Detailed information for compound 170867

Basic information

Technical information
  • TDR Targets ID: 170867
  • Name: (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-tr imethoxyphenyl)prop-2-enenitrile
  • MW: 341.358 | Formula: C19H19NO5
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C/c1ccc(c(c1)O)OC)/c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C19H19NO5/c1-22-16-6-5-12(8-15(16)21)7-14(11-20)13-9-17(23-2)19(25-4)18(10-13)24-3/h5-10,21H,1-4H3/b14-7-
  • InChiKey: GBUWWCAJZNCFFA-AUWJEWJLSA-N  


Substructure search Similarity search

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Synonyms

  • (E)-3-(3-hydroxy-4-methoxy-phenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enenitrile
  • (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-2-propenenitrile
  • (E)-3-(3-hydroxy-4-methoxy-phenyl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 4A class IVa No references
Homo sapiens tubulin, alpha 3d No references
Bos taurus Tubulin Starlite/ChEMBL References
Homo sapiens tubulin, beta 8 class VIII No references
Homo sapiens tubulin, alpha 1b No references
Homo sapiens tubulin, beta 1 class VI No references
Homo sapiens tubulin, alpha 1a No references
Homo sapiens tubulin, alpha 4a No references
Homo sapiens tubulin, beta 4B class IVb No references
Homo sapiens tubulin, beta 2A class IIa No references
Homo sapiens tubulin, alpha 1c No references
Homo sapiens tubulin, alpha 3e No references
Homo sapiens tubulin, beta 6 class V No references
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.7 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.5 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 25.8 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 34.0 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.4 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.0 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.1 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 33.2 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 8 class VIII 444 aa 438 aa 33.8 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.2 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 4B class IVb 445 aa 438 aa 32.9 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.7 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.6 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 6 class V 446 aa 438 aa 32.4 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 30.1 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 1 class VI 451 aa 438 aa 32.2 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 33.1 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.4 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 34.2 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.8 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.7 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.6 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.6 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.4 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Babesia bovis tubulin, putative Tubulin   445 aa 459 aa 21.1 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.4 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.1 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.5 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.6 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.4 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.3 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.0958 0.3038
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium falciparum serine repeat antigen 9 0.0079 0.0089 0.0397
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0092 0.0213 0.0676
Echinococcus granulosus tubulin subunit beta 0.029 0.2188 0.2188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.1364 0.4325
Trypanosoma cruzi major cysteine proteinase, putative 0.0079 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0079 0.0089 0.0397
Plasmodium vivax tubulin alpha chain, putative 0.0232 0.1611 0.7214
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0167 0.0958 0.0958
Trichomonas vaginalis tubulin, putative 0.0092 0.0213 0.0676
Onchocerca volvulus 0.0294 0.2233 1
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Brugia malayi beta-tubulin, identical 0.029 0.2188 0.2188
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Schistosoma mansoni alpha tubulin 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Onchocerca volvulus 0.0207 0.1364 0.5946
Toxoplasma gondii cathepsin CPC1 0.0079 0.0089 0.0281
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma brucei cysteine peptidase C (CPC) 0.0387 0.3154 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Loa Loa (eye worm) tubulin beta-4 chain 0.029 0.2188 0.2188
Plasmodium falciparum alpha tubulin 1 0.0232 0.1611 0.7214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Leishmania major beta tubulin 0.029 0.2188 0.6939
Plasmodium falciparum serine repeat antigen 8 0.0079 0.0089 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin epsilon chain, putative 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0079 0.0089 0.0281
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0079 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma brucei beta tubulin 0.0162 0.0916 0.2906
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Loa Loa (eye worm) tubulin beta-2A chain 0.029 0.2188 0.2188
Plasmodium vivax tubulin alpha chain, putative 0.0232 0.1611 0.7214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Echinococcus granulosus cathepsin L 0.0079 0.0089 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1073 1 1
Loa Loa (eye worm) ctsf protein 0.0294 0.2233 0.2233
Trypanosoma cruzi cysteine protease, putative 0.0167 0.0958 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus granulosus beta tubulin 0.029 0.2188 0.2188
Schistosoma mansoni cathepsin s 0.0087 0.0166 0.0166
Loa Loa (eye worm) tubulin beta chain 0.029 0.2188 0.2188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0387 0.3154 0.3154
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Leishmania major beta tubulin 0.029 0.2188 0.6939
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.0958 0.0958
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Brugia malayi cathepsin F-like cysteine proteinase 0.0079 0.0089 0.0089
Brugia malayi tubulin alpha chain - mouse 0.0232 0.1611 0.1611
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Entamoeba histolytica tubulin alpha-1 chain 0.0232 0.1611 0.7099
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0162 0.0908 0.2879
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.0213 0.0676
Giardia lamblia Alpha-tubulin 0.0232 0.1611 0.5109
Treponema pallidum cell division protein FtsZ 0.007 0 0.5
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.2188 0.6939
Echinococcus granulosus cathepsin b 0.1073 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0294 0.2233 0.2233
Schistosoma mansoni tubulin subunit alpha 0.0232 0.1611 0.1611
Brugia malayi Tubulin gamma chain 0.0162 0.0916 0.0916
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trypanosoma brucei epsilon tubulin 0.0162 0.0916 0.2906
Leishmania major beta tubulin 0.029 0.2188 0.6939
Brugia malayi Cathepsin L-like cysteine proteinase 0.0207 0.1364 0.1364
Onchocerca volvulus Cathepsin F homolog 0.0294 0.2233 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Loa Loa (eye worm) hypothetical protein 0.1073 1 1
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Entamoeba histolytica cysteine proteinase 2 0.0167 0.0958 0.4054
Leishmania major beta tubulin 0.029 0.2188 0.6939
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1073 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0232 0.1611 0.5109
Loa Loa (eye worm) beta-tubulin 0.029 0.2188 0.2188
Plasmodium falciparum tubulin beta chain 0.029 0.2188 0.9798
Echinococcus granulosus cathepsin l cysteine peptidase 0.0294 0.2233 0.2233
Loa Loa (eye worm) cysteine protease 0.0294 0.2233 0.2233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Brugia malayi Cathepsin L-like precursor 0.0087 0.0166 0.0166
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Schistosoma mansoni tubulin subunit alpha 0.0232 0.1611 0.1611
Echinococcus multilocularis tubulin alpha 0.0162 0.0916 0.0916
Trichomonas vaginalis tubulin epsilon chain, putative 0.029 0.2188 0.6939
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.0958 0.0958
Echinococcus multilocularis tubulin subunit TubB 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0079 0.0089 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Echinococcus multilocularis cysteine protease 0.0294 0.2233 0.2233
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0079 0.0089 0.0397
Echinococcus granulosus tubulin gamma 1 chain 0.0162 0.0916 0.0916
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1073 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.0958 0.3038
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.2233 1
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Loa Loa (eye worm) hypothetical protein 0.0162 0.0908 0.0908
Leishmania major cysteine peptidase A (CPA) 0.0294 0.2233 0.7081
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis tubulin epsilon chain, putative 0.0232 0.1611 0.5109
Plasmodium falciparum serine repeat antigen 1 0.0079 0.0089 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0079 0.0089 0.0397
Trichomonas vaginalis tubulin beta chain, putative 0.0092 0.0213 0.0676
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Toxoplasma gondii cathepsin CPL 0.0294 0.2233 0.7081
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Onchocerca volvulus Cathepsin L homolog 0.0294 0.2233 1
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Brugia malayi Tubulin beta-1 chain 0.029 0.2188 0.2188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Echinococcus multilocularis tubulin alpha 1C chain 0.0232 0.1611 0.1611
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Giardia lamblia Cathepsin B precursor 0.0387 0.3154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0294 0.2233 0.7081
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Mycobacterium tuberculosis Cell division protein FtsZ 0.007 0 0.5
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Giardia lamblia Beta tubulin 0.029 0.2188 0.6939
Schistosoma mansoni tubulin subunit alpha 0.0232 0.1611 0.1611
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.0213 0.0676
Onchocerca volvulus 0.0294 0.2233 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Echinococcus multilocularis Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Echinococcus granulosus tubulin subunit TubB 0.0232 0.1611 0.1611
Trypanosoma cruzi cruzipain precursor, putative 0.0294 0.2233 0.2233
Echinococcus multilocularis cysteine protease 0.0294 0.2233 0.2233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Loa Loa (eye worm) hypothetical protein 0.0294 0.2233 0.2233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Loa Loa (eye worm) hypothetical protein 0.0207 0.1364 0.1364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Trypanosoma brucei epsilon tubulin 0.0162 0.0916 0.2906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.0958 0.3038
Trichomonas vaginalis tubulin, putative 0.029 0.2188 0.6939
Echinococcus multilocularis cathepsin L 0.0079 0.0089 0.0089
Trichomonas vaginalis tubulin alpha chain, putative 0.029 0.2188 0.6939
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Echinococcus multilocularis cathepsin L cysteine protease 0.0294 0.2233 0.2233
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Brugia malayi Tubulin alpha-2 chain 0.0232 0.1611 0.1611
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Plasmodium vivax tubulin epsilon chain, putative 0.0162 0.0916 0.4103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.0958 0.3038
Trichomonas vaginalis tubulin gamma chain, putative 0.0162 0.0916 0.2906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.1364 0.4325
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Leishmania major beta tubulin 0.029 0.2188 0.6939
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0294 0.2233 0.2233
Loa Loa (eye worm) alpha-tubulin 0.0232 0.1611 0.1611
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Trichomonas vaginalis tubulin gamma chain, putative 0.0162 0.0916 0.2906
Brugia malayi cathepsin Z-like cysteine proteinase 0.0079 0.0089 0.0089
Brugia malayi cathepsin L-like precursor 0.0207 0.1364 0.1364
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Echinococcus granulosus tubulin beta 4A class IVa 0.029 0.2188 0.2188
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0079 0.0089 0.0089
Leishmania major beta tubulin 0.029 0.2188 0.6939
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Brugia malayi Tubulin beta chain 0.0092 0.0213 0.0213
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0079 0.0089 0.0281
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Toxoplasma gondii alpha tubulin TUBA1 0.0232 0.1611 0.5109
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Brugia malayi cathepsin L precursor 0.0079 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0294 0.2233 0.2233
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0387 0.3154 0.3154
Giardia lamblia Encystation-specific protease 0.0079 0.0089 0.0281
Entamoeba histolytica cysteine protease, putative 0.0294 0.2233 1
Leishmania major beta tubulin 0.029 0.2188 0.6939
Echinococcus multilocularis beta tubulin 0.029 0.2188 0.2188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis tubulin epsilon chain 0.0162 0.0916 0.0916
Schistosoma mansoni tubulin subunit gamma 0.0162 0.0916 0.0916
Echinococcus granulosus alpha tubulin 0.0232 0.1611 0.1611
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0079 0.0089 0.0397
Giardia lamblia Alpha-tubulin 0.0232 0.1611 0.5109
Entamoeba histolytica tubulin alpha chain, putative 0.0232 0.1611 0.7099
Leishmania major beta tubulin 0.029 0.2188 0.6939
Entamoeba histolytica tubulin family protein 0.029 0.2188 0.979
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0079 0.0089 0.0089
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0087 0.0166 0.0166
Schistosoma mansoni alpha tubulin 0.0232 0.1611 0.1611
Brugia malayi Cathepsin L-like precursor 0.0207 0.1364 0.1364
Plasmodium falciparum serine repeat antigen 4 0.0079 0.0089 0.0397
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0089 0.0281
Loa Loa (eye worm) hypothetical protein 0.0207 0.1364 0.1364
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0079 0.0089 0.0089
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Mycobacterium leprae cell division protein FtsZ 0.007 0 0.5
Giardia lamblia Beta tubulin 0.029 0.2188 0.6939
Brugia malayi cathepsin Z-like cysteine proteinase 0.0079 0.0089 0.0089
Loa Loa (eye worm) tubulin alpha 2 0.0162 0.0908 0.0908
Plasmodium vivax vivapain-3 0.0167 0.0958 0.429
Plasmodium falciparum tubulin epsilon chain, putative 0.0162 0.0916 0.4103
Echinococcus multilocularis cathepsin b 0.1073 1 1
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin F (C01 family) 0.0294 0.2233 0.2233
Onchocerca volvulus Cathepsin L homolog 0.0294 0.2233 1
Echinococcus granulosus cathepsin b 0.1073 1 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.1611 0.1611
Leishmania major beta tubulin 0.029 0.2188 0.6939
Giardia lamblia Hypothetical protein 0.0079 0.0089 0.0281
Leishmania major beta tubulin 0.029 0.2188 0.6939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Brugia malayi alpha-tubulin 0.0232 0.1611 0.1611
Plasmodium vivax tubulin gamma chain, putative 0.0162 0.0916 0.4103
Echinococcus multilocularis peroxisome assembly protein 26 0.0232 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Loa Loa (eye worm) alpha-tubulin 0.0232 0.1611 0.1611
Plasmodium vivax unspecified product 0.0087 0.0166 0.0744
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.2233 1
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Onchocerca volvulus 0.0294 0.2233 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0387 0.3154 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Entamoeba histolytica tubulin family protein 0.029 0.2188 0.979
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0079 0.0089 0.0397
Echinococcus granulosus beta tubulin 0.029 0.2188 0.2188
Loa Loa (eye worm) tubulin alpha-2 chain 0.0232 0.1611 0.1611
Onchocerca volvulus 0.0294 0.2233 1
Toxoplasma gondii beta tubulin 0.029 0.2188 0.6939
Trypanosoma brucei tubulin gamma chain 0.0162 0.0916 0.2906
Toxoplasma gondii cathepsin B 0.0387 0.3154 1
Echinococcus multilocularis tubulin beta 1 chain 0.029 0.2188 0.2188
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0958 0.0958
Brugia malayi cathepsin L-like cysteine proteinase 0.0079 0.0089 0.0089
Leishmania major beta tubulin 0.029 0.2188 0.6939
Loa Loa (eye worm) hypothetical protein 0.0087 0.0166 0.0166
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0079 0.0089 0.0397
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0089 0.0281
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0079 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0079 0.0089 0.0281
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Echinococcus multilocularis beta tubulin 0.029 0.2188 0.2188
Onchocerca volvulus 0.0092 0.0213 0.0581
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Plasmodium vivax serine-repeat antigen (SERA) 0.0079 0.0089 0.0397
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Trypanosoma cruzi beta tubulin, putative 0.029 0.2188 0.2188
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.0958 0.0958
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Leishmania major beta tubulin 0.029 0.2188 0.6939
Brugia malayi Cathepsin L-like precursor 0.0207 0.1364 0.1364
Echinococcus multilocularis Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium falciparum serine repeat antigen 6 0.0079 0.0089 0.0397
Giardia lamblia Gamma tubulin 0.0162 0.0916 0.2906
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0162 0.0916 0.2906
Schistosoma mansoni tubulin subunit epsilon 0.0162 0.0916 0.0916
Onchocerca volvulus 0.0294 0.2233 1
Schistosoma mansoni cathepsin S (C01 family) 0.0079 0.0089 0.0089
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0166 0.0166
Echinococcus multilocularis Tubulin beta 2C chain 0.029 0.2188 0.2188
Loa Loa (eye worm) hypothetical protein 0.0087 0.0166 0.0166
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Toxoplasma gondii alpha-tubulin I, putative 0.0232 0.1611 0.5109
Echinococcus granulosus tubulin epsilon chain 0.0162 0.0916 0.0916
Leishmania major beta tubulin 0.029 0.2188 0.6939
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.0958 0.0958
Trypanosoma cruzi major cysteine proteinase, putative 0.0079 0.0089 0.0089
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Echinococcus granulosus cathepsin l1 0.0294 0.2233 0.2233
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Plasmodium falciparum tubulin gamma chain 0.0162 0.0916 0.4103
Echinococcus granulosus tubulin alpha 0.0162 0.0916 0.0916
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Echinococcus granulosus Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Echinococcus granulosus Tubulin beta 2C chain 0.029 0.2188 0.2188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Loa Loa (eye worm) cathepsin B 0.0387 0.3154 0.3154
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.0213 0.0676
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0089 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Leishmania major epsilon tubulin, putative 0.0162 0.0916 0.2906
Trypanosoma brucei epsilon tubulin 0.0162 0.0916 0.2906
Leishmania major beta tubulin 0.029 0.2188 0.6939
Plasmodium vivax unspecified product 0.0079 0.0089 0.0397
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Leishmania major gamma-tubulin 0.0162 0.0916 0.2906
Plasmodium falciparum serine repeat antigen 2 0.0079 0.0089 0.0397
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0162 0.0908 0.0908
Entamoeba histolytica tubulin gamma chain 0.0162 0.0916 0.3859
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1073 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis cathepsin L cysteine protease 0.0294 0.2233 0.2233
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trypanosoma brucei alpha tubulin, putative 0.0092 0.0213 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Mycobacterium ulcerans cell division protein FtsZ 0.007 0 0.5
Echinococcus granulosus peroxisome assembly protein 26 0.0232 0.1611 0.1611
Plasmodium falciparum serine repeat antigen 5 0.0079 0.0089 0.0397
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Echinococcus granulosus tubulin alpha 1C chain 0.0232 0.1611 0.1611
Schistosoma mansoni alpha tubulin 0.0232 0.1611 0.1611
Echinococcus multilocularis tubulin alpha 3 chain 0.0232 0.1611 0.1611
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin F (C01 family) 0.0207 0.1364 0.1364
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Plasmodium vivax vivapain-1 0.0167 0.0958 0.429
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0207 0.1364 0.1364
Trypanosoma cruzi alpha tubulin, putative 0.0232 0.1611 0.1611
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Schistosoma mansoni tubulin subunit beta 0.029 0.2188 0.2188
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0294 0.2233 1
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0166 0.0166
Echinococcus granulosus Tubulin alpha 1 chain 0.0232 0.1611 0.1611
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0294 0.2233 1
Schistosoma mansoni cathepsin B (C01 family) 0.0079 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0294 0.2233 0.7081
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0079 0.0089 0.0397
Trypanosoma cruzi epsilon tubulin, putative 0.0162 0.0916 0.0916
Schistosoma mansoni cathepsin C 0.0079 0.0089 0.0089
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.0089 0.0089
Giardia lamblia Cathepsin B precursor 0.0079 0.0089 0.0281
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0079 0.0089 0.0397
Loa Loa (eye worm) hypothetical protein 0.014 0.0695 0.0695
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Leishmania major beta tubulin 0.029 0.2188 0.6939
Echinococcus granulosus tubulin beta 1 chain 0.029 0.2188 0.2188
Toxoplasma gondii cathepsin CPC2 0.0079 0.0089 0.0281
Echinococcus granulosus tubulin alpha 3 chain 0.0232 0.1611 0.1611
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0079 0.0089 0.0089
Entamoeba histolytica cysteine proteinase, putative 0.0207 0.1364 0.5946
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Loa Loa (eye worm) tubulin alpha 2 0.0162 0.0908 0.0908
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0166 0.0166
Brugia malayi tubulin alpha-2 chain 0.0232 0.1611 0.1611
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Trichomonas vaginalis tubulin alpha chain, putative 0.0162 0.0916 0.2906
Echinococcus multilocularis tubulin, beta 4A class IVa 0.029 0.2188 0.2188
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Echinococcus multilocularis tubulin alpha chain 0.0232 0.1611 0.1611
Echinococcus granulosus cathepsin L 0.0167 0.0958 0.0958
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.014 0.0695 0.2203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0089 0.0281
Echinococcus multilocularis tubulin gamma 1 chain 0.0162 0.0916 0.0916
Giardia lamblia Cathepsin L precursor 0.0079 0.0089 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.0089 0.0281
Schistosoma mansoni cathepsin F (C01 family) 0.0294 0.2233 0.2233
Echinococcus granulosus tubulin alpha 3 chain 0.0232 0.1611 0.1611
Leishmania major beta tubulin 0.029 0.2188 0.6939
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.0958 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.2233 0.7081
Brugia malayi fibroinase precursor 0.0079 0.0089 0.0089
Brugia malayi Cathepsin L-like precursor 0.0294 0.2233 0.2233
Giardia lamblia Hypothetical protein 0.0079 0.0089 0.0281
Plasmodium falciparum alpha tubulin 2 0.0232 0.1611 0.7214
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0294 0.2233 0.2233
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.0958 0.4054
Echinococcus multilocularis hypothetical protein 0.0232 0.1611 0.1611
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Echinococcus granulosus tubulin alpha chain 0.0232 0.1611 0.1611
Loa Loa (eye worm) tubulin alpha-3 chain 0.014 0.0695 0.0695
Leishmania major beta tubulin 0.029 0.2188 0.6939
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.007 0 0.5
Trypanosoma cruzi tubulin gamma chain 0.0162 0.0916 0.0916
Trichomonas vaginalis tubulin, putative 0.0092 0.0213 0.0676
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Plasmodium vivax vivapain-2 0.0294 0.2233 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0232 0.1611 0.1611
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0387 0.3154 1
Loa Loa (eye worm) tubulin alpha chain 0.0232 0.1611 0.1611
Echinococcus multilocularis cathepsin L 0.0167 0.0958 0.0958
Trichomonas vaginalis tubulin beta chain, putative 0.029 0.2188 0.6939
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0089 0.0281
Plasmodium falciparum cysteine proteinase falcipain 1 0.0167 0.0958 0.429
Giardia lamblia Cathepsin B precursor 0.0387 0.3154 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0079 0.0089 0.0397
Trichomonas vaginalis tubulin gamma chain, putative 0.029 0.2188 0.6939
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Echinococcus granulosus cysteine protease 0.0167 0.0958 0.0958
Loa Loa (eye worm) hypothetical protein 0.0207 0.1364 0.1364
Onchocerca volvulus 0.0294 0.2233 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0294 0.2233 0.2233
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.2233 0.2233
Echinococcus multilocularis cathepsin b 0.1073 1 1
Plasmodium vivax unspecified product 0.0167 0.0958 0.429
Plasmodium falciparum serine repeat antigen 7 0.0079 0.0089 0.0397
Trypanosoma brucei alpha tubulin 0.0232 0.1611 0.5109
Loa Loa (eye worm) BEN-1 protein 0.029 0.2188 0.2188
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1073 1 1
Plasmodium falciparum serine repeat antigen 3 0.0079 0.0089 0.0397
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0079 0.0089 0.0397
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0079 0.0089 0.0397
Loa Loa (eye worm) tubulin alpha chain 0.0232 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.2233 0.7081
Echinococcus granulosus cathepsin l1 0.0207 0.1364 0.1364
Echinococcus granulosus tubulin alpha 1C chain 0.0232 0.1611 0.1611
Giardia lamblia Beta tubulin 0.029 0.2188 0.6939
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0089 0.0281
Trypanosoma cruzi epsilon tubulin, putative 0.0162 0.0916 0.0916
Trichomonas vaginalis tubulin beta chain, putative 0.0232 0.1611 0.5109
Toxoplasma gondii beta-tubulin, putative 0.029 0.2188 0.6939
Giardia lamblia Cathepsin B precursor 0.0387 0.3154 1
Loa Loa (eye worm) tubulin beta-1 chain 0.029 0.2188 0.2188
Giardia lamblia Cathepsin L-like protease 0.0079 0.0089 0.0281
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0958 0.0958
Loa Loa (eye worm) fibroinase 0.0294 0.2233 0.2233
Loa Loa (eye worm) tubulin gamma chain 0.0162 0.0916 0.0916
Brugia malayi Tubulin alpha-2 chain 0.0232 0.1611 0.1611
Echinococcus multilocularis tubulin subunit beta 0.029 0.2188 0.2188
Loa Loa (eye worm) BEN-1 protein 0.029 0.2188 0.2188
Toxoplasma gondii preprocathepsin c precursor, putative 0.0079 0.0089 0.0281
Leishmania major alpha tubulin 0.0232 0.1611 0.5109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0089 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.2233 0.7081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0079 0.0089 0.0281
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.0958 0.0958
Giardia lamblia Cysteine protease 0.0079 0.0089 0.0281
Plasmodium falciparum cysteine proteinase falcipain 3 0.0294 0.2233 1
Giardia lamblia Cathepsin L-like protease 0.0079 0.0089 0.0281
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0079 0.0089 0.0397
Echinococcus granulosus cathepsin L cysteine protease 0.0167 0.0958 0.0958
Plasmodium vivax tubulin beta chain, putative 0.029 0.2188 0.9798
Entamoeba histolytica cysteine protease, putative 0.0167 0.0958 0.4054
Leishmania major beta tubulin 0.029 0.2188 0.6939
Leishmania major cathepsin L-like protease 0.0294 0.2233 0.7081
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0089
Plasmodium vivax serine-repeat antigen (SERA) 0.0079 0.0089 0.0397
Plasmodium vivax vivapain-2 0.0294 0.2233 1
Trypanosoma brucei beta tubulin 0.029 0.2188 0.6939
Toxoplasma gondii beta-1 tubulin, putative 0.029 0.2188 0.6939
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.2233 0.2233
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0089 0.0089
Entamoeba histolytica cysteine proteinase 1, putative 0.0167 0.0958 0.4054
Onchocerca volvulus 0.0294 0.2233 1
Brugia malayi Tubulin alpha chain 0.0232 0.1611 0.1611

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) < 0.01 uM Cytotoxicity against human CAKI-1 cells by SRB assay ChEMBL. 26257861
IC50 (binding) = 5.3 Inhibition of tubulin polymerization in Homo sapiens (human) solid tumor cells ChEMBL. No reference
IC50 (functional) = 23.5 nM Growth inhibition of colon 26 adenocarcinoma cells by 50 %. ChEMBL. 9685242
IC50 (functional) = 23.5 nM Growth inhibition of colon 26 adenocarcinoma cells by 50 %. ChEMBL. 9685242
IC50 (binding) = 5 uM Inhibitory activity against tubulin polymerization ChEMBL. 9685242
IC50 (binding) = 5 uM Inhibitory activity against tubulin polymerization ChEMBL. 9685242

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 9685242

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.