Detailed information for compound 1748449

Basic information

Technical information
  • TDR Targets ID: 1748449
  • Name: (1S)-1-[(2R)-6-fluorochroman-2-yl]-2-[[(2S)-2 -[(2R)-6-fluorochroman-2-yl]-2-hydroxyethyl]a mino]ethanol
  • MW: 405.435 | Formula: C22H25F2NO4
  • H donors: 3 H acceptors: 2 LogP: 3.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]([C@@H]1CCc2c(O1)ccc(c2)F)CNC[C@@H]([C@H]1CCc2c(O1)ccc(c2)F)O
  • InChi: 1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/m0/s1
  • InChiKey: KOHIRBRYDXPAMZ-YHDSQAASSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S)-1-[(2R)-6-fluorochroman-2-yl]-2-[[(2S)-2-[(2R)-6-fluorochroman-2-yl]-2-hydroxy-ethyl]amino]ethanol
  • (1S)-1-[(2R)-6-fluoro-2-chromanyl]-2-[[(2S)-2-[(2R)-6-fluoro-2-chromanyl]-2-hydroxyethyl]amino]ethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0122 0.0474 0.3021
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1038 0.1029
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0075 0.0431
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0063 0.0197 0.0703
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0198 0.0837 0.3133
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0232 0.0844
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0118 0.0402
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0075 0.0431
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0232 0.0844
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0145 0.0882
Plasmodium falciparum phosphoglycerate kinase 0.0196 0.0827 1
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0278 0.105
Trypanosoma brucei phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Mycobacterium ulcerans leucyl aminopeptidase 0.0122 0.0474 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.008 0.0174
Echinococcus granulosus phosphoglycerate kinase 1 0.0196 0.0827 0.0818
Entamoeba histolytica deoxycytidyl transferase, putative 0.0076 0.0258 0.0635
Mycobacterium ulcerans beta-lactamase 0.0036 0.0068 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0415 0.0415
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0076 0.0258 0.0248
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0232 0.1447
Echinococcus granulosus neuropeptide s receptor 0.0463 0.2089 0.2081
Entamoeba histolytica phosphoglycerate kinase, putative 0.0196 0.0827 0.2579
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0075 0.0431
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0012 0.0012
Echinococcus granulosus expressed protein 0.0039 0.008 0.007
Toxoplasma gondii leucyl aminopeptidase LAP 0.0122 0.0474 0.5681
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.0258 0.0258
Loa Loa (eye worm) glutaminase 0.058 0.2646 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0083 0.0291 0.0281
Schistosoma mansoni alpha-glucosidase 0.0143 0.0574 0.0574
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0012 0.0046
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0047 0.0134
Plasmodium falciparum M17 leucyl aminopeptidase 0.0122 0.0474 0.5681
Loa Loa (eye worm) hypothetical protein 0.0083 0.0291 0.1099
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0072 0.0062
Schistosoma mansoni hypothetical protein 0.0053 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0942
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0407 0.0398
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0194 0.0185
Trypanosoma brucei unspecified product 0.0052 0.0146 0.0889
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.1546 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0028 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0206 0.0206
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0116 0.0295
Schistosoma mansoni lamin 0.0056 0.0162 0.0162
Mycobacterium ulcerans DNA polymerase IV 0.0134 0.0533 0.1985
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0145 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Loa Loa (eye worm) doublecortin family protein 0.004 0.0086 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.013 0.0447
Trichomonas vaginalis chromobox protein, putative 0.008 0.0278 0.0841
Trypanosoma brucei unspecified product 0.0052 0.0146 0.0889
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0012 0.0012
Schistosoma mansoni polycystin 1-related 0.004 0.0086 0.0086
Mycobacterium ulcerans hypothetical protein 0.0036 0.0068 0.0223
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0012 0.0003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0076 0.0067
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0229 0.1197
Giardia lamblia Kinase, PLK 0.0109 0.0415 0.1358
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0127 0.0273
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0145 0.0135
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Leishmania major calcium channel protein, putative,ion transporter, putative 0.006 0.018 0.1108
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0129 0.0781
Onchocerca volvulus 0.004 0.0086 0.0094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0683 0.2582
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0097 0.0355 0.0346
Brugia malayi hypothetical protein 0.004 0.0086 0.028
Schistosoma mansoni intermediate filament proteins 0.0056 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0045 0.011 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0415 0.2642
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0028 0.0028
Schistosoma mansoni rotamase 0.0039 0.008 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0229 0.2688
Brugia malayi Pre-SET motif family protein 0.0454 0.2049 0.7732
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0086 0.0076
Loa Loa (eye worm) pre-B cell enhancing factor 0.0418 0.1877 0.7096
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0415 0.1538
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0415 0.2642
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0072 0.0147
Trypanosoma cruzi DNA polymerase eta, putative 0.0105 0.0397 0.2521
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0108 0.0407 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0155 0.0427
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0012 0.0003
Echinococcus multilocularis dna polymerase kappa 0.0134 0.0533 0.0524
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0116 0.0295
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Echinococcus multilocularis lamin 0.0056 0.0162 0.0152
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0083 0.0291 0.0281
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0324
Echinococcus granulosus lamin dm0 0.0056 0.0162 0.0152
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0206 0.2406
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0068 0.0382
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.001 0.001
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0145 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0324
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0072 0.0238 0.1492
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0407
Schistosoma mansoni DNA polymerase eta 0.0105 0.0397 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Onchocerca volvulus 0.0096 0.0352 0.1259
Schistosoma mansoni lamin 0.0056 0.0162 0.0162
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0258 0.0636
Schistosoma mansoni rab6-interacting 0.004 0.0086 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0118 0.0109
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0086 0.0938
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Trichomonas vaginalis rotamase, putative 0.0039 0.008 0.0174
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0148 0.0905
Trypanosoma brucei phosphoglycerate kinase 0.0196 0.0827 0.5318
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0118 0.0109
Loa Loa (eye worm) hypothetical protein 0.0214 0.0911 0.3443
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0418 0.1877 0.1877
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0071 0.0235 0.1471
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.0134 0.0533 0.3405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0678 0.4349
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.1546 1
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Echinococcus multilocularis GPCR, family 2 0.0049 0.0129 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0218 0.0209
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0218 0.0218
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.0217 0.0217
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0134
Schistosoma mansoni hypothetical protein 0.0195 0.0823 0.0823
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0076 0.0258 0.0258
Brugia malayi N-terminal motif family protein 0.0214 0.0911 0.3413
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0162 0.0567
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0072 0.0226
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0028 0.0028
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0683 0.2547
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0407 0.0398
Mycobacterium ulcerans lipase LipD 0.0036 0.0068 0.0223
Mycobacterium ulcerans ion transport protein 0.0093 0.0336 0.1241
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.008 0.0301
Schistosoma mansoni hypothetical protein 0.0049 0.013 0.013
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0127 0.0332
Schistosoma mansoni hypothetical protein 0.0106 0.0398 0.0398
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0407 0.0398
Schistosoma mansoni kinase 0.0056 0.0162 0.0162
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Onchocerca volvulus 0.0049 0.013 0.0287
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0038 0.0077 0.0834
Onchocerca volvulus 0.0036 0.0068 0.0015
Loa Loa (eye worm) glutaminase 2 0.058 0.2646 1
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0106 0.0097
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0047 0.0038
Schistosoma mansoni voltage-gated cation channel 0.0108 0.0407 0.0407
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Brugia malayi chromobox protein homolog 3 0.0045 0.0111 0.0374
Loa Loa (eye worm) hypothetical protein 0.0196 0.0827 0.3124
Echinococcus granulosus leucine aminopeptidase protein 0.0122 0.0474 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0258 0.1617
Echinococcus multilocularis muscleblind protein 0.0172 0.0713 0.0704
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0078 0.0265 0.0265
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0258 0.0932
Echinococcus granulosus intermediate filament protein 0.0056 0.0162 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0284 0.1788
Brugia malayi Doublecortin family protein 0.004 0.0086 0.028
Loa Loa (eye worm) hypothetical protein 0.0106 0.0398 0.1504
Schistosoma mansoni glutaminase 0.058 0.2646 0.2646
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0072 0.0271
Brugia malayi MAP kinase sur-1 0.0052 0.0145 0.0503
Loa Loa (eye worm) calcium channel 0.0108 0.0407 0.154
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0068 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.018 0.1111
Echinococcus granulosus dna polymerase eta 0.0105 0.0397 0.0388
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0229 0.1429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.063 0.2345
Mycobacterium ulcerans hypothetical protein 0.0183 0.0766 0.287
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0055 0.0157 0.0592
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.032 0.1412 0.5322
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0232 0.0222
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.008 0.0256
Echinococcus multilocularis leucine aminopeptidase protein 0.0122 0.0474 0.0465
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.0217 0.0217
Leishmania major hypothetical protein, conserved 0.0036 0.0068 0.0382
Brugia malayi Heterochromatin protein 1 0.008 0.0278 0.1008
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0415 0.1531
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0238 0.1025 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0028 0.0028 0.0019
Echinococcus multilocularis dna polymerase eta 0.0105 0.0397 0.0388
Mycobacterium ulcerans DNA polymerase IV 0.0134 0.0533 0.1985
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0118 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0076
Brugia malayi polk-prov protein 0.0082 0.0284 0.1032
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.063 0.238
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0258 0.0249
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0122 0.0474 0.3021
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0258 0.1411
Leishmania major DNA polymerase kappa, putative 0.009 0.0326 0.206
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0068 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0134
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.0464 0.2961
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0086 0.0076
Onchocerca volvulus 0.0056 0.0162 0.0426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0196 0.0827 1
Schistosoma mansoni lipoxygenase 0.0166 0.0686 0.0686
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0326 0.206
Schistosoma mansoni survival motor neuron protein 0.0049 0.013 0.013
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0072 0.0765
Schistosoma mansoni alpha glucosidase 0.0037 0.0072 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0111 0.0278
Brugia malayi intermediate filament protein 0.0056 0.0162 0.0567
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0072 0.0062
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0028 0.0028 0.0019
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Schistosoma mansoni hypothetical protein 0.004 0.0086 0.0086
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Loa Loa (eye worm) hypothetical protein 0.0172 0.0713 0.2695
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0111 0.0278
Echinococcus granulosus sodium channel protein 0.006 0.018 0.017
Trichomonas vaginalis chromobox protein, putative 0.008 0.0278 0.0841
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0145 0.0882
Plasmodium vivax SET domain protein, putative 0.0065 0.0206 0.2406
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0078 0.0268 0.0268
Brugia malayi jmjC domain containing protein 0.007 0.0228 0.0819
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.1546 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0238 0.1025 0.1017
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0232 0.0232
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0196 0.0827 1
Echinococcus granulosus Solute carrier family 22 5 0.125 0.5818 0.5814
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0326 0.1918
Brugia malayi Pre-B cell enhancing factor precursor 0.0418 0.1877 0.7082
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0228 0.0862
Loa Loa (eye worm) hypothetical protein 0.0198 0.0837 0.3165
Brugia malayi Phosphoglycerate kinase 0.0196 0.0827 0.3093
Loa Loa (eye worm) hypothetical protein 0.0105 0.0397 0.15
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0145 0.0882
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0678 0.4349
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0122 0.0474 0.5681
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0063 0.0197 0.0188
Toxoplasma gondii ABC1 family protein 0.0036 0.0068 0.0719
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0047 0.0038
Schistosoma mansoni rab6-interacting 0.004 0.0086 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0068 0.0212
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0009 0.0009
Plasmodium vivax phosphoglycerate kinase, putative 0.0196 0.0827 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0415 0.0406
Mycobacterium ulcerans phosphoglycerate kinase 0.0196 0.0827 0.31
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Trypanosoma brucei DNA polymerase eta, putative 0.0105 0.0397 0.2521
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0326 0.206
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0106 0.0097
Brugia malayi Muscleblind-like protein 0.0172 0.0713 0.2661
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0028 0.0028 0.0019
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.0659
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0162 0.0611
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0145 0.0882
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0655 0.2999 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0407 0.154
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0229 0.0229
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0028 0.0028 0.0019
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0454 0.2049 0.7743
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0214 0.0911 0.371
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0086 0.0076
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0012 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.0056 0.0162 0.0611
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Echinococcus multilocularis sodium channel protein 0.0097 0.0355 0.0346
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0122 0.0474 0.3017
Brugia malayi Bromodomain containing protein 0.0079 0.0271 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0756 0.245
Onchocerca volvulus 0.004 0.0086 0.0094
Trypanosoma brucei glucosidase, putative 0.0037 0.0072 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0129 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0291 0.0291
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0291 0.0291
Onchocerca volvulus 0.0036 0.0068 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.2089 0.2081
Echinococcus multilocularis phosphoglycerate kinase 1 0.0196 0.0827 0.0818
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0229 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0068 0.0223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0118 0.0109
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0039 0.0101
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0415 0.157
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0145 0.0135
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0068 0.0223
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0196 0.0827 0.5643
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0129 0.012
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0218 0.0209
Mycobacterium ulcerans glutaminase 0.058 0.2646 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0141 0.0564 0.2094
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0228 0.0228
Leishmania major phosphoglycerate kinase B, cytosolic 0.0196 0.0827 0.5318
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0075 0.0431
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.2089 0.2081
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.0407 0.0398
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Loa Loa (eye worm) hypothetical protein 0.0053 0.0148 0.056
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0194 0.0185
Brugia malayi hypothetical protein 0.004 0.0086 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0048 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0655 0.2999 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0068
Echinococcus multilocularis expressed protein 0.0039 0.008 0.007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0852 0.3933 0.3927
Echinococcus multilocularis chromobox protein 1 0.008 0.0278 0.0269
Onchocerca volvulus 0.0036 0.0068 0.0015
Echinococcus granulosus RUN 0.004 0.0086 0.0076
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.0418 0.1877 0.187
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0086 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Echinococcus multilocularis lamin dm0 0.0056 0.0162 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0196 0.0827 0.2688
Schistosoma mansoni loxhd1 0.004 0.0086 0.0086
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0012 0.0046
Brugia malayi Cyclic-nucleotide gated cation channel 0.0028 0.0028 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0076 0.0067
Chlamydia trachomatis phosphoglycerate kinase 0.0196 0.0827 1
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0122 0.0474 0.3017
Schistosoma mansoni phosphoglycerate kinase 0.0196 0.0827 0.0827
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0244
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0189 0.0716
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0415 0.1174
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0226
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0047 0.0038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0111 0.0418
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0145 0.0882
Brugia malayi Bromodomain containing protein 0.004 0.0088 0.0288
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.3124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0118 0.0109
Loa Loa (eye worm) voltage-dependent calcium channel 0.0034 0.006 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Trypanosoma brucei phosphoglycerate kinase 0.0072 0.0238 0.1492
Giardia lamblia Fructose-bisphosphate aldolase 0.0655 0.2999 1
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0086 0.0938
Leishmania major phosphoglycerate kinase C, glycosomal 0.0196 0.0827 0.5318
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0028 0.0106
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0047 0.0047
Treponema pallidum fructose-bisphosphate aldolase 0.0655 0.2999 1
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0122 0.0474 0.3021
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0382
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0407 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0415 0.2642
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0025 0.0015
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0108 0.0407 0.1501
Onchocerca volvulus 0.0078 0.0268 0.0893
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0078 0.0265 0.0265
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0195 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.0134 0.0533 0.3405
Echinococcus granulosus dna polymerase kappa 0.0134 0.0533 0.0524
Onchocerca volvulus 0.0056 0.0162 0.0426
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0028 0.0106
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Loa Loa (eye worm) hypothetical protein 0.0155 0.063 0.238
Giardia lamblia Phosphoglycerate kinase 0.0196 0.0827 0.2734
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0108 0.0407 0.0398
Treponema pallidum phosphoglycerate kinase 0.0196 0.0827 0.2056
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0145 0.0547
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0232 0.1218
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0053 0.0148 0.1702
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Trichomonas vaginalis set domain proteins, putative 0.0517 0.2346 0.7801
Echinococcus granulosus geminin 0.0195 0.0823 0.0814
Brugia malayi Pre-SET motif family protein 0.0065 0.0206 0.0736
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0196 0.0827 0.5318
Echinococcus granulosus lamin 0.0056 0.0162 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Leishmania major DNA polymerase eta, putative 0.0105 0.0397 0.2521
Trichomonas vaginalis DNA polymerase eta, putative 0.0134 0.0533 0.1698
Loa Loa (eye worm) hypothetical protein 0.0241 0.1038 0.3922
Schistosoma mansoni hypothetical protein 0.0195 0.0823 0.0823
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0108 0.0407 0.0407
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0086 0.0076
Echinococcus multilocularis geminin 0.0195 0.0823 0.0814
Trypanosoma brucei unspecified product 0.012 0.0464 0.2961
Schistosoma mansoni bromodomain containing protein 0.0066 0.0212 0.0212
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0134 0.0533 0.1698
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0075 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.0766 0.5192
Brugia malayi glutaminase DH11.1 0.058 0.2646 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.0713 0.2695
Trypanosoma brucei phosphoglycerate kinase 0.0196 0.0827 0.5318
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0108 0.0407 0.0398
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0229 0.022
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0407 0.0398
Loa Loa (eye worm) beta-lactamase 0.0036 0.0068 0.0257
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.0796
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0218 0.0209
Loa Loa (eye worm) hypothetical protein 0.0082 0.0284 0.1073
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.032 0.1412 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0129 0.0444
Loa Loa (eye worm) voltage-gated potassium channel 0.0123 0.0482 0.1822
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.1546 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.063 0.2345
Echinococcus multilocularis musashi 0.0056 0.0162 0.0152
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0258 0.0258
Trypanosoma brucei polo-like protein kinase 0.0109 0.0415 0.2642
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0072 0.0407
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0145 0.0135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0179
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0108 0.0407 0.0398
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0141 0.0564 0.0555
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.032 0.1412 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0196 0.0827 0.5643
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0415 0.0406
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0206 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0284 0.1788
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0076 0.0258 0.0974
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0196 0.0827 0.2688
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0075 0.081
Schistosoma mansoni chromobox protein 0.008 0.0278 0.0278
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0258 0.0249
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0232 0.0833
Brugia malayi ImpB/MucB/SamB family protein 0.0105 0.0397 0.146
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0212
Echinococcus granulosus chromobox protein 1 0.008 0.0278 0.0269
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Brugia malayi Phosphoglycerate kinase 0.0072 0.0238 0.0859
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0063 0.0197 0.0745
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.2089 0.2081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0068 0.0059
Echinococcus multilocularis microtubule associated protein 2 0.2133 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0111 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0398 0.1465
Schistosoma mansoni phosphoglycerate kinase 0.0196 0.0827 0.0827
Brugia malayi beta-lactamase 0.0036 0.0068 0.0212
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0145 0.0135
Schistosoma mansoni lipoxygenase 0.0238 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0094
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0258 0.0933
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0229 0.0229
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0141 0.0564 0.0555
Onchocerca volvulus 0.0517 0.2346 1
Trichomonas vaginalis esterase, putative 0.0036 0.0068 0.0134
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0078 0.0265 0.1462
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0122 0.0474 0.3021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0129 0.0488
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0063 0.0197 0.0188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus multilocularis muscleblind protein 1 0.0172 0.0713 0.0704
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0141 0.0564 0.0564
Echinococcus granulosus muscleblind protein 0.0172 0.0713 0.0704
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0012 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1038 0.1029
Toxoplasma gondii hypothetical protein 0.0056 0.0163 0.1886
Echinococcus multilocularis RUN 0.004 0.0086 0.0076
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.0418 0.1877 0.187
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0068 0.0719
Schistosoma mansoni chromobox protein 0.008 0.0278 0.0278
Echinococcus granulosus GPCR family 2 0.0049 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0488
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0127 0.0332
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0196 0.0827 1
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0047 0.0047
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0106
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0039 0.0147
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0076
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.006 0.005
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0228 0.0228
Echinococcus granulosus chromobox protein 1 0.008 0.0278 0.0269
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0048 0.0068
Giardia lamblia DINP protein human, muc B family 0.009 0.0326 0.1059
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0129 0.012
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0129 0.0444
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0071 0.0235 0.1471
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0228 0.0219
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0155 0.0427
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0145 0.0882
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0212
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Trichomonas vaginalis glutaminase, putative 0.058 0.2646 0.8811
Schistosoma mansoni alpha-glucosidase 0.0143 0.0574 0.0574
Brugia malayi hypothetical protein 0.0241 0.1038 0.3894
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0076 0.0258 0.0248
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.006 0.062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Trichomonas vaginalis rotamase, putative 0.0038 0.0075 0.016
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0678 0.4349
Brugia malayi PHD-finger family protein 0.0026 0.0021 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0145 0.0882
Leishmania major DNA polymerase eta, putative 0.0053 0.0148 0.0905
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0162 0.0611
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0232 0.0222
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0258 0.0974
Schistosoma mansoni microtubule-associated protein tau 0.2133 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.0987 0.6839
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0145 0.1658
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0086 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0196 0.0827 0.5318
Loa Loa (eye worm) hypothetical protein 0.0043 0.01 0.0378
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0078 0.0265 0.1462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus multilocularis chromobox protein 1 0.008 0.0278 0.0269
Trypanosoma brucei protein kinase, putative 0.0052 0.0145 0.0882
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0407 0.0398
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0047 0.0038
Brugia malayi jmjC domain containing protein 0.0068 0.0218 0.0783
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0334

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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