Detailed information for compound 174537

Basic information

Technical information
  • TDR Targets ID: 174537
  • Name: 3-[[3-bromo-2-[2-(2H-tetrazol-5-yl)phenyl]-1- benzofuran-5-yl]methyl]-5-cyclopropyl-N,2-die thylimidazole-4-carboxamide
  • MW: 560.445 | Formula: C27H26BrN7O2
  • H donors: 2 H acceptors: 5 LogP: 4.96 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCNC(=O)c1c(nc(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1c1n[nH]nn1)CC)C1CC1
  • InChi: 1S/C27H26BrN7O2/c1-3-21-30-23(16-10-11-16)24(27(36)29-4-2)35(21)14-15-9-12-20-19(13-15)22(28)25(37-20)17-7-5-6-8-18(17)26-31-33-34-32-26/h5-9,12-13,16H,3-4,10-11,14H2,1-2H3,(H,29,36)(H,31,32,33,34)
  • InChiKey: HTTNJKRAAFIWRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[[3-bromo-2-[2-(2H-tetrazol-5-yl)phenyl]benzofuran-5-yl]methyl]-5-cyclopropyl-N,2-diethyl-imidazole-4-carboxamide
  • 3-[[3-bromo-2-[2-(2H-tetrazol-5-yl)phenyl]-5-benzofuranyl]methyl]-5-cyclopropyl-N,2-diethyl-4-imidazolecarboxamide
  • 3-[[3-bromo-2-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]-1-benzofuran-5-yl]methyl]-5-cyclopropyl-N,2-diethyl-imidazole-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II receptor   359 aa 346 aa 18.2 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II receptor   359 aa 295 aa 27.5 %
Brugia malayi ORL1-like opioid receptor Angiotensin II receptor   359 aa 314 aa 20.1 %
Echinococcus granulosus allatostatin A receptor Angiotensin II receptor   359 aa 348 aa 25.9 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II receptor   359 aa 327 aa 24.2 %
Onchocerca volvulus Angiotensin II receptor   359 aa 303 aa 25.1 %
Schistosoma mansoni adenoreceptor Angiotensin II receptor   359 aa 329 aa 24.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II receptor   359 aa 334 aa 23.7 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II receptor   359 aa 311 aa 23.5 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II receptor   359 aa 348 aa 25.9 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II receptor   359 aa 336 aa 22.3 %
Brugia malayi GnHR receptor homolog Angiotensin II receptor   359 aa 364 aa 20.9 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II receptor   359 aa 406 aa 20.0 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II receptor   359 aa 351 aa 21.9 %
Onchocerca volvulus Angiotensin II receptor   359 aa 294 aa 23.8 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II receptor   359 aa 308 aa 22.4 %
Onchocerca volvulus Angiotensin II receptor   359 aa 386 aa 24.9 %
Echinococcus granulosus neuropeptide receptor Angiotensin II receptor   359 aa 316 aa 25.0 %
Schistosoma mansoni opsin-like receptor Angiotensin II receptor   359 aa 299 aa 25.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II receptor   359 aa 314 aa 26.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II receptor   359 aa 337 aa 24.0 %
Onchocerca volvulus Angiotensin II receptor   359 aa 395 aa 23.0 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II receptor   359 aa 316 aa 25.3 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Angiotensin II receptor   359 aa 351 aa 21.9 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor   359 aa 330 aa 26.7 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II receptor   359 aa 303 aa 22.4 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II receptor   359 aa 352 aa 20.5 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II receptor   359 aa 356 aa 24.2 %
Onchocerca volvulus Angiotensin II receptor   359 aa 312 aa 19.2 %
Onchocerca volvulus Angiotensin II receptor   359 aa 314 aa 25.8 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II receptor   359 aa 407 aa 19.4 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor   359 aa 335 aa 23.3 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II receptor   359 aa 303 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0061 0.0245 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0059 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0209 0.0263
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Brugia malayi SWIB/MDM2 domain containing protein 0.1569 0.718 1
Plasmodium vivax RING zinc finger protein, putative 0.0028 0.0097 0.0084
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1569 0.718 1
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0131
Schistosoma mansoni hypothetical protein 0.0033 0.0116 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0209 0.0263
Schistosoma mansoni TRABID protein (C64 family) 0.0558 0.2532 0.3508
Loa Loa (eye worm) transcription factor SMAD2 0.0388 0.1751 0.2438
Toxoplasma gondii ran binding protein 0.0558 0.2532 0.3525
Onchocerca volvulus Cell death protein 3 homolog 0.002 0.0058 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0558 0.2532 0.3508
Brugia malayi RING finger protein 20 0.0028 0.0097 0.0106
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0021 0.0065 0.0162
Entamoeba histolytica hypothetical protein 0.0028 0.0097 0.3401
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0558 0.2532 0.3508
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0088 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Echinococcus multilocularis apoptotic protease activating factor 1 0.002 0.0058 0.0046
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0558 0.2532 0.3508
Loa Loa (eye worm) MH2 domain-containing protein 0.0388 0.1751 0.2438
Echinococcus multilocularis 0.0028 0.0097 0.0094
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0028 0.0097 0.0135
Brugia malayi Calcitonin receptor-like protein seb-1 0.0261 0.1165 0.1599
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0028 0.0097 0.0084
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0346 0.0402
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0088 0.0083
Loa Loa (eye worm) hypothetical protein 0.0178 0.0786 0.1093
Echinococcus multilocularis ring finger protein 113a 0.0028 0.0097 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0209 0.0263
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0558 0.2532 0.3508
Onchocerca volvulus 0.0028 0.0097 0.0106
Echinococcus multilocularis GPCR, family 2 0.0083 0.0346 0.0402
Schistosoma mansoni cpg binding protein 0.0018 0.0051 0.0043
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0013 0.0024 0.0004
Schistosoma mansoni caspase-7 (C14 family) 0.002 0.0058 0.0052
Brugia malayi hypothetical protein 0.002 0.0058 0.0052
Brugia malayi B-box zinc finger family protein 0.0028 0.0097 0.0106
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0209 0.0263
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0147 0.0176
Trichomonas vaginalis ion channel nompc, putative 0.0028 0.0097 0.0135
Schistosoma mansoni ring finger protein 151 0.0028 0.0097 0.0106
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Schistosoma mansoni hypothetical protein 0.1569 0.718 1
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0044 0.0167 0.0571
Trichomonas vaginalis hypothetical protein 0.0028 0.0097 0.0135
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0558 0.2532 0.3494
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0209 0.0233
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0049
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1569 0.718 1
Toxoplasma gondii hypothetical protein 0.0028 0.0097 0.0131
Echinococcus multilocularis caax prenyl protease 1 0.0044 0.0167 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0028 0.0097 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0558 0.2532 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Trypanosoma cruzi target of rapamycin kinase 3 0.003 0.0103 0.0317
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0209 0.0263
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Loa Loa (eye worm) phosphatidylinositol 3 0.0013 0.0024 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Echinococcus granulosus GPCR family 2 0.0083 0.0346 0.0402
Loa Loa (eye worm) phosphatidylinositol 3 0.0037 0.0139 0.0191
Onchocerca volvulus 0.0021 0.0061 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0103 0.0144
Brugia malayi MH2 domain containing protein 0.0388 0.1751 0.2418
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0097 0.029
Onchocerca volvulus 0.1569 0.718 1
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0028 0.0097 0.0094
Schistosoma mansoni cellular tumor antigen P53 0.0259 0.1158 0.1589
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0068 0.0095
Echinococcus multilocularis cpg binding protein 0.002 0.0056 0.0044
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0028 0.0097 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0059 0.0083
Brugia malayi hypothetical protein 0.0037 0.0137 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0082 0.0114
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Brugia malayi hypothetical protein 0.0024 0.0077 0.0079
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0028 0.0097 0.0084
Echinococcus multilocularis smad 0.0026 0.0088 0.0083
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Loa Loa (eye worm) brahma associated protein 0.1569 0.718 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Plasmodium vivax trophozoite exported protein 1, putative 0.0028 0.0097 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0059 0.0083
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0139 0.0193
Loa Loa (eye worm) hypothetical protein 0.0259 0.1158 0.1612
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Onchocerca volvulus 0.0018 0.0051 0.0043
Onchocerca volvulus 0.002 0.0058 0.0052
Loa Loa (eye worm) hypothetical protein 0.0558 0.2532 0.3526
Schistosoma mansoni rnf5 0.0028 0.0097 0.0106
Toxoplasma gondii hypothetical protein 0.0028 0.0097 0.0131
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0558 0.2532 0.3508
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0061 0.0181
Echinococcus multilocularis SWI:SNF matrix associated 0.1569 0.718 0.885
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1569 0.718 1
Trypanosoma brucei DNA repair protein, putative 0.0028 0.0097 0.029
Onchocerca volvulus 0.0028 0.0097 0.0106
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0209 0.0289
Echinococcus multilocularis ring finger protein 170 0.0028 0.0097 0.0094
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0558 0.2532 1
Onchocerca volvulus RING finger protein 141 homolog 0.0028 0.0097 0.0106
Trypanosoma brucei ring finger containing protein 0.0028 0.0097 0.029
Trichomonas vaginalis ankyrin, putative 0.0028 0.0097 0.0135
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0061 0.0545
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0061 0.0245 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0131
Mycobacterium ulcerans hypothetical protein 0.0021 0.0061 0.0545
Schistosoma mansoni zinc finger protein 0.0558 0.2532 0.3508
Plasmodium falciparum trophozoite exported protein 1 0.0028 0.0097 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0113 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0033 0.0045
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0346 0.048
Schistosoma mansoni microtubule-associated protein tau 0.0576 0.2612 0.362
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0012 0.0017
Schistosoma mansoni smad1 5 8 and 0.0026 0.0088 0.0094
Onchocerca volvulus 0.0259 0.1158 0.1589
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0249 0.111 0.3325
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0558 0.2532 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Loa Loa (eye worm) RiNg Finger protein family member 0.0028 0.0097 0.0133
Toxoplasma gondii LsmAD domain-containing protein 0.0037 0.0137 0.0188
Trypanosoma cruzi WLM domain containing protein, putative 0.0558 0.2532 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0037 0.0139 0.7316
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0061 0.0545
Plasmodium vivax hypothetical protein, conserved 0.1569 0.718 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0137 0.0141
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0346 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0024 0.0033
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0061 0.0545
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.003 0.0103 0.0317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Schistosoma mansoni fusion 0.0558 0.2532 0.3508
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0088 0.0121
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0209 0.0289
Loa Loa (eye worm) hypothetical protein 0.0558 0.2532 0.3526
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0033
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0028 0.0097 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0139 0.0193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0116 0.0118
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0033
Brugia malayi Cell death protein 3 precursor 0.002 0.0058 0.0052
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0028 0.0097 0.0084
Echinococcus multilocularis Smad4 0.0026 0.0088 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0103 0.0144
Trypanosoma brucei predicted zinc finger protein 0.0028 0.0097 0.029
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0037 0.0139 0.7316
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0249 0.111 1
Brugia malayi hypothetical protein 0.0028 0.0097 0.0106
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0037 0.0139 0.0457
Echinococcus granulosus tumor protein p63 0.1772 0.811 1
Entamoeba histolytica hypothetical protein 0.0033 0.0116 0.5176
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0069 0.0096
Schistosoma mansoni hypothetical protein 0.002 0.0058 0.0052
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0037 0.0139 0.0457
Echinococcus granulosus ring finger protein 113a 0.0028 0.0097 0.0094
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Brugia malayi hypothetical protein 0.0028 0.0097 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.1569 0.718 1
Schistosoma mansoni zinc finger protein 0.0028 0.0097 0.0106
Trypanosoma brucei hypothetical protein, conserved 0.0558 0.2532 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0037 0.0139 0.0457
Brugia malayi MH1 domain containing protein 0.0026 0.0088 0.0094
Giardia lamblia GTOR 0.0037 0.0139 1
Brugia malayi hypothetical protein 0.0033 0.0116 0.0133
Leishmania major hypothetical protein, conserved 0.0558 0.2532 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Onchocerca volvulus 0.0558 0.2532 0.3508
Onchocerca volvulus 0.0028 0.0097 0.0106
Toxoplasma gondii CAAX metallo endopeptidase 0.0044 0.0167 0.0229
Brugia malayi RNA binding protein 0.0053 0.0209 0.0263
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0028 0.0097 0.0135
Echinococcus granulosus caspase 2 0.002 0.0058 0.0046
Schistosoma mansoni Replicative DNA helicase 0.0249 0.111 0.1522
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0037 0.0139 0.0457
Brugia malayi Zinc finger protein 183 homolog 0.0028 0.0097 0.0106
Loa Loa (eye worm) hypothetical protein 0.0558 0.2532 0.3526
Onchocerca volvulus 0.0028 0.0097 0.0106
Schistosoma mansoni Smad4 0.0026 0.0088 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0061 0.0545
Brugia malayi hypothetical protein 0.0028 0.0097 0.0106
Schistosoma mansoni peter pan-related 0.0028 0.0097 0.0106
Toxoplasma gondii target of rapamycin (TOR), putative 0.0028 0.0094 0.0128
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0028 0.0097 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0137 0.0141
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0021 0.0027
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Schistosoma mansoni hypothetical protein 0.0028 0.0097 0.0106
Brugia malayi Peptidase family M48 containing protein 0.0044 0.0167 0.0205
Leishmania major hypothetical protein, conserved 0.0558 0.2532 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0027
Schistosoma mansoni hypothetical protein 0.1569 0.718 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0103 0.0144
Leishmania major hypothetical protein 0.0028 0.0097 0.029
Onchocerca volvulus 0.0057 0.0227 0.0288
Echinococcus granulosus zinc finger protein Ran binding 0.0558 0.2532 0.3105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0061 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Plasmodium vivax DNA repair protein RAD5, putative 0.0028 0.0097 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0558 0.2532 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0139 0.0193
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0088 0.0121
Leishmania major hypothetical protein, conserved 0.0558 0.2532 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0261 0.1165 0.1621
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0037 0.0139 0.0165
Entamoeba histolytica SPRY domain protein 0.0028 0.0097 0.3401
Leishmania major hypothetical protein, conserved 0.0037 0.0137 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0004
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0013 0.0024 0.0004
Brugia malayi MH1 domain containing protein 0.0026 0.0088 0.0094
Loa Loa (eye worm) hypothetical protein 0.0558 0.2532 0.3526
Schistosoma mansoni smad 0.0026 0.0088 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0028 0.0097 0.0094
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trichomonas vaginalis ankyrin, putative 0.0028 0.0097 0.0135
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0028 0.0097 0.0135
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0028 0.0097 0.0094
Schistosoma mansoni smad1 5 8 and 0.0026 0.0088 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0037 0.0139 0.0146
Echinococcus granulosus apoptotic protease activating factor 1 0.002 0.0058 0.0046
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1569 0.718 0.885
Brugia malayi Neuralized family protein 0.0028 0.0097 0.0106
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0061 0.0545
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0059 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Plasmodium falciparum zinc finger protein, putative 0.0028 0.0097 0.0084
Schistosoma mansoni brg-1 associated factor 0.1569 0.718 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trypanosoma cruzi hypothetical protein 0.0028 0.0097 0.029
Leishmania major hypothetical protein, unknown function 0.0028 0.0097 0.029
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0028 0.0097 0.0084
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0061 0.0545
Loa Loa (eye worm) hypothetical protein 0.0061 0.0245 0.034
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0044 0.0167 0.0205
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0088 0.0083
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0028 0.0097 0.0094
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0061 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0024 0.0033
Echinococcus granulosus ring and YY1 binding protein 0.0558 0.2532 0.3105
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Treponema pallidum replicative DNA helicase (dnaB) 0.0249 0.111 1
Brugia malayi hypothetical protein 0.0028 0.0097 0.0106
Schistosoma mansoni cpg binding protein 0.002 0.0056 0.005
Onchocerca volvulus 0.0558 0.2532 0.3508
Toxoplasma gondii hypothetical protein 0.0028 0.0097 0.0131
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0249 0.111 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0131
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Echinococcus granulosus smad 0.0026 0.0088 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0131
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0068 0.0095
Toxoplasma gondii hypothetical protein 0.0028 0.0097 0.0131
Loa Loa (eye worm) twinkle helicase 0.0071 0.0293 0.0406
Loa Loa (eye worm) RNA binding protein 0.0053 0.0209 0.0289
Echinococcus granulosus microtubule associated protein 2 0.0576 0.2612 0.3204
Trypanosoma cruzi DNA repair protein, putative 0.0021 0.0065 0.0162
Brugia malayi hypothetical protein 0.0028 0.0097 0.0106
Loa Loa (eye worm) hypothetical protein 0.0061 0.0245 0.034
Trypanosoma cruzi hypothetical protein 0.0028 0.0097 0.029
Loa Loa (eye worm) hypothetical protein 0.0261 0.1165 0.1621
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Schistosoma mansoni cpg binding protein 0.002 0.0056 0.005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0017 0.0043 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0558 0.2532 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0037 0.0137 0.0452
Brugia malayi MH1 domain containing protein 0.0015 0.0033 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0013 0.0024 0.0005
Trypanosoma brucei target of rapamycin kinase 3, putative 0.003 0.0103 0.0317
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Mycobacterium leprae Conserved hypothetical protein 0.0734 0.334 1
Mycobacterium ulcerans recombinase A 0.0069 0.0286 0.2573
Onchocerca volvulus Protein neuralized homolog 0.0028 0.0097 0.0106
Schistosoma mansoni hypothetical protein 0.0558 0.2532 0.3508
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Schistosoma mansoni hypothetical protein 0.0263 0.1177 0.1616
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0346 0.0402
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0028 0.0097 0.0135
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0131
Leishmania major DNA repair protein-like protein 0.0028 0.0097 0.029
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0028 0.0097 0.0135
Entamoeba histolytica hypothetical protein 0.0028 0.0097 0.3401
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0079
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0028 0.0097 0.029
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0558 0.2532 1
Echinococcus granulosus tar DNA binding protein 0.0053 0.0209 0.0233
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0028 0.0097 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0061 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0059 0.0082
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0028 0.0097 0.0094
Schistosoma mansoni hypothetical protein 0.0028 0.0097 0.0106
Echinococcus multilocularis ring and YY1 binding protein 0.0558 0.2532 0.3105
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Entamoeba histolytica CAAX prenyl protease, putative 0.0044 0.0167 1
Schistosoma mansoni hypothetical protein 0.0083 0.0346 0.0454
Entamoeba histolytica hypothetical protein 0.0033 0.0116 0.5176
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Echinococcus multilocularis RING finger protein 185 0.0028 0.0097 0.0094
Echinococcus granulosus caax prenyl protease 1 0.0044 0.0167 0.0181
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Chlamydia trachomatis DNA topoisomerase I 0.1569 0.718 1
Echinococcus granulosus dnaJ subfamily B 0.0263 0.1177 0.143
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0013 0.0024 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0263 0.1177 0.143
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0028 0.0097 0.0094
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Schistosoma mansoni hypothetical protein 0.0017 0.0043 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0103 0.0144
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0018 0.0048 0.0094
Brugia malayi MH2 domain containing protein 0.0026 0.0088 0.0094
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0088 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0059 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0097 0.0106
Onchocerca volvulus Putative RING finger protein 207 0.0028 0.0097 0.0106
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0061 0.0056
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Chlamydia trachomatis replicative DNA helicase 0.0249 0.111 0.1503
Schistosoma mansoni hypothetical protein 0.1569 0.718 1
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0028 0.0097 0.0094
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.0051 0.007
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0558 0.2532 1
Schistosoma mansoni mind bomb 0.0028 0.0097 0.0106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0037 0.033
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0558 0.2532 0.3105
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0558 0.2532 0.3105
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Brugia malayi TAR-binding protein 0.0053 0.0209 0.0263
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0044 0.0167 0.0571
Trypanosoma brucei PAB1-binding protein , putative 0.0037 0.0137 0.0452
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0044 0.0167 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0097 0.029
Echinococcus multilocularis SWI:SNF matrix associated 0.1569 0.718 0.885
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0002
Loa Loa (eye worm) Smad1 0.0026 0.0088 0.0121
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0016 0.0038 0.0055
Echinococcus granulosus ring finger protein 170 0.0028 0.0097 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0078 0.0109
Trichomonas vaginalis ankyrin, putative 0.0028 0.0097 0.0135
Brugia malayi brahma associated protein 60 kDa 0.1569 0.718 1
Leishmania major hypothetical protein, conserved 0.0558 0.2532 1
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Echinococcus multilocularis caspase 2 0.002 0.0058 0.0046
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0558 0.2532 1
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0028 0.0097 0.029
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0558 0.2532 0.3105
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0558 0.2532 0.3525
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0037 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0028 0.0097 0.0131
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Loa Loa (eye worm) nuclear factor I 0.0015 0.0033 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0346 0.0402
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0558 0.2532 1
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0028 0.0097 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0061 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0097 0.029
Schistosoma mansoni RNA binding protein 0.0558 0.2532 0.3508
Brugia malayi hypothetical protein 0.0028 0.0097 0.0106
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0028 0.0097 0.0135
Plasmodium vivax ataxin-2 like protein, putative 0.0037 0.0137 0.0141
Brugia malayi RING zinc finger protein 0.0028 0.0097 0.0106
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0044 0.0167 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Schistosoma mansoni hypothetical protein 0.0178 0.0786 0.1069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0116 0.0118
Schistosoma mansoni peter pan-related 0.0028 0.0097 0.0106
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0028 0.0097 0.0135
Onchocerca volvulus 0.0028 0.0097 0.0106
Onchocerca volvulus 0.0061 0.0245 0.0314
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0037 0.0139 0.0457
Echinococcus multilocularis microtubule associated protein 2 0.0576 0.2612 0.3204
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0061 0.0061
Entamoeba histolytica zinc finger domain containing protein 0.0028 0.0097 0.3401
Echinococcus granulosus cpg binding protein 0.002 0.0056 0.0044
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0037 0.0139 0.0146
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0028 0.0097 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0088 0.0094
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0028 0.0097 0.0135
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1569 0.718 1
Chlamydia trachomatis SWIB complex protein 0.1569 0.718 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0024 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0037 0.0137 0.0452
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0097 0.029
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0017 0.0043 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0049
Echinococcus granulosus SWI:SNF matrix associated 0.1569 0.718 0.885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0131
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0037 0.0139 0.0457
Loa Loa (eye worm) hypothetical protein 0.0558 0.2532 0.3526
Echinococcus granulosus Zinc finger RanBP2 type 0.0558 0.2532 0.3105
Brugia malayi Zinc finger, C2H2 type family protein 0.0028 0.0097 0.0106
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0028 0.0097 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0116 0.0133
Entamoeba histolytica hypothetical protein 0.0033 0.0116 0.5176
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0059 0.0082
Brugia malayi Smad1 0.0026 0.0088 0.0094
Loa Loa (eye worm) peptidase family M48 containing protein 0.0044 0.0167 0.0231
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0044 0.0167 0.0571
Brugia malayi YY1-associated factor 2 0.0558 0.2532 0.3508
Trypanosoma cruzi DNA repair protein, putative 0.0021 0.0065 0.0162
Schistosoma mansoni hypothetical protein 0.0083 0.0346 0.0454
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0044 0.0167 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0209 0.0263
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0028 0.0097 0.0135
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1569 0.718 0.885
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0033
Toxoplasma gondii RING zinc finger protein 0.0028 0.0097 0.0131
Echinococcus multilocularis SWI:SNF matrix associated 0.1569 0.718 0.885
Plasmodium falciparum RING zinc finger protein, putative 0.0028 0.0097 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Loa Loa (eye worm) hypothetical protein 0.0083 0.0346 0.048
Entamoeba histolytica hypothetical protein 0.0033 0.0116 0.5176
Brugia malayi MH1 domain containing protein 0.0015 0.0033 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0346 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0103 0.0144
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.2003 0.9175 0.9175
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0346 0.0454
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0033 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0261 0.1165 0.1599
Loa Loa (eye worm) RING finger protein 20 0.0028 0.0097 0.0133
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0069 0.0286 0.2573
Echinococcus granulosus Smad4 0.0026 0.0088 0.0083
Chlamydia trachomatis recombinase RecA 0.0069 0.0286 0.0349
Toxoplasma gondii helicase, putative 0.0028 0.0097 0.0131
Brugia malayi Trypsin family protein 0.0061 0.0245 0.0314
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1569 0.718 1
Leishmania major hypothetical protein, conserved 0.0028 0.0097 0.029
Schistosoma mansoni hypothetical protein 0.0028 0.0097 0.0106
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1569 0.718 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Onchocerca volvulus 0.0558 0.2532 0.3508
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0558 0.2532 1
Leishmania major hypothetical protein, conserved 0.0558 0.2532 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0061 0.0146
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0061 0.0181
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0558 0.2532 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0033 0.0045
Schistosoma mansoni hypothetical protein 0.0083 0.0346 0.0454
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0049
Echinococcus granulosus cell growth regulator with ring finger domain 0.0028 0.0097 0.0094
Brugia malayi MH2 domain containing protein 0.0026 0.0088 0.0094
Onchocerca volvulus 0.0558 0.2532 0.3508
Echinococcus multilocularis tumor protein p63 0.1772 0.811 1
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0069 0.0286 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0069 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0028 0.0097 0.0131
Onchocerca volvulus 0.0028 0.0097 0.0106
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0028 0.0097 0.029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0139 0.0165
Brugia malayi brahma associated protein 60 kDa 0.1569 0.718 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0024 0.0033
Echinococcus multilocularis zinc finger protein Ran binding 0.0558 0.2532 0.3105
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0082
Schistosoma mansoni smad1 5 8 and 0.0026 0.0088 0.0094
Brugia malayi CXXC zinc finger family protein 0.0018 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0049
Echinococcus granulosus RING finger protein 185 0.0028 0.0097 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.0786 0.1069
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0028 0.0097 0.0131
Plasmodium vivax zinc finger protein, putative 0.0028 0.0097 0.0084
Trypanosoma cruzi WLM domain containing protein, putative 0.0558 0.2532 1
Schistosoma mansoni hypothetical protein 0.0083 0.0346 0.0454
Loa Loa (eye worm) hypothetical protein 0.0028 0.0097 0.0133
Toxoplasma gondii histone lysine methyltransferase SET1 0.0035 0.0127 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0097 0.0135
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0061 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0069 0.0096

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = -9 In vitro antihypertensive activity in renal hypertensive rat at 0.5 mg/kg after 7 hr of oral administration. ChEMBL. 7932534
Activity (functional) = -8 In vitro antihypertensive activity in renal hypertensive rat at 0.5 mg/kg after 5 hr of oral administration. ChEMBL. 7932534
Activity (functional) = -1 In vitro antihypertensive activity in renal hypertensive rat at 0.5 mg/kg after 24 hr of oral administration. ChEMBL. 7932534
Ki (binding) = -9.4 Tested for in vitro binding affinity against angiotensin II receptor of rat liver ChEMBL. 7932534
Log Ki (binding) = 9.4 Tested for in vitro binding affinity against angiotensin II receptor of rat liver ChEMBL. 7932534

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.