Detailed information for compound 1656960

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 251.321 | Formula: C14H21NO3
  • H donors: 1 H acceptors: 1 LogP: 3.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(COc1ccccc1OC(=O)NC)CC
  • InChi: 1S/C14H21NO3/c1-4-11(5-2)10-17-12-8-6-7-9-13(12)18-14(16)15-3/h6-9,11H,4-5,10H2,1-3H3,(H,15,16)
  • InChiKey: YPUHTLZQBKFOOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii alpha-tubulin I, putative 0.0268 0.1291 0.4789
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0063
Schistosoma mansoni tubulin subunit alpha 0.0268 0.1291 0.6612
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.001
Echinococcus granulosus tubulin alpha 1C chain 0.0268 0.1291 0.6614
Echinococcus multilocularis hypothetical protein 0.0268 0.1291 0.1532
Plasmodium vivax tubulin beta chain, putative 0.0144 0.067 0.2486
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0659 0.0782
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Schistosoma mansoni hypothetical protein 0.0137 0.0634 0.3248
Leishmania major beta tubulin 0.0144 0.067 0.2486
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0039 0.0071
Mycobacterium tuberculosis Possible oxidoreductase 0.0082 0.0357 0.0665
Loa Loa (eye worm) RNA binding protein 0.013 0.0599 0.4026
Plasmodium falciparum protoporphyrinogen oxidase 0.0082 0.0357 0.1323
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0384 0.2969
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0074 0.027
Plasmodium vivax tubulin alpha chain, putative 0.0268 0.1291 0.4789
Brugia malayi Importin beta-1 subunit 0.0029 0.0092 0.0125
Loa Loa (eye worm) tubulin alpha 2 0.0206 0.0977 0.6562
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.0262 0.0967
Onchocerca volvulus 0.0012 0.0009 0.0008
Onchocerca volvulus 0.0028 0.0088 0.0087
Echinococcus granulosus dnaJ subfamily B 0.04 0.1951 1
Echinococcus multilocularis Niemann Pick C1 protein 0.029 0.14 0.1662
Echinococcus multilocularis tubulin alpha chain 0.0268 0.1291 0.1532
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0152 0.1166
Leishmania major hypothetical protein, conserved 0.0025 0.0074 0.027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0645 0.239
Schistosoma mansoni hypothetical protein 0.0064 0.0266 0.1356
Brugia malayi Tubulin beta chain 0.0063 0.0262 0.0359
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0001 0.0002
Leishmania major beta tubulin 0.0144 0.067 0.2486
Loa Loa (eye worm) hypothetical protein 0.0203 0.0964 0.6478
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0952 0.6398
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Leishmania major gamma-tubulin 0.0144 0.067 0.2486
Leishmania major beta tubulin 0.0144 0.067 0.2486
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0634 0.0873
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Entamoeba histolytica tubulin gamma chain 0.0144 0.067 0.5191
Brugia malayi SWIRM domain containing protein 0.0082 0.0357 0.0491
Echinococcus granulosus geminin 0.0167 0.0785 0.4024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0659 0.0782
Schistosoma mansoni DNA ligase IV 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0518
Trichomonas vaginalis tubulin epsilon chain, putative 0.0063 0.0262 0.202
Plasmodium vivax tubulin gamma chain, putative 0.0144 0.067 0.2486
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.0678 0.4553
Loa Loa (eye worm) BEN-1 protein 0.0144 0.067 0.4504
Echinococcus granulosus nibrin 0.0011 0.0001 0.0008
Onchocerca volvulus 0.0012 0.0009 0.0008
Echinococcus granulosus tubulin alpha 0.0144 0.067 0.3436
Entamoeba histolytica hypothetical protein 0.0011 0.0001 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.02 0.0738
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Leishmania major beta tubulin 0.0144 0.067 0.2486
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1694 0.8427 1
Brugia malayi hypothetical protein 0.0025 0.0074 0.01
Brugia malayi Telomerase reverse transcriptase 0.146 0.7254 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0082 0.0357 0.1831
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0031
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0417 0.2139
Leishmania major beta tubulin 0.0144 0.067 0.2486
Echinococcus multilocularis snurportin 1 0.0308 0.1489 0.1766
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0077 0.0589
Leishmania major UDP-galactopyranose mutase 0.0082 0.0357 0.1323
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0203 0.0964 0.1144
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.027
Mycobacterium ulcerans hypothetical protein 0.0155 0.0724 0.1254
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0313 0.1516 0.263
Chlamydia trachomatis DNA ligase 0.0011 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0002
Trypanosoma brucei beta tubulin 0.0144 0.067 0.2485
Echinococcus granulosus tubulin beta 4A class IVa 0.0144 0.067 0.3436
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0266 0.1361
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Schistosoma mansoni tar DNA-binding protein 0.013 0.0599 0.3067
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0266 0.1785
Echinococcus multilocularis 0.0045 0.0174 0.0206
Trypanosoma brucei beta tubulin 0.0144 0.067 0.2485
Echinococcus multilocularis protein patched 0.0087 0.0384 0.0456
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0065 0.0235
Schistosoma mansoni tubulin subunit beta 0.0144 0.067 0.3432
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0659 0.4427
Echinococcus granulosus tubulin beta 1 chain 0.0144 0.067 0.3436
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0044 0.0285
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0313 0.1516 0.2832
Loa Loa (eye worm) hypothetical protein 0.0033 0.0112 0.0754
Echinococcus multilocularis protein dispatched 1 0.0099 0.0446 0.0529
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0065 0.0494
Loa Loa (eye worm) TAR-binding protein 0.013 0.0599 0.4026
Schistosoma mansoni amine oxidase 0.0082 0.0357 0.1826
Loa Loa (eye worm) beta-tubulin 0.0144 0.067 0.4504
Onchocerca volvulus Protein patched homolog 0.0012 0.0009 0.0008
Brugia malayi CXXC zinc finger family protein 0.0028 0.0088 0.012
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0001 0.0006
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0077 0.0589
Echinococcus granulosus tubulin alpha 3 chain 0.0268 0.1291 0.6614
Loa Loa (eye worm) hypothetical protein 0.0097 0.0434 0.2913
Toxoplasma gondii beta-1 tubulin, putative 0.0144 0.067 0.2486
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0039 0.0071
Giardia lamblia Beta tubulin 0.0144 0.067 0.2485
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0077 0.0105
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0549 0.2693 1
Trypanosoma cruzi tubulin delta chain 0.0063 0.0262 0.0966
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0044 0.0161
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Schistosoma mansoni tubulin subunit gamma 0.0144 0.067 0.3432
Trichomonas vaginalis tubulin, putative 0.0082 0.0357 0.2758
Schistosoma mansoni hypothetical protein 0.0084 0.0368 0.1883
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Toxoplasma gondii histone lysine-specific demethylase 0.0082 0.0357 0.1323
Loa Loa (eye worm) tubulin gamma chain 0.0144 0.067 0.4504
Echinococcus granulosus Tubulin beta 2C chain 0.0144 0.067 0.3436
Leishmania major beta tubulin 0.0144 0.067 0.2486
Chlamydia trachomatis protoporphyrinogen oxidase 0.0082 0.0357 0.235
Toxoplasma gondii beta-tubulin, putative 0.0144 0.067 0.2486
Echinococcus multilocularis Tubulin beta 2C chain 0.0144 0.067 0.0796
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Plasmodium falciparum alpha tubulin 2 0.0268 0.1291 0.4789
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0384 0.1968
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0082 0.0357 0.0424
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0001 0.0008
Echinococcus multilocularis geminin 0.0167 0.0785 0.0932
Echinococcus granulosus GPCR family 2 0.0064 0.0266 0.1361
Trichomonas vaginalis tubulin beta chain, putative 0.0268 0.1291 1
Schistosoma mansoni topbp1 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0201 0.0952 0.6398
Plasmodium falciparum telomerase reverse transcriptase 0.0549 0.2693 1
Leishmania major beta tubulin 0.0144 0.067 0.2486
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0001 0.0006
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.0678 0.0804
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.1421 0.5272
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0031
Echinococcus granulosus tubulin delta chain 0.0063 0.0262 0.1341
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0082 0.0357 0.24
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0152 0.1166
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0434 0.2218
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0549 0.2693 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0336 0.1716
Schistosoma mansoni alpha tubulin 0.0268 0.1291 0.6612
Brugia malayi Cell division protein ftsZ 0.0063 0.0262 0.0359
Trichomonas vaginalis tubulin beta chain, putative 0.0082 0.0357 0.2758
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0266 0.0365
Loa Loa (eye worm) tubulin beta-1 chain 0.0144 0.067 0.4504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0659 0.3378
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0077 0.2124
Trichomonas vaginalis tubulin beta chain, putative 0.0268 0.1291 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0262 0.202
Trypanosoma brucei epsilon tubulin 0.0144 0.067 0.2485
Schistosoma mansoni hypothetical protein 0.0039 0.0144 0.0732
Schistosoma mansoni transient receptor potential channel 0.0064 0.0269 0.1374
Trichomonas vaginalis tubulin beta chain, putative 0.0268 0.1291 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0001 0.0001
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0128 0.0176
Onchocerca volvulus 0.0012 0.0009 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0266 0.0315
Trypanosoma brucei alpha tubulin 0.0268 0.1291 0.4789
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0077 0.0131
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0181 0.0215
Schistosoma mansoni cpg binding protein 0.0028 0.0088 0.0448
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0152 0.1166
Schistosoma mansoni hypothetical protein 0.0084 0.0368 0.1883
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0082 0.0357 0.1826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.034 0.1742
Echinococcus multilocularis 0.0082 0.0357 0.0424
Brugia malayi hypothetical protein 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0518
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0077 0.0131
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0082 0.0357 0.24
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Brugia malayi beta-tubulin, identical 0.0144 0.067 0.0923
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Brugia malayi amine oxidase, flavin-containing family protein 0.0082 0.0357 0.0491
Loa Loa (eye worm) hypothetical protein 0.0107 0.0482 0.3239
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0063 0.0262 0.202
Trichomonas vaginalis tubulin, putative 0.0082 0.0357 0.2758
Brugia malayi Patched related family protein 12 0.0012 0.0009 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0659 0.3374
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0088 0.0594
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0073
Schistosoma mansoni tubulin subunit beta 0.0144 0.067 0.3432
Leishmania major beta tubulin 0.0144 0.067 0.2486
Onchocerca volvulus 0.0012 0.0009 0.0008
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0001 0.0006
Brugia malayi hypothetical protein 0.0082 0.0357 0.0491
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Echinococcus multilocularis nibrin 0.0011 0.0001 0.0002
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0357 0.2758
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0313 0.1516 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0298
Brugia malayi hypothetical protein 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trichomonas vaginalis tubulin epsilon chain, putative 0.0144 0.067 0.5191
Trypanosoma brucei epsilon tubulin 0.0144 0.067 0.2485
Schistosoma mansoni tubulin subunit epsilon 0.0144 0.067 0.3432
Brugia malayi Patched related family protein 10 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0155 0.057
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1162 0.5762 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0253 0.1699
Giardia lamblia Alpha-tubulin 0.0268 0.1291 0.4789
Schistosoma mansoni hypothetical protein 0.0308 0.1489 0.7627
Trypanosoma brucei alpha tubulin 0.0268 0.1291 0.4789
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0384 0.258
Brugia malayi hypothetical protein 0.0012 0.0009 0.0011
Loa Loa (eye worm) tubulin beta chain 0.0063 0.0262 0.1757
Echinococcus granulosus alpha tubulin 0.0268 0.1291 0.6614
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0001 0.0001
Brugia malayi Patched protein homolog 1 0.0012 0.0009 0.0011
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0082 0.0357 0.1323
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0144 0.0171
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0001 0.0001
Leishmania major beta tubulin 0.0144 0.067 0.2486
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Echinococcus granulosus Tubulin beta 2C chain 0.0144 0.067 0.3436
Schistosoma mansoni tar DNA-binding protein 0.013 0.0599 0.3067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0724 0.135
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0298
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0077 0.0131
Echinococcus multilocularis Tubulin alpha 1 chain 0.0268 0.1291 0.1532
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0001 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0384 0.1968
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0077 0.0589
Brugia malayi hypothetical protein 0.0039 0.0144 0.0197
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0031
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0357 0.1323
Echinococcus granulosus Tubulin beta 2C chain 0.0144 0.067 0.3436
Echinococcus granulosus tubulin alpha chain 0.0268 0.1291 0.6614
Schistosoma mansoni tar DNA-binding protein 0.013 0.0599 0.3067
Mycobacterium ulcerans oxidoreductase 0.0082 0.0357 0.0618
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0518
Schistosoma mansoni ran 0.0021 0.0054 0.0271
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0077 0.0105
Echinococcus multilocularis tubulin alpha chain 0.0268 0.1291 0.1532
Giardia lamblia Beta tubulin 0.0144 0.067 0.2485
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0077 0.0282
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.067 0.5191
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0206 0.098 0.502
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0001 0.0006
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0128 0.0658
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.0357 0.0665
Plasmodium vivax importin-beta 2, putative 0.0029 0.0092 0.0338
Loa Loa (eye worm) hypothetical protein 0.0187 0.0882 0.5923
Leishmania major epsilon tubulin, putative 0.0144 0.067 0.2486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0952 0.1311
Echinococcus granulosus cpg binding protein 0.003 0.0096 0.0494
Echinococcus granulosus tubulin gamma 1 chain 0.0144 0.067 0.3436
Echinococcus granulosus Tubulin beta 2C chain 0.0144 0.067 0.3436
Loa Loa (eye worm) hypothetical protein 0.0082 0.0357 0.24
Toxoplasma gondii beta tubulin 0.0144 0.067 0.2486
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0298
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0077 0.0131
Leishmania major zeta tubulin, putative 0.0063 0.0262 0.0967
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0269 0.0319
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0054 0.0277
Trichomonas vaginalis tubulin, putative 0.0144 0.067 0.5191
Schistosoma mansoni tyrosine kinase 0.0047 0.0181 0.0922
Trypanosoma cruzi beta tubulin, putative 0.0144 0.067 0.2485
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0645 0.239
Trypanosoma brucei zeta tubulin, putative 0.0063 0.0262 0.0966
Schistosoma mansoni hypothetical protein 0.0167 0.0785 0.402
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0269 0.1379
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0054 0.0196
Giardia lamblia Delta tubulin 0.0063 0.0262 0.0966
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0039 0.0071
Schistosoma mansoni tyrosine kinase 0.0078 0.034 0.1737
Brugia malayi hypothetical protein 0.0012 0.0009 0.0011
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.034 0.0403
Brugia malayi Tubulin beta chain 0.0082 0.0357 0.049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trichomonas vaginalis tubulin beta chain, putative 0.0268 0.1291 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0155 0.057
Trypanosoma brucei alpha tubulin 0.0268 0.1291 0.4789
Trypanosoma brucei telomerase reverse transcriptase 0.0549 0.2693 1
Echinococcus multilocularis tubulin beta 1 chain 0.0144 0.067 0.0796
Brugia malayi Niemann-Pick C1 protein precursor 0.0203 0.0964 0.1328
Echinococcus granulosus tar DNA binding protein 0.013 0.0599 0.3072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Echinococcus multilocularis tubulin alpha chain 0.0268 0.1291 0.1532
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Trypanosoma cruzi UDP-galactopyranose mutase 0.0082 0.0357 0.1322
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0313 0.1516 0.5628
Echinococcus granulosus lysine specific histone demethylase 1A 0.0082 0.0357 0.1831
Trypanosoma cruzi epsilon tubulin, putative 0.0144 0.067 0.2485
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0196
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0063
Trichomonas vaginalis tubulin gamma chain, putative 0.0063 0.0262 0.202
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0082 0.0357 1
Toxoplasma gondii hypothetical protein 0.0047 0.0185 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0002
Trypanosoma brucei beta tubulin 0.0144 0.067 0.2485
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0357 0.2758
Trypanosoma cruzi UDP-galactopyranose mutase 0.0082 0.0357 0.1322
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0074 0.0269
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Echinococcus granulosus Niemann Pick C1 protein 0.029 0.14 0.7178
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0155 0.057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0659 0.3378
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0645 0.2391
Loa Loa (eye worm) hypothetical protein 0.0082 0.0357 0.24
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0063 0.0262 0.1717
Trypanosoma cruzi epsilon tubulin, putative 0.0144 0.067 0.2485
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0001 0.0001
Trypanosoma brucei epsilon tubulin 0.0144 0.067 0.2485
Loa Loa (eye worm) hypothetical protein 0.0064 0.0266 0.1785
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0128 0.0152
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.001
Onchocerca volvulus 0.0012 0.0009 0.0008
Loa Loa (eye worm) tubulin beta-4 chain 0.0144 0.067 0.4504
Schistosoma mansoni tar DNA-binding protein 0.013 0.0599 0.3067
Echinococcus multilocularis tubulin alpha 3 chain 0.0268 0.1291 0.1532
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0002
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0417 0.0495
Schistosoma mansoni tubulin subunit beta 0.0063 0.0262 0.1336
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0092 0.0338
Trypanosoma brucei beta tubulin 0.0144 0.067 0.2485
Schistosoma mansoni tar DNA-binding protein 0.013 0.0599 0.3067
Brugia malayi tubulin alpha chain - mouse 0.0268 0.1291 0.1778
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0044 0.0081
Echinococcus multilocularis tubulin alpha chain 0.0268 0.1291 0.1532
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0268 0.1291 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0144 0.067 0.0796
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Echinococcus multilocularis cpg binding protein 0.003 0.0096 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.1421 0.5272
Schistosoma mansoni tubulin subunit beta 0.0144 0.067 0.3432
Schistosoma mansoni hypothetical protein 0.0084 0.0368 0.1883
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.001
Brugia malayi Tubulin beta-1 chain 0.0144 0.067 0.0923
Trypanosoma brucei alpha tubulin 0.0268 0.1291 0.4789
Plasmodium falciparum tubulin beta chain 0.0144 0.067 0.2486
Schistosoma mansoni amine oxidase 0.0082 0.0357 0.1826
Trichomonas vaginalis tubulin beta chain, putative 0.0268 0.1291 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0144 0.067 0.0796
Leishmania major delta tubulin, putative 0.0063 0.0262 0.0967
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0434 0.0515
Plasmodium vivax patched family protein, putative 0.0012 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0206 0.0977 0.6562
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.034 0.1742
Leishmania major beta tubulin 0.0144 0.067 0.2486
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0074 0.027
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0001 0.0002
Toxoplasma gondii hypothetical protein 0.0012 0.0009 0.0031
Brugia malayi Tubulin alpha-2 chain 0.0268 0.1291 0.1778
Brugia malayi alpha-tubulin 0.0268 0.1291 0.1778
Plasmodium falciparum importin beta, putative 0.0029 0.0092 0.0338
Echinococcus multilocularis Tubulin beta 2C chain 0.0144 0.067 0.0796
Trichomonas vaginalis tubulin, putative 0.0063 0.0262 0.202
Echinococcus multilocularis tubulin alpha 1C chain 0.0268 0.1291 0.1532
Echinococcus multilocularis Tubulin alpha 1 chain 0.0268 0.1291 0.1532
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0497
Trichomonas vaginalis tubulin gamma chain, putative 0.0144 0.067 0.5191
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0363
Schistosoma mansoni transient receptor potential channel 0.0097 0.0434 0.2218
Schistosoma mansoni cpg binding protein 0.003 0.0096 0.0489
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0063
Schistosoma mansoni tyrosine kinase 0.0078 0.034 0.1737
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0082 0.0357 0.1826
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0077 0.0131
Echinococcus granulosus tubulin epsilon chain 0.0144 0.067 0.3436
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0144 0.0738
Onchocerca volvulus 0.0026 0.0077 0.0076
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0952 0.1311
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.0678 0.0933
Echinococcus multilocularis tar DNA binding protein 0.013 0.0599 0.0711
Mycobacterium tuberculosis Cell division protein FtsZ 0.0063 0.0262 0.0487
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Brugia malayi RNA binding protein 0.013 0.0599 0.0825
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0077 0.0282
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0266 0.0315
Schistosoma mansoni tubulin subunit beta 0.0144 0.067 0.3432
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0619
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0001 0.0008
Trichomonas vaginalis tubulin gamma chain, putative 0.0144 0.067 0.5191
Echinococcus granulosus tubulin subunit TubB 0.0268 0.1291 0.6614
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) tubulin alpha chain 0.0268 0.1291 0.867
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Mycobacterium leprae cell division protein FtsZ 0.0063 0.0262 0.7311
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) tubulin alpha chain 0.0268 0.1291 0.867
Brugia malayi Tubulin alpha-2 chain 0.0268 0.1291 0.1778
Brugia malayi Protein kinase domain containing protein 0.0047 0.0181 0.0248
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0054 0.0196
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0262 0.202
Loa Loa (eye worm) hypothetical protein 0.0082 0.0357 0.24
Echinococcus multilocularis tubulin subunit beta 0.0144 0.067 0.0796
Brugia malayi Tubulin alpha chain 0.0063 0.0262 0.0359
Echinococcus granulosus importin subunit beta 1 0.0029 0.0092 0.0472
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.0678 0.3473
Schistosoma mansoni tubulin subunit beta 0.0144 0.067 0.3432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Echinococcus granulosus Tubulin alpha 1 chain 0.0268 0.1291 0.6614
Leishmania major beta tubulin 0.0144 0.067 0.2486
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0001 0.0001
Echinococcus multilocularis protoporphyrinogen oxidase 0.0082 0.0357 0.0424
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0384 0.0456
Plasmodium falciparum tubulin epsilon chain, putative 0.0144 0.067 0.2486
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0039 0.0144 0.1107
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0001 0.0006
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.0262 0.0967
Echinococcus granulosus expressed conserved protein 0.0191 0.0903 0.4626
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trichomonas vaginalis tubulin epsilon chain, putative 0.0268 0.1291 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0054 0.041
Giardia lamblia Alpha-tubulin 0.0268 0.1291 0.4789
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0001 0.0002
Echinococcus granulosus tubulin alpha 1C chain 0.0268 0.1291 0.6614
Giardia lamblia Telomerase catalytic subunit 0.0549 0.2693 1
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Echinococcus multilocularis Tubulin beta 2C chain 0.0144 0.067 0.0796
Echinococcus multilocularis tubulin alpha 1C chain 0.0268 0.1291 0.1532
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0434 0.2222
Plasmodium vivax telomerase reverse transcriptase, putative 0.0549 0.2693 1
Schistosoma mansoni tyrosine kinase 0.0047 0.0181 0.0922
Entamoeba histolytica hypothetical protein 0.0023 0.0065 0.0494
Echinococcus multilocularis tubulin delta chain 0.0063 0.0262 0.031
Echinococcus granulosus tubulin alpha chain 0.0268 0.1291 0.6614
Loa Loa (eye worm) tubulin alpha-2 chain 0.0268 0.1291 0.867
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0659 0.3374
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0144 0.067 0.2486
Echinococcus granulosus Tubulin alpha 1 chain 0.0268 0.1291 0.6614
Schistosoma mansoni alpha tubulin 0.0268 0.1291 0.6612
Echinococcus granulosus insulin receptor 0.0047 0.0181 0.0928
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0077 0.0131
Trypanosoma brucei tubulin gamma chain 0.0144 0.067 0.2485
Echinococcus multilocularis Tubulin alpha 1 chain 0.0268 0.1291 0.1532
Leishmania major importin beta-1 subunit, putative 0.0023 0.0065 0.0237
Giardia lamblia Beta tubulin 0.0144 0.067 0.2485
Echinococcus multilocularis dnaJ subfamily B 0.04 0.1951 0.2315
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.027
Schistosoma mansoni hypothetical protein 0.0064 0.0266 0.1356
Echinococcus granulosus Niemann Pick C1 protein 0.0203 0.0964 0.4942
Loa Loa (eye worm) alpha-tubulin 0.0268 0.1291 0.867
Loa Loa (eye worm) BEN-1 protein 0.0144 0.067 0.4504
Mycobacterium ulcerans dehydrogenase 0.0082 0.0357 0.0618
Echinococcus multilocularis expressed conserved protein 0.0191 0.0903 0.1071
Echinococcus granulosus Tubulin alpha 1 chain 0.0268 0.1291 0.6614
Brugia malayi TAR-binding protein 0.013 0.0599 0.0825
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Brugia malayi Tubulin alpha chain 0.0268 0.1291 0.1778
Leishmania major telomerase reverse transcriptase, putative 0.0549 0.2693 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0044 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0077 0.2124
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0266 0.0365
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0195
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0144 0.067 0.0796
Echinococcus multilocularis beta tubulin 0.0144 0.067 0.0796
Loa Loa (eye worm) tubulin beta-2A chain 0.0144 0.067 0.4504
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0063
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0065 0.0494
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0313 0.1516 0.263
Plasmodium vivax tubulin alpha chain, putative 0.0268 0.1291 0.4789
Schistosoma mansoni tyrosine kinase 0.0146 0.0678 0.3469
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0065 0.0494
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Plasmodium vivax tubulin epsilon chain, putative 0.0144 0.067 0.2486
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0054 0.0064
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0017
Onchocerca volvulus 0.0012 0.0009 0.0008
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Leishmania major beta tubulin 0.0144 0.067 0.2486
Schistosoma mansoni tubulin subunit alpha 0.0268 0.1291 0.6612
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0082 0.0357 0.1323
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0082 0.0357 0.0618
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) hypothetical protein 0.0268 0.1291 0.867
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0092 0.0109
Echinococcus multilocularis tubulin alpha chain 0.0268 0.1291 0.1532
Entamoeba histolytica hypothetical protein 0.0039 0.0144 0.1107
Entamoeba histolytica hypothetical protein 0.0039 0.0144 0.1107
Schistosoma mansoni hypothetical protein 0.0167 0.0785 0.402
Schistosoma mansoni hypothetical protein 0.0084 0.0368 0.1883
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0001 0.0001
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0313 0.1516 0.5628
Leishmania major beta tubulin 0.0144 0.067 0.2486
Brugia malayi Tubulin gamma chain 0.0144 0.067 0.0923
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0246 0.1256
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.067 0.5191
Trichomonas vaginalis tubulin beta chain, putative 0.0268 0.1291 1
Schistosoma mansoni tubulin subunit alpha 0.0268 0.1291 0.6612
Entamoeba histolytica tubulin family protein 0.0144 0.067 0.5191
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0001 0.0002
Onchocerca volvulus Protein patched homolog 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0298
Echinococcus multilocularis beta tubulin 0.0144 0.067 0.0796
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0203 0.0964 0.747
Giardia lamblia Gamma tubulin 0.0144 0.067 0.2485
Schistosoma mansoni tubulin subunit delta 0.0063 0.0262 0.1336
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0092 0.0337
Echinococcus multilocularis tubulin epsilon chain 0.0144 0.067 0.0796
Echinococcus granulosus snurportin 1 0.0308 0.1489 0.7629
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0206 0.0977 0.6562
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.1421 0.5273
Giardia lamblia Epsilon tubulin 0.0063 0.0262 0.0966
Treponema pallidum cell division protein FtsZ 0.0063 0.0262 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0001 0.0002
Echinococcus multilocularis tubulin alpha 0.0144 0.067 0.0796
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0181 0.1216
Echinococcus granulosus peroxisome assembly protein 26 0.0268 0.1291 0.6614
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.1421 0.5272
Echinococcus granulosus tubulin alpha chain 0.0268 0.1291 0.6614
Loa Loa (eye worm) hypothetical protein 0.0087 0.0384 0.258
Trichomonas vaginalis tubulin epsilon chain, putative 0.0268 0.1291 1
Entamoeba histolytica hypothetical protein 0.0039 0.0144 0.1107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trypanosoma cruzi zeta tubulin, putative 0.0063 0.0262 0.0966
Brugia malayi protein C24B5.3 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Loa Loa (eye worm) tubulin alpha 2 0.0206 0.0977 0.6562
Leishmania major beta tubulin 0.0144 0.067 0.2486
Trichomonas vaginalis tubulin beta chain, putative 0.0144 0.067 0.5191
Echinococcus multilocularis tubulin subunit TubB 0.0268 0.1291 0.1532
Loa Loa (eye worm) tubulin beta chain 0.0144 0.067 0.4504
Schistosoma mansoni hypothetical protein 0.0064 0.0266 0.1356
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0082 0.0357 0.1323
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0077 0.0105
Echinococcus multilocularis GPCR, family 2 0.0064 0.0266 0.0315
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0077 0.0131
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Schistosoma mansoni cpg binding protein 0.003 0.0096 0.0489
Trypanosoma brucei zeta tubulin 0.0063 0.0262 0.0966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0659 0.3374
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0187 0.0882 0.6829
Onchocerca volvulus 0.0082 0.0357 0.0356
Brugia malayi Myosin head containing protein 0.0012 0.0009 0.0011
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.108 0.5352 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0044 0.0161
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0001 0.0002
Echinococcus multilocularis peroxisome assembly protein 26 0.0268 0.1291 0.1532
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0599 0.0825
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Echinococcus granulosus beta tubulin 0.0144 0.067 0.3436
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0313 0.1516 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0082 0.0357 0.2758
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0144 0.0732
Schistosoma mansoni hypothetical protein 0.04 0.1951 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0206 0.0977 0.7566
Leishmania major beta tubulin 0.0144 0.067 0.2486
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0313 0.1516 0.263
Leishmania major beta tubulin 0.0144 0.067 0.2486
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0152 0.1166
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0004 0.0005
Brugia malayi protein C24B5.3 0.0012 0.0009 0.0011
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0155 0.057
Schistosoma mansoni alpha tubulin 0.0268 0.1291 0.6612
Plasmodium falciparum tubulin gamma chain 0.0144 0.067 0.2486
Echinococcus granulosus Tubulin beta 2C chain 0.0144 0.067 0.3436
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0181 0.0928
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.0195
Entamoeba histolytica tubulin family protein 0.0144 0.067 0.5191
Loa Loa (eye worm) hypothetical protein 0.0137 0.0634 0.4263
Entamoeba histolytica tubulin alpha chain, putative 0.0268 0.1291 1
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Mycobacterium ulcerans monoamine oxidase 0.0082 0.0357 0.0618
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0092 0.0337
Schistosoma mansoni tubulin subunit beta 0.0144 0.067 0.3432
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0863
Toxoplasma gondii alpha tubulin TUBA1 0.0268 0.1291 0.4789
Echinococcus granulosus tubulin alpha 3 chain 0.0268 0.1291 0.6614
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0357 0.2758
Loa Loa (eye worm) hypothetical protein 0.0082 0.0357 0.24
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0001 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0077 0.0142
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0214 0.0792
Mycobacterium ulcerans hypothetical protein 0.0026 0.0077 0.0131
Echinococcus multilocularis insulin receptor 0.0047 0.0181 0.0215
Schistosoma mansoni transient receptor potential channel 0.0064 0.0269 0.1374
Onchocerca volvulus 0.0012 0.0009 0.0008
Echinococcus granulosus tubulin subunit beta 0.0144 0.067 0.3436
Toxoplasma gondii RNA-directed DNA polymerase 0.0549 0.2693 1
Brugia malayi RNA, U transporter 1 0.0082 0.0358 0.0492
Plasmodium falciparum alpha tubulin 1 0.0268 0.1291 0.4789
Loa Loa (eye worm) alpha-tubulin 0.0268 0.1291 0.867
Loa Loa (eye worm) tubulin alpha 2 0.0124 0.0568 0.3815
Leishmania major alpha tubulin 0.0268 0.1291 0.4789
Schistosoma mansoni topbp1 0.0011 0.0001 0.0002
Trichomonas vaginalis tubulin epsilon chain, putative 0.0144 0.067 0.5191
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0077 0.0282
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0266 0.1361
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0031
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0001 0.0001
Trichomonas vaginalis tubulin gamma chain, putative 0.0144 0.067 0.5191
Echinococcus granulosus tubulin alpha chain 0.0268 0.1291 0.6614
Brugia malayi hypothetical protein 0.0016 0.0029 0.0039
Trypanosoma cruzi tubulin delta chain 0.0063 0.0262 0.0966
Leishmania major beta tubulin 0.0144 0.067 0.2486
Trypanosoma brucei tubulin delta chain 0.0063 0.0262 0.0966
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0269 0.0319
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.1489 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0063
Trypanosoma cruzi alpha tubulin, putative 0.0268 0.1291 0.4789
Schistosoma mansoni tyrosine kinase 0.0078 0.0336 0.1716
Schistosoma mansoni tubulin subunit alpha 0.0063 0.0262 0.1336
Plasmodium vivax delta tubulin, putative 0.0063 0.0262 0.0967
Schistosoma mansoni patched 1 0.0087 0.0384 0.1963
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0001 0.0006
Echinococcus granulosus beta tubulin 0.0144 0.067 0.3436
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.0357 0.1323
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0659 0.0907
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0152 0.1166
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0001 0.0001
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1162 0.5762 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0336 0.1716
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0195
Onchocerca volvulus 0.0082 0.0357 0.0356
Brugia malayi Patched family protein 0.0012 0.0009 0.0011
Trypanosoma cruzi zeta tubulin, putative 0.0063 0.0262 0.0966
Echinococcus granulosus tubulin alpha chain 0.0268 0.1291 0.6614
Trypanosoma brucei alpha tubulin, putative 0.0082 0.0357 0.132
Schistosoma mansoni ran 0.0021 0.0054 0.0271
Trypanosoma brucei beta tubulin 0.0144 0.067 0.2485
Trichomonas vaginalis ran, putative 0.0021 0.0054 0.041
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0269 0.1379
Leishmania major GTP-binding protein, putative 0.0021 0.0054 0.0196
Echinococcus multilocularis tubulin gamma 1 chain 0.0144 0.067 0.0796
Brugia malayi Patched related family protein 4 0.0012 0.0009 0.0011
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0077 0.0142
Plasmodium falciparum tubulin delta chain, putative 0.0063 0.0262 0.0967
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0001 0.0001
Brugia malayi tubulin alpha-2 chain 0.0268 0.1291 0.1778
Mycobacterium ulcerans cell division protein FtsZ 0.0063 0.0262 0.0452
Leishmania major beta tubulin 0.0144 0.067 0.2486
Schistosoma mansoni hypothetical protein 0.0064 0.0266 0.1356
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0084 0.0366 0.1354
Entamoeba histolytica tubulin alpha-1 chain 0.0268 0.1291 1
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0357 0.1323
Echinococcus multilocularis tubulin alpha 3 chain 0.0268 0.1291 0.1532
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0004 0.0022
Loa Loa (eye worm) tubulin alpha-3 chain 0.0187 0.0882 0.5923
Brugia malayi CHE-14 protein 0.0087 0.0384 0.0528
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0039 0.0071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0599 0.4026
Schistosoma mansoni importin beta-1 0.0029 0.0092 0.0467
Trypanosoma cruzi tubulin gamma chain 0.0144 0.067 0.2485

Activities

Activity type Activity value Assay description Source Reference
Kinact (binding) = 0.48 /mM/min Inhibition of human recombinant AChE after 6 mins by Ellman assay ChEMBL. 22738634
Kinact (binding) = 255 /mM/min Inhibition of Anopheles gambiae AChE expressed in Escherichia coli after 6 mins by Ellman assay ChEMBL. 22738634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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