Trypanosoma cruzi	Flagellar Member 6	0.0011	0.0015	0.003
Echinococcus granulosus	zinc finger protein Ran binding	0.0306	0.1622	0.1614
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.086	0.4642	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Loa Loa (eye worm)	RiNg Finger protein family member	0.0016	0.004	0.0064
Echinococcus multilocularis	SWI:SNF matrix associated	0.086	0.4642	0.4637
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Leishmania major	hypothetical protein, conserved	0.0016	0.004	0.0185
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0016	0.0045	0.0075
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0016	0.0045	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.001
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0011	0.0015	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.004	0.0185
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.004	0.0064
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0306	0.1622	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0306	0.1622	0.1614
Giardia lamblia	Hypothetical protein	0.0016	0.004	0.8799
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.001
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0012	0.0018	0.0008
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Plasmodium falciparum	trophozoite exported protein 1	0.0016	0.004	0.0064
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0086	0.0165
Toxoplasma gondii	hypothetical protein	0.0016	0.004	0.0054
Giardia lamblia	Protein 21.1	0.0016	0.004	0.8799
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0245
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0011	0.0015	0.001
Toxoplasma gondii	ran binding protein	0.0306	0.1622	0.3474
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0011	0.0015	0.001
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0011	0.0015	0.5
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0016	0.004	0.0185

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.02 nM	Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting	ChEMBL.	22189275
IC50 (binding)	= 0.052 nM	Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting	ChEMBL.	22189275

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1951810

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1614888