Detailed information for compound 162006

Basic information

Technical information
  • TDR Targets ID: 162006
  • Name: (2S)-2-[[(2R)-2-[[2-[[(4R)-4-[[(2S,3S,4E,6E,8 S,9S)-3-acetamido-9-methoxy-2,6,8-trimethyl-1 0-phenyldeca-4,6-dienoyl]amino]-5-hydroxy-5-o xopentanoyl]-methylamino]acetyl]amino]propano yl]amino]-4-methylpentanoic acid
  • MW: 757.913 | Formula: C39H59N5O10
  • H donors: 6 H acceptors: 9 LogP: 3.46 Rotable bonds: 28
    Rule of 5 violations (Lipinski): 3
  • SMILES: CO[C@H]([C@H](/C=C(/C=C/[C@@H]([C@@H](C(=O)N[C@@H](C(=O)O)CCC(=O)N(CC(=O)N[C@@H](C(=O)N[C@H](C(=O)O)CC(C)C)C)C)C)NC(=O)C)\C)C)Cc1ccccc1
  • InChi: 1S/C39H59N5O10/c1-23(2)19-32(39(52)53)43-37(49)27(6)40-34(46)22-44(8)35(47)18-17-31(38(50)51)42-36(48)26(5)30(41-28(7)45)16-15-24(3)20-25(4)33(54-9)21-29-13-11-10-12-14-29/h10-16,20,23,25-27,30-33H,17-19,21-22H2,1-9H3,(H,40,46)(H,41,45)(H,42,48)(H,43,49)(H,50,51)(H,52,53)/b16-15+,24-20+/t25-,26-,27+,30-,31+,32-,33-/m0/s1
  • InChiKey: ZRRXSNWIIULVFK-ZWXWNXNYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[[(2R)-2-[[2-[[(4R)-4-[[(2S,3S,4E,6E,8S,9S)-3-acetamido-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoyl]amino]-5-hydroxy-5-oxo-pentanoyl]-methyl-amino]acetyl]amino]propanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2R)-2-[[2-[[(4R)-4-[[(2S,3S,4E,6E,8S,9S)-3-acetamido-9-methoxy-2,6,8-trimethyl-1-oxo-10-phenyldeca-4,6-dienyl]amino]-5-hydroxy-1,5-dioxopentyl]-methylamino]-1-oxoethyl]amino]-1-oxopropyl]amino]-4-methylpentanoic acid
  • (2S)-2-[[(2R)-2-[2-[[(4R)-4-[[(2S,3S,4E,6E,8S,9S)-3-acetamido-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoyl]amino]-5-hydroxy-5-oxo-pentanoyl]-methyl-amino]ethanoylamino]propanoyl]amino]-4-methyl-pentanoic acid
  • (2S)-2-[[(2R)-2-[[2-[[(4R)-4-[[(2S,3S,4E,6E,8S,9S)-3-acetamido-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoyl]amino]-5-hydroxy-5-keto-pentanoyl]-methyl-amino]acetyl]amino]propanoyl]amino]-4-methyl-valeric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Gallus gallus Serine-threonine protein phosphatase 2A regulatory subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma brucei protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Giardia lamblia Protein phosphatase PP2A regulatory subunit B Get druggable targets OG5_126981 All targets in OG5_126981
Trichomonas vaginalis serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania major hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Schistosoma mansoni protein phosphatase pp2a regulatory subunit B Get druggable targets OG5_126981 All targets in OG5_126981
Candida albicans subunit of protein phosphatase 2A Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Brugia malayi serine/threonine protein phosphatase 2A Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania infantum protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania donovani protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Trichomonas vaginalis protein phosphatase pp2a regulatory subunit B, putative Get druggable targets OG5_126981 All targets in OG5_126981
Candida albicans subunit of protein phosphatase 2A Get druggable targets OG5_126981 All targets in OG5_126981
Entamoeba histolytica protein phosphatase regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Echinococcus multilocularis protein phosphatase pp2a regulatory subunit b Get druggable targets OG5_126981 All targets in OG5_126981
Echinococcus granulosus protein phosphatase pp2a regulatory subunit b Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma brucei gambiense protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Schistosoma japonicum similar to Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, putative Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma congolense protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Onchocerca volvulus Protein phosphatase PP2A 55 kDa regulatory subunit homolog Get druggable targets OG5_126981 All targets in OG5_126981
Loa Loa (eye worm) serine/threonine protein phosphatase 2A Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania mexicana protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania braziliensis protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania donovani hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
Trichomonas vaginalis protein phosphatase PP2A regulatory subunit B, putative Get druggable targets OG5_126981 All targets in OG5_126981
Leishmania major protein phosphatase 2A regulatory subunit, putative Get druggable targets OG5_126981 All targets in OG5_126981
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_126981 All targets in OG5_126981
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni protein phosphatase 2a regulatory subunit Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 350 aa 38.9 %
Schistosoma japonicum similar to Protein phosphatase PP2A 55 kDa regulatory subunit, putative Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 353 aa 37.4 %
Schistosoma mansoni protein phosphatase pp2a regulatory subunit B Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 350 aa 38.9 %
Schistosoma japonicum ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 468 aa 45.7 %
Dictyostelium discoideum hypothetical protein Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 366 aa 31.7 %
Echinococcus multilocularis cleavage stimulation factor subunit 1 Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 364 aa 19.5 %
Echinococcus granulosus cleavage stimulation factor subunit 1 Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 364 aa 19.5 %
Onchocerca volvulus Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 355 aa 22.5 %
Onchocerca volvulus Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 444 aa 65.5 %
Brugia malayi Protein kinase domain containing protein Serine-threonine protein phosphatase 2A regulatory subunit   426 aa 474 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0055 0.0815
Brugia malayi ecdysteroid receptor 0.0038 0.0088 0.0238
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0069 0.0618
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0055 0.0815
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.022
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0059 0.0177
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0088 0.0079
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0101 0.0334 0.0773
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Brugia malayi Pre-SET motif family protein 0.0124 0.0425 0.126
Echinococcus granulosus expressed protein 0.0776 0.2981 0.2974
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0085 0.0076
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0095 0.0288
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0059 0.0049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0213 0.0492
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0009 0.0021
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0038 0.0402
Brugia malayi nuclear receptor RXR 0.0018 0.0009 0.0001
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0095 0.0086
Onchocerca volvulus 0.0048 0.0126 0.031
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1168 0.4515 0.451
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.026 0.0956 0.0948
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0425 0.0982
Entamoeba histolytica hypothetical protein 0.004 0.0097 0.2631
Entamoeba histolytica hypothetical protein 0.004 0.0095 0.2592
Toxoplasma gondii aldehyde dehydrogenase 0.026 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.0872 0.2632
Entamoeba histolytica elongation factor-2 kinase, putative 0.0048 0.0126 0.3425
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0097 0.0223
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0048 0.0126 0.1317
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0088 0.0079
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0096 0.0087
Schistosoma mansoni zinc finger protein 0.0018 0.0009 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0088 0.0238
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0368 0.0359
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0085 0.0201
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0368 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0032 0.0097
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0059 0.0049
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0055 0.0574
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.005 0.0682
Schistosoma mansoni lipoxygenase 0.0021 0.0022 0.0051
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0022 0.0134
Schistosoma mansoni lipoxygenase 0.0059 0.0171 0.0396
Onchocerca volvulus 0.0124 0.0425 0.1104
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0122
Trichomonas vaginalis protein phosphatase pp2a regulatory subunit B, putative 0.0074 0.0228 0.058
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0085 0.3469
Echinococcus granulosus slit 2 protein 0.0024 0.0033 0.0024
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0095 0.0261
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0055 0.0122
Brugia malayi ecdysone receptor 0.0018 0.0009 0.0001
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0074 0.023 0.0221
Brugia malayi intermediate filament protein 0.0085 0.0273 0.0799
Loa Loa (eye worm) hypothetical protein 0.0084 0.0267 0.0805
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0088 0.0079
Plasmodium vivax SET domain protein, putative 0.0124 0.0425 1
Echinococcus granulosus geminin 0.0182 0.0652 0.0643
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0299
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0033 0.01
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0164 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0088 0.0265
Onchocerca volvulus 0.098 0.3777 1
Schistosoma mansoni rab6-interacting 0.0021 0.0022 0.0051
Brugia malayi hypothetical protein 0.004 0.0095 0.0261
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0368 0.0952
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Onchocerca volvulus 0.0021 0.0022 0.0034
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0028 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0088 0.0238
Onchocerca volvulus 0.0049 0.0129 0.0319
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Brugia malayi hypothetical protein 0.0028 0.005 0.0123
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0368 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0088 0.0238
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0069 0.0401
Schistosoma mansoni hypothetical protein 0.0439 0.1659 0.3834
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0049 0.0113
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0088 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0088 0.0265
Onchocerca volvulus 0.0018 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0288
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0164 0.3583
Loa Loa (eye worm) hypothetical protein 0.0055 0.0156 0.047
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0088 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0088 0.0079
Loa Loa (eye worm) glutamate receptor 0.0089 0.0287 0.0866
Schistosoma mansoni ap endonuclease 0.0057 0.0164 0.0378
Onchocerca volvulus 0.0048 0.0126 0.031
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0076 0.0797
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.005 0.1347
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0028 0.0085
Echinococcus granulosus dnaJ subfamily B 0.0439 0.1659 0.1652
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.0612
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0164 0.041
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0088 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.008 0.0187
Onchocerca volvulus 0.0055 0.0156 0.0389
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Onchocerca volvulus 0.0048 0.0126 0.031
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0048 0.0126 0.2578
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0288
Brugia malayi 6-phosphofructokinase 0.0109 0.0368 0.1086
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Brugia malayi 6-phosphofructokinase 0.0109 0.0368 0.1086
Echinococcus multilocularis protein phosphatase pp2a regulatory subunit b 0.0074 0.0228 0.0219
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0122
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0009 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0088 0.0238
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0122
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0059 0.0049
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0048 0.0126 0.0117
Schistosoma mansoni DNA helicase recq5 0.003 0.0059 0.0135
Mycobacterium ulcerans hypothetical protein 0.0021 0.0022 0.0134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0164 0.4448
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.015
Entamoeba histolytica protein phosphatase regulatory subunit, putative 0.0074 0.0228 0.6194
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0076 0.084
Loa Loa (eye worm) hypothetical protein 0.0041 0.01 0.0302
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0249 0.0915 0.0906
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0028 0.0085
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0367 0.0358
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.022
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0273 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0017 0.0004 0.0009
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0095 0.0261
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0009 0.0001
Onchocerca volvulus 0.0048 0.0126 0.031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Schistosoma mansoni DNA helicase recq1 0.003 0.0059 0.0135
Schistosoma mansoni nuclear receptor 0.0018 0.0009 0.0021
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0033 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0048 0.0126 0.2578
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0228 0.5602
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0177
Echinococcus multilocularis lamin dm0 0.0085 0.0273 0.0264
Echinococcus granulosus metabotropic glutamate receptor 2 0.0074 0.023 0.0221
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.011 0.0306
Schistosoma mansoni slit 0.0024 0.0033 0.0077
Schistosoma mansoni hypothetical protein 0.0048 0.0126 0.0291
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0022 0.0013
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0009 0.0001
Brugia malayi hypothetical protein 0.0018 0.001 0.0004
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0088 0.0238
Giardia lamblia Protein phosphatase PP2A regulatory subunit B 0.0074 0.0228 1
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0033 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0088 0.0203
Schistosoma mansoni survival motor neuron protein 0.0049 0.0129 0.0299
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.0254 0.0742
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0872 0.0863
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.021 0.0485
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Schistosoma mansoni hypothetical protein 0.0276 0.102 0.2357
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0027
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0164 0.3511
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0009 0.0001
Entamoeba histolytica hypothetical protein 0.004 0.0097 0.2631
Trichomonas vaginalis rotamase, putative 0.0036 0.008 0.0187
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0022 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.021 0.5706
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0088 0.0238
Schistosoma mansoni metabotropic glutamate receptor 0.0074 0.023 0.0532
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0085 0.0196
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0097 0.0088
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Brugia malayi Metabotropic glutamate receptor precursor. 0.0089 0.0287 0.0841
Schistosoma mansoni lamin 0.0085 0.0273 0.063
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0009 0.0028
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0085 0.0196
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0088 0.0203
Schistosoma mansoni coup transcription factor 0.0038 0.0088 0.0203
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0095 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0088 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0088 0.0079
Loa Loa (eye worm) DR-78 0.0018 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0053
Schistosoma mansoni axis inhibition protein axin 0.004 0.0095 0.022
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0126 0.0354
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0095 0.0086
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0048 0.0126 0.038
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0085 0.2309
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0053
Loa Loa (eye worm) RGS-3 protein 0.004 0.0095 0.0288
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0018 0.0041
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0095 0.0086
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0164 0.0468
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0022 0.0134
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0253 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0088 0.0238
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.01 0.0091
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0129 0.0364
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0059 0.2265
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0171 0.0162
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0171 0.0162
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0085 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0956 0.221
Onchocerca volvulus 0.0018 0.0009 0.0001
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0085 0.0076
Echinococcus granulosus axis inhibition protein axin 0.004 0.0095 0.0086
Trichomonas vaginalis rotamase, putative 0.0035 0.0076 0.0178
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0126 0.3425
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0055 0.0574
Brugia malayi nuclear receptor NHR-88 0.0038 0.0088 0.0238
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0048 0.0126 0.038
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0095 0.022
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0186 0.1942
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0085 0.0201
Entamoeba histolytica recQ family helicase, putative 0.0033 0.0069 0.1882
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0156 0.036
Loa Loa (eye worm) RecQ helicase 0.0044 0.011 0.0332
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0085 0.0571
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0095 0.0086
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0088 0.0209
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0018 0.0008
Leishmania major hypothetical protein, conserved 0.0028 0.005 0.0188
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0095 0.0086
Brugia malayi CXXC zinc finger family protein 0.0031 0.006 0.0154
Schistosoma mansoni hypothetical protein 0.0182 0.0652 0.1506
Brugia malayi von Willebrand Factor 0.0048 0.0126 0.0354
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0067
Brugia malayi PXA domain containing protein 0.004 0.0095 0.0261
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0059 0.158
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0368 0.0952
Loa Loa (eye worm) CUTiclin family member 0.0048 0.0126 0.038
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0095 0.022
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0288
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0088 0.0203
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0088 0.0203
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0273 0.0799
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.026 0.0956 0.0948
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0018 0.0041
Onchocerca volvulus 0.0048 0.0126 0.031
Chlamydia trachomatis endonuclease IV 0.008 0.0253 1
Trichomonas vaginalis protein phosphatase PP2A regulatory subunit B, putative 0.0074 0.0228 0.058
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0122
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0288
Brugia malayi steroid hormone receptor 0.0038 0.0088 0.0238
Toxoplasma gondii endonuclease IV APN 0.008 0.0253 0.265
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0956 0.221
Echinococcus multilocularis geminin 0.0182 0.0652 0.0643
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0368 1
Schistosoma mansoni rotamase 0.0036 0.008 0.0184
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0009 0.0001
Leishmania major protein phosphatase 2A regulatory subunit, putative 0.0074 0.0228 0.2116
Echinococcus granulosus bloom syndrome protein 0.0044 0.011 0.0101
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Brugia malayi hypothetical protein 0.0114 0.0388 0.1146
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0048 0.0126 0.031
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Schistosoma mansoni cpg binding protein 0.0033 0.0067 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0088 0.0238
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.021 0.1922
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0099 0.3341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0425 0.0982
Brugia malayi hypothetical protein 0.0238 0.0872 0.2611
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0069 0.1882
Brugia malayi PXA domain containing protein 0.004 0.0095 0.0261
Leishmania major hypothetical protein, conserved 0.0074 0.0228 0.2116
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0032 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0228 0.6194
Schistosoma mansoni polycystin 1-related 0.0021 0.0022 0.0051
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0076 0.2074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.0425 0.0416
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0076 0.2074
Schistosoma mansoni thyroid hormone receptor 0.0314 0.1169 0.2701
Entamoeba histolytica hypothetical protein 0.0048 0.0126 0.3425
Entamoeba histolytica hypothetical protein 0.004 0.0095 0.2592
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.005 0.1347
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.021 0.5037
Treponema pallidum 76K protein 0.0048 0.0126 0.0241
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0368 0.3786
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0022 0.0013
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0095 0.0261
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0009 0.0028
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0095 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0956 1
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0088 0.0203
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0164 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.021 0.0201
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0095 0.0086
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.011 0.0268
Onchocerca volvulus 0.0048 0.0126 0.031
Schistosoma mansoni cpg binding protein 0.0031 0.006 0.0138
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0009 0.0021
Onchocerca volvulus Protein phosphatase PP2A 55 kDa regulatory subunit homolog 0.0074 0.0228 0.058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0066
Brugia malayi Protein kinase domain containing protein 0.0024 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Onchocerca volvulus 0.0048 0.0126 0.031
Loa Loa (eye worm) hypothetical protein 0.0085 0.0273 0.0824
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.1659 0.1652
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.021 0.5706
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0095 0.0086
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.0069 0.016
Brugia malayi Doublecortin family protein 0.0021 0.0022 0.0039
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0085 0.0076
Onchocerca volvulus 0.0024 0.0032 0.0061
Brugia malayi hypothetical protein 0.002 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0284
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Plasmodium vivax thrombospondin-related anonymous protein 0.0048 0.0126 0.2578
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0088 0.0079
Echinococcus multilocularis expressed protein 0.0036 0.008 0.007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Trichomonas vaginalis serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative 0.0074 0.0228 0.058
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0288
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0861 0.3312 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0085
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0009 0.0021
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0033 0.0024
Schistosoma mansoni nuclear receptor 0.0018 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0124 0.0425 0.1284
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0088 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0088 0.0238
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0122
Brugia malayi nuclear receptor NHR-67 0.0018 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0055 0.142
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0085 0.1112
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0956 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0249 0.0915 0.2762
Mycobacterium ulcerans epimerase 0.0021 0.0022 0.0134
Schistosoma mansoni hypothetical protein 0.004 0.0097 0.0223
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0368 0.111
Schistosoma mansoni intermediate filament proteins 0.0085 0.0273 0.063
Loa Loa (eye worm) hypothetical protein 0.0109 0.0367 0.1108
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0253 0.074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0288
Entamoeba histolytica hypothetical protein 0.004 0.0097 0.2631
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0095 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0088 0.0079
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0088 0.0203
Brugia malayi hypothetical protein 0.002 0.0018 0.0026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0088 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0053
Echinococcus granulosus collagen alpha 1VII chain 0.0048 0.0126 0.0117
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0032 0.0336
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.01
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0126 0.2578
Entamoeba histolytica hypothetical protein 0.004 0.0095 0.2592
Schistosoma mansoni cell polarity protein 0.0024 0.0033 0.0077
Schistosoma mansoni rab6-interacting 0.0021 0.0022 0.0051
Brugia malayi laminin alpha chain 0.0024 0.0033 0.0073
Onchocerca volvulus 0.0021 0.0022 0.0034
Schistosoma mansoni hypothetical protein 0.0021 0.0022 0.0051
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Schistosoma mansoni axis inhibition protein axin 0.004 0.0095 0.022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0097 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0088 0.0265
Loa Loa (eye worm) hypothetical protein 0.008 0.0253 0.0765
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0022 0.0013
Echinococcus granulosus lamin 0.0085 0.0273 0.0264
Schistosoma mansoni hypothetical protein 0.0603 0.2302 0.532
Echinococcus granulosus cpg binding protein 0.0033 0.0067 0.0058
Echinococcus multilocularis slit 2 protein 0.0024 0.0033 0.0024
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0872 0.0863
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0118 0.0329
Brugia malayi Cache domain containing protein 0.0517 0.1965 0.5922
Echinococcus granulosus lamin dm0 0.0085 0.0273 0.0264
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0109 0.0251
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0055 0.142
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0085 0.0076
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0095 0.0086
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0033 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0088 0.0265
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0164 0.4448
Toxoplasma gondii microneme protein MIC2 0.0048 0.0126 0.1317
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Schistosoma mansoni serine-rich repeat protein 0.0603 0.2302 0.532
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0088 0.0079
Brugia malayi conserved hypotetical protein 0.0018 0.0009 0.0001
Brugia malayi phosphofructokinase 0.0109 0.0368 0.1086
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0085 0.0076
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0055 0.2096
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0088 0.0079
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.0872 0.2632
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1351 0.5234 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0118 0.0356
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0095 0.0086
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0095 0.0288
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.026 0.0956 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0273 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0088 0.0238
Echinococcus granulosus protein phosphatase pp2a regulatory subunit b 0.0074 0.0228 0.0219
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0048 0.0126 0.2578
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0095 0.0261
Brugia malayi hypothetical protein 0.0253 0.0931 0.2792
Schistosoma mansoni hypothetical protein 0.0048 0.0126 0.0291
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.015
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0095 0.0229
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0164 0.041
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0253 0.574
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0022 0.0013
Schistosoma mansoni ap endonuclease 0.0057 0.0164 0.0378
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0368 0.0952
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0018 0.0008
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0368 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0367 0.0358
Brugia malayi Pre-SET motif family protein 0.0861 0.3312 1
Loa Loa (eye worm) hypothetical protein 0.0517 0.1965 0.5933
Schistosoma mansoni cpg binding protein 0.0033 0.0067 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0425 0.0982
Treponema pallidum hypothetical protein 0.0048 0.0126 0.0241
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0048 0.0126 0.4491
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.021 0.5706
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0095 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0368 0.0952
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0249 0.0915 0.2113
Echinococcus multilocularis musashi 0.0085 0.0273 0.0264
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0164 0.0154
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0097
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0088 0.0209
Onchocerca volvulus 0.0031 0.006 0.0135
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0164 0.0154
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Schistosoma mansoni hypothetical protein 0.0024 0.0032 0.0074
Brugia malayi hypothetical protein 0.0018 0.0009 0.0001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0276 0.102 0.1012
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0284
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.01 0.0091
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0022 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.087 0.335 0.3344
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.015
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0126 0.0354
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0022 0.0038
Echinococcus multilocularis cpg binding protein 0.0033 0.0067 0.0058
Loa Loa (eye worm) serine/threonine protein phosphatase 2A 0.0074 0.0228 0.0688
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0095 0.0261
Trypanosoma brucei protein phosphatase 2A regulatory subunit, putative 0.0074 0.0228 0.5602
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0088 0.0079
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0088 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0018 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0314 0.1169 0.1161
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0055 0.1493
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0126 0.3425
Echinococcus granulosus transcription factor Dp 1 0.004 0.0096 0.0087
Schistosoma mansoni lamin 0.0085 0.0273 0.063
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0022 0.0067
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0009 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0088 0.0079
Brugia malayi follicle stimulating hormone receptor 0.0238 0.0872 0.2612
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0368 0.363
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0088 0.0079
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0164 0.7064
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0088 0.0203
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2568 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0022 0.0013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0088 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0088 0.0238
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0033 0.0077
Toxoplasma gondii exonuclease III APE 0.0057 0.0164 0.171
Echinococcus granulosus pikachurin 0.0024 0.0033 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0088 0.0238
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.021 0.0201
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0095 0.0086
Brugia malayi EGF-like domain containing protein 0.0024 0.0033 0.0073
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.0425 0.0416
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0228 0.6194
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0425 0.0982
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0032 0.0023
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0164 0.6116
Loa Loa (eye worm) glutamate receptor 0.0035 0.0076 0.0229
Brugia malayi hypothetical protein 0.0021 0.0022 0.0039
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0041 0.0465
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative 0.0074 0.0228 0.6194
Loa Loa (eye worm) hypothetical protein 0.066 0.2524 0.7622
Brugia malayi Kringle domain containing protein 0.0024 0.0032 0.007
Echinococcus granulosus RUN 0.0021 0.0022 0.0013
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.112 0.4328 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0368 0.3786
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.008 0.024
Echinococcus multilocularis bloom syndrome protein 0.0044 0.011 0.0101
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0033 0.0077
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0055 0.0574
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0126 0.0354
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0088 0.0238
Brugia malayi nuclear receptor RXR 0.002 0.0018 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0088 0.0265
Echinococcus granulosus expressed protein 0.0036 0.008 0.007
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0164 0.1422
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0368 0.0703
Brugia malayi nuclear receptor NHR-88 0.0018 0.0009 0.0001
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0109 0.0301
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0018 0.0053
Onchocerca volvulus 0.0085 0.0273 0.07
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.01
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0095 0.0288
Echinococcus multilocularis lamin 0.0085 0.0273 0.0264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0095 0.0261
Brugia malayi serine/threonine protein phosphatase 2A 0.0074 0.0228 0.0662
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0048 0.0126 0.0354
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.021 0.0608
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0164 0.1631
Schistosoma mansoni loxhd1 0.0021 0.0022 0.0051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0164 0.0494
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0095 0.0086
Brugia malayi hypothetical protein 0.0048 0.0126 0.0354
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0253 0.2579
Brugia malayi hypothetical protein 0.004 0.0097 0.0265
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0368 1
Brugia malayi Cytochrome P450 family protein 0.007 0.0213 0.0618
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0085 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0164 0.4448
Echinococcus granulosus leukotriene A 4 hydrolase 0.0249 0.0915 0.0906
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0368 1
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0253 0.6696
Brugia malayi hypothetical protein 0.004 0.0095 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0088 0.0265
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0368 0.085
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0095 0.0086
Echinococcus granulosus tumor protein p63 0.0378 0.1419 0.1412
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0368 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0095 0.022
Echinococcus multilocularis expressed protein 0.0776 0.2981 0.2974
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0368 0.111
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0088 0.0079
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.021 0.0633
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0126 0.0354
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0088 0.0238
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.006 0.0181
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0368 0.085
Plasmodium falciparum thrombospondin-related anonymous protein 0.0048 0.0126 0.4491
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0009 0.0021
Trypanosoma cruzi protein phosphatase 2A regulatory subunit, putative 0.0074 0.0228 0.6194
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0095 0.0288
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0059 0.0049
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0048 0.0126 0.4491
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.0612
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0085 0.2309
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0067
Brugia malayi tailless protein 0.0018 0.0009 0.0001
Schistosoma mansoni hypothetical protein 0.0182 0.0652 0.1506
Onchocerca volvulus 0.0038 0.0088 0.0209
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.011 0.0268
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.026 0.0956 1
Echinococcus multilocularis RUN 0.0021 0.0022 0.0013
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0032 0.0437
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0213 0.0643
Brugia malayi nuclear hormone receptor 0.0018 0.0009 0.0001
Brugia malayi hypothetical protein 0.0018 0.0009 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.005 0.1189
Brugia malayi nuclear hormone receptor 0.0038 0.0088 0.0238
Entamoeba histolytica hypothetical protein 0.004 0.0097 0.2631
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0009 0.0001
Echinococcus granulosus axis inhibition protein axin 0.004 0.0095 0.0086
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0368 0.111
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0276 0.102 0.1012
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0565 0.2152 0.4971
Echinococcus multilocularis pikachurin 0.0024 0.0033 0.0024
Loa Loa (eye worm) CUTiclin-Like family member 0.0048 0.0126 0.038
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.005 0.1189
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0032 0.0874
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0053
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.008 0.0214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.01
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.022
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0095 0.0086
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0265
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0018 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0314 0.1169 0.2701
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0164 0.1631
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0405 0.0396
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0076 0.2074
Echinococcus granulosus intermediate filament protein 0.0085 0.0273 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Echinococcus multilocularis tumor protein p63 0.0378 0.1419 0.1412
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0095 0.022
Onchocerca volvulus 0.0085 0.0273 0.07
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0088 0.0238
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.005 0.0518
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0425 0.0416
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0088 0.0265
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0256
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0009 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0425 0.4445
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0088 0.0265
Mycobacterium ulcerans endonuclease IV 0.008 0.0253 0.2579
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0095 0.022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0085 0.2309
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0085 0.0201
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0155
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0076 0.0477
Echinococcus granulosus voltage dependent calcium channel subunit 0.1168 0.4515 0.451
Loa Loa (eye worm) hypothetical protein 0.0048 0.0126 0.038
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0055 0.0105
Brugia malayi hypothetical protein 0.0021 0.0022 0.0039
Trichomonas vaginalis set domain proteins, putative 0.098 0.3777 1
Schistosoma mansoni protein phosphatase pp2a regulatory subunit B 0.0074 0.0228 0.0526

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 uM Inhibitory concentration of the compound required against protein phosphatase 2A using pNPP assay ChEMBL. 14611854
IC50 (binding) = 17 uM Inhibitory concentration of the compound required against protein phosphatase 2A using pNPP assay ChEMBL. 14611854
IC50 (binding) = 230 uM Inhibitory concentration of the compound required against protein phosphatase 1 using pNPP assay ChEMBL. 14611854
IC50 (binding) = 230 uM Inhibitory concentration of the compound required against protein phosphatase 1 using pNPP assay ChEMBL. 14611854
Ratio (binding) = 7.5 Ratio of IC50 of Protein phosphatase 1 to that of IC50 of Protein phosphatase 2A ChEMBL. 14611854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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