Detailed information for compound 163419

Basic information

Technical information
  • TDR Targets ID: 163419
  • Name: N-hydroxy-N-phenylbenzenesulfonamide
  • MW: 249.286 | Formula: C12H11NO3S
  • H donors: 1 H acceptors: 3 LogP: 2.14 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON(S(=O)(=O)c1ccccc1)c1ccccc1
  • InChi: 1S/C12H11NO3S/c14-13(11-7-3-1-4-8-11)17(15,16)12-9-5-2-6-10-12/h1-10,14H
  • InChiKey: GIRGWRZFFZOIBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-hydroxy-N-phenyl-benzenesulfonamide
  • 7340-50-3
  • 4-15-00-00011 (Beilstein Handbook Reference)
  • BRN 2653292
  • Benzenesulfonanilide, N-hydroxy-
  • N-Hydroxyphenylbenzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Aldehyde dehydrogenase 1A1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 462 aa 32.3 %
Brugia malayi aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 469 aa 37.3 %
Candida albicans cytosolic acetaldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 481 aa 30.4 %
Schistosoma japonicum ko:K00139 succinate-semialdehyde dehydrogenase [EC1.2.1.24], putative Aldehyde dehydrogenase 1A1   501 aa 497 aa 33.4 %
Candida albicans delta-1-pyrroline-5-carboxylate dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 463 aa 28.5 %
Leishmania infantum aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 478 aa 36.0 %
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd Aldehyde dehydrogenase 1A1   501 aa 480 aa 29.0 %
Leishmania mexicana delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 450 aa 26.2 %
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA Aldehyde dehydrogenase 1A1   501 aa 492 aa 27.0 %
Leishmania donovani aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 468 aa 29.7 %
Dictyostelium discoideum hypothetical protein Aldehyde dehydrogenase 1A1   501 aa 436 aa 26.8 %
Drosophila melanogaster CG8665 gene product from transcript CG8665-RA Aldehyde dehydrogenase 1A1   501 aa 482 aa 48.3 %
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA Aldehyde dehydrogenase 1A1   501 aa 486 aa 27.2 %
Trypanosoma brucei aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 439 aa 33.5 %
Trypanosoma cruzi aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 479 aa 38.0 %
Schistosoma mansoni succinate semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 503 aa 36.4 %
Dictyostelium discoideum aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 488 aa 28.3 %
Leishmania mexicana aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 468 aa 29.7 %
Leishmania infantum aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 468 aa 29.7 %
Candida albicans succinate-semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 490 aa 39.2 %
Onchocerca volvulus Aldehyde dehydrogenase 1A1   501 aa 479 aa 39.2 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 Aldehyde dehydrogenase 1A1   501 aa 456 aa 33.3 %
Leishmania donovani delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 452 aa 26.3 %
Trypanosoma brucei gambiense aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 439 aa 33.3 %
Loa Loa (eye worm) aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 481 aa 37.4 %
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Aldehyde dehydrogenase 1A1   501 aa 484 aa 24.2 %
Candida albicans cytosolic acetaldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 481 aa 30.4 %
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Aldehyde dehydrogenase 1A1   501 aa 466 aa 37.1 %
Leishmania braziliensis aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 438 aa 32.4 %
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA Aldehyde dehydrogenase 1A1   501 aa 489 aa 32.7 %
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 453 aa 27.2 %
Candida albicans delta-1-pyrroline-5-carboxylate dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 463 aa 28.5 %
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent Aldehyde dehydrogenase 1A1   501 aa 465 aa 30.3 %
Candida albicans similarity to aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 471 aa 25.9 %
Trypanosoma brucei gambiense aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 471 aa 35.9 %
Trypanosoma brucei aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 471 aa 35.7 %
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 452 aa 26.5 %
Trypanosoma congolense aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 481 aa 35.1 %
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 465 aa 30.3 %
Leishmania mexicana aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 472 aa 36.4 %
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 Aldehyde dehydrogenase 1A1   501 aa 464 aa 35.1 %
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 450 aa 26.2 %
Trypanosoma cruzi aldehyde dehydrogenase family, putative Aldehyde dehydrogenase 1A1   501 aa 423 aa 27.7 %
Leishmania braziliensis aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 471 aa 29.9 %
Dictyostelium discoideum aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 467 aa 33.2 %
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 532 aa 32.9 %
Leishmania major aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 466 aa 29.6 %
Leishmania infantum aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 462 aa 32.3 %
Leishmania infantum delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 450 aa 26.0 %
Leishmania braziliensis delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 452 aa 27.4 %
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 456 aa 27.4 %
Leishmania donovani aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 478 aa 36.0 %
Onchocerca volvulus Testis-specific serine\/threonine-protein kinase 3 homolog Aldehyde dehydrogenase 1A1   501 aa 440 aa 27.5 %
Echinococcus granulosus succinate semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 482 aa 37.3 %
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 457 aa 32.6 %
Candida albicans succinate-semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 490 aa 39.2 %
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 Aldehyde dehydrogenase 1A1   501 aa 457 aa 33.0 %
Onchocerca volvulus Aldehyde dehydrogenase 1A1   501 aa 472 aa 38.8 %
Leishmania braziliensis aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 472 aa 36.4 %
Schistosoma mansoni aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 431 aa 28.1 %
Trypanosoma cruzi aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 465 aa 31.6 %
Schistosoma japonicum ko:K00294 1-pyrroline-5-carboxylate dehydrogenase [EC1.5.1.12], putative Aldehyde dehydrogenase 1A1   501 aa 426 aa 28.2 %
Echinococcus multilocularis succinate semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 484 aa 37.6 %
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) Aldehyde dehydrogenase 1A1   501 aa 500 aa 31.0 %
Leishmania mexicana aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 491 aa 32.6 %
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 Aldehyde dehydrogenase 1A1   501 aa 480 aa 32.3 %
Dictyostelium discoideum methylmalonate-semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 496 aa 32.1 %
Drosophila melanogaster CG9629 gene product from transcript CG9629-RA Aldehyde dehydrogenase 1A1   501 aa 473 aa 27.1 %
Leishmania major aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 478 aa 36.0 %
Drosophila melanogaster Succinic semialdehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 479 aa 37.2 %
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative Aldehyde dehydrogenase 1A1   501 aa 500 aa 28.0 %
Leishmania major aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 439 aa 32.8 %
Neospora caninum aldehyde dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 501 aa 22.0 %
Schistosoma mansoni hypothetical protein Aldehyde dehydrogenase 1A1   501 aa 477 aa 34.8 %
Candida albicans similarity to aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 471 aa 25.9 %
Dictyostelium discoideum aldehyde dehydrogenase Aldehyde dehydrogenase 1A1   501 aa 467 aa 30.0 %
Trypanosoma brucei gambiense delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 453 aa 26.9 %
Trypanosoma congolense delta-1-pyrroline-5-carboxylate dehydrogenase, putative Aldehyde dehydrogenase 1A1   501 aa 453 aa 28.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK protein kinase 0.035 0.2387 0.3236
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.035 0.2387 0.3236
Schistosoma mansoni cell adhesion molecule 0.0435 0.4258 0.5079
Trypanosoma cruzi hypothetical protein, conserved 0.0277 0.0771 0.5
Echinococcus granulosus Netrin receptor DCC 0.0277 0.0771 0.0373
Echinococcus granulosus nephrin 0.035 0.2387 0.2059
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0277 0.0771 0.0373
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0435 0.4258 0.6305
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0277 0.0771 0.0373
Echinococcus granulosus G1Y162 protein 0.0277 0.0771 0.0373
Echinococcus granulosus Netrin receptor DCC 0.0277 0.0771 0.0373
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Echinococcus multilocularis anosmin 1 0.0277 0.0771 0.0373
Schistosoma mansoni myosin-binding protein-related 0.035 0.2387 0.2847
Echinococcus granulosus neuroglian 0.0334 0.2029 0.1686
Schistosoma mansoni hypothetical protein 0.035 0.2387 0.2847
Loa Loa (eye worm) hypothetical protein 0.0346 0.2285 0.3069
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.035 0.2387 0.2059
Echinococcus granulosus fibronectin type III domain-containing protein 0.0277 0.0771 0.0373
Loa Loa (eye worm) hypothetical protein 0.0419 0.3901 0.5719
Echinococcus multilocularis roundabout 2 0.0435 0.4258 0.4011
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.035 0.2387 0.3236
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0277 0.0771 0.0373
Brugia malayi Immunoglobulin I-set domain containing protein 0.0435 0.4258 0.6075
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0277 0.0771 0.0373
Schistosoma mansoni cell adhesion molecule 0.0623 0.8384 1
Echinococcus multilocularis transfer RNA-Phe 0.035 0.2387 0.2059
Schistosoma mansoni titin 0.0277 0.0771 0.0919
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0277 0.0771 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.035 0.2387 0.2847
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.2387 0.2815
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0362 0.2642 0.2325
Schistosoma mansoni factor for adipocyte differentiation 0.0277 0.0771 0.0919
Schistosoma mansoni hypothetical protein 0.0277 0.0771 0.0919
Schistosoma mansoni protein tyrosine phosphatase 0.0277 0.0771 0.0919
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0361 0.2611 0.2293
Echinococcus multilocularis anosmin 1 0.0277 0.0771 0.0373
Brugia malayi hypothetical protein 0.0538 0.6512 1
Schistosoma mansoni nephrin 0.0435 0.4258 0.5079
Schistosoma mansoni factor for adipocyte differentiation 0.0277 0.0771 0.0919
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Loa Loa (eye worm) hypothetical protein 0.035 0.2387 0.3236
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Echinococcus granulosus Fibronectin type III domain containing protein 0.0277 0.0771 0.0373
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0277 0.0771 0.0919
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0277 0.0771 0.0919
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Echinococcus granulosus titin 0.035 0.2387 0.2059
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Onchocerca volvulus 0.035 0.2387 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.4258 0.6305
Echinococcus granulosus contactin 0.0435 0.4258 0.4011
Echinococcus multilocularis cell adhesion molecule 0.0277 0.0771 0.0373
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.2387 0.2815
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.2387 0.2815
Echinococcus multilocularis titin 0.0277 0.0771 0.0373
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0277 0.0771 0.0373
Echinococcus granulosus anosmin 1 0.0277 0.0771 0.0373
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0261 0.0413 0.0493
Schistosoma mansoni cell adhesion molecule 0.035 0.2387 0.2847
Echinococcus multilocularis neuroglian 0.0435 0.4258 0.4011
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0435 0.4258 0.4011
Echinococcus multilocularis Netrin receptor DCC 0.0277 0.0771 0.0373
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0277 0.0771 0.5
Schistosoma mansoni hypothetical protein 0.0277 0.0771 0.0919
Loa Loa (eye worm) hypothetical protein 0.0538 0.6512 1
Echinococcus granulosus twitchin 0.0334 0.2029 0.1686
Loa Loa (eye worm) hypothetical protein 0.0419 0.3901 0.5719
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.035 0.2387 0.3236
Echinococcus granulosus neuroglian 0.0435 0.4258 0.4011
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0277 0.0771 0.0586
Schistosoma mansoni cell adhesion molecule 0.035 0.2387 0.2847
Schistosoma mansoni nephrin 0.0611 0.8128 0.9695
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0429 0.4126 0.6087
Echinococcus granulosus cell adhesion molecule 0.0277 0.0771 0.0373
Onchocerca volvulus 0.035 0.2387 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0277 0.0771 0.0373
Echinococcus granulosus roundabout 2 0.0435 0.4258 0.4011
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0435 0.4258 0.4011
Schistosoma mansoni factor for adipocyte differentiation 0.0277 0.0771 0.0919
Echinococcus multilocularis anosmin 1 0.0277 0.0771 0.0373
Brugia malayi protein unc-22 0.035 0.2387 0.2815
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0435 0.4258 0.4011
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0277 0.0771 0.0373
Loa Loa (eye worm) myotactin form A 0.0277 0.0771 0.0586
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Brugia malayi Immunoglobulin I-set domain containing protein 0.0538 0.6512 1
Schistosoma mansoni ephrin receptor 0.0361 0.2611 0.3115
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.2642 0.326
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0277 0.0771 0.0586
Brugia malayi Immunoglobulin I-set domain containing protein 0.0435 0.4258 0.6075
Echinococcus multilocularis roundabout 2 0.0696 1 1
Echinococcus granulosus titin 0.035 0.2387 0.2059
Echinococcus granulosus anosmin 1 0.0277 0.0771 0.0373
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0277 0.0771 0.0586
Schistosoma mansoni neuroglian 0.0435 0.4258 0.5079
Echinococcus granulosus anosmin 1 0.0277 0.0771 0.0373
Echinococcus granulosus Fibronectin type III 0.0277 0.0771 0.0373
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.2387 0.2815
Loa Loa (eye worm) hypothetical protein 0.0538 0.6512 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.035 0.2387 0.3236
Loa Loa (eye worm) hypothetical protein 0.0538 0.6512 1
Echinococcus granulosus usherin 0.0277 0.0771 0.0373
Brugia malayi Immunoglobulin I-set domain containing protein 0.0429 0.4126 0.5843
Echinococcus multilocularis roundabout 2 0.0435 0.4258 0.4011
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Echinococcus multilocularis Fibronectin, type III 0.0277 0.0771 0.0373
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0277 0.0771 0.0919
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0277 0.0771 0.5
Echinococcus multilocularis titin 0.035 0.2387 0.2059
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0261 0.0413 0.0493
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0435 0.4258 0.6305
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Echinococcus multilocularis usherin 0.0277 0.0771 0.0373
Onchocerca volvulus 0.035 0.2387 1
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0277 0.0771 0.5
Loa Loa (eye worm) hypothetical protein 0.035 0.2387 0.3236
Brugia malayi Fibronectin type III domain containing protein 0.0538 0.6512 1
Schistosoma mansoni cell adhesion molecule 0.0435 0.4258 0.5079
Loa Loa (eye worm) projectin 0.035 0.2387 0.3236
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0277 0.0771 0.0373
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0346 0.2285 0.1952
Schistosoma mansoni titin 0.035 0.2387 0.2847
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0277 0.0771 0.0373
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0362 0.2642 0.2325
Loa Loa (eye worm) UNCoordinated family member 0.0277 0.0771 0.0586
Leishmania major hypothetical protein, conserved 0.0277 0.0771 0.5
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0277 0.0771 0.0586
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0362 0.2642 0.3655
Echinococcus granulosus roundabout 2 0.0435 0.4258 0.4011
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0277 0.0771 0.0919
Echinococcus multilocularis Netrin receptor DCC 0.0277 0.0771 0.0373
Echinococcus multilocularis neuroglian 0.0334 0.2029 0.1686
Echinococcus granulosus EG95 0.0277 0.0771 0.0373
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0435 0.4258 0.5079
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0361 0.2611 0.2293
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.2387 0.2815
Brugia malayi Immunoglobulin I-set domain containing protein 0.0435 0.4258 0.6075
Schistosoma mansoni hemicentin 0.035 0.2387 0.2847
Schistosoma mansoni titin 0.035 0.2387 0.2847
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0435 0.4258 0.4011
Schistosoma mansoni vesicular amine transporter 0.0261 0.0413 0.0493
Loa Loa (eye worm) lethal protein 805 0.0277 0.0771 0.0586
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.2387 0.2815
Loa Loa (eye worm) hypothetical protein 0.0277 0.0771 0.0586
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.2387 0.2815
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0435 0.4258 0.4011
Schistosoma mansoni tripartite motif protein trim9 0.0277 0.0771 0.0919

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.66 uM Inhibitory activity of the compound against yeast aldehyde dehydrogenase(AIDH) ChEMBL. 9667978
IC50 (binding) = 1.66 uM Inhibitory activity of the compound against yeast aldehyde dehydrogenase(AIDH) ChEMBL. 9667978

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.