Detailed information for compound 1736828

Basic information

Technical information
  • TDR Targets ID: 1736828
  • Name: 2-[4-[(3R)-3-methyl-2-oxo-1,3-dihydroindol-5- yl]-1,3-thiazol-2-yl]guanidine
  • MW: 287.34 | Formula: C13H13N5OS
  • H donors: 3 H acceptors: 2 LogP: 1.06 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)Nc1scc(n1)c1ccc2c(c1)[C@@H](C)C(=O)N2
  • InChi: 1S/C13H13N5OS/c1-6-8-4-7(2-3-9(8)16-11(6)19)10-5-20-13(17-10)18-12(14)15/h2-6H,1H3,(H,16,19)(H4,14,15,17,18)/t6-/m1/s1
  • InChiKey: CQUNHLZVPLLHNG-ZCFIWIBFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-[(3R)-3-methyl-2-oxo-indolin-5-yl]thiazol-2-yl]guanidine
  • 2-[4-[(3R)-3-methyl-2-oxo-5-indolinyl]-2-thiazolyl]guanidine
  • 2-[4-[(3R)-2-keto-3-methyl-indolin-5-yl]thiazol-2-yl]guanidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus activated cdc42 kinase 1 0.0211 0.1534 0.1498
Trichomonas vaginalis AGC family protein kinase 0.0047 0.006 0.0042
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.0216 0.0396
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0105 0.0585 0.0545
Trichomonas vaginalis AGC family protein kinase 0.0105 0.0585 0.1237
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0101 0.0544 0.0504
Echinococcus granulosus protein kinase 0.0084 0.0396 0.0356
Entamoeba histolytica cell division protein kinase 2, putative 0.012 0.0714 0.1611
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0235 0.0235
Echinococcus granulosus dual specificity mitogen activated protein 0.0177 0.123 0.1193
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.0216 0.0396
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0198 0.1413 0.1377
Brugia malayi cyclin-dependent kinase 9 0.0069 0.0255 0.0214
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.013 0.0803 0.1735
Trichomonas vaginalis CAMK family protein kinase 0.007 0.027 0.0519
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0143 0.0921 0.0883
Echinococcus granulosus tyrosine protein kinase Blk 0.0087 0.0414 0.0374
Echinococcus granulosus activated cdc42 kinase 1 0.0211 0.1534 0.1498
Brugia malayi intracellular kinase 0.0122 0.0733 0.0694
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0105 0.0585 0.1237
Echinococcus granulosus tyrosine protein kinase HCK 0.0067 0.0243 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0109 0.0109
Echinococcus multilocularis twitchin 0.0054 0.0126 0.0085
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0146 0.0952 0.0914
Echinococcus granulosus twitchin 0.0174 0.1202 0.1165
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0214 0.1561 0.1526
Trypanosoma cruzi casein kinase, putative 0.0061 0.0186 0.0329
Loa Loa (eye worm) hypothetical protein 0.0084 0.039 0.035
Plasmodium falciparum glycogen synthase kinase 3 0.0122 0.0733 0.1574
Echinococcus granulosus roundabout 2 0.0064 0.021 0.0169
Onchocerca volvulus 0.0058 0.016 0.0027
Entamoeba histolytica serine/threonine protein kinase, putative 0.0045 0.0042 0.0094
Entamoeba histolytica PH domain containing protein kinase, putative 0.0109 0.0617 0.1393
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0061 0.0185 0.0326
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.006 0.0019
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0112 0.0639 0.1362
Echinococcus granulosus neuroglian 0.0064 0.021 0.0169
Entamoeba histolytica protein kinase domain containing protein 0.0044 0.0033 0.0075
Echinococcus multilocularis cyclin dependent kinase 1 0.0112 0.0639 0.06
Echinococcus multilocularis Immunoglobulin 0.012 0.0712 0.0673
Trypanosoma cruzi cdc2-related kinase 3 0.0112 0.0639 0.1362
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.102 0.2229
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.013 0.0803 0.1592
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0533 0.443 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0176 0.0135
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Loa Loa (eye worm) hypothetical protein 0.0187 0.1322 0.1286
Schistosoma mansoni tyrosine kinase 0.0141 0.0902 0.0902
Echinococcus granulosus activin receptor type 0.0443 0.3621 0.3594
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0141 0.0902 0.0864
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0501 0.0501
Toxoplasma gondii AGC kinase 0.0105 0.0585 0.1237
Schistosoma mansoni protein kinase 0.0164 0.1111 0.1111
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0083 0.0383 0.0342
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.0723 0.1552
Entamoeba histolytica protein kinase, putative 0.0067 0.0243 0.0547
Brugia malayi Cam kinase protein 1 0.0061 0.0185 0.0144
Echinococcus granulosus raf serine:threonine protein kinase 0.0053 0.0109 0.0068
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0189 0.1338 0.1301
Loa Loa (eye worm) AGC/PKA protein kinase 0.0105 0.0585 0.0545
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0556 0.0556
Echinococcus granulosus cyclin dependent kinase 7 0.0102 0.0556 0.0516
Toxoplasma gondii AGC kinase 0.0047 0.006 0.0042
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0178 0.1233 0.1196
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0064 0.0212 0.0171
Echinococcus multilocularis microtubule associated protein 2 0.0728 0.6189 0.6173
Brugia malayi Protein kinase domain containing protein 0.0056 0.0137 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0255 0.1926 0.1926
Echinococcus granulosus rho-associated protein kinase 1 0.0328 0.2588 0.2557
Plasmodium vivax histone deacetylase 1, putative 0.0064 0.0216 0.0229
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0176 0.0135
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0086 0.0407 0.0367
Brugia malayi Protein kinase domain containing protein 0.0056 0.0137 0.0096
Loa Loa (eye worm) hypothetical protein 0.008 0.0358 0.0317
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0204 0.0204
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0112 0.0639 0.1362
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0112 0.0639 0.1362
Loa Loa (eye worm) hypothetical protein 0.0064 0.0214 0.0173
Echinococcus granulosus cyclin dependent kinase 9 0.0077 0.0329 0.0289
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.022 0.1616 0.1581
Echinococcus granulosus titin 0.0058 0.016 0.0119
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0209 0.1518 0.1482
Echinococcus granulosus Immunoglobulin 0.012 0.0712 0.0673
Echinococcus granulosus casein kinase I alpha 0.0061 0.0186 0.0145
Plasmodium falciparum protein serine/threonine kinase-1 0.0148 0.0968 0.2111
Brugia malayi Protein kinase domain containing protein 0.0976 0.8413 0.8406
Leishmania major casein kinase, putative 0.0061 0.0186 0.0329
Echinococcus multilocularis serine threonine protein kinase 0.0047 0.006 0.0019
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0158 0.0266
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0189 0.1338 0.1301
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0064 0.021 0.0169
Loa Loa (eye worm) hypothetical protein 0.0187 0.1322 0.1286
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0047 0.006 0.0019
Schistosoma mansoni tyrosine kinase 0.0506 0.4191 0.4191
Schistosoma mansoni nephrin 0.0156 0.1044 0.1044
Schistosoma mansoni hypothetical protein 0.0079 0.0351 0.0351
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0221 0.1627 0.1592
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0122 0.0733 0.1574
Brugia malayi hypothetical protein 0.0064 0.0214 0.0173
Echinococcus multilocularis peroxidasin 0.006 0.018 0.0138
Echinococcus granulosus serine:threonine protein kinase 0.0064 0.0212 0.0171
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0176 0.0135
Loa Loa (eye worm) hypothetical protein 0.0067 0.024 0.0199
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0209 0.1515 0.3357
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.006 0.0176 0.0135
Echinococcus granulosus c src tyrosine kinase 0.0069 0.0258 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0117 0.0117
Trichomonas vaginalis AGC family protein kinase 0.0533 0.443 1
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.0746 0.0707
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0096 0.0501 0.0461
Loa Loa (eye worm) TK/EGFR protein kinase 0.1152 1 1
Brugia malayi Protein kinase domain containing protein 0.0056 0.0137 0.0096
Echinococcus granulosus tyrosine protein kinase Fyn 0.01 0.0535 0.0495
Echinococcus multilocularis protein tyrosine kinase 0.0302 0.2356 0.2324
Brugia malayi serine/threonine-protein kinase plk-2 0.0121 0.0723 0.0684
Echinococcus multilocularis hemicentin 1 0.006 0.0176 0.0135
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0148 0.0968 0.2111
Echinococcus granulosus serine:threonine protein kinase N2 0.0047 0.006 0.0019
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0063 0.0204 0.0163
Schistosoma mansoni protein kinase C mu 0.0102 0.055 0.055
Echinococcus multilocularis casein kinase I delta 0.0061 0.0186 0.0145
Echinococcus granulosus protein kinase shaggy 0.0122 0.0733 0.0694
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0061 0.0185 0.0144
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0097 0.0507 0.0467
Schistosoma mansoni protein kinase 0.0533 0.443 0.443
Echinococcus multilocularis hemicentin 1 0.006 0.0176 0.0135
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0146 0.0952 0.0914
Echinococcus multilocularis roundabout 2 0.0064 0.021 0.0169
Trypanosoma cruzi cdc2-related kinase 1 0.0112 0.0639 0.1362
Brugia malayi Protein kinase domain containing protein 0.0083 0.0383 0.0342
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0047 0.006 0.0019
Echinococcus multilocularis 0.0127 0.0776 0.0737
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0264 0.2013 0.198
Loa Loa (eye worm) AUR protein kinase 0.0533 0.443 0.4407
Entamoeba histolytica protein kinase, putative 0.0041 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0104 0.057 0.053
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0723 0.1552
Schistosoma mansoni vam6/vps39 related 0.0079 0.0351 0.0351
Schistosoma mansoni histone deacetylase 0.0064 0.0216 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0533 0.443 1
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0639 0.1362
Loa Loa (eye worm) AGC/NDR protein kinase 0.0047 0.006 0.0019
Schistosoma mansoni histone deacetylase 0.0064 0.0216 0.0216
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0121 0.0723 0.0684
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0085 0.0403 0.0363
Echinococcus granulosus serine:threonine protein kinase TAO1 0.022 0.1616 0.1581
Loa Loa (eye worm) hypothetical protein 0.006 0.0176 0.0135
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1114 0.9661 0.5
Loa Loa (eye worm) hypothetical protein 0.012 0.0716 0.0677
Echinococcus granulosus insulin growth factor 1 receptor beta 0.051 0.4226 0.4201
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0056 0.0137 0.0096
Schistosoma mansoni tyrosine kinase 0.0662 0.5589 0.5589
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0723 0.0723
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0189 0.1338 0.1301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.021 0.0169
Schistosoma mansoni tyrosine kinase 0.0662 0.5589 0.5589
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0723 0.1552
Echinococcus granulosus protein kinase c iota type 0.0063 0.0204 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0952 0.0952
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.007 0.0263 0.0222
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0176 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0723 0.1552
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0064 0.021 0.021
Trichomonas vaginalis AGC family protein kinase 0.013 0.0803 0.1735
Loa Loa (eye worm) histone deacetylase 3 0.0064 0.0216 0.0174
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0061 0.0186 0.0145
Loa Loa (eye worm) hypothetical protein 0.0064 0.0214 0.0173
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 0.0216 0.0396
Plasmodium falciparum calcium-dependent protein kinase 3 0.0061 0.0185 0.0326
Giardia lamblia Kinase, CMGC CLK 0.0148 0.0968 0.1975
Trypanosoma brucei protein kinase, putative 0.0058 0.0158 0.0266
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0061 0.0185 0.0158
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0122 0.0733 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.006 0.006
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0143 0.0921 0.0883
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0061 0.0186 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Trypanosoma brucei aurora B kinase 0.0533 0.443 1
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0733 0.1574
Entamoeba histolytica protein kinase, putative 0.0122 0.0733 0.1653
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0122 0.0733 0.0694
Toxoplasma gondii aurora kinase 0.0533 0.443 1
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0186 0.0186
Schistosoma mansoni cell adhesion molecule 0.006 0.0176 0.0176
Giardia lamblia Kinase, NEK 0.013 0.0803 0.1592
Brugia malayi Immunoglobulin I-set domain containing protein 0.0174 0.1199 0.1162
Trichomonas vaginalis STE family protein kinase 0.013 0.0803 0.1735
Loa Loa (eye worm) TK/FAK protein kinase 0.0305 0.2384 0.2352
Brugia malayi protein kinase C II. 0.0063 0.0204 0.0163
Echinococcus granulosus histone deacetylase 1 0.0064 0.0216 0.0174
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0148 0.0968 0.2111
Entamoeba histolytica protein kinase domain containing protein 0.0209 0.1515 0.3419
Loa Loa (eye worm) hypothetical protein 0.0064 0.021 0.0169
Leishmania major protein kinase, putative 0.0058 0.0158 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0117 0.0117
Schistosoma mansoni kinase 0.0069 0.0255 0.0255
Echinococcus multilocularis tyrosine protein kinase Src42A 0.01 0.0535 0.0495
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Giardia lamblia Kinase, CMGC CDK 0.0112 0.0639 0.1212
Schistosoma mansoni cell adhesion molecule 0.0064 0.021 0.021
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Plasmodium vivax protein kinase Crk2 0.0112 0.0639 0.1212
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0135 0.0855 0.0816
Plasmodium falciparum calcium-dependent protein kinase 5 0.0061 0.0185 0.0326
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0061 0.0186 0.0329
Echinococcus multilocularis tyrosine protein kinase shark 0.0056 0.0137 0.0096
Brugia malayi protein-tyrosine kinase 0.0087 0.0414 0.0374
Echinococcus multilocularis c src tyrosine kinase 0.0069 0.0258 0.0217
Brugia malayi p70 ribosomal S6 kinase beta 0.0047 0.006 0.0019
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0061 0.0185 0.0326
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.1067 0.1067
Trypanosoma cruzi casein kinase, putative 0.0061 0.0186 0.0329
Schistosoma mansoni tyrosine kinase 0.0104 0.057 0.057
Echinococcus granulosus tyrosine protein kinase Srms 0.0056 0.0137 0.0096
Echinococcus granulosus tyrosine protein kinase Fyn 0.01 0.0535 0.0495
Entamoeba histolytica casein kinase 1, putative 0.0061 0.0186 0.042
Loa Loa (eye worm) hypothetical protein 0.0064 0.0216 0.0174
Echinococcus granulosus defective proboscis extension response 0.012 0.0712 0.0673
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0205 0.0163
Giardia lamblia Aurora kinase 0.0533 0.443 1
Brugia malayi Protein kinase domain containing protein 0.0047 0.006 0.0019
Plasmodium vivax serine/threonine kinase-1, putative 0.0148 0.0968 0.1975
Loa Loa (eye worm) TK protein kinase 0.0087 0.0414 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.006 0.018 0.0138
Loa Loa (eye worm) hypothetical protein 0.0146 0.0947 0.0909
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0069 0.0255 0.0214
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.0216 0.0396
Schistosoma mansoni tyrosine kinase 0.0056 0.0137 0.0137
Echinococcus granulosus protein kinase C gamma type 0.0047 0.006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0064 0.0212 0.0171
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Plasmodium falciparum calcium-dependent protein kinase 1 0.0061 0.0185 0.0326
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.012 0.0712 0.0712
Plasmodium vivax casein kinase 1, putative 0.0061 0.0186 0.0161
Loa Loa (eye worm) hypothetical protein 0.006 0.0176 0.0135
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0334 0.2641 0.261
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.021 0.0169
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.1515 0.1515
Trypanosoma cruzi cdc2-related kinase 1 0.0112 0.0639 0.1362
Loa Loa (eye worm) hypothetical protein 0.012 0.0712 0.0673
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0189 0.1338 0.1424
Toxoplasma gondii histone deacetylase HDAC2 0.0064 0.0216 0.0396
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0976 0.8413 0.8406
Entamoeba histolytica p21-activated kinase 0.0041 0.0009 0.002
Brugia malayi SRC-1 0.01 0.0535 0.0495
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.102 0.0982
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Echinococcus granulosus microtubule associated protein 2 0.0728 0.6189 0.6173
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Brugia malayi Temporarily assigned gene name protein 59 0.0079 0.0351 0.031
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0209 0.1515 0.3357
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.0723 0.1552
Schistosoma mansoni protein kinase 0.0097 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0146 0.0947 0.0909
Trichomonas vaginalis STE family protein kinase 0.0177 0.123 0.2707
Schistosoma mansoni protein kinase 0.0334 0.2641 0.2641
Echinococcus granulosus cyclin dependent kinase 9 0.0069 0.0255 0.0214
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.0216 0.0396
Brugia malayi hypothetical protein 0.0123 0.0746 0.0707
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0063 0.0204 0.0163
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.016 0.0119
Trypanosoma cruzi casein kinase, putative 0.0061 0.0186 0.0329
Entamoeba histolytica protein kinase, putative 0.0533 0.443 1
Leishmania major histone deacetylase, putative 0.0064 0.0216 0.0396
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.006 0.006
Echinococcus multilocularis titin 0.0058 0.016 0.0119
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0047 0.006 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0212 0.0387
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0585 0.0585
Trichomonas vaginalis STE family protein kinase 0.0177 0.123 0.2707
Echinococcus multilocularis serine:threonine protein kinase 0.0064 0.0212 0.0171
Brugia malayi serine/threonine-protein kinase PAK 7 0.0214 0.1561 0.1526
Loa Loa (eye worm) hypothetical protein 0.0174 0.1204 0.1167
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.01 0.0535 0.0495
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0096 0.0501 0.0461
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0264 0.2013 0.198
Echinococcus granulosus insulin receptor 0.0506 0.4191 0.4167
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.1338 0.1338
Schistosoma mansoni atypical protein kinase C 0.0063 0.0204 0.0204
Trypanosoma brucei polo-like protein kinase 0.0121 0.0723 0.1552
Brugia malayi bone morphogenetic protein type 1 receptor 0.0112 0.0644 0.0604
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0112 0.0639 0.06
Echinococcus granulosus roundabout 2 0.0183 0.1286 0.125
Schistosoma mansoni protein kinase 0.0061 0.0186 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.2588 0.2588
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0061 0.0185 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0255 0.0255
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0723 0.1552
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0146 0.0952 0.0914
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0122 0.0733 0.0694
Trichomonas vaginalis CMGC family protein kinase 0.0122 0.0733 0.1574
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0102 0.055 0.0511
Leishmania major histone deacetylase, putative 0.0064 0.0216 0.0396
Onchocerca volvulus 0.0328 0.2588 0.2907
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0121 0.0723 0.0684
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0723 0.1552
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0143 0.0921 0.0883
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0117 0.0685 0.0645
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0117 0.0172
Echinococcus multilocularis tyrosine protein kinase otk 0.006 0.0176 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0042 0.0042
Brugia malayi ribosomal protein S6 kinase alpha 3 0.011 0.0623 0.0584
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0083 0.0384 0.0343
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0143 0.0921 0.0883
Echinococcus multilocularis tyrosine kinase 0.0056 0.0137 0.0096
Echinococcus granulosus tyrosine protein kinase Lyn 0.0121 0.0728 0.0689
Trichomonas vaginalis AGC family protein kinase 0.0533 0.443 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0052 0.01 0.0058
Onchocerca volvulus 0.0146 0.0947 0.096
Echinococcus multilocularis epidermal growth factor receptor 0.1152 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0101 0.0544 0.0504
Schistosoma mansoni serine/threonine kinase 0.0047 0.006 0.006
Brugia malayi Tyrosine-protein kinase abl-1 0.0134 0.0846 0.0807
Loa Loa (eye worm) hypothetical protein 0.0123 0.0746 0.0707
Brugia malayi Protein kinase domain containing protein 0.0506 0.4191 0.4167
Leishmania major protein kinase, putative 0.0148 0.0968 0.2111
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.006 0.006
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0061 0.0185 0.0144
Echinococcus multilocularis epidermal growth factor receptor 0.0662 0.5589 0.5571
Echinococcus granulosus cyclin dependent kinase 19 0.0159 0.1067 0.1029
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.01 0.0535 0.0495
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 0.0216 0.0396
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0061 0.0185 0.0144
Echinococcus multilocularis serine:threonine protein kinase 38 0.0047 0.006 0.0019
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0052 0.01 0.0058
Echinococcus granulosus casein kinase I alpha 0.0061 0.0186 0.0145
Plasmodium falciparum serine/threonine protein kinase, putative 0.0533 0.443 1
Echinococcus granulosus epidermal growth factor receptor 0.0662 0.5589 0.5571
Echinococcus multilocularis cyclin dependent kinase 0.0112 0.0639 0.06
Brugia malayi SH2 domain containing protein 0.0056 0.0137 0.0096
Toxoplasma gondii histone deacetylase HDAC3 0.0064 0.0216 0.0396
Echinococcus multilocularis tyrosine protein kinase Fyn 0.01 0.0535 0.0495
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0105 0.0585 0.1237
Schistosoma mansoni titin 0.0058 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0193 0.1371 0.1335
Loa Loa (eye worm) AUR protein kinase 0.0533 0.443 0.4407
Echinococcus multilocularis protein kinase c iota type 0.0063 0.0204 0.0163
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0533 0.443 1
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0042 0.0042
Entamoeba histolytica protein kinase, putative 0.0041 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0162 0.109 0.1053
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0968 0.2111
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0121 0.0723 0.0684
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0102 0.055 0.0511
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0105 0.0585 0.1237
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0042 0.0042
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0105 0.0585 0.0545
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0178 0.1233 0.1196
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0122 0.0733 0.0694
Brugia malayi histone deacetylase 1 (HD1) 0.0064 0.0216 0.0174
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0158 0.0266
Brugia malayi Protein kinase domain containing protein 0.0334 0.2641 0.261
Brugia malayi Protein kinase domain containing protein 0.0064 0.0212 0.0171
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0058 0.016 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.012 0.0712 0.0673
Loa Loa (eye worm) hypothetical protein 0.0079 0.0351 0.031
Echinococcus multilocularis TGF beta receptor type 1 0.0097 0.0507 0.0467
Brugia malayi Protein kinase domain containing protein 0.0056 0.0137 0.0096
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0117 0.0687 0.0648
Trypanosoma cruzi histone deacetylase 1, putative 0.0064 0.0216 0.0396
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0533 0.443 1
Echinococcus granulosus dual specificity 0.0209 0.1515 0.1479
Brugia malayi Protein kinase domain containing protein 0.0148 0.0968 0.093
Echinococcus granulosus casein kinase I delta 0.0061 0.0186 0.0145
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0154 0.102 0.2229
Brugia malayi Protein kinase domain containing protein 0.0056 0.0137 0.0096
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0117 0.0685 0.0645
Loa Loa (eye worm) hypothetical protein 0.018 0.1252 0.1215
Schistosoma mansoni protein kinase 0.0178 0.1233 0.1233
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0102 0.0556 0.0516
Brugia malayi Protein kinase domain containing protein 0.0209 0.1515 0.1479
Brugia malayi protein C17H12.11 0.0064 0.0214 0.0173
Onchocerca volvulus 0.0084 0.039 0.03
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0204 0.1474 0.3264
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0585 0.0585
Trypanosoma brucei cdc2-related kinase 3 0.0112 0.0639 0.1362
Trypanosoma brucei casein kinase I, isoform 2 0.0061 0.0186 0.0329
Plasmodium falciparum calcium-dependent protein kinase 4 0.0061 0.0185 0.0326
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.1114 0.9661 0.5
Echinococcus multilocularis cyclin dependent kinase 5 0.0112 0.0639 0.06
Echinococcus multilocularis dual specificity mitogen activated protein 0.0177 0.123 0.1193
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.102 0.0982
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0079 0.0351 0.0704
Echinococcus granulosus TGF-beta receptor type-1 0.0097 0.0507 0.0467
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0047 0.006 0.0019
Schistosoma mansoni kinase 0.0072 0.0282 0.0282
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0158 0.0357
Entamoeba histolytica protein kinase, putative 0.0061 0.0185 0.0417
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0147 0.0955 0.0917
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0556 0.0556
Entamoeba histolytica cell division protein kinase 2, putative 0.0112 0.0639 0.1443
Plasmodium vivax calcium-dependent protein kinase, putative 0.0061 0.0185 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0204 0.0204
Toxoplasma gondii AGC kinase 0.0105 0.0585 0.1237
Echinococcus granulosus protein tyrosine kinase 0.0302 0.2356 0.2324
Echinococcus multilocularis insulin receptor 0.0506 0.4191 0.4167
Entamoeba histolytica protein kinase domain containing protein 0.0533 0.443 1
Brugia malayi hypothetical protein 0.0079 0.0351 0.031
Echinococcus multilocularis transfer RNA-Thr 0.0211 0.1534 0.1498
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0687 0.0687
Echinococcus granulosus cyclin dependent kinase 0.0112 0.0639 0.06
Schistosoma mansoni vesicular amine transporter 0.012 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0105 0.0585 0.0545
Loa Loa (eye worm) hypothetical protein 0.0064 0.0214 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.007 0.027 0.0519
Brugia malayi P38 map kinase family protein 2 0.0154 0.102 0.0982
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Treponema pallidum licC protein (licC) 0.0204 0.1474 0.5
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0148 0.0968 0.2111
Onchocerca volvulus Tyrosine kinase homolog 0.097 0.836 0.9756
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.102 0.2229
Echinococcus multilocularis basement membrane specific heparan sulfate 0.012 0.0712 0.0673
Echinococcus multilocularis casein kinase I alpha 0.0061 0.0186 0.0145
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0061 0.0185 0.0158
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0047 0.006 0.0019
Echinococcus granulosus aurora kinase A 0.0533 0.443 0.4407
Giardia lamblia Kinase, CMGC CDK 0.0112 0.0639 0.1212
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0056 0.0137 0.0096
Echinococcus multilocularis casein kinase I alpha 0.0061 0.0186 0.0145
Echinococcus granulosus neuroglian 0.0153 0.1009 0.0972
Loa Loa (eye worm) hypothetical protein 0.0061 0.0185 0.0144
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0176 0.0135
Brugia malayi Tyrosine-protein kinase abl-1 0.0152 0.1007 0.0969
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0105 0.0585 0.1237
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0662 0.5589 0.5571
Schistosoma mansoni Neurotrimin precursor (hNT) 0.012 0.0712 0.0712
Brugia malayi Hr1 repeat family protein 0.0047 0.006 0.0019
Schistosoma mansoni protein kinase 0.0221 0.1627 0.1627
Brugia malayi Immunoglobulin I-set domain containing protein 0.0123 0.0746 0.0707
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.006 0.0176 0.0176
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0105 0.0585 0.0545
Loa Loa (eye worm) TK/ABL protein kinase 0.0273 0.2096 0.2063
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0083 0.0383 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0723 0.1552
Loa Loa (eye worm) hypothetical protein 0.0056 0.0137 0.0096
Echinococcus multilocularis tyrosine protein kinase Src64B 0.01 0.0535 0.0495
Entamoeba histolytica protein kinase, putative 0.0209 0.1515 0.3419
Schistosoma mansoni serine/threonine protein kinase 0.022 0.1616 0.1616
Brugia malayi protein unc-22 0.0058 0.016 0.0119
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0122 0.0733 0.0694
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0061 0.0185 0.0144
Entamoeba histolytica serine/threonine protein kinase, putative 0.0121 0.0723 0.1631
Schistosoma mansoni septate junction protein 0.006 0.0176 0.0176
Echinococcus multilocularis histone deacetylase 1 0.0064 0.0216 0.0174
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0047 0.006 0.0019
Loa Loa (eye worm) hypothetical protein 0.006 0.0176 0.0135
Echinococcus multilocularis protein KINase family member (kin 25) 0.0104 0.057 0.053
Entamoeba histolytica protein kinase, putative 0.0051 0.0093 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.2013 0.2013
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0176 0.0135
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.01 0.0535 0.0495
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0105 0.0585 0.1237
Brugia malayi Protein kinase domain containing protein 0.0189 0.1338 0.1301
Echinococcus multilocularis cyclin dependent kinase 19 0.0159 0.1067 0.1029
Brugia malayi Immunoglobulin I-set domain containing protein 0.1083 0.9382 0.9379
Echinococcus multilocularis serine:threonine protein kinase 0.0064 0.0212 0.0171
Entamoeba histolytica PH domain containing protein kinase, putative 0.0109 0.0617 0.1393
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0148 0.0968 0.093
Onchocerca volvulus Basement membrane proteoglycan homolog 0.006 0.0176 0.0046
Loa Loa (eye worm) hypothetical protein 0.0079 0.0351 0.031
Schistosoma mansoni protein kinase 0.0178 0.1233 0.1233
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0209 0.1518 0.1482
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.0255 0.0575
Leishmania major protein kinase, putative 0.0533 0.443 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0273
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0086 0.0407 0.0366
Echinococcus granulosus roundabout 2 0.0064 0.021 0.0169
Schistosoma mansoni tyrosine kinase 0.0625 0.5259 0.5259
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0148 0.0968 0.2111
Schistosoma mansoni tyrosine kinase 0.01 0.0535 0.0535
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.021 0.0169
Echinococcus multilocularis cyclin dependent kinase 7 0.0102 0.0556 0.0516
Onchocerca volvulus 0.0307 0.2395 0.2679
Trypanosoma cruzi aurora B kinase, putative 0.0533 0.443 1
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0639 0.1362
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0096 0.0501 0.0461
Echinococcus granulosus tyrosine protein kinase shark 0.0056 0.0137 0.0096
Echinococcus granulosus Vam6:Vps39 protein 0.0079 0.0351 0.031
Entamoeba histolytica protein kinase, putative 0.0051 0.0093 0.0209
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.007 0.0263 0.0222
Echinococcus granulosus protein kinase c epsilon type 0.0063 0.0204 0.0163
Trichomonas vaginalis CK1 family protein kinase 0.0061 0.0186 0.0329
Schistosoma mansoni tyrosine kinase 0.01 0.0535 0.0535
Brugia malayi SH2 domain containing protein 0.0056 0.0137 0.0096
Echinococcus granulosus fibroblast growth factor receptor 4 0.0141 0.0902 0.0864
Giardia lamblia Kinase, NEK 0.013 0.0803 0.1592
Entamoeba histolytica protein kinase, putative 0.0533 0.443 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.006 0.0176 0.0135
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0148 0.0968 0.2111
Echinococcus multilocularis casein kinase I delta 0.0061 0.0186 0.0145
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0189 0.1338 0.1301
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0185 0.0326
Echinococcus multilocularis lachesin 0.006 0.0176 0.0135
Schistosoma mansoni tyrosine kinase 0.0197 0.1412 0.1412
Brugia malayi Protein kinase domain containing protein 0.0047 0.006 0.0019
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1114 0.9661 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0955 0.0917
Loa Loa (eye worm) hypothetical protein 0.0123 0.0746 0.0707
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0474 0.3898 0.3872
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.102 0.0982
Plasmodium falciparum calcium-dependent protein kinase 2 0.0061 0.0185 0.0326
Trypanosoma cruzi casein kinase, putative 0.0061 0.0186 0.0329
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.022 0.1616 0.1581
Loa Loa (eye worm) hypothetical protein 0.0079 0.0351 0.031
Echinococcus multilocularis dual specificity protein kinase clk2 0.0148 0.0968 0.093
Onchocerca volvulus 0.0993 0.8566 1
Trypanosoma cruzi casein kinase, putative 0.0061 0.0186 0.0329
Echinococcus granulosus tyrosine protein kinase Src64B 0.01 0.0535 0.0495
Plasmodium falciparum protein kinase, putative 0.0058 0.0158 0.0266
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0061 0.0185 0.0326
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.0414 0.0374
Brugia malayi Histone deacetylase 1 0.0064 0.0216 0.0174
Echinococcus granulosus contactin 0.0064 0.021 0.0169
Giardia lamblia Kinase, STE STE20 0.0177 0.123 0.2581
Brugia malayi casein kinase I 0.0061 0.0186 0.0145
Giardia lamblia Kinase, CK1 Casein kinase 0.0061 0.0186 0.0161
Loa Loa (eye worm) hypothetical protein 0.051 0.4223 0.4199
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0104 0.057 0.053
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0177 0.123 0.2707
Echinococcus multilocularis aurora kinase A 0.0533 0.443 0.4407
Trichomonas vaginalis AGC family protein kinase 0.0533 0.443 1
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0585 0.0585
Echinococcus granulosus serine:threonine protein kinase 0.0064 0.0212 0.0171
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0198 0.1413 0.1377
Echinococcus granulosus tyrosine protein kinase otk 0.006 0.0176 0.0135
Trichomonas vaginalis CK1 family protein kinase 0.0061 0.0186 0.0329
Schistosoma mansoni microtubule-associated protein tau 0.0728 0.6189 0.6189
Entamoeba histolytica protein kinase, putative 0.0061 0.0185 0.0417
Brugia malayi Protein kinase domain containing protein 0.0051 0.0093 0.0051
Schistosoma mansoni rap gtpase-activating protein 0.0079 0.0351 0.0351
Giardia lamblia Kinase, AGC AKT 0.011 0.0623 0.1174
Loa Loa (eye worm) hypothetical protein 0.0143 0.0919 0.088
Echinococcus multilocularis tyrosine protein kinase Fyn 0.01 0.0535 0.0495
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0064 0.021 0.0169
Echinococcus granulosus lachesin 0.006 0.0176 0.0135
Schistosoma mansoni protein kinase 0.0221 0.1627 0.1627
Echinococcus multilocularis tyrosine protein kinase Srms 0.0087 0.0414 0.0374
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0053 0.0117 0.0076
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.006 0.0176 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0047 0.006 0.0042
Giardia lamblia Kinase, NEK 0.013 0.0803 0.1592
Schistosoma mansoni protein kinase 0.0112 0.0644 0.0644
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0112 0.0639 0.06
Brugia malayi Protein kinase domain containing protein 0.0576 0.4822 0.4801
Schistosoma mansoni cell adhesion molecule 0.015 0.0989 0.0989
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0105 0.0585 0.1237
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0086 0.0407 0.0367
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1083 0.9382 0.9379
Echinococcus granulosus mitogen activated protein kinase 11 0.0154 0.102 0.0982
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0639 0.0639
Echinococcus multilocularis cyclin dependent kinase 9 0.0069 0.0255 0.0214
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.1114 0.9661 1
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0079 0.0351 0.0704
Onchocerca volvulus 0.0064 0.0214 0.0091
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0122 0.0733 0.1574
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0533 0.443 0.4407
Trypanosoma brucei histone deacetylase 1 0.0064 0.0216 0.0396
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0112 0.0639 0.06
Brugia malayi serine/threonine kinase 12 0.0533 0.443 0.4407
Echinococcus multilocularis cyclin dependent kinase 9 0.0077 0.0329 0.0289
Brugia malayi cell division control protein 2 homolog 0.0112 0.0639 0.06
Brugia malayi Protein kinase domain containing protein 0.0993 0.8566 0.856
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.0733 0.1653
Schistosoma mansoni tyrosine kinase 0.0069 0.0258 0.0258
Schistosoma mansoni protein kinase 0.0178 0.1233 0.1233
Loa Loa (eye worm) AGC/PKA protein kinase 0.0105 0.0585 0.0545
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0105 0.0585 0.1237
Echinococcus granulosus peroxidasin 0.006 0.018 0.0138
Loa Loa (eye worm) hypothetical protein 0.0146 0.0947 0.0909
Echinococcus granulosus hypothetical protein 0.0127 0.0776 0.0737
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.01 0.0535 0.0495
Schistosoma mansoni tyrosine kinase 0.1152 1 1
Brugia malayi hypothetical protein 0.0056 0.0137 0.0096
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0334 0.2641 0.261
Loa Loa (eye worm) TK protein kinase 0.0067 0.0243 0.0202
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0061 0.0185 0.0326
Giardia lamblia Kinase, PLK 0.0121 0.0723 0.1405
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0113 0.0656 0.1398
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0105 0.0585 0.0545
Toxoplasma gondii casein kinase I 0.0061 0.0186 0.0329
Echinococcus granulosus Protein kinase C brain isozyme 0.0063 0.0204 0.0163
Echinococcus granulosus casein kinase i 0.0061 0.0186 0.0145
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0096 0.0501 0.0461
Schistosoma mansoni roundabout 0.006 0.0176 0.0176
Plasmodium falciparum histone deacetylase 1 0.0064 0.0216 0.0396
Onchocerca volvulus 0.0061 0.0186 0.0058
Loa Loa (eye worm) TK protein kinase 0.0174 0.1199 0.1162
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0061 0.0185 0.0158
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0148 0.0968 0.2111
Entamoeba histolytica hypothetical protein 0.0209 0.1515 0.3419
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0064 0.021 0.0169
Echinococcus multilocularis protein kinase shaggy 0.0122 0.0733 0.0694
Leishmania major protein kinase A catalytic subunit isoform 1 0.0105 0.0585 0.1237
Loa Loa (eye worm) hypothetical protein 0.0127 0.0776 0.0737
Leishmania major protein kinase, putative 0.0148 0.0968 0.2111
Schistosoma mansoni serine/threonine kinase 0.0062 0.0192 0.0192
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Echinococcus granulosus tyrosine kinase 0.0056 0.0137 0.0096
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0141 0.0902 0.0864
Giardia lamblia Histone deacetylase 0.0064 0.0216 0.0229
Schistosoma mansoni tyrosine kinase 0.0053 0.0114 0.0114
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.01 0.0535 0.0495
Echinococcus multilocularis tyrosine protein kinase Abl 0.0152 0.1007 0.0969
Echinococcus granulosus calcium activated potassium channel 0.0053 0.0117 0.0076
Schistosoma mansoni nephrin 0.0064 0.021 0.021
Brugia malayi cyclin-dependent kinase 7 homolog 0.0111 0.063 0.0591
Echinococcus granulosus cyclin dependent kinase 5 0.0112 0.0639 0.06
Trypanosoma brucei cdc2-related kinase 1 0.0112 0.0639 0.1362
Echinococcus multilocularis casein kinase i 0.0061 0.0186 0.0145
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0154 0.102 0.2229
Echinococcus granulosus dual specificity protein kinase clk2 0.0148 0.0968 0.093
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0064 0.021 0.0169
Trichomonas vaginalis CAMK family protein kinase 0.0129 0.0798 0.1722
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1042 0.1042
Entamoeba histolytica tyrosin kinase, putative 0.0044 0.0033 0.0075
Echinococcus multilocularis 0.0346 0.2749 0.2719
Echinococcus multilocularis roundabout 2 0.0064 0.021 0.0169
Entamoeba histolytica protein kinase, putative 0.0047 0.006 0.0136
Trichomonas vaginalis CK1 family protein kinase 0.0061 0.0186 0.0329
Brugia malayi probable protein kinase 0.0164 0.1111 0.1074
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1413 0.1413
Giardia lamblia Kinase, CMGC GSK 0.0122 0.0733 0.1428
Brugia malayi Protein kinase domain containing protein 0.0198 0.1413 0.1377
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0639 0.1362
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0148 0.0968 0.2111
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0105 0.0585 0.0545
Schistosoma mansoni tyrosine kinase 0.0506 0.4191 0.4191
Schistosoma mansoni cell adhesion molecule 0.0064 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0211 0.1534 0.1498
Schistosoma mansoni protein kinase 0.0177 0.123 0.123
Loa Loa (eye worm) histone deacetylase 1 0.0064 0.0216 0.0174
Echinococcus multilocularis tyrosine protein kinase HCK 0.0067 0.0243 0.0202
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0058 0.0158 0.0266
Loa Loa (eye worm) TK/INSR protein kinase 0.0506 0.4191 0.4167
Loa Loa (eye worm) hypothetical protein 0.012 0.0715 0.0676
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.0216 0.0396
Schistosoma mansoni tyrosine kinase 0.0069 0.0258 0.0258
Echinococcus multilocularis tyrosine protein kinase Fgr 0.01 0.0535 0.0495
Echinococcus granulosus tyrosine protein kinase Src42A 0.01 0.0535 0.0495
Plasmodium falciparum NIMA related kinase 1 0.013 0.0803 0.1735
Brugia malayi Protein kinase domain containing protein 0.0211 0.1534 0.1498
Loa Loa (eye worm) hypothetical protein 0.006 0.0176 0.0135
Echinococcus granulosus histone deacetylase 3 0.0064 0.0216 0.0174
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0143 0.0919 0.088
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0533 0.443 0.4407
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0112 0.0644 0.0604
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0064 0.021 0.0169
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0273 0.2096 0.2063
Echinococcus granulosus casein kinase I alpha 0.0061 0.0186 0.0145
Entamoeba histolytica protein kinase, putative 0.0209 0.1515 0.3419
Brugia malayi Protein kinase domain containing protein 0.0159 0.1067 0.1029
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0105 0.0585 0.1237
Echinococcus multilocularis roundabout 2 0.0183 0.1286 0.125
Schistosoma mansoni tyrosine kinase 0.0625 0.5259 0.5259
Echinococcus granulosus c-Jun N-terminal kinases 0.0264 0.2013 0.198
Loa Loa (eye worm) hypothetical protein 0.006 0.0176 0.0135
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.051 0.4226 0.4201
Echinococcus granulosus TGF beta receptor type 1 0.0097 0.0507 0.0467
Giardia lamblia Kinase, CMGC GSK 0.0122 0.0733 0.1428
Echinococcus multilocularis casein kinase I alpha 0.0061 0.0186 0.0145
Brugia malayi Serine/threonine-protein kinase SULU 0.022 0.1616 0.1581
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Echinococcus multilocularis calcium activated potassium channel 0.0053 0.0117 0.0076
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0061 0.0185 0.0144
Echinococcus multilocularis protein kinase c epsilon type 0.0063 0.0204 0.0163
Brugia malayi Protein kinase domain containing protein 0.0112 0.0644 0.0604
Echinococcus multilocularis rho associated protein kinase 0.0328 0.2588 0.2557
Schistosoma mansoni protein kinase 0.0058 0.0158 0.0158
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0158 0.0266
Echinococcus granulosus casein kinase I delta 0.0061 0.0186 0.0145
Loa Loa (eye worm) AGC/AKT protein kinase 0.0051 0.0093 0.0051
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0121 0.0723 0.1552
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0221 0.1627 0.1592
Echinococcus multilocularis activated cdc42 kinase 1 0.0211 0.1534 0.1498
Schistosoma mansoni neuroglian 0.0064 0.021 0.021
Echinococcus granulosus NDR protein kinase 0.0047 0.006 0.0019
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0135 0.0855 0.0816
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0079 0.0351 0.0351
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0533 0.443 1
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0079 0.0351 0.031
Entamoeba histolytica casein kinase, putative 0.0061 0.0186 0.042
Echinococcus multilocularis tyrosine protein kinase Fyn 0.01 0.0535 0.0495
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0047 0.006 0.0019
Plasmodium vivax glycogen synthase kinase 3, putative 0.0122 0.0733 0.1428
Entamoeba histolytica histone deacetylase, putative 0.0064 0.0216 0.0486
Loa Loa (eye worm) gastrulation defective protein 1 0.0138 0.0874 0.0836
Brugia malayi Stress-activated protein kinase jnk-1 0.0264 0.2013 0.198
Loa Loa (eye worm) TK/ROR protein kinase 0.007 0.0263 0.0222
Echinococcus multilocularis activin receptor type 0.0443 0.3621 0.3594
Echinococcus multilocularis cyclin dependent kinase 1 0.0112 0.0639 0.06
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0209 0.1515 0.3357
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0968 0.0968
Brugia malayi Protein kinase domain containing protein 0.0112 0.0639 0.06
Giardia lamblia Kinase, AGC PKA 0.0105 0.0585 0.1085
Brugia malayi histone deacetylase 3 (HD3) 0.0064 0.0216 0.0174
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0079 0.0351 0.0351
Brugia malayi Protein kinase domain containing protein 0.0086 0.0407 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0639 0.0639
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0209 0.1515 0.3357
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0141 0.0902 0.0864
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0061 0.0186 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0117 0.0117
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0143 0.0921 0.0883
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0177 0.123 0.2707
Echinococcus multilocularis tyrosine protein kinase Blk 0.0087 0.0414 0.0374
Echinococcus granulosus epidermal growth factor receptor 0.1152 1 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0447 0.0407
Leishmania major protein kinase A catalytic subunit 0.0105 0.0585 0.1237
Onchocerca volvulus Serine\/threonine kinase homolog 0.0121 0.0723 0.0694
Echinococcus granulosus mitogen activated protein kinase 14 0.0154 0.102 0.0982
Plasmodium falciparum casein kinase 1 0.0061 0.0186 0.0329
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0177 0.123 0.1193
Onchocerca volvulus 0.008 0.0358 0.0261
Brugia malayi casein kinase 1, delta 0.0061 0.0186 0.0145
Schistosoma mansoni septate junction protein 0.006 0.0176 0.0176
Brugia malayi C1-like domain containing protein 0.0102 0.055 0.0511
Leishmania major protein kinase, putative 0.0061 0.0185 0.0326
Entamoeba histolytica protein kinase, putative 0.0047 0.006 0.0136
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0159 0.1067 0.1029
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0146 0.0952 0.0914
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0093 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0204 0.0204
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0064 0.021 0.0169
Echinococcus granulosus tyrosine protein kinase Fyn 0.01 0.0535 0.0495
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0105 0.0585 0.0545
Brugia malayi hypothetical protein 0.022 0.1616 0.1581
Loa Loa (eye worm) SRC-1 0.01 0.0535 0.0495
Loa Loa (eye worm) AGC/PKN protein kinase 0.0047 0.006 0.0019
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0112 0.0639 0.06
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0069 0.0258 0.0258
Onchocerca volvulus 0.0122 0.0733 0.0706
Brugia malayi serine/threonine-protein kinase 6 0.0533 0.443 0.4407
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0177 0.123 0.1193
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0061 0.0185 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0855 0.0855
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0156 0.1042 0.1005
Schistosoma mansoni protein kinase 0.0084 0.0396 0.0396
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0189 0.1338 0.1301
Echinococcus granulosus cyclin dependent kinase 1 0.0112 0.0639 0.06
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0042 0.0042
Echinococcus multilocularis death associated protein kinase 1 0.0877 0.7529 0.7519
Onchocerca volvulus 0.09 0.7733 0.9012
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0198 0.1413 0.1377
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0084 0.0396 0.0356
Echinococcus granulosus tyrosine protein kinase ABL1 0.0273 0.2096 0.2063
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.102 0.0982
Brugia malayi Peroxidasin 0.006 0.018 0.0138
Loa Loa (eye worm) CAMK protein kinase 0.0058 0.016 0.0119
Trypanosoma cruzi cdc2-related kinase 3 0.0112 0.0639 0.1362
Plasmodium falciparum protein kinase 5 0.0112 0.0639 0.1362
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0063 0.0205 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0185 0.0185
Trypanosoma brucei protein kinase, putative 0.0122 0.0733 0.1574
Echinococcus multilocularis Immunoglobulin 0.012 0.0712 0.0673
Trypanosoma cruzi histone deacetylase 1, putative 0.0064 0.0216 0.0396
Entamoeba histolytica protein kinase domain containing protein 0.0122 0.0733 0.1653
Leishmania major protein kinase A catalytic subunit isoform 2 0.0105 0.0585 0.1237
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0117 0.0687 0.0648
Schistosoma mansoni tyrosine kinase 0.0254 0.1925 0.1925
Loa Loa (eye worm) hypothetical protein 0.0123 0.0746 0.0707
Schistosoma mansoni serine/threonine protein kinase 0.0533 0.443 0.443
Echinococcus granulosus hemicentin 1 0.006 0.0176 0.0135
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0084 0.0392 0.0352
Brugia malayi Protein kinase domain containing protein 0.0305 0.2384 0.2352
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 0.0216 0.0396
Loa Loa (eye worm) AUR protein kinase 0.0533 0.443 0.4407
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0156 0.1042 0.1005
Schistosoma mansoni tyrosine kinase 0.0097 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0067 0.024 0.0199
Schistosoma mansoni tyrosine kinase 0.0625 0.5259 0.5259
Brugia malayi Prion-like- 0.006 0.0176 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0126 0.0126
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0135 0.0855 0.0816
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0061 0.0185 0.0144
Echinococcus multilocularis raf serine:threonine protein kinase 0.0053 0.0109 0.0068
Schistosoma mansoni titin 0.006 0.0176 0.0176
Echinococcus granulosus titin 0.0058 0.016 0.0119
Echinococcus multilocularis histone deacetylase 3 0.0064 0.0216 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0135 0.0212
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0087 0.0414 0.0374
Loa Loa (eye worm) hypothetical protein 0.006 0.0176 0.0135
Echinococcus multilocularis dual specificity 0.0209 0.1515 0.1479
Entamoeba histolytica protein kinase , putative 0.0533 0.443 1
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0137 0.0096
Loa Loa (eye worm) TK/ALK protein kinase 0.0576 0.4821 0.4799
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.006 0.0019
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0079 0.0351 0.0704
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0105 0.0585 0.1237
Loa Loa (eye worm) hypothetical protein 0.018 0.1252 0.1215
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0122 0.0733 0.1574
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0687 0.0687
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0084 0.0392 0.0352
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0334 0.2641 0.261
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0105 0.0585 0.0545
Echinococcus multilocularis neuroglian 0.0153 0.1009 0.0972
Echinococcus granulosus tyrosine kinase 0.0087 0.0414 0.0374
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0154 0.102 0.0982
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0056 0.0137 0.031
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0105 0.0585 0.0545
Echinococcus multilocularis neuroglian 0.0064 0.021 0.0169
Brugia malayi Protein kinase domain containing protein 0.0053 0.0117 0.0076
Trichomonas vaginalis STE family protein kinase 0.0177 0.123 0.2707
Echinococcus multilocularis 0.0084 0.0396 0.0356
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0079 0.0351 0.031
Schistosoma mansoni tyrosine kinase 0.0302 0.2356 0.2356
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0061 0.0185 0.0144
Brugia malayi serine/threonine protein kinase 6 0.0533 0.443 0.4407
Loa Loa (eye worm) IKK protein kinase 0.0993 0.8566 0.856
Trichomonas vaginalis histone deacetylase, putative 0.0064 0.0216 0.0396
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0105 0.0585 0.1085
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.016 0.016
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0209 0.1515 0.1479
Trypanosoma brucei rac serine-threonine kinase, putative 0.0051 0.0093 0.0116
Onchocerca volvulus 0.0079 0.0351 0.0253
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0177 0.123 0.2707

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.32 mM Inhibition of PAD4 (unknown origin) at 37 degC ChEMBL. 23421315
IC50 (binding) = 2.65 mM Inhibition of PAD4 (unknown origin) at 52 degC ChEMBL. 23421315
Ki (binding) = 115 uM Inhibition of PAD4 (unknown origin) at 37 degC ChEMBL. 23421315
Ki (binding) = 231 uM Inhibition of PAD4 (unknown origin) at 52 degC ChEMBL. 23421315

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.