Detailed information for compound 1646359

Basic information

Technical information
  • TDR Targets ID: 1646359
  • Name: 3-(naphthalen-2-ylmethylideneamino)-1-(4-nitr ophenyl)urea
  • MW: 334.329 | Formula: C18H14N4O3
  • H donors: 2 H acceptors: 3 LogP: 3.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)[N+](=O)[O-])N/N=C\c1ccc2c(c1)cccc2
  • InChi: 1S/C18H14N4O3/c23-18(20-16-7-9-17(10-8-16)22(24)25)21-19-12-13-5-6-14-3-1-2-4-15(14)11-13/h1-12H,(H2,20,21,23)/b19-12-
  • InChiKey: GIMIOKCHAJQOGI-UNOMPAQXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-naphthylmethyleneamino)-1-(4-nitrophenyl)urea
  • NSC691665

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine protein kinase ATM 0.0106 0.027 0.0333
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Giardia lamblia Heat shock protein HSP 90-alpha 0.046 0.1341 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0066 0.0491
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0013 0.0094
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0066 0.013
Schistosoma mansoni plexin 0.0023 0.002 0.0045
Trichomonas vaginalis heat shock protein, putative 0.0366 0.1058 0.779
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0188 0.0518 0.3725
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0036 0.0059 0.0073
Trichomonas vaginalis endoplasmin, putative 0.0282 0.0803 0.5804
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0366 0.1058 0.3566
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0212 0.1581
Mycobacterium ulcerans putative regultory protein 0.0094 0.0233 0.1687
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0102
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0036 0.0059 0.0059
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0366 0.1058 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0013 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0075 0.0169
Loa Loa (eye worm) hypothetical protein 0.0094 0.0233 0.1739
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0075 0.0557
Entamoeba histolytica protein kinase rad3, putative 0.0106 0.027 0.1829
Trypanosoma cruzi DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Echinococcus multilocularis protein patched 0.0087 0.0212 0.0212
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Schistosoma mansoni fkbp-rapamycin associated protein 0.0106 0.027 0.061
Toxoplasma gondii DNA topoisomerase 2, putative 0.0094 0.0233 0.1681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma cruzi heat shock protein 90, putative 0.046 0.1341 0.4728
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0013 0.0094
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Brugia malayi mbt repeat family protein 0.0048 0.0094 0.0699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trichomonas vaginalis heat shock protein, putative 0.0188 0.052 0.3594
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0106
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0036 0.0059 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0094 0.0233 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Entamoeba histolytica heat shock protein 90, putative 0.046 0.1341 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0106
Giardia lamblia Hypothetical protein 0.0036 0.0059 0.0374
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0044 0.0044
Echinococcus multilocularis pyruvate kinase 0.0038 0.0066 0.0066
Echinococcus multilocularis pyruvate kinase 0.002 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.1761
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0441
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0233 0.1681
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0013 0.0015
Trypanosoma cruzi DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Leishmania major hypothetical protein, unknown function 0.0036 0.0059 0.0102
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.003 0.0153
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0123 0.0918
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0013 0.0179
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0013 0.0179
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0107 0.0419
Brugia malayi hypothetical protein 0.0248 0.0699 0.5213
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0066 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus granulosus plexin a4 0.0047 0.0092 0.0113
Brugia malayi Endoplasmin precursor 0.046 0.1341 1
Brugia malayi hypothetical protein 0.0017 0.0001 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0013 0.0013
Echinococcus multilocularis geminin 0.0177 0.0487 0.0487
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0066 0.0066
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0188 0.0518 0.0518
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0212 0.0262
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0212 0.0212
Loa Loa (eye worm) phosphatidylinositol 3 0.0188 0.0518 0.3864
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0013 0.0028
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0082 0.0198 0.0244
Loa Loa (eye worm) MBCTL1 0.0054 0.0114 0.0847
Echinococcus multilocularis Niemann Pick C1 protein 0.0289 0.0823 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Plasmodium vivax DNA topoisomerase II, putative 0.0094 0.0233 0.1681
Brugia malayi nuclear hormone receptor 0.0021 0.0013 0.0094
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0188 0.0518 0.1695
Echinococcus multilocularis protein dispatched 1 0.0099 0.0249 0.0249
Mycobacterium ulcerans heat shock protein 90 0.0366 0.1058 1
Toxoplasma gondii heat shock protein HSP90 0.046 0.1341 1
Echinococcus granulosus muscleblind protein 0.032 0.092 0.1134
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0307 0.1933
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0094 0.0233 0.0233
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0188 0.0518 0.117
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0188 0.0518 0.0639
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0188 0.0518 0.3864
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Brugia malayi Pre-SET motif family protein 0.0031 0.0044 0.0331
Giardia lamblia Grp94/Hsp90 0.0366 0.1058 0.7872
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0005
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0094 0.0233 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0013 0.0094
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0066 0.0275
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0094 0.0699
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0013 0.0094
Echinococcus multilocularis microtubule associated protein 2 0.1481 0.4431 0.4431
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0107 0.0419
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0013 0.0013
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.0233 0.1681
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0094 0.0233 0.1687
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0106
Echinococcus multilocularis pyruvate kinase 0.002 0.0009 0.0009
Schistosoma mansoni heat shock protein 0.046 0.1341 0.3027
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0059 0.0374
Brugia malayi Probable DNA topoisomerase II 0.0094 0.0233 0.1739
Trichomonas vaginalis heat shock protein, putative 0.046 0.1341 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.1761
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0036 0.0059 0.0106
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0036 0.0059 0.0134
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0013 0.0028
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Plasmodium vivax heat shock protein 90, putative 0.0188 0.052 0.3834
Loa Loa (eye worm) heat shock protein 90 0.046 0.1341 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.003 0.0153
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0441
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0221
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0013 0.0015
Trypanosoma cruzi Heat shock protein 83, putative 0.046 0.1341 0.4728
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Trichomonas vaginalis heat shock protein, putative 0.0366 0.1058 0.779
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0013 0.0015
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Schistosoma mansoni pyruvate kinase 0.0038 0.0066 0.0149
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0188 0.0518 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0036 0.0059 0.0073
Trypanosoma cruzi heat shock protein 85, putative 0.046 0.1341 0.4728
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0107 0.0269
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0013 0.0094
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0106 0.027 0.0333
Mycobacterium leprae Probable two-component sensor kinase 0.0094 0.0233 0.1742
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0068 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0013 0.0094
Trypanosoma cruzi heat shock protein 85, putative 0.046 0.1341 0.4728
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0225
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0107 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Loa Loa (eye worm) hypothetical protein 0.0118 0.0307 0.2289
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0094 0.0233 0.1739
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0044 0.01
Chlamydia trachomatis DNA gyrase subunit B 0.0094 0.0233 1
Toxoplasma gondii heat shock protein 75, putative 0.0188 0.052 0.3834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Giardia lamblia Phosphatidylinositol 4-kinase 0.0036 0.0059 0.0374
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0094 0.0233 0.1687
Echinococcus granulosus Niemann Pick C1 protein 0.0289 0.0823 0.1015
Echinococcus multilocularis muscleblind protein 0.032 0.092 0.092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0041 0.005
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0114 0.014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0509
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0066 0.094
Schistosoma mansoni hypothetical protein 0.0289 0.0825 0.1861
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0094 0.0233 0.1739
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.027 0.2016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0801
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0075 0.0075
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0094 0.0233 0.1742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0188 0.0518 0.1761
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0107 0.0585
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0188 0.0518 0.1695
Brugia malayi Hsp90 protein 0.0188 0.052 0.3877
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0036 0.0059 0.0134
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Onchocerca volvulus 0.0031 0.0044 0.0634
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0013 0.0028
Echinococcus granulosus heat shock protein 0.046 0.1341 0.1654
Echinococcus granulosus heat shock protein 90 0.046 0.1341 0.1654
Loa Loa (eye worm) TOPoisomerase family member 0.0094 0.0233 0.1739
Plasmodium vivax SET domain protein, putative 0.0031 0.0044 0.0263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0066 0.0491
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0107 0.0269
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0036 0.0059 0.0106
Giardia lamblia GTOR 0.0188 0.0518 0.3821
Trichomonas vaginalis heat shock protein, putative 0.0282 0.0803 0.5804
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma cruzi heat shock protein, putative 0.0188 0.052 0.1767
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0087 0.0212 0.1581
Schistosoma mansoni patched 1 0.0087 0.0212 0.0479
Onchocerca volvulus 0.005 0.0103 0.1466
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Trypanosoma cruzi target of rapamycin kinase 3 0.0188 0.0518 0.1761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni hypothetical protein 0.0082 0.0198 0.0446
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0066 0.0491
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0094 0.0233 0.1357
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0094 0.0233 0.1742
Plasmodium vivax hypothetical protein 0.0036 0.0059 0.0374
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0094 0.0233 0.1742
Plasmodium falciparum DNA gyrase subunit B 0.0094 0.0233 0.1681
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0094 0.0233 0.1687
Loa Loa (eye worm) hypothetical protein 0.004 0.007 0.0521
Loa Loa (eye worm) hypothetical protein 0.007 0.0161 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0094 0.0233 0.1742
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0013 0.0015
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.2696 0.8111 1
Trypanosoma brucei DNA topoisomerase ii 0.0094 0.0233 0.1552
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0031 0.0229
Schistosoma mansoni hypothetical protein 0.0041 0.0075 0.0169
Treponema pallidum heat shock protein 90 0.0366 0.1058 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0374
Toxoplasma gondii Hsp90 domain-containing protein 0.0188 0.052 0.3834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0013 0.0028
Brugia malayi Pre-SET motif family protein 0.0218 0.0609 0.4543
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0094 0.0233 0.1742
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0013 0.0013
Brugia malayi Muscleblind-like protein 0.032 0.092 0.6858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0118 0.0307 0.2115
Leishmania major pyruvate kinase 0.0038 0.0066 0.0125
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0517 0.0517
Trichomonas vaginalis heat shock protein, putative 0.0366 0.1058 0.779
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0013 0.0094
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0036 0.0059 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0161 0.0795
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0036 0.0059 0.0134
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0013 0.0013
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0094 0.0233 0.3329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus multilocularis 0.0036 0.0059 0.0059
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.0561 0.4046
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0106 0.027 0.027
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0068 0.0437
Echinococcus multilocularis plexin a4 0.0047 0.0092 0.0092
Plasmodium falciparum endoplasmin, putative 0.0282 0.0803 0.5961
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0107 0.0585
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0114 0.0114
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0013 0.0028
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0066 0.094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0013 0.0028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0005 0.0035
Brugia malayi CHE-14 protein 0.0087 0.0212 0.1581
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Brugia malayi hypothetical protein 0.0041 0.0075 0.0559
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0036 0.0059 0.0134
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0068 0.0084
Echinococcus granulosus geminin 0.0177 0.0487 0.06
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0188 0.052 0.3733
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0013 0.0094
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0013 0.0094
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0075 0.0092
Schistosoma mansoni heat shock protein 0.046 0.1341 0.3027
Plasmodium falciparum heat shock protein 90, putative 0.0188 0.052 0.3834
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Leishmania major hypothetical protein, conserved 0.0979 0.2913 1
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0075 0.0169
Schistosoma mansoni hypothetical protein 0.0039 0.0068 0.0154
Schistosoma mansoni coup transcription factor 0.0021 0.0013 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0107 0.0483
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0066 0.0491
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0013 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0094 0.0233 0.1742
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0701 0.5002
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0013 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0161 0.0795
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.003 0.0153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0035
Schistosoma mansoni plexin 0.004 0.007 0.0158
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0094 0.0233 0.1742
Trypanosoma cruzi heat shock protein 90, putative 0.0366 0.1058 0.3706
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0094 0.0116
Onchocerca volvulus 0.0036 0.0059 0.0845
Brugia malayi plexin A 0.0047 0.0092 0.0685
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0013 0.0094
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0248 0.0699 0.5213
Echinococcus multilocularis GPCR, family 2 0.0018 0.0005 0.0005
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0198 0.108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0013 0.0094
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0036 0.0059 0.0106
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0517 0.0637
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0094 0.0233 0.0288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0013 0.0028
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0036 0.0059 0.0134
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0094 0.0233 0.0734
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0366 0.1058 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0044 0.01
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0107 0.0483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0013 0.0094
Mycobacterium leprae Probable two component sensor kinase MprB 0.0094 0.0233 0.1742
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.003 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus multilocularis pyruvate kinase 0.002 0.0009 0.0009
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0094 0.0233 0.3329
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0188 0.0518 0.3721
Loa Loa (eye worm) plexin A 0.0047 0.0092 0.0685
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0699 0.0862
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.0561 0.4182
Toxoplasma gondii heat shock protein 90, putative 0.046 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.027 0.2016
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0036 0.0059 0.0217
Brugia malayi heat shock protein 90 0.046 0.1341 1
Plasmodium vivax endoplasmin, putative 0.046 0.1341 1
Brugia malayi kinase, mitochondrial precursor 0.0094 0.0233 0.1739
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0066 0.094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Trichomonas vaginalis receptor histidine kinase, putative 0.0094 0.0233 0.1357
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0188 0.0518 0.3725
Echinococcus granulosus expressed conserved protein 0.019 0.0524 0.0646
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Echinococcus granulosus GPCR family 2 0.0018 0.0005 0.0006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0107 0.0419
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0006
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0094 0.0094
Trypanosoma cruzi heat shock protein 90, putative 0.0271 0.0771 0.2673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0013 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0374
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0106 0.027 0.0868
Echinococcus granulosus pyruvate kinase 0.0038 0.0066 0.0081
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0094 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0107 0.0801
Entamoeba histolytica DNA topoisomerase II, putative 0.0094 0.0233 0.1545
Mycobacterium ulcerans hypothetical protein 0.0052 0.0107 0.0419
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0114 0.0256
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0036 0.0059 0.0225
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0044 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.0307 0.1933
Leishmania major pyruvate kinase 0.0038 0.0066 0.0125
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0013 0.0028
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0107 0.0801
Giardia lamblia Pms1-like protein 0.0094 0.0233 0.1681
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0013 0.0094
Trypanosoma brucei heat shock protein 84, putative 0.0188 0.052 0.3738
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0066 0.0424
Echinococcus multilocularis expressed conserved protein 0.019 0.0524 0.0524
Leishmania major phosphatidylinositol kinase, putative 0.0036 0.0059 0.0102
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0036 0.0059 0.0059
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0114 0.014
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0059 0.0374
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0118 0.0307 0.2235
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0094 0.0233 0.1742
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0225
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0066 0.0491
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0123 0.0918
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0094 0.0233 0.0288
Plasmodium falciparum DNA topoisomerase 2 0.0094 0.0233 0.1681
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0013 0.0013
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0036 0.0059 0.0134
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.0233 0.1681
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0013 0.0013
Plasmodium vivax DNA gyrase subunit B, putative 0.0094 0.0233 0.1681
Echinococcus multilocularis pyruvate kinase 0.003 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0013 0.0094
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0059 0.0374
Leishmania major heat shock protein, putative 0.0188 0.052 0.17
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Echinococcus granulosus endoplasmin 0.0366 0.1058 0.1304
Onchocerca volvulus 0.004 0.007 0.0998
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0107 0.0483
Schistosoma mansoni pyruvate dehydrogenase 0.0094 0.0233 0.0526
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0106 0.027 0.1836
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Schistosoma mansoni hypothetical protein 0.0177 0.0487 0.1099
Leishmania major DNA topoisomerase ii 0.0094 0.0233 0.0706
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.032 0.092 0.6858
Schistosoma mansoni endoplasmin 0.046 0.1341 0.3027
Brugia malayi hypothetical protein 0.0026 0.003 0.0221
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Loa Loa (eye worm) hypothetical protein 0.0202 0.0561 0.4182
Brugia malayi nuclear receptor NHR-88 0.0021 0.0013 0.0094
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0066 0.0424
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0094 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.3725
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0094 0.0233 0.1552
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0217
Plasmodium vivax heat shock protein 86, putative 0.046 0.1341 1
Schistosoma mansoni microtubule-associated protein tau 0.1481 0.4431 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0066 0.0066
Leishmania major phosphatidylinositol kinase related protein, putative 0.0036 0.0059 0.0102
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0188 0.0518 0.1695
Leishmania major developmentally regulated phosphoprotein-like protein 0.0094 0.0233 0.0706
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0188 0.052 0.052
Trypanosoma cruzi heat shock protein 85, putative 0.046 0.1341 0.4728
Brugia malayi Plexin repeat family protein 0.004 0.007 0.0521
Onchocerca volvulus 0.0036 0.0059 0.0845
Toxoplasma gondii target of rapamycin (TOR), putative 0.0188 0.0518 0.3821
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0013 0.0028
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0107 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0013 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Loa Loa (eye worm) phosphatidylinositol kinase 0.0036 0.0059 0.0441
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0094 0.0233 0.1552
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0068 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0013 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0943 0.2804 1
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0066 0.0275
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0188 0.0518 0.3864
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.007 0.0161 0.0474
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0013 0.0028
Schistosoma mansoni pyruvate kinase 0.0038 0.0066 0.0149
Trichomonas vaginalis sensor histidine kinase, putative 0.0094 0.0233 0.1357
Schistosoma mansoni heat shock protein 0.0188 0.052 0.1173
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0036 0.0059 0.0225
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.027 0.2016
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0094 0.0233 0.1742
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0013 0.0015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0075 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0036 0.0059 0.0073
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0094 0.0233 0.1739
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0075 0.0092
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0094 0.0233 0.1687
Schistosoma mansoni DNA topoisomerase II 0.0094 0.0233 0.0526
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0013 0.0013
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0188 0.0518 0.3721
Echinococcus granulosus pyruvate kinase 0.002 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0052 0.0107 0.0801
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0036 0.0059 0.0374
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0013 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Schistosoma mansoni pyruvate kinase 0.002 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0094 0.0233 0.1739
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0036 0.0059 0.0374
Leishmania major hypothetical protein, conserved 0.0094 0.0233 0.0706
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2696 0.8111 0.8111
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0106 0.027 0.061
Echinococcus multilocularis pyruvate kinase 0.0038 0.0066 0.0066
Mycobacterium tuberculosis Possible two component sensor kinase 0.0094 0.0233 0.1742
Echinococcus granulosus pyruvate kinase 0.002 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.005 0.0103 0.0232
Brugia malayi steroid hormone receptor 0.0021 0.0013 0.0094
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0188 0.052 0.0641
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0123 0.0918
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0094 0.0233 0.1687
Leishmania major mitochondrial DNA topoisomerase II 0.0094 0.0233 0.0706
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0066 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0106 0.0271 0.2021
Loa Loa (eye worm) phosphatidylinositol 3 0.0188 0.0518 0.3864
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0044 0.01
Brugia malayi ecdysteroid receptor 0.0021 0.0013 0.0094
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0188 0.0518 0.0518
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0094 0.0233 0.0233
Mycobacterium ulcerans two component sensor kinase MprB 0.0094 0.0233 0.1687
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0177 0.0487 0.1099
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0013 0.0015
Entamoeba histolytica hypothetical protein 0.0036 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0068 0.0509
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0036 0.0059 0.0059
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Echinococcus granulosus pyruvate kinase 0.0038 0.0066 0.0081
Giardia lamblia Pyruvate kinase 0.0038 0.0066 0.0424
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0094 0.0233 0.0734
Plasmodium falciparum pyruvate kinase 0.0038 0.0066 0.0424
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Brugia malayi mbt repeat family protein 0.0048 0.0094 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0212 0.1192
Toxoplasma gondii FATC domain-containing protein 0.0106 0.027 0.196
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0107 0.0801
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0107 0.0419
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0075 0.0169
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0212 0.0262
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.0233 0.1681
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0036 0.0059 0.0106
Onchocerca volvulus 0.0248 0.0701 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0107 0.0419
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0366 0.1058 0.1304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Loa Loa (eye worm) endoplasmin 0.046 0.1341 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0188 0.0518 0.117
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0036 0.0059 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0044 0.01
Loa Loa (eye worm) hypothetical protein 0.0082 0.0198 0.1474
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0005
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0036 0.0059 0.0441
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0068 0.0437
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0057 0.0123 0.0918
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0094 0.1338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trypanosoma cruzi heat shock protein 85, putative 0.0366 0.1058 0.3706
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0013 0.0179
Echinococcus multilocularis heat shock protein 0.046 0.1341 0.1341
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0609 0.4543
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0005 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0066 0.0491
Loa Loa (eye worm) heat shock protein 75 0.0188 0.052 0.3877
Mycobacterium tuberculosis Conserved protein 0.0094 0.0233 0.1742
Trypanosoma brucei heat shock protein, putative 0.046 0.1341 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0114 0.0114
Onchocerca volvulus 0.0052 0.0107 0.1533
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0075 0.0075
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0036 0.0059 0.0374
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0094 0.0233 0.1742
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0188 0.0518 0.1761
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Schistosoma mansoni hypothetical protein 0.0036 0.0059 0.0134
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Echinococcus granulosus pyruvate kinase 0.002 0.0009 0.0012
Trypanosoma brucei developmentally regulated phosphoprotein 0.0094 0.0233 0.1552
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0066 0.0052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0044 0.0263
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0013 0.0094
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0036 0.0059 0.0106
Brugia malayi FAT domain containing protein 0.0082 0.0198 0.1474
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0106 0.027 0.1829
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0106 0.027 0.0868
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0107 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0013 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0094
Trichomonas vaginalis receptor histidine kinase, putative 0.0094 0.0233 0.1357
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0094 0.0233 0.1742
Entamoeba histolytica hypothetical protein 0.0041 0.0075 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0094 0.0212
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.027 0.1648
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.057 0.1287
Entamoeba histolytica heat shock protein 90, putative 0.046 0.1341 1
Trypanosoma brucei heat shock protein 90, putative 0.046 0.1341 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0366 0.1058 1
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Onchocerca volvulus 0.0019 0.0008 0.0119
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0188 0.052 0.7423
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0188 0.0518 0.1695
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0036 0.0059 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0107 0.0419
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0094 0.0233 0.1357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0013 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0036 0.0059 0.0134
Echinococcus multilocularis heat shock protein 90 0.046 0.1341 0.1341
Echinococcus multilocularis Zinc finger, PHD finger 0.0036 0.0059 0.0059
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0036 0.0059 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0075 0.0557
Plasmodium falciparum heat shock protein 90, putative 0.0188 0.052 0.3834
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0094 0.0233 0.1687
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0107 0.0419
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0094 0.0233 0.1742
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0094 0.0233 0.1552
Echinococcus multilocularis endoplasmin 0.0366 0.1058 0.1058
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0094 0.0212
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0082 0.0198 0.0198
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0005 0.0035
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0188 0.0518 0.3725
Onchocerca volvulus 0.0021 0.0013 0.0179
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0374
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0094 0.0233 0.0734
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.0561 0.0561
Giardia lamblia Heat shock protein HSP 90-alpha 0.0366 0.1058 0.7872
Mycobacterium ulcerans DNA gyrase subunit B 0.0094 0.0233 0.1687
Trichomonas vaginalis DNA topoisomerase II, putative 0.0094 0.0233 0.1357
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0036 0.0059 0.0106
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0094 0.0233 0.3329
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0094 0.0094
Mycobacterium tuberculosis Probable two component sensor kinase 0.0094 0.0233 0.1742
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0188 0.0518 0.3725
Loa Loa (eye worm) hypothetical protein 0.032 0.092 0.6858
Trypanosoma brucei heat shock protein 90, putative 0.046 0.1341 1
Echinococcus granulosus heat shock protein 90 0.0366 0.1058 0.1304
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.0045
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0103 0.0765
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0147
Echinococcus granulosus microtubule associated protein 2 0.1481 0.4431 0.5464
Plasmodium falciparum heat shock protein 90 0.046 0.1341 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0075 0.0092
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0094 0.0233 0.1357
Echinococcus multilocularis heat shock protein 90 0.0366 0.1058 0.1058
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0013 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0059 0.0441
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0036 0.0059 0.0441
Schistosoma mansoni hypothetical protein 0.0084 0.0203 0.0457
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0699
Echinococcus multilocularis serine protein kinase ATM 0.0106 0.027 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0059 0.0441
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0094 0.0233 0.1357
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0094 0.0233 0.1681
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0094 0.0233 0.1742
Schistosoma mansoni survival motor neuron protein 0.005 0.0103 0.0232
Loa Loa (eye worm) hypothetical protein 0.0054 0.0114 0.0847
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0699 0.0699
Onchocerca volvulus 0.0048 0.0094 0.1338
Trypanosoma brucei Heat shock protein 83, putative 0.046 0.1341 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0094 0.0233 0.1357
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0036 0.0059 0.0374
Leishmania major phosphatidylinositol 4-kinase, putative 0.0036 0.0059 0.0102
Leishmania major phosphatidylinositol 3-kinase, putative 0.0188 0.0518 0.1695
Schistosoma mansoni endoplasmin 0.046 0.1341 0.3027
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0094 0.0233 1
Plasmodium vivax heat shock protein, putative 0.0188 0.052 0.3834
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0036 0.0059 0.0217
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0094 0.0233 0.1687
Entamoeba histolytica hypothetical protein 0.0106 0.027 0.1829
Chlamydia trachomatis DNA gyrase subunit B 0.0094 0.0233 1
Leishmania major heat shock protein 83-1 0.046 0.1341 0.4548
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0114 0.0847
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.0561 0.0692
Echinococcus multilocularis muscleblind protein 1 0.032 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.0039 0.0068 0.0504
Mycobacterium ulcerans two component regulator - sensor kinase 0.0094 0.0233 0.1687
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0518 0.3581

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.757 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.709 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.653 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.644 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.635 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.629 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.625 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.617 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.609 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.558 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.237 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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