Detailed information for compound 1750618

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.45 | Formula: C16H22N6OS
  • H donors: 1 H acceptors: 2 LogP: 1.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCNc1nc2cc(sc2c(=O)n1C)c1cnn(c1)C)C
  • InChi: 1S/C16H22N6OS/c1-20(2)7-5-6-17-16-19-12-8-13(11-9-18-21(3)10-11)24-14(12)15(23)22(16)4/h8-10H,5-7H2,1-4H3,(H,17,19)
  • InChiKey: WNZXWGLHKRXALK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1601 0.3866
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0335 0.0775
Onchocerca volvulus Troponin I homolog 0.012 0.1811 0.1863
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0018 0.0022
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.6528 1
Onchocerca volvulus 0.017 0.2595 0.2935
Schistosoma mansoni tsg101-related 0.0065 0.0946 0.1735
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.1089 0.2003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0775 0.0998
Brugia malayi hypothetical protein 0.0078 0.1152 0.1484
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0828 0.1979
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1601 0.3866
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1089 0.6769
Echinococcus granulosus importin subunit beta 1 0.0032 0.0431 0.0512
Brugia malayi MH1 domain containing protein 0.0009 0.0065 0.0083
Brugia malayi Importin beta-1 subunit 0.0032 0.0431 0.0555
Entamoeba histolytica hypothetical protein 0.0026 0.0335 0.0513
Schistosoma mansoni ferritin 0.001 0.0071 0.01
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.1089 0.1325
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.032 0.0565
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.1089 0.1403
Echinococcus granulosus neuropeptide s receptor 0.052 0.8103 1
Schistosoma mansoni importin beta-1 0.0032 0.0431 0.0773
Brugia malayi hypothetical protein 0.017 0.2595 0.3344
Schistosoma mansoni zinc finger protein 0.0017 0.0192 0.0326
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.1601 0.2062
Leishmania major hypothetical protein, conserved 0.0017 0.0192 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0127 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0127 0.0267
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0149 0.2265 0.2484
Schistosoma mansoni hypothetical protein 0.012 0.1811 0.3351
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0201 0.0226
Brugia malayi MH2 domain containing protein 0.0009 0.0065 0.0083
Schistosoma mansoni hypothetical protein 0.0023 0.0286 0.0502
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0828 0.1979
Echinococcus multilocularis smad 0.0009 0.0065 0.0059
Echinococcus multilocularis snurportin 1 0.0346 0.5368 0.6617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0201 0.0226
Echinococcus granulosus troponin i 0.012 0.1811 0.2218
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0071 0.1042 0.0811
Onchocerca volvulus 0.0266 0.4112 0.5012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0978 0.1187
Schistosoma mansoni lozenge 0.0062 0.0904 0.1657
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.1601 0.1958
Brugia malayi Troponin I 0.012 0.1811 0.2333
Schistosoma mansoni hypothetical protein 0.004 0.0558 0.1009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0201 0.05
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.1601 0.1958
Schistosoma mansoni apoferritin-2 0.001 0.0071 0.01
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0765 0.0924
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0031 0.0086
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0882 0.1069
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0828 0.512
Brugia malayi Troponin T 0.0071 0.1042 0.1342
Brugia malayi hypothetical protein 0.004 0.0558 0.0718
Brugia malayi Pre-SET motif family protein 0.0034 0.0449 0.0578
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.1601 0.2062
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.064 1 1
Schistosoma mansoni troponin I 0.012 0.1811 0.3351
Echinococcus granulosus expressed protein 0.001 0.0071 0.0066
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0201 0.0342
Schistosoma mansoni hypothetical protein 0.0017 0.0192 0.0326
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.1601 1
Schistosoma mansoni ferritin 0.001 0.0071 0.01
Echinococcus multilocularis zinc finger protein 0.0022 0.0268 0.0309
Schistosoma mansoni hypothetical protein 0.0346 0.5368 1
Leishmania major hypothetical protein, conserved 0.0025 0.0315 0.1876
Brugia malayi Bromodomain containing protein 0.0043 0.0599 0.0771
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0053 0.0758 0.1161
Schistosoma mansoni ferritin light chain 0.001 0.0071 0.01
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0018 0.0027
Onchocerca volvulus 0.0498 0.7758 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.1089 0.1325
Echinococcus granulosus zinc finger protein 0.0022 0.0268 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0757 0.1805
Echinococcus multilocularis kelch ECH associated protein 1 0.0106 0.1592 0.1947
Loa Loa (eye worm) hypothetical protein 0.0078 0.1152 0.1484
Schistosoma mansoni hypothetical protein 0.0326 0.5052 0.941
Brugia malayi hypothetical protein 0.0498 0.7758 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1089 0.6529
Loa Loa (eye worm) hypothetical protein 0.0046 0.0642 0.0827
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.1089 0.1668
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0449 0.5326
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0828 0.1002
Schistosoma mansoni troponin t invertebrate 0.0149 0.2265 0.4201
Brugia malayi hypothetical protein 0.0071 0.1042 0.1342
Trichomonas vaginalis set domain proteins, putative 0.0266 0.4112 1
Brugia malayi kap beta 3 protein 0.0006 0.0018 0.0022
Entamoeba histolytica hypothetical protein 0.004 0.0558 0.0854
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0071 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.2034 0.262
Schistosoma mansoni ferritin 0.001 0.0071 0.01
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0223 0.0384
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0431 0.2613
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0557 0.0667
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0882 0.1616
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0558 0.1009
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0223 0.0384
Loa Loa (eye worm) hypothetical protein 0.0043 0.06 0.0773
Loa Loa (eye worm) runx1 0.0062 0.0904 0.1165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0676 0.087
Schistosoma mansoni hypothetical protein 0.0018 0.02 0.0341
Schistosoma mansoni survival motor neuron protein 0.0054 0.0775 0.1415
Plasmodium falciparum importin beta, putative 0.0032 0.0431 1
Entamoeba histolytica hypothetical protein 0.004 0.0558 0.0854
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0201 0.05
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0751 0.0907
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1601 0.3866
Echinococcus granulosus survival motor neuron protein 1 0.0266 0.4105 0.5055
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0765 0.1397
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0065 0.0083
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.1089 0.1403
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0431 0.2613
Schistosoma mansoni hypothetical protein 0.0018 0.02 0.0341
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0201 0.0258
Trypanosoma brucei polo-like protein kinase 0.0107 0.1601 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0201 0.0258
Giardia lamblia Kinase, PLK 0.0107 0.1601 0.1355
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0828 0.1979
Brugia malayi MH2 domain containing protein 0.0134 0.2034 0.262
Brugia malayi Troponin T 0.0071 0.1042 0.1342
Entamoeba histolytica hypothetical protein 0.0013 0.0127 0.0195
Trichomonas vaginalis hypothetical protein 0.0038 0.052 0.1228
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0065 0.0089
Loa Loa (eye worm) hypothetical protein 0.0038 0.0524 0.0675
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0201 0.2258
Trypanosoma cruzi ISWI complex protein 0.0017 0.0192 0.044
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0335 0.1411
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0828 0.4758
Echinococcus multilocularis Smad4 0.0009 0.0065 0.0059
Schistosoma mansoni hypothetical protein 0.0191 0.2919 0.5424
Echinococcus granulosus ferritin 0.001 0.0071 0.0066
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0828 0.4758
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0201 0.0226
Brugia malayi Latrophilin receptor protein 2 0.0018 0.02 0.0257
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0078 0.1152 0.1402
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0335 0.0775
Loa Loa (eye worm) hypothetical protein 0.012 0.1811 0.2333
Loa Loa (eye worm) hypothetical protein 0.0498 0.7758 1
Brugia malayi PHD-finger family protein 0.0028 0.0362 0.0466
Loa Loa (eye worm) hypothetical protein 0.012 0.1811 0.2333
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0828 0.1002
Entamoeba histolytica hypothetical protein 0.004 0.0558 0.0854
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0558 0.0668
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0882 0.1136
Echinococcus granulosus kelch ECH associated protein 1 like 0.0106 0.1592 0.1947
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.064 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0335 0.0775
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0765 0.0432
Echinococcus multilocularis troponin i 0.012 0.1811 0.2218
Schistosoma mansoni smad1 5 8 and 0.0009 0.0065 0.0089
Plasmodium vivax SET domain protein, putative 0.0034 0.0449 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0201 0.0226
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0286 0.0368
Brugia malayi MAP kinase sur-1 0.0058 0.0828 0.1067
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0803 0.1034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.02 0.0226
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0828 0.1067
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0201 0.1156
Brugia malayi Pre-SET motif family protein 0.0234 0.3604 0.4644
Loa Loa (eye worm) troponin 0.0071 0.1042 0.1342
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.02 0.0226
Entamoeba histolytica hypothetical protein 0.0013 0.0127 0.0195
Schistosoma mansoni tsg101-related 0.0065 0.0946 0.1735
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1089 0.6529
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1601 0.3866
Entamoeba histolytica hypothetical protein 0.0119 0.1801 0.2759
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0803 0.1034
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0065 0.0059
Schistosoma mansoni tsg101-related 0.0053 0.0758 0.1384
Echinococcus granulosus geminin 0.0191 0.2919 0.3589
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0757 0.1805
Loa Loa (eye worm) hypothetical protein 0.0053 0.0751 0.0967
Schistosoma mansoni ferritin light chain 0.001 0.0071 0.01
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0765 0.0924
Onchocerca volvulus 0.0054 0.0775 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0828 0.1515
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.1089 0.6769
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0449 0.0534
Echinococcus granulosus Smad4 0.0009 0.0065 0.0059
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0597 0.0717
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0882 0.1069
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0201 0.4425
Echinococcus multilocularis GPCR, family 2 0.0018 0.02 0.0226
Echinococcus multilocularis neuropeptide receptor A26 0.052 0.8103 1
Echinococcus granulosus kelch ECH associated protein 1 like 0.0106 0.1592 0.1947
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0524 0.0675
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0765 0.0924
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0765 0.0924
Schistosoma mansoni zinc finger protein 0.0022 0.0268 0.0467
Echinococcus multilocularis geminin 0.0191 0.2919 0.3589
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.5368 0.6918
Schistosoma mansoni smad 0.0009 0.0065 0.0089
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0828 1
Schistosoma mansoni hypothetical protein 0.0018 0.02 0.0341
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0431 0.5104
Trichomonas vaginalis ferritin, putative 0.001 0.0071 0.0131
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0234 0.03
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0223 0.0254
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0557 0.0667
Echinococcus multilocularis ferritin 0.001 0.0071 0.0066
Schistosoma mansoni hypothetical protein 0.0054 0.0775 0.1415
Entamoeba histolytica hypothetical protein 0.004 0.0558 0.0854
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0751 0.1371
Echinococcus multilocularis kelch ECH associated protein 1 0.0106 0.1592 0.1947
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.02 0.0257
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0558 0.0668
Schistosoma mansoni kinase 0.0054 0.0779 0.1423
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0449 0.0807
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0201 0.2258
Schistosoma mansoni hypothetical protein 0.0018 0.02 0.0341
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0071 0.1042 0.1342
Schistosoma mansoni Smad4 0.0009 0.0065 0.0089
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0828 0.512
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0201 0.1156
Echinococcus multilocularis Protein lozenge 0.0062 0.0904 0.1097
Schistosoma mansoni smad1 5 8 and 0.0009 0.0065 0.0089
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0882 0.1069
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.032 0.0374
Schistosoma mansoni smad1 5 8 and 0.0009 0.0065 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.1601 0.2959
Schistosoma mansoni bromodomain containing protein 0.0071 0.1041 0.1912
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0149 0.2265 0.278
Loa Loa (eye worm) hypothetical protein 0.0266 0.4105 0.5291
Trypanosoma brucei protein kinase, putative 0.0058 0.0828 0.512
Echinococcus multilocularis Kelch repeat type 1 0.0106 0.1597 0.1953
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0201 0.424
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0828 0.1002
Giardia lamblia DNA repair protein RAD52 0.042 0.6528 1
Echinococcus granulosus oncosphere protein Tso22e 0.0149 0.2265 0.278
Schistosoma mansoni troponin I 0.012 0.1811 0.3351
Trypanosoma brucei ISWI complex protein 0.0017 0.0192 0.11
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.1601 0.1575
Echinococcus granulosus kelch ECH associated protein 1 0.0106 0.1592 0.1947
Schistosoma mansoni troponin I 0.012 0.1811 0.3351
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0065 0.0083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.02 0.0226
Brugia malayi MH2 domain containing protein 0.0009 0.0065 0.0083
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0882 0.1069
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0751 0.0907
Loa Loa (eye worm) hypothetical protein 0.0054 0.0765 0.0985
Loa Loa (eye worm) hypothetical protein 0.008 0.1173 0.151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.02 0.0226
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0223 0.0254
Schistosoma mansoni apoferritin-2 0.001 0.0071 0.01
Schistosoma mansoni ferritin 0.001 0.0071 0.01
Brugia malayi RNA, U transporter 1 0.0092 0.1372 0.1768
Brugia malayi Troponin family protein 0.012 0.1811 0.2333
Brugia malayi MH1 domain containing protein 0.0009 0.0065 0.0083
Brugia malayi Bromodomain containing protein 0.0084 0.1248 0.1608
Loa Loa (eye worm) Smad1 0.0009 0.0065 0.0083
Schistosoma mansoni hypothetical protein 0.0038 0.0524 0.0947
Loa Loa (eye worm) MBCTL1 0.0061 0.0882 0.1136
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.1801 0.2759
Schistosoma mansoni troponin I 0.012 0.1811 0.3351
Brugia malayi mbt repeat family protein 0.0054 0.0765 0.0985
Echinococcus granulosus GPCR family 2 0.0018 0.02 0.0226
Schistosoma mansoni hypothetical protein 0.0191 0.2919 0.5424
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0828 0.4758
Loa Loa (eye worm) troponin I 0.012 0.1811 0.2333
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.02 0.0257
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0065 0.0059
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0765 0.1397
Plasmodium vivax importin-beta 2, putative 0.0032 0.0431 0.9583
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0078 0.1152 0.1402
Loa Loa (eye worm) hypothetical protein 0.0056 0.0803 0.1034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0803 0.1034
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0201 0.0226
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0025 0.0315 0.1274
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0201 0.1156
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.1601 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0449 0.0807
Leishmania major importin beta-1 subunit, putative 0.0026 0.0335 0.2004
Onchocerca volvulus 0.0054 0.0765 0.0432
Echinococcus granulosus snurportin 1 0.0346 0.5368 0.6617
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0201 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0431 0.0555
Schistosoma mansoni hypothetical protein 0.0106 0.1597 0.2952
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0828 0.1002
Brugia malayi mbt repeat family protein 0.0054 0.0765 0.0985
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.1601 0.2452
Entamoeba histolytica hypothetical protein 0.0013 0.0127 0.0195
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.3247 0.3994
Echinococcus multilocularis expressed protein 0.001 0.0071 0.0066
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.3247 0.3994
Trypanosoma cruzi ISWI complex protein 0.0017 0.0192 0.044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0201 0.0226
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.1601 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.3604 0.4644
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0828 0.512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0751 0.1371
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.043 0.051
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0431 0.0512
Brugia malayi Troponin T 0.0071 0.1042 0.1342
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0978 0.1187
Echinococcus multilocularis survival motor neuron protein 1 0.0266 0.4105 0.5055
Entamoeba histolytica hypothetical protein 0.0013 0.0127 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1601 0.3866
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0071 0.5
Brugia malayi hypothetical protein 0.0266 0.4105 0.5291
Loa Loa (eye worm) troponin T 0.0071 0.1042 0.1342
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1601 0.3866
Loa Loa (eye worm) hypothetical protein 0.0018 0.02 0.0257
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0065 0.0059
Brugia malayi Smad1 0.0009 0.0065 0.0083
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.2034 0.262
Echinococcus granulosus smad 0.0009 0.0065 0.0059
Brugia malayi isocitrate dehydrogenase 0.0018 0.0201 0.0258
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0597 0.0717
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0765 0.1397
Echinococcus multilocularis neuropeptide s receptor 0.052 0.8103 1
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0025 0.0315 0.1876
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0065 0.0059
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.032 0.0374
Echinococcus granulosus neuropeptide receptor A26 0.052 0.8103 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0828 0.4758
Loa Loa (eye worm) hypothetical protein 0.0498 0.7758 1
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0828 0.1979
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0127 0.0691
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0765 0.0985
Loa Loa (eye worm) hypothetical protein 0.0061 0.0882 0.1136
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1601 0.3866
Loa Loa (eye worm) hypothetical protein 0.017 0.2595 0.3344

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 10.19 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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