TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 575.725 | Formula: C30H37N7O3S
H donors: 2 H acceptors: 4 LogP: 3.47 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(ccc1NS(=O)(=O)c1ccccc1)c1cn(c2c1c(N)ncn2)[C@@H]1CC[C@H](CC1)N1CCN(CC1)C
InChi: 1S/C30H37N7O3S/c1-35-14-16-36(17-15-35)22-9-11-23(12-10-22)37-19-25(28-29(31)32-20-33-30(28)37)21-8-13-26(27(18-21)40-2)34-41(38,39)24-6-4-3-5-7-24/h3-8,13,18-20,22-23,34H,9-12,14-17H2,1-2H3,(H2,31,32,33)/t22-,23-
InChiKey: PBHLCYDKXKGQAQ-YHBQERECSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TEK tyrosine kinase, endothelial	Starlite/ChEMBL	References
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0251	0.1742	0.1741
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0028	0.0103	0.0101
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0034	0.0147	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Loa Loa (eye worm)	PH domain-containing protein	0.0028	0.0103	0.0101
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0034	0.0147	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Echinococcus granulosus	Oxysterol binding protein 11	0.0028	0.0103	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.1742	1
Echinococcus granulosus	oxysterol binding protein 3	0.0028	0.0103	0.0101
Schistosoma mansoni	axis inhibition protein axin	0.0251	0.1742	0.1742
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0018	0.0031	0.003
Brugia malayi	protein-tyrosine kinase	0.0049	0.026	0.0264
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0034	0.0147	1
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0037	0.0168	0.0166
Echinococcus granulosus	calcium dependent secretion activator 1	0.0028	0.0103	0.0101
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1742	0.1741
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0058	0.0326	0.0324
Echinococcus granulosus	expressed protein	0.0251	0.1742	0.1741
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1349	0.9815	0.9815
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0028	0.0103	0.0581
Onchocerca volvulus		0.0028	0.0103	0.0857
Entamoeba histolytica	protein kinase, putative	0.0034	0.0147	0.0835
Schistosoma mansoni	serine/threonine protein kinase	0.1374	1	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0103	0.0581
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0028	0.0103	0.0581
Echinococcus multilocularis	rac serine:threonine kinase	0.0034	0.0147	0.0145
Entamoeba histolytica	protein kinase, putative	0.0034	0.0147	0.0835
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0326	0.0324
Trypanosoma cruzi	NIMA-related kinase, putative	0.0034	0.0147	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1742	0.1741
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0034	0.0147	1
Schistosoma mansoni	axis inhibition protein axin	0.0251	0.1742	0.1742
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0028	0.0103	0.0101
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0028	0.0103	0.0101
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0058	0.0326	0.0324
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0028	0.0103	0.0581
Entamoeba histolytica	hypothetical protein	0.0251	0.1742	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0028	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0028	0.0103	0.0103
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0147	0.0835
Entamoeba histolytica	hypothetical protein	0.0034	0.0147	0.0835
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0028	0.0103	0.0857
Brugia malayi	SRC-1	0.0058	0.0326	0.033
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	tyrosine protein kinase HCK	0.004	0.0194	0.0192
Brugia malayi	Fibronectin type III domain containing protein	0.0016	0.0014	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Entamoeba histolytica	protein kinase, putative	0.0015	0.001	0.005
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Echinococcus granulosus	oxysterol binding protein 9	0.0028	0.0103	0.0101
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.003
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0251	0.1742	0.1742
Schistosoma mansoni	goodpasture antigen-binding protein	0.0028	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Brugia malayi	PXA domain containing protein	0.0251	0.1742	0.1773
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Echinococcus granulosus	Pleckstrin y	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Schistosoma mansoni	adapter molecule crk	0.0018	0.0031	0.0031
Entamoeba histolytica	PH domain containing protein	0.0028	0.0103	0.0581
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0023	0.0067	0.0065
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0058	0.0326	0.0324
Entamoeba histolytica	p21-activated kinase	0.0034	0.0147	0.0835
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0034	0.0147	1
Leishmania major	protein kinase, putative	0.0034	0.0147	1
Echinococcus granulosus	c src tyrosine kinase	0.0023	0.0067	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Echinococcus granulosus	twitchin	0.002	0.0047	0.0046
Echinococcus granulosus	Rho GTPase activating protein 24	0.0028	0.0103	0.0101
Onchocerca volvulus	Protein melted homolog	0.0028	0.0103	0.0857
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.1742	0.1742
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0034	0.0147	1
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.1742	0.1742
Echinococcus granulosus	cytohesin 1	0.0028	0.0103	0.0101
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0037	0.017	0.0168
Schistosoma mansoni	goodpasture antigen-binding protein	0.0028	0.0103	0.0103
Onchocerca volvulus		0.0015	0.0009	0.006
Brugia malayi	A-kinase anchor protein 10, precursor	0.0251	0.1742	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0034	0.0147	1
Schistosoma mansoni	hypothetical protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	PXA domain-containing protein	0.0251	0.1742	0.1741
Brugia malayi	regulator of G-protein signaling rgs-7	0.0251	0.1742	0.1773
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0058	0.0326	0.0324
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0028	0.0103	0.0101
Brugia malayi	Syntrophin-1	0.0028	0.0103	0.0103
Echinococcus granulosus	NCK adaptor protein	0.0018	0.0031	0.003
Echinococcus granulosus	Regulator of G protein signaling 20	0.0251	0.1742	0.1741
Onchocerca volvulus		0.0028	0.0103	0.0857
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0028	0.0103	0.0581
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0049	0.026	0.0259
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Echinococcus granulosus	Pleckstrin y	0.0028	0.0103	0.0101
Entamoeba histolytica	hypothetical protein	0.0034	0.0147	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0012
Schistosoma mansoni	rho gtpase activating protein	0.0028	0.0103	0.0103
Schistosoma mansoni	myotubularin-related protein	0.0028	0.0103	0.0103
Echinococcus granulosus	GRB2 associated binding protein 3	0.0028	0.0103	0.0101
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1374	1	1
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0034	0.0147	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0028	0.0103	0.0101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0014	0.0012
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0028	0.0103	0.0101
Echinococcus granulosus	regulator of G protein signaling 7	0.0251	0.1742	0.1741
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0028	0.0103	0.0857
Entamoeba histolytica	hypothetical protein	0.0251	0.1742	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0147	0.0835
Entamoeba histolytica	hypothetical protein, conserved	0.0028	0.0103	0.0581
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0044	0.0225	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0028
Schistosoma mansoni	syntrophin	0.0028	0.0103	0.0103
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0034	0.0147	1
Loa Loa (eye worm)	TK protein kinase	0.004	0.0194	0.0192
Loa Loa (eye worm)	RGS-3 protein	0.0251	0.1742	0.1741
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0023	0.0067	0.0065
Onchocerca volvulus	Putative zinc finger protein	0.0028	0.0103	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Schistosoma mansoni	tyrosine kinase	0.0014	0.0002	0.0002
Echinococcus granulosus	myotubularin protein 13	0.0028	0.0103	0.0101
Brugia malayi	Cadps2 protein	0.0028	0.0103	0.0103
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0034	0.0147	1
Onchocerca volvulus		0.0028	0.0103	0.0857
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0028	0.0103	0.0101
Echinococcus granulosus	serine/threonine protein kinase	0.0034	0.0147	0.0145
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0034	0.0147	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0034	0.0147	0.0147
Brugia malayi	Tyrosine-protein kinase abl-1	0.0023	0.0067	0.0066
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0009	0.0007
Brugia malayi	Variant SH3 domain containing protein	0.0037	0.017	0.0171
Entamoeba histolytica	protein kinase, putative	0.0034	0.0147	0.0835
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0034	0.0147	1
Schistosoma mansoni	dynamin	0.0028	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Loa Loa (eye worm)	rho-GTPase-activating	0.0028	0.0103	0.0101
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0037	0.0168	0.0166
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0058	0.0326	0.0324
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1098	0.7972	0.8122
Echinococcus granulosus	oxysterol binding protein 1	0.0028	0.0103	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Entamoeba histolytica	PH domain containing protein	0.0028	0.0103	0.0581
Leishmania major	serine/threonine-protein kinase a, putative	0.0034	0.0147	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0018	0.0031	0.003
Brugia malayi	Uncoordinated protein 104	0.0028	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0028	0.0103	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0018	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0012
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0251	0.1742	0.1773
Schistosoma mansoni	zinc finger protein	0.0028	0.0103	0.0103
Brugia malayi	Variant SH3 domain containing protein	0.0028	0.0103	0.0103
Echinococcus granulosus	beta 1 syntrophin	0.0028	0.0103	0.0101
Entamoeba histolytica	hypothetical protein	0.0037	0.0168	0.0955
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.1742	0.1742
Entamoeba histolytica	hypothetical protein	0.0251	0.1742	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Echinococcus multilocularis	oxysterol binding protein 3	0.0028	0.0103	0.0101
Echinococcus multilocularis	beta 1 syntrophin	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1742	0.1741
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0023	0.0067	0.0067
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1098	0.7972	0.7972
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0058	0.0326	0.0324
Brugia malayi	hypothetical protein	0.0016	0.0014	0.0012
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0028	0.0103	0.0101
Echinococcus multilocularis	regulator of G protein signaling 7	0.0251	0.1742	0.1741
Echinococcus multilocularis	neuroglian	0.0014	0.0003	0.0001
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Schistosoma mansoni	dynamin	0.0028	0.0103	0.0103
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0058	0.0326	0.0324
Schistosoma mansoni	tyrosine kinase	0.0014	0.0002	0.0002
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0041	0.0041
Brugia malayi	Sex muscle abnormal protein 5	0.0018	0.0031	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Schistosoma mansoni	growth factor receptor-bound protein	0.0018	0.0031	0.0031
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Echinococcus multilocularis	NCK adaptor protein	0.0018	0.0031	0.003
Brugia malayi	Oxysterol-binding protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1374	1	1
Onchocerca volvulus		0.0167	0.1124	0.9519
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0326	0.0324
Schistosoma mansoni	serine/threonine protein kinase	0.1374	1	1
Brugia malayi	Oxysterol binding protein	0.0028	0.0103	0.0103
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0034	0.0147	1
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0034	0.0147	1
Onchocerca volvulus		0.0028	0.0103	0.0857
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0034	0.0147	0.027
Schistosoma mansoni	nephrin	0.0018	0.0035	0.0035
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0028	0.0103	0.0101
Echinococcus multilocularis	dynamin 1	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0012
Echinococcus multilocularis	myotubularin protein 13	0.0028	0.0103	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Onchocerca volvulus		0.0028	0.0103	0.0857
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0147	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Schistosoma mansoni	z-protein (S1r protein)	0.0251	0.1742	0.1742
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0034	0.0147	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Entamoeba histolytica	protein kinase, putative	0.0034	0.0147	0.0835
Brugia malayi	MAX-1A	0.0028	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1742	0.1741
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0028	0.0103	0.0581
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0028
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0251	0.1742	0.1741
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0326	0.0324
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0028	0.0103	0.0101
Brugia malayi	TBC domain containing protein	0.0028	0.0103	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Schistosoma mansoni	growth factor receptor-bound protein	0.0018	0.0031	0.0031
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0028	0.0103	0.0581
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0326	0.0324
Schistosoma mansoni	oxysterol-binding protein 1	0.0028	0.0103	0.0103
Echinococcus multilocularis	pdz domain containing protein	0.0028	0.0103	0.0101
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.026	0.0259
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0028	0.0103	0.0101
Echinococcus multilocularis	axis inhibition protein axin	0.0251	0.1742	0.1741
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0028	0.0103	0.0101
Schistosoma mansoni	zinc finger protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	Pleckstrin y	0.0028	0.0103	0.0101
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0251	0.1742	0.1773
Trypanosoma brucei	protein kinase, putative	0.0034	0.0147	1
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Entamoeba histolytica	PH domain containing protein	0.0028	0.0103	0.0581
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0058	0.0326	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Echinococcus granulosus	regulator of G protein signaling 3	0.0251	0.1742	0.1741
Leishmania major	protein kinase, putative	0.0034	0.0147	1
Echinococcus multilocularis	Pleckstrin y	0.0028	0.0103	0.0101
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0251	0.1742	0.1741
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.1742	1
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.1742	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0049	0.026	0.0259
Brugia malayi	hypothetical protein	0.0251	0.1742	0.1773
Onchocerca volvulus	Tyrosine kinase homolog	0.0174	0.1181	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0049	0.026	0.0259
Echinococcus multilocularis	Oxysterol binding protein 11	0.0028	0.0103	0.0101
Echinococcus multilocularis	axis inhibition protein axin	0.0251	0.1742	0.1741
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0147	0.0835
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0326	0.0324
Brugia malayi	Pleckstrin Homology Domain	0.0028	0.0103	0.0103
Brugia malayi	Plekhf2 protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	cytohesin 1	0.0028	0.0103	0.0101
Schistosoma mansoni	growth factor receptor-bound protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	oxysterol binding protein	0.0028	0.0103	0.0101
Echinococcus granulosus	dynamin 1	0.0028	0.0103	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Schistosoma mansoni	serine/threonine-protein kinase	0.0034	0.0147	0.0147
Loa Loa (eye worm)	Plekhf2 protein	0.0028	0.0103	0.0101
Schistosoma mansoni	vav2	0.0037	0.017	0.017
Echinococcus granulosus	axis inhibition protein axin	0.0251	0.1742	0.1741
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0023	0.0067	0.0065
Schistosoma mansoni	nck2/grb4	0.0018	0.0031	0.0031
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0034	0.0147	1
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0028	0.0103	0.0101
Echinococcus multilocularis	expressed protein	0.0251	0.1742	0.1741
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0044	0.0225	0.0223
Echinococcus granulosus	axis inhibition protein axin	0.0251	0.1742	0.1741
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.1098	0.7972	0.7972
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1742	0.1741
Schistosoma mansoni	serine/threonine protein kinase	0.1349	0.9815	0.9815
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0034	0.0147	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Echinococcus multilocularis	regulator of G protein signaling	0.0251	0.1742	0.1741
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1742	0.1741
Brugia malayi	PXA domain containing protein	0.0251	0.1742	0.1773
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0018	0.0031	0.003
Echinococcus multilocularis	actin binding protein anillin	0.0028	0.0103	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0028	0.0103	0.0101
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0028	0.0103	0.0581
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0037	0.0168	0.0168
Brugia malayi	probable spectrin beta chain	0.0028	0.0103	0.0103
Echinococcus multilocularis	oxysterol binding protein 1	0.0028	0.0103	0.0101
Trypanosoma cruzi	NIMA-related kinase, putative	0.0034	0.0147	1
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0034	0.0147	1
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	c src tyrosine kinase	0.0023	0.0067	0.0065
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0028	0.0103	0.0103
Trypanosoma cruzi	Protein kinase B	0.0034	0.0147	1
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.1098	0.7972	0.7972
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Echinococcus multilocularis	regulator of G protein signaling 3	0.0251	0.1742	0.1741
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Echinococcus granulosus	DCC interacting protein 13 beta	0.0028	0.0103	0.0101
Echinococcus granulosus	Pleckstrin y	0.0028	0.0103	0.0101
Entamoeba histolytica	protein kinase, putative	0.0034	0.0147	0.0835
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0028	0.0103	0.0101
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0015	0.001	0.005
Echinococcus granulosus	tyrosine kinase	0.0049	0.026	0.0259
Entamoeba histolytica	protein kinase, putative	0.0034	0.0147	0.0835
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1124	0.8157	0.8157
Entamoeba histolytica	hypothetical protein	0.0028	0.0103	0.0581
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0251	0.1742	0.1742
Echinococcus multilocularis	roundabout 2	0.0022	0.0062	0.006
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0186	0.1269	0.1268
Echinococcus multilocularis	Pleckstrin y	0.0028	0.0103	0.0101
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0058	0.0326	0.0324
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0017	0.0023	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0034	0.0147	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0028	0.0103	0.0101
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.1742	0.1742
Entamoeba histolytica	hypothetical protein	0.0028	0.0103	0.0581
Echinococcus multilocularis	regulator of G protein signaling 3	0.0251	0.1742	0.1741
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Onchocerca volvulus	outspread protein homolog	0.0028	0.0103	0.0857
Schistosoma mansoni	tyrosine kinase	0.0023	0.0067	0.0067
Schistosoma mansoni	centaurin alpha	0.0028	0.0103	0.0103
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0064	0.037	0.0368
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0031	0.003
Loa Loa (eye worm)	TK protein kinase	0.0049	0.026	0.0259
Schistosoma mansoni	hypothetical protein	0.0028	0.0103	0.0103
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1349	0.9815	1
Brugia malayi	hypothetical protein	0.0251	0.1742	0.1773
Entamoeba histolytica	hypothetical protein	0.0028	0.0103	0.0581
Loa Loa (eye worm)	syntrophin-1	0.0028	0.0103	0.0101
Loa Loa (eye worm)	SRC-1	0.0058	0.0326	0.0324
Echinococcus granulosus	pdz domain containing protein	0.0028	0.0103	0.0101
Brugia malayi	Dynamin	0.0028	0.0103	0.0103
Echinococcus granulosus	neuroglian	0.0014	0.0003	0.0001
Brugia malayi	regulator of G-protein signaling egl-10	0.0251	0.1742	0.1773
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0034	0.0147	0.027
Schistosoma mansoni	hypothetical protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	uncoordinated protein 104	0.0028	0.0103	0.0101
Schistosoma mansoni	tyrosine kinase	0.0058	0.0326	0.0326
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0251	0.1742	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.1098	0.7972	0.7972
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0326	0.0324
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0147	0.0835
Onchocerca volvulus		0.0028	0.0103	0.0857
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.1742	1
Leishmania major	folate/biopterin transporter, putative	0.0034	0.0147	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Brugia malayi	PH domain containing protein	0.0028	0.0103	0.0103
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0186	0.1269	0.1292
Schistosoma mansoni	tyrosine kinase	0.0023	0.0067	0.0067
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0147	0.0835
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0028	0.0103	0.0101
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0031	0.003
Echinococcus granulosus	tyrosine protein kinase HCK	0.004	0.0194	0.0192
Brugia malayi	Dynamin	0.0028	0.0103	0.0103
Echinococcus granulosus	pleckstrin y domain containing family A	0.0028	0.0103	0.0101
Echinococcus granulosus	roundabout 2	0.0022	0.0062	0.006
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0028	0.0103	0.0581
Entamoeba histolytica	protein kinase, putative	0.004	0.0194	0.1103
Toxoplasma gondii	protein kinase domain-containing protein	0.0034	0.0147	1
Loa Loa (eye worm)	cytohesin 3	0.0028	0.0103	0.0101
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0251	0.1742	0.1742
Brugia malayi	Cytohesin 3	0.0028	0.0103	0.0103
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0028	0.0103	0.0101
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0034	0.0147	0.0145
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0251	0.1742	0.1741
Echinococcus granulosus	growth factor receptor bound protein 2	0.0018	0.0031	0.003
Entamoeba histolytica	protein kinase, putative	0.0034	0.0147	0.0835
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.1742	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0147	0.027
Onchocerca volvulus		0.0028	0.0103	0.0857
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0037	0.017	0.0168
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0049	0.026	0.0259
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0028	0.0103	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.1742	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0034	0.0147	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0058	0.0326	0.0324
Echinococcus multilocularis	regulator of G protein signaling 7	0.0251	0.1742	0.1741
Echinococcus multilocularis	oxysterol binding protein 9	0.0028	0.0103	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0101
Schistosoma mansoni	hypothetical protein	0.0028	0.0103	0.0103
Schistosoma mansoni	tyrosine kinase	0.0058	0.0326	0.0326
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.0007
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1124	0.8157	0.8157
Echinococcus granulosus	regulator of G protein signaling 3	0.0251	0.1742	0.1741
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0028	0.0103	0.0103
Echinococcus granulosus	regulator of G protein signaling 7	0.0251	0.1742	0.1741

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 137 nM	Inhibition of TIE2 (unknown origin)	ChEMBL.	23566514
IC50 (binding)	> 3000 nM	Inhibition of SRC (unknown origin)	ChEMBL.	23566514
IC50 (binding)	> 3000 nM	Inhibition of LCK (unknown origin)	ChEMBL.	23566514
IC50 (binding)	> 3000 nM	Inhibition of KDR (unknown origin)	ChEMBL.	23566514

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2387003

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1780645