TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.356 | Formula: C13H16N4O3S
H donors: 3 H acceptors: 2 LogP: 0.69 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)NC(=O)Nc1scc(n1)CN)OC
InChi: 1S/C13H16N4O3S/c1-19-9-3-4-11(20-2)10(5-9)16-12(18)17-13-15-8(6-14)7-21-13/h3-5,7H,6,14H2,1-2H3,(H2,15,16,17,18)
InChiKey: VXLJNRPFJWIPIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Smad4	0.0018	0.0032	0.0053
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog	0.0101	0.0637	0.0528
Loa Loa (eye worm)	hypothetical protein	0.054	0.3843	0.3843
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0101	0.0637	0.1171
Trypanosoma brucei	GPI ethanolamine phosphate transferase 3, putative	0.0101	0.0637	0.2319
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Schistosoma mansoni	cellular tumor antigen P53	0.011	0.0707	0.0698
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0118	0.0761	0.1401
Onchocerca volvulus		0.0641	0.4579	0.4517
Onchocerca volvulus		0.0118	0.0761	0.0654
Brugia malayi	beta-lactamase	0.0118	0.0761	0.0747
Schistosoma mansoni	smad	0.0018	0.0032	0.0022
Leishmania major	hypothetical protein, conserved	0.0027	0.01	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0761	0.0761
Brugia malayi	MH2 domain containing protein	0.0018	0.0032	0.0017
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.0032	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0175	0.0175
Onchocerca volvulus	GPI ethanolamine phosphate transferase 1 homolog	0.0101	0.0637	0.0528
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0074	0.0064
Plasmodium vivax	hypothetical protein, conserved	0.0118	0.0761	1
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0761	0.0761
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0171	0.0156
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0074	0.013
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.01	0.0334
Echinococcus multilocularis	smad	0.0018	0.0032	0.0053
Brugia malayi	hypothetical protein	0.0018	0.003	0.0014
Schistosoma mansoni	zinc finger protein	0.0021	0.0053	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0637	0.0637
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0101	0.0637	0.0627
Echinococcus multilocularis	cpg binding protein	0.0033	0.0142	0.0255
Loa Loa (eye worm)	type I phosphodiesterase/nucleotide pyrophosphatase	0.0101	0.0637	0.0637
Brugia malayi	Bromodomain containing protein	0.0075	0.0449	0.0435
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Schistosoma mansoni	hypothetical protein	0.042	0.2965	0.2958
Loa Loa (eye worm)	hypothetical protein	0.004	0.0192	0.0192
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0101	0.0637	0.1171
Schistosoma mansoni	hypothetical protein	0.0101	0.0637	0.0627
Schistosoma mansoni	cpg binding protein	0.0033	0.0142	0.0132
Brugia malayi	Bromodomain containing protein	0.0037	0.0175	0.016
Echinococcus granulosus	lamin dm0	0.0029	0.0114	0.0204
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Brugia malayi	beta-lactamase family protein	0.0118	0.0761	0.0747
Loa Loa (eye worm)	MH2 domain-containing protein	0.0264	0.1832	0.1832
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0026	0.004
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0118	0.0761	0.0751
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0118	0.0761	0.0761
Echinococcus multilocularis	Alkaline phosphatase, core domain	0.0101	0.0637	0.1171
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.01	0.0334
Plasmodium falciparum	GPI ethanolamine phosphate transferase 3, putative	0.0101	0.0637	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0641	0.4579	0.4574
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0026	0.004
Schistosoma mansoni	hypothetical protein	0.002	0.0048	0.0038
Loa Loa (eye worm)	hypothetical protein	0.011	0.0707	0.0707
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0385	0.2711	1
Echinococcus multilocularis	musashi	0.0029	0.0114	0.0204
Echinococcus granulosus	microtubule associated protein 2	0.0748	0.5362	0.9914
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0032	0.0022
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0101	0.0637	0.1171
Brugia malayi	Smad1	0.0018	0.0032	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0637	0.0637
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0027	0.0027
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Schistosoma mansoni	hypothetical protein	0.0017	0.0026	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0171	0.0171
Schistosoma mansoni	endonuclease related	0.0385	0.2711	0.2704
Brugia malayi	PHD-finger family protein	0.0026	0.0091	0.0076
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0637	0.0637
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0295	0.0281
Echinococcus granulosus	GPCR family 2	0.0017	0.0026	0.004
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0028	0.0044
Brugia malayi	beta-lactamase family protein	0.0118	0.0761	0.0747
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0158	0.0285
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.054	0.3843	0.7104
Brugia malayi	MH1 domain containing protein	0.0018	0.0032	0.0017
Brugia malayi	endonuclease G, mitochondrial precursor	0.0385	0.2711	0.27
Echinococcus granulosus	smad	0.0018	0.0032	0.0053
Brugia malayi	MH2 domain containing protein	0.0264	0.1832	0.182
Mycobacterium ulcerans	hypothetical protein	0.0118	0.0761	1
Leishmania major	endonuclease G, putative	0.0385	0.2711	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0032	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.0118	0.0761	0.2779
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0295	0.0281
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0158	0.0285
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0118	0.0761	1
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0114	0.0104
Onchocerca volvulus		0.0118	0.0761	0.0654
Schistosoma mansoni	hypothetical protein	0.0101	0.0637	0.0627
Trypanosoma cruzi	hypothetical protein, conserved	0.0118	0.0761	0.2779
Echinococcus multilocularis	dnaJ subfamily B	0.042	0.2965	0.5478
Schistosoma mansoni	lamin	0.0029	0.0114	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0027	0.01	0.01
Schistosoma mansoni	hypothetical protein	0.0101	0.0637	0.0627
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0325	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0761	0.0761
Echinococcus multilocularis	zinc finger protein	0.0021	0.0053	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0295	0.0295
Entamoeba histolytica	phosphatidylinositol-glycan biosynthesis class O protein, putative	0.0101	0.0637	0.5
Mycobacterium leprae	Probable lipase LipE	0.0118	0.0761	1
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0023	0.0035
Loa Loa (eye worm)	transcription factor SMAD2	0.0264	0.1832	0.1832
Schistosoma mansoni	hypothetical protein	0.0037	0.0171	0.0161
Trypanosoma brucei	hypothetical protein, conserved	0.0118	0.0761	0.2779
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0116	0.0101
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.034	0.0622
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Trypanosoma brucei	endonuclease G, putative	0.0385	0.2711	1
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog	0.0101	0.0637	0.0528
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0641	0.4579	0.4574
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.0032	0.0053
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0114	0.0114
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 3	0.0101	0.0637	0.1171
Loa Loa (eye worm)	Smad1	0.0018	0.0032	0.0032
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0116	0.0116
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0101	0.0637	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0004	0.0004
Trichomonas vaginalis	esterase, putative	0.0118	0.0761	0.5
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0026	0.004
Mycobacterium leprae	conserved hypothetical protein	0.0118	0.0761	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0026	0.004
Schistosoma mansoni	hypothetical protein	0.0101	0.0637	0.0627
Schistosoma mansoni	hypothetical protein	0.0017	0.0026	0.0015
Echinococcus granulosus	Smad4	0.0018	0.0032	0.0053
Leishmania major	ethanolamine phosphotransferase, putative	0.0101	0.0637	0.2319
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0637	0.0637
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.054	0.3843	0.7104
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0026	0.0011
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0026	0.0011
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 1	0.0101	0.0637	0.1171
Mycobacterium ulcerans	beta-lactamase	0.0118	0.0761	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.01	0.0334
Onchocerca volvulus	GPI ethanolamine phosphate transferase 2 homolog	0.0101	0.0637	0.0528
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0385	0.2711	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.0032	0.0053
Echinococcus granulosus	zinc finger protein	0.0021	0.0053	0.0091
Toxoplasma gondii	ABC1 family protein	0.0118	0.0761	0.253
Onchocerca volvulus	GPI ethanolamine phosphate transferase 3 homolog	0.0101	0.0637	0.0528
Trichomonas vaginalis	D-aminoacylase, putative	0.0118	0.0761	0.5
Schistosoma mansoni	hypothetical protein	0.0017	0.0026	0.0015
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Schistosoma mansoni	cpg binding protein	0.0033	0.0142	0.0132
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0023	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0029	0.011	0.011
Trypanosoma cruzi	endonuclease G, putative	0.0385	0.2711	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0118	0.0761	0.5
Trypanosoma cruzi	endonuclease G, putative	0.0385	0.2711	1
Loa Loa (eye worm)	hypothetical protein	0.0641	0.4579	0.4579
Schistosoma mansoni	hypothetical protein	0.1383	1	1
Echinococcus multilocularis	lamin dm0	0.0029	0.0114	0.0204
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0118	0.0761	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0218	0.0218
Echinococcus granulosus	Endonuclease G	0.0385	0.2711	0.5009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0028	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0641	0.4579	0.4579
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0641	0.4579	0.4571
Loa Loa (eye worm)	beta-lactamase	0.0118	0.0761	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0026	0.0026
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0385	0.2711	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0752	0.5395	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0015	0.0015
Brugia malayi	AEL166Cp	0.0101	0.0637	0.0622
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0357	0.0347
Brugia malayi	hypothetical protein	0.0027	0.01	0.0085
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0295	0.0295
Schistosoma mansoni	cpg binding protein	0.0029	0.0116	0.0106
Trichomonas vaginalis	D-aminoacylase, putative	0.0118	0.0761	0.5
Brugia malayi	hypothetical protein	0.0101	0.0637	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0761	0.0761
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0032	0.0022
Trichomonas vaginalis	penicillin-binding protein, putative	0.0118	0.0761	0.5
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0761	0.0761
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0032	0.0022
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0641	0.4579	0.4574
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0114	0.0114
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0028	0.0044
Echinococcus multilocularis	Endonuclease G	0.0385	0.2711	0.5009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0028	0.0017
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.0032	0.0053
Brugia malayi	MH1 domain containing protein	0.0018	0.0032	0.0017
Onchocerca volvulus		0.011	0.0707	0.06
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0032	0.0032
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0023	0.0013
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0074	0.013
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0026	0.004
Brugia malayi	hypothetical protein	0.0101	0.0637	0.0622
Entamoeba histolytica	phosphatidylinositol-glycan biosynthesis class O protein, putative	0.0101	0.0637	0.5
Brugia malayi	intermediate filament protein	0.0029	0.0114	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0641	0.4579	0.4579
Schistosoma mansoni	lamin	0.0029	0.0114	0.0104
Leishmania major	hypothetical protein, conserved	0.0118	0.0761	0.2779
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0406	0.0406
Trypanosoma brucei	endonuclease G, putative	0.0385	0.2711	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0118	0.0761	0.0747
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0023	0.0035
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.0032	0.0053
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.034	0.0622
Onchocerca volvulus		0.0641	0.4579	0.4517
Echinococcus granulosus	lamin	0.0029	0.0114	0.0204
Mycobacterium ulcerans	esterase/lipase LipP	0.0118	0.0761	1
Echinococcus granulosus	dnaJ subfamily B	0.042	0.2965	0.5478
Trypanosoma brucei	endonuclease G, putative	0.0385	0.2711	1
Echinococcus multilocularis	tumor protein p63	0.0754	0.5409	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0118	0.0761	0.1401
Echinococcus multilocularis	transferase	0.0101	0.0637	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0028	0.0028
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0048	0.0048
Onchocerca volvulus		0.0118	0.0761	0.0654
Echinococcus multilocularis	ectonucleotide	0.054	0.3843	0.7104
Echinococcus multilocularis	lamin	0.0029	0.0114	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0761	0.0761
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0114	0.0099
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0385	0.2711	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0641	0.4579	0.4574
Echinococcus granulosus	ectonucleotide	0.054	0.3843	0.7104
Mycobacterium ulcerans	lipase LipD	0.0118	0.0761	1
Onchocerca volvulus		0.1383	1	1
Echinococcus granulosus	intermediate filament protein	0.0029	0.0114	0.0204
Trichomonas vaginalis	D-aminoacylase, putative	0.0118	0.0761	0.5
Echinococcus granulosus	tumor protein p63	0.0754	0.5409	1
Brugia malayi	MH2 domain containing protein	0.0018	0.0032	0.0017
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.1383	1	1
Schistosoma mansoni	microtubule-associated protein tau	0.0748	0.5362	0.5358
Giardia lamblia	Phosphatidylinositol-glycan biosynthesis, class O protein	0.0101	0.0637	0.5
Echinococcus granulosus	cpg binding protein	0.0033	0.0142	0.0255
Schistosoma mansoni	Smad4	0.0018	0.0032	0.0022
Echinococcus granulosus	transferase	0.0101	0.0637	0.1171
Echinococcus multilocularis	microtubule associated protein 2	0.0748	0.5362	0.9914
Echinococcus granulosus	gpi ethanolamine phosphate transferase 3	0.0101	0.0637	0.1171
Schistosoma mansoni	bromodomain containing protein	0.0064	0.0366	0.0356
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0641	0.4579	0.8465
Onchocerca volvulus		0.0029	0.0116	0.0002
Schistosoma mansoni	hypothetical protein	0.0017	0.0026	0.0015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2354806

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1755096