TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 465.543 | Formula: C29H27N3O3
H donors: 1 H acceptors: 4 LogP: 4.22 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)[C@@H]1Cc2n(CCc3ccccc3)cnc2CN1C(=O)C(c1ccccc1)c1ccccc1
InChi: 1S/C29H27N3O3/c33-28(27(22-12-6-2-7-13-22)23-14-8-3-9-15-23)32-19-24-25(18-26(32)29(34)35)31(20-30-24)17-16-21-10-4-1-5-11-21/h1-15,20,26-27H,16-19H2,(H,34,35)/t26-/m0/s1
InChiKey: STKVKKUTLLYKNG-SANMLTNESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Angiotensin II receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II receptor	359 aa	336 aa	22.3 %
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Angiotensin II receptor	359 aa	351 aa	21.9 %
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	Angiotensin II receptor	359 aa	351 aa	21.9 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II receptor	359 aa	330 aa	26.7 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II receptor	359 aa	327 aa	24.2 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	386 aa	24.9 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	312 aa	19.2 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II receptor	359 aa	407 aa	19.4 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II receptor	359 aa	299 aa	25.1 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II receptor	359 aa	303 aa	22.4 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	303 aa	25.1 %
Brugia malayi	putative neuropeptide receptor NPR1	Angiotensin II receptor	359 aa	295 aa	27.5 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II receptor	359 aa	334 aa	23.7 %
Schistosoma mansoni	adenoreceptor	Angiotensin II receptor	359 aa	329 aa	24.0 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	294 aa	23.8 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II receptor	359 aa	337 aa	24.0 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II receptor	359 aa	314 aa	26.1 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Angiotensin II receptor	359 aa	346 aa	18.2 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II receptor	359 aa	314 aa	20.1 %
Brugia malayi	GnHR receptor homolog	Angiotensin II receptor	359 aa	364 aa	20.9 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II receptor	359 aa	308 aa	22.4 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II receptor	359 aa	352 aa	20.5 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	314 aa	25.8 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II receptor	359 aa	406 aa	20.0 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II receptor	359 aa	311 aa	23.5 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II receptor	359 aa	348 aa	25.9 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	395 aa	23.0 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II receptor	359 aa	316 aa	25.0 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II receptor	359 aa	316 aa	25.3 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II receptor	359 aa	348 aa	25.9 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II receptor	359 aa	303 aa	22.4 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II receptor	359 aa	356 aa	24.2 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II receptor	359 aa	335 aa	23.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.008	0.0004	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Echinococcus granulosus	tyrosine protein kinase otk	0.0097	0.0262	0.0262
Schistosoma mansoni	tyrosine kinase	0.0176	0.1471	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0262	0.0325
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	titin	0.0228	0.2259	0.2369
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0262	0.0325
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0179	0.1515	0.1515
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0179	0.1515	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.2237	0.2774
Echinococcus granulosus	Netrin receptor DCC	0.0179	0.1515	0.1515
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0275	0.2986	0.3388
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0275	0.2986	0.3703
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.008	0.0004	0.0635
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0275	0.2986	0.3132
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0179	0.1515	0.1879
Loa Loa (eye worm)	hypothetical protein	0.043	0.5344	0.6627
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	Immunoglobulin	0.043	0.534	0.5601
Giardia lamblia	Kinase, NEK	0.0079	0	0.5
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0228	0.2264	0.2375
Entamoeba histolytica	protein kinase domain containing protein	0.0081	0.0022	0.3888
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.043	0.534	0.6059
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0179	0.1515	0.1719
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0228	0.2259	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0226	0.2237	0.2774
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0179	0.1515	0.1719
Loa Loa (eye worm)	hypothetical protein	0.0546	0.7103	0.8809
Leishmania major	protein kinase, putative	0.0081	0.0022	0.0147
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0097	0.0262	0.0325
Trichomonas vaginalis	TK family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0	0.5
Echinococcus granulosus	anosmin 1	0.0179	0.1515	0.1515
Echinococcus multilocularis	usherin	0.0179	0.1515	0.1589
Echinococcus multilocularis	activin receptor type	0.0081	0.0022	0.0023
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0275	0.2986	0.2986
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0479	0.6089	0.6089
Loa Loa (eye worm)	STE/STE20/SLK protein kinase	0.0191	0.1693	0.21
Trichomonas vaginalis	STE family protein kinase	0.0079	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0081	0.0022	0.0147
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0258	0.2724	0.2857
Echinococcus multilocularis	hemicentin 1	0.0097	0.0262	0.0275
Echinococcus granulosus	Netrin receptor DCC	0.0179	0.1515	0.1515
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Schistosoma mansoni	vesicular amine transporter	0.043	0.534	0.6059
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0228	0.2264	0.2808
Echinococcus granulosus	neuroglian	0.0477	0.6062	0.6062
Giardia lamblia	Protein 21.1	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Brugia malayi	Fibronectin type III domain containing protein	0.0179	0.1515	0.1879
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0097	0.0262	0.1161
Loa Loa (eye worm)	hypothetical protein	0.043	0.534	0.6622
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0179	0.1515	0.1719
Plasmodium vivax	protein kinase, putative	0.0079	0	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0258	0.2724	0.2724
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0	0.5
Echinococcus multilocularis	Fibronectin, type III	0.0179	0.1515	0.1589
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0609	0.8064	1
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0097	0.0262	0.0325
Schistosoma mansoni	nephrin	0.0656	0.8786	0.9969
Echinococcus granulosus	lachesin	0.0097	0.0262	0.0262
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0609	0.8064	1
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Leishmania major	hypothetical protein, conserved	0.0179	0.1515	1
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	Fibronectin type III	0.0179	0.1515	0.1515
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	hypothetical protein	0.0226	0.2237	0.2538
Onchocerca volvulus		0.0179	0.1515	0.6706
Echinococcus multilocularis	Immunoglobulin	0.043	0.534	0.5601
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	tripartite motif protein trim9	0.0179	0.1515	0.1719
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0179	0.1515	0.1515
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0179	0.1515	0.1719
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0179	0.1515	0.1589
Schistosoma mansoni	titin	0.0228	0.2259	0.2563
Brugia malayi	Protein kinase domain containing protein	0.0191	0.1693	0.21
Echinococcus multilocularis	neuroglian	0.0275	0.2986	0.3132
Brugia malayi	Fibronectin type III domain containing protein	0.0179	0.1515	0.1879
Schistosoma mansoni	protein kinase	0.0081	0.0022	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0266	0.033
Brugia malayi	myotactin form B	0.0179	0.1515	0.1879
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0558	0.7298	0.905
Brugia malayi	Peroxidasin	0.0097	0.0266	0.033
Echinococcus granulosus	usherin	0.0179	0.1515	0.1515
Echinococcus granulosus	anosmin 1	0.0179	0.1515	0.1515
Echinococcus granulosus	defective proboscis extension response	0.043	0.534	0.534
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0226	0.2237	0.2774
Brugia malayi	hypothetical protein	0.0609	0.8064	1
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0179	0.1515	0.1589
Entamoeba histolytica	protein kinase, putative	0.008	0.0004	0.0635
Echinococcus multilocularis	anosmin 1	0.0179	0.1515	0.1589
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0179	0.1515	0.1879
Entamoeba histolytica	hypothetical protein	0.008	0.0004	0.0635
Brugia malayi	SPRY domain containing protein	0.0179	0.1515	0.1879
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	UNCoordinated family member	0.0179	0.1515	0.1879
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0081	0.0022	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0226	0.2237	0.2774
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0179	0.1515	0.1515
Brugia malayi	Lethal protein 805	0.0179	0.1515	0.1879
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0127	0.0722	0.0757
Schistosoma mansoni	factor for adipocyte differentiation	0.0179	0.1515	0.1719
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0081	0.0022	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	Netrin receptor DCC	0.0179	0.1515	0.1589
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0179	0.1515	0.1589
Echinococcus granulosus	anosmin 1	0.0179	0.1515	0.1515
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Brugia malayi	Protein-tyrosine phosphatase	0.0179	0.1515	0.1879
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	septate junction protein	0.0097	0.0262	0.0298
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0097	0.0262	0.0325
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0	0.5
Echinococcus multilocularis	transfer RNA-Phe	0.0226	0.2237	0.2346
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0226	0.2237	0.2237
Echinococcus granulosus	contactin	0.0275	0.2986	0.2986
Schistosoma mansoni	roundabout	0.0097	0.0262	0.0298
Trichomonas vaginalis	AGC family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0079	0	0.5
Onchocerca volvulus		0.0179	0.1515	0.6706
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0179	0.1515	0.1589
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0079	0	0.5
Brugia malayi	hypothetical protein	0.0179	0.1515	0.1879
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0081	0.0022	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	roundabout 2	0.0275	0.2986	0.2986
Echinococcus granulosus	activin receptor type	0.0081	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Schistosoma mansoni	cell adhesion molecule	0.0226	0.2237	0.2538
Echinococcus granulosus	EG95	0.0179	0.1515	0.1515
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	roundabout 2	0.0275	0.2986	0.3132
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0277	0.3008	0.3731
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0558	0.7298	0.905
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Onchocerca volvulus		0.0226	0.2237	0.9901
Loa Loa (eye worm)	projectin	0.0226	0.2237	0.2774
Echinococcus granulosus	roundabout 2	0.0275	0.2986	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Brugia malayi	protein unc-22	0.0228	0.2259	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.0097	0.0262	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Schistosoma mansoni	myosin-binding protein-related	0.0226	0.2237	0.2538
Onchocerca volvulus		0.0179	0.1515	0.6706
Echinococcus multilocularis	neuroglian	0.0477	0.6062	0.6358
Echinococcus granulosus	peroxidasin	0.0097	0.0266	0.0266
Echinococcus multilocularis	hemicentin 1	0.0097	0.0262	0.0275
Schistosoma mansoni	cell adhesion molecule	0.0275	0.2986	0.3388
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0	0.5
Echinococcus multilocularis	cell adhesion molecule	0.0179	0.1515	0.1589
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0179	0.1515	0.1879
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0179	0.1515	0.1879
Brugia malayi	Fibronectin type III domain containing protein	0.0179	0.1515	0.1879
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0479	0.6089	0.7551
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0179	0.1515	0.1879
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0275	0.2986	0.3703
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0179	0.1515	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.2237	0.2774
Loa Loa (eye worm)	hypothetical protein	0.0526	0.6811	0.8446
Loa Loa (eye worm)	hypothetical protein	0.0609	0.8064	1
Echinococcus granulosus	nephrin	0.0226	0.2237	0.2237
Loa Loa (eye worm)	TK/ROR protein kinase	0.0127	0.0722	0.0895
Schistosoma mansoni	protein kinase	0.0191	0.1693	0.1921
Brugia malayi	myotactin form A	0.0179	0.1515	0.1879
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0179	0.1515	0.1515
Loa Loa (eye worm)	hypothetical protein	0.0226	0.2237	0.2774
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0081	0.0022	0.0023
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0228	0.2264	0.2264
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0275	0.2986	0.3132
Onchocerca volvulus		0.0228	0.2259	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0179	0.1515	0.1879
Echinococcus granulosus	twitchin	0.0479	0.6084	0.6084
Schistosoma mansoni	factor for adipocyte differentiation	0.0179	0.1515	0.1719
Echinococcus granulosus	titin	0.0228	0.2259	0.2259
Schistosoma mansoni	protein kinase	0.0081	0.0022	0.0025
Onchocerca volvulus		0.0179	0.1515	0.6706
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0097	0.0262	0.0275
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0097	0.0262	0.0325
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0081	0.0022	0.0022
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0097	0.0262	0.0325
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.2237	0.2774
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	cell adhesion molecule	0.0179	0.1515	0.1515
Onchocerca volvulus		0.0179	0.1515	0.6706
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0179	0.1515	0.1515
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.0057	1
Brugia malayi	Prion-like-	0.0097	0.0262	0.0325
Echinococcus multilocularis	Netrin receptor DCC	0.0179	0.1515	0.1589
Schistosoma mansoni	hypothetical protein	0.0179	0.1515	0.1719
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0609	0.8064	1
Schistosoma mansoni	neuroglian	0.0275	0.2986	0.3388
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0079	0	0.5
Echinococcus multilocularis	lachesin	0.0097	0.0262	0.0275
Schistosoma mansoni	titin	0.0226	0.2237	0.2538
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.1515	1
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	Immunoglobulin	0.043	0.534	0.534
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0262	0.0325
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0179	0.1515	0.1589
Giardia lamblia	Kinase	0.0079	0	0.5
Loa Loa (eye worm)	lethal protein 805	0.0179	0.1515	0.1879
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0	0.5
Schistosoma mansoni	hypothetical protein	0.0179	0.1515	0.1719
Entamoeba histolytica	tyrosin kinase, putative	0.0083	0.0057	1
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0179	0.1515	0.1879
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.043	0.534	0.5601
Entamoeba histolytica	hypothetical protein	0.008	0.0004	0.0635
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0179	0.1515	1
Echinococcus multilocularis	titin	0.0179	0.1515	0.1589
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0079	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0081	0.0022	0.0147
Loa Loa (eye worm)	TK protein kinase	0.0127	0.0722	0.0895
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	hemicentin 1	0.0097	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Loa Loa (eye worm)	myotactin form A	0.0179	0.1515	0.1879
Schistosoma mansoni	titin	0.0097	0.0262	0.0298
Trypanosoma brucei	protein kinase, putative	0.0081	0.0022	0.0147
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0226	0.2237	0.2774
Schistosoma mansoni	factor for adipocyte differentiation	0.0179	0.1515	0.1719
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0179	0.1515	0.1589
Onchocerca volvulus		0.0179	0.1515	0.6706
Onchocerca volvulus		0.0179	0.1515	0.6706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0275	0.2986	0.3703
Echinococcus multilocularis	tyrosine protein kinase otk	0.0097	0.0262	0.0275
Schistosoma mansoni	protein tyrosine phosphatase	0.0179	0.1515	0.1719
Echinococcus granulosus	roundabout 2	0.0705	0.9535	0.9535
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0262	0.0325
Echinococcus granulosus	neuroglian	0.0275	0.2986	0.2986
Onchocerca volvulus	Tyrosine kinase homolog	0.0127	0.0722	0.3196
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.2237	0.2774
Loa Loa (eye worm)	CAMK protein kinase	0.0228	0.2259	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	hemicentin	0.0226	0.2237	0.2538
Onchocerca volvulus		0.0179	0.1515	0.6706
Echinococcus multilocularis	anosmin 1	0.0179	0.1515	0.1589
Onchocerca volvulus		0.0226	0.2237	0.9901
Onchocerca volvulus		0.0179	0.1515	0.6706
Echinococcus multilocularis	peroxidasin	0.0097	0.0266	0.0279
Echinococcus granulosus	titin	0.0228	0.2259	0.2259
Loa Loa (eye worm)	hypothetical protein	0.043	0.534	0.6622
Loa Loa (eye worm)	CAMK/CAMKL/NUAK protein kinase	0.058	0.7624	0.9455
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	nephrin	0.0275	0.2986	0.3388
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2986	0.3703
Schistosoma mansoni	cell adhesion molecule	0.0275	0.2986	0.3388
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0097	0.0262	0.0298
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.043	0.534	0.6059
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0262	0.0325
Schistosoma mansoni	cell adhesion molecule	0.0658	0.8813	1
Giardia lamblia	Kinase, NEK	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	ephrin receptor	0.0258	0.2724	0.3091
Schistosoma mansoni	cell adhesion molecule	0.0226	0.2237	0.2538
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0262	0.0325
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0127	0.0722	0.0895
Trichomonas vaginalis	CAMK family protein kinase	0.0079	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0097	0.0262	0.0325
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.2237	0.2774
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Onchocerca volvulus		0.0179	0.1515	0.6706
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0179	0.1515	0.1515
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2259	0.2563
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Onchocerca volvulus		0.0179	0.1515	0.6706
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0179	0.1515	0.1879
Loa Loa (eye worm)	hypothetical protein	0.0526	0.6811	0.8446
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus granulosus	G1Y162 protein	0.0179	0.1515	0.1515
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0275	0.2986	0.3132
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0275	0.2986	0.3132
Echinococcus granulosus	STE20 serine:threonine protein kinase	0.0547	0.7125	0.7125
Trichomonas vaginalis	protein kinase atn1, putative	0.0079	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1515	0.1879
Brugia malayi	Lethal protein 805	0.0179	0.1515	0.1879
Schistosoma mansoni	protein kinase	0.0081	0.0022	0.0025
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0275	0.2986	0.3703
Loa Loa (eye worm)	hypothetical protein	0.0609	0.8064	1
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	septate junction protein	0.0097	0.0262	0.0298
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.2237	0.2774
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Schistosoma mansoni	titin	0.0179	0.1515	0.1719
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0179	0.1515	0.1879
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0097	0.0262	0.0325
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Echinococcus multilocularis	STE20 serine:threonine protein kinase	0.0547	0.7125	0.7473
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0097	0.0262	0.0325
Trichomonas vaginalis	TKL family protein kinase	0.0079	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0081	0.0022	0.0147
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0228	0.2264	0.2808
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0079	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0228	0.2259	0.2802
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0127	0.0722	0.0722
Echinococcus multilocularis	anosmin 1	0.0179	0.1515	0.1589
Echinococcus multilocularis	roundabout 2	0.0275	0.2986	0.3132
Echinococcus multilocularis	roundabout 2	0.0705	0.9535	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.24 uM	Binding affinity against Angiotensin II receptor, from rat adrenal gland	ChEMBL.	1956044
IC50 (binding)	= 0.24 uM	Binding affinity against Angiotensin II receptor, from rat adrenal gland	ChEMBL.	1956044

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 183523