Detailed information for compound 1841199

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 746.795 | Formula: C38H50O15
  • H donors: 2 H acceptors: 8 LogP: 2.45 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C[C@H]1[C@@](C)(COC(=O)C)OC(=O)C[C@@H]([C@]1(C)[C@H]1[C@@H](C(=O)O)[C@H](OC(=O)[C@@H]([C@@H](CC)C)O)[C@]2([C@]3(C1=C)O[C@@H]3C[C@@H]2c1ccoc1)C)OC(=O)C
  • InChi: 1S/C38H50O15/c1-10-18(2)31(43)34(46)51-32-29(33(44)45)30(19(3)38-26(52-38)13-23(37(32,38)8)22-11-12-48-16-22)36(7)24(14-27(41)47-9)35(6,17-49-20(4)39)53-28(42)15-25(36)50-21(5)40/h11-12,16,18,23-26,29-32,43H,3,10,13-15,17H2,1-2,4-9H3,(H,44,45)/t18-,23-,24+,25+,26-,29-,30-,31-,32+,35-,36-,37+,38-/m1/s1
  • InChiKey: RCAJZZHXBIKARG-VKXSZFOESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0004 0.0018 0.0047
Onchocerca volvulus 0.0012 0.0148 0.1017
Echinococcus granulosus cpg binding protein 0.0011 0.0131 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0004 0.0018 0.0047
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0133 0.2068 0.2068
Schistosoma mansoni smad1 5 8 and 0.0005 0.0028 0.0028
Echinococcus multilocularis cpg binding protein 0.0011 0.0131 0.0131
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0004 0.001 0.001
Trypanosoma cruzi Alpha/beta hydrolase domain-containing protein 0.0004 0.002 0.0004
Trichomonas vaginalis malate dehydrogenase, putative 0.012 0.1853 0.4804
Echinococcus granulosus L lactate dehydrogenase B chain 0.0632 1 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0148 0.0384
Chlamydia trachomatis malate dehydrogenase 0.0246 0.3856 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0004 0.0018 0.0047
Schistosoma mansoni smad1 5 8 and 0.0005 0.0028 0.0028
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0004 0.0018 0.0047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0004 0.001 0.001
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Loa Loa (eye worm) Smad1 0.0005 0.0028 0.002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0035 0.0026
Schistosoma mansoni steroid hormone receptor ad4bp 0.0004 0.001 0.001
Loa Loa (eye worm) malate dehydrogenase 0.0246 0.3856 0.3851
Brugia malayi Smad1 0.0005 0.0028 0.002
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0246 0.3856 0.3818
Echinococcus multilocularis smad 0.0005 0.0028 0.0028
Mycobacterium ulcerans acetyl hydrolase MbtJ 0.0004 0.002 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0004 0.001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0011 0.0132 0.0132
Leishmania major malate dehydrogenase 0.0246 0.3856 0.3845
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0148 0.0338
Mycobacterium tuberculosis Probable esterase LipC 0.0004 0.002 0.0051
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0004 0.001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0004 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.0004 0.002 0.0011
Toxoplasma gondii lactate dehydrogenase LDH2 0.0632 1 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0246 0.3856 1
Echinococcus granulosus caspase 0.0133 0.2068 0.2068
Brugia malayi MH2 domain containing protein 0.0073 0.1111 0.1104
Trypanosoma cruzi metacaspase, putative 0.0059 0.0885 0.2258
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0133 0.2068 0.2068
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0004 0.001 0.0001
Echinococcus granulosus cytochrome P450 2K1 0.0004 0.0018 0.0018
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0004 0.0018 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.001 0.001
Echinococcus multilocularis malate dehydrogenase 0.0246 0.3856 0.3856
Trichomonas vaginalis Esterase, putative 0.0004 0.002 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.001 0.0001
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0004 0.002 0.0002
Trichomonas vaginalis malate dehydrogenase, putative 0.012 0.1853 0.4804
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0148 0.0139
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.002 0.0269 0.026
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0148 0.0148
Leishmania major cytosolic malate dehydrogenase 0.0246 0.3856 0.3845
Echinococcus granulosus lactate dehydrogenase a 0.0632 1 1
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0246 0.3856 0.3818
Trypanosoma brucei Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0004 0.002 0.0004
Echinococcus multilocularis Smad4 0.0005 0.0028 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.0007 0.0062 0.016
Echinococcus granulosus Smad4 0.0005 0.0028 0.0028
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0246 0.3856 0.3856
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0004 0.0018 0.0047
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0004 0.002 0.0004
Schistosoma mansoni cpg binding protein 0.0011 0.0121 0.0121
Echinococcus granulosus lactate dehydrogenase protein 0.0632 1 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0004 0.0018 0.0047
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0022 0.0292 0.0758
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0011 0.0132 0.0132
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0005 0.0028 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0023 0.0312 0.081
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0004 0.0018 0.0047
Leishmania major hypothetical protein, conserved 0.0004 0.002 0.0002
Plasmodium vivax malate dehydrogenase, putative 0.0632 1 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0004 0.002 0.002
Plasmodium vivax SET domain protein, putative 0.0011 0.0132 0.007
Schistosoma mansoni caspase-3 (C14 family) 0.0133 0.2068 0.2068
Echinococcus granulosus ecdysone induced protein 78C 0.0004 0.001 0.001
Trypanosoma cruzi metacaspase, putative 0.0059 0.0885 0.2258
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0004 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.0632 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.001 0.0001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0007 0.0062 0.016
Schistosoma mansoni L-lactate dehydrogenase 0.0246 0.3856 0.3856
Echinococcus multilocularis caspase 2 0.008 0.122 0.122
Toxoplasma gondii lactate dehydrogenase LDH1 0.0632 1 1
Echinococcus multilocularis caspase 3 0.0074 0.1132 0.1132
Trypanosoma brucei metacaspase 0.0059 0.0885 0.2258
Echinococcus granulosus cytosolic malate dehydrogenase 0.0246 0.3856 0.3856
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0148 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0004 0.001 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0007 0.0062 1
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0246 0.3856 0.3851
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0004 0.0018 0.0047
Mycobacterium tuberculosis Probable esterase/lipase LipF 0.0004 0.002 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.032 0.032
Echinococcus multilocularis 0.0004 0.0018 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.0004 0.001 0.001
Trypanosoma cruzi metacaspase 5, putative 0.0059 0.0885 0.2258
Trypanosoma brucei metacaspase 5, putative 0.0059 0.0885 0.2258
Onchocerca volvulus Cell death protein 3 homolog 0.008 0.122 0.8902
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0004 0.0018 0.0047
Schistosoma mansoni cpg binding protein 0.0011 0.0131 0.0131
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0009 0.0009
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0022 0.0292 0.0292
Loa Loa (eye worm) MH2 domain-containing protein 0.0073 0.1111 0.1103
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0022 0.0292 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0004 0.001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.001 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0103 0.0095
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0023 0.0312 0.0312
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0148 0.0338
Schistosoma mansoni hypothetical protein 0.0021 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Leishmania major cytochrome p450-like protein 0.001 0.0103 0.0085
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0312 0.0312
Toxoplasma gondii malate dehydrogenase MDH 0.0632 1 1
Mycobacterium tuberculosis Probable acetyl-hydrolase/esterase LipR 0.0004 0.002 0.0051
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0246 0.3856 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0059 0.0885 0.0877
Echinococcus multilocularis caspase 0.0133 0.2068 0.2068
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0004 0.0018 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0004 0.0018 0.0047
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0148 0.0338
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0011 0.0121 0.0121
Trypanosoma brucei cytochrome P450, putative 0.001 0.0103 0.0222
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0246 0.3856 1
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0103 0.0095
Leishmania major glycosomal malate dehydrogenase 0.0246 0.3856 0.3845
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Trypanosoma cruzi malate dehydrogenase, putative 0.0246 0.3856 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0023 0.0312 0.081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0004 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0004 0.001 0.0001
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0246 0.3856 0.3856
Echinococcus granulosus dnaJ subfamily B 0.0154 0.2395 0.2395
Leishmania major malate dehydrogenase, putative 0.0632 1 1
Echinococcus multilocularis lactate dehydrogenase a 0.0632 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0133 0.2068 0.2068
Onchocerca volvulus 0.0089 0.1369 1
Brugia malayi cytochrome P450 0.0004 0.0018 0.001
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0022 0.0292 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0384
Brugia malayi photoreceptor-specific nuclear receptor 0.0004 0.001 0.0001
Mycobacterium tuberculosis Probable lipase LipH 0.0004 0.002 0.0051
Schistosoma mansoni thyroid hormone receptor 0.0004 0.001 0.001
Mycobacterium leprae Possible lipase LipU 0.0004 0.002 0.0051
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0004 0.002 0.0002
Trichomonas vaginalis Esterase, putative 0.0004 0.002 0.0051
Echinococcus multilocularis caspase 8 0.0059 0.0885 0.0885
Loa Loa (eye worm) aryl-acylamidase 0.0004 0.002 0.0011
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0246 0.3856 1
Schistosoma mansoni malate dehydrogenase 0.0632 1 1
Brugia malayi Pre-SET motif family protein 0.0078 0.1197 0.119
Mycobacterium tuberculosis Probable esterase LipM 0.0004 0.002 0.0051
Echinococcus granulosus apoptotic protease activating factor 1 0.0021 0.0284 0.0284
Schistosoma mansoni smad1 5 8 and 0.0005 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0123
Mycobacterium ulcerans carboxylesterase LipQ 0.0004 0.002 0.0051
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0246 0.3856 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0148 0.0338
Brugia malayi hypothetical protein 0.0021 0.0284 0.0276
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0022 0.0292 0.0292
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0148 0.013
Schistosoma mansoni retinoic acid receptor RXR 0.0004 0.001 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0009 0.0009
Schistosoma mansoni malate dehydrogenase 0.0246 0.3856 0.3856
Schistosoma mansoni RAR-like nuclear receptor 0.0004 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0885 0.0877
Schistosoma mansoni thyroid hormone receptor 0.0004 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0284 0.0276
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0148 0.0384
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0059 0.0885 0.0868
Trypanosoma brucei malate dehydrogenase-related 0.0246 0.3856 1
Plasmodium falciparum L-lactate dehydrogenase 0.0632 1 1
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0515 0.0507
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0148 0.0338
Giardia lamblia Malate dehydrogenase 0.0246 0.3856 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0004 0.001 0.001
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0004 0.0018 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0384
Toxoplasma gondii exonuclease III APE 0.0007 0.0062 0.0044
Brugia malayi Pre-SET motif family protein 0.0011 0.0132 0.0123
Schistosoma mansoni nuclear hormone receptor 0.0004 0.001 0.001
Plasmodium falciparum metacaspase-like protein 0.0059 0.0885 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0885 0.2294
Onchocerca volvulus 0.0011 0.0132 0.0896
Schistosoma mansoni coup transcription factor 0.0004 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0007 0.0062 0.0113
Echinococcus granulosus L lactate dehydrogenase 0.0386 0.6093 0.6093
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0885 0.0828
Loa Loa (eye worm) hypothetical protein 0.008 0.122 0.1212
Schistosoma mansoni ap endonuclease 0.0007 0.0062 0.0062
Echinococcus granulosus TGF beta signal transducer SmadC 0.0005 0.0028 0.0028
Loa Loa (eye worm) transcription factor SMAD2 0.0073 0.1111 0.1103
Brugia malayi STAT protein, DNA binding domain containing protein 0.008 0.123 0.1222
Loa Loa (eye worm) MH1 domain-containing protein 0.0005 0.0028 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0148 0.0384
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0004 0.0018 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0011 0.0132 0.0132
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0148 0.0148
Echinococcus granulosus mothers against decapentaplegic 5 0.0005 0.0028 0.0028
Leishmania major protein kinase, putative 0.0012 0.0148 0.013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0004 0.001 0.001
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0059 0.0885 0.0885
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0004 0.0018 0.0047
Mycobacterium ulcerans lipase LipU 0.0004 0.002 0.0051
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Trypanosoma brucei metacaspase MCA3 0.0059 0.0885 0.2258
Brugia malayi MH1 domain containing protein 0.0005 0.0028 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0007 0.0062 0.0113
Brugia malayi nuclear receptor NHR-88 0.0004 0.001 0.0001
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.2315 0.2308
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0004 0.0018 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0011 0.0132 0.0132
Echinococcus granulosus malate dehydrogenase 0.0246 0.3856 0.3856
Echinococcus multilocularis lactate dehydrogenase a 0.0632 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0022 0.0292 0.0758
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0004 0.0018 0.0047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0004 0.001 0.001
Trypanosoma brucei metacaspase MCA2 0.0059 0.0885 0.2258
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0007 0.0062 0.0062
Trichomonas vaginalis ap endonuclease, putative 0.0007 0.0062 0.016
Plasmodium vivax lactate dehydrogenase 0.0632 1 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0004 0.0018 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0004 0.0018 0.0047
Trypanosoma brucei glycosomal malate dehydrogenase 0.0246 0.3856 1
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0148 0.0384
Onchocerca volvulus 0.0036 0.0515 0.3717
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0312 0.0312
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.001 0.001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0011 0.0132 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0004 0.001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0004 0.001 0.0001
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0004 0.002 0.002
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0632 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0004 0.0018 0.0047
Leishmania major metacaspase, putative 0.0059 0.0885 0.0868
Loa Loa (eye worm) CYP4Cod1 0.001 0.0103 0.0095
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0148 0.0148
Loa Loa (eye worm) cytochrome P450 family protein 0.0004 0.0018 0.0009
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0004 0.0018 0.0047
Loa Loa (eye worm) STAT protein 0.008 0.123 0.1222
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0246 0.3856 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0004 0.001 0.0001
Schistosoma mansoni malate dehydrogenase 0.0246 0.3856 0.3856
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0004 0.001 0.001
Treponema pallidum N-acetylphosphinothricin-tripetide-deacetylase 0.0004 0.002 0.3199
Brugia malayi Steroid receptor seven-up type 2 0.0004 0.001 0.0001
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0004 0.0018 0.0047
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0023 0.0312 0.0295
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.001 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0004 0.001 0.001
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Echinococcus multilocularis hormone sensitive lipase 0.0004 0.002 0.002
Toxoplasma gondii aldehyde dehydrogenase 0.0023 0.0312 0.0295
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0023 0.0312 0.081
Brugia malayi MH2 domain containing protein 0.0005 0.0028 0.002
Schistosoma mansoni hypothetical protein 0.0051 0.0757 0.0757
Brugia malayi steroid hormone receptor 0.0004 0.001 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.0004 0.001 0.0001
Schistosoma mansoni single-minded 0.0048 0.0714 0.0714
Loa Loa (eye worm) cytochrome P450 0.0004 0.0018 0.0009
Echinococcus granulosus hormone sensitive lipase 0.0004 0.002 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0004 0.001 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Trichomonas vaginalis set domain proteins, putative 0.0089 0.1369 0.3551
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0148 0.0384
Mycobacterium ulcerans esterase LipO 0.0004 0.002 0.0051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0011 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0885 0.2294
Mycobacterium ulcerans esterase LipW 0.0004 0.002 0.0051
Schistosoma mansoni caspase-7 (C14 family) 0.008 0.122 0.122
Leishmania major malate dehydrogenase, putative 0.0246 0.3856 0.3845
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0246 0.3856 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0885 0.2294
Echinococcus multilocularis L lactate dehydrogenase 0.0386 0.6093 0.6093
Brugia malayi hypothetical protein 0.0161 0.2514 0.2507
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Echinococcus granulosus smad 0.0005 0.0028 0.0028
Schistosoma mansoni cytochrome P450 0.0004 0.0018 0.0018
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0632 1 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0246 0.3856 1
Schistosoma mansoni malate dehydrogenase 0.0246 0.3856 0.3856
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0004 0.001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0005 0.0028 0.002
Trypanosoma brucei cytosolic malate dehydrogenase 0.0246 0.3856 1
Mycobacterium ulcerans malate dehydrogenase 0.0246 0.3856 1
Mycobacterium ulcerans lipase LipU 0.0004 0.002 0.0051
Entamoeba histolytica malate dehydrogenase, putative 0.0246 0.3856 0.3818
Mycobacterium ulcerans esterase/lipase 0.0004 0.002 0.0051
Mycobacterium ulcerans lipase LipI 0.0004 0.002 0.0051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0007 0.0062 0.0062
Brugia malayi ecdysteroid receptor 0.0004 0.001 0.0001
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0059 0.0885 0.0868
Mycobacterium ulcerans esterase LipC 0.0004 0.002 0.0051
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0022 0.0292 0.0275
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Schistosoma mansoni hypothetical protein 0.0154 0.2395 0.2395
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.001 0.0103 0.0268
Onchocerca volvulus 0.0011 0.0121 0.0819
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0004 0.0018 0.0047
Mycobacterium tuberculosis Possible lipase LipU 0.0004 0.002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0161 0.2514 0.2507
Echinococcus granulosus malate dehydrogenase 0.0246 0.3856 0.3856
Echinococcus multilocularis dnaJ subfamily B 0.0154 0.2395 0.2395
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0004 0.0018 0.0047
Mycobacterium leprae putative cytochrome p450 0.0004 0.0018 0.0047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0004 0.002 0.002
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0004 0.0018 0.0047
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0148 0.0148
Mycobacterium tuberculosis Putative acetyl hydrolase MbtJ 0.0004 0.002 0.0051
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0059 0.0885 0.0868
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0004 0.0018 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0011 0.0121 0.0112
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0004 0.0018 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0011 0.0132 0.0132
Echinococcus multilocularis apoptotic protease activating factor 1 0.0021 0.0284 0.0284
Mycobacterium ulcerans hypothetical protein 0.0004 0.002 0.0051
Echinococcus granulosus single minded 2 0.0036 0.0515 0.0515
Onchocerca volvulus 0.0021 0.0284 0.202
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0004 0.001 0.001
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0246 0.3856 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0023 0.0312 0.081
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0004 0.001 0.0001
Mycobacterium tuberculosis Probable lipase/esterase LipN 0.0004 0.002 0.0051
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0103 0.0222
Brugia malayi Cytochrome P450 family protein 0.0004 0.0018 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0021 0.0281 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0004 0.001 0.0001
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0515 0.1336
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0007 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0148 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0004 0.0018 0.0047
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0103 0.0222
Echinococcus granulosus caspase 2 0.008 0.122 0.122
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0004 0.0018 0.0047
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0004 0.0018 0.0047
Trypanosoma cruzi metacaspase 5, putative 0.0059 0.0885 0.2258
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0007 0.0062 0.0044
Trypanosoma brucei Metacaspase-4 0.0059 0.0885 0.2258
Mycobacterium ulcerans membrane-bound esterase LipM 0.0004 0.002 0.0051
Plasmodium falciparum malate dehydrogenase 0.0632 1 1
Brugia malayi PAS domain containing protein 0.0048 0.0714 0.0706
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0007 0.0062 0.016
Mycobacterium leprae Possible regulatory protein 0.0012 0.0148 0.0384
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0246 0.3856 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0004 0.001 0.001
Brugia malayi nuclear hormone receptor 0.0004 0.001 0.0001
Plasmodium falciparum metacaspase 1 0.0059 0.0885 0.0828
Trypanosoma cruzi metacaspase, putative 0.0059 0.0885 0.2258
Leishmania major mitochondrial malate dehydrogenase 0.0246 0.3856 0.3845
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0004 0.001 0.0001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0005 0.0028 0.0028
Schistosoma mansoni Smad4 0.0005 0.0028 0.0028
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Brugia malayi MH2 domain containing protein 0.0005 0.0028 0.002
Brugia malayi Cytochrome P450 family protein 0.001 0.0103 0.0095
Echinococcus multilocularis malate dehydrogenase 0.0246 0.3856 0.3856
Trypanosoma cruzi serine peptidase, Clan SC, Family S9D 0.0004 0.002 0.0004
Echinococcus granulosus FTZ F1 alpha 0.0004 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Trichomonas vaginalis Esterase, putative 0.0004 0.002 0.0051
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0246 0.3856 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0885 0.2294
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0007 0.0062 0.0053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.001 0.0001
Onchocerca volvulus 0.0004 0.002 0.0074
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0007 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0515 0.0515
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0004 0.002 0.002
Leishmania major protein kinase, putative 0.0012 0.0148 0.013
Brugia malayi hypoxia-induced factor 1 0.0149 0.2315 0.2309
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0004 0.001 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0004 0.001 0.001
Trypanosoma cruzi metacaspase, putative 0.0059 0.0885 0.2258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0011 0.0132 0.0132
Echinococcus granulosus caspase 8 0.0059 0.0885 0.0885
Schistosoma mansoni ap endonuclease 0.0007 0.0062 0.0062
Schistosoma mansoni smad 0.0005 0.0028 0.0028
Mycobacterium tuberculosis Probable non lipolytic carboxylesterase NlhH 0.0004 0.002 0.0051
Mycobacterium tuberculosis Probable carboxylesterase LipQ 0.0004 0.002 0.0051
Plasmodium falciparum lactate dehydrogenase, putative 0.0246 0.3856 0.3818
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0148 0.0384
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0148 0.0338
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0004 0.0018 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0004 0.001 0.0001
Brugia malayi CXXC zinc finger family protein 0.0011 0.0121 0.0113
Echinococcus multilocularis lactate dehydrogenase protein 0.0632 1 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0004 0.0018 0.0047
Schistosoma mansoni cpg binding protein 0.0011 0.0131 0.0131
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0004 0.0018 0.0047
Entamoeba histolytica malate dehydrogenase, putative 0.0632 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.002 0.0051
Plasmodium vivax metacaspase 1, putative 0.0059 0.0885 0.0828
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0004 0.001 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0004 0.001 0.001
Echinococcus multilocularis lactate dehydrogenase a 0.0632 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0885 0.2294
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0004 0.002 0.0004
Schistosoma mansoni hypothetical protein 0.0004 0.0018 0.0018
Loa Loa (eye worm) ammd protein 0.0004 0.002 0.0011
Brugia malayi MH1 domain containing protein 0.0005 0.0028 0.002
Trypanosoma brucei RNA helicase, putative 0.0051 0.0757 0.1924
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0004 0.001 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0059 0.0885 0.2294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.001 0.001
Brugia malayi Cytochrome P450 family protein 0.0004 0.0018 0.001
Trichomonas vaginalis malate dehydrogenase, putative 0.0246 0.3856 1
Brugia malayi aryl-acylamidase 0.0004 0.002 0.0011
Mycobacterium ulcerans lipase LipH 0.0004 0.002 0.0051
Echinococcus granulosus cytosolic malate dehydrogenase 0.0246 0.3856 0.3856
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0246 0.3856 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0023 0.0312 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0885 0.2294
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0148 0.0384
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0148 0.0384
Echinococcus granulosus caspase 3 0.0074 0.1132 0.1132
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0078 0.1197 0.1189
Echinococcus multilocularis mothers against decapentaplegic 5 0.0005 0.0028 0.0028
Schistosoma mansoni L-lactate dehydrogenase 0.0632 1 1
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0246 0.3856 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.001 0.0001
Brugia malayi Cell death protein 3 precursor 0.008 0.122 0.1213
Mycobacterium ulcerans lipase/esterase LipN 0.0004 0.002 0.0051
Echinococcus granulosus lactate dehydrogenase a 0.0632 1 1
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0246 0.3856 0.3851
Mycobacterium tuberculosis Possible esterase LipW 0.0004 0.002 0.0051
Brugia malayi Cytochrome P450 family protein 0.001 0.0103 0.0095
Mycobacterium leprae Conserved hypothetical protein 0.0004 0.0018 0.0047
Leishmania major ecotin, putative 0.0004 0.002 0.0002
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0004 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.0004 0.001 0.0001
Mycobacterium tuberculosis Probable esterase LipO 0.0004 0.002 0.0051
Loa Loa (eye worm) malate dehydrogenase 0.0246 0.3856 0.3851
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0004 0.0018 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0004 0.0018 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0004 0.0018 0.0047
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0004 0.0018 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0007 0.0062 0.0053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0022 0.0292 0.0758
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0714 0.0714

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.