Detailed information for compound 1655704

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.283 | Formula: C23H17IO4
  • H donors: 1 H acceptors: 2 LogP: 5.99 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1oc2c(c1C(=O)O)cc(cc2)OCc1cccc(c1)I
  • InChi: 1S/C23H17IO4/c1-14-5-7-16(8-6-14)22-21(23(25)26)19-12-18(9-10-20(19)28-22)27-13-15-3-2-4-17(24)11-15/h2-12H,13H2,1H3,(H,25,26)
  • InChiKey: SGJBHFRLKMEYKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens anoctamin 1, calcium activated chloride channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127202 All targets in OG5_127202
Onchocerca volvulus Get druggable targets OG5_127202 All targets in OG5_127202
Schistosoma japonicum Transmembrane protein 16C, putative Get druggable targets OG5_127202 All targets in OG5_127202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127202 All targets in OG5_127202
Schistosoma japonicum Transmembrane protein 16G, putative Get druggable targets OG5_127202 All targets in OG5_127202
Leishmania braziliensis hypothetical protein, unknown function Get druggable targets OG5_127202 All targets in OG5_127202
Brugia malayi Transmembrane protein 16C Get druggable targets OG5_127202 All targets in OG5_127202
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Echinococcus multilocularis protein of unknown function DUF590 0.0037 0.0087 0.0087
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0052 0.0162 0.0736
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.05 0.1866
Schistosoma mansoni glutamate synthase 0.0052 0.0162 0.0162
Schistosoma mansoni microtubule-associated protein tau 0.2047 1 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0004 0.001
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0052 0.0162 0.0603
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0424 0.1995 0.2733
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0001 0.0004
Giardia lamblia Fructose-bisphosphate aldolase 0.0867 0.4181 1
Onchocerca volvulus 0.003 0.0052 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0269 0.1003
Brugia malayi Transmembrane protein 16C 0.0061 0.0206 0.0509
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0195 0.0867 0.3237
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0052 0.0162 0.0134
Mycobacterium ulcerans hypothetical protein 0.0162 0.0703 0.3048
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0052 0.0162 0.0603
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0052 0.0162 0.0162
Brugia malayi phosphofructokinase 0.0107 0.0434 0.1073
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0005 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0137 0.051
Mycobacterium ulcerans DNA polymerase IV 0.0177 0.078 0.3462
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0049 0.0098
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0478 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0248 0.053
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0386 0.0386
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0248 0.0927
Echinococcus granulosus axis inhibition protein axin 0.002 0.0004 0.0004
Mycobacterium tuberculosis Probable reductase 0.1283 0.623 0.8962
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0434 0.0437
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0037 0.0093
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0867 0.4181 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0052 0.0162 0.0377
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0052 0.0162 0.0603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0135 0.0135
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0143 0.0612 0.1514
Trypanosoma brucei polo-like protein kinase 0.0097 0.0386 0.1441
Brugia malayi jmjC domain containing protein 0.0192 0.0855 0.2113
Brugia malayi hypothetical protein 0.0025 0.0032 0.0078
Toxoplasma gondii peptidylprolyl isomerase 0.013 0.0545 0.2036
Brugia malayi ImpB/MucB/SamB family protein 0.0202 0.0904 0.2235
Toxoplasma gondii thioredoxin reductase 0.0562 0.2679 1
Brugia malayi MH2 domain containing protein 0.0239 0.1084 0.268
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0434 0.162
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0309 0.0309
Schistosoma mansoni jumonji domain containing protein 0.0153 0.066 0.066
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0166 0.0411
Trypanosoma cruzi trypanothione reductase, putative 0.0195 0.0867 0.3237
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0195 0.0867 0.0867
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1283 0.623 0.8962
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0137 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0561 0.1208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0434 0.16
Giardia lamblia Kinase, PLK 0.0097 0.0386 0.0815
Plasmodium falciparum phd finger protein, putative 0.0059 0.0196 0.0732
Trypanosoma brucei trypanothione reductase 0.0562 0.2679 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.05 0.05
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Loa Loa (eye worm) hypothetical protein 0.0059 0.0196 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0004 0.001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0162 0.0342
Trypanosoma cruzi trypanothione reductase, putative 0.0562 0.2679 1
Plasmodium falciparum glutathione reductase 0.0195 0.0867 0.3237
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0052 0.0162 0.0603
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0177 0.078 0.1683
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0264 0.0264
Schistosoma mansoni transcription factor btf3 0.0069 0.0248 0.0248
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0195 0.0867 0.3237
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0162 0.0603
Echinococcus granulosus protein of unknown function DUF590 0.0037 0.0087 0.0087
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0052 0.0162 0.0603
Echinococcus granulosus expressed protein 0.0384 0.1801 0.1801
Echinococcus multilocularis microtubule associated protein 2 0.2047 1 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0052 0.0162 0.0036
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0052 0.0162 0.0036
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0196 0.0485
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0004 0.0004
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0434 0.0437
Mycobacterium ulcerans ferredoxin reductase 0.0052 0.0162 0.0134
Trichomonas vaginalis rotamase, putative 0.013 0.0545 0.1174
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0829
Echinococcus granulosus Solute carrier family 22 5 0.1019 0.4929 0.4929
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Echinococcus multilocularis transcription factor btf3 0.0069 0.0248 0.0248
Echinococcus multilocularis protein of unknown function DUF590 0.0037 0.0087 0.0087
Onchocerca volvulus 0.0955 0.4616 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0032 0.0118
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0137 0.0213
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0562 0.2679 0.3738
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0257 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0004 0.0004
Trichomonas vaginalis mercuric reductase, putative 0.0195 0.0867 0.1872
Brugia malayi PHD-finger family protein 0.0059 0.0196 0.0485
Onchocerca volvulus 0.0052 0.0162 0.0271
Trichomonas vaginalis apoptosis inducing factor, putative 0.0052 0.0162 0.0342
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0052 0.0162 0.0603
Leishmania major hypothetical protein, conserved 0.0025 0.0032 0.0118
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0004 0.0004
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0005 0.0005
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0001 0.0004
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0434 0.0434
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0032 0.0118
Trypanosoma brucei unspecified product 0.0104 0.0418 0.156
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0004 0.0004
Giardia lamblia PHD finger protein 15 0.0059 0.0196 0.0356
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.0162 0.0603
Brugia malayi hypothetical protein 0.002 0.0004 0.001
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0052 0.0162 0.0603
Mycobacterium ulcerans dehydrogenase 0.0052 0.0162 0.0134
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0052 0.0162 0.0342
Schistosoma mansoni hypothetical protein 0.0061 0.0206 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0248 0.053
Plasmodium vivax ferrodoxin reductase, putative 0.0052 0.0162 0.0603
Trichomonas vaginalis glutathione reductase, putative 0.0195 0.0867 0.1872
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0195 0.0867 0.3237
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0195 0.0867 0.3237
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0434 0.1073
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0049 0.0108
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0162 0.0603
Echinococcus granulosus thioredoxin glutathione reductase 0.0565 0.2694 0.2694
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Brugia malayi Thioredoxin reductase 0.0562 0.2679 0.6625
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0052 0.0162 0.0342
Leishmania major hypothetical protein, conserved 0.0052 0.0162 0.0603
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0162 0.0603
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0032 0.0118
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1084 0.268
Trypanosoma brucei NADH dehydrogenase 0.0052 0.0162 0.0603
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Trypanosoma brucei DNA damage repair protein, putative 0.0047 0.0137 0.051
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1426 0.6936 1
Trypanosoma brucei unspecified product 0.0104 0.0418 0.156
Echinococcus granulosus protein of unknown function DUF590 0.0037 0.0087 0.0087
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0004 0.001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1426 0.6936 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0052 0.0162 0.04
Plasmodium vivax glutathione reductase, putative 0.0562 0.2679 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0047 0.0137 0.051
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Onchocerca volvulus 0.005 0.0152 0.025
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1419 0.5296
Treponema pallidum thioredoxin reductase (trxB) 0.0052 0.0162 0.0272
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0052 0.0162 0.0342
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2912
Schistosoma mansoni hypothetical protein 0.0059 0.0196 0.0196
Giardia lamblia NADH oxidase lateral transfer candidate 0.0195 0.0867 0.198
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0052 0.0162 0.0603
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.1419 0.5296
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0162 0.0342
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0049 0.0183
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0004 0.0004
Treponema pallidum fructose-bisphosphate aldolase 0.0867 0.4181 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.013 0.0545 0.1296
Leishmania major DNA polymerase eta, putative 0.0202 0.0904 0.3374
Trypanosoma brucei DNA damage repair protein, putative 0.0047 0.0137 0.051
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0195 0.0867 0.3237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Echinococcus multilocularis peregrin 0.0059 0.0196 0.0196
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0052 0.0162 0.0272
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0052 0.0162 0.0134
Brugia malayi hypothetical protein 0.002 0.0004 0.001
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0137 0.0512
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0078
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0053 0.0169 0.0633
Trichomonas vaginalis set domain proteins, putative 0.0955 0.4615 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0037 0.0037
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0434 0.0434
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Echinococcus granulosus peregrin 0.0059 0.0196 0.0196
Onchocerca volvulus Alhambra homolog 0.0059 0.0196 0.0346
Schistosoma mansoni DNA polymerase eta 0.0202 0.0904 0.0904
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0867 0.4181 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0004 0.0004
Leishmania major DNA polymerase kappa, putative 0.0157 0.0681 0.2541
Brugia malayi intermediate filament protein 0.0027 0.0037 0.0093
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0052 0.0162 0.0603
Echinococcus multilocularis expressed protein 0.0384 0.1801 0.1801
Schistosoma mansoni glutamate synthase 0.0052 0.0162 0.0162
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0257 0.0257
Brugia malayi Pre-SET motif family protein 0.0839 0.4043 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0119 0.0445
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0137 0.0512
Brugia malayi PXA domain containing protein 0.002 0.0004 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0703 0.0832
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0099 0.0392 0.1465
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0052 0.0162 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0933
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0049 0.0183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.015 0.0648 0.0648
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0052 0.0162 0.0603
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0434 0.162
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0135 0.0333
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0052 0.0162 0.0162
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0195 0.0867 1
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0248 0.053
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0052 0.0162 0.0162
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1283 0.623 0.8962
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0052 0.0162 0.0162
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0195 0.0867 0.3237
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0195 0.0867 0.1074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0185 0.0259
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0195 0.0867 0.3931
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Brugia malayi glutathione reductase 0.0562 0.2679 0.6625
Trypanosoma brucei DNA polymerase IV, putative 0.0177 0.078 0.2912
Entamoeba histolytica thioredoxin reductase, putative 0.0052 0.0162 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0451 0.1682
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0052 0.0162 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0269 0.1003
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0185 0.0259
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0157 0.0681 0.2541
Treponema pallidum NADH oxidase 0.0195 0.0867 0.198
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0137 0.0512
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.013 0.0545 0.2036
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.015 0.0648 0.0648
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.05 0.05
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.05 0.05
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0185 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0829
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0386 0.0761
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0005 0.0013
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.0855 0.0855
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0052 0.0162 0.0377
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0052 0.0162 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0195 0.0867 0.0867
Trichomonas vaginalis rotamase, putative 0.0133 0.0561 0.1208
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0248 0.0927
Brugia malayi AF-10 protein 0.0019 0.0001 0.0003
Plasmodium falciparum thioredoxin reductase 0.0195 0.0867 0.3237
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0386 0.0915
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0052 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni sulfide quinone reductase 0.0052 0.0162 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0137 0.051
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1426 0.6936 1
Toxoplasma gondii NADPH-glutathione reductase 0.0195 0.0867 0.3237
Leishmania major DNA polymerase kappa, putative 0.0047 0.0137 0.051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0257 0.0257
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0032 0.0118
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0119 0.0445
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0032 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Schistosoma mansoni intermediate filament proteins 0.0027 0.0037 0.0037
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0166 0.0726 0.0726
Mycobacterium tuberculosis Probable dehydrogenase 0.1283 0.623 0.8962
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0004 0.0004
Echinococcus multilocularis expressed protein 0.0133 0.0561 0.0561
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0137 0.0512
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0004 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1084 0.268
Echinococcus granulosus L aminoadipate semialdehyde 0.0166 0.0726 0.0726
Echinococcus granulosus geminin 0.0339 0.1577 0.1577
Brugia malayi ImpB/MucB/SamB family protein 0.015 0.0648 0.1603
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0052 0.0162 0.0377
Schistosoma mansoni lamin 0.0027 0.0037 0.0037
Schistosoma mansoni sulfide quinone reductase 0.0052 0.0162 0.0162
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0052 0.0162 0.0603
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0023 0.0057
Schistosoma mansoni rotamase 0.0133 0.0561 0.0561
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0052 0.0162 0.0603
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Echinococcus granulosus axis inhibition protein axin 0.002 0.0004 0.0004
Treponema pallidum oxidoreductase 0.0052 0.0162 0.0272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.05 0.05
Echinococcus granulosus dna polymerase kappa 0.0177 0.078 0.078
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0424 0.1995 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Brugia malayi 6-phosphofructokinase 0.0107 0.0434 0.1073
Schistosoma mansoni terminal deoxycytidyl transferase 0.015 0.0648 0.0648
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0434 0.1073
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0052 0.0162 0.0736
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0195 0.0867 0.3237
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0257 0.0635
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2912
Echinococcus granulosus lamin 0.0027 0.0037 0.0037
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0434 0.103
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0386 0.0386
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0264 0.0264
Trypanosoma brucei unspecified product 0.0171 0.0747 0.279
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0049 0.0183
Schistosoma mansoni hypothetical protein 0.0037 0.0087 0.0087
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0162 0.0342
Echinococcus granulosus lamin dm0 0.0027 0.0037 0.0037
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0196 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0052 0.0162 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0451 0.1682
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0137 0.0512
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0248 0.0585
Loa Loa (eye worm) thioredoxin reductase 0.0562 0.2679 0.6625
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0195 0.0867 0.3237
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0162 0.0342
Echinococcus multilocularis musashi 0.0027 0.0037 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2912
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0185 0.0457
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0005 0.0013
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.013 0.0545 0.2036
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0032 0.0118
Echinococcus granulosus glutamate synthase 0.0052 0.0162 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0135 0.0135
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.004 0.0106 0.0394
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0829
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0386 0.1441
Trypanosoma brucei DNA polymerase eta, putative 0.0202 0.0904 0.3374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0135 0.0135
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0166 0.0726 0.1796
Schistosoma mansoni glutamate synthase 0.0052 0.0162 0.0162
Echinococcus granulosus expressed protein 0.0133 0.0561 0.0561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0119 0.0445
Plasmodium vivax SET domain protein, putative 0.012 0.05 0.1866
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0137 0.0002
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0386 0.1441
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0829
Brugia malayi 6-phosphofructokinase 0.0107 0.0434 0.1073
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0052 0.0162 0.0134
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0195 0.0867 0.0867
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.013 0.0545 0.2036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0195 0.0867 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0049 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0933
Trypanosoma cruzi DNA damage repair protein, putative 0.0047 0.0137 0.051
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0004 0.0004
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0162 0.0603
Toxoplasma gondii selenide, water dikinase 0.0052 0.0162 0.0603
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0004
Mycobacterium ulcerans monoxygenase 0.0052 0.0162 0.0134
Onchocerca volvulus 0.012 0.05 0.101
Brugia malayi Pre-SET motif family protein 0.012 0.05 0.1236
Brugia malayi glutamate synthase 0.0052 0.0162 0.04
Schistosoma mansoni DNA polymerase IV / kappa 0.0047 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0162 0.0603
Trypanosoma cruzi NADH dehydrogenase, putative 0.0052 0.0162 0.0603
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0196 0.0732
Echinococcus multilocularis lamin dm0 0.0027 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0202 0.0904 0.2235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.05 0.05
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0933
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1283 0.623 0.8962
Trichomonas vaginalis glutamate synthase, putative 0.0052 0.0162 0.0342
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0004 0.0004
Giardia lamblia Thioredoxin reductase 0.0052 0.0162 0.0272
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0386 0.0955
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0004 0.0004
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0004 0.001
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0052 0.0162 0.0036
Schistosoma mansoni axis inhibition protein axin 0.002 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.0059 0.0196 0.0485
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0133 0.0561 0.1387
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.0855 0.0855
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0052 0.0162 0.0603
Schistosoma mansoni hypothetical protein 0.0339 0.1577 0.1577
Echinococcus multilocularis geminin 0.0339 0.1577 0.1577
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.05 0.05
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0052 0.0162 0.0162
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0049 0.0183
Trypanosoma brucei DNA polymerase IV, putative 0.0171 0.0747 0.279
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0195 0.0867 0.2145
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0144 0.0304
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0023 0.0023
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0143 0.0612 0.1514
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.1419 0.5296
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0152 0.0152
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0195 0.0867 0.3931
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0004 0.0004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0106 0.0394
Echinococcus multilocularis lamin 0.0027 0.0037 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0135 0.0333
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0434 0.162
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0162 0.0342
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0052 0.0162 0.04
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0052 0.0162 0.0162
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0195 0.0867 0.3931
Entamoeba histolytica hypothetical protein 0.0069 0.0248 0.0585
Plasmodium vivax thioredoxin reductase, putative 0.0562 0.2679 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0206 0.0509
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0424 0.1995 0.2733
Leishmania major DNA polymerase eta, putative 0.0099 0.0392 0.1465
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0185 0.0185
Brugia malayi beta-NAC-like protein 0.0069 0.0248 0.0614
Mycobacterium tuberculosis Probable oxidoreductase 0.1426 0.6936 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0434 0.103
Echinococcus multilocularis thioredoxin glutathione reductase 0.0565 0.2694 0.2694
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1419 0.5296
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0049 0.0183
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0157 0.0681 0.08
Schistosoma mansoni lamin 0.0027 0.0037 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.0202 0.0904 0.3374
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1283 0.623 0.8962
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0162 0.0603
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0052 0.0162 0.0342
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0135 0.0135
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0052 0.0162 0.0603
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0195 0.0867 0.3237
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0434 0.103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0135 0.0135
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0052 0.0162 0.04
Plasmodium falciparum DNA repair protein REV1, putative 0.0047 0.0137 0.051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0135 0.0135
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0052 0.0162 0.0134
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0137 0.1076
Mycobacterium ulcerans glutamate synthase subunit beta 0.0052 0.0162 0.0134
Mycobacterium ulcerans DNA polymerase IV 0.0177 0.078 0.3462
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0162 0.0342
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1283 0.623 0.8962
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0052 0.0162 0.0162
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0037 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0144 0.0304
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0101 0.0403 0.0996
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0185 0.007
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0052 0.0162 0.0603
Mycobacterium ulcerans NADH dehydrogenase 0.0052 0.0162 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Entamoeba histolytica deoxycytidyl transferase, putative 0.015 0.0648 0.1542
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0248 0.0927
Entamoeba histolytica hypothetical protein 0.0047 0.0137 0.0319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Brugia malayi PHD-finger family protein 0.0019 0.0001 0.0003
Brugia malayi polk-prov protein 0.0073 0.0269 0.0664
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0434 0.0434
Trypanosoma brucei chrX additional, unordered contigs 0.0047 0.0137 0.051
Onchocerca volvulus 0.0166 0.0726 0.1505
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0004 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0032 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0933
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0195 0.0867 0.3237
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0052 0.0162 0.0377
Leishmania major NADH dehydrogenase, putative 0.0052 0.0162 0.0603
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0504 0.1247
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.015 0.0648 0.1603
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0052 0.0162 0.0162
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0257 0.0257
Brugia malayi PXA domain containing protein 0.002 0.0004 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0166 0.0619
Echinococcus multilocularis glutamate synthase 0.0052 0.0162 0.0162
Plasmodium falciparum thioredoxin reductase 0.0562 0.2679 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0049 0.0183
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.015 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0073 0.0269 0.0664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.906
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0248 0.0614
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0386 0.1441
Loa Loa (eye worm) hypothetical protein 0.0166 0.0726 0.1796
Loa Loa (eye worm) RGS-3 protein 0.002 0.0004 0.001
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0137 0.0002
Echinococcus multilocularis dna polymerase eta 0.0202 0.0904 0.0904
Giardia lamblia DNA damage repair protein 0.0047 0.0137 0.0212
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0248 0.0927
Giardia lamblia DINP protein human, muc B family 0.0157 0.0681 0.1529
Schistosoma mansoni hypothetical protein 0.0339 0.1577 0.1577
Loa Loa (eye worm) glutathione reductase 0.0562 0.2679 0.6625
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0137 0.0512
Chlamydia trachomatis thioredoxin reductase 0.0052 0.0162 0.1375
Echinococcus multilocularis L aminoadipate semialdehyde 0.0166 0.0726 0.0726
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0004 0.0004
Plasmodium vivax DNA repair protein REV1, putative 0.0047 0.0137 0.051
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0052 0.0162 0.0603
Leishmania major basic transcription factor 3a, putative 0.0069 0.0248 0.0927
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0052 0.0162 0.0036
Echinococcus granulosus dna polymerase eta 0.0202 0.0904 0.0904
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0434 0.0931
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0248 0.0927
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0137 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0157 0.0681 0.2541
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0106 0.0394
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0248 0.0927
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0052 0.0162 0.0162
Trypanosoma brucei DNA polymerase IV, putative 0.0177 0.078 0.2912
Leishmania major trypanothione reductase 0.0562 0.2679 1
Echinococcus multilocularis tumor protein p63 0.034 0.1583 0.1583
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0867 0.3237
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0195 0.0867 0.3237
Plasmodium falciparum glutathione reductase 0.0562 0.2679 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0004 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0099 0.0392 0.1465
Echinococcus multilocularis dna polymerase kappa 0.0177 0.078 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2912
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0195 0.0867 0.3237
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0185 0.069
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0106 0.0394
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0196 0.0732
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0386 0.0955
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0196 0.0196
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0052 0.0162 0.0736
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0052 0.0162 0.0036
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0052 0.0162 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0135 0.0135
Echinococcus granulosus tumor protein p63 0.034 0.1583 0.1583
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0829
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0037 0.0093
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0196 0.0732
Trypanosoma cruzi NADH dehydrogenase, putative 0.0052 0.0162 0.0603
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.0071 0.0257 0.0635
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0052 0.0162 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0001 0.0004
Schistosoma mansoni kinase 0.0049 0.015 0.015
Giardia lamblia Glutamate synthase 0.0052 0.0162 0.0272
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0137 0.0415
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0309 0.0309
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.004 0.0106 0.0394
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0052 0.0162 0.0036
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0434 0.0434
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0052 0.0162 0.0134
Toxoplasma gondii hypothetical protein 0.0049 0.015 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0829
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0622 0.2323
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0137 0.051
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.05 0.05
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0119 0.0445
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0622 0.2323
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0622 0.2323
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0052 0.0162 0.0036
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0823 0.3966 0.3966
Schistosoma mansoni axis inhibition protein axin 0.002 0.0004 0.0004
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0052 0.0162 0.0134
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0004 0.001
Loa Loa (eye worm) programmed cell death 8 0.0052 0.0162 0.04
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.013 0.0545 0.2036
Echinococcus granulosus transcription factor btf3 0.0069 0.0248 0.0248
Plasmodium falciparum ferrodoxin reductase-like protein 0.0052 0.0162 0.0603
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2912
Loa Loa (eye worm) hypothetical protein 0.012 0.05 0.1236
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0829
Mycobacterium ulcerans hypothetical protein 0.0052 0.0162 0.0134
Schistosoma mansoni disulfide oxidoreductase 0.0052 0.0162 0.0162
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0434 0.1073
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0185 0.0185
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0001 0.0004
Entamoeba histolytica disulphide oxidoreductase, putative 0.0052 0.0162 0.0377
Leishmania major hypothetical protein, conserved 0.0052 0.0162 0.0603
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0052 0.0162 0.0603
Loa Loa (eye worm) hypothetical protein 0.0052 0.0162 0.04
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0052 0.0162 0.0036
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0195 0.0867 0.3237
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0052 0.0162 0.04
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0052 0.0162 0.0162
Trichomonas vaginalis DNA polymerase eta, putative 0.0177 0.078 0.1683
Loa Loa (eye worm) hypothetical protein 0.005 0.0152 0.0376
Trichomonas vaginalis glutamate synthase, putative 0.0052 0.0162 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0451 0.1682
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0195 0.0867 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0839 0.4043 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0133 0.0561 0.1387
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0004
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0196 0.0196
Mycobacterium tuberculosis Conserved hypothetical protein 0.015 0.0648 0.0752
Leishmania major DNA damage repair protein, putative 0.0047 0.0137 0.051
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0004 0.0004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10.8 uM Inhibition of human TMEM16A transfected in FRT cells assessed as iodide influx using YFP-F46L/H148Q/I152L halide sensor after 10 mins by spectrofluorometric analysis ChEMBL. 22739085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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