Detailed information for compound 175411

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.468 | Formula: C22H27N3O3
  • H donors: 3 H acceptors: 3 LogP: 2.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN[C@H](C(=O)N1Cc2ccccc2CC1C(=O)N)Cc1c(C)cc(cc1C)O
  • InChi: 1S/C22H27N3O3/c1-13-8-17(26)9-14(2)18(13)11-19(24-3)22(28)25-12-16-7-5-4-6-15(16)10-20(25)21(23)27/h4-9,19-20,24,26H,10-12H2,1-3H3,(H2,23,27)/t19-,20?/m0/s1
  • InChiKey: OPHUJOIWOCVSQQ-XJDOXCRVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Cavia porcellus Mu opioid receptor Starlite/ChEMBL References
Mus musculus opioid receptor, delta 1 Starlite/ChEMBL References
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Mu opioid receptor   98 aa 85 aa 24.7 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Mu opioid receptor   98 aa 92 aa 32.6 %
Echinococcus multilocularis tachykinin peptides receptor 99D Mu opioid receptor   98 aa 93 aa 25.8 %
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Schistosoma japonicum Neuropeptide Y receptor type 2, putative Mu opioid receptor   98 aa 79 aa 31.6 %
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor Mu opioid receptor   98 aa 80 aa 37.5 %
Onchocerca volvulus Mu opioid receptor   98 aa 79 aa 21.5 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Mu opioid receptor   98 aa 79 aa 36.7 %
Onchocerca volvulus Mu opioid receptor   98 aa 100 aa 25.0 %
Echinococcus multilocularis biogenic amine (5HT) receptor Mu opioid receptor   98 aa 96 aa 30.2 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Mu opioid receptor   98 aa 97 aa 36.1 %
Echinococcus granulosus biogenic amine 5HT receptor Mu opioid receptor   98 aa 97 aa 35.1 %
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Mu opioid receptor   98 aa 97 aa 37.1 %
Schistosoma mansoni biogenic amine (dopamine) receptor Mu opioid receptor   98 aa 97 aa 35.1 %
Schistosoma mansoni biogenic amine receptor Mu opioid receptor   98 aa 97 aa 38.1 %
Schistosoma japonicum Neuropeptide Y receptor, putative Mu opioid receptor   98 aa 100 aa 29.0 %
Schistosoma mansoni biogenic amine (dopamine) receptor Mu opioid receptor   98 aa 88 aa 39.8 %
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a Mu opioid receptor   98 aa 96 aa 29.2 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 92 aa 31.5 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Echinococcus granulosus neuropeptide receptor Mu opioid receptor   98 aa 88 aa 22.7 %
Schistosoma japonicum Muscarinic acetylcholine receptor M1, putative Mu opioid receptor   98 aa 95 aa 30.5 %
Echinococcus granulosus biogenic amine 5HT receptor Mu opioid receptor   98 aa 96 aa 30.2 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Onchocerca volvulus Mu opioid receptor   98 aa 96 aa 28.1 %
Schistosoma mansoni hypothetical protein Mu opioid receptor   98 aa 100 aa 23.0 %
Echinococcus multilocularis neuropeptide FF receptor 2 Mu opioid receptor   98 aa 84 aa 31.0 %
Onchocerca volvulus Phospholipase d-related homolog Mu opioid receptor   98 aa 82 aa 25.6 %
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Mu opioid receptor   98 aa 79 aa 34.2 %
Schistosoma mansoni neuropeptide receptor Mu opioid receptor   98 aa 93 aa 24.7 %
Schistosoma japonicum Octopamine receptor, putative Mu opioid receptor   98 aa 98 aa 37.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Mu opioid receptor   98 aa 97 aa 36.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a Mu opioid receptor   98 aa 96 aa 29.2 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Schistosoma mansoni biogenic amine (5HT) receptor Mu opioid receptor   98 aa 97 aa 34.0 %
Onchocerca volvulus Mu opioid receptor   98 aa 80 aa 35.0 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 98 aa 31.6 %
Schistosoma japonicum ko:K04282 thyrotropin-releasing hormone receptor, putative Mu opioid receptor   98 aa 100 aa 28.0 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Echinococcus multilocularis g protein coupled receptor Mu opioid receptor   98 aa 81 aa 24.7 %
Echinococcus granulosus g protein coupled receptor Mu opioid receptor   98 aa 92 aa 26.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Schistosoma mansoni neuropeptide receptor Mu opioid receptor   98 aa 81 aa 34.6 %
Echinococcus granulosus neuropeptide Y receptor Mu opioid receptor   98 aa 95 aa 32.6 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Mu opioid receptor   98 aa 89 aa 38.2 %
Echinococcus multilocularis serotonin receptor Mu opioid receptor   98 aa 97 aa 35.1 %
Echinococcus multilocularis neuropeptide Y receptor Mu opioid receptor   98 aa 95 aa 32.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Mu opioid receptor   98 aa 80 aa 31.2 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Mu opioid receptor   98 aa 98 aa 34.7 %
Schistosoma japonicum Probable G-protein coupled receptor No9, putative Mu opioid receptor   98 aa 95 aa 28.4 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Mu opioid receptor   98 aa 93 aa 33.3 %
Onchocerca volvulus Mu opioid receptor   98 aa 81 aa 33.3 %
Onchocerca volvulus Mu opioid receptor   98 aa 96 aa 24.0 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Onchocerca volvulus Mu opioid receptor   98 aa 81 aa 25.9 %
Echinococcus granulosus neuropeptide FF receptor 2 Mu opioid receptor   98 aa 84 aa 31.0 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 79 aa 29.1 %
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Echinococcus granulosus alpha 1A adrenergic receptor Mu opioid receptor   98 aa 92 aa 21.7 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Schistosoma mansoni growth hormone secretagogue receptor Mu opioid receptor   98 aa 93 aa 24.7 %
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor Mu opioid receptor   98 aa 100 aa 29.0 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 81 aa 35.8 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Mu opioid receptor   98 aa 89 aa 40.4 %
Onchocerca volvulus Mu opioid receptor   98 aa 80 aa 22.5 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Mu opioid receptor   98 aa 96 aa 31.2 %
Brugia malayi Melatonin receptor type 1A Mu opioid receptor   98 aa 80 aa 22.5 %
Onchocerca volvulus Mu opioid receptor   98 aa 101 aa 20.8 %
Schistosoma japonicum Octopamine receptor, putative Mu opioid receptor   98 aa 88 aa 37.5 %
Onchocerca volvulus Mu opioid receptor   98 aa 79 aa 31.6 %
Echinococcus multilocularis g protein coupled receptor Mu opioid receptor   98 aa 92 aa 26.1 %
Schistosoma japonicum FMRFamide receptor, putative Mu opioid receptor   98 aa 109 aa 28.4 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Schistosoma mansoni rhodopsin-like orphan GPCR Mu opioid receptor   98 aa 85 aa 25.9 %
Onchocerca volvulus Mu opioid receptor   98 aa 87 aa 32.2 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 93 aa 30.1 %
Schistosoma mansoni thyrotropin-releasing hormone receptor Mu opioid receptor   98 aa 100 aa 27.0 %
Schistosoma mansoni biogenic amine receptor Mu opioid receptor   98 aa 98 aa 35.7 %
Echinococcus granulosus tachykinin peptides receptor 99D Mu opioid receptor   98 aa 93 aa 25.8 %
Onchocerca volvulus Mu opioid receptor   98 aa 93 aa 36.6 %
Schistosoma mansoni biogenic amine receptor Mu opioid receptor   98 aa 91 aa 38.5 %
Loa Loa (eye worm) melatonin receptor type 1A Mu opioid receptor   98 aa 80 aa 22.5 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Mu opioid receptor   98 aa 93 aa 25.8 %
Schistosoma mansoni opsin-like receptor Mu opioid receptor   98 aa 80 aa 25.0 %
Echinococcus multilocularis rhodopsin orphan GPCR Mu opioid receptor   98 aa 80 aa 23.8 %
Echinococcus granulosus g protein coupled receptor Mu opioid receptor   98 aa 81 aa 24.7 %
Schistosoma mansoni adenoreceptor Mu opioid receptor   98 aa 88 aa 38.6 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Schistosoma japonicum Neuropeptide Y receptor, putative Mu opioid receptor   98 aa 88 aa 23.9 %
Loa Loa (eye worm) TYRA-2 protein Mu opioid receptor   98 aa 87 aa 31.0 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma mansoni neuropeptide receptor Mu opioid receptor   98 aa 95 aa 32.6 %
Brugia malayi G protein-coupled receptor Mu opioid receptor   98 aa 90 aa 31.1 %
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor Mu opioid receptor   98 aa 100 aa 29.0 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 92 aa 23.9 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Mu opioid receptor   98 aa 96 aa 32.3 %
Schistosoma mansoni amine GPCR Mu opioid receptor   98 aa 86 aa 32.6 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 96 aa 31.2 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Mu opioid receptor   98 aa 80 aa 28.8 %
Onchocerca volvulus Mu opioid receptor   98 aa 79 aa 27.8 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Mu opioid receptor   98 aa 85 aa 32.9 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   98 aa 85 aa 32.9 %
Loa Loa (eye worm) hypothetical protein Mu opioid receptor   98 aa 85 aa 37.6 %
Schistosoma mansoni histamine-responsive GPCR (AAF21638) Mu opioid receptor   98 aa 99 aa 36.4 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Mu opioid receptor   98 aa 90 aa 28.9 %
Echinococcus multilocularis neuropeptide receptor Mu opioid receptor   98 aa 88 aa 22.7 %
Onchocerca volvulus Mu opioid receptor   98 aa 86 aa 33.7 %
Brugia malayi larval opioid receptor Mu opioid receptor   98 aa 100 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0517 0.3178 0.0585
Mycobacterium ulcerans thioesterase 0.0461 0.2666 0.443
Onchocerca volvulus 0.0963 0.7265 0.9327
Toxoplasma gondii type I fatty acid synthase, putative 0.0588 0.3826 1
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0487 0.2904 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0553 0.3511 0.581
Loa Loa (eye worm) hypothetical protein 0.0487 0.2904 0.3446
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0224 0.0491 0.0817
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0174 0.0034 0.0056
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0553 0.3511 0.5834
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0827 0.6018 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0445 0.252 0.4188
Mycobacterium ulcerans fatty acid synthase Fas 0.0174 0.0034 0.0056
Schistosoma mansoni hypothetical protein 0.0487 0.2904 0.5
Loa Loa (eye worm) fatty acid synthase 0.0546 0.3443 0.4318
Mycobacterium ulcerans Type I modular polyketide synthase 0.0553 0.3511 0.5834
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1261 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0366 0.1794 0.2981
Brugia malayi AMP-binding enzyme family protein 0.0517 0.3178 0.3948
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0588 0.3826 0.6337
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0397 0.2083 0.3461
Mycobacterium ulcerans thioesterase TesA 0.0461 0.2666 0.443
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0487 0.2904 0.3607
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0517 0.3178 0.3889
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1049 0.805 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0359 0.173 0.2574
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0588 0.3826 0.6357
Toxoplasma gondii type I fatty acid synthase, putative 0.0394 0.205 0.3708
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0445 0.252 0.4155
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0452 0.2587 0.4299
Mycobacterium leprae Polyketide synthase Pks13 0.0827 0.6018 1
Mycobacterium ulcerans polyketide synthase Pks9 0.0366 0.1794 0.2981
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0553 0.3511 0.5834
Mycobacterium ulcerans Type I modular polyketide synthase 0.0553 0.3511 0.5834
Mycobacterium leprae Probable polyketide synthase Pks1 0.0588 0.3826 0.6337
Mycobacterium ulcerans Type I modular polyketide synthase 0.0553 0.3511 0.5834
Mycobacterium ulcerans polyketide synthase Pks13 0.0827 0.6018 1
Mycobacterium ulcerans polyketide synthase 0.0553 0.3511 0.5834
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0588 0.3826 0.6357
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0536 0.3356 0.5576
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0461 0.2666 0.4398
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0588 0.3826 0.6337
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.019 0.0184 0.0306
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0315 0.1323 0.2199
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0445 0.252 0.4188
Mycobacterium tuberculosis Probable thioesterase TesA 0.0461 0.2666 0.443
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0553 0.3511 0.4361
Mycobacterium ulcerans polyketide synthase 0.0588 0.3826 0.6357
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0536 0.3356 0.5576
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0487 0.2904 0.3607
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0588 0.3826 0.6357
Loa Loa (eye worm) hypothetical protein 0.0929 0.6958 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0517 0.3178 0.528
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0553 0.3511 0.5834
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0553 0.3511 0.581
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0366 0.1794 0.2941
Loa Loa (eye worm) hypothetical protein 0.031 0.1282 0.0823
Loa Loa (eye worm) hypothetical protein 0.0487 0.2904 0.3446
Onchocerca volvulus Fatty acid synthase homolog 0.0997 0.758 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0827 0.6018 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0487 0.2904 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0553 0.3511 0.5834
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0588 0.3826 0.6357
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0588 0.3826 0.6357

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibitory activity against Opioid receptor mu 1 in an invitro guinea pig ileum assay ChEMBL. 9301674
IC50 (binding) > 10 uM Inhibitory activity against Opioid receptor mu 1 in an invitro guinea pig ileum assay ChEMBL. 9301674
Kd (functional) = 1 Antagonist activity against Opioid receptor mu 1 iin a guinea pig ileum assay ChEMBL. 9301674
Kd (functional) = 8.6 Antagonist activity against Opioid receptor delta 1 in mouse vas deferens assay ChEMBL. 9301674
Ki (binding) = 0.383 nM Binding affinity for Opioid receptor delta 1 by displacement of [3H]- DPDPE ChEMBL. 9301674
Ki (binding) = 0.383 nM Binding affinity for Opioid receptor delta 1 by displacement of [3H]- DPDPE ChEMBL. 9301674
Ki (binding) = 954.9 nM Binding affinity for Opioid receptor mu 1 by displacement of [3H]- DAGO ChEMBL. 9301674
Ki (binding) = 954.9 nM Binding affinity for Opioid receptor mu 1 by displacement of [3H]- DAGO ChEMBL. 9301674
pA2 (functional) = -1 Antagonist activity against Opioid receptor mu 1 iin a guinea pig ileum assay ChEMBL. 9301674
pA2 (functional) = 8.6 Antagonist activity against Opioid receptor delta 1 in mouse vas deferens assay ChEMBL. 9301674
Ratio (functional) > 4550 GPI/MVD ratio is based on Ke (antilog of pA2 value of antagonsitic activity of compound for delta opioid receptor) and IC50 values ChEMBL. 9301674
Ratio (binding) = 2493 Ratio of the affinity for delta and mu opioid receptors (Ki mu/Ki delta) shows delta opioid receptor selectivity ChEMBL. 9301674
Ratio (functional) > 4550 GPI/MVD ratio is based on Ke (antilog of pA2 value of antagonsitic activity of compound for delta opioid receptor) and IC50 values ChEMBL. 9301674

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.