Detailed information for compound 1741567

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.853 | Formula: C22H21ClO3
  • H donors: 0 H acceptors: 1 LogP: 5.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1)OC)/C=C/1\CCC/C(=C\c2ccccc2Cl)/C1=O
  • InChi: 1S/C22H21ClO3/c1-25-19-11-15(12-20(14-19)26-2)10-17-7-5-8-18(22(17)24)13-16-6-3-4-9-21(16)23/h3-4,6,9-14H,5,7-8H2,1-2H3/b17-10+,18-13+
  • InChiKey: HTECUFCXSIPTNC-YAUBYZHOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens xanthine dehydrogenase References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL Get druggable targets OG5_127252 All targets in OG5_127252
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis xanthine dehydrogenase, putative Get druggable targets OG5_127252 All targets in OG5_127252
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) Get druggable targets OG5_127252 All targets in OG5_127252
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Mycobacterium ulcerans carbon monoxide dehydrogenase Get druggable targets OG5_127252 All targets in OG5_127252
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis xanthine dehydrogenase, putative Get druggable targets OG5_127252 All targets in OG5_127252
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis aldehyde oxidase, putative Get druggable targets OG5_127252 All targets in OG5_127252
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 Get druggable targets OG5_127252 All targets in OG5_127252
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0471 0.3729 0.3727
Brugia malayi hypothetical protein 0.0078 0.034 0.0295
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.0686 0.1829
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0608 0.0608
Brugia malayi intracellular kinase 0.0119 0.0695 0.0652
Loa Loa (eye worm) hypothetical protein 0.012 0.0701 0.0658
Brugia malayi Protein kinase domain containing protein 0.0108 0.0605 0.0561
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0063 0.0214 0.0454
Leishmania major protein kinase, putative 0.0145 0.0917 0.2363
Echinococcus granulosus titin 0.0052 0.0118 0.0114
Schistosoma mansoni histone deacetylase 0.0063 0.0214 0.0214
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.0214 0.0454
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0204 0.143 0.139
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0039
Loa Loa (eye worm) hypothetical protein 0.0103 0.0556 0.0512
Schistosoma mansoni septate junction protein 0.0048 0.0086 0.0086
Schistosoma mansoni tyrosine kinase 0.0083 0.0385 0.0385
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.1816 0.1816
Trichomonas vaginalis AGC family protein kinase 0.0471 0.3729 1
Echinococcus multilocularis activin receptor type 0.0432 0.3397 0.3395
Leishmania major protein kinase, putative 0.0055 0.0145 0.0268
Schistosoma mansoni protein kinase 0.0059 0.0182 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0117 0.0117
Schistosoma mansoni protein kinase 0.0215 0.1525 0.1525
Leishmania major protein kinase, putative 0.0471 0.3729 1
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0039
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.015 0.0965 0.2579
Echinococcus granulosus neuroglian 0.0127 0.0764 0.076
Loa Loa (eye worm) TK/INSR protein kinase 0.0517 0.4129 0.4101
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0044 0.0046 0.0112
Schistosoma mansoni histone deacetylase 0.0063 0.0214 0.0214
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.012 0.0701 0.0698
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0135
Loa Loa (eye worm) hypothetical protein 0.0143 0.09 0.0858
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0145 0.0917 0.2449
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0173 0.1162 0.3108
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0258 0.1898 0.186
Schistosoma mansoni atypical protein kinase C 0.0061 0.0199 0.0199
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0046 0.0064 0.006
Loa Loa (eye worm) hypothetical protein 0.0078 0.034 0.0295
Brugia malayi hypothetical protein 0.0215 0.1525 0.1485
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0097 0.0503 0.0499
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0521 0.4161 0.4159
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.5824 0.5823
Loa Loa (eye worm) TK protein kinase 0.0083 0.0389 0.0344
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0204 0.1426 0.1423
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0204 0.143 0.3757
Echinococcus granulosus tyrosine kinase 0.0053 0.0129 0.0126
Plasmodium vivax serine/threonine kinase-1, putative 0.0145 0.0917 0.2215
Plasmodium vivax casein kinase 1, putative 0.0059 0.0182 0.0181
Echinococcus multilocularis protein KINase family member (kin 25) 0.01 0.0535 0.0532
Loa Loa (eye worm) hypothetical protein 0.0053 0.0129 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0103 0.0556 0.1385
Echinococcus granulosus hypothetical protein 0.0124 0.0739 0.0736
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0145 0.0378
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0099 0.052 0.1145
Trichomonas vaginalis CK1 family protein kinase 0.0059 0.0182 0.0368
Brugia malayi Immunoglobulin I-set domain containing protein 0.0164 0.1087 0.1045
Echinococcus multilocularis histone deacetylase 1 0.0063 0.0214 0.021
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0059 0.0181 0.0177
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0137 0.0847 0.0844
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0062 0.0208 0.0204
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0118 0.0686 0.1737
Echinococcus multilocularis epidermal growth factor receptor 0.1197 1 1
Trypanosoma brucei cdc2-related kinase 1 0.0109 0.0608 0.1524
Onchocerca volvulus 0.0078 0.034 0.0417
Loa Loa (eye worm) TK/EGFR protein kinase 0.1197 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0917 0.0917
Echinococcus multilocularis protein kinase c iota type 0.0061 0.0199 0.0195
Plasmodium falciparum NIMA related kinase 1 0.0127 0.0761 0.1941
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0052 0.0118 0.0114
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0193 0.1334 0.1331
Echinococcus granulosus serine:threonine kinase SAD 1 0.0044 0.0046 0.0043
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0109 0.0608 0.0564
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.1264 0.1264
Loa Loa (eye worm) gastrulation defective protein 1 0.0135 0.0832 0.0789
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0082 0.0379 0.0334
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0556 0.0556
Echinococcus granulosus casein kinase i 0.0059 0.0182 0.0179
Loa Loa (eye worm) hypothetical protein 0.0078 0.034 0.0295
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0204 0.143 0.3827
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0059 0.0181 0.0365
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Echinococcus granulosus protein kinase c iota type 0.0061 0.0199 0.0195
Trypanosoma brucei protein kinase, putative 0.0055 0.0145 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0181 0.0181
Schistosoma mansoni tyrosine kinase 0.0685 0.5574 0.5574
Trypanosoma brucei histone deacetylase 1 0.0063 0.0214 0.0454
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0185 0.1264 0.1261
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0143 0.0901 0.0859
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0086 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0086 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0608 0.0608
Schistosoma mansoni protein kinase 0.0082 0.0379 0.0379
Echinococcus multilocularis serine:threonine protein kinase N2 0.0046 0.0064 0.006
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0552 0.4435 0.5
Echinococcus multilocularis roundabout 2 0.0052 0.0118 0.0114
Echinococcus multilocularis neuroglian 0.0127 0.0764 0.076
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0155 0.1009 0.0967
Entamoeba histolytica protein kinase, putative 0.0119 0.0695 0.1848
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0094 0.0477 0.0474
Loa Loa (eye worm) hypothetical protein 0.0063 0.0212 0.0166
Onchocerca volvulus Tyrosine kinase homolog 0.0676 0.5505 0.6834
Schistosoma mansoni serine/threonine kinase 0.0046 0.0064 0.0064
Schistosoma mansoni protein kinase 0.0173 0.1162 0.1162
Echinococcus granulosus NDR protein kinase 0.0046 0.0064 0.006
Schistosoma mansoni protein kinase 0.0215 0.1525 0.1525
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0103 0.0556 0.1481
Loa Loa (eye worm) hypothetical protein 0.0158 0.1035 0.0993
Brugia malayi Protein kinase domain containing protein 0.0046 0.0064 0.0017
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0139 0.0872 0.0829
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0686 0.1737
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0317 0.0313
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0098 0.0518 0.0514
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0145 0.0917 0.2363
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0103 0.0556 0.0553
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0695 0.1761
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0215 0.1525 0.1522
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0761 0.1941
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0119 0.0695 0.1761
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0209 0.1473 0.1434
Loa Loa (eye worm) hypothetical protein 0.0082 0.0377 0.0332
Onchocerca volvulus 0.0053 0.0129 0.0155
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0145 0.0371
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0081 0.0367 0.0363
Schistosoma mansoni protein kinase 0.0173 0.1166 0.1166
Loa Loa (eye worm) hypothetical protein 0.0063 0.0212 0.0166
Plasmodium falciparum glycogen synthase kinase 3 0.0119 0.0695 0.1761
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0071 0.0278 0.0599
Schistosoma mansoni nephrin 0.0052 0.0118 0.0118
Echinococcus granulosus insulin receptor 0.0517 0.4129 0.4127
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.0389 0.0386
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0118 0.0072
Schistosoma mansoni septate junction protein 0.0048 0.0086 0.0086
Toxoplasma gondii histone deacetylase HDAC2 0.0063 0.0214 0.0454
Entamoeba histolytica cell division protein kinase 2, putative 0.0109 0.0608 0.1613
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0139 0.0872 0.0829
Schistosoma mansoni roundabout 0.0048 0.0086 0.0086
Echinococcus granulosus casein kinase I alpha 0.0059 0.0182 0.0179
Toxoplasma gondii AGC kinase 0.0103 0.0556 0.1385
Entamoeba histolytica protein kinase , putative 0.0471 0.3729 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.1295 0.1254
Trypanosoma cruzi casein kinase, putative 0.0059 0.0182 0.0476
Trypanosoma cruzi cdc2-related kinase 1 0.0109 0.0608 0.1619
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0064 0.0064
Echinococcus granulosus activated cdc42 kinase 1 0.0205 0.1441 0.1438
Trypanosoma brucei polo-like protein kinase 0.0118 0.0686 0.1737
Echinococcus multilocularis casein kinase I alpha 0.0059 0.0182 0.0179
Onchocerca volvulus 0.0972 0.8053 1
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0901 0.0901
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0086 0.0039
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0204 0.143 0.3827
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0109 0.0608 0.0564
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0118 0.0686 0.0643
Echinococcus multilocularis dual specificity mitogen activated protein 0.0173 0.1162 0.1159
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0061 0.0199 0.0195
Echinococcus granulosus cyclin dependent kinase 7 0.01 0.0529 0.0526
Loa Loa (eye worm) hypothetical protein 0.0066 0.0236 0.019
Brugia malayi Protein kinase domain containing protein 0.0052 0.0117 0.0071
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0955 0.791 0.79
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0206 0.0434
Schistosoma mansoni titin 0.0052 0.0118 0.0118
Toxoplasma gondii casein kinase I 0.0059 0.0182 0.0368
Echinococcus multilocularis cyclin dependent kinase 5 0.0109 0.0608 0.0604
Schistosoma mansoni protein kinase 0.0173 0.1166 0.1166
Echinococcus multilocularis mitogen activated protein kinase 14 0.015 0.0965 0.0962
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0143 0.0901 0.0859
Brugia malayi Protein kinase domain containing protein 0.0155 0.1009 0.0967
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0139 0.0865 0.1925
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0059 0.0182 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0608 0.1524
Echinococcus multilocularis casein kinase I alpha 0.0059 0.0182 0.0179
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0471 0.3729 0.3729
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0078 0.034 0.034
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0139 0.0872 0.0869
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0103 0.0556 0.1385
Giardia lamblia Kinase, NEK 0.0127 0.0761 0.1785
Trypanosoma brucei aurora B kinase 0.0471 0.3729 1
Schistosoma mansoni tyrosine kinase 0.0097 0.0503 0.0503
Brugia malayi Protein kinase domain containing protein 0.0053 0.0129 0.0083
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0103 0.0556 0.0553
Echinococcus granulosus tyrosine protein kinase shark 0.0053 0.0129 0.0126
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0137 0.0847 0.0844
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0556 0.0556
Brugia malayi SRC-1 0.0097 0.0503 0.0458
Brugia malayi histone deacetylase 3 (HD3) 0.0063 0.0214 0.0168
Giardia lamblia Kinase, CMGC CDK 0.0109 0.0608 0.1359
Echinococcus granulosus casein kinase I delta 0.0059 0.0182 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0529 0.0529
Onchocerca volvulus 0.0063 0.0212 0.0258
Echinococcus multilocularis titin 0.0052 0.0118 0.0114
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0552 0.4435 1
Entamoeba histolytica casein kinase, putative 0.0059 0.0182 0.0469
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0185 0.1264 0.1223
Trypanosoma cruzi cdc2-related kinase 1 0.0109 0.0608 0.1619
Echinococcus multilocularis casein kinase I alpha 0.0059 0.0182 0.0179
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0059 0.0181 0.0177
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0327 0.2487 0.2485
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0103 0.0556 0.1217
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0107 0.0592 0.0548
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0119 0.0695 0.0692
Brugia malayi Protein kinase domain containing protein 0.0972 0.8053 0.8044
Schistosoma mansoni serine/threonine kinase 0.006 0.0187 0.0187
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0145 0.0378
Brugia malayi protein-tyrosine kinase 0.0083 0.0389 0.0344
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0081 0.0367 0.0322
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0061 0.0199 0.0153
Entamoeba histolytica cell division protein kinase 2, putative 0.0117 0.0678 0.1801
Brugia malayi Fibronectin type III domain containing protein 0.0103 0.0556 0.0512
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0062 0.0206 0.016
Leishmania major histone deacetylase, putative 0.0063 0.0214 0.0454
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0543 0.1197
Giardia lamblia Kinase, CMGC GSK 0.0119 0.0695 0.1601
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0063 0.0214 0.0454
Trypanosoma brucei cdc2-related kinase 3 0.0109 0.0608 0.1524
Schistosoma mansoni tyrosine kinase 0.0137 0.0847 0.0847
Brugia malayi Protein kinase domain containing protein 0.0062 0.0206 0.016
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Trypanosoma cruzi cdc2-related kinase 3 0.0109 0.0608 0.1619
Echinococcus granulosus c-Jun N-terminal kinases 0.0258 0.1898 0.1895
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0103 0.0556 0.1385
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0063 0.0214 0.0454
Echinococcus granulosus tyrosine protein kinase Src42A 0.0097 0.0503 0.0499
Echinococcus multilocularis roundabout 2 0.0052 0.0118 0.0114
Plasmodium falciparum calcium-dependent protein kinase 2 0.0059 0.0181 0.0365
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0109 0.0608 0.1524
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0118 0.0686 0.0683
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.0503 0.0499
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0099 0.052 0.1145
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0083 0.0389 0.0344
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0081 0.0367 0.0364
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.0104 0.0101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0214 0.0168
Echinococcus multilocularis epidermal growth factor receptor 0.0685 0.5574 0.5573
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0652 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0199 0.0199
Echinococcus granulosus casein kinase I delta 0.0059 0.0182 0.0179
Echinococcus granulosus mitogen activated protein kinase 11 0.015 0.0965 0.0962
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0062 0.0204 0.0431
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.0181 0.0365
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0048 0.0086 0.0101
Brugia malayi P38 map kinase family protein 2 0.015 0.0965 0.0923
Echinococcus granulosus dual specificity mitogen activated protein 0.0173 0.1162 0.1159
Echinococcus granulosus protein kinase c epsilon type 0.0061 0.0199 0.0195
Echinococcus granulosus histone deacetylase 1 0.0063 0.0214 0.021
Echinococcus granulosus tyrosine protein kinase Blk 0.0083 0.0389 0.0386
Schistosoma mansoni tyrosine kinase 0.0067 0.0243 0.0243
Echinococcus granulosus serine:threonine protein kinase 0.0062 0.0206 0.0203
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0756 0.1927
Plasmodium vivax protein kinase Crk2 0.0109 0.0608 0.1359
Echinococcus granulosus raf serine:threonine protein kinase 0.005 0.0103 0.0099
Brugia malayi Protein kinase domain containing protein 0.0053 0.0129 0.0083
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0109 0.0608 0.0604
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0057 0.0163 0.0117
Trypanosoma cruzi histone deacetylase 1, putative 0.0063 0.0214 0.0561
Entamoeba histolytica protein kinase, putative 0.0046 0.0064 0.0152
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0118 0.0072
Echinococcus granulosus serine:threonine protein kinase mig 15 0.014 0.0873 0.087
Brugia malayi probable protein kinase 0.016 0.1051 0.1009
Onchocerca volvulus 0.0053 0.0129 0.0155
Plasmodium falciparum calcium-dependent protein kinase 5 0.0059 0.0181 0.0365
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0097 0.0503 0.0499
Trypanosoma cruzi casein kinase, putative 0.0059 0.0182 0.0476
Brugia malayi cyclin-dependent kinase 7 homolog 0.0108 0.0599 0.0555
Echinococcus multilocularis twitchin 0.0048 0.0086 0.0082
Plasmodium vivax calcium-dependent protein kinase, putative 0.0059 0.0181 0.0177
Plasmodium falciparum histone deacetylase 1 0.0063 0.0214 0.0454
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0119 0.0695 0.0695
Echinococcus multilocularis mitogen activated protein kinase 14 0.015 0.0965 0.0962
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0185 0.1264 0.1223
Onchocerca volvulus 0.0143 0.09 0.1112
Echinococcus multilocularis casein kinase i 0.0059 0.0182 0.0179
Echinococcus multilocularis raf serine:threonine protein kinase 0.005 0.0103 0.0099
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0086 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0064 0.0064
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0052 0.0117 0.0071
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0099 0.0524 0.0524
Echinococcus granulosus epidermal growth factor receptor 0.1197 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0046 0.0064 0.0017
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0097 0.0503 0.0499
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0064 0.0047
Schistosoma mansoni cell adhesion molecule 0.0048 0.0086 0.0086
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0048 0.0086 0.0082
Echinococcus granulosus casein kinase I alpha 0.0059 0.0182 0.0179
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0103 0.0556 0.1385
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0215 0.1525 0.1485
Giardia lamblia Kinase, PLK 0.0118 0.0686 0.1576
Loa Loa (eye worm) hypothetical protein 0.0063 0.0212 0.0166
Loa Loa (eye worm) TK/ALK protein kinase 0.0563 0.4528 0.4503
Trichomonas vaginalis AGC family protein kinase 0.0471 0.3729 1
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.1898 0.1898
Trypanosoma brucei rac serine-threonine kinase, putative 0.0049 0.0094 0.013
Echinococcus granulosus tyrosine kinase 0.0083 0.0389 0.0386
Brugia malayi Peroxidasin 0.0049 0.0089 0.0043
Echinococcus multilocularis roundabout 2 0.0151 0.0973 0.097
Echinococcus granulosus aurora kinase A 0.0471 0.3729 0.3727
Echinococcus granulosus Vam6:Vps39 protein 0.0078 0.034 0.0337
Brugia malayi Protein kinase domain containing protein 0.0081 0.0367 0.0322
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0067 0.0243 0.0243
Echinococcus granulosus cyclin dependent kinase 5 0.0109 0.0608 0.0604
Trypanosoma brucei protein kinase, putative 0.0119 0.0695 0.1761
Loa Loa (eye worm) TK/ABL protein kinase 0.0267 0.1969 0.1932
Trichomonas vaginalis CK1 family protein kinase 0.0059 0.0182 0.0368
Brugia malayi Protein kinase domain containing protein 0.0204 0.143 0.139
Schistosoma mansoni protein kinase 0.0173 0.1166 0.1166
Loa Loa (eye worm) hypothetical protein 0.0079 0.0347 0.0302
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.0503 0.0499
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.0686 0.1829
Plasmodium falciparum calcium-dependent protein kinase 3 0.0059 0.0181 0.0365
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0209 0.1474 0.3877
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0082 0.0379 0.0376
Brugia malayi Protein kinase domain containing protein 0.0053 0.0129 0.0083
Trichomonas vaginalis STE family protein kinase 0.0173 0.1162 0.303
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0108 0.0605 0.0561
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0052 0.0118 0.0114
Echinococcus granulosus serine:threonine protein kinase 0.0062 0.0206 0.0203
Brugia malayi protein kinase C II. 0.0061 0.0199 0.0153
Onchocerca volvulus 0.0053 0.0129 0.0155
Loa Loa (eye worm) hypothetical protein 0.0066 0.0236 0.019
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0044 0.0046 0.0043
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0173 0.1162 0.303
Echinococcus granulosus cyclin dependent kinase 0.0109 0.0608 0.0604
Loa Loa (eye worm) hypothetical protein 0.0184 0.1253 0.1212
Loa Loa (eye worm) TK protein kinase 0.0164 0.1087 0.1045
Loa Loa (eye worm) hypothetical protein 0.0124 0.0739 0.0696
Echinococcus multilocularis mitogen activated protein kinase 11 0.015 0.0965 0.0962
Schistosoma mansoni vesicular amine transporter 0.0099 0.0524 0.0524
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0153 0.0986 0.0944
Echinococcus multilocularis c src tyrosine kinase 0.0067 0.0243 0.0239
Loa Loa (eye worm) hypothetical protein 0.01 0.0535 0.0491
Leishmania major protein kinase A catalytic subunit 0.0103 0.0556 0.1385
Echinococcus granulosus protein kinase 0.0082 0.0379 0.0376
Echinococcus granulosus contactin 0.0052 0.0118 0.0114
Echinococcus granulosus serine:threonine protein kinase N2 0.0046 0.0064 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0477 0.0477
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0114 0.0654 0.061
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0477 0.0477
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Echinococcus granulosus TGF-beta receptor type-1 0.0094 0.0483 0.048
Loa Loa (eye worm) hypothetical protein 0.0143 0.09 0.0858
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.143 0.143
Brugia malayi Protein kinase domain containing protein 0.0193 0.1335 0.1294
Brugia malayi Protein kinase domain containing protein 0.0053 0.0129 0.0083
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0052 0.0118 0.0118
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0209 0.1474 0.3877
Trichomonas vaginalis AGC family protein kinase 0.0471 0.3729 1
Brugia malayi Hr1 repeat family protein 0.0046 0.0064 0.0017
Echinococcus granulosus casein kinase I alpha 0.0059 0.0182 0.0179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0118 0.0072
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.0214 0.0454
Echinococcus multilocularis protein kinase shaggy 0.0119 0.0695 0.0692
Entamoeba histolytica protein kinase, putative 0.0204 0.143 0.3823
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.0805 0.0762
Brugia malayi Immunoglobulin I-set domain containing protein 0.0768 0.6298 0.628
Echinococcus granulosus protein tyrosine kinase 0.0295 0.2213 0.221
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0097 0.0503 0.0499
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0145 0.0917 0.2449
Schistosoma mansoni tyrosine kinase 0.065 0.5275 0.5275
Plasmodium falciparum protein kinase 5 0.0109 0.0608 0.1524
Echinococcus multilocularis cyclin dependent kinase 1 0.0109 0.0608 0.0604
Echinococcus multilocularis lachesin 0.0048 0.0086 0.0082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0086 0.0039
Echinococcus granulosus c src tyrosine kinase 0.0067 0.0243 0.0239
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0103 0.0556 0.0553
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0193 0.1335 0.1294
Brugia malayi SH2 domain containing protein 0.0053 0.0129 0.0083
Giardia lamblia Kinase, AGC PKA 0.0103 0.0556 0.1217
Brugia malayi serine/threonine kinase 12 0.0471 0.3729 0.37
Giardia lamblia Histone deacetylase 0.0063 0.0214 0.0268
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0039
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0055 0.0145 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0046 0.0046
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0103 0.0556 0.1481
Brugia malayi cell division control protein 2 homolog 0.0109 0.0608 0.0564
Brugia malayi histone deacetylase 1 (HD1) 0.0063 0.0214 0.0168
Echinococcus multilocularis serine:threonine protein kinase 0.0062 0.0206 0.0203
Entamoeba histolytica PH domain containing protein kinase, putative 0.0106 0.0587 0.1557
Loa Loa (eye worm) hypothetical protein 0.01 0.0527 0.0483
Loa Loa (eye worm) hypothetical protein 0.0049 0.0089 0.0043
Echinococcus granulosus tyrosine protein kinase Src64B 0.0097 0.0503 0.0499
Schistosoma mansoni tyrosine kinase 0.0517 0.4129 0.4129
Echinococcus multilocularis casein kinase I delta 0.0059 0.0182 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0078 0.034 0.0295
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0078 0.034 0.034
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0052 0.0118 0.0114
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0109 0.0608 0.1524
Loa Loa (eye worm) hypothetical protein 0.0099 0.0524 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0199 0.0199
Echinococcus multilocularis cyclin dependent kinase 9 0.0067 0.0246 0.0243
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.0214 0.0454
Echinococcus multilocularis cyclin dependent kinase 1 0.0109 0.0608 0.0604
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0608 0.1524
Trypanosoma cruzi casein kinase, putative 0.0059 0.0182 0.0476
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0039
Trichomonas vaginalis STE family protein kinase 0.0173 0.1162 0.303
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0099 0.052 0.1145
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0086 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Entamoeba histolytica histone deacetylase, putative 0.0063 0.0214 0.0554
Echinococcus granulosus lachesin 0.0048 0.0086 0.0082
Onchocerca volvulus 0.0053 0.0129 0.0155
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0059 0.0181 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0031 0.0065
Trichomonas vaginalis aldehyde oxidase, putative 0.0209 0.1474 0.3877
Echinococcus multilocularis tyrosine protein kinase Srms 0.0083 0.0389 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0686 0.1737
Mycobacterium ulcerans hypothetical protein 0.0101 0.0543 0.1197
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0059 0.0181 0.0365
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0119 0.0695 0.0692
Schistosoma mansoni protein kinase 0.0471 0.3729 0.3729
Brugia malayi Protein kinase domain containing protein 0.0049 0.0094 0.0048
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0127 0.0761 0.1785
Brugia malayi serine/threonine-protein kinase plk-2 0.0118 0.0686 0.0643
Schistosoma mansoni cell adhesion molecule 0.0123 0.0733 0.0733
Trichomonas vaginalis STE family protein kinase 0.0127 0.0761 0.1941
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0052 0.0118 0.0072
Plasmodium falciparum calcium-dependent protein kinase 4 0.0059 0.0181 0.0365
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0103 0.0556 0.1385
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.0503 0.0499
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0132 0.081 0.0807
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0059 0.0182 0.0136
Echinococcus multilocularis tyrosine kinase 0.0053 0.0129 0.0126
Echinococcus granulosus twitchin 0.0147 0.0941 0.0938
Echinococcus granulosus peroxidasin 0.0049 0.0089 0.0086
Echinococcus multilocularis cyclin dependent kinase 7 0.01 0.0529 0.0526
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0132 0.081 0.0807
Leishmania major protein kinase, putative 0.0059 0.0181 0.0365
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0246 0.0642
Entamoeba histolytica serine/threonine protein kinase, putative 0.0118 0.0686 0.1823
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1009 0.1009
Entamoeba histolytica tyrosin kinase, putative 0.0042 0.0031 0.0065
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0552 0.4435 1
Schistosoma mansoni protein kinase 0.0094 0.0483 0.0483
Echinococcus granulosus dual specificity protein kinase clk2 0.0145 0.0917 0.0914
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0052 0.0118 0.0114
Loa Loa (eye worm) AGC/PKA protein kinase 0.0103 0.0556 0.0512
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0119 0.0695 0.1761
Loa Loa (eye worm) hypothetical protein 0.0205 0.1441 0.1401
Loa Loa (eye worm) histone deacetylase 1 0.0063 0.0214 0.0168
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0046 0.0064 0.0017
Echinococcus granulosus Immunoglobulin 0.0099 0.0524 0.0521
Loa Loa (eye worm) hypothetical protein 0.014 0.0873 0.0831
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0327 0.2487 0.2452
Brugia malayi bone morphogenetic protein type 1 receptor 0.0108 0.0605 0.0561
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0215 0.1525 0.1522
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0137 0.0847 0.0844
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0053 0.0129 0.0126
Brugia malayi SH2 domain containing protein 0.0053 0.0129 0.0083
Plasmodium falciparum protein kinase, putative 0.0055 0.0145 0.0268
Schistosoma mansoni protein kinase 0.0327 0.2487 0.2487
Plasmodium vivax glycogen synthase kinase 3, putative 0.0119 0.0695 0.1601
Giardia lamblia Kinase, CMGC CLK 0.0145 0.0917 0.2215
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0118 0.0072
Echinococcus granulosus tyrosine protein kinase ABL1 0.0267 0.1969 0.1966
Loa Loa (eye worm) hypothetical protein 0.0147 0.0941 0.0899
Trypanosoma cruzi aurora B kinase, putative 0.0471 0.3729 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0061 0.0199 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0499 0.3978 0.395
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0062 0.0208 0.0204
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0094 0.0483 0.048
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0053 0.0129 0.0327
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0173 0.1162 0.1121
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0082 0.0379 0.0376
Trypanosoma cruzi cdc2-related kinase 3 0.0109 0.0608 0.1619
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0048 0.0086 0.0086
Giardia lamblia Kinase, AGC AKT 0.0107 0.0592 0.1317
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0471 0.3729 0.3727
Echinococcus granulosus TGF beta receptor type 1 0.0094 0.0483 0.048
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0048 0.0086 0.0039
Schistosoma mansoni protein kinase 0.0055 0.0145 0.0145
Loa Loa (eye worm) AUR protein kinase 0.0471 0.3729 0.37
Brugia malayi protein C17H12.11 0.0063 0.0212 0.0166
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0078 0.034 0.0337
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.0695 0.1848
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0246 0.0246
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0153 0.0986 0.0944
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0078 0.034 0.0901
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Brugia malayi serine/threonine-protein kinase PAK 7 0.0209 0.1473 0.1434
Entamoeba histolytica protein kinase, putative 0.0471 0.3729 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0556 0.0512
Brugia malayi Tyrosine-protein kinase abl-1 0.0148 0.0946 0.0904
Echinococcus multilocularis cyclin dependent kinase 19 0.0155 0.1009 0.1006
Trichomonas vaginalis CK1 family protein kinase 0.0059 0.0182 0.0368
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0046 0.0064 0.0017
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0084 0.0389 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0086 0.0086
Entamoeba histolytica protein kinase, putative 0.0046 0.0064 0.0152
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0103 0.0556 0.0553
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0059 0.0181 0.0177
Entamoeba histolytica casein kinase 1, putative 0.0059 0.0182 0.0469
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0046 0.0046
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0327 0.2487 0.2485
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.0208 0.0162
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.016
Onchocerca volvulus 0.03 0.2261 0.2803
Schistosoma mansoni titin 0.0048 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0078 0.034 0.034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.0503 0.0499
Echinococcus multilocularis tyrosine protein kinase otk 0.0048 0.0086 0.0082
Echinococcus multilocularis hemicentin 1 0.0048 0.0086 0.0082
Trichomonas vaginalis STE family protein kinase 0.0173 0.1162 0.303
Echinococcus multilocularis peroxidasin 0.0049 0.0089 0.0086
Onchocerca volvulus 0.0082 0.0377 0.0463
Leishmania major protein kinase A catalytic subunit isoform 2 0.0103 0.0556 0.1385
Onchocerca volvulus 0.0119 0.0695 0.0858
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.0214 0.0454
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0529 0.0529
Giardia lamblia Kinase, CMGC GSK 0.0119 0.0695 0.1601
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0185 0.1264 0.1261
Echinococcus multilocularis dual specificity 0.0204 0.143 0.1427
Echinococcus granulosus titin 0.0052 0.0118 0.0114
Loa Loa (eye worm) hypothetical protein 0.0088 0.043 0.0386
Echinococcus multilocularis Immunoglobulin 0.0099 0.0524 0.0521
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0059 0.0181 0.0135
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.015 0.0965 0.2495
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0185 0.1264 0.1223
Leishmania major protein kinase A catalytic subunit isoform 1 0.0103 0.0556 0.1385
Echinococcus granulosus tyrosine protein kinase HCK 0.0065 0.0228 0.0225
Schistosoma mansoni tyrosine kinase 0.0067 0.0243 0.0243
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0099 0.0524 0.048
Entamoeba histolytica protein kinase domain containing protein 0.0471 0.3729 1
Schistosoma mansoni serine/threonine protein kinase 0.0321 0.2438 0.2438
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0145 0.0917 0.2363
Loa Loa (eye worm) hypothetical protein 0.0116 0.0671 0.0628
Echinococcus multilocularis hemicentin 1 0.0048 0.0086 0.0082
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0471 0.3729 1
Echinococcus multilocularis neuroglian 0.0052 0.0118 0.0114
Schistosoma mansoni kinase 0.007 0.0272 0.0272
Leishmania major protein kinase, putative 0.0145 0.0917 0.2363
Onchocerca volvulus 0.0321 0.2438 0.3023
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0059 0.0181 0.0177
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0768 0.6298 0.628
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0267 0.1969 0.1966
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0139 0.0872 0.0829
Plasmodium falciparum calcium-dependent protein kinase 1 0.0059 0.0181 0.0365
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0118 0.0686 0.0683
Schistosoma mansoni tyrosine kinase 0.0051 0.0107 0.0107
Giardia lamblia Kinase, CK1 Casein kinase 0.0059 0.0182 0.0181
Echinococcus granulosus cyclin dependent kinase 1 0.0109 0.0608 0.0604
Loa Loa (eye worm) hypothetical protein 0.0143 0.09 0.0858
Echinococcus multilocularis aurora kinase A 0.0471 0.3729 0.3727
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0046 0.0064 0.006
Echinococcus multilocularis 0.0361 0.2782 0.2779
Schistosoma mansoni neuroglian 0.0052 0.0118 0.0118
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0059 0.0181 0.0177
Onchocerca volvulus 0.0053 0.0129 0.0155
Schistosoma mansoni rap gtpase-activating protein 0.0078 0.034 0.034
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0046 0.0046
Entamoeba histolytica protein kinase, putative 0.0204 0.143 0.3823
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0145 0.0268
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0103 0.0556 0.0512
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.0129 0.0083
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0097 0.0503 0.0499
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0173 0.1166 0.1163
Echinococcus multilocularis serine:threonine protein kinase N2 0.0046 0.0064 0.006
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0317 0.0313
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0145 0.0917 0.0874
Brugia malayi serine/threonine-protein kinase 6 0.0471 0.3729 0.37
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0204 0.1426 0.1423
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0103 0.0556 0.1385
Echinococcus granulosus epidermal growth factor receptor 0.0685 0.5574 0.5573
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0078 0.034 0.0901
Loa Loa (eye worm) CAMK protein kinase 0.0052 0.0118 0.0072
Echinococcus granulosus tyrosine protein kinase Btk29A 0.01 0.0535 0.0532
Loa Loa (eye worm) hypothetical protein 0.0074 0.0306 0.026
Brugia malayi Protein kinase domain containing protein 0.0955 0.791 0.79
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0098 0.0518 0.0514
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0119 0.0695 0.0652
Echinococcus multilocularis insulin receptor 0.0517 0.4129 0.4127
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0215 0.1525 0.1522
Onchocerca volvulus 0.0079 0.0347 0.0425
Brugia malayi Protein kinase domain containing protein 0.0145 0.0917 0.0874
Echinococcus granulosus defective proboscis extension response 0.0099 0.0524 0.0521
Trichomonas vaginalis AGC family protein kinase 0.0471 0.3729 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0258 0.1898 0.1895
Echinococcus multilocularis 0.0124 0.0739 0.0736
Loa Loa (eye worm) hypothetical protein 0.0171 0.1142 0.11
Giardia lamblia Aurora kinase 0.0471 0.3729 1
Echinococcus multilocularis rho associated protein kinase 0.0321 0.2438 0.2435
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0071 0.0278 0.0599
Schistosoma mansoni tyrosine kinase 0.065 0.5275 0.5275
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0132 0.081 0.0767
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0059 0.0181 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0117 0.0117
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0143 0.0901 0.0898
Brugia malayi cyclin-dependent kinase 9 0.0067 0.0246 0.0201
Schistosoma mansoni cell adhesion molecule 0.0052 0.0118 0.0118
Echinococcus multilocularis protein kinase c epsilon type 0.0061 0.0199 0.0195
Schistosoma mansoni protein kinase 0.016 0.1051 0.1051
Trypanosoma cruzi casein kinase, putative 0.0059 0.0182 0.0476
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0073 0.0295 0.025
Brugia malayi Protein kinase domain containing protein 0.0185 0.1264 0.1223
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0103 0.0103
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0471 0.3729 1
Entamoeba histolytica protein kinase, putative 0.004 0.0016 0.0023
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0119 0.0695 0.0652
Schistosoma mansoni tyrosine kinase 0.0248 0.1808 0.1808
Echinococcus granulosus dual specificity 0.0204 0.143 0.1427
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0686 0.0686
Echinococcus granulosus fibroblast growth factor receptor 4 0.0137 0.0847 0.0844
Echinococcus granulosus cyclin dependent kinase 9 0.0067 0.0246 0.0243
Loa Loa (eye worm) hypothetical protein 0.0103 0.0556 0.0512
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0078 0.034 0.0798
Entamoeba histolytica protein kinase, putative 0.0065 0.0228 0.0593
Echinococcus multilocularis death associated protein kinase 1 0.0859 0.7079 0.7078
Entamoeba histolytica protein kinase, putative 0.0471 0.3729 1
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0046 0.0046
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.0214 0.0454
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0044 0.0046 0.0112
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.015 0.0965 0.2579
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.0104 0.0101
Echinococcus multilocularis Immunoglobulin 0.0099 0.0524 0.0521
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0143 0.0901 0.0898
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0145 0.0917 0.2363
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0685 0.5574 0.5573
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0182 0.0182
Onchocerca volvulus Serine\/threonine kinase homolog 0.0118 0.0686 0.0847
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0118 0.0118
Schistosoma mansoni tyrosine kinase 0.0192 0.1326 0.1326
Brugia malayi casein kinase 1, delta 0.0059 0.0182 0.0136
Echinococcus granulosus histone deacetylase 3 0.0063 0.0214 0.021
Loa Loa (eye worm) TK protein kinase 0.0065 0.0228 0.0182
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0173 0.1166 0.1163
Onchocerca volvulus 0.0052 0.0118 0.0141
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Echinococcus granulosus activin receptor type 0.0432 0.3397 0.3395
Echinococcus granulosus rho-associated protein kinase 1 0.0321 0.2438 0.2435
Echinococcus multilocularis cyclin dependent kinase 0.0109 0.0608 0.0604
Brugia malayi Stress-activated protein kinase jnk-1 0.0258 0.1898 0.186
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0145 0.0917 0.2449
Brugia malayi Histone deacetylase 1 0.0063 0.0214 0.0168
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.0214 0.0454
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0059 0.0181 0.0177
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0097 0.0503 0.0499
Loa Loa (eye worm) SRC-1 0.0097 0.0503 0.0458
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.1525 0.1525
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0094 0.0477 0.0474
Loa Loa (eye worm) AUR protein kinase 0.0471 0.3729 0.37
Leishmania major histone deacetylase, putative 0.0063 0.0214 0.0454
Brugia malayi Protein kinase domain containing protein 0.0109 0.0608 0.0564
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0204 0.143 0.3757
Brugia malayi Protein kinase domain containing protein 0.0563 0.453 0.4504
Onchocerca volvulus 0.0053 0.0129 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0917 0.0917
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0094 0.0477 0.0474
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0139 0.0872 0.0869
Plasmodium falciparum casein kinase 1 0.0059 0.0182 0.0368
Mycobacterium ulcerans hypothetical protein 0.0101 0.0543 0.1197
Brugia malayi hypothetical protein 0.0103 0.0556 0.0512
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0521 0.4161 0.4159
Loa Loa (eye worm) AGC/NDR protein kinase 0.0046 0.0064 0.0017
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0046 0.0064 0.0017
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0173 0.1162 0.1121
Entamoeba histolytica protein kinase domain containing protein 0.0204 0.143 0.3823
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Toxoplasma gondii AGC kinase 0.0046 0.0064 0.0047
Loa Loa (eye worm) hypothetical protein 0.0147 0.0941 0.0899
Echinococcus granulosus tyrosine protein kinase Srms 0.0053 0.0129 0.0126
Brugia malayi Immunoglobulin I-set domain containing protein 0.0103 0.0556 0.0512
Loa Loa (eye worm) AUR protein kinase 0.0471 0.3729 0.37
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.015 0.0965 0.2495
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0145 0.0917 0.2449
Trypanosoma cruzi casein kinase, putative 0.0059 0.0182 0.0476
Echinococcus multilocularis transfer RNA-Thr 0.0205 0.1441 0.1438
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0064 0.0047
Echinococcus multilocularis calcium activated potassium channel 0.0052 0.0117 0.0114
Schistosoma mansoni tyrosine kinase 0.0053 0.0129 0.0129
Onchocerca volvulus 0.0059 0.0182 0.022
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0094 0.0477 0.0474
Echinococcus multilocularis tyrosine protein kinase Blk 0.0083 0.0389 0.0386
Echinococcus multilocularis casein kinase I delta 0.0059 0.0182 0.0179
Loa Loa (eye worm) hypothetical protein 0.0103 0.0556 0.0512
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0078 0.034 0.0337
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0608 0.1524
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0103 0.0556 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.081 0.081
Brugia malayi serine/threonine protein kinase 6 0.0471 0.3729 0.37
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0117 0.0117
Entamoeba histolytica p21-activated kinase 0.004 0.0016 0.0023
Echinococcus granulosus hemicentin 1 0.0048 0.0086 0.0082
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0552 0.4435 0.5
Brugia malayi hypothetical protein 0.0053 0.0129 0.0083
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0099 0.0524 0.0524
Echinococcus multilocularis protein tyrosine kinase 0.0295 0.2213 0.221
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0543 0.1197
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0059 0.0182 0.0476
Loa Loa (eye worm) AGC/PKN protein kinase 0.0046 0.0064 0.0017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.0503 0.0499
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0471 0.3729 1
Entamoeba histolytica protein kinase, putative 0.0049 0.0094 0.0234
Entamoeba histolytica protein kinase, putative 0.004 0.0016 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0686 0.1737
Echinococcus multilocularis dual specificity protein kinase clk2 0.0145 0.0917 0.0914
Entamoeba histolytica hypothetical protein 0.0204 0.143 0.3823
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.5824 0.5824
Loa Loa (eye worm) AGC/AKT protein kinase 0.0049 0.0094 0.0048
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0097 0.0503 0.0499
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0163 0.0117
Plasmodium falciparum protein serine/threonine kinase-1 0.0145 0.0917 0.2363
Schistosoma mansoni tyrosine kinase 0.065 0.5275 0.5275
Loa Loa (eye worm) IKK protein kinase 0.0972 0.8053 0.8044
Trypanosoma cruzi histone deacetylase 1, putative 0.0063 0.0214 0.0561
Echinococcus multilocularis tyrosine protein kinase HCK 0.0065 0.0228 0.0225
Echinococcus multilocularis serine:threonine protein kinase 38 0.0046 0.0064 0.006
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0046 0.0064 0.006
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0134 0.0238
Brugia malayi Protein kinase domain containing protein 0.0053 0.0129 0.0083
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0114 0.0652 0.0649
Giardia lamblia Kinase, NEK 0.0127 0.0761 0.1785
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.1335 0.1335
Schistosoma mansoni protein kinase C mu 0.0099 0.0524 0.0524
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0114 0.0654 0.061
Schistosoma mansoni tyrosine kinase 0.0097 0.0503 0.0503
Schistosoma mansoni tyrosine kinase 0.0685 0.5574 0.5574
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0986 0.0986
Echinococcus multilocularis activated cdc42 kinase 1 0.0205 0.1441 0.1438
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0119 0.0695 0.1854
Brugia malayi Cam kinase protein 1 0.0059 0.0181 0.0135
Brugia malayi Protein kinase domain containing protein 0.0517 0.4129 0.4101
Echinococcus multilocularis TGF beta receptor type 1 0.0094 0.0483 0.048
Plasmodium falciparum serine/threonine protein kinase, putative 0.0471 0.3729 1
Echinococcus granulosus roundabout 2 0.0151 0.0973 0.097
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0114 0.0652 0.0649
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0059 0.0181 0.0177
Brugia malayi Temporarily assigned gene name protein 59 0.0078 0.034 0.0295
Echinococcus multilocularis serine threonine protein kinase 0.0046 0.0064 0.006
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0111 0.0623 0.1565
Schistosoma mansoni tyrosine kinase 0.0295 0.2213 0.2213
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0059 0.0182 0.0136
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Giardia lamblia Kinase, NEK 0.0127 0.0761 0.1785
Loa Loa (eye worm) TK/FAK protein kinase 0.0298 0.224 0.2203
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0097 0.0503 0.0499
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Entamoeba histolytica protein kinase, putative 0.0059 0.0181 0.0466
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0084 0.0389 0.0344
Loa Loa (eye worm) hypothetical protein 0.0052 0.0118 0.0072
Echinococcus granulosus tyrosine protein kinase Lyn 0.0117 0.068 0.0677
Schistosoma mansoni tyrosine kinase 0.0517 0.4129 0.4129
Toxoplasma gondii histone deacetylase HDAC3 0.0063 0.0214 0.0454
Echinococcus granulosus protein kinase shaggy 0.0119 0.0695 0.0692
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0173 0.1162 0.303
Schistosoma mansoni kinase 0.0067 0.0246 0.0246
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0099 0.0524 0.048
Entamoeba histolytica protein kinase, putative 0.0049 0.0094 0.0234
Giardia lamblia Kinase, STE STE20 0.0173 0.1162 0.2894
Echinococcus granulosus activated cdc42 kinase 1 0.0205 0.1441 0.1438
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0094 0.013
Brugia malayi protein unc-22 0.0052 0.0118 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0695 0.1761
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0083 0.0389 0.0386
Echinococcus granulosus mitogen activated protein kinase 14 0.015 0.0965 0.0962
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0059 0.0181 0.0365
Echinococcus granulosus neuroglian 0.0052 0.0118 0.0114
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0052 0.0118 0.0114
Echinococcus granulosus cyclin dependent kinase 19 0.0155 0.1009 0.1006
Echinococcus multilocularis histone deacetylase 3 0.0063 0.0214 0.021
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0103 0.0556 0.0553
Echinococcus multilocularis 0.0082 0.0379 0.0376
Brugia malayi C1-like domain containing protein 0.0099 0.0524 0.048
Loa Loa (eye worm) hypothetical protein 0.0099 0.0524 0.048
Brugia malayi Protein kinase domain containing protein 0.0205 0.1441 0.1401
Echinococcus granulosus roundabout 2 0.0052 0.0118 0.0114
Brugia malayi Protein kinase domain containing protein 0.0327 0.2487 0.2452
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0048 0.0086 0.0039
Echinococcus granulosus calcium activated potassium channel 0.0052 0.0117 0.0114
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0109 0.0608 0.1524
Echinococcus granulosus microtubule associated protein 2 0.0713 0.5824 0.5823
Toxoplasma gondii aurora kinase 0.0471 0.3729 1
Brugia malayi hypothetical protein 0.0063 0.0212 0.0166
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0053 0.0129 0.0126
Onchocerca volvulus 0.0614 0.4966 0.6164
Toxoplasma gondii AGC kinase 0.0103 0.0556 0.1385
Treponema pallidum licC protein (licC) 0.0101 0.0543 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.0503 0.0499
Brugia malayi Protein kinase domain containing protein 0.0046 0.0064 0.0017
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0127 0.0761 0.1941
Schistosoma mansoni protein kinase 0.0108 0.0605 0.0605
Leishmania major casein kinase, putative 0.0059 0.0182 0.0368
Loa Loa (eye worm) hypothetical protein 0.0184 0.1253 0.1212
Loa Loa (eye worm) AGC/PKA protein kinase 0.0103 0.0556 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0686 0.1737
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0101 0.0543 0.1348
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0556 0.0556
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0185 0.1264 0.1564
Echinococcus multilocularis tyrosine protein kinase shark 0.0053 0.0129 0.0126
Trypanosoma brucei casein kinase I, isoform 2 0.0059 0.0182 0.0368
Echinococcus multilocularis serine:threonine protein kinase 0.0062 0.0206 0.0203
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0103 0.0556 0.1481
Echinococcus granulosus tyrosine protein kinase otk 0.0048 0.0086 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0917 0.2363
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.01 0.0529 0.0485
Loa Loa (eye worm) histone deacetylase 3 0.0063 0.0214 0.0168
Schistosoma mansoni cell adhesion molecule 0.0052 0.0118 0.0118
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0046 0.0064 0.006
Brugia malayi Protein kinase domain containing protein 0.0298 0.224 0.2203
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0052 0.0118 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0261 0.0581
Schistosoma mansoni nephrin 0.0131 0.0796 0.0796
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0261 0.0581
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0652 0.0652
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0103 0.0556 0.1481
Entamoeba histolytica serine/threonine protein kinase, putative 0.0044 0.0046 0.0105
Entamoeba histolytica protein kinase, putative 0.0059 0.0181 0.0466
Giardia lamblia Kinase, CMGC CDK 0.0109 0.0608 0.1359
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0071 0.0278 0.0599
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0117 0.0192
Entamoeba histolytica PH domain containing protein kinase, putative 0.0106 0.0587 0.1557
Echinococcus granulosus roundabout 2 0.0052 0.0118 0.0114
Schistosoma mansoni tyrosine kinase 0.1197 1 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0059 0.0181 0.0365
Brugia malayi Serine/threonine-protein kinase SULU 0.0215 0.1525 0.1485
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0101 0.0543 0.1197
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0471 0.3729 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0059 0.0181 0.0135
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0193 0.1334 0.1331
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0109 0.0608 0.0564
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0215 0.1525 0.1522
Brugia malayi Prion-like- 0.0048 0.0086 0.0039
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0103 0.0556 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0686 0.1737
Echinococcus multilocularis tyrosine protein kinase Abl 0.0148 0.0946 0.0943
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0463 0.3661 0.3659
Schistosoma mansoni tyrosine kinase 0.01 0.0535 0.0535
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0059 0.0181 0.0135
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0099 0.0524 0.0521
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.015 0.0965 0.0923
Brugia malayi Protein kinase domain containing protein 0.0084 0.0389 0.0344
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.0695 0.1848
Plasmodium vivax histone deacetylase 1, putative 0.0063 0.0214 0.0268
Echinococcus granulosus protein kinase C gamma type 0.0046 0.0064 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0686 0.1737
Brugia malayi casein kinase I 0.0059 0.0182 0.0136
Echinococcus multilocularis mitogen activated protein kinase 11 0.015 0.0965 0.0962
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0067 0.0246 0.0201
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0064 0.0064
Schistosoma mansoni vam6/vps39 related 0.0078 0.034 0.034

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 24.5 nM Inhibition of xanthine oxidase (unknown origin) assessed as reduction in uric acid formation preincubated for 5 mins followed by addition of xanthine substrate measured every minute up to 8 mins LITERATURE. 28340987
IC50 (binding) = 1540 nM Time-Resolved Fluorescence Assay BINDINGDB. No reference
IC50 (binding) = 1.5 uM Inhibition of EGFR cytoplasmic domain (amino acids 645 to 1186) (unknown origin) expressed in Sf9 cells assessed as reduction in enzyme autophosphorylation by DELFIA time resolved fluorometry ChEMBL. 23245570
IC50 (functional) = 5.67 uM Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay ChEMBL. 23245570
Inhibition (binding) = 12.4 % Inhibition of URAT1 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]-uric acid uptake at 100 uM preincubated for 30 mins followed by [14C]-uric acid addition by liquid scintillation counting analysis relative to control LITERATURE. 28340987

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23245570

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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