Detailed information for compound 1798734

Basic information

Technical information
  • TDR Targets ID: 1798734
  • Name: SPECTRUM100005
  • MW: 480.549 | Formula: C28H32O7
  • H donors: 1 H acceptors: 4 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@H]1C[C@@]2(C)[C@@H](C[C@@H]3[C@@]2([C@]2(C1[C@@]1(C)C=CC(=O)C(C1=C(C2=O)O)(C)C)C)O3)c1ccoc1
  • InChi: 1S/C28H32O7/c1-14(29)34-17-12-26(5)16(15-8-10-33-13-15)11-19-28(26,35-19)27(6)21(17)25(4)9-7-18(30)24(2,3)22(25)20(31)23(27)32/h7-10,13,16-17,19,21,31H,11-12H2,1-6H3/t16-,17+,19+,21?,25+,26-,27-,28+/m0/s1
  • InChiKey: AJTULIWKBMDPCJ-IYGCLJFQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • BSPBio_001605
  • Spectrum5_000005
  • SPBio_000269
  • KBioSS_000966
  • Spectrum2_000225
  • KBioGR_001625
  • KBio3_000685
  • KBio1_001043
  • SpecPlus_000003
  • KBio2_000966
  • KBio2_003534
  • KBio2_006102
  • SDCCGMLS-0066334.P001
  • DivK1c_006099
  • Spectrum3_000003
  • Spectrum_000486
  • Spectrum4_001283

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier organic anion transporter family, member 1B3 Starlite/ChEMBL References
Homo sapiens solute carrier organic anion transporter family, member 1B1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi sodium-independent organic anion transporter family protein solute carrier organic anion transporter family, member 1B1 691 aa 634 aa 27.3 %
Brugia malayi sodium-independent organic anion transporter family protein solute carrier organic anion transporter family, member 1B3 702 aa 652 aa 28.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Loa Loa (eye worm) hypothetical protein 0.0046 0.043 0.1348
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0233 0.2779
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0233 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0025 0.0026
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0031 0.0054
Schistosoma mansoni sugar transporter 0.0029 0.0233 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Schistosoma mansoni amine GPCR 0.0049 0.0467 0.0466
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.033 0.1035
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0116 0.0363
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.0449 0.7179
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0755 0.3262
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Schistosoma mansoni follistatin 0.0046 0.0428 0.0425
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.018 0.0186
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.018 0.0522
Brugia malayi beta-lactamase 0.0075 0.0761 0.2353
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0048 0.0047
Echinococcus multilocularis geminin 0.0847 0.9651 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0204 0.064
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0233 0.0956
Schistosoma mansoni adenoreceptor 0.0049 0.0467 0.0466
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0467 0.0484
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0467 0.5979
Leishmania major hypothetical protein, conserved 0.0025 0.0182 0.0247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Brugia malayi nuclear receptor RXR 0.0013 0.0047 0.0104
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0467 0.0484
Brugia malayi follicle stimulating hormone receptor 0.0049 0.0467 0.1429
Leishmania major DNA polymerase eta, putative 0.0019 0.0116 0.0148
Schistosoma mansoni ap endonuclease 0.0037 0.033 0.0323
Brugia malayi Cathepsin L-like precursor 0.002 0.0131 0.037
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0467 0.0466
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.018 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.018 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni peptidase 0.0011 0.0021 0.0003
Schistosoma mansoni lamin 0.0027 0.0204 0.0193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0018 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0972 0.1007
Schistosoma mansoni glucose transport protein 0.0207 0.2278 0.2346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Loa Loa (eye worm) ctsf protein 0.002 0.0131 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.018 0.0563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0582 0.0603
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0467 0.1466
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0582 0.0603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0449 0.0646
Schistosoma mansoni sugar transporter 0.0029 0.0233 0.0223
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0467 0.0466
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0031 0.0013
Onchocerca volvulus 0.0014 0.0054 0.0319
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.028 0.3535
Echinococcus granulosus geminin 0.0847 0.9651 1
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0032 0.0045
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0031 0.0032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.2278 0.2361
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.018 0.0167
Brugia malayi hypothetical protein 0.0025 0.0182 0.0528
Onchocerca volvulus 0.0049 0.0467 0.5979
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.0192 0.0601
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0612 0.8006
Onchocerca volvulus 0.0049 0.0467 0.5979
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0755 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0131 0.0136
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Echinococcus multilocularis neuropeptide s receptor 0.0049 0.0467 0.0484
Schistosoma mansoni protein kinase 0.0063 0.0627 0.0632
Echinococcus granulosus tumor protein p63 0.0408 0.4599 0.4765
Brugia malayi GnHR receptor homolog 0.0049 0.0467 0.1429
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0067 0.0674 0.0699
Schistosoma mansoni biogenic amine receptor 0.0049 0.0467 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0131 0.0412
Echinococcus granulosus solute carrier family 22 0.0029 0.0233 0.0242
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0755 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus multilocularis cysteine protease 0.002 0.0131 0.0136
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0131 0.037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0467 0.1429
Trypanosoma cruzi MFS transporter, putative 0.0067 0.0674 0.0984
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0637 0.274
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0628 0.0925
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0761 0.138
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0182 0.0249
Schistosoma mansoni ap endonuclease 0.0037 0.033 0.0323
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0227 0.0711
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0046 0.0428 0.0623
Mycobacterium ulcerans hypothetical protein 0.0311 0.3481 1
Loa Loa (eye worm) DR-78 0.0012 0.0031 0.0097
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0067 0.0674 0.2115
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0467 0.0484
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0628 0.061
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Leishmania major protein kinase, putative 0.0063 0.0627 0.0913
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.018 0.0563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.043 0.6849
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0131 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0031 0.0013
Brugia malayi hypothetical protein 0.0013 0.0047 0.0104
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0755 0.1117
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0467 0.0484
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0628 0.061
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0047 0.0049
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0637 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.018 0.0522
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0755 0.3262
Onchocerca volvulus 0.0067 0.0674 0.8812
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.018 0.0522
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.033 0.0342
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.2278 0.2361
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0151 0.2978
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni agrin 0.0046 0.0428 0.0425
Brugia malayi nuclear hormone receptor 0.0024 0.018 0.0522
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0116 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Brugia malayi hypothetical protein 0.0029 0.0233 0.0691
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0018 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0577 0.0848
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Onchocerca volvulus Putative organic anion transporter 0.0067 0.0674 0.8812
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0233 0.0624
Loa Loa (eye worm) hypothetical protein 0.0067 0.0674 0.2115
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0449 0.5846
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0116 0.0101
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0032 0.0023
Echinococcus multilocularis solute carrier family 22 0.0029 0.0233 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0761 0.1113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0467 0.0484
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.018 0.0167
Echinococcus granulosus sex peptide receptor 0.0049 0.0467 0.0484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0972 0.1007
Onchocerca volvulus 0.0049 0.0467 0.5979
Echinococcus granulosus orexin receptor type 2 0.0049 0.0467 0.0484
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Echinococcus granulosus g protein coupled receptor 0.0049 0.0467 0.0484
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0855 0.1254
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0032 0.0014
Schistosoma mansoni amine GPCR 0.0049 0.0467 0.0466
Leishmania major cathepsin L-like protease 0.002 0.0131 0.0171
Onchocerca volvulus 0.0049 0.0467 0.5979
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0449 0.191
Leishmania major cathepsin L-like protease 0.002 0.0131 0.0171
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.2387
Brugia malayi cathepsin L-like precursor 0.0014 0.0054 0.0128
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.043 0.0427
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0467 0.1466
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2278 0.2361
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4574 0.4739
Trypanosoma brucei mitochondrial DNA polymerase beta 0.059 0.67 1
Brugia malayi intermediate filament protein 0.0027 0.0204 0.06
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.018 0.0167
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0467 0.0466
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0627 0.065
Plasmodium falciparum protein kinase 7 0.0584 0.6623 0.6617
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0449 0.0465
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0467 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0628 0.0925
Brugia malayi Sugar transporter family protein 0.0207 0.2278 0.7135
Onchocerca volvulus 0.0058 0.0569 0.7377
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0467 0.0466
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0665 0.8711
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.035 0.0617
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0467 0.0484
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0031 0.0054
Echinococcus granulosus g protein coupled receptor 0.0049 0.0467 0.0484
Onchocerca volvulus 0.0049 0.0467 0.5979
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0467 0.0484
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.018 0.0186
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0054 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.033 0.0469
Loa Loa (eye worm) hypothetical protein 0.0067 0.0674 0.2115
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0467 0.0484
Echinococcus multilocularis lamin dm0 0.0027 0.0204 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0116 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.018 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.018 0.0522
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0364 0.1536
Onchocerca volvulus 0.0049 0.0467 0.5979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0612 0.0635
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0334 0.3744 0.5643
Schistosoma mansoni survival motor neuron protein 0.0058 0.0569 0.0572
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4574 0.4739
Schistosoma mansoni histamine h1 receptor 0.0049 0.0467 0.0466
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0047 0.003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0755 0.1104
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Onchocerca volvulus 0.0029 0.0233 0.2768
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0449 0.0465
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2278 0.2361
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0007
Entamoeba histolytica hypothetical protein 0.0046 0.043 0.5586
Schistosoma mansoni pyruvate kinase 0.0033 0.028 0.0271
Loa Loa (eye worm) hypothetical protein 0.0023 0.0164 0.0516
Onchocerca volvulus 0.002 0.0131 0.1374
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0116 0.1324
Onchocerca volvulus 0.0075 0.0761 1
Echinococcus granulosus cathepsin L 0.001 0.0018 0.0019
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0612 0.0617
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0467 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.018 0.0522
Trypanosoma brucei cytochrome P450, putative 0.0015 0.007 0.0079
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0151 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0467 0.0484
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0628 0.061
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0612 0.0635
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0761 0.2387
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0449 0.0646
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0467 0.0484
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0046 0.0428 0.0623
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0233 0.0691
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0467 0.0484
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.018 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0116 0.012
Brugia malayi putative neuropeptide receptor 0.0049 0.0467 0.1429
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0761 0.0771
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0116 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0761 0.138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0467 0.0484
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0233 0.0223
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.0449 0.0465
Loa Loa (eye worm) hypothetical protein 0.0048 0.0449 0.1408
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0116 0.0184
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Echinococcus granulosus intermediate filament protein 0.0027 0.0204 0.0211
Echinococcus granulosus neuropeptide receptor 0.0049 0.0467 0.0484
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2278 0.2361
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.043 0.0445
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0032 0.0034
Echinococcus granulosus neuropeptide receptor 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus multilocularis pyruvate kinase 0.0026 0.0199 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0047 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0116 0.0322
Echinococcus granulosus serotonin receptor 0.0049 0.0467 0.0484
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0761 0.2148
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0755 0.1104
Onchocerca volvulus 0.002 0.0131 0.1374
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0233 0.0956
Onchocerca volvulus 0.0029 0.0233 0.2768
Trichomonas vaginalis esterase, putative 0.0075 0.0761 0.329
Schistosoma mansoni inositol monophosphatase 0.0074 0.0755 0.0764
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0018 0.0003
Echinococcus granulosus lamin 0.0027 0.0204 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.043 0.1192
Brugia malayi SPARC precursor 0.0046 0.0428 0.1305
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0577 0.0838
Echinococcus granulosus dna polymerase eta 0.0019 0.0116 0.012
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0116 0.0286
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 0.0163
Toxoplasma gondii exonuclease III APE 0.0037 0.033 0.0474
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0467 0.0484
Schistosoma mansoni sugar transporter 0.0029 0.0233 0.0223
Leishmania major pyruvate kinase 0.0033 0.028 0.0394
Echinococcus multilocularis pyruvate kinase 0.0017 0.0094 0.0098
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.018 0.0167
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0127
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0233 0.0324
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0467 0.0466
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0233 0.0324
Onchocerca volvulus 0.0029 0.0233 0.2768
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.018 0.0186
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0449 0.191
Giardia lamblia Hexose transporter 0.0029 0.0233 0.346
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.018 0.2036
Onchocerca volvulus 0.0067 0.0674 0.8812
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0031 0.0097
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0467 0.1466
Schistosoma mansoni thyroid hormone receptor 0.0024 0.018 0.0167
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0577 0.1039
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.018 0.0186
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0032 0.0029
Plasmodium falciparum mitogen-activated protein kinase 2 0.0334 0.3744 0.3733
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0628 0.061
Plasmodium vivax vivapain-2 0.002 0.0131 0.0113
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.033 0.1385
Brugia malayi Cytochrome P450 family protein 0.0015 0.007 0.0176
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.033 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0018 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Brugia malayi secreted modular calcium-binding protein 1 0.0046 0.0428 0.1305
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Onchocerca volvulus 0.0049 0.0467 0.5979
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0637 0.274
Brugia malayi nuclear receptor RXR 0.0012 0.0031 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Onchocerca volvulus 0.0029 0.0233 0.2768
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0467 0.0484
Plasmodium vivax hexose transporter 0.0207 0.2278 0.2264
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0467 0.0484
Onchocerca volvulus 0.0075 0.0761 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0467 0.0484
Mycobacterium tuberculosis Conserved protein 0.0075 0.0761 0.138
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0018 0.0003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0467 0.0466
Loa Loa (eye worm) sugar transporter 0.0029 0.0233 0.0731
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0031 0.0032
Schistosoma mansoni opsin-like receptor 0.0049 0.0467 0.0466
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0031 0.0054
Plasmodium vivax vivapain-2 0.002 0.0131 0.0113
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0467 0.1466
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0628 0.061
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.033 0.0996
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.018 0.0186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0577 0.1617
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0755 0.213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0054 0.0166
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0786 0.1151
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0032 0.0034
Echinococcus multilocularis follistatin 0.0046 0.0428 0.0444
Onchocerca volvulus 0.0049 0.0467 0.5979
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0032 0.0023
Echinococcus granulosus solute carrier family 22 0.0029 0.0233 0.0242
Brugia malayi G protein-coupled receptor 0.0049 0.0467 0.1429
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0467 0.0484
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.043 0.0618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0972 0.099
Leishmania major cathepsin L-like protease 0.0077 0.0786 0.1151
Brugia malayi hypothetical protein 0.0067 0.0674 0.208
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0233 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.018 0.0522
Onchocerca volvulus Cathepsin F homolog 0.002 0.0131 0.1374
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9498 0.9841
Brugia malayi Cam kinase protein 1 0.0063 0.0627 0.1932
Plasmodium vivax sugar transporter, putative 0.0029 0.0233 0.0215
Trypanosoma cruzi cysteine protease, putative 0.001 0.0018 0.0003
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0637 0.0927
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.035 0.0617
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0731 0.0714
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0467 0.0466
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0116 0.0148
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0449 0.137
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0761 0.0788
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0032 0.0058
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.028 0.0398
Leishmania major cysteine peptidase A (CPA) 0.002 0.0131 0.0171
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.028 0.3408
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0047 0.0104
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.059 0.67 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Schistosoma mansoni opsin-like receptor 0.0049 0.0467 0.0466
Echinococcus multilocularis cpg binding protein 0.003 0.0245 0.0254
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.007 0.0079
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0031 0.0032
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.028 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3188 0.3303
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Onchocerca volvulus 0.0028 0.0227 0.2681
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0018 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0467 0.0484
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0637 0.0927
Echinococcus granulosus g protein coupled receptor 0.0049 0.0467 0.0484
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0467 0.0484
Onchocerca volvulus 0.002 0.0131 0.1374
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0761 0.0788
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0467 0.1466
Schistosoma mansoni cpg binding protein 0.003 0.0245 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.033 0.513
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0131 0.0117
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0569
Schistosoma mansoni myosin xvIII 0.0049 0.0467 0.0466
Loa Loa (eye worm) hypothetical protein 0.005 0.0479 0.1501
Onchocerca volvulus 0.0049 0.0467 0.5979
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0972 0.1007
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0032 0.0034
Toxoplasma gondii cathepsin CPL 0.002 0.0131 0.0173
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0755 0.1104
Loa Loa (eye worm) hypothetical protein 0.0286 0.3188 1
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0031 0.0054
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3188 0.3303
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.018 0.0186
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.018 0.0186
Entamoeba histolytica protein kinase, putative 0.0063 0.0627 0.8269
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0054 0.0488
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.028 0.3408
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0761 0.138
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.033 0.0581
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0127
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0467 0.1466
Echinococcus granulosus solute carrier family 22 0.0029 0.0233 0.0242
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.0449 0.0447
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0204 0.064
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0637 0.0927
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0031 0.0032
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0731 0.1081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0467 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Toxoplasma gondii sugar transporter ST2 0.0029 0.0233 0.0327
Echinococcus multilocularis dna polymerase eta 0.0019 0.0116 0.012
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0731 0.1068
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.018 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.018 0.0522
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0627 0.065
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Echinococcus multilocularis cysteine protease 0.002 0.0131 0.0136
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0612 0.8069
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.0247
Trypanosoma brucei glucose transporter 1E 0.0064 0.0637 0.0927
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0972 0.3018
Schistosoma mansoni hypothetical protein 0.0847 0.9651 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.2278 0.2361
Echinococcus multilocularis pyruvate kinase 0.0033 0.028 0.029
Leishmania major hypothetical protein, conserved 0.0029 0.0233 0.0324
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0761 0.329
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.018 0.0563
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0131 0.0412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0467 0.0484
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.028 0.0394
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0131 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Brugia malayi hypothetical protein 0.0016 0.0081 0.0212
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0755 0.0782
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0467 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0334 0.3744 0.3733
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0046 0.0428 0.0623
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0032 0.0014
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.043 0.0618
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0761 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0227 0.0671
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0972 0.1007
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.043 0.0427
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Brugia malayi neuropeptide F receptor 0.0049 0.0467 0.1429
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0031 0.0032
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0031 0.0054
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0233 0.0324
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.033 0.0312
Mycobacterium ulcerans pyruvate kinase 0.0033 0.028 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.018 0.0563
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0233 0.0731
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.028 0.0394
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9498 0.9842
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0116 0.012
Giardia lamblia Sugar-proton symporter 0.0029 0.0233 0.346
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0046 0.0428 0.1305
Onchocerca volvulus 0.0029 0.0233 0.2768
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0207 0.2278 0.2361
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.2387
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.018 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0627 0.065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Onchocerca volvulus 0.006 0.0586 0.761
Leishmania major cytochrome p450-like protein 0.0015 0.007 0.0079
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0204 0.064
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0786 0.1151
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0612 1
Schistosoma mansoni hypothetical protein 0.0049 0.0467 0.0466
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0233 0.0624
Onchocerca volvulus 0.002 0.0131 0.1374
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.0247
Echinococcus granulosus pyruvate kinase 0.0017 0.0094 0.0098
Loa Loa (eye worm) hypothetical protein 0.0067 0.0674 0.2115
Brugia malayi major facilitator superfamily protein 0.0029 0.0233 0.0691
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0116 0.0322
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0467 0.0484
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.028 0.0488
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0577 0.058
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.0449 0.0447
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0182 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0612 0.1886
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0101 0.1064 0.1567
Schistosoma mansoni DNA polymerase eta 0.0019 0.0116 0.0101
Echinococcus granulosus solute carrier family 22 0.0029 0.0233 0.0242
Mycobacterium ulcerans hypothetical protein 0.0075 0.0761 0.2148
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0025 0.0026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.018 0.0186
Onchocerca volvulus 0.0027 0.0204 0.2371
Echinococcus granulosus agrin 0.0046 0.0428 0.0444
Onchocerca volvulus 0.0067 0.0674 0.8812
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.0627 0.1967
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0046 0.0048
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.0627 0.065
Echinococcus granulosus pyruvate kinase 0.0017 0.0094 0.0098
Echinococcus multilocularis lamin 0.0027 0.0204 0.0211
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni cpg binding protein 0.0028 0.0227 0.0216
Onchocerca volvulus Cathepsin L homolog 0.002 0.0131 0.1374
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0233 0.0327
Toxoplasma gondii protease inhibitor PI2 0.0046 0.0428 0.0623
Brugia malayi sodium-independent organic anion transporter family protein 0.0067 0.0674 0.208
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0731 0.1068
Leishmania major glucose transporter, lmgt3 0.0064 0.0637 0.0927
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0046 0.0428 0.1343
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0637 0.274
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0596 0.0867
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.018 0.0522
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Onchocerca volvulus 0.0049 0.0467 0.5979
Brugia malayi Cathepsin L-like precursor 0.002 0.0131 0.037
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0204 0.06
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.033 0.0469
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0032 0.0069
Onchocerca volvulus 0.0046 0.0428 0.544
Onchocerca volvulus 0.0029 0.0233 0.2768
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0131 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0233 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0627 0.065
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0467 0.0484
Mycobacterium ulcerans sugar transporter 0.0029 0.0233 0.0624
Loa Loa (eye worm) hypothetical protein 0.0067 0.0674 0.2115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.018 0.0186
Onchocerca volvulus 0.0029 0.0233 0.2768
Echinococcus granulosus neuropeptide s receptor 0.0049 0.0467 0.0484
Brugia malayi major facilitator superfamily protein 0.0029 0.0233 0.0691
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Onchocerca volvulus 0.0029 0.0233 0.2768
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0467 0.0466
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.043 0.0625
Onchocerca volvulus 0.0049 0.0467 0.5979
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0147
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0054 0.0128
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0786 0.1151
Brugia malayi hypothetical protein 0.0029 0.0233 0.0691
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0031 0.0013
Echinococcus granulosus cpg binding protein 0.003 0.0245 0.0254
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0047 0.0049
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0131 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Brugia malayi hypothetical protein 0.0067 0.0674 0.208
Leishmania major mitochondrial DNA polymerase beta 0.059 0.67 1
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Onchocerca volvulus Putative organic anion transporter 0.0067 0.0674 0.8812
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0046 0.0428 0.1305
Schistosoma mansoni amine GPCR 0.0049 0.0467 0.0466
Echinococcus multilocularis sex peptide receptor 0.0049 0.0467 0.0484
Brugia malayi neuropeptide F receptor 0.0049 0.0467 0.1429
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0761 0.138
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0144
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0449 0.0465
Plasmodium falciparum hexose transporter 0.0207 0.2278 0.2264
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0586 0.059
Schistosoma mansoni amine GPCR 0.0049 0.0467 0.0466
Toxoplasma gondii transporter, major facilitator family protein 0.0067 0.0674 0.0995
Brugia malayi sodium-independent organic anion transporter family protein 0.0067 0.0674 0.208
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0032 0.0023
Brugia malayi hypothetical protein 0.0029 0.0233 0.0691
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0046 0.0428 0.1305
Trypanosoma brucei unspecified product 0.0019 0.0116 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0761 0.2148
Brugia malayi Cathepsin L-like precursor 0.0014 0.0054 0.0128
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0233 0.0401
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.043 0.1192
Plasmodium falciparum pyruvate kinase 0.0033 0.028 0.0262
Trypanosoma brucei glucose transporter 2A 0.0064 0.0637 0.0927
Loa Loa (eye worm) hypothetical protein 0.0046 0.0428 0.1343
Echinococcus granulosus Solute carrier organic anion transporter family 0.0067 0.0674 0.0699
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0467 0.0484
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0467 0.0484
Onchocerca volvulus 0.0049 0.0467 0.5979
Echinococcus multilocularis agrin 0.0046 0.0428 0.0444
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0577 0.1617
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0032 0.0023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0116 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0233 0.0956
Brugia malayi Cathepsin L-like precursor 0.002 0.0131 0.037
Loa Loa (eye worm) pyruvate kinase 0.0033 0.028 0.0878
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.028 0.3408
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Onchocerca volvulus 0.0029 0.0233 0.2768
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.018 0.0522
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0116 0.0148
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0467 0.0466
Brugia malayi steroid hormone receptor 0.0024 0.018 0.0522
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.018 0.0186
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus multilocularis solute carrier family 22 0.0029 0.0233 0.0242
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0164 0.0516
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.043 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0131 0.1374
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0627 0.2699
Schistosoma mansoni biogenic amine receptor 0.0049 0.0467 0.0466
Entamoeba histolytica protein kinase, putative 0.0063 0.0627 0.8269
Loa Loa (eye worm) hypothetical protein 0.0062 0.0612 0.1921
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Loa Loa (eye worm) cysteine protease 0.002 0.0131 0.0412
Schistosoma mansoni biogenic amine receptor 0.0049 0.0467 0.0466
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0637 0.0927
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0032 0.0101
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0094 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Plasmodium vivax CDK-related protein kinase 6, putative 0.0877 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0467 0.0484
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.059 0.67 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0094 0.0117
Loa Loa (eye worm) hypothetical protein 0.0067 0.0674 0.2115
Onchocerca volvulus 0.002 0.0131 0.1374
Loa Loa (eye worm) pyruvate kinase 0.0033 0.028 0.0878
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0164 0.1982
Brugia malayi hypothetical protein 0.0012 0.0031 0.0054
Schistosoma mansoni glucose transporter 0.0029 0.0233 0.0223
Echinococcus granulosus pyruvate kinase 0.0017 0.0094 0.0098
Brugia malayi Melatonin receptor type 1A 0.0049 0.0467 0.1429
Schistosoma mansoni hypothetical protein 0.0049 0.0467 0.0466
Loa Loa (eye worm) hypothetical protein 0.0046 0.0428 0.1343
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0018 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0182 0.0247
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0067 0.0674 0.0699
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0032 0.0189
Onchocerca volvulus 0.0029 0.0233 0.2768
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0467 0.0484
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0637 0.274
Echinococcus granulosus pyruvate kinase 0.0033 0.028 0.029
Leishmania major pyruvate kinase 0.0033 0.028 0.0394
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.033 0.0469
Schistosoma mansoni organic anion transporter 0.0067 0.0674 0.0681
Echinococcus granulosus dna polymerase kappa 0.0019 0.0116 0.012
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0467 0.1429
Mycobacterium tuberculosis Conserved protein 0.0075 0.0761 0.138
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0046 0.0428 0.0623
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.028 0.1163
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0637 0.274
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0031 0.0054
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0233 0.0242
Schistosoma mansoni inositol monophosphatase 0.0074 0.0755 0.0764
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0478 0.5408 1
Trypanosoma brucei unspecified product 0.0013 0.0048 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Brugia malayi beta-lactamase family protein 0.0075 0.0761 0.2353
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0412
Loa Loa (eye worm) CYP4Cod1 0.0015 0.007 0.0218
Onchocerca volvulus 0.0049 0.0467 0.5979
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.018 0.0186
Brugia malayi nuclear receptor NHR-88 0.0024 0.018 0.0522
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0627 0.065
Toxoplasma gondii protein kinase, putative 0.0584 0.6623 1
Brugia malayi Sugar transporter family protein 0.0029 0.0233 0.0691
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0731 0.1068
Echinococcus granulosus somatostatin receptor 0.0049 0.0467 0.0484
Brugia malayi G-protein coupled receptor 0.0049 0.0467 0.1429
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0233 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0628 0.061
Schistosoma mansoni hypothetical protein 0.0049 0.0467 0.0466
Brugia malayi Dopamine receptor protein 2 0.0049 0.0467 0.1429
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0855 0.1254
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Echinococcus multilocularis pyruvate kinase 0.0017 0.0094 0.0098
Onchocerca volvulus 0.0029 0.0233 0.2768
Trypanosoma cruzi hexose transporter 0.0064 0.0637 0.0927
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.018 0.0167
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0467 0.1466
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0467 0.0484
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0018 0.0015
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0032 0.0058
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.033 0.0342
Loa Loa (eye worm) hypothetical protein 0.0062 0.0612 0.1921
Onchocerca volvulus 0.0067 0.0674 0.8812
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0467 0.0484
Toxoplasma gondii sugar transporter ST1 0.0029 0.0233 0.0327
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0577 0.0598
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0449 0.0465
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni neuropeptide receptor 0.0049 0.0467 0.0466
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.018 0.0167
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0637 0.274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Entamoeba histolytica cysteine protease, putative 0.002 0.0131 0.1534
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Echinococcus multilocularis serotonin receptor 0.0049 0.0467 0.0484
Schistosoma mansoni opsin-like receptor 0.0049 0.0467 0.0466
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0467 0.0484
Mycobacterium tuberculosis Conserved protein 0.0075 0.0761 0.138
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0761 0.329
Giardia lamblia Pyruvate kinase 0.0033 0.028 0.4265
Schistosoma mansoni intermediate filament proteins 0.0027 0.0204 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Leishmania major cathepsin L-like protease 0.0077 0.0786 0.1151
Mycobacterium leprae Probable lipase LipE 0.0075 0.0761 1
Brugia malayi ecdysteroid receptor 0.0024 0.018 0.0522
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0032 0.0014
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0577 0.0598
Toxoplasma gondii ABC1 family protein 0.0075 0.0761 0.1126
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.018 0.2036
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.007 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.018 0.0522
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Schistosoma mansoni nuclear receptor 0.0012 0.0031 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0116 0.0286
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.018 0.0167
Echinococcus granulosus cysteine protease 0.001 0.0018 0.0019
Brugia malayi Cathepsin L-like precursor 0.002 0.0131 0.037
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0233 0.0401
Onchocerca volvulus 0.002 0.0131 0.1374
Mycobacterium ulcerans lipase LipD 0.0075 0.0761 0.2148
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0761 0.329
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.0449 0.0646
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.033 0.0312
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0467 0.0484
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0046 0.0048
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0467 0.0466
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0018 0.0015
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0731 0.0714
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.007 0.0218
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0116 0.0438
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.2387
Brugia malayi sulfakinin receptor protein 0.0049 0.0467 0.1429
Toxoplasma gondii hypothetical protein 0.0095 0.0995 0.1482
Onchocerca volvulus 0.0067 0.0674 0.8812
Loa Loa (eye worm) hypothetical protein 0.0046 0.0428 0.1343
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0467 0.0484
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0233 0.0731
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0094 0.0076
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Brugia malayi nuclear hormone receptor 0.0012 0.0031 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.052 0.0762
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0467 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0627 0.065
Echinococcus granulosus cathepsin l1 0.0014 0.0054 0.0056
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0032 0.0209
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0031 0.0013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.033 0.0904
Brugia malayi G-protein coupled receptor 0.0049 0.0467 0.1429
Loa Loa (eye worm) hypothetical protein 0.006 0.0586 0.184
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.0449 0.0465
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0171
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0637 0.0927
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0577 0.1617
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Leishmania major glucose transporter, lmgt1 0.0064 0.0637 0.0927
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0972 0.3049
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0131 0.0113
Loa Loa (eye worm) inositol-1 0.0074 0.0755 0.2367
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0755 0.0782
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.0627 0.1932
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0467 0.1466
Echinococcus granulosus neuropeptide receptor A26 0.0049 0.0467 0.0484
Onchocerca volvulus Putative organic anion transporter 0.0067 0.0674 0.8812
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.018 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0627 0.0632
Onchocerca volvulus 0.0049 0.0467 0.5979
Brugia malayi nuclear receptor NHR-67 0.0012 0.0031 0.0054
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0233 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0151 0.3976
Echinococcus granulosus follistatin 0.0046 0.0428 0.0444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Echinococcus multilocularis neuropeptide receptor A26 0.0049 0.0467 0.0484
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0233 0.0691
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0032 0.0014
Echinococcus granulosus hypothetical protein 0.0049 0.0467 0.0484
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0467 0.0484
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.043 0.0412
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0467 0.1466
Brugia malayi Serotonin receptor 0.0049 0.0467 0.1429
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0755 0.1104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0761 0.0771
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Schistosoma mansoni sugar transporter 0.0029 0.0233 0.0223
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0467 0.0484
Echinococcus granulosus cathepsin l1 0.002 0.0131 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0131 0.1534
Brugia malayi beta-lactamase family protein 0.0075 0.0761 0.2353
Schistosoma mansoni thyroid hormone receptor 0.0024 0.018 0.0167
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0067 0.0674 0.2115
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0467 0.0484
Trypanosoma brucei pyruvate kinase 1 0.0033 0.028 0.0394
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.0449 0.0646
Schistosoma mansoni zinc finger protein 0.0012 0.0031 0.0013
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.033 0.412
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0032 0.0058
Onchocerca volvulus 0.0049 0.0467 0.5979
Brugia malayi Dopamine receptor 0.0049 0.0467 0.1429
Trypanosoma brucei sugar transporter, putative 0.0029 0.0233 0.0324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0031 0.0032
Schistosoma mansoni hypothetical protein 0.0847 0.9651 1
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0031 0.0032
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0467 0.0484
Schistosoma mansoni glucose transport protein 0.0207 0.2278 0.2346
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.0627 0.1967
Brugia malayi Sugar transporter family protein 0.0029 0.0233 0.0691
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0046 0.0428 0.1305
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Brugia malayi hypothetical protein 0.0286 0.3188 1
Echinococcus multilocularis musashi 0.0027 0.0204 0.0211
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0731 0.1068
Brugia malayi AKH receptor 0.0049 0.0467 0.1429
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0467 0.5979
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0665 0.1202
Loa Loa (eye worm) pyruvate kinase 0.0033 0.028 0.0878
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0279 0.3117 0.4639
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0031 0.0032
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0131 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0755 0.3262
Onchocerca volvulus 0.0029 0.0233 0.2768
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0131 0.1534
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0467 0.0484
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0731 0.1068
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 0.0163
Mycobacterium ulcerans beta-lactamase 0.0075 0.0761 0.2148
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0046 0.0428 0.1343
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0031 0.0032
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0467 0.0484
Leishmania major hypothetical protein, conserved 0.0075 0.0761 0.1113
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0031 0.0032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0569 0.175
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Onchocerca volvulus 0.0029 0.0233 0.2768
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0047 0.0147
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0563
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.007 0.0218
Brugia malayi ORL1-like opioid receptor 0.0049 0.0467 0.1429
Schistosoma mansoni lamin 0.0027 0.0204 0.0193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.018 0.0563
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0047 0.0104
Schistosoma mansoni neuropeptide receptor 0.0049 0.0467 0.0466
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.033 0.4231
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.033 0.0469
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0131 0.0113
Schistosoma mansoni hypothetical protein 0.0406 0.4574 0.4729
Schistosoma mansoni hypothetical protein 0.0207 0.2278 0.2346
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0171
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.043 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.018 0.0563
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0628 0.061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0467 0.0466
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0761 0.1113
Echinococcus multilocularis expressed protein 0.0046 0.0428 0.0444
Echinococcus multilocularis solute carrier family 22 0.0029 0.0233 0.0242
Onchocerca volvulus Putative transporter 0.0029 0.0233 0.2768
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0467 0.1429
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0467 0.1429
Schistosoma mansoni pyruvate kinase 0.0017 0.0094 0.0079
Leishmania major cathepsin L-like protease 0.002 0.0131 0.0171
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0467 0.0484
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0032 0.0189
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni amine GPCR 0.0049 0.0467 0.0466
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0116 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Schistosoma mansoni nuclear hormone receptor 0.0024 0.018 0.0167
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.018 0.0563
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.0623
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0031 0.0032
Brugia malayi lysyl-tRNA synthetase 0.0046 0.043 0.131
Brugia malayi tailless protein 0.0012 0.0031 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0595 0.0598
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0131 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0972 0.099
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0233 0.0691
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Onchocerca volvulus 0.002 0.0131 0.1374
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0131 0.0171
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.018 0.2036
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0116 0.0148
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0628 0.061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.018 0.0186
Echinococcus multilocularis pyruvate kinase 0.0033 0.028 0.029
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0627 0.065
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0116 0.012
Onchocerca volvulus 0.0049 0.0467 0.5979
Trypanosoma brucei unspecified product 0.0013 0.0048 0.0047
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0116 0.0438
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0761 0.138
Loa Loa (eye worm) beta-lactamase 0.0075 0.0761 0.2387
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0467 0.1429
Echinococcus granulosus fmrfamide receptor 0.0049 0.0467 0.0484
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0467 0.0466
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0467 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0131 0.0507
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.2387
Leishmania major glucose transporter, lmgt2 0.0064 0.0637 0.0927
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0233 0.0956
Brugia malayi hypothetical protein 0.0012 0.0031 0.0054
Giardia lamblia Pyruvate kinase 0.0017 0.0094 0.1066
Brugia malayi nuclear receptor NHR-88 0.0012 0.0031 0.0054
Echinococcus granulosus General substrate transporter 0.0178 0.1944 0.2014
Onchocerca volvulus 0.0029 0.0233 0.2768
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0233 0.0624
Echinococcus granulosus pyruvate kinase 0.0033 0.028 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Onchocerca volvulus 0.0027 0.0204 0.2371
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trypanosoma brucei glucose transporter, putative 0.0064 0.0637 0.0927
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0761 0.1113
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.043 0.0412
Schistosoma mansoni hypothetical protein 0.0058 0.0569 0.0572
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0786 0.1151
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0032 0.0023
Echinococcus granulosus allatostatin A receptor 0.0049 0.0467 0.0484
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.043 0.5549
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0761 0.329
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.043 0.1826
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0031 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0116 0.0148
Chlamydia trachomatis pyruvate kinase 0.0033 0.028 0.6227
Brugia malayi Cathepsin L-like precursor 0.0014 0.0054 0.0128
Echinococcus multilocularis pyruvate kinase 0.0017 0.0094 0.0098
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Echinococcus multilocularis serotonin receptor 0.0049 0.0467 0.0484
Onchocerca volvulus 0.0075 0.0761 1
Echinococcus multilocularis somatostatin receptor 0.0049 0.0467 0.0484
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0628 0.061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.0449 0.191
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0637 0.274
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.018 0.0522
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0612 0.2634
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0233 0.0242
Schistosoma mansoni hypothetical protein 0.0049 0.0467 0.0466
Schistosoma mansoni glucose transport protein 0.0207 0.2278 0.2346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.018 0.0563
Echinococcus multilocularis solute carrier family 22 0.0029 0.0233 0.0242
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0131 0.0136
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Loa Loa (eye worm) sugar transporter 0.0207 0.2278 0.7147
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0233 0.0956
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9498 0.9842
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0062 0.0195
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.043 0.0445
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.0855 0.1254
Brugia malayi ecdysone receptor 0.0012 0.0031 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0131 0.0507
Onchocerca volvulus 0.0049 0.0467 0.5979
Brugia malayi Inositol-1 0.0074 0.0755 0.2334
Echinococcus granulosus lamin dm0 0.0027 0.0204 0.0211
Schistosoma mansoni nuclear receptor 0.0012 0.0031 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.018 0.0186
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0279 0.3117 0.4639
Schistosoma mansoni protein kinase 0.0063 0.0627 0.0632
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0363
Brugia malayi Serotonin receptor 0.0049 0.0467 0.1429
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0467 0.0466
Loa Loa (eye worm) fibroinase 0.002 0.0131 0.0412
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0761 0.138
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0761 0.2353
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0467 0.0484
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0302 0.0427
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0233 0.0324
Onchocerca volvulus 0.0029 0.0233 0.2768
Plasmodium vivax pyruvate kinase, putative 0.0033 0.028 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.018 0.0522
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0279 0.3117 0.4639
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.2387
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0467 0.1466
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0032 0.0101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0627 0.1967
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0062 0.0152
Schistosoma mansoni neuropeptide receptor 0.0049 0.0467 0.0466
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0467 0.0484
Schistosoma mansoni neuropeptide receptor 0.0049 0.0467 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.018 0.0522
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.028 0.0838
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.2278 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0467 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0131 0.0507
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Brugia malayi Cytochrome P450 family protein 0.0015 0.007 0.0176
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.035 0.4473
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0467 0.1429
Giardia lamblia DINP protein human, muc B family 0.0019 0.0116 0.144
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0709 0.1036
Brugia malayi Dopamine receptor protein 1 0.0049 0.0467 0.1429
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0467 0.0484
Schistosoma mansoni cpg binding protein 0.003 0.0245 0.0236
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0031 0.0097
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0067 0.0674 0.0699
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0628 0.0925
Brugia malayi prostaglandin transporter 0.0067 0.0674 0.208
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0467 0.0466
Brugia malayi sodium-independent organic anion transporter family protein 0.0067 0.0674 0.208
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.028 0.0838
Brugia malayi Cathepsin L-like precursor 0.002 0.0131 0.037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0311 0.3481 0.6426
Onchocerca volvulus 0.0024 0.018 0.2036
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0031 0.0032
Echinococcus multilocularis General substrate transporter 0.0178 0.1944 0.2014
Leishmania major cathepsin L-like protease 0.002 0.0131 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0018 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0972 0.099
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Schistosoma mansoni protein kinase 0.0063 0.0627 0.0632
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Leishmania major cathepsin L-like protease 0.002 0.0131 0.0171
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0031 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.0467 0.1466
Loa Loa (eye worm) hypothetical protein 0.0067 0.0674 0.2115
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0577 0.058
Schistosoma mansoni pyruvate kinase 0.0033 0.028 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0467 0.0484
Echinococcus granulosus FTZ F1 alpha 0.0024 0.018 0.0186
Toxoplasma gondii sugar transporter ST3 0.0029 0.0233 0.0327
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.007 0.0152
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0761 0.138
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0467 0.0484
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.018 0.0186
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0147
Brugia malayi larval opioid receptor 0.0049 0.0467 0.1429
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0467 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0131 0.0507
Toxoplasma gondii facilitative glucose transporter GT1 0.0207 0.2278 0.3424
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0147
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2278 0.2361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0467 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0054 0.0166
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.2387
Brugia malayi hypothetical protein 0.0013 0.0047 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0786 0.1151
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0032 0.0034
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0467 0.0484
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0467 0.0484
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0637 0.0927
Echinococcus multilocularis cathepsin L 0.001 0.0018 0.0019
Leishmania major cathepsin L-like protease 0.0077 0.0786 0.1151
Echinococcus multilocularis tumor protein p63 0.0408 0.4599 0.4765
Brugia malayi RE15519p 0.0049 0.0467 0.1429
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0467 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.018 0.0522
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0032 0.0045
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0032 0.0024
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0612 0.0617
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0855 0.1254
Schistosoma mansoni organic anion transporter 0.0067 0.0674 0.0681
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0612 0.1886
Schistosoma mansoni coup transcription factor 0.0024 0.018 0.0167
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0467 0.0484
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0761 0.0744
Brugia malayi Cathepsin L-like precursor 0.002 0.0131 0.037
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.028 0.1163
Loa Loa (eye worm) agrin synaptic family protein 0.0046 0.0428 0.1343
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0467 0.0466
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0467 0.1429
Brugia malayi hypothetical protein 0.0049 0.0467 0.1429
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0063 0.0627 0.0913
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0048 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0233 0.0956
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.033 0.1385
Onchocerca volvulus 0.0029 0.0233 0.2768
Brugia malayi conserved hypotetical protein 0.0012 0.0031 0.0054
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0467 0.0484
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0048 0.0047
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0233 0.0242
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0467 0.1429
Loa Loa (eye worm) hypothetical protein 0.0049 0.0467 0.1466
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0761 0.329

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) = 5.46 pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells ChEMBL. 23571415
IC50 (ADMET) = 5.52 pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells ChEMBL. 23571415
Inhibition (ADMET) = 12.41515527 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 20.37132086 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Ki (ADMET) = 1.65 uM Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells ChEMBL. 23571415
Ki (ADMET) = 2.64 uM Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells ChEMBL. 23571415

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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