TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 393.446 | Formula: C19H23N9O
H donors: 4 H acceptors: 5 LogP: 2.2 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H]1CCCC[C@H]1Nc1ncc(c(n1)Nc1cccc(c1)n1nccn1)C(=O)N
InChi: 1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1
InChiKey: TXGKRVFSSHPBAJ-JKSUJKDBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	zeta-chain (TCR) associated protein kinase 70kDa	Starlite/ChEMBL	References
Homo sapiens	FGR proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	spleen tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase kinase kinase 9	Starlite/ChEMBL	No references
Homo sapiens	p21 protein (Cdc42/Rac)-activated kinase 7	Starlite/ChEMBL	No references
Homo sapiens	LYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	YES proto-oncogene 1, Src family tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	Janus kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	Get druggable targets OG5_128497	All targets in OG5_128497
Echinococcus granulosus	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	Get druggable targets OG5_128497	All targets in OG5_128497
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05855 spleen tyrosine kinase, putative	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	Get druggable targets OG5_131977	All targets in OG5_131977
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma japonicum	ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128497	All targets in OG5_128497
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	serine/threonine-protein kinase PAK 7	Get druggable targets OG5_131977	All targets in OG5_131977
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	run and tbc1 domain containing	0.0022	0.0069	0.0069
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0041	0.0411	0.1095
Loa Loa (eye worm)	thyroid receptor interactor	0.0022	0.0069	0.017
Echinococcus multilocularis	endophilin A3	0.0022	0.0069	0.0069
Echinococcus granulosus	c src tyrosine kinase	0.0076	0.1055	0.1055
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0069	0.1461
Entamoeba histolytica	unconventional myosin IB	0.0022	0.0069	0.0333
Schistosoma mansoni	cell polarity protein	0.0022	0.0069	0.0069
Echinococcus granulosus	tyrosine protein kinase HCK	0.0119	0.1831	0.1831
Entamoeba histolytica	protein kinase, putative	0.0042	0.0429	0.2304
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0651	0.1746
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0063	0.0815	0.0815
Brugia malayi	SH2 domain containing protein	0.0041	0.0411	0.1095
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0069	0.1461
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0019	0.0007	0.0007
Brugia malayi	SH2 domain containing protein	0.0054	0.0651	0.1746
Trypanosoma brucei	conserved protein	0.0022	0.0069	0.5
Echinococcus multilocularis	PAK box P21 Rho binding	0.0019	0.0009	0.0009
Schistosoma mansoni	tensin	0.0041	0.0411	0.0411
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0022	0.0069	0.0069
Entamoeba histolytica	hypothetical protein, conserved	0.0022	0.0069	0.0333
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0022	0.0069	0.0069
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0041	0.0411	0.0411
Schistosoma mansoni	hypothetical protein	0.0019	0.0009	0.0009
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0022	0.0069	0.0069
Echinococcus granulosus	tyrosine kinase	0.016	0.2577	0.2577
Schistosoma mansoni	Dab2-interacting protein-like	0.0022	0.0069	0.0069
Giardia lamblia	Kinase, STE STE20	0.002	0.0026	0.5
Onchocerca volvulus		0.0054	0.0651	1
Onchocerca volvulus		0.0041	0.0411	0.587
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Echinococcus multilocularis	protein kinase c epsilon type	0.002	0.0028	0.0028
Loa Loa (eye worm)	p53BP2	0.0022	0.0069	0.017
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0221	0.3699	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.002	0.0039	0.0039
Echinococcus multilocularis	tensin	0.0041	0.0411	0.0411
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0022	0.0069	0.0069
Echinococcus granulosus	protein kinase c epsilon type	0.002	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0041	0.0411	0.0411
Trichomonas vaginalis	STE family protein kinase	0.002	0.0026	0.0424
Echinococcus granulosus	twitchin	0.002	0.0024	0.0024
Schistosoma mansoni	sorting nexin	0.0022	0.0069	0.0069
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0182	0.2981	0.2981
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0019	0.0007	0.0007
Trichomonas vaginalis	p67phox protein, putative	0.0022	0.0069	0.1461
Entamoeba histolytica	protein kinase, putative	0.0119	0.1831	1
Echinococcus granulosus	tyrosine kinase	0.0054	0.0651	0.0651
Brugia malayi	Tyrosine-protein kinase abl-1	0.0076	0.1055	0.2841
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0182	0.2981	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0019	0.0009	0.0005
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0182	0.2981	0.2981
Brugia malayi	Src substrate cortactin	0.0022	0.0069	0.017
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0069	0.017
Echinococcus multilocularis	N chimaerin	0.0048	0.0544	0.0544
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0063	0.0815	0.2189
Schistosoma mansoni	shc transforming protein	0.0041	0.0411	0.0411
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0039	0.0039
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.002	0.0026	0.0026
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.002	0.0026	0.0026
Schistosoma mansoni	protein kinase	0.0019	0.0009	0.0009
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0041	0.0411	0.0411
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0041	0.0411	0.1095
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0019	0.0009	0.0009
Echinococcus multilocularis	Immunoglobulin	0.0019	0.0007	0.0007
Schistosoma mansoni	SH2A	0.0041	0.0411	0.0411
Schistosoma mansoni	signal transduction protein lnk-related	0.0041	0.0411	0.0411
Brugia malayi	Myosin tail family protein	0.0022	0.0069	0.017
Schistosoma mansoni	hypothetical protein	0.0019	0.0009	0.0009
Loa Loa (eye worm)	SH2 domain-containing protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	SH2 motif	0.0041	0.0411	0.0411
Brugia malayi	RhoGAP domain containing protein	0.0048	0.0544	0.1456
Echinococcus multilocularis	transfer RNA-Ala	0.0022	0.0069	0.0069
Onchocerca volvulus		0.0041	0.0411	0.587
Loa Loa (eye worm)	SH2 domain-containing protein	0.0041	0.0411	0.1095
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0022	0.0069	0.0069
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0552	0.0552
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0041	0.0411	0.0411
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0477	0.0477
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0042	0.0439	0.117
Entamoeba histolytica	protein kinase, putative	0.002	0.0026	0.0097
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0182	0.2981	0.2981
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0041	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Echinococcus granulosus	roundabout 2	0.0019	0.0007	0.0007
Brugia malayi	Variant SH3 domain containing protein	0.0048	0.0544	0.1456
Schistosoma mansoni	formin binding protein and related proteins	0.0022	0.0069	0.0069
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0022	0.0069	0.0069
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Onchocerca volvulus		0.0041	0.0411	0.587
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Schistosoma mansoni	growth factor receptor-bound protein	0.0066	0.0873	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0069	0.017
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0651	0.1746
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0022	0.0069	0.017
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0076	0.1055	0.1055
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0022	0.0069	0.0069
Echinococcus multilocularis	tyrosine protein kinase Blk	0.016	0.2577	0.2577
Echinococcus multilocularis	PAK box P21 Rho binding	0.002	0.0026	0.0026
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0041	0.0411	0.587
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0651	0.1746
Schistosoma mansoni	dreadlocks/dock	0.0022	0.0069	0.0069
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0054	0.0651	0.0651
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0182	0.2981	0.2981
Echinococcus granulosus	SHC transforming protein 3	0.0041	0.0411	0.0411
Schistosoma mansoni	hypothetical protein	0.0041	0.0411	0.0411
Schistosoma mansoni	vesicular amine transporter	0.0022	0.006	0.006
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0041	0.0411	0.0411
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0041	0.0411	0.0411
Echinococcus granulosus	SH2 domain containing protein 7	0.0041	0.0411	0.0411
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0048	0.0544	0.0544
Schistosoma mansoni	protein kinase	0.002	0.0026	0.0026
Schistosoma mansoni	tyrosine kinase	0.0182	0.2981	0.2981
Echinococcus granulosus	defective proboscis extension response	0.0019	0.0007	0.0007
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0054	0.0651	0.0651
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0182	0.2981	0.2981
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0022	0.0069	0.0069
Echinococcus granulosus	tyrosine protein kinase Src42A	0.015	0.2395	0.2395
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0651	0.1746
Loa Loa (eye worm)	TK protein kinase	0.0119	0.1831	0.4942
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0182	0.2981	0.2981
Brugia malayi	Peripheral plasma membrane protein CASK	0.0022	0.0069	0.017
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0022	0.0069	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Echinococcus granulosus	RNA directed DNA polymerase	0.0048	0.0533	0.0533
Echinococcus granulosus	expressed protein	0.0022	0.0069	0.0069
Brugia malayi	serine/threonine-protein kinase PAK 7	0.0221	0.3699	1
Brugia malayi	protein-tyrosine kinase	0.0022	0.0069	0.017
Schistosoma mansoni	tyrosine kinase	0.0526	0.9254	0.9254
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0424	1
Trichomonas vaginalis	STE family protein kinase	0.002	0.0026	0.0424
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0041	0.0411	0.0411
Schistosoma mansoni	suppressor of cytokine signaling	0.0041	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Echinococcus multilocularis	roundabout 2	0.0019	0.0007	0.0007
Entamoeba histolytica	protein kinase, putative	0.002	0.0026	0.0097
Echinococcus multilocularis		0.0041	0.0411	0.0411
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0048	0.0544	0.1456
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Brugia malayi	SH2 domain containing protein	0.0041	0.0411	0.1095
Schistosoma mansoni	tyrosine kinase	0.0182	0.2981	0.2981
Echinococcus granulosus	signal transduction protein lnk realted	0.0041	0.0411	0.0411
Schistosoma mansoni	tyrosine kinase	0.0076	0.1055	0.1055
Entamoeba histolytica	p21-activated kinase	0.002	0.0026	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0022	0.0069	0.0333
Schistosoma mansoni	tyrosine kinase	0.0032	0.0249	0.0249
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0896	0.0896
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.016	0.2577	0.2577
Schistosoma mansoni	growth factor receptor-bound protein	0.0063	0.0815	0.0815
Schistosoma mansoni	C-fyn	0.0022	0.0069	0.0069
Echinococcus granulosus	tyrosine protein kinase Srms	0.0054	0.0651	0.0651
Schistosoma mansoni	apoptosis stimulating of P53	0.0022	0.0069	0.0069
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0028	0.0028
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0069	0.017
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0127	1
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Loa Loa (eye worm)	TK protein kinase	0.016	0.2577	0.6962
Brugia malayi	WH1 domain containing protein	0.0019	0.0009	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0182	0.2981	0.2981
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0048	0.0544	0.0544
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.002	0.0026	0.0026
Schistosoma mansoni	tensin-related	0.0041	0.0411	0.0411
Entamoeba histolytica	hypothetical protein, conserved	0.0022	0.0069	0.0333
Echinococcus granulosus	raf serine:threonine protein kinase	0.002	0.0039	0.0039
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0019	0.0009	0.0009
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0041	0.0411	0.0411
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Schistosoma mansoni	protein kinase	0.002	0.0026	0.0026
Echinococcus granulosus	SH2 motif	0.0041	0.0411	0.0411
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0048	0.0533	0.0533
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	c src tyrosine kinase	0.0076	0.1055	0.1055
Echinococcus multilocularis	tyrosine kinase	0.0054	0.0651	0.0651
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0022	0.0069	0.017
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0815	0.2189
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0182	0.2981	0.2981
Schistosoma mansoni	tensin-related	0.0041	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0039	0.037	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Brugia malayi	Variant SH3 domain containing protein	0.0025	0.0127	0.0327
Echinococcus granulosus	PAK box P21 Rho binding	0.0019	0.0009	0.0009
Echinococcus multilocularis	SH2 motif	0.0041	0.0411	0.0411
Loa Loa (eye worm)	guanylate kinase	0.0022	0.0069	0.017
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.0815	0.2189
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0069	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0202	0.3356	0.3356
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.002	0.0026	0.0026
Schistosoma mansoni	tyrosine kinase	0.0057	0.071	0.071
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0651	0.1746
Echinococcus multilocularis	Immunoglobulin	0.0019	0.0007	0.0007
Echinococcus granulosus	src region	0.0022	0.0069	0.0069
Loa Loa (eye worm)	protein-tyrosine kinase	0.0022	0.0069	0.017
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0068	0.0896	0.0896
Schistosoma mansoni	suppressor of cytokine signaling	0.0041	0.0411	0.0411
Echinococcus granulosus	endophilin A3	0.0022	0.0069	0.0069
Brugia malayi	SH2 domain containing protein	0.0054	0.0651	0.1746
Brugia malayi	Protein kinase domain	0.002	0.0026	0.0053
Entamoeba histolytica	SH2 domain containing protein	0.0041	0.0411	0.2208
Schistosoma mansoni	serine/threonine protein kinase	0.0162	0.2624	0.2624
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0032	0.0247	0.0651
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0202	0.3356	0.3356
Echinococcus granulosus	growth factor receptor bound protein 2	0.0066	0.0873	0.0873
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0477	0.1275
Echinococcus multilocularis	SH2 domain containing protein 7	0.0041	0.0411	0.0411
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0041	0.0411	0.587
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0009	0.0005
Schistosoma mansoni	nck2/grb4	0.0063	0.0815	0.0815
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0182	0.2981	0.2981
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0032	0.0247	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0533	0.1426
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0022	0.0069	0.017
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0182	0.2981	0.2981
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0041	0.0411	0.0411
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0041	0.0411	0.1095
Echinococcus granulosus	Immunoglobulin	0.0019	0.0007	0.0007
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0041	0.0411	0.0411
Onchocerca volvulus		0.0023	0.0087	0.0302
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0022	0.0069	0.0069
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0041	0.0411	0.0411
Entamoeba histolytica	protein kinase, putative	0.002	0.0026	0.0097
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0896	0.0896
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0127	1
Schistosoma mansoni	sorbin	0.0022	0.0069	0.0069
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0041	0.0411	0.0411
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0022	0.0069	0.0333
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Entamoeba histolytica	protein kinase, putative	0.0022	0.0069	0.0333
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0424	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0183	0.2999	0.2999
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0054	0.0651	0.0651
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0041	0.0411	0.0411
Loa Loa (eye worm)	SRC-1	0.0182	0.2981	0.8056
Onchocerca volvulus		0.0041	0.0411	0.587
Echinococcus multilocularis	neuroglian	0.0019	0.0007	0.0007
Brugia malayi	Sex muscle abnormal protein 5	0.0063	0.0815	0.2189
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0048	0.0544	0.0544
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0022	0.0069	0.0069
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0022	0.0069	0.0069
Onchocerca volvulus		0.0041	0.0411	0.587
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0552	0.0552
Echinococcus granulosus	SH2 motif	0.0041	0.0411	0.0411
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Schistosoma mansoni	dynamin-associated protein	0.0025	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	NCK adaptor protein	0.0066	0.0873	0.0873
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.002	0.0026	0.0026
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0069	0.017
Brugia malayi	hypothetical protein	0.0054	0.0651	0.1746
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0076	0.1055	0.1055
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0182	0.2981	0.2981
Echinococcus multilocularis	expressed protein	0.0022	0.0069	0.0069
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.016	0.2577	0.2577
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0069	0.1461
Echinococcus multilocularis	tyrosine protein kinase Srms	0.016	0.2577	0.2577
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0182	0.2981	0.2981
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0041	0.0411	0.0411
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Schistosoma mansoni	hypothetical protein	0.0022	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0182	0.2981	0.2981
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Loa Loa (eye worm)	STAT protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0022	0.0069	0.0069
Schistosoma mansoni	tyrosine kinase	0.0076	0.1055	0.1055
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0019	0.0009	0.0009
Echinococcus granulosus	protein kinase C gamma type	0.006	0.0763	0.0763
Schistosoma mansoni	GTPase activating protein	0.0041	0.0411	0.0411
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0022	0.0069	0.0069
Onchocerca volvulus		0.0054	0.0651	1
Echinococcus granulosus	neuroglian	0.0019	0.0007	0.0007
Echinococcus multilocularis	Spectrin alpha actinin	0.0022	0.0069	0.0069
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0042	0.0429	0.2304
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Leishmania major	hypothetical protein, conserved	0.0025	0.0127	0.5
Echinococcus granulosus	intersectin 2	0.0027	0.0155	0.0155
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0063	0.0815	0.2189
Brugia malayi	SH2 domain containing protein	0.0041	0.0411	0.1095
Loa Loa (eye worm)	SH2 domain-containing protein	0.0041	0.0411	0.1095
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0069	0.017
Onchocerca volvulus		0.0054	0.0651	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0182	0.2981	0.2981
Onchocerca volvulus		0.0041	0.0411	0.587
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0041	0.0411	0.1095
Schistosoma mansoni	tensin	0.0041	0.0411	0.0411
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0048	0.0544	0.0544
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0041	0.0411	0.0411
Brugia malayi	protein kinase C II.	0.002	0.0028	0.0057
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0182	0.2981	0.2981
Entamoeba histolytica	hypothetical protein	0.0022	0.0069	0.0333
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0019	0.0009	0.0009
Brugia malayi	Tensin	0.0041	0.0411	0.1095
Loa Loa (eye worm)	TK/ABL protein kinase	0.0054	0.0651	0.1746
Echinococcus granulosus	Protein kinase C brain isozyme	0.0068	0.0896	0.0896
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0009	0.0005
Schistosoma mansoni	tyrosine kinase	0.0567	1	1
Echinococcus granulosus	nostrin	0.0022	0.0069	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0069	0.1461
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	tyrosine protein kinase shark	0.0567	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0054	0.0651	0.1746
Brugia malayi	Protein kinase c protein 2	0.0057	0.0712	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	SH2 motif	0.0041	0.0411	0.0411
Onchocerca volvulus		0.0025	0.0127	0.1001
Schistosoma mansoni	eps8-related protein	0.0022	0.0069	0.0069
Echinococcus multilocularis	nostrin	0.0022	0.0069	0.0069
Schistosoma mansoni	nephrin	0.0019	0.0007	0.0007
Echinococcus multilocularis	signal transduction protein lnk realted	0.0041	0.0411	0.0411
Echinococcus multilocularis	SHC transforming protein 3	0.0041	0.0411	0.0411
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0477	0.1275
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0041	0.0411	0.0411
Schistosoma mansoni	hypothetical protein	0.0022	0.0069	0.0069
Brugia malayi	Variant SH3 domain containing protein	0.0042	0.0439	0.117
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0022	0.0069	0.0069
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.002	0.0026	0.0026
Entamoeba histolytica	protein kinase, putative	0.002	0.0026	0.0097
Onchocerca volvulus		0.0054	0.0651	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	tensin	0.0041	0.0411	0.0411
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.002	0.0028	0.0057
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0022	0.0069	0.0069
Brugia malayi	SH2 domain containing protein	0.0041	0.0411	0.1095
Brugia malayi	SH2 domain containing protein	0.0041	0.0411	0.1095
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0411	0.1095
Brugia malayi	SH2 domain containing protein	0.0041	0.0411	0.1095
Echinococcus granulosus	N chimaerin	0.0048	0.0544	0.0544
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0477	0.0477
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0069	0.1461
Echinococcus granulosus	hypothetical protein	0.0041	0.0411	0.0411
Brugia malayi	Variant SH3 domain containing protein	0.0022	0.0069	0.017
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0005
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.005	0.0579	0.1549
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0124	0.1934	0.1934
Onchocerca volvulus		0.0054	0.0651	1
Schistosoma mansoni	adapter molecule crk	0.0063	0.0815	0.0815
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0076	0.1055	0.1055
Brugia malayi	SRC-1	0.0182	0.2981	0.8056
Brugia malayi	protein-tyrosine kinase	0.016	0.2577	0.6962
Echinococcus multilocularis	RNA directed DNA polymerase	0.0048	0.0533	0.0533
Schistosoma mansoni	hypothetical protein	0.0019	0.0009	0.0009
Echinococcus granulosus	Spectrin alpha actinin	0.0022	0.0069	0.0069
Schistosoma mansoni	vav2	0.0048	0.0544	0.0544
Trichomonas vaginalis	STE family protein kinase	0.002	0.0026	0.0424
Echinococcus granulosus	tensin	0.0041	0.0411	0.0411
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0054	0.0651	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0127	0.0327
Trichomonas vaginalis	STE family protein kinase	0.002	0.0026	0.0424
Echinococcus multilocularis	intersectin 2	0.0027	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0666	0.1787
Trichomonas vaginalis	STE family protein kinase	0.002	0.0026	0.0424
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0022	0.0069	0.0069
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0022	0.0069	0.0069
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0063	0.0815	0.0815
Brugia malayi	SH2 domain containing protein	0.0041	0.0411	0.1095
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0022	0.0069	0.0069
Schistosoma mansoni	protein kinase	0.002	0.0026	0.0026
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0041	0.0411	0.1095
Echinococcus granulosus	tyrosine protein kinase Blk	0.016	0.2577	0.2577
Brugia malayi	SH3 domain containing protein	0.0022	0.0069	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0069	0.1461
Brugia malayi	hypothetical protein	0.0041	0.0411	0.1095
Onchocerca volvulus		0.0054	0.0651	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0124	0.1934	0.1934
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.015	0.2395	0.2395
Brugia malayi	Guanylate kinase family protein	0.0022	0.0069	0.017
Schistosoma mansoni	tensin	0.0041	0.0411	0.0411
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0076	0.1055	0.1055
Echinococcus granulosus	NCK adaptor protein	0.0063	0.0815	0.0815
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0119	0.1831	0.1831
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0054	0.0651	0.0651
Echinococcus granulosus	expressed conserved protein	0.0041	0.0411	0.0411
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.0815	0.2189
Brugia malayi	Spectrin alpha chain	0.0022	0.0069	0.017
Echinococcus multilocularis	serine threonine protein kinase	0.006	0.0763	0.0763
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0651	0.1746

Activities

Activity type	Activity value	Assay description	Source	Reference
Fu (ADMET)	= 1.4 %	Fraction unbound in human plasma	ChEMBL.	23350847
IC50 (binding)	= 1 nM	Inhibition of human recombinant spleen tyrosine kinase (360 to 635 amino acid residues) after 10 mins by scintillation counting analysis	ChEMBL.	23151054
IC50 (binding)	= 1 nM	Inhibition of human recombinant truncated SYK (360 to 365 amino acid residues) using N-terminally biotinylated EPEGDYEEVLE peptide as substrate assessed as inhibition of [33P]-ATP incorporation incubated for 10 mins prior to substrate addition measured after 15 mins by scintillation counting	ChEMBL.	23350847
IC50 (binding)	= 1 nM	Millipore Kinase Panel Assay	BINDINGDB.	No reference
IC50 (binding)	= 6 nM	BindingDB_Patents: Inhibition Assay. SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). LANCE refers to homogeneous time resolved fluorometry applications using techniques such as time-resolved fluorescence resonance energy transfer assay (TR-FRET) (see generally for procedures in Perkin Elmer Application Note How to Optimize a Tyrosine Kinase Assay Using Time Resolved Fluorescence-Based LANCE Detection, wwww.perkinelmer.com/lifesciences). The assay principle involves detection of a phosphorylated substrate using energy transfer from a phosphospecific europium-labeled antibody to streptavidin-allophycocyanin as an acceptor.To test the ability of candidate molecules to inhibit SYK tyrosine phosphorylation activity, molecules are reconstituted in 30% DMSO and serially diluted 1:3 with the final dilution containing DMSO in the absence of the candidate molecule. The final DMSO concentration in the assay is 3%.	ChEMBL.	No reference
IC50 (binding)	= 6 nM	BindingDB_Patents: Inhibition Assay. SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). LANCE refers to homogeneous time resolved fluorometry applications using techniques such as time-resolved fluorescence resonance energy transfer assay (TR-FRET) (see generally for procedures in Perkin Elmer Application Note How to Optimize a Tyrosine Kinase Assay Using Time Resolved Fluorescence-Based LANCE Detection, wwww.perkinelmer.com/lifesciences). The assay principle involves detection of a phosphorylated substrate using energy transfer from a phosphospecific europium-labeled antibody to streptavidin-allophycocyanin as an acceptor.To test the ability of candidate molecules to inhibit SYK tyrosine phosphorylation activity, molecules are reconstituted in 30% DMSO and serially diluted 1:3 with the final dilution containing DMSO in the absence of the candidate molecule. The final DMSO concentration in the assay is 3%.	ChEMBL.	No reference
IC50 (binding)	= 13 nM	Inhibition of Syk (unknown origin) using 4 uM peptide assessed as product formation after 60 mins incubation by microfluidic mobility shift assay	ChEMBL.	24726806
IC50 (binding)	= 13 nM	Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay	ChEMBL.	25633741
IC50 (binding)	= 13 nM	Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay	ChEMBL.	26320624
IC50 (binding)	= 60 nM	Inhibition of ZAP70 (unknown origin)	ChEMBL.	24726806
IC50 (binding)	= 68 nM	Inhibition of human ZAP70	ChEMBL.	25633741
IC50 (binding)	= 81 nM	Millipore Kinase Panel Assay	BINDINGDB.	No reference
IC50 (binding)	= 90 nM	Inhibition of human PKCalpha	ChEMBL.	25633741
IC50 (binding)	= 123 nM	Millipore Kinase Panel Assay	BINDINGDB.	No reference
IC50 (binding)	= 139 nM	Millipore Kinase Panel Assay	BINDINGDB.	No reference
IC50 (binding)	= 166 nM	BindingDB_Patents: Millipore Kinase Panel Assay. Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were determined for those kinases that were inhibited by >80% at 300 nM in the Millipore kinase panel.	ChEMBL.	No reference
IC50 (binding)	= 178 nM	Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assay	ChEMBL.	24726806
IC50 (binding)	= 178 nM	Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation measured after 15 mins by flow cytometric analysis	ChEMBL.	25633741
IC50 (binding)	= 178 nM	Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation measured after 15 mins by flow cytometric analysis	ChEMBL.	26320624
IC50 (binding)	= 199 nM	Millipore Kinase Panel Assay	BINDINGDB.	No reference
IC50 (binding)	= 238 nM	Inhibition of Lyn (unknown origin)	ChEMBL.	24726806
IC50 (binding)	= 244 nM	Millipore Kinase Panel Assay	BINDINGDB.	No reference
IC50 (binding)	= 300 nM	Millipore Kinase Panel Assay	BINDINGDB.	No reference
IC50 (binding)	= 952 nM	Inhibition of Syk in human whole blood assessed as inhibition of P-SLP76 in CD14+ monocytes by flow cytometry	ChEMBL.	24726806
IC50 (binding)	= 952 nM	Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes assessed as phospho-SLP76 level preincubated for 30 mins followed by anti-CD32 stimulation measured after 5 mins by flow cytometric analysis	ChEMBL.	25633741
IC50 (binding)	= 952 nM	Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mins followed by anti-CD32 stimulation measured after 5 mins by flow cytometric analysis	ChEMBL.	26320624
IC50 (binding)	= 1750 nM	Inhibition of JAK2 (unknown origin)	ChEMBL.	24726806
IC50 (binding)	= 1805 nM	Inhibition of ZAP70 in anti-CD3 stimulated human Jurkat T cells assessed as SLP76 phosphorylation at Y128 preincubated for 30 mins followed by anti-CD3 stimulation measured after 2 mins by FACS analysis	ChEMBL.	25633741
IC50 (binding)	= 8600 nM	Inhibition of human ERG by Q-patch assay	ChEMBL.	24726806
IC50 (binding)	= 8600 nM	Inhibition of human ERG expressed in CHO cells by automated Qpatch clamp assay	ChEMBL.	25633741
IC50 (binding)	= 0.223 uM	Inhibition of SYK in human Ramos cells	ChEMBL.	23350847
IC50 (functional)	= 0.223 uM	Cytotoxicity against human Ramos cells	ChEMBL.	23151054
IC50 (binding)	= 0.54 uM	Inhibition of SYK in human whole blood	ChEMBL.	23350847
IC50 (binding)	= 9.1 uM	Inhibition of human ERG channel	ChEMBL.	23350847
IC50 (binding)	= 10 uM	Inhibition of human ERG by manual patch clamp assay	ChEMBL.	25633741
IC50 (ADMET)	> 25 uM	Inhibition of CYP3A4 (unknown origin)	ChEMBL.	23350847
Inhibition (binding)	= 42 %	Inhibition of human ERG at 10 uM by manual patch clamp assay relative to control	ChEMBL.	25633741
Inhibition (binding)	= 72 %	Inhibition of human ERG at 30 uM by manual patch clamp assay relative to control	ChEMBL.	25633741

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23151054

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2177736

Bibliographic References

5 literature references were collected for this gene.

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Detailed information for compound 1715632