Detailed information for compound 1777834

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.383 | Formula: C17H22N4O
  • H donors: 2 H acceptors: 3 LogP: 2.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@H](c1nc2c(n1C1CCCCC1)c1cc[nH]c1nc2)O
  • InChi: 1S/C17H22N4O/c1-2-14(22)17-20-13-10-19-16-12(8-9-18-16)15(13)21(17)11-6-4-3-5-7-11/h8-11,14,22H,2-7H2,1H3,(H,18,19)/t14-/m1/s1
  • InChiKey: HHCLTHAKVRSHMV-CQSZACIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Janus kinase 1 Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Serine/threonine-protein kinase SULU 0.0208 0.0556 0.0783
Loa Loa (eye worm) hypothetical protein 0.0175 0.0444 0.0624
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0141 0.0329 0.1314
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0054 0.0072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Echinococcus granulosus neuroglian 0.005 0.0021 0.003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Giardia lamblia Kinase, PLK 0.0115 0.0242 0.0982
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0093 0.0166 0.0236
Trypanosoma cruzi cdc2-related kinase 1 0.0107 0.0213 0.0847
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0242 0.0966
Entamoeba histolytica protein kinase, putative 0.006 0.0053 0.0233
Entamoeba histolytica tyrosin kinase, putative 0.0049 0.0018 0.0074
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Echinococcus multilocularis mitogen activated protein kinase 11 0.0775 0.2481 0.3512
Entamoeba histolytica protein kinase, putative 0.0071 0.0092 0.0409
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0775 0.2481 1
Echinococcus granulosus contactin 0.005 0.0021 0.003
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.005 0.0021 0.003
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0047 0.001 0.0009
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0047 0.001 0.0014
Schistosoma mansoni tyrosine kinase 0.0196 0.0517 0.0727
Brugia malayi Protein kinase domain containing protein 0.0293 0.0845 0.1191
Echinococcus multilocularis 0.0692 0.2198 0.3111
Trichomonas vaginalis AGC family protein kinase 0.0047 0.001 0.003
Schistosoma mansoni protein kinase 0.0065 0.0072 0.0097
Entamoeba histolytica protein kinase, putative 0.0197 0.0521 0.2361
Plasmodium falciparum calcium-dependent protein kinase 4 0.006 0.0053 0.0229
Toxoplasma gondii histone deacetylase HDAC3 0.0221 0.0602 0.2727
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0289 0.0404
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0108 0.0218 0.0309
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Echinococcus multilocularis protein tyrosine kinase 0.029 0.0835 0.1181
Brugia malayi Stress-activated protein kinase jnk-1 0.0249 0.0696 0.0981
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0083 0.0131 0.0182
Brugia malayi SRC-1 0.0108 0.0218 0.0305
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0101 0.0194 0.077
Plasmodium falciparum histone deacetylase 1 0.0221 0.0602 0.2727
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0561 0.1754 0.7975
Onchocerca volvulus Histone deacetylase 10 homolog 0.0088 0.0151 0.0473
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.006 0.0053 0.0111
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0148 0.0355 0.0498
Loa Loa (eye worm) histone deacetylase 11 0.0088 0.0151 0.0209
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0136 0.0312 0.0437
Onchocerca volvulus 0.006 0.0054 0.0149
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0107 0.0213 0.0847
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Trypanosoma cruzi cdc2-related kinase 3 0.0107 0.0213 0.0847
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.006 0.0053 0.0071
Echinococcus granulosus hemicentin 1 0.0047 0.0009 0.0013
Echinococcus granulosus tyrosine protein kinase Lyn 0.0131 0.0295 0.0418
Loa Loa (eye worm) hypothetical protein 0.0099 0.0187 0.026
Echinococcus granulosus histone deacetylase 0.0171 0.043 0.0609
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0064 0.0069 0.0097
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0054 0.0231
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0129 0.0289 0.0404
Loa Loa (eye worm) SRC-1 0.0108 0.0218 0.0305
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0074 0.0102 0.014
Loa Loa (eye worm) hypothetical protein 0.0063 0.0063 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.023 0.0321
Entamoeba histolytica protein kinase , putative 0.0561 0.1754 0.7975
Echinococcus multilocularis 0.0647 0.2048 0.2899
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0775 0.2481 0.3509
Toxoplasma gondii AGC kinase 0.0101 0.0194 0.0869
Plasmodium vivax glycogen synthase kinase 3, putative 0.0116 0.0246 0.0998
Echinococcus multilocularis activin receptor type 0.0424 0.1289 0.1824
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0129 0.0289 0.0409
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0139 0.0324 0.0458
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0109 0.0219 0.0306
Brugia malayi histone deacetylase 11 0.0088 0.0151 0.0209
Echinococcus granulosus serine:threonine kinase SAD 1 0.0045 0.0003 0.0004
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0116 0.0246 0.0344
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0083 0.0365
Schistosoma mansoni tyrosine kinase 0.2126 0.7066 1
Brugia malayi cyclin-dependent kinase 9 0.0067 0.0078 0.0106
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Giardia lamblia Kinase, NEK 0.0124 0.0271 0.1112
Entamoeba histolytica hypothetical protein 0.0197 0.0521 0.2361
Echinococcus granulosus tyrosine protein kinase otk 0.0047 0.0009 0.0013
Leishmania major protein kinase A catalytic subunit isoform 2 0.0101 0.0194 0.077
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0213 0.0297
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0124 0.0271 0.1112
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0083 0.0365
Brugia malayi Hr1 repeat family protein 0.0047 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0063 0.0063 0.0085
Echinococcus granulosus dual specificity 0.0197 0.0521 0.0737
Schistosoma mansoni atypical protein kinase C 0.0062 0.006 0.0081
Echinococcus multilocularis dual specificity 0.0197 0.0521 0.0737
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0139 0.0324 0.0458
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0813 0.2611 0.3695
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.005 0.0021 0.003
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0548 0.1712 0.0916
Brugia malayi hypothetical protein 0.0099 0.0187 0.026
Echinococcus multilocularis calcium activated potassium channel 0.0053 0.003 0.0042
Brugia malayi Protein kinase domain containing protein 0.0205 0.0546 0.0768
Schistosoma mansoni tyrosine kinase 0.1141 0.3722 0.5266
Brugia malayi Tyrosine-protein kinase abl-1 0.0249 0.0697 0.0982
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0187 0.0485 0.0686
Brugia malayi Protein kinase domain containing protein 0.0197 0.0521 0.0733
Loa Loa (eye worm) hypothetical protein 0.0136 0.0312 0.0437
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0047 0.0009 0.0013
Echinococcus granulosus tyrosine protein kinase Srms 0.0064 0.0069 0.0097
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0053 0.003 0.0038
Brugia malayi Protein kinase domain containing protein 0.0047 0.001 0.0009
Echinococcus granulosus Immunoglobulin 0.0095 0.0175 0.0248
Schistosoma mansoni tyrosine kinase 0.008 0.0121 0.0167
Loa Loa (eye worm) TK protein kinase 0.0166 0.0414 0.0582
Schistosoma mansoni roundabout 0.0047 0.0009 0.0009
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.006 0.0053 0.0229
Onchocerca volvulus 0.0074 0.0102 0.0311
Loa Loa (eye worm) AGC/PKN protein kinase 0.0047 0.001 0.0009
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0072 0.0278
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0692 0.2198 0.8858
Schistosoma mansoni protein kinase 0.0093 0.0166 0.0231
Entamoeba histolytica protein kinase, putative 0.0047 0.001 0.0033
Brugia malayi Peroxidasin 0.0047 0.0011 0.0011
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Entamoeba histolytica protein kinase domain containing protein 0.0197 0.0521 0.2361
Schistosoma mansoni serine/threonine kinase 0.006 0.0056 0.0075
Brugia malayi Protein kinase domain containing protein 0.0928 0.2999 0.4242
Echinococcus granulosus titin 0.0053 0.0031 0.0044
Giardia lamblia Kinase, AGC PKA 0.0101 0.0194 0.0759
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0249 0.0696 0.0981
Plasmodium falciparum protein kinase 5 0.0107 0.0213 0.0957
Schistosoma mansoni tyrosine kinase 0.0139 0.0324 0.0454
Echinococcus multilocularis histone deacetylase 7 0.0171 0.043 0.0609
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0221 0.0602 0.2727
Entamoeba histolytica protein kinase, putative 0.0561 0.1754 0.7975
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0468 0.1438 0.2036
Schistosoma mansoni protein kinase 0.0217 0.0588 0.0828
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0213 0.0297
Schistosoma mansoni serine/threonine protein kinase 0.0561 0.1754 0.2479
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0213 0.0297
Echinococcus multilocularis lachesin 0.0047 0.0009 0.0013
Onchocerca volvulus 0.0602 0.1895 0.6308
Giardia lamblia Histone deacetylase 0.0221 0.0602 0.2639
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0074 0.0102 0.04
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0141 0.0329 0.1314
Loa Loa (eye worm) CAMK protein kinase 0.0053 0.0031 0.0039
Entamoeba histolytica protein kinase, putative 0.005 0.0021 0.0085
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Echinococcus multilocularis roundabout 2 0.005 0.0021 0.003
Brugia malayi Protein kinase domain containing protein 0.008 0.0123 0.017
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.0242 0.0339
Brugia malayi histone deacetylase 3 (HD3) 0.0221 0.0602 0.0848
Echinococcus multilocularis c src tyrosine kinase 0.008 0.0121 0.0171
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Schistosoma mansoni tyrosine kinase 0.0089 0.0153 0.0212
Loa Loa (eye worm) AUR protein kinase 0.0561 0.1754 0.2479
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0329 0.0461
Plasmodium vivax serine/threonine kinase-1, putative 0.0141 0.0329 0.138
Echinococcus multilocularis histone deacetylase 6 0.0171 0.043 0.0609
Loa Loa (eye worm) AGC/NDR protein kinase 0.0047 0.001 0.0009
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0136 0.0312 0.0442
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0045 0.0059
Echinococcus granulosus roundabout 2 0.005 0.0021 0.003
Plasmodium falciparum glycogen synthase kinase 3 0.0116 0.0246 0.1106
Toxoplasma gondii AGC kinase 0.0101 0.0194 0.0869
Trypanosoma brucei histone deacetylase, putative 0.0171 0.043 0.1722
Echinococcus granulosus protein kinase shaggy 0.0116 0.0246 0.0348
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0124 0.0271 0.1219
Trypanosoma cruzi histone deacetylase 1, putative 0.0221 0.0602 0.2416
Trypanosoma brucei protein kinase, putative 0.0065 0.0072 0.0278
Brugia malayi serine/threonine-protein kinase 6 0.0561 0.1754 0.2479
Echinococcus multilocularis serine:threonine protein kinase 38 0.0047 0.001 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Schistosoma mansoni protein kinase C mu 0.0097 0.0182 0.0253
Echinococcus multilocularis dual specificity protein kinase clk2 0.0141 0.0329 0.0465
Schistosoma mansoni histone deacetylase hda2 0.0171 0.043 0.0604
Echinococcus granulosus cyclin dependent kinase 19 0.0151 0.0363 0.0514
Echinococcus multilocularis tyrosine protein kinase otk 0.0047 0.0009 0.0013
Echinococcus granulosus twitchin 0.0145 0.0343 0.0485
Loa Loa (eye worm) TK/INSR protein kinase 0.081 0.2599 0.3675
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0107 0.0213 0.0957
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0208 0.0556 0.0783
Loa Loa (eye worm) hypothetical protein 0.0075 0.0105 0.0144
Leishmania major protein kinase, putative 0.0065 0.0072 0.0278
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Brugia malayi Protein kinase domain containing protein 0.0053 0.003 0.0038
Schistosoma mansoni kinase 0.007 0.0087 0.0119
Echinococcus multilocularis mitogen activated protein kinase 11 0.0775 0.2481 0.3512
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0813 0.2611 0.3695
Plasmodium falciparum NIMA related kinase 1 0.0124 0.0271 0.1219
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.006 0.0053 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.001 0.0009
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0139 0.0323 0.0457
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0054 0.0072
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0031 0.0039
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0047 0.001 0.0014
Echinococcus multilocularis histone deacetylase 0.0171 0.043 0.0609
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.2991 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Brugia malayi Immunoglobulin I-set domain containing protein 0.0166 0.0414 0.0582
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Schistosoma mansoni protein kinase 0.0168 0.0422 0.0593
Onchocerca volvulus Tyrosine kinase homolog 0.0671 0.2129 0.7092
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0179 0.0459 0.0649
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.005 0.0021 0.0026
Onchocerca volvulus 0.0064 0.0069 0.0199
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0692 0.2198 1
Schistosoma mansoni septate junction protein 0.0047 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0072
Brugia malayi Protein kinase domain containing protein 0.081 0.2599 0.3675
Schistosoma mansoni septate junction protein 0.0047 0.0009 0.0009
Plasmodium falciparum protein serine/threonine kinase-1 0.0141 0.0329 0.1483
Echinococcus granulosus histone deacetylase 3 0.0221 0.0602 0.0852
Echinococcus granulosus histone deacetylase 8 0.0088 0.0151 0.0214
Echinococcus multilocularis death associated protein kinase 1 0.082 0.2634 0.3728
Schistosoma mansoni rap gtpase-activating protein 0.0074 0.0102 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0329 0.0461
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0098 0.0184 0.0256
Trypanosoma brucei histone deacetylase 3 0.0171 0.043 0.1722
Toxoplasma gondii histone deacetylase HDAC5 0.0088 0.0151 0.0673
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0168 0.0422 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0194 0.027
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0116 0.0246 0.0344
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Echinococcus granulosus aurora kinase A 0.0561 0.1754 0.2482
Echinococcus multilocularis mitogen activated protein kinase 14 0.0775 0.2481 0.3512
Brugia malayi Protein kinase domain containing protein 0.005 0.0021 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0108 0.0218 0.0309
Leishmania major protein kinase, putative 0.0141 0.0329 0.1314
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0101 0.0194 0.077
Loa Loa (eye worm) hypothetical protein 0.0082 0.013 0.018
Giardia lamblia Kinase, NEK 0.0124 0.0271 0.1112
Brugia malayi Immunoglobulin I-set domain containing protein 0.076 0.243 0.3437
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Schistosoma mansoni hypothetical protein 0.0074 0.0102 0.014
Giardia lamblia Kinase, CMGC CLK 0.0141 0.0329 0.138
Mycobacterium ulcerans hypothetical protein 0.0548 0.1712 0.0916
Entamoeba histolytica PH domain containing protein kinase, putative 0.0104 0.0205 0.0925
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.006 0.0053 0.0111
Echinococcus multilocularis epidermal growth factor receptor 0.2126 0.7066 1
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0139 0.0323 0.0453
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Echinococcus granulosus roundabout 2 0.0146 0.0345 0.0489
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.043 0.1722
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.005 0.0021 0.003
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0064 0.0069 0.0097
Echinococcus granulosus titin 0.0053 0.0031 0.0044
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0692 0.2198 0.8858
Loa Loa (eye worm) hypothetical protein 0.0142 0.0333 0.0468
Schistosoma mansoni titin 0.0047 0.0009 0.0009
Echinococcus granulosus dual specificity protein kinase clk2 0.0141 0.0329 0.0465
Loa Loa (eye worm) hypothetical protein 0.0142 0.0333 0.0468
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0062 0.006 0.0085
Brugia malayi Protein kinase domain containing protein 0.0141 0.0329 0.0461
Onchocerca volvulus 0.0078 0.0116 0.0357
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0168 0.0422 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0164 0.0228
Brugia malayi hypothetical protein 0.0064 0.0069 0.0093
Plasmodium vivax histone deacetylase, putative 0.0088 0.0151 0.056
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0083 0.0131 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0459 0.0645
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0072 0.0278
Echinococcus granulosus casein kinase I alpha 0.006 0.0054 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.003 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0067 0.0078 0.0106
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Trypanosoma brucei histone deacetylase 4 0.0171 0.043 0.1722
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0116 0.0246 0.0979
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.006 0.0053 0.0203
Trypanosoma brucei cdc2-related kinase 1 0.0107 0.0213 0.0847
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0097 0.0179 0.0254
Echinococcus granulosus lachesin 0.0047 0.0009 0.0013
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0053 0.0031 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0072 0.0317
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0208 0.0556 0.0787
Brugia malayi casein kinase 1, delta 0.006 0.0054 0.0072
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0108 0.0218 0.0309
Giardia lamblia Kinase, CMGC CDK 0.0107 0.0213 0.0847
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0168 0.0421 0.1685
Echinococcus granulosus Protein kinase C brain isozyme 0.0062 0.006 0.0085
Schistosoma mansoni protein kinase 0.0217 0.0588 0.0828
Echinococcus multilocularis dual specificity mitogen activated protein 0.0168 0.0421 0.0595
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Echinococcus granulosus Vam6:Vps39 protein 0.0074 0.0102 0.0145
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0104 0.0148
Brugia malayi Protein kinase domain containing protein 0.0187 0.0485 0.0682
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0314 0.0916 0.1297
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Brugia malayi protein C17H12.11 0.006 0.0054 0.0072
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.006 0.0053 0.0229
Echinococcus granulosus defective proboscis extension response 0.0095 0.0175 0.0248
Trypanosoma cruzi casein kinase, delta isoform, putative 0.006 0.0054 0.0205
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0108 0.0218 0.0309
Echinococcus multilocularis neuroglian 0.0122 0.0266 0.0376
Loa Loa (eye worm) hypothetical protein 0.0078 0.0116 0.016
Schistosoma mansoni kinase 0.0067 0.0078 0.0106
Loa Loa (eye worm) hypothetical protein 0.0136 0.0312 0.0437
Echinococcus granulosus protein kinase c epsilon type 0.0062 0.006 0.0085
Echinococcus multilocularis casein kinase I alpha 0.006 0.0054 0.0076
Toxoplasma gondii AGC kinase 0.0047 0.001 0.003
Entamoeba histolytica protein kinase, putative 0.0561 0.1754 0.7975
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0093 0.0166 0.0235
Schistosoma mansoni protein kinase 0.0314 0.0916 0.1293
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0246 0.1106
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0009 0.0009
Echinococcus multilocularis histone deacetylase 1 0.0221 0.0602 0.0852
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0139 0.0324 0.0458
Echinococcus granulosus tyrosine protein kinase Blk 0.0093 0.0166 0.0235
Schistosoma mansoni tyrosine kinase 0.1141 0.3722 0.5266
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Schistosoma mansoni tyrosine kinase 0.0108 0.0218 0.0305
Echinococcus granulosus TGF-beta receptor type-1 0.0093 0.0166 0.0236
Onchocerca volvulus 0.0064 0.0069 0.0199
Echinococcus granulosus mitogen activated protein kinase 11 0.0775 0.2481 0.3512
Brugia malayi hypothetical protein 0.0074 0.0102 0.014
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0136 0.0312 0.0437
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0018 0.0074
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0047 0.001 0.0009
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0179 0.0459 0.1503
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.0459 0.0645
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0105 0.0207 0.0289
Entamoeba histolytica casein kinase, putative 0.006 0.0054 0.0235
Brugia malayi C1-like domain containing protein 0.0097 0.0182 0.0253
Echinococcus granulosus histone deacetylase 6 0.0171 0.043 0.0609
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0083 0.0131 0.0182
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Loa Loa (eye worm) hypothetical protein 0.0074 0.0102 0.014
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0052 0.0028 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0053 0.0071
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0314 0.0916 0.1297
Echinococcus multilocularis twitchin 0.0049 0.0019 0.0027
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.0242 0.0343
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0141 0.0329 0.1314
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0095 0.0175 0.0248
Plasmodium falciparum casein kinase 1 0.006 0.0054 0.0231
Echinococcus granulosus histone deacetylase 6 0.0171 0.043 0.0609
Loa Loa (eye worm) TK/ABL protein kinase 0.0468 0.1438 0.2032
Loa Loa (eye worm) hypothetical protein 0.006 0.0053 0.0071
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0064 0.0069 0.0303
Echinococcus granulosus tyrosine protein kinase Btk29A 0.021 0.0564 0.0798
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Brugia malayi Protein kinase domain containing protein 0.0314 0.0916 0.1293
Loa Loa (eye worm) hypothetical protein 0.005 0.0021 0.0026
Brugia malayi Protein kinase domain containing protein 0.0113 0.0233 0.0325
Loa Loa (eye worm) TKL/LRRK protein kinase 0.008 0.0123 0.017
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0113 0.0233 0.0325
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0108 0.0218 0.0309
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0101 0.0194 0.077
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0139 0.0323 0.0453
Echinococcus multilocularis Immunoglobulin 0.0095 0.0175 0.0248
Trypanosoma cruzi histone deacetylase 1, putative 0.0221 0.0602 0.2416
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0074 0.0102 0.04
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.003 0.0121
Echinococcus multilocularis tyrosine protein kinase Abl 0.0234 0.0645 0.0912
Schistosoma mansoni vesicular amine transporter 0.0095 0.0175 0.0243
Trichomonas vaginalis STE family protein kinase 0.0168 0.0421 0.1902
Loa Loa (eye worm) hypothetical protein 0.0099 0.0187 0.026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.043 0.1722
Brugia malayi cyclin-dependent kinase 7 homolog 0.0106 0.021 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.001 0.0009
Loa Loa (eye worm) histone deacetylase 7A 0.0171 0.043 0.0604
Echinococcus multilocularis histone deacetylase 6 0.0171 0.043 0.0609
Brugia malayi serine/threonine protein kinase 6 0.0561 0.1754 0.2479
Echinococcus granulosus cyclin dependent kinase 5 0.0107 0.0213 0.0302
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.0239 0.108
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.021 0.0564 0.0798
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0243
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0323 0.0453
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0101 0.0194 0.077
Loa Loa (eye worm) histone deacetylase 1 0.0221 0.0602 0.0848
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.0243 0.0344
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0108 0.0218 0.0309
Echinococcus granulosus tyrosine protein kinase Src64B 0.0108 0.0218 0.0309
Loa Loa (eye worm) hypothetical protein 0.0082 0.013 0.018
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0151 0.0363 0.051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0021 0.0026
Entamoeba histolytica protein kinase, putative 0.0047 0.001 0.0033
Trypanosoma brucei polo-like protein kinase 0.0115 0.0242 0.0966
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.006 0.0081
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0116 0.0246 0.0344
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.005 0.0021 0.0026
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0047 0.001 0.0014
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.008 0.0123 0.0174
Schistosoma mansoni neuroglian 0.005 0.0021 0.0026
Loa Loa (eye worm) gastrulation defective protein 1 0.0128 0.0286 0.0401
Entamoeba histolytica protein kinase, putative 0.0116 0.0246 0.1109
Onchocerca volvulus 0.0136 0.0312 0.1011
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0197 0.0521 0.2089
Trichomonas vaginalis STE family protein kinase 0.0168 0.0421 0.1902
Plasmodium falciparum calcium-dependent protein kinase 2 0.006 0.0053 0.0229
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0692 0.2198 0.3108
Schistosoma mansoni ephrin receptor 0.0046 0.0007 0.0005
Entamoeba histolytica histone deacetylase, putative 0.0221 0.0602 0.273
Leishmania major protein kinase, putative 0.006 0.0053 0.0203
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0485 0.0682
Onchocerca volvulus 0.0064 0.0069 0.0199
Schistosoma mansoni tyrosine kinase 0.1141 0.3722 0.5266
Brugia malayi SH2 domain containing protein 0.0064 0.0069 0.0093
Schistosoma mansoni cell adhesion molecule 0.005 0.0021 0.0026
Brugia malayi hypothetical protein 0.006 0.0054 0.0072
Loa Loa (eye worm) histone deacetylase 3 0.0221 0.0602 0.0848
Trypanosoma brucei histone deacetylase 1 0.0221 0.0602 0.2416
Trypanosoma cruzi histone deacetylase, putative 0.0088 0.0151 0.0596
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0101 0.0194 0.027
Echinococcus multilocularis transfer RNA-Thr 0.0205 0.0546 0.0772
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.2154 0.3045
Trypanosoma brucei rac serine-threonine kinase, putative 0.005 0.0021 0.0072
Mycobacterium tuberculosis Conserved hypothetical protein 0.0548 0.1712 0.0916
Echinococcus granulosus tyrosine protein kinase Src42A 0.0052 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0221 0.0602 0.0848
Brugia malayi Protein kinase domain containing protein 0.0912 0.2945 0.4165
Plasmodium falciparum calcium-dependent protein kinase 3 0.006 0.0053 0.0229
Echinococcus granulosus TGF beta receptor type 1 0.0093 0.0166 0.0236
Trypanosoma brucei aurora B kinase 0.0561 0.1754 0.7064
Echinococcus multilocularis aurora kinase A 0.0561 0.1754 0.2482
Schistosoma mansoni protein kinase 0.0082 0.0128 0.0176
Giardia lamblia Kinase, CK1 Casein kinase 0.006 0.0054 0.0113
Giardia lamblia Kinase, AGC AKT 0.0105 0.0207 0.0821
Brugia malayi Cam kinase protein 1 0.006 0.0053 0.0071
Leishmania major protein kinase A catalytic subunit isoform 1 0.0101 0.0194 0.077
Brugia malayi intracellular kinase 0.0116 0.0246 0.0344
Trypanosoma brucei protein kinase, putative 0.0116 0.0246 0.0979
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0073 0.0099 0.0135
Brugia malayi Fibronectin type III domain containing protein 0.0099 0.0187 0.026
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Treponema pallidum licC protein (licC) 0.0548 0.1712 0.5
Schistosoma mansoni protein kinase 0.006 0.0054 0.0072
Echinococcus multilocularis rho associated protein kinase 0.0308 0.0898 0.1271
Loa Loa (eye worm) hypothetical protein 0.0136 0.0312 0.0437
Echinococcus granulosus tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0072 0.0278
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0148 0.0355 0.0498
Onchocerca volvulus 0.0064 0.0069 0.0199
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0107 0.0213 0.0297
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Echinococcus granulosus histone deacetylase 7 0.0171 0.043 0.0609
Echinococcus multilocularis protein kinase c iota type 0.0062 0.006 0.0085
Trypanosoma brucei histone deacetylase 2 0.0088 0.0151 0.0596
Brugia malayi probable protein kinase 0.0156 0.0379 0.0532
Echinococcus multilocularis casein kinase i 0.006 0.0054 0.0076
Echinococcus multilocularis 0.0082 0.0128 0.0181
Plasmodium vivax calcium-dependent protein kinase, putative 0.006 0.0053 0.0111
Loa Loa (eye worm) hypothetical protein 0.0095 0.0175 0.0243
Echinococcus granulosus rho-associated protein kinase 1 0.0308 0.0898 0.1271
Echinococcus multilocularis protein kinase c epsilon type 0.0062 0.006 0.0085
Onchocerca volvulus 0.0053 0.0031 0.0072
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0097 0.0179 0.0254
Loa Loa (eye worm) TK/KIN16 protein kinase 0.076 0.243 0.3437
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0009 0.0009
Schistosoma mansoni protein kinase 0.0168 0.0421 0.0591
Echinococcus granulosus cyclin dependent kinase 0.0107 0.0213 0.0302
Brugia malayi casein kinase I 0.006 0.0054 0.0072
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.2991 1 1
Brugia malayi Protein kinase domain containing protein 0.0107 0.0213 0.0297
Loa Loa (eye worm) AUR protein kinase 0.0561 0.1754 0.2479
Brugia malayi protein kinase C II. 0.0062 0.006 0.0081
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0141 0.0329 0.1483
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.0459 0.0645
Echinococcus multilocularis peroxidasin 0.0047 0.0011 0.0015
Brugia malayi Temporarily assigned gene name protein 59 0.0074 0.0102 0.014
Trichomonas vaginalis AGC family protein kinase 0.005 0.0021 0.0082
Echinococcus multilocularis neuroglian 0.005 0.0021 0.003
Loa Loa (eye worm) IKK protein kinase 0.0928 0.2999 0.4242
Onchocerca volvulus 0.0928 0.2999 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0101 0.0194 0.077
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0665 0.0937
Brugia malayi serine/threonine kinase 12 0.0561 0.1754 0.2479
Entamoeba histolytica protein kinase, putative 0.0197 0.0521 0.2361
Echinococcus granulosus casein kinase I delta 0.006 0.0054 0.0076
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0054 0.0231
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0116 0.0246 0.0979
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0246 0.1109
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0074 0.0102 0.014
Loa Loa (eye worm) hypothetical protein 0.0062 0.0063 0.0085
Schistosoma mansoni cell adhesion molecule 0.0119 0.0255 0.0356
Echinococcus granulosus cyclin dependent kinase 7 0.0098 0.0184 0.026
Echinococcus multilocularis cyclin dependent kinase 19 0.0151 0.0363 0.0514
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 0.3108
Leishmania major histone deacetylase, putative 0.0221 0.0602 0.2416
Loa Loa (eye worm) hypothetical protein 0.0064 0.0069 0.0093
Brugia malayi Protein kinase domain containing protein 0.0047 0.001 0.0009
Loa Loa (eye worm) histone deacetylase 0.0171 0.043 0.0604
Echinococcus granulosus activated cdc42 kinase 1 0.0205 0.0546 0.0772
Brugia malayi histone deacetylase 1 (HD1) 0.0221 0.0602 0.0848
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0246 0.1109
Echinococcus multilocularis serine:threonine protein kinase 0.0062 0.0063 0.0089
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0101 0.0194 0.0759
Schistosoma mansoni protein kinase 0.0561 0.1754 0.2479
Loa Loa (eye worm) hypothetical protein 0.0074 0.0102 0.014
Echinococcus granulosus serine:threonine protein kinase N2 0.0047 0.001 0.0014
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0692 0.2198 0.8858
Echinococcus granulosus activated cdc42 kinase 1 0.0205 0.0546 0.0772
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0213 0.0957
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0136 0.0312 0.0442
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0363 0.051
Loa Loa (eye worm) TK protein kinase 0.0093 0.0166 0.0231
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.0242 0.0966
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0141 0.0329 0.1314
Loa Loa (eye worm) hypothetical protein 0.0133 0.0302 0.0423
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0692 0.2198 0.3111
Schistosoma mansoni protein kinase 0.0168 0.0422 0.0593
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0548 0.1712 0.7784
Onchocerca volvulus 0.0286 0.0821 0.2714
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0692 0.2198 1
Leishmania major casein kinase, putative 0.006 0.0054 0.0205
Echinococcus multilocularis mitogen activated protein kinase 14 0.0775 0.2481 0.3512
Schistosoma mansoni nephrin 0.005 0.0021 0.0026
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0101 0.0194 0.077
Schistosoma mansoni protein kinase 0.0113 0.0233 0.0325
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0141 0.0329 0.1314
Leishmania major histone deacetylase, putative 0.0221 0.0602 0.2416
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0133 0.0302 0.0427
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0095 0.0175 0.0243
Echinococcus multilocularis insulin receptor 0.081 0.2599 0.3678
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.006 0.0053 0.0111
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.006 0.0053 0.0071
Brugia malayi Histone deacetylase family protein 0.0171 0.043 0.0604
Schistosoma mansoni tyrosine kinase 0.0058 0.0047 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0053 0.0229
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.006 0.0053 0.0229
Echinococcus multilocularis histone deacetylase 8 0.0088 0.0151 0.0214
Plasmodium falciparum calcium-dependent protein kinase 1 0.006 0.0053 0.0229
Loa Loa (eye worm) hypothetical protein 0.0105 0.0207 0.0288
Echinococcus multilocularis casein kinase I delta 0.006 0.0054 0.0076
Loa Loa (eye worm) hypothetical protein 0.0101 0.0194 0.027
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0561 0.1754 0.2482
Onchocerca volvulus 0.0064 0.0069 0.0199
Schistosoma mansoni tyrosine kinase 0.1183 0.3866 0.547
Echinococcus granulosus casein kinase I alpha 0.006 0.0054 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Schistosoma mansoni tyrosine kinase 0.008 0.0121 0.0167
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0775 0.2481 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0293 0.0845 0.1191
Brugia malayi protein unc-22 0.0053 0.0031 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0194 0.0869
Echinococcus multilocularis histone deacetylase 3 0.0221 0.0602 0.0852
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0194 0.027
Trypanosoma cruzi aurora B kinase, putative 0.0561 0.1754 0.7064
Loa Loa (eye worm) hypothetical protein 0.0115 0.0243 0.0339
Echinococcus granulosus cyclin dependent kinase 1 0.0107 0.0213 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0521 0.0733
Trypanosoma brucei casein kinase I, isoform 2 0.006 0.0054 0.0205
Loa Loa (eye worm) hypothetical protein 0.0197 0.0518 0.073
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.006 0.0054 0.0072
Brugia malayi protein-tyrosine kinase 0.0093 0.0166 0.0231
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.0242 0.0343
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0217 0.0588 0.0832
Entamoeba histolytica cell division protein kinase 2, putative 0.0107 0.0213 0.096
Echinococcus granulosus dual specificity mitogen activated protein 0.0168 0.0421 0.0595
Schistosoma mansoni tyrosine kinase 0.0446 0.1364 0.1927
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0078 0.0117 0.0165
Echinococcus multilocularis serine:threonine protein kinase 0.0062 0.0063 0.0089
Brugia malayi Histone deacetylase family protein 0.0171 0.043 0.0604
Schistosoma mansoni nephrin 0.0126 0.0278 0.0389
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0692 0.2198 0.3108
Onchocerca volvulus 0.0075 0.0105 0.0318
Plasmodium falciparum serine/threonine protein kinase, putative 0.0561 0.1754 0.7974
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0314 0.0916 0.1293
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0069 0.0085 0.0121
Echinococcus multilocularis activated cdc42 kinase 1 0.0205 0.0546 0.0772
Trichomonas vaginalis CAMK family protein kinase 0.0123 0.0269 0.121
Echinococcus granulosus c-Jun N-terminal kinases 0.0249 0.0696 0.0985
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0179 0.0459 0.0645
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.0242 0.1094
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0561 0.1754 0.7975
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0449 0.1376 0.1948
Loa Loa (eye worm) hypothetical protein 0.0074 0.0102 0.014
Echinococcus granulosus histone deacetylase 1 0.0221 0.0602 0.0852
Entamoeba histolytica serine/threonine protein kinase, putative 0.0045 0.0003 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0164 0.0228
Toxoplasma gondii casein kinase I 0.006 0.0054 0.0231
Echinococcus multilocularis Immunoglobulin 0.0095 0.0175 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Brugia malayi Protein kinase domain containing protein 0.0083 0.0131 0.0182
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0136 0.0312 0.0437
Echinococcus multilocularis cyclin dependent kinase 0.0107 0.0213 0.0302
Loa Loa (eye worm) hypothetical protein 0.0096 0.0176 0.0245
Onchocerca volvulus 0.0064 0.0069 0.0199
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Schistosoma mansoni vam6/vps39 related 0.0074 0.0102 0.014
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0246 0.1106
Echinococcus granulosus casein kinase I alpha 0.006 0.0054 0.0076
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0561 0.1754 0.2482
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.006 0.0053 0.0076
Brugia malayi Protein kinase domain containing protein 0.0064 0.0069 0.0093
Schistosoma mansoni titin 0.0053 0.0031 0.0039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0548 0.1712 0.0916
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0139 0.0323 0.0457
Echinococcus multilocularis titin 0.0053 0.0031 0.0044
Echinococcus granulosus activin receptor type 0.0424 0.1289 0.1824
Entamoeba histolytica protein kinase, putative 0.005 0.0021 0.0085
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0101 0.0194 0.077
Echinococcus multilocularis histone deacetylase 6 0.0171 0.043 0.0609
Echinococcus granulosus c src tyrosine kinase 0.008 0.0121 0.0171
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0692 0.2198 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.0242 0.0339
Plasmodium vivax histone deacetylase 1, putative 0.0221 0.0602 0.2639
Echinococcus granulosus insulin receptor 0.081 0.2599 0.3678
Leishmania major protein kinase, putative 0.0561 0.1754 0.7064
Echinococcus multilocularis casein kinase I alpha 0.006 0.0054 0.0076
Echinococcus granulosus microtubule associated protein 2 0.0679 0.2154 0.3048
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0213 0.0297
Echinococcus multilocularis roundabout 2 0.0146 0.0345 0.0489
Echinococcus granulosus cyclin dependent kinase 9 0.0067 0.0078 0.011
Echinococcus granulosus tyrosine protein kinase ABL1 0.0468 0.1438 0.2036
Plasmodium falciparum calcium-dependent protein kinase 5 0.006 0.0053 0.0229
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0036 0.0149
Loa Loa (eye worm) hypothetical protein 0.0175 0.0444 0.0624
Schistosoma mansoni serine/threonine protein kinase 0.0308 0.0898 0.1267
Trichomonas vaginalis AGC family protein kinase 0.0124 0.0271 0.1219
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0054 0.0072
Giardia lamblia Kinase, CMGC GSK 0.0116 0.0246 0.0998
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0045 0.0003 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0092 0.0164 0.0233
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Echinococcus multilocularis protein KINase family member (kin 25) 0.0105 0.0207 0.0293
Loa Loa (eye worm) hypothetical protein 0.0047 0.0011 0.0011
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0116 0.0246 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.0696 0.0981
Leishmania major histone deacetylase, putative 0.0171 0.043 0.1722
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Echinococcus granulosus raf serine:threonine protein kinase 0.0057 0.0045 0.0064
Plasmodium vivax histone deacetylase 2, putative 0.0171 0.043 0.1847
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0221 0.0602 0.2727
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0107 0.0213 0.0847
Brugia malayi Furin-like cysteine rich region family protein 0.2126 0.7066 1
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0242 0.0339
Echinococcus multilocularis cyclin dependent kinase 1 0.0107 0.0213 0.0302
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0101 0.0194 0.0869
Plasmodium falciparum protein kinase, putative 0.0065 0.0072 0.0313
Schistosoma mansoni tyrosine kinase 0.0108 0.0218 0.0305
Echinococcus multilocularis contactin neuroglian septate junction protein 0.005 0.0021 0.003
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0141 0.0329 0.0461
Echinococcus granulosus protein kinase 0.0082 0.0128 0.0181
Leishmania major histone deacetylase, putative 0.0171 0.043 0.1722
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0561 0.1754 0.7975
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0184 0.0256
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0561 0.1754 0.795
Echinococcus granulosus tyrosine protein kinase Src42A 0.0108 0.0218 0.0309
Schistosoma mansoni histone deacetylase hda2 0.0088 0.0151 0.0209
Brugia malayi bone morphogenetic protein type 1 receptor 0.0113 0.0233 0.0325
Loa Loa (eye worm) TK/ALK protein kinase 0.0545 0.1701 0.2404
Trypanosoma cruzi cdc2-related kinase 1 0.0107 0.0213 0.0847
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0021 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0141 0.0329 0.1483
Brugia malayi serine/threonine-protein kinase PAK 7 0.0202 0.0537 0.0756
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0009 0.0009
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Loa Loa (eye worm) AGC/PKA protein kinase 0.0101 0.0194 0.027
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0078 0.0345
Echinococcus granulosus protein kinase c iota type 0.0062 0.006 0.0085
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0108 0.0218 0.0309
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.005 0.0021 0.003
Schistosoma mansoni histone deacetylase 4 5 0.0171 0.043 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0556 0.0783
Schistosoma mansoni cell adhesion molecule 0.0047 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0031 0.0039
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0074 0.0102 0.04
Echinococcus multilocularis raf serine:threonine protein kinase 0.0057 0.0045 0.0064
Echinococcus multilocularis casein kinase I alpha 0.006 0.0054 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0021 0.0026
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0912 0.2945 0.4165
Echinococcus granulosus calcium activated potassium channel 0.0053 0.003 0.0042
Echinococcus multilocularis cyclin dependent kinase 9 0.0067 0.0078 0.011
Echinococcus multilocularis protein kinase shaggy 0.0116 0.0246 0.0348
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0101 0.0194 0.0869
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.043 0.1722
Giardia lamblia Kinase, CMGC CDK 0.0107 0.0213 0.0847
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0104 0.0148
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Mycobacterium ulcerans hypothetical protein 0.0548 0.1712 0.0916
Trypanosoma brucei cdc2-related kinase 3 0.0107 0.0213 0.0847
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0692 0.2198 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0151 0.0209
Giardia lamblia Kinase, NEK 0.0124 0.0271 0.1112
Echinococcus granulosus mitogen activated protein kinase 14 0.0775 0.2481 0.3512
Echinococcus multilocularis 0.0118 0.0251 0.0356
Loa Loa (eye worm) hypothetical protein 0.0099 0.0187 0.026
Echinococcus granulosus epidermal growth factor receptor 0.1183 0.3866 0.5472
Schistosoma mansoni protein kinase 0.0156 0.0379 0.0532
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0097 0.0182 0.0253
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0112 0.023 0.0325
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0112 0.023 0.0325
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0053 0.0076
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0168 0.0421 0.1685
Giardia lamblia Kinase, CMGC GSK 0.0116 0.0246 0.0998
Schistosoma mansoni tyrosine kinase 0.081 0.2599 0.3675
Trichomonas vaginalis STE family protein kinase 0.0124 0.0271 0.1219
Brugia malayi p70 ribosomal S6 kinase beta 0.0047 0.001 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.023 0.0321
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0197 0.0521 0.0733
Echinococcus multilocularis epidermal growth factor receptor 0.1183 0.3866 0.5472
Schistosoma mansoni tyrosine kinase 0.0105 0.0207 0.0288
Echinococcus granulosus hypothetical protein 0.0118 0.0251 0.0356
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0197 0.0521 0.2089
Loa Loa (eye worm) TK/EGFR protein kinase 0.2126 0.7066 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0097 0.0182 0.0253
Leishmania major protein kinase A catalytic subunit 0.0101 0.0194 0.077
Echinococcus multilocularis tyrosine protein kinase Blk 0.0093 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0162 0.0402 0.0565
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0217 0.0588 0.0832
Brugia malayi SH2 domain containing protein 0.0064 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Schistosoma mansoni histone deacetylase 4 5 0.0171 0.043 0.0604
Schistosoma mansoni tyrosine kinase 0.029 0.0835 0.1177
Brugia malayi Prion-like- 0.0047 0.0009 0.0009
Echinococcus granulosus tyrosine kinase 0.0093 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0151 0.0362 0.0508
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0242 0.0966
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0168 0.0421 0.1685
Brugia malayi Protein kinase domain containing protein 0.0179 0.0459 0.0645
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.001 0.0009
Echinococcus granulosus tyrosine protein kinase HCK 0.0071 0.0092 0.013
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0072
Toxoplasma gondii histone deacetylase HDAC1 0.0171 0.043 0.1945
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.001 0.0014
Echinococcus multilocularis cyclin dependent kinase 1 0.0107 0.0213 0.0302
Giardia lamblia Kinase, STE STE20 0.0168 0.0421 0.1804
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.2991 1 0.5
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0054 0.0231
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0095 0.0175 0.0243
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Leishmania major protein kinase, putative 0.0141 0.0329 0.1314
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0129 0.0289 0.0409
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0109 0.0219 0.0306
Echinococcus granulosus serine:threonine protein kinase 0.0062 0.0063 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0099 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0078 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.006 0.0081
Echinococcus multilocularis cyclin dependent kinase 5 0.0107 0.0213 0.0302
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0093 0.0166 0.0235
Echinococcus granulosus tyrosine protein kinase shark 0.0064 0.0069 0.0097
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0202 0.0537 0.0756
Trypanosoma cruzi histone deacetylase, putative 0.0088 0.0151 0.0596
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0187 0.0485 0.0686
Loa Loa (eye worm) hypothetical protein 0.0205 0.0546 0.0768
Schistosoma mansoni protein kinase 0.0168 0.0422 0.0593
Entamoeba histolytica protein kinase domain containing protein 0.0561 0.1754 0.7975
Echinococcus granulosus roundabout 2 0.005 0.0021 0.003
Schistosoma mansoni histone deacetylase 1 2 3 0.0088 0.0151 0.0209
Schistosoma mansoni cell adhesion molecule 0.005 0.0021 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.006 0.0081
Brugia malayi Tyrosine-protein kinase abl-1 0.0234 0.0645 0.0908
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0208 0.0556 0.0787
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0355 0.0498
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.001 0.0014
Plasmodium falciparum histone deacetylase, putative 0.0171 0.043 0.1945
Entamoeba histolytica protein kinase, putative 0.006 0.0053 0.0233
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0037 0.0048
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0078 0.0117 0.0165
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0197 0.0521 0.2089
Brugia malayi cell division control protein 2 homolog 0.0107 0.0213 0.0297
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0055 0.0037 0.0048
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.008 0.0123 0.0174
Onchocerca volvulus 0.0116 0.0246 0.0791
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0116 0.0246 0.0348
Loa Loa (eye worm) hypothetical protein 0.0118 0.0251 0.0352
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0047 0.001 0.0014
Loa Loa (eye worm) TK/ROR protein kinase 0.0069 0.0085 0.0116
Loa Loa (eye worm) hypothetical protein 0.0047 0.0009 0.0009
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0047 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0108 0.0218 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.003 0.0038
Loa Loa (eye worm) AUR protein kinase 0.0561 0.1754 0.2479
Plasmodium vivax protein kinase Crk2 0.0107 0.0213 0.0847
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0062 0.0063 0.0085
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.0242 0.078
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0221 0.0602 0.2727
Trichomonas vaginalis AGC family protein kinase 0.0047 0.001 0.003
Brugia malayi hypothetical protein 0.0208 0.0556 0.0783
Schistosoma mansoni serine/threonine kinase 0.0047 0.001 0.0009
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0168 0.0421 0.0591
Echinococcus granulosus serine:threonine protein kinase 0.0062 0.0063 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Toxoplasma gondii aurora kinase 0.0561 0.1754 0.7974
Loa Loa (eye worm) AGC/PKA protein kinase 0.0101 0.0194 0.027
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0141 0.0329 0.1314
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0072
Trypanosoma cruzi cdc2-related kinase 3 0.0107 0.0213 0.0847
Echinococcus granulosus protein tyrosine kinase 0.029 0.0835 0.1181
Loa Loa (eye worm) hypothetical protein 0.0475 0.1463 0.2067
Echinococcus granulosus casein kinase I delta 0.006 0.0054 0.0076
Brugia malayi Protein kinase domain containing protein 0.0151 0.0363 0.051
Loa Loa (eye worm) hypothetical protein 0.007 0.0089 0.0122
Echinococcus granulosus fibroblast growth factor receptor 4 0.0139 0.0324 0.0458
Brugia malayi Protein kinase domain containing protein 0.0062 0.0063 0.0085
Loa Loa (eye worm) AGC/AKT protein kinase 0.005 0.0021 0.0025
Echinococcus multilocularis tyrosine protein kinase Srms 0.0093 0.0166 0.0235
Plasmodium vivax casein kinase 1, putative 0.006 0.0054 0.0113
Echinococcus multilocularis hemicentin 1 0.0047 0.0009 0.0013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Loa Loa (eye worm) hypothetical protein 0.0084 0.0136 0.0188
Echinococcus multilocularis serine threonine protein kinase 0.0047 0.001 0.0014
Giardia lamblia Aurora kinase 0.0561 0.1754 0.795
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0047 0.001 0.0009
Echinococcus granulosus neuroglian 0.0122 0.0266 0.0376
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0775 0.2481 1
Trypanosoma cruzi casein kinase, putative 0.006 0.0054 0.0205
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0107 0.0213 0.0302
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0019 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.003 0.0038
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1183 0.3866 0.5472
Toxoplasma gondii histone deacetylase HDAC4 0.0088 0.0151 0.0673
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0116 0.0246 0.1106
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0101 0.0194 0.0275
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0187 0.0485 0.0682
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0063 0.0272
Trichomonas vaginalis histone deacetylase, putative 0.0221 0.0602 0.2727
Onchocerca volvulus 0.0308 0.0898 0.2972
Echinococcus multilocularis cyclin dependent kinase 7 0.0098 0.0184 0.026
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0692 0.2198 0.8858
Brugia malayi Immunoglobulin I-set domain containing protein 0.0099 0.0187 0.026
Entamoeba histolytica PH domain containing protein kinase, putative 0.0104 0.0205 0.0925
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0082 0.0128 0.0176
Schistosoma mansoni tyrosine kinase 0.081 0.2599 0.3675
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0179 0.0459 0.0649
Echinococcus granulosus protein kinase C gamma type 0.0047 0.001 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0213 0.0957
Loa Loa (eye worm) TK protein kinase 0.0071 0.0092 0.0126
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0062 0.006 0.0081
Echinococcus multilocularis roundabout 2 0.005 0.0021 0.003
Toxoplasma gondii histone deacetylase HDAC2 0.0221 0.0602 0.2727
Echinococcus granulosus epidermal growth factor receptor 0.2126 0.7066 1
Echinococcus granulosus histone deacetylase 6 0.0171 0.043 0.0609
Trichomonas vaginalis AGC family protein kinase 0.0561 0.1754 0.7974
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0168 0.0421 0.0591
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0197 0.0521 0.2089
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0184 0.0256
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0074 0.0102 0.0145
Echinococcus granulosus NDR protein kinase 0.0047 0.001 0.0014
Echinococcus granulosus tyrosine kinase 0.0064 0.0069 0.0097
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0108 0.0218 0.0309
Entamoeba histolytica casein kinase 1, putative 0.006 0.0054 0.0235
Trichomonas vaginalis STE family protein kinase 0.0168 0.0421 0.1902
Plasmodium falciparum histone deacetylase 2 0.0171 0.043 0.1945
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0775 0.2481 1
Onchocerca volvulus 0.006 0.0054 0.015
Plasmodium vivax histone deacetylase, putative 0.0171 0.043 0.1847
Echinococcus multilocularis tyrosine kinase 0.0064 0.0069 0.0097
Schistosoma mansoni histone deacetylase 0.0221 0.0602 0.0848
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.008 0.0121 0.0167
Brugia malayi Histone deacetylase 1 0.0221 0.0602 0.0848
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0069 0.0085 0.0121
Echinococcus multilocularis tyrosine protein kinase HCK 0.0071 0.0092 0.013
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.2154 0.3048
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0108 0.0219 0.087
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0692 0.2198 1
Schistosoma mansoni histone deacetylase 0.0221 0.0602 0.0848
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0242 0.109
Brugia malayi P38 map kinase family protein 2 0.0775 0.2481 0.3509
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0074 0.0102 0.0145
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0249 0.0696 0.0985
Echinococcus multilocularis casein kinase I delta 0.006 0.0054 0.0076
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0065 0.0072 0.0313
Loa Loa (eye worm) TK/FER protein kinase 0.0064 0.0069 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0194 0.027
Brugia malayi Protein kinase domain containing protein 0.0545 0.1701 0.2405
Echinococcus granulosus peroxidasin 0.0047 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0182 0.047 0.0661
Schistosoma mansoni tyrosine kinase 0.1183 0.3866 0.547
Schistosoma mansoni tyrosine kinase 0.0064 0.0069 0.0093
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0213 0.0957
Echinococcus granulosus casein kinase i 0.006 0.0054 0.0076
Echinococcus multilocularis tyrosine protein kinase shark 0.0064 0.0069 0.0097
Echinococcus multilocularis hemicentin 1 0.0047 0.0009 0.0013
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0105 0.0207 0.0293
Echinococcus multilocularis TGF beta receptor type 1 0.0093 0.0166 0.0236

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 12 ml/min.kg Hepatic clearance in human hepatocytes after 1 to 4 hrs by LC/MS/MS analysis ChEMBL. 23659214
EC50 (binding) = 84 nM Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins ChEMBL. 23659214
EC50 (binding) = 1600 nM Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins in presence of whole blood ChEMBL. 23659214
EC50 (binding) = 2900 nM Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins ChEMBL. 23659214
Ki (binding) = 1.8 nM Inhibition of recombinant JAK1 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins in presence of ATP ChEMBL. 23659214
Ki (binding) = 44 nM Inhibition of recombinant JAK2 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins in presence of ATP ChEMBL. 23659214
Ratio EC50 (binding) = 19 Ratio of EC50 for JAK1 in human TF1 cells in presence of whole blood to EC50 for JAK1 in human TF1 cells in absence of whole blood ChEMBL. 23659214

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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