TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 562.587 | Formula: C24H21F3N6O3S2
H donors: 1 H acceptors: 5 LogP: 3.92 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1cc(ccc1Oc1cccc(c1)c1cc(nn1CCN(C)C)C(F)(F)F)S(=O)(=O)Nc1nccs1
InChi: 1S/C24H21F3N6O3S2/c1-32(2)9-10-33-20(14-22(30-33)24(25,26)27)16-4-3-5-18(12-16)36-21-7-6-19(13-17(21)15-28)38(34,35)31-23-29-8-11-37-23/h3-8,11-14H,9-10H2,1-2H3,(H,29,31)
InChiKey: NRXBYNUFPLVXJR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AIDA-1b	0.0098	0.0149	0.03
Schistosoma mansoni	polyhomeotic	0.0098	0.0149	0.0149
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.0152	0.025
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0107	0.0174	0.0174
Echinococcus granulosus	sodium channel protein	0.0051	0.0018	0.0029
Echinococcus granulosus	lysine specific demethylase 5B	0.0062	0.0049	0.008
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.1544	0.4193	0.4193
Loa Loa (eye worm)	PHD-finger family protein	0.0062	0.0049	0.0097
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0101	0.6739
Toxoplasma gondii	hypothetical protein	0.01	0.0153	0.4342
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Echinococcus multilocularis	dnaJ subfamily B	0.0412	0.1026	0.1694
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0048	0.0009	0.0569
Echinococcus granulosus	liprin alpha 2	0.0098	0.0149	0.0246
Echinococcus granulosus	lysine specific demethylase 5A	0.0364	0.0892	0.1472
Schistosoma mansoni	chromobox protein	0.0767	0.202	0.202
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0072	0.4844
Onchocerca volvulus		0.0062	0.0049	0.0097
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0098	0.0149	0.0246
Onchocerca volvulus		0.0071	0.0072	0.0145
Toxoplasma gondii	PLU-1 family protein	0.0171	0.0353	1
Brugia malayi	hypothetical protein	0.0062	0.0049	0.0097
Echinococcus multilocularis	chromobox protein 2	0.0767	0.202	0.3332
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0072	0.0145
Plasmodium falciparum	SNF2 helicase, putative	0.0062	0.0049	0.2529
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Onchocerca volvulus		0.0063	0.005	0.0101
Schistosoma mansoni	zinc finger protein	0.0062	0.0049	0.0049
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0072	0.0072
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0446	0.1121	0.185
Loa Loa (eye worm)	AIDA-1b	0.0098	0.0149	0.03
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0062	0.0049	0.008
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0426	0.1066	0.2141
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Schistosoma mansoni	hypothetical protein	0.0062	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0012	0.0023
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0051	0.0018	0.1227
Schistosoma mansoni	cpg binding protein	0.0091	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0098	0.0149	0.03
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.1273	0.3436	0.5669
Echinococcus multilocularis	polycomb protein SCMH1	0.108	0.2897	0.478
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.0072	0.5
Toxoplasma gondii	PHD-finger domain-containing protein	0.0062	0.0049	0.1371
Echinococcus multilocularis	SAM and MBT domain containing protein	0.1544	0.4193	0.6918
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.2211	0.6061	1
Brugia malayi	jmjC domain containing protein	0.0099	0.0152	0.0304
Brugia malayi	mbt repeat family protein	0.1825	0.498	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Brugia malayi	PHD-finger family protein	0.0062	0.0049	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Onchocerca volvulus		0.0071	0.0072	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0426	0.1066	0.2141
Loa Loa (eye worm)	hypothetical protein	0.1825	0.498	1
Echinococcus multilocularis	neuropeptide s receptor	0.0474	0.1201	0.1982
Echinococcus granulosus	histone acetyltransferase MYST2	0.0426	0.1066	0.1759
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0364	0.0892	0.0892
Echinococcus multilocularis	lysine specific demethylase 5A	0.0302	0.0719	0.1186
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0426	0.1066	0.1759
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.1825	0.498	1
Onchocerca volvulus		0.0098	0.0149	0.03
Echinococcus multilocularis	PHD and RING finger domain containing protein 1	0.0062	0.0049	0.008
Toxoplasma gondii	SWI2/SNF2-containing PHD finger protein	0.0062	0.0049	0.1371
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0451	0.1136	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Mycobacterium ulcerans	lipase LipD	0.0071	0.0072	0.5
Echinococcus multilocularis	Sterile alpha motif type	0.0098	0.0149	0.0246
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0072	0.5
Trichomonas vaginalis	inhibitor of growth, putative	0.0062	0.0049	0.3241
Echinococcus multilocularis	Sterile alpha motif SAM	0.0098	0.0149	0.0246
Toxoplasma gondii	AP2 domain transcription factor AP2VIIa-7	0.0062	0.0049	0.1371
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0028	0.0794
Schistosoma mansoni	hypothetical protein	0.0062	0.0049	0.0049
Brugia malayi	Shank2E	0.0098	0.0149	0.03
Brugia malayi	beta-lactamase family protein	0.0071	0.0072	0.0145
Trypanosoma brucei	SAM domain (Sterile alpha motif), putative	0.0098	0.0149	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0051	0.0018	0.0029
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0049	0.0049
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0012	0.0023
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.0049	0.2529
Schistosoma mansoni	fyve-containing	0.0062	0.0049	0.0049
Brugia malayi	PHD-finger family protein	0.0062	0.0049	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Echinococcus multilocularis	phd finger protein 12	0.0062	0.0049	0.008
Echinococcus granulosus	Zinc finger DBF type	0.0062	0.0049	0.008
Trichomonas vaginalis	cgi-62, putative	0.0098	0.0149	1
Onchocerca volvulus		0.0098	0.0149	0.03
Onchocerca volvulus		0.0071	0.0072	0.0145
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.0072	0.0145
Schistosoma mansoni	hypothetical protein	0.0062	0.0049	0.0049
Onchocerca volvulus		0.0098	0.0149	0.03
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0107	0.0174	0.0287
Echinococcus granulosus	neuropeptide receptor A26	0.0474	0.1201	0.1982
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0098	0.0149	0.0246
Echinococcus granulosus	TAF3 RNA polymerase II TATA box binding protein	0.0062	0.0049	0.008
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0048	0.001	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Brugia malayi	bicaudal-C	0.0098	0.0149	0.03
Echinococcus granulosus	Sterile alpha motif SAM	0.0098	0.0149	0.0246
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0045	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0072	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0072	0.0145
Echinococcus multilocularis	Zinc finger, DBF type	0.0062	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Schistosoma mansoni	myst histone acetyltransferase	0.0062	0.0049	0.0049
Schistosoma mansoni	myst-related protein	0.0064	0.0053	0.0053
Echinococcus multilocularis	polyhomeotic protein 2	0.0098	0.0149	0.0246
Loa Loa (eye worm)	PHD-finger family protein	0.0062	0.0049	0.0097
Onchocerca volvulus		0.0098	0.0149	0.03
Giardia lamblia	Kinesin-13	0.0098	0.0149	0.5
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0062	0.0049	0.008
Brugia malayi	Sphingomyelin synthase-related 1	0.0098	0.0149	0.03
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0089	0.0125	0.0206
Schistosoma mansoni	sex comb on midleg homolog	0.108	0.2897	0.2897
Schistosoma mansoni	phd finger protein	0.0062	0.0049	0.0049
Loa Loa (eye worm)	beta-lactamase	0.0071	0.0072	0.0145
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.0149	1
Schistosoma mansoni	voltage-gated potassium channel	0.0097	0.0147	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Schistosoma mansoni	SET domain protein	0.0063	0.005	0.005
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.0101	0.6739
Loa Loa (eye worm)	tnks protein	0.0098	0.0149	0.03
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0426	0.1066	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Echinococcus multilocularis	liprin alpha 2	0.0098	0.0149	0.0246
Brugia malayi	SET domain containing protein	0.0045	0.0002	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0072	0.4844
Plasmodium vivax	SNF2 family N-terminal domain containing protein	0.0062	0.0049	0.2529
Schistosoma mansoni	hypothetical protein	0.0412	0.1026	0.1026
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0051	0.0018	0.1227
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0426	0.1066	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Toxoplasma gondii	PHD-finger domain-containing protein	0.0062	0.0049	0.1371
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0089	0.0125	0.0251
Schistosoma mansoni	spingomyelin synthetase-related	0.0098	0.0149	0.0149
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0098	0.0149	0.0246
Brugia malayi	CHD4 protein	0.0107	0.0174	0.0349
Echinococcus multilocularis	zinc finger protein	0.0062	0.0049	0.008
Echinococcus granulosus	polycomb protein SCMH1	0.108	0.2897	0.478
Echinococcus multilocularis	uro adherence factor A	0.0062	0.0049	0.008
Brugia malayi	PHD-finger family protein	0.0062	0.0049	0.0097
Echinococcus granulosus	SAM and MBT domain containing protein	0.1544	0.4193	0.6918
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0049	0.0049
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0113	0.0191	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0069	0.0069	0.0138
Onchocerca volvulus		0.0062	0.0049	0.0097
Schistosoma mansoni	DNAj-like protein	0.0098	0.0149	0.0149
Echinococcus granulosus	fetal alzheimer antigen falz	0.0062	0.0049	0.008
Echinococcus multilocularis	cpg binding protein	0.0091	0.0129	0.0213
Schistosoma mansoni	hypothetical protein	0.0098	0.0149	0.0149
Trichomonas vaginalis	esterase, putative	0.0071	0.0072	0.4844
Echinococcus granulosus	PHD finger protein 14	0.0062	0.0049	0.008
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0072	0.0072
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0047	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0072	0.0145
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.2211	0.6061	1
Onchocerca volvulus		0.0062	0.0049	0.0097
Brugia malayi	PHD-finger family protein	0.0062	0.0049	0.0097
Brugia malayi	jmjC domain containing protein	0.0535	0.137	0.2751
Echinococcus multilocularis	TAF3 RNA polymerase II, TATA box binding protein	0.0062	0.0049	0.008
Schistosoma mansoni	zinc finger protein	0.0062	0.0049	0.0049
Echinococcus granulosus	histone acetyltransferase myst3	0.016	0.0323	0.0533
Echinococcus granulosus	pdz domain containing protein	0.0098	0.0149	0.0246
Loa Loa (eye worm)	jmjC domain-containing protein	0.0535	0.137	0.2751
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0051	0.0018	0.1227
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0364	0.0892	0.0892
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0012	0.0023
Echinococcus granulosus	liprin alpha 2	0.0098	0.0149	0.0246
Echinococcus granulosus	phd finger protein 10	0.0062	0.0049	0.008
Brugia malayi	cask-interacting protein 2	0.0098	0.0149	0.03
Echinococcus multilocularis	phd finger protein 10	0.0062	0.0049	0.008
Brugia malayi	coiled-coil like protein 1	0.0098	0.0149	0.03
Echinococcus multilocularis	pdz domain containing protein	0.0098	0.0149	0.0246
Schistosoma mansoni	dpf3	0.0062	0.0049	0.0049
Plasmodium vivax	protein kinase, putative	0.0098	0.0149	0.7802
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0098	0.0149	0.0246
Echinococcus multilocularis	PHD finger protein 14	0.0062	0.0049	0.008
Echinococcus granulosus	polyhomeotic proximal chromatin protein	0.0098	0.0149	0.0246
Echinococcus granulosus	PHD and RING finger domain containing protein 1	0.0062	0.0049	0.008
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0098	0.0149	0.03
Brugia malayi	beta-lactamase family protein	0.0071	0.0072	0.0145
Echinococcus granulosus	zinc finger protein	0.0062	0.0049	0.008
Echinococcus granulosus	phd finger protein 12	0.0062	0.0049	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.0097	0.0147	0.0147
Schistosoma mansoni	Protein aveugle	0.0098	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Schistosoma mansoni	hypothetical protein	0.0062	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0051	0.0018	0.1227
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0051	0.0018	0.1227
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.0072	0.5
Onchocerca volvulus		0.0045	0.0002	0.0004
Brugia malayi	PHD-finger family protein	0.0062	0.0049	0.0097
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0098	0.0149	0.0149
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0072	0.4844
Schistosoma mansoni	jumonji domain containing protein	0.0099	0.0152	0.0152
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.0072	0.2371
Onchocerca volvulus		0.0098	0.0149	0.03
Onchocerca volvulus		0.0098	0.0149	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Brugia malayi	SET domain containing protein	0.0063	0.005	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Schistosoma mansoni	Protein aveugle	0.0098	0.0149	0.0149
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0089	0.0125	0.0251
Brugia malayi	PHD-finger family protein	0.0062	0.0049	0.0097
Schistosoma mansoni	hepatitis B virus X associated protein hbxa	0.0062	0.0049	0.0049
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.1273	0.3436	0.5669
Schistosoma mansoni	sex comb on midleg homolog	0.108	0.2897	0.2897
Brugia malayi	Bromodomain associated family protein	0.0062	0.0049	0.0097
Echinococcus granulosus	chromobox protein 2	0.0767	0.202	0.3332
Echinococcus multilocularis	histone acetyltransferase myst3	0.016	0.0323	0.0533
Schistosoma mansoni	cpg binding protein	0.0091	0.0129	0.0129
Schistosoma mansoni	hypothetical protein	0.0062	0.0049	0.0049
Echinococcus granulosus	uro adherence factor A	0.0062	0.0049	0.008
Plasmodium falciparum	zinc finger protein, putative	0.0064	0.0053	0.2786
Plasmodium vivax	JmjC domain containing protein	0.0113	0.0191	1
Onchocerca volvulus		0.0062	0.0049	0.0097
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0072	0.2371
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0072	0.2371
Echinococcus multilocularis	neuropeptide receptor A26	0.0474	0.1201	0.1982
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0049	0.008
Schistosoma mansoni	requim req/dpf2	0.0062	0.0049	0.0049
Giardia lamblia	Giardia trophozoite antigen GTA-1	0.0098	0.0149	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0062	0.0049	0.008
Schistosoma mansoni	hypothetical protein	0.0098	0.0149	0.0149
Brugia malayi	mbt repeat family protein	0.1122	0.3014	0.6053
Toxoplasma gondii	ABC1 family protein	0.0071	0.0072	0.2048
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.001	0.0659
Leishmania major	hypothetical protein, conserved	0.0071	0.0072	1
Echinococcus granulosus	dnaJ subfamily B	0.0412	0.1026	0.1694
Brugia malayi	hypothetical protein	0.0098	0.0149	0.03
Schistosoma mansoni	zinc finger protein	0.0062	0.0049	0.0049
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 24	0.0098	0.0149	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0426	0.1066	0.1759
Brugia malayi	Liprin-alpha 2	0.0098	0.0149	0.03
Mycobacterium ulcerans	beta-lactamase	0.0071	0.0072	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0051	0.0018	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0072	0.0145
Brugia malayi	hypothetical protein	0.0098	0.0149	0.03
Entamoeba histolytica	hypothetical protein	0.0064	0.0053	1
Echinococcus granulosus	cpg binding protein	0.0091	0.0129	0.0213
Schistosoma mansoni	hypothetical protein	0.1273	0.3436	0.3436
Loa Loa (eye worm)	F/Y-rich family protein	0.0062	0.0049	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0049	0.3241
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0072	0.4844
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.0072	0.012
Schistosoma mansoni	myst-related protein	0.0064	0.0053	0.0053
Echinococcus granulosus	remodeling and spacing factor 1	0.0062	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0012	0.0023
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0051	0.0018	0.1227
Loa Loa (eye worm)	CHromoDomain protein family member	0.0107	0.0174	0.0349
Trypanosoma cruzi	Kinesin-13 5, putative	0.0098	0.0149	1
Brugia malayi	Bromodomain containing protein	0.0062	0.0049	0.0097
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0051	0.0018	0.1227
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0072	0.3779
Brugia malayi	Hypothetical C28H8.9 in chromosome III	0.0062	0.0049	0.0097
Onchocerca volvulus		0.122	0.3289	0.6604
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.0152	0.025
Toxoplasma gondii	PHD-finger domain-containing protein	0.0062	0.0049	0.1371
Trypanosoma cruzi	Kinesin-13 5, putative	0.0098	0.0149	1
Loa Loa (eye worm)	MBCTL1	0.0426	0.1066	0.2141
Loa Loa (eye worm)	mbt repeat family protein	0.1122	0.3014	0.6053
Echinococcus multilocularis	sodium channel protein	0.0051	0.0018	0.0029
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0098	0.0149	1
Echinococcus granulosus	neuropeptide s receptor	0.0474	0.1201	0.1982
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0098	0.0149	0.0149
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0126	0.0227	0.6432
Trypanosoma cruzi	hypothetical protein	0.0098	0.0149	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0446	0.1121	0.185
Echinococcus multilocularis	lysine specific demethylase 5B	0.0062	0.0049	0.008
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.0072	0.0145
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0107	0.0174	0.0287
Toxoplasma gondii	PHD-finger domain-containing protein	0.0062	0.0049	0.1371
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0072	0.0145
Echinococcus granulosus	polyhomeotic protein 2	0.0098	0.0149	0.0246
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0089	0.0125	0.0206
Plasmodium falciparum	histone-lysine N-methyltransferase, H3 lysine-4 specific	0.0062	0.0049	0.2529
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0097
Echinococcus multilocularis	liprin alpha 2	0.0098	0.0149	0.0246
Onchocerca volvulus	Tankyrase homolog	0.0098	0.0149	0.03
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.0072	0.012
Brugia malayi	beta-lactamase	0.0071	0.0072	0.0145
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0062	0.0049	0.0049
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0072	0.5
Echinococcus granulosus	Sterile alpha motif type	0.0098	0.0149	0.0246
Echinococcus granulosus	histone acetyltransferase myst4	0.0062	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0093	0.0187
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0072	0.4844
Schistosoma mansoni	PHD zinc finger protein XAP135-related	0.0062	0.0049	0.0049
Plasmodium falciparum	EELM2 domain-containing protein, putative	0.0062	0.0049	0.2529
Echinococcus multilocularis	polyhomeotic proximal chromatin protein	0.0098	0.0149	0.0246
Echinococcus multilocularis	remodeling and spacing factor 1	0.0062	0.0049	0.008
Schistosoma mansoni	phd finger protein	0.016	0.0323	0.0323
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Echinococcus multilocularis	histone acetyltransferase myst4	0.0062	0.0049	0.008
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0149	0.03
Brugia malayi	hypothetical protein	0.0062	0.0049	0.0097
Mycobacterium leprae	Probable lipase LipE	0.0071	0.0072	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.699	Inhibition of NaV1.7 ion channel (unknown origin)	ChEMBL.	23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2323315

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1729304