TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 472.928 | Formula: C19H13ClN6O3S2
H donors: 1 H acceptors: 6 LogP: 3.36 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cc(ccc1Oc1ccc(c(c1)Cn1cncn1)Cl)S(=O)(=O)Nc1nccs1
InChi: 1S/C19H13ClN6O3S2/c20-17-3-1-15(7-14(17)10-26-12-22-11-24-26)29-18-4-2-16(8-13(18)9-21)31(27,28)25-19-23-5-6-30-19/h1-8,11-12H,10H2,(H,23,25)
InChiKey: JHNJLRRVYPBXDY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.007	0.016	0.0284
Schistosoma mansoni	sex comb on midleg homolog	0.0777	0.3013	0.3006
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0047	0.0066	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Brugia malayi	AIDA-1b	0.0074	0.0174	0.031
Echinococcus granulosus	remodeling and spacing factor 1	0.0047	0.0066	0.009
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Echinococcus granulosus	TAF3 RNA polymerase II TATA box binding protein	0.0047	0.0066	0.009
Schistosoma mansoni	hypothetical protein	0.0957	0.3739	0.3733
Loa Loa (eye worm)	tnks protein	0.0074	0.0174	0.031
Schistosoma mansoni	myst-related protein	0.0049	0.0073	0.0063
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.004	0.0038	0.1388
Schistosoma mansoni	myst histone acetyltransferase	0.0047	0.0066	0.0055
Echinococcus multilocularis	SAM and MBT domain containing protein	0.1125	0.4419	0.7324
Schistosoma mansoni	PHD zinc finger protein XAP135-related	0.0047	0.0066	0.0055
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.1524	0.603	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.1336	0.5273	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0081	0.0201	0.0315
Echinococcus granulosus	PHD and RING finger domain containing protein 1	0.0047	0.0066	0.009
Loa Loa (eye worm)	hypothetical protein	0.1336	0.5273	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0335	0.123	0.2024
Echinococcus multilocularis	neuropeptide s receptor	0.0473	0.1786	0.2948
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0274	0.0981	0.0972
Schistosoma mansoni	rotamase	0.0037	0.0024	0.0013
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.016	0.7804
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0034	0.0012	0.0001
Brugia malayi	jmjC domain containing protein	0.0402	0.15	0.283
Echinococcus multilocularis	Zinc finger, DBF type	0.0047	0.0066	0.009
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0034	0.0012	0.0001
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.028	0.1007	0.1654
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0274	0.0981	0.0972
Brugia malayi	mbt repeat family protein	0.1336	0.5273	1
Echinococcus granulosus	polyhomeotic proximal chromatin protein	0.0074	0.0174	0.0269
Brugia malayi	PHD-finger family protein	0.0047	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.007	0.016	0.0284
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.004	0.0038	0.1388
Onchocerca volvulus		0.0047	0.0066	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Schistosoma mansoni	hypothetical protein	0.041	0.1534	0.1525
Plasmodium falciparum	histone-lysine N-methyltransferase, H3 lysine-4 specific	0.0047	0.0066	0.2608
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0074	0.0174	0.0269
Loa Loa (eye worm)	hypothetical protein	0.007	0.016	0.0284
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0074	0.0174	0.852
Echinococcus multilocularis	polyhomeotic protein 2	0.0074	0.0174	0.0269
Loa Loa (eye worm)	hypothetical protein	0.007	0.016	0.0284
Schistosoma mansoni	hypothetical protein	0.0074	0.0174	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Toxoplasma gondii	AP2 domain transcription factor AP2VIIa-7	0.0047	0.0066	0.1666
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.004	0.0038	0.1388
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0047	0.0066	0.0055
Brugia malayi	PHD-finger family protein	0.0047	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Schistosoma mansoni	phd finger protein	0.0047	0.0066	0.0055
Schistosoma mansoni	dpf3	0.0047	0.0066	0.0055
Mycobacterium ulcerans	beta-lactamase	0.007	0.016	0.5
Onchocerca volvulus		0.0047	0.0066	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0096	0.2443
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.0066	0.2608
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.004	0.0038	0.1388
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0081	0.0201	0.0191
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0081	0.0201	0.0315
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0089	0.0236	0.0374
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0074	0.0176	0.0273
Echinococcus granulosus	phd finger protein 12	0.0047	0.0066	0.009
Plasmodium vivax	protein kinase, putative	0.0074	0.0174	0.7802
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0024	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.1125	0.4419	0.4413
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.028	0.1007	0.1894
Loa Loa (eye worm)	CHromoDomain protein family member	0.0081	0.0201	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Trypanosoma cruzi	Kinesin-13 5, putative	0.0074	0.0174	1
Onchocerca volvulus		0.0048	0.0068	0.0108
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.028	0.1007	0.1654
Echinococcus granulosus	chromobox protein 2	0.0576	0.2202	0.364
Schistosoma mansoni	hypothetical protein	0.0047	0.0066	0.0055
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0089	0.0236	0.043
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.016	0.7804
Echinococcus multilocularis	histone acetyltransferase myst4	0.0047	0.0066	0.009
Echinococcus granulosus	lysine specific demethylase 5A	0.0274	0.0981	0.1611
Brugia malayi	PHD-finger family protein	0.0047	0.0066	0.0105
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0166	0.0156
Echinococcus multilocularis	chromobox protein 2	0.0576	0.2202	0.364
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0202	1
Echinococcus multilocularis	Sterile alpha motif SAM	0.0074	0.0174	0.0269
Toxoplasma gondii	peptidylprolyl isomerase	0.0036	0.002	0.0511
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.016	0.015
Mycobacterium ulcerans	esterase/lipase LipP	0.007	0.016	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0402	0.15	0.283
Brugia malayi	Bromodomain associated family protein	0.0047	0.0066	0.0105
Schistosoma mansoni	hypothetical protein	0.0047	0.0066	0.0055
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0335	0.123	0.2024
Schistosoma mansoni	bromodomain containing protein	0.0047	0.0066	0.0055
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0074	0.0174	0.0269
Trichomonas vaginalis	inhibitor of growth, putative	0.0047	0.0066	0.2847
Schistosoma mansoni	bromodomain containing protein	0.0047	0.0066	0.0055
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0047	0.0066	0.009
Echinococcus granulosus	beta LACTamase domain containing family member	0.007	0.016	0.0246
Schistosoma mansoni	chromobox protein	0.0034	0.0012	0.0001
Schistosoma mansoni	hepatitis B virus X associated protein hbxa	0.0047	0.0066	0.0055
Brugia malayi	Valyl-tRNA synthetase	0.0034	0.0012	0.0003
Echinococcus multilocularis	polycomb protein SCMH1	0.0777	0.3013	0.4987
Brugia malayi	hypothetical protein	0.0074	0.0174	0.031
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.004	0.0038	0.1388
Loa Loa (eye worm)	RNA binding protein	0.0072	0.0166	0.0296
Brugia malayi	Protein cec-1.	0.0034	0.0012	0.0003
Schistosoma mansoni	hypothetical protein	0.0047	0.0066	0.0055
Onchocerca volvulus		0.007	0.016	0.0282
Brugia malayi	hypothetical protein	0.0074	0.0174	0.031
Schistosoma mansoni	cpg binding protein	0.0076	0.0182	0.0172
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0074	0.0174	0.031
Trichomonas vaginalis	rotamase, putative	0.0037	0.0024	0.0633
Schistosoma mansoni	myelin transcription factor 1 myt1	0.028	0.1007	0.0998
Echinococcus multilocularis	pdz domain containing protein	0.0074	0.0174	0.0269
Schistosoma mansoni	DNAj-like protein	0.0074	0.0174	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Loa Loa (eye worm)	PHD-finger family protein	0.0047	0.0066	0.0105
Echinococcus granulosus	polyhomeotic protein 2	0.0074	0.0174	0.0269
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.0166	0.0296
Schistosoma mansoni	hypothetical protein	0.0034	0.0012	0.0001
Toxoplasma gondii	PHD-finger domain-containing protein	0.0047	0.0066	0.1666
Echinococcus multilocularis	zinc finger protein	0.0047	0.0066	0.009
Echinococcus multilocularis	histone acetyltransferase MYST2	0.028	0.1007	0.1654
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0034	0.0012	0.0001
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0095	0.0258	0.6537
Schistosoma mansoni	cpg binding protein	0.0076	0.0182	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Echinococcus granulosus	uro adherence factor A	0.0047	0.0066	0.009
Schistosoma mansoni	zinc finger protein	0.0047	0.0066	0.0055
Echinococcus multilocularis	tumor protein p63	0.0383	0.1423	0.2345
Brugia malayi	Liprin-alpha 2	0.0074	0.0174	0.031
Trypanosoma cruzi	Ring finger domain/PHD-finger, putative	0.0047	0.0066	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Echinococcus granulosus	zinc finger protein	0.0047	0.0066	0.009
Schistosoma mansoni	voltage-gated potassium channel	0.0097	0.0268	0.0258
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.016	0.9113
Brugia malayi	Bromodomain containing protein	0.0047	0.0066	0.0105
Schistosoma mansoni	sex comb on midleg homolog	0.0777	0.3013	0.3006
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0051	0.0082	0.4409
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.0118
Echinococcus granulosus	SAM and MBT domain containing protein	0.1125	0.4419	0.7324
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Echinococcus granulosus	phd finger protein 10	0.0047	0.0066	0.009
Onchocerca volvulus		0.0074	0.0174	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Entamoeba histolytica	hypothetical protein	0.0049	0.0073	1
Schistosoma mansoni	voltage-gated potassium channel	0.0097	0.0268	0.0258
Schistosoma mansoni	polyhomeotic	0.0074	0.0174	0.0163
Echinococcus multilocularis	dnaJ subfamily B	0.041	0.1534	0.2529
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0074	0.0174	0.0269
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.0166	0.0296
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 24	0.0074	0.0174	1
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Echinococcus multilocularis	liprin alpha 2	0.0074	0.0174	0.0269
Brugia malayi	Associated with TFs and helicases family protein	0.0034	0.0012	0.0003
Brugia malayi	M-phase phosphoprotein, mpp8	0.0034	0.0012	0.0003
Giardia lamblia	Giardia trophozoite antigen GTA-1	0.0074	0.0174	0.5
Brugia malayi	SET domain containing protein	0.0034	0.0014	0.0007
Onchocerca volvulus		0.0056	0.0102	0.0172
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0166	0.0156
Loa Loa (eye worm)	helicase	0.0034	0.0012	0.0003
Toxoplasma gondii	SWI2/SNF2-containing PHD finger protein	0.0047	0.0066	0.1666
Onchocerca volvulus		0.0074	0.0174	0.0308
Plasmodium falciparum	EELM2 domain-containing protein, putative	0.0047	0.0066	0.2608
Schistosoma mansoni	zinc finger protein	0.0047	0.0066	0.0055
Echinococcus multilocularis	beta LACTamase domain containing family member	0.007	0.016	0.0246
Brugia malayi	PHD-finger family protein	0.0047	0.0066	0.0105
Brugia malayi	RNA binding protein	0.0072	0.0166	0.0296
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0073	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0026	0.0745
Brugia malayi	PHD-finger family protein	0.0047	0.0066	0.0105
Onchocerca volvulus		0.0074	0.0174	0.0308
Echinococcus granulosus	histone acetyltransferase myst4	0.0047	0.0066	0.009
Onchocerca volvulus		0.0074	0.0174	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Brugia malayi	Shank2E	0.0074	0.0174	0.031
Schistosoma mansoni	chromobox protein	0.0034	0.0012	0.0001
Schistosoma mansoni	myst-related protein	0.0049	0.0073	0.0063
Echinococcus multilocularis	PHD finger protein 14	0.0047	0.0066	0.009
Echinococcus granulosus	fetal alzheimer antigen falz	0.0047	0.0066	0.009
Trypanosoma cruzi	Ring finger domain/PHD-finger, putative	0.0047	0.0066	0.2971
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0034	0.0012	0.0295
Brugia malayi	hypothetical protein	0.0047	0.0066	0.0105
Giardia lamblia	Kinesin-13	0.0074	0.0174	0.5
Echinococcus granulosus	liprin alpha 2	0.0074	0.0174	0.0269
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0166	0.0156
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0034	0.0012	0.0295
Toxoplasma gondii	PHD-finger domain-containing protein	0.0047	0.0066	0.1666
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0073	0.0118
Trichomonas vaginalis	esterase, putative	0.007	0.016	0.7804
Brugia malayi	hypothetical protein	0.0047	0.0066	0.0105
Onchocerca volvulus		0.0074	0.0174	0.0308
Brugia malayi	Heterochromatin protein 1	0.0034	0.0012	0.0003
Schistosoma mansoni	zinc finger protein	0.0047	0.0066	0.0055
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0085	0.0219	1
Mycobacterium leprae	conserved hypothetical protein	0.007	0.016	0.5
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0034	0.0012	0.0295
Schistosoma mansoni	Protein aveugle	0.0074	0.0174	0.0163
Onchocerca volvulus		0.007	0.016	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0202	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0014	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Echinococcus granulosus	polycomb protein SCMH1	0.0777	0.3013	0.4987
Brugia malayi	Sphingomyelin synthase-related 1	0.0074	0.0174	0.031
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0051	0.0082	0.0117
Plasmodium vivax	SNF2 family N-terminal domain containing protein	0.0047	0.0066	0.2608
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.0957	0.3739	0.6194
Echinococcus granulosus	histone acetyltransferase myst3	0.0121	0.0363	0.0585
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.004	0.0038	0.1388
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0074	0.0174	0.0163
Echinococcus multilocularis	PHD and RING finger domain containing protein 1	0.0047	0.0066	0.009
Schistosoma mansoni	chromobox protein	0.0576	0.2202	0.2194
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0037	0.0026	0.0745
Onchocerca volvulus		0.007	0.016	0.0282
Brugia malayi	SET domain containing protein	0.0048	0.0068	0.011
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0102	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Echinococcus multilocularis	phd finger protein 12	0.0047	0.0066	0.009
Onchocerca volvulus		0.0034	0.0014	0.0005
Schistosoma mansoni	SET domain protein	0.0048	0.0068	0.0058
Schistosoma mansoni	phd finger protein	0.0121	0.0363	0.0353
Plasmodium vivax	hypothetical protein, conserved	0.007	0.016	0.7147
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.016	0.7804
Echinococcus multilocularis	neuropeptide receptor A26	0.0473	0.1786	0.2948
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0037	0.0024	0.0025
Mycobacterium ulcerans	hypothetical protein	0.007	0.016	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0073	0.0118
Brugia malayi	CHD4 protein	0.0081	0.0201	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0166	0.0156
Loa Loa (eye worm)	PHD-finger family protein	0.0047	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Toxoplasma gondii	ABC1 family protein	0.007	0.016	0.4054
Trypanosoma cruzi	Kinesin-13 5, putative	0.0074	0.0174	1
Brugia malayi	cask-interacting protein 2	0.0074	0.0174	0.031
Echinococcus multilocularis	uro adherence factor A	0.0047	0.0066	0.009
Echinococcus multilocularis	phd finger protein 10	0.0047	0.0066	0.009
Echinococcus granulosus	neuropeptide receptor A26	0.0473	0.1786	0.2948
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Onchocerca volvulus		0.0047	0.0066	0.0103
Brugia malayi	TAR-binding protein	0.0072	0.0166	0.0296
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.1524	0.603	1
Echinococcus granulosus	neuropeptide s receptor	0.0473	0.1786	0.2948
Brugia malayi	hypothetical protein	0.0034	0.0012	0.0003
Echinococcus multilocularis	lysine specific demethylase 5A	0.0227	0.0791	0.1295
Loa Loa (eye worm)	hypothetical protein	0.0078	0.019	0.0342
Schistosoma mansoni	fyve-containing	0.0047	0.0066	0.0055
Echinococcus multilocularis	lysine specific demethylase 5B	0.0047	0.0066	0.009
Onchocerca volvulus	Tankyrase homolog	0.0074	0.0174	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.016	0.9113
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.004	0.0038	0.1388
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Loa Loa (eye worm)	MBCTL1	0.028	0.1007	0.1894
Echinococcus granulosus	liprin alpha 2	0.0074	0.0174	0.0269
Schistosoma mansoni	Protein aveugle	0.0074	0.0174	0.0163
Echinococcus granulosus	Sterile alpha motif SAM	0.0074	0.0174	0.0269
Echinococcus granulosus	Zinc finger DBF type	0.0047	0.0066	0.009
Toxoplasma gondii	PHD-finger domain-containing protein	0.0047	0.0066	0.1666
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0174	0.852
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0047	0.0066	0.009
Brugia malayi	F/Y-rich N-terminus family protein	0.0054	0.0095	0.016
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0034	0.0012	0.0003
Schistosoma mansoni	hypothetical protein	0.0074	0.0174	0.0163
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0176	0.0166
Echinococcus multilocularis	cpg binding protein	0.0076	0.0182	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0047	0.0066	0.009
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Brugia malayi	beta-lactamase family protein	0.007	0.016	0.0284
Echinococcus multilocularis	liprin alpha 2	0.0074	0.0174	0.0269
Loa Loa (eye worm)	hypothetical protein	0.007	0.016	0.0284
Echinococcus granulosus	dnaJ subfamily B	0.041	0.1534	0.2529
Echinococcus granulosus	sodium channel protein	0.0051	0.0082	0.0117
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Echinococcus multilocularis	histone acetyltransferase myst3	0.0121	0.0363	0.0585
Brugia malayi	bicaudal-C	0.0074	0.0174	0.031
Mycobacterium leprae	Probable lipase LipE	0.007	0.016	0.5
Trypanosoma brucei	Ring finger domain/PHD-finger, putative	0.0047	0.0066	0.2971
Trichomonas vaginalis	rotamase, putative	0.0036	0.002	0.045
Echinococcus granulosus	cpg binding protein	0.0076	0.0182	0.0283
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0089	0.0236	0.043
Schistosoma mansoni	requim req/dpf2	0.0047	0.0066	0.0055
Schistosoma mansoni	hypothetical protein	0.0047	0.0066	0.0055
Onchocerca volvulus		0.0074	0.0174	0.0308
Echinococcus multilocularis	Sterile alpha motif type	0.0074	0.0174	0.0269
Brugia malayi	jmjC domain containing protein	0.0074	0.0176	0.0315
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.016	0.7804
Loa Loa (eye worm)	hypothetical protein	0.007	0.016	0.0284
Echinococcus granulosus	lysine specific demethylase 5B	0.0047	0.0066	0.009
Echinococcus granulosus	expressed protein	0.0037	0.0024	0.002
Echinococcus multilocularis	expressed protein	0.0037	0.0024	0.002
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.016	0.7804
Loa Loa (eye worm)	heterochromatin protein 1	0.0034	0.0012	0.0003
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0074	0.0174	0.0163
Toxoplasma gondii	hypothetical protein	0.0075	0.0178	0.4509
Brugia malayi	chromobox protein homolog 3	0.0034	0.0012	0.0003
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.007	0.016	0.5
Toxoplasma gondii	PLU-1 family protein	0.0128	0.0394	1
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.0102	0.0092
Plasmodium falciparum	zinc finger protein, putative	0.0049	0.0073	0.295
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.0166	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Schistosoma mansoni	spingomyelin synthetase-related	0.0074	0.0174	0.0163
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0047	0.0066	0.009
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0036	0.002	0.1397
Echinococcus granulosus	tar DNA binding protein	0.0072	0.0166	0.0256
Brugia malayi	Hypothetical C28H8.9 in chromosome III	0.0047	0.0066	0.0105
Loa Loa (eye worm)	AIDA-1b	0.0074	0.0174	0.031
Schistosoma mansoni	chromobox protein	0.0034	0.0012	0.0001
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0074	0.0174	0.0269
Echinococcus multilocularis	TAF3 RNA polymerase II, TATA box binding protein	0.0047	0.0066	0.009
Loa Loa (eye worm)	beta-lactamase	0.007	0.016	0.0284
Loa Loa (eye worm)	hypothetical protein	0.028	0.1007	0.1894
Brugia malayi	beta-lactamase	0.007	0.016	0.0284
Brugia malayi	mbt repeat family protein	0.0808	0.314	0.5948
Trypanosoma cruzi	hypothetical protein	0.0074	0.0174	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.016	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Echinococcus granulosus	Sterile alpha motif type	0.0074	0.0174	0.0269
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0037	0.0024	0.0025
Schistosoma mansoni	hypothetical protein	0.0047	0.0066	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.0166	0.0296
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.007	0.016	0.0284
Trypanosoma brucei	SAM domain (Sterile alpha motif), putative	0.0074	0.0174	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.028	0.1007	0.1654
Echinococcus multilocularis	polyhomeotic proximal chromatin protein	0.0074	0.0174	0.0269
Brugia malayi	coiled-coil like protein 1	0.0074	0.0174	0.031
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.0957	0.3739	0.6194
Onchocerca volvulus		0.0047	0.0066	0.0103
Brugia malayi	PHD-finger family protein	0.0047	0.0066	0.0105
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0166	0.0156
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0074	0.0176	0.0273
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.016	0.9113
Echinococcus multilocularis	sodium channel protein	0.0051	0.0082	0.0117
Leishmania major	hypothetical protein, conserved	0.007	0.016	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.016	0.015
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0066	0.0105
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0089	0.0236	0.0374
Echinococcus granulosus	PHD finger protein 14	0.0047	0.0066	0.009
Echinococcus multilocularis	remodeling and spacing factor 1	0.0047	0.0066	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0066	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0012	0.0003
Trichomonas vaginalis	cgi-62, putative	0.0074	0.0174	0.852
Brugia malayi	beta-lactamase family protein	0.007	0.016	0.0284
Plasmodium vivax	JmjC domain containing protein	0.0085	0.0219	1
Plasmodium falciparum	SNF2 helicase, putative	0.0047	0.0066	0.2608
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0037	0.0024	0.0643
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.004	0.0038	0.1388
Mycobacterium ulcerans	lipase LipD	0.007	0.016	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0123	0.0113
Onchocerca volvulus		0.0882	0.3438	0.6512
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0174	0.031
Loa Loa (eye worm)	F/Y-rich family protein	0.0047	0.0066	0.0105
Loa Loa (eye worm)	mbt repeat family protein	0.0808	0.314	0.5948
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0449	0.1691	1
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0074	0.0174	0.031
Toxoplasma gondii	PHD-finger domain-containing protein	0.0047	0.0066	0.1666
Echinococcus granulosus	pdz domain containing protein	0.0074	0.0174	0.0269
Echinococcus granulosus	tumor protein p63	0.0383	0.1423	0.2345

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.6576	Inhibition of NaV1.7 ion channel (unknown origin)	ChEMBL.	23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2326127

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1729303