Detailed information for compound 1777834

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.383 | Formula: C17H22N4O
  • H donors: 2 H acceptors: 3 LogP: 2.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@H](c1nc2c(n1C1CCCCC1)c1cc[nH]c1nc2)O
  • InChi: 1S/C17H22N4O/c1-2-14(22)17-20-13-10-19-16-12(8-9-18-16)15(13)21(17)11-6-4-3-5-7-11/h8-11,14,22H,2-7H2,1H3,(H,18,19)/t14-/m1/s1
  • InChiKey: HHCLTHAKVRSHMV-CQSZACIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Janus kinase 1 Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0139 0.0324 0.0454
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0197 0.0521 0.2089
Brugia malayi serine/threonine-protein kinase 6 0.0561 0.1754 0.2479
Echinococcus granulosus tyrosine kinase 0.0093 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0243
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0692 0.2198 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0108 0.0218 0.0309
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0242 0.0966
Echinococcus multilocularis peroxidasin 0.0047 0.0011 0.0015
Giardia lamblia Histone deacetylase 0.0221 0.0602 0.2639
Entamoeba histolytica protein kinase domain containing protein 0.0197 0.0521 0.2361
Brugia malayi hypothetical protein 0.0074 0.0102 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.001 0.0009
Echinococcus multilocularis protein KINase family member (kin 25) 0.0105 0.0207 0.0293
Echinococcus granulosus tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Brugia malayi histone deacetylase 1 (HD1) 0.0221 0.0602 0.0848
Entamoeba histolytica casein kinase 1, putative 0.006 0.0054 0.0235
Onchocerca volvulus 0.0286 0.0821 0.2714
Loa Loa (eye worm) SRC-1 0.0108 0.0218 0.0305
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0083 0.0131 0.0182
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0148 0.0355 0.0498
Echinococcus granulosus cyclin dependent kinase 19 0.0151 0.0363 0.0514
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.0242 0.0339
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.006 0.0054 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0194 0.027
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0053 0.0031 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0213 0.0297
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.005 0.0021 0.003
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0047 0.001 0.0014
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0101 0.0194 0.077
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0021 0.0026
Echinococcus granulosus hemicentin 1 0.0047 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0078 0.0116 0.016
Entamoeba histolytica protein kinase, putative 0.0561 0.1754 0.7975
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0104 0.0148
Giardia lamblia Aurora kinase 0.0561 0.1754 0.795
Echinococcus granulosus cyclin dependent kinase 9 0.0067 0.0078 0.011
Brugia malayi p70 ribosomal S6 kinase beta 0.0047 0.001 0.0009
Echinococcus granulosus tyrosine protein kinase HCK 0.0071 0.0092 0.013
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.0242 0.0339
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Entamoeba histolytica PH domain containing protein kinase, putative 0.0104 0.0205 0.0925
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Brugia malayi Serine/threonine-protein kinase SULU 0.0208 0.0556 0.0783
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0239 0.108
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0197 0.0521 0.2089
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.006 0.0053 0.0229
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0775 0.2481 1
Schistosoma mansoni tyrosine kinase 0.0446 0.1364 0.1927
Brugia malayi hypothetical protein 0.0208 0.0556 0.0783
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0099 0.0187 0.026
Echinococcus multilocularis roundabout 2 0.0146 0.0345 0.0489
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0243
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0692 0.2198 0.8858
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.008 0.0121 0.0167
Echinococcus granulosus Protein kinase C brain isozyme 0.0062 0.006 0.0085
Brugia malayi Immunoglobulin I-set domain containing protein 0.0099 0.0187 0.026
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Echinococcus multilocularis tyrosine protein kinase otk 0.0047 0.0009 0.0013
Echinococcus multilocularis 0.0647 0.2048 0.2899
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0105 0.0207 0.0289
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Giardia lamblia Kinase, CMGC GSK 0.0116 0.0246 0.0998
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Loa Loa (eye worm) gastrulation defective protein 1 0.0128 0.0286 0.0401
Echinococcus multilocularis casein kinase I alpha 0.006 0.0054 0.0076
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Brugia malayi cyclin-dependent kinase 7 homolog 0.0106 0.021 0.0293
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0104 0.0148
Echinococcus multilocularis mitogen activated protein kinase 11 0.0775 0.2481 0.3512
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0093 0.0166 0.0236
Echinococcus multilocularis 0.0692 0.2198 0.3111
Schistosoma mansoni hypothetical protein 0.0074 0.0102 0.014
Toxoplasma gondii aurora kinase 0.0561 0.1754 0.7974
Schistosoma mansoni serine/threonine kinase 0.006 0.0056 0.0075
Brugia malayi Protein kinase domain containing protein 0.0197 0.0521 0.0733
Brugia malayi probable protein kinase 0.0156 0.0379 0.0532
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0187 0.0485 0.0686
Brugia malayi protein kinase C II. 0.0062 0.006 0.0081
Trypanosoma cruzi aurora B kinase, putative 0.0561 0.1754 0.7064
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0062 0.006 0.0081
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.006 0.0053 0.0229
Plasmodium vivax histone deacetylase 2, putative 0.0171 0.043 0.1847
Mycobacterium ulcerans hypothetical protein 0.0548 0.1712 0.0916
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0246 0.1106
Echinococcus multilocularis histone deacetylase 7 0.0171 0.043 0.0609
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0561 0.1754 0.7975
Schistosoma mansoni protein kinase 0.0082 0.0128 0.0176
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0141 0.0329 0.1314
Trypanosoma brucei rac serine-threonine kinase, putative 0.005 0.0021 0.0072
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0314 0.0916 0.1293
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0108 0.0218 0.0309
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0246 0.1106
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0459 0.0645
Trypanosoma brucei cdc2-related kinase 1 0.0107 0.0213 0.0847
Brugia malayi Protein kinase domain containing protein 0.0141 0.0329 0.0461
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0208 0.0556 0.0787
Loa Loa (eye worm) AGC/PKN protein kinase 0.0047 0.001 0.0009
Schistosoma mansoni tyrosine kinase 0.081 0.2599 0.3675
Brugia malayi SH2 domain containing protein 0.0064 0.0069 0.0093
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0095 0.0175 0.0243
Plasmodium falciparum histone deacetylase 2 0.0171 0.043 0.1945
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0312 0.0437
Loa Loa (eye worm) hypothetical protein 0.0082 0.013 0.018
Loa Loa (eye worm) hypothetical protein 0.0105 0.0207 0.0288
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0045 0.0003 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0213 0.0957
Plasmodium falciparum protein kinase 5 0.0107 0.0213 0.0957
Mycobacterium ulcerans hypothetical protein 0.0548 0.1712 0.0916
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0179 0.0459 0.0649
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0083 0.0131 0.0182
Trypanosoma brucei histone deacetylase 2 0.0088 0.0151 0.0596
Giardia lamblia Kinase, NEK 0.0124 0.0271 0.1112
Echinococcus granulosus aurora kinase A 0.0561 0.1754 0.2482
Echinococcus multilocularis aurora kinase A 0.0561 0.1754 0.2482
Brugia malayi serine/threonine protein kinase 6 0.0561 0.1754 0.2479
Echinococcus multilocularis raf serine:threonine protein kinase 0.0057 0.0045 0.0064
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.006 0.0053 0.0229
Trypanosoma brucei protein kinase, putative 0.0065 0.0072 0.0278
Schistosoma mansoni histone deacetylase hda2 0.0088 0.0151 0.0209
Echinococcus granulosus TGF-beta receptor type-1 0.0093 0.0166 0.0236
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0221 0.0602 0.2727
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.006 0.0053 0.0076
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.0329 0.1483
Echinococcus granulosus tyrosine protein kinase shark 0.0064 0.0069 0.0097
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0187 0.0485 0.0686
Loa Loa (eye worm) IKK protein kinase 0.0928 0.2999 0.4242
Loa Loa (eye worm) hypothetical protein 0.006 0.0053 0.0071
Echinococcus granulosus activated cdc42 kinase 1 0.0205 0.0546 0.0772
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0108 0.0218 0.0309
Echinococcus granulosus histone deacetylase 6 0.0171 0.043 0.0609
Echinococcus granulosus tyrosine protein kinase otk 0.0047 0.0009 0.0013
Trypanosoma cruzi histone deacetylase, putative 0.0088 0.0151 0.0596
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 0.3108
Echinococcus multilocularis hemicentin 1 0.0047 0.0009 0.0013
Leishmania major protein kinase A catalytic subunit 0.0101 0.0194 0.077
Brugia malayi protein-tyrosine kinase 0.0093 0.0166 0.0231
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1183 0.3866 0.5472
Brugia malayi Histone deacetylase family protein 0.0171 0.043 0.0604
Plasmodium falciparum glycogen synthase kinase 3 0.0116 0.0246 0.1106
Echinococcus granulosus TGF beta receptor type 1 0.0093 0.0166 0.0236
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0141 0.0329 0.1483
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0548 0.1712 0.7784
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0249 0.0696 0.0985
Brugia malayi Protein kinase domain containing protein 0.0151 0.0363 0.051
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Brugia malayi casein kinase 1, delta 0.006 0.0054 0.0072
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0692 0.2198 0.8858
Loa Loa (eye worm) histone deacetylase 1 0.0221 0.0602 0.0848
Schistosoma mansoni protein kinase 0.0217 0.0588 0.0828
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0078 0.0345
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0097 0.0179 0.0254
Onchocerca volvulus 0.006 0.0054 0.0149
Echinococcus multilocularis Immunoglobulin 0.0095 0.0175 0.0248
Echinococcus granulosus Vam6:Vps39 protein 0.0074 0.0102 0.0145
Schistosoma mansoni histone deacetylase 4 5 0.0171 0.043 0.0604
Echinococcus granulosus casein kinase I delta 0.006 0.0054 0.0076
Echinococcus multilocularis histone deacetylase 6 0.0171 0.043 0.0609
Onchocerca volvulus 0.0074 0.0102 0.0311
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0097 0.0182 0.0253
Echinococcus multilocularis death associated protein kinase 1 0.082 0.2634 0.3728
Loa Loa (eye worm) AUR protein kinase 0.0561 0.1754 0.2479
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0213 0.0957
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Leishmania major histone deacetylase, putative 0.0221 0.0602 0.2416
Leishmania major protein kinase, putative 0.0561 0.1754 0.7064
Schistosoma mansoni protein kinase 0.0168 0.0422 0.0593
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0101 0.0194 0.077
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0485 0.0682
Mycobacterium tuberculosis Conserved hypothetical protein 0.0548 0.1712 0.0916
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0775 0.2481 1
Echinococcus granulosus twitchin 0.0145 0.0343 0.0485
Schistosoma mansoni protein kinase C mu 0.0097 0.0182 0.0253
Brugia malayi cell division control protein 2 homolog 0.0107 0.0213 0.0297
Echinococcus multilocularis epidermal growth factor receptor 0.1183 0.3866 0.5472
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0108 0.0218 0.0309
Schistosoma mansoni tyrosine kinase 0.1141 0.3722 0.5266
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0098 0.0184 0.0256
Trypanosoma cruzi casein kinase, delta isoform, putative 0.006 0.0054 0.0205
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0692 0.2198 1
Schistosoma mansoni tyrosine kinase 0.029 0.0835 0.1177
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0187 0.0485 0.0682
Schistosoma mansoni septate junction protein 0.0047 0.0009 0.0009
Echinococcus granulosus serine:threonine protein kinase N2 0.0047 0.001 0.0014
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0097 0.0179 0.0254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0037 0.0048
Echinococcus granulosus lachesin 0.0047 0.0009 0.0013
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.0243 0.0344
Echinococcus granulosus serine:threonine protein kinase 0.0062 0.0063 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0213 0.0297
Echinococcus multilocularis casein kinase I delta 0.006 0.0054 0.0076
Plasmodium falciparum calcium-dependent protein kinase 2 0.006 0.0053 0.0229
Brugia malayi Protein kinase domain containing protein 0.0047 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0099 0.0187 0.026
Brugia malayi Tyrosine-protein kinase abl-1 0.0249 0.0697 0.0982
Plasmodium falciparum calcium-dependent protein kinase 5 0.006 0.0053 0.0229
Brugia malayi Temporarily assigned gene name protein 59 0.0074 0.0102 0.014
Echinococcus granulosus roundabout 2 0.005 0.0021 0.003
Entamoeba histolytica protein kinase domain containing protein 0.0561 0.1754 0.7975
Plasmodium vivax histone deacetylase, putative 0.0171 0.043 0.1847
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0561 0.1754 0.7975
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0136 0.0312 0.0442
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0065 0.0072 0.0313
Brugia malayi casein kinase I 0.006 0.0054 0.0072
Plasmodium falciparum protein serine/threonine kinase-1 0.0141 0.0329 0.1483
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.043 0.1722
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Plasmodium falciparum serine/threonine protein kinase, putative 0.0561 0.1754 0.7974
Echinococcus granulosus tyrosine protein kinase Srms 0.0064 0.0069 0.0097
Schistosoma mansoni tyrosine kinase 0.1183 0.3866 0.547
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0561 0.1754 0.2482
Loa Loa (eye worm) hypothetical protein 0.0182 0.047 0.0661
Echinococcus granulosus Immunoglobulin 0.0095 0.0175 0.0248
Leishmania major protein kinase, putative 0.006 0.0053 0.0203
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0692 0.2198 0.8858
Echinococcus multilocularis calcium activated potassium channel 0.0053 0.003 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0213 0.0957
Brugia malayi Protein kinase domain containing protein 0.0053 0.003 0.0038
Plasmodium falciparum histone deacetylase 1 0.0221 0.0602 0.2727
Brugia malayi Histone deacetylase 1 0.0221 0.0602 0.0848
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0095 0.0175 0.0248
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0775 0.2481 0.3509
Trypanosoma cruzi histone deacetylase, putative 0.0088 0.0151 0.0596
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0168 0.0421 0.0591
Loa Loa (eye worm) hypothetical protein 0.0101 0.0194 0.027
Plasmodium falciparum calcium-dependent protein kinase 3 0.006 0.0053 0.0229
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0139 0.0323 0.0457
Echinococcus multilocularis cyclin dependent kinase 9 0.0067 0.0078 0.011
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0055 0.0037 0.0048
Trypanosoma cruzi cdc2-related kinase 1 0.0107 0.0213 0.0847
Schistosoma mansoni protein kinase 0.0168 0.0422 0.0593
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0031 0.0039
Echinococcus granulosus NDR protein kinase 0.0047 0.001 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Echinococcus multilocularis tyrosine protein kinase shark 0.0064 0.0069 0.0097
Loa Loa (eye worm) AUR protein kinase 0.0561 0.1754 0.2479
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0018 0.0074
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0139 0.0324 0.0458
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0323 0.0453
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0101 0.0194 0.027
Onchocerca volvulus 0.0064 0.0069 0.0199
Echinococcus multilocularis cyclin dependent kinase 1 0.0107 0.0213 0.0302
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0692 0.2198 0.3108
Echinococcus multilocularis activated cdc42 kinase 1 0.0205 0.0546 0.0772
Loa Loa (eye worm) hypothetical protein 0.0162 0.0402 0.0565
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0064 0.0069 0.0097
Echinococcus multilocularis mitogen activated protein kinase 14 0.0775 0.2481 0.3512
Brugia malayi Protein kinase domain containing protein 0.0314 0.0916 0.1293
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0208 0.0556 0.0783
Brugia malayi Protein kinase domain containing protein 0.0912 0.2945 0.4165
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0107 0.0213 0.0302
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0139 0.0323 0.0453
Trichomonas vaginalis STE family protein kinase 0.0168 0.0421 0.1902
Echinococcus granulosus c-Jun N-terminal kinases 0.0249 0.0696 0.0985
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0108 0.0218 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0019 0.0022
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0139 0.0324 0.0458
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.005 0.0021 0.003
Echinococcus multilocularis serine:threonine protein kinase 0.0062 0.0063 0.0089
Echinococcus multilocularis casein kinase i 0.006 0.0054 0.0076
Echinococcus multilocularis tyrosine protein kinase Blk 0.0093 0.0166 0.0235
Schistosoma mansoni tyrosine kinase 0.2126 0.7066 1
Brugia malayi Protein kinase domain containing protein 0.0083 0.0131 0.0182
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0813 0.2611 0.3695
Brugia malayi SH2 domain containing protein 0.0064 0.0069 0.0093
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0213 0.0297
Schistosoma mansoni tyrosine kinase 0.0196 0.0517 0.0727
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0047 0.001 0.0009
Schistosoma mansoni tyrosine kinase 0.0058 0.0047 0.0062
Schistosoma mansoni tyrosine kinase 0.1141 0.3722 0.5266
Onchocerca volvulus 0.0308 0.0898 0.2972
Brugia malayi Protein kinase domain containing protein 0.0179 0.0459 0.0645
Entamoeba histolytica serine/threonine protein kinase, putative 0.0045 0.0003 0.0004
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0141 0.0329 0.1314
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0692 0.2198 0.8858
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0031 0.0039
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0047 0.001 0.0014
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0067 0.0078 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.023 0.0321
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.005 0.0021 0.003
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0107 0.0213 0.0847
Entamoeba histolytica protein kinase , putative 0.0561 0.1754 0.7975
Trypanosoma cruzi cdc2-related kinase 1 0.0107 0.0213 0.0847
Echinococcus multilocularis mitogen activated protein kinase 14 0.0775 0.2481 0.3512
Echinococcus granulosus calcium activated potassium channel 0.0053 0.003 0.0042
Schistosoma mansoni atypical protein kinase C 0.0062 0.006 0.0081
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.006 0.0053 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0047 0.001 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0123 0.0269 0.121
Loa Loa (eye worm) hypothetical protein 0.0115 0.0243 0.0339
Leishmania major histone deacetylase, putative 0.0171 0.043 0.1722
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0101 0.0194 0.077
Trypanosoma brucei protein kinase, putative 0.0116 0.0246 0.0979
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0105 0.0207 0.0293
Loa Loa (eye worm) AGC/PKA protein kinase 0.0101 0.0194 0.027
Schistosoma mansoni kinase 0.007 0.0087 0.0119
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Echinococcus multilocularis serine:threonine protein kinase 0.0062 0.0063 0.0089
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0074 0.0102 0.0145
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.0459 0.0645
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0314 0.0916 0.1297
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0078 0.0106
Echinococcus granulosus contactin 0.005 0.0021 0.003
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0692 0.2198 1
Entamoeba histolytica hypothetical protein 0.0197 0.0521 0.2361
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.001 0.0014
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Echinococcus granulosus protein kinase C gamma type 0.0047 0.001 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0521 0.0733
Echinococcus multilocularis protein tyrosine kinase 0.029 0.0835 0.1181
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0036 0.0149
Echinococcus multilocularis twitchin 0.0049 0.0019 0.0027
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.005 0.0021 0.0026
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Loa Loa (eye worm) hypothetical protein 0.005 0.0021 0.0026
Echinococcus granulosus mitogen activated protein kinase 11 0.0775 0.2481 0.3512
Trichomonas vaginalis AGC family protein kinase 0.0047 0.001 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0109 0.0219 0.0306
Echinococcus multilocularis histone deacetylase 6 0.0171 0.043 0.0609
Onchocerca volvulus 0.0064 0.0069 0.0199
Brugia malayi Prion-like- 0.0047 0.0009 0.0009
Schistosoma mansoni roundabout 0.0047 0.0009 0.0009
Echinococcus multilocularis dual specificity 0.0197 0.0521 0.0737
Schistosoma mansoni tyrosine kinase 0.0105 0.0207 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.001 0.0009
Onchocerca volvulus 0.006 0.0054 0.015
Echinococcus granulosus rho-associated protein kinase 1 0.0308 0.0898 0.1271
Echinococcus multilocularis insulin receptor 0.081 0.2599 0.3678
Echinococcus granulosus neuroglian 0.005 0.0021 0.003
Leishmania major protein kinase A catalytic subunit isoform 2 0.0101 0.0194 0.077
Schistosoma mansoni septate junction protein 0.0047 0.0009 0.0009
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0095 0.0175 0.0243
Entamoeba histolytica protein kinase, putative 0.0197 0.0521 0.2361
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0083 0.0365
Toxoplasma gondii AGC kinase 0.0047 0.001 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0164 0.0228
Echinococcus multilocularis dual specificity protein kinase clk2 0.0141 0.0329 0.0465
Schistosoma mansoni neuroglian 0.005 0.0021 0.0026
Entamoeba histolytica PH domain containing protein kinase, putative 0.0104 0.0205 0.0925
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0151 0.0363 0.051
Loa Loa (eye worm) hypothetical protein 0.0197 0.0518 0.073
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0197 0.0521 0.2089
Brugia malayi hypothetical protein 0.0064 0.0069 0.0093
Echinococcus granulosus tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Loa Loa (eye worm) TK/ALK protein kinase 0.0545 0.1701 0.2404
Schistosoma mansoni titin 0.0053 0.0031 0.0039
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.0242 0.1094
Plasmodium vivax serine/threonine kinase-1, putative 0.0141 0.0329 0.138
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0136 0.0312 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0665 0.0937
Schistosoma mansoni tyrosine kinase 0.0064 0.0069 0.0093
Loa Loa (eye worm) TK/KIN16 protein kinase 0.076 0.243 0.3437
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.023 0.0321
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0548 0.1712 0.0916
Brugia malayi Furin-like cysteine rich region family protein 0.2126 0.7066 1
Echinococcus multilocularis tyrosine kinase 0.0064 0.0069 0.0097
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0246 0.1109
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.006 0.0053 0.0203
Loa Loa (eye worm) hypothetical protein 0.0096 0.0176 0.0245
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0072
Schistosoma mansoni kinase 0.0067 0.0078 0.0106
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0129 0.0289 0.0409
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.0242 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0047 0.001 0.003
Echinococcus granulosus defective proboscis extension response 0.0095 0.0175 0.0248
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0139 0.0323 0.0453
Brugia malayi Histone deacetylase family protein 0.0171 0.043 0.0604
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.006 0.0053 0.0071
Schistosoma mansoni vesicular amine transporter 0.0095 0.0175 0.0243
Echinococcus multilocularis serine threonine protein kinase 0.0047 0.001 0.0014
Schistosoma mansoni protein kinase 0.0561 0.1754 0.2479
Schistosoma mansoni tyrosine kinase 0.0089 0.0153 0.0212
Echinococcus granulosus casein kinase I alpha 0.006 0.0054 0.0076
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0197 0.0521 0.0733
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0108 0.0219 0.087
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.003 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0053 0.0229
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0075 0.0105 0.0144
Giardia lamblia Kinase, PLK 0.0115 0.0242 0.0982
Trypanosoma brucei histone deacetylase 1 0.0221 0.0602 0.2416
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0116 0.0246 0.0344
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.0242 0.0343
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0141 0.0329 0.1314
Brugia malayi bone morphogenetic protein type 1 receptor 0.0113 0.0233 0.0325
Echinococcus granulosus protein kinase shaggy 0.0116 0.0246 0.0348
Echinococcus multilocularis dual specificity mitogen activated protein 0.0168 0.0421 0.0595
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Entamoeba histolytica histone deacetylase, putative 0.0221 0.0602 0.273
Echinococcus multilocularis cyclin dependent kinase 1 0.0107 0.0213 0.0302
Brugia malayi Hr1 repeat family protein 0.0047 0.001 0.0009
Onchocerca volvulus 0.0116 0.0246 0.0791
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0112 0.023 0.0325
Entamoeba histolytica casein kinase, putative 0.006 0.0054 0.0235
Loa Loa (eye worm) TK/INSR protein kinase 0.081 0.2599 0.3675
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.008 0.0123 0.0174
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0692 0.2198 0.3108
Echinococcus multilocularis neuroglian 0.0122 0.0266 0.0376
Schistosoma mansoni tyrosine kinase 0.1183 0.3866 0.547
Entamoeba histolytica protein kinase, putative 0.0561 0.1754 0.7975
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Echinococcus multilocularis activin receptor type 0.0424 0.1289 0.1824
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0072
Schistosoma mansoni cell adhesion molecule 0.005 0.0021 0.0026
Giardia lamblia Kinase, AGC PKA 0.0101 0.0194 0.0759
Trypanosoma cruzi cdc2-related kinase 3 0.0107 0.0213 0.0847
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Brugia malayi histone deacetylase 11 0.0088 0.0151 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.021 0.0564 0.0798
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0053 0.0071
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0101 0.0194 0.077
Echinococcus granulosus activated cdc42 kinase 1 0.0205 0.0546 0.0772
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0148 0.0355 0.0498
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0054 0.0072
Schistosoma mansoni protein kinase 0.0314 0.0916 0.1293
Loa Loa (eye worm) CAMK protein kinase 0.0053 0.0031 0.0039
Schistosoma mansoni tyrosine kinase 0.081 0.2599 0.3675
Brugia malayi Protein kinase domain containing protein 0.005 0.0021 0.0025
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Trichomonas vaginalis STE family protein kinase 0.0124 0.0271 0.1219
Echinococcus multilocularis contactin neuroglian septate junction protein 0.005 0.0021 0.003
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0052 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0175 0.0444 0.0624
Schistosoma mansoni histone deacetylase 0.0221 0.0602 0.0848
Schistosoma mansoni tyrosine kinase 0.008 0.0121 0.0167
Brugia malayi Protein kinase domain containing protein 0.0928 0.2999 0.4242
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.006 0.0081
Onchocerca volvulus 0.0064 0.0069 0.0199
Loa Loa (eye worm) hypothetical protein 0.0074 0.0102 0.014
Schistosoma mansoni nephrin 0.005 0.0021 0.0026
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0062 0.0063 0.0085
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Brugia malayi hypothetical protein 0.0099 0.0187 0.026
Echinococcus granulosus protein tyrosine kinase 0.029 0.0835 0.1181
Onchocerca volvulus 0.0064 0.0069 0.0199
Schistosoma mansoni protein kinase 0.0113 0.0233 0.0325
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Echinococcus granulosus peroxidasin 0.0047 0.0011 0.0015
Plasmodium falciparum histone deacetylase, putative 0.0171 0.043 0.1945
Echinococcus multilocularis histone deacetylase 1 0.0221 0.0602 0.0852
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0124 0.0271 0.1112
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Brugia malayi hypothetical protein 0.006 0.0054 0.0072
Brugia malayi Tyrosine-protein kinase abl-1 0.0234 0.0645 0.0908
Echinococcus granulosus dual specificity mitogen activated protein 0.0168 0.0421 0.0595
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0074 0.0102 0.014
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0179 0.0459 0.0649
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.2991 1 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0184 0.0256
Onchocerca volvulus 0.0075 0.0105 0.0318
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0141 0.0329 0.1314
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.2991 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0129 0.0289 0.0404
Onchocerca volvulus Histone deacetylase 10 homolog 0.0088 0.0151 0.0473
Onchocerca volvulus 0.0064 0.0069 0.0199
Trypanosoma brucei histone deacetylase, putative 0.0171 0.043 0.1722
Onchocerca volvulus 0.0064 0.0069 0.0199
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0108 0.0218 0.0309
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0217 0.0588 0.0832
Echinococcus multilocularis lachesin 0.0047 0.0009 0.0013
Loa Loa (eye worm) AGC/NDR protein kinase 0.0047 0.001 0.0009
Brugia malayi Protein kinase domain containing protein 0.0062 0.0063 0.0085
Giardia lamblia Kinase, STE STE20 0.0168 0.0421 0.1804
Echinococcus multilocularis protein kinase c epsilon type 0.0062 0.006 0.0085
Plasmodium vivax glycogen synthase kinase 3, putative 0.0116 0.0246 0.0998
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0064 0.0069 0.0097
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0108 0.0218 0.0309
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0179 0.0459 0.1503
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0062 0.006 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.0696 0.0981
Brugia malayi Protein kinase domain containing protein 0.0293 0.0845 0.1191
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0101 0.0194 0.077
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0775 0.2481 1
Schistosoma mansoni tyrosine kinase 0.1141 0.3722 0.5266
Echinococcus granulosus cyclin dependent kinase 7 0.0098 0.0184 0.026
Brugia malayi Protein kinase domain containing protein 0.0545 0.1701 0.2405
Giardia lamblia Kinase, CMGC CDK 0.0107 0.0213 0.0847
Schistosoma mansoni vam6/vps39 related 0.0074 0.0102 0.014
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0021 0.0026
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.001 0.0014
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0561 0.1754 0.7975
Brugia malayi histone deacetylase 3 (HD3) 0.0221 0.0602 0.0848
Loa Loa (eye worm) hypothetical protein 0.0175 0.0444 0.0624
Schistosoma mansoni histone deacetylase 4 5 0.0171 0.043 0.0604
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0082 0.013 0.018
Schistosoma mansoni protein kinase 0.0168 0.0421 0.0591
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0775 0.2481 1
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0168 0.0421 0.1685
Brugia malayi Protein kinase domain containing protein 0.0205 0.0546 0.0768
Echinococcus granulosus tyrosine protein kinase Src42A 0.0052 0.0028 0.0039
Echinococcus multilocularis casein kinase I delta 0.006 0.0054 0.0076
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.2154 0.3048
Mycobacterium tuberculosis Conserved hypothetical protein 0.0548 0.1712 0.0916
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0054 0.0231
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0561 0.1754 0.795
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0083 0.0365
Brugia malayi Immunoglobulin I-set domain containing protein 0.076 0.243 0.3437
Loa Loa (eye worm) hypothetical protein 0.0063 0.0063 0.0085
Trypanosoma brucei aurora B kinase 0.0561 0.1754 0.7064
Schistosoma mansoni ephrin receptor 0.0046 0.0007 0.0005
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0101 0.0194 0.0759
Echinococcus multilocularis roundabout 2 0.005 0.0021 0.003
Echinococcus granulosus titin 0.0053 0.0031 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Schistosoma mansoni serine/threonine protein kinase 0.0308 0.0898 0.1267
Loa Loa (eye worm) hypothetical protein 0.0084 0.0136 0.0188
Schistosoma mansoni protein kinase 0.0168 0.0422 0.0593
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.0459 0.0645
Giardia lamblia Kinase, CMGC GSK 0.0116 0.0246 0.0998
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0164 0.0228
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0054 0.0072
Echinococcus granulosus histone deacetylase 8 0.0088 0.0151 0.0214
Schistosoma mansoni protein kinase 0.0156 0.0379 0.0532
Schistosoma mansoni cell adhesion molecule 0.0119 0.0255 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0184 0.0256
Onchocerca volvulus 0.0602 0.1895 0.6308
Giardia lamblia Kinase, CMGC CLK 0.0141 0.0329 0.138
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0074 0.0102 0.04
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0246 0.1109
Loa Loa (eye worm) TK/EGFR protein kinase 0.2126 0.7066 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0333 0.0468
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0099 0.0136
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0072 0.0278
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0136 0.0312 0.0437
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.0242 0.0966
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Echinococcus granulosus insulin receptor 0.081 0.2599 0.3678
Loa Loa (eye worm) histone deacetylase 3 0.0221 0.0602 0.0848
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0072 0.0278
Loa Loa (eye worm) histone deacetylase 11 0.0088 0.0151 0.0209
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0108 0.0218 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0054 0.0072
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0069 0.0085 0.0121
Plasmodium vivax protein kinase Crk2 0.0107 0.0213 0.0847
Toxoplasma gondii histone deacetylase HDAC5 0.0088 0.0151 0.0673
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0136 0.0312 0.0442
Brugia malayi Protein kinase domain containing protein 0.0113 0.0233 0.0325
Echinococcus granulosus casein kinase I delta 0.006 0.0054 0.0076
Loa Loa (eye worm) histone deacetylase 7A 0.0171 0.043 0.0604
Echinococcus granulosus serine:threonine protein kinase 0.0062 0.0063 0.0089
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0692 0.2198 0.3111
Echinococcus granulosus cyclin dependent kinase 0.0107 0.0213 0.0302
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.006 0.0053 0.0111
Trypanosoma brucei polo-like protein kinase 0.0115 0.0242 0.0966
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0101 0.0194 0.0869
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0116 0.0246 0.0979
Toxoplasma gondii histone deacetylase HDAC1 0.0171 0.043 0.1945
Trichomonas vaginalis STE family protein kinase 0.0168 0.0421 0.1902
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.2154 0.3045
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Entamoeba histolytica protein kinase, putative 0.0071 0.0092 0.0409
Echinococcus multilocularis tyrosine protein kinase HCK 0.0071 0.0092 0.013
Giardia lamblia Kinase, NEK 0.0124 0.0271 0.1112
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.043 0.1722
Echinococcus granulosus histone deacetylase 6 0.0171 0.043 0.0609
Plasmodium vivax calcium-dependent protein kinase, putative 0.006 0.0053 0.0111
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0208 0.0556 0.0787
Echinococcus multilocularis transfer RNA-Thr 0.0205 0.0546 0.0772
Echinococcus granulosus histone deacetylase 1 0.0221 0.0602 0.0852
Loa Loa (eye worm) hypothetical protein 0.0133 0.0302 0.0423
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0078 0.0117 0.0165
Echinococcus granulosus serine:threonine kinase SAD 1 0.0045 0.0003 0.0004
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Trypanosoma brucei casein kinase I, isoform 2 0.006 0.0054 0.0205
Echinococcus granulosus tyrosine protein kinase Blk 0.0093 0.0166 0.0235
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0109 0.0219 0.0306
Echinococcus granulosus epidermal growth factor receptor 0.2126 0.7066 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.0602 0.0848
Schistosoma mansoni rap gtpase-activating protein 0.0074 0.0102 0.014
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0133 0.0302 0.0427
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0141 0.0329 0.1314
Brugia malayi Stress-activated protein kinase jnk-1 0.0249 0.0696 0.0981
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.003 0.0121
Echinococcus multilocularis epidermal growth factor receptor 0.2126 0.7066 1
Echinococcus granulosus histone deacetylase 6 0.0171 0.043 0.0609
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0073 0.0099 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.001 0.0009
Leishmania major protein kinase, putative 0.0065 0.0072 0.0278
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0129 0.0289 0.0409
Leishmania major protein kinase, putative 0.0141 0.0329 0.1314
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0314 0.0916 0.1297
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0021 0.0026
Echinococcus granulosus microtubule associated protein 2 0.0679 0.2154 0.3048
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.0242 0.078
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0221 0.0602 0.2727
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Entamoeba histolytica protein kinase, putative 0.005 0.0021 0.0085
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0083 0.0131 0.0182
Trypanosoma brucei histone deacetylase 3 0.0171 0.043 0.1722
Giardia lamblia Kinase, NEK 0.0124 0.0271 0.1112
Entamoeba histolytica protein kinase, putative 0.005 0.0021 0.0085
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Schistosoma mansoni serine/threonine kinase 0.0047 0.001 0.0009
Brugia malayi Cam kinase protein 1 0.006 0.0053 0.0071
Schistosoma mansoni protein kinase 0.006 0.0054 0.0072
Echinococcus granulosus mitogen activated protein kinase 14 0.0775 0.2481 0.3512
Brugia malayi C1-like domain containing protein 0.0097 0.0182 0.0253
Brugia malayi Immunoglobulin I-set domain containing protein 0.0166 0.0414 0.0582
Plasmodium vivax histone deacetylase 1, putative 0.0221 0.0602 0.2639
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0101 0.0194 0.0869
Loa Loa (eye worm) AGC/PKA protein kinase 0.0101 0.0194 0.027
Echinococcus multilocularis casein kinase I alpha 0.006 0.0054 0.0076
Echinococcus granulosus protein kinase c epsilon type 0.0062 0.006 0.0085
Echinococcus granulosus activin receptor type 0.0424 0.1289 0.1824
Loa Loa (eye worm) hypothetical protein 0.0142 0.0333 0.0468
Trypanosoma brucei histone deacetylase 4 0.0171 0.043 0.1722
Loa Loa (eye worm) hypothetical protein 0.0475 0.1463 0.2067
Echinococcus multilocularis cyclin dependent kinase 19 0.0151 0.0363 0.0514
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0047 0.001 0.0014
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0116 0.0246 0.0344
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0097 0.0182 0.0253
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0141 0.0329 0.1314
Brugia malayi Protein kinase domain containing protein 0.0187 0.0485 0.0682
Brugia malayi Protein kinase domain containing protein 0.0107 0.0213 0.0297
Echinococcus granulosus histone deacetylase 7 0.0171 0.043 0.0609
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0009 0.0009
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0116 0.0246 0.1106
Echinococcus granulosus tyrosine protein kinase ABL1 0.0468 0.1438 0.2036
Schistosoma mansoni protein kinase 0.0217 0.0588 0.0828
Echinococcus multilocularis hemicentin 1 0.0047 0.0009 0.0013
Entamoeba histolytica tyrosin kinase, putative 0.0049 0.0018 0.0074
Echinococcus multilocularis histone deacetylase 3 0.0221 0.0602 0.0852
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0912 0.2945 0.4165
Echinococcus multilocularis tyrosine protein kinase Srms 0.0093 0.0166 0.0235
Echinococcus granulosus roundabout 2 0.0146 0.0345 0.0489
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0107 0.0213 0.0847
Echinococcus granulosus tyrosine protein kinase Btk29A 0.021 0.0564 0.0798
Trichomonas vaginalis STE family protein kinase 0.0168 0.0421 0.1902
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0074 0.0102 0.04
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0054 0.0231
Onchocerca volvulus 0.0078 0.0116 0.0357
Leishmania major casein kinase, putative 0.006 0.0054 0.0205
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0116 0.0246 0.0344
Schistosoma mansoni histone deacetylase 0.0221 0.0602 0.0848
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0063 0.0272
Leishmania major protein kinase A catalytic subunit isoform 1 0.0101 0.0194 0.077
Loa Loa (eye worm) hypothetical protein 0.0064 0.0069 0.0093
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0468 0.1438 0.2036
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0141 0.0329 0.0461
Trypanosoma cruzi cdc2-related kinase 3 0.0107 0.0213 0.0847
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Toxoplasma gondii AGC kinase 0.0101 0.0194 0.0869
Leishmania major histone deacetylase, putative 0.0221 0.0602 0.2416
Echinococcus multilocularis rho associated protein kinase 0.0308 0.0898 0.1271
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0064 0.0069 0.0303
Loa Loa (eye worm) hypothetical protein 0.0136 0.0312 0.0437
Loa Loa (eye worm) TK protein kinase 0.0166 0.0414 0.0582
Brugia malayi serine/threonine kinase 12 0.0561 0.1754 0.2479
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Brugia malayi Fibronectin type III domain containing protein 0.0099 0.0187 0.026
Schistosoma mansoni protein kinase 0.0093 0.0166 0.0231
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0194 0.0869
Loa Loa (eye worm) hypothetical protein 0.0205 0.0546 0.0768
Plasmodium falciparum casein kinase 1 0.006 0.0054 0.0231
Brugia malayi protein C17H12.11 0.006 0.0054 0.0072
Toxoplasma gondii AGC kinase 0.0101 0.0194 0.0869
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0692 0.2198 1
Schistosoma mansoni serine/threonine protein kinase 0.0561 0.1754 0.2479
Brugia malayi Protein kinase domain containing protein 0.081 0.2599 0.3675
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0329 0.0461
Echinococcus multilocularis 0.0082 0.0128 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Treponema pallidum licC protein (licC) 0.0548 0.1712 0.5
Schistosoma mansoni cell adhesion molecule 0.005 0.0021 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.005 0.0021 0.003
Loa Loa (eye worm) AGC/AKT protein kinase 0.005 0.0021 0.0025
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0107 0.0213 0.0957
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.2991 1 1
Echinococcus granulosus roundabout 2 0.005 0.0021 0.003
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Echinococcus granulosus casein kinase i 0.006 0.0054 0.0076
Echinococcus granulosus tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.006 0.0053 0.0071
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Loa Loa (eye worm) hypothetical protein 0.007 0.0089 0.0122
Echinococcus multilocularis histone deacetylase 0.0171 0.043 0.0609
Echinococcus granulosus histone deacetylase 3 0.0221 0.0602 0.0852
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0363 0.051
Brugia malayi serine/threonine-protein kinase PAK 7 0.0202 0.0537 0.0756
Loa Loa (eye worm) TK/ROR protein kinase 0.0069 0.0085 0.0116
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Schistosoma mansoni cell adhesion molecule 0.0047 0.0009 0.0009
Echinococcus granulosus raf serine:threonine protein kinase 0.0057 0.0045 0.0064
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0107 0.0213 0.0297
Brugia malayi cyclin-dependent kinase 9 0.0067 0.0078 0.0106
Echinococcus granulosus hypothetical protein 0.0118 0.0251 0.0356
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Schistosoma mansoni histone deacetylase hda2 0.0171 0.043 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.006 0.0081
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0217 0.0588 0.0832
Echinococcus granulosus protein kinase c iota type 0.0062 0.006 0.0085
Entamoeba histolytica protein kinase, putative 0.006 0.0053 0.0233
Schistosoma mansoni histone deacetylase 1 2 3 0.0088 0.0151 0.0209
Brugia malayi Protein kinase domain containing protein 0.0047 0.001 0.0009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Loa Loa (eye worm) hypothetical protein 0.0118 0.0251 0.0352
Loa Loa (eye worm) hypothetical protein 0.0063 0.0063 0.0085
Echinococcus multilocularis serine:threonine protein kinase 38 0.0047 0.001 0.0014
Plasmodium falciparum calcium-dependent protein kinase 4 0.006 0.0053 0.0229
Loa Loa (eye worm) hypothetical protein 0.0136 0.0312 0.0437
Echinococcus multilocularis c src tyrosine kinase 0.008 0.0121 0.0171
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0168 0.0421 0.1685
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0194 0.027
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0093 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0088 0.0151 0.0209
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0074 0.0102 0.0145
Plasmodium falciparum protein kinase, putative 0.0065 0.0072 0.0313
Echinococcus multilocularis titin 0.0053 0.0031 0.0044
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0078 0.0117 0.0165
Entamoeba histolytica protein kinase, putative 0.0197 0.0521 0.2361
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0202 0.0537 0.0756
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0074 0.0102 0.014
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Echinococcus granulosus fibroblast growth factor receptor 4 0.0139 0.0324 0.0458
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Onchocerca volvulus 0.0928 0.2999 1
Schistosoma mansoni tyrosine kinase 0.0108 0.0218 0.0305
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0194 0.027
Plasmodium falciparum calcium-dependent protein kinase 1 0.006 0.0053 0.0229
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0329 0.0461
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0213 0.0297
Trichomonas vaginalis AGC family protein kinase 0.0124 0.0271 0.1219
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.006 0.0053 0.0071
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0072 0.0317
Echinococcus granulosus cyclin dependent kinase 5 0.0107 0.0213 0.0302
Plasmodium vivax histone deacetylase, putative 0.0088 0.0151 0.056
Brugia malayi intracellular kinase 0.0116 0.0246 0.0344
Loa Loa (eye worm) AUR protein kinase 0.0561 0.1754 0.2479
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.008 0.0123 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0289 0.0404
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0045 0.0059
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.043 0.1722
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0355 0.0498
Loa Loa (eye worm) TKL/LRRK protein kinase 0.008 0.0123 0.017
Echinococcus multilocularis 0.0118 0.0251 0.0356
Brugia malayi Protein kinase domain containing protein 0.008 0.0123 0.017
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0113 0.0233 0.0325
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0139 0.0323 0.0457
Loa Loa (eye worm) hypothetical protein 0.0074 0.0102 0.014
Schistosoma mansoni tyrosine kinase 0.008 0.0121 0.0167
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0116 0.0246 0.0348
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0101 0.0194 0.077
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.006 0.0081
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0108 0.0218 0.0309
Toxoplasma gondii casein kinase I 0.006 0.0054 0.0231
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Onchocerca volvulus 0.0053 0.0031 0.0072
Echinococcus granulosus dual specificity 0.0197 0.0521 0.0737
Echinococcus multilocularis histone deacetylase 6 0.0171 0.043 0.0609
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0116 0.0246 0.0979
Echinococcus multilocularis cyclin dependent kinase 5 0.0107 0.0213 0.0302
Echinococcus granulosus tyrosine kinase 0.0064 0.0069 0.0097
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0168 0.0422 0.0597
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0168 0.0422 0.0597
Leishmania major protein kinase, putative 0.0141 0.0329 0.1314
Loa Loa (eye worm) histone deacetylase 0.0171 0.043 0.0604
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0112 0.023 0.0325
Echinococcus granulosus dual specificity protein kinase clk2 0.0141 0.0329 0.0465
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0362 0.0508
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0101 0.0194 0.077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0011 0.0011
Loa Loa (eye worm) TK/ABL protein kinase 0.0468 0.1438 0.2032
Echinococcus multilocularis protein kinase c iota type 0.0062 0.006 0.0085
Entamoeba histolytica protein kinase, putative 0.0047 0.001 0.0033
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0072 0.0278
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0047 0.001 0.0009
Giardia lamblia Kinase, CK1 Casein kinase 0.006 0.0054 0.0113
Brugia malayi protein unc-22 0.0053 0.0031 0.0039
Toxoplasma gondii histone deacetylase HDAC4 0.0088 0.0151 0.0673
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.003 0.0038
Schistosoma mansoni protein kinase 0.0065 0.0072 0.0097
Toxoplasma gondii histone deacetylase HDAC3 0.0221 0.0602 0.2727
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0053 0.003 0.0038
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0047 0.001 0.0014
Schistosoma mansoni tyrosine kinase 0.0108 0.0218 0.0305
Echinococcus granulosus tyrosine protein kinase Lyn 0.0131 0.0295 0.0418
Schistosoma mansoni titin 0.0047 0.0009 0.0009
Plasmodium falciparum NIMA related kinase 1 0.0124 0.0271 0.1219
Echinococcus multilocularis histone deacetylase 8 0.0088 0.0151 0.0214
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0047 0.0009 0.0013
Echinococcus multilocularis TGF beta receptor type 1 0.0093 0.0166 0.0236
Echinococcus granulosus neuroglian 0.0122 0.0266 0.0376
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0074 0.0102 0.04
Echinococcus multilocularis casein kinase I alpha 0.006 0.0054 0.0076
Entamoeba histolytica protein kinase, putative 0.006 0.0053 0.0233
Loa Loa (eye worm) hypothetical protein 0.0074 0.0102 0.014
Loa Loa (eye worm) hypothetical protein 0.0099 0.0187 0.026
Echinococcus multilocularis cyclin dependent kinase 7 0.0098 0.0184 0.026
Loa Loa (eye worm) TK protein kinase 0.0071 0.0092 0.0126
Echinococcus granulosus titin 0.0053 0.0031 0.0044
Brugia malayi P38 map kinase family protein 2 0.0775 0.2481 0.3509
Giardia lamblia Kinase, CMGC CDK 0.0107 0.0213 0.0847
Echinococcus granulosus c src tyrosine kinase 0.008 0.0121 0.0171
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0116 0.0246 0.0348
Echinococcus granulosus tyrosine protein kinase Src64B 0.0108 0.0218 0.0309
Brugia malayi Peroxidasin 0.0047 0.0011 0.0011
Schistosoma mansoni nephrin 0.0126 0.0278 0.0389
Entamoeba histolytica protein kinase, putative 0.0116 0.0246 0.1109
Echinococcus granulosus protein kinase 0.0082 0.0128 0.0181
Loa Loa (eye worm) hypothetical protein 0.0062 0.0063 0.0085
Echinococcus multilocularis roundabout 2 0.005 0.0021 0.003
Onchocerca volvulus Tyrosine kinase homolog 0.0671 0.2129 0.7092
Plasmodium vivax casein kinase 1, putative 0.006 0.0054 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0242 0.0339
Toxoplasma gondii histone deacetylase HDAC2 0.0221 0.0602 0.2727
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0242 0.0966
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0093 0.0166 0.0235
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0813 0.2611 0.3695
Onchocerca volvulus 0.0136 0.0312 0.1011
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.003 0.0038
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0124 0.0271 0.1219
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.005 0.0021 0.0026
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0179 0.0459 0.0645
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0561 0.1754 0.2482
Echinococcus granulosus epidermal growth factor receptor 0.1183 0.3866 0.5472
Entamoeba histolytica cell division protein kinase 2, putative 0.0107 0.0213 0.096
Loa Loa (eye worm) TK/FAK protein kinase 0.0293 0.0845 0.1191
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0168 0.0421 0.0591
Leishmania major histone deacetylase, putative 0.0171 0.043 0.1722
Echinococcus granulosus casein kinase I alpha 0.006 0.0054 0.0076
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Echinococcus multilocularis mitogen activated protein kinase 11 0.0775 0.2481 0.3512
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0069 0.0085 0.0121
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0082 0.0128 0.0176
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0449 0.1376 0.1948
Echinococcus multilocularis tyrosine protein kinase Abl 0.0234 0.0645 0.0912
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Echinococcus granulosus casein kinase I alpha 0.006 0.0054 0.0076
Echinococcus granulosus cyclin dependent kinase 1 0.0107 0.0213 0.0302
Echinococcus granulosus histone deacetylase 0.0171 0.043 0.0609
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0249 0.0696 0.0981
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.006 0.0053 0.0111
Trypanosoma brucei cdc2-related kinase 3 0.0107 0.0213 0.0847
Giardia lamblia Kinase, AGC AKT 0.0105 0.0207 0.0821
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0139 0.0324 0.0458
Echinococcus multilocularis neuroglian 0.005 0.0021 0.003
Brugia malayi SRC-1 0.0108 0.0218 0.0305
Echinococcus multilocularis protein kinase shaggy 0.0116 0.0246 0.0348
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0054 0.0231
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0556 0.0783
Echinococcus multilocularis Immunoglobulin 0.0095 0.0175 0.0248
Entamoeba histolytica protein kinase, putative 0.0047 0.001 0.0033
Echinococcus multilocularis cyclin dependent kinase 0.0107 0.0213 0.0302
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0168 0.0421 0.1685
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0197 0.0521 0.2089
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0221 0.0602 0.2727
Trypanosoma cruzi histone deacetylase 1, putative 0.0221 0.0602 0.2416
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0136 0.0312 0.0437
Trypanosoma cruzi histone deacetylase 1, putative 0.0221 0.0602 0.2416
Loa Loa (eye worm) TK protein kinase 0.0093 0.0166 0.0231
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 12 ml/min.kg Hepatic clearance in human hepatocytes after 1 to 4 hrs by LC/MS/MS analysis ChEMBL. 23659214
EC50 (binding) = 84 nM Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins ChEMBL. 23659214
EC50 (binding) = 1600 nM Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins in presence of whole blood ChEMBL. 23659214
EC50 (binding) = 2900 nM Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins ChEMBL. 23659214
Ki (binding) = 1.8 nM Inhibition of recombinant JAK1 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins in presence of ATP ChEMBL. 23659214
Ki (binding) = 44 nM Inhibition of recombinant JAK2 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins in presence of ATP ChEMBL. 23659214
Ratio EC50 (binding) = 19 Ratio of EC50 for JAK1 in human TF1 cells in presence of whole blood to EC50 for JAK1 in human TF1 cells in absence of whole blood ChEMBL. 23659214

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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