Detailed information for compound 1876493

Basic information

Technical information
  • TDR Targets ID: 1876493
  • Name: methyl (E,5R,6S,7E)-7-[2-[(2R,5S,6R)-5-acetyl oxy-6-(acetyloxymethyl)-5,6-dihydro-2H-pyran- 2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl )sulfonylamino]hept-3-enoate
  • MW: 594.674 | Formula: C28H38N2O10S
  • H donors: 1 H acceptors: 5 LogP: 2.85 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C/C=C/[C@H]([C@H](NS(=O)(=O)c1ccc(cc1)C)/C=N/OCC[C@@H]1C=C[C@@H]([C@H](O1)COC(=O)C)OC(=O)C)C
  • InChi: 1S/C28H38N2O10S/c1-19-9-12-24(13-10-19)41(34,35)30-25(20(2)7-6-8-28(33)36-5)17-29-38-16-15-23-11-14-26(39-22(4)32)27(40-23)18-37-21(3)31/h6-7,9-14,17,20,23,25-27,30H,8,15-16,18H2,1-5H3/b7-6+,29-17+/t20-,23+,25-,26+,27-/m1/s1
  • InChiKey: WTZHDRHPQXYAKQ-MLKPLNMJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (E,5R,6S)-7-[2-[(2R,5S,6R)-5-acetyloxy-6-(acetyloxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoate
  • methyl (5R,6S)-7-[2-[(2R,5S,6R)-5-acetyloxy-6-(acetyloxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoate
  • methyl (E,5R,6S,7E)-7-[2-[(2R,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoate
  • methyl (E,5R,6S)-7-[2-[(2R,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoate
  • methyl (5R,6S)-7-[2-[(2R,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoate
  • (5R,6S)-7-[2-[(2R,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoic acid methyl ester
  • (E,5R,6S,7E)-7-[2-[(2R,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoic acid methyl ester
  • (E,5R,6S)-7-[2-[(2R,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]-5-methyl-6-[(4-methylphenyl)sulfonylamino]hept-3-enoic acid methyl ester
  • MLS000438687
  • SMR000113090
  • CMLD2_000743
  • CMLDBU00002185

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.1308
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Entamoeba histolytica protein kinase, putative 0.0194 0.0978 0.7566
Echinococcus granulosus protein kinase shaggy 0.0249 0.129 0.4048
Schistosoma mansoni cell adhesion molecule 0.0036 0.0084 0.0233
Giardia lamblia Kinase, CMGC GSK 0.0249 0.129 0.3578
Brugia malayi cyclin-dependent kinase 9 0.006 0.0218 0.0218
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0194 0.0978 0.7566
Plasmodium vivax serine/threonine kinase-1, putative 0.0136 0.0648 0.1789
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0027 0.0034 0.0034
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0036 0.0084 0.0263
Toxoplasma gondii preprocathepsin c precursor, putative 0.0657 0.3596 1
Brugia malayi putative serine/threonine kinase SADA gamma 0.0037 0.0089 0.0089
Onchocerca volvulus Tyrosine kinase homolog 0.0421 0.226 0.7089
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0205 0.0915
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0095 0.0417 0.3199
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0546 0.2968 0.2968
Entamoeba histolytica protein kinase, putative 0.0029 0.0044 0.0293
Trypanosoma brucei aurora B kinase 0.0177 0.0883 0.6829
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0249 0.129 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0123 0.0123
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0027 0.0034 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0693 0.1927
Brugia malayi hypothetical protein 0.0026 0.0028 0.0028
Echinococcus granulosus epidermal growth factor receptor 0.0243 0.1253 0.3929
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Onchocerca volvulus 0.0032 0.006 0.0189
Echinococcus multilocularis sodium and chloride dependent glycine 0.0163 0.0805 0.1747
Plasmodium falciparum protein kinase 5 0.0057 0.0205 0.0555
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0089 0.0383 0.0383
Loa Loa (eye worm) AGC/PKA protein kinase 0.0095 0.0417 0.0417
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0247 0.1278 0.2776
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0009 0.0009
Echinococcus multilocularis casein kinase I delta 0.0052 0.0176 0.0383
Toxoplasma gondii AGC kinase 0.0095 0.0417 0.1138
Brugia malayi Protein kinase domain containing protein 0.0194 0.0978 0.0978
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0009 0.0008
Echinococcus multilocularis rho associated protein kinase 0.0585 0.3188 0.6922
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0194 0.0978 0.7566
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Entamoeba histolytica protein kinase domain containing protein 0.0249 0.129 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0032 0.006 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0177 0.0883 0.277
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0249 0.129 0.3573
Schistosoma mansoni protein kinase 0.0052 0.0176 0.0491
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0095 0.0417 0.3199
Onchocerca volvulus 0.0026 0.0028 0.0089
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Echinococcus granulosus casein kinase I alpha 0.0052 0.0176 0.0553
Schistosoma mansoni protein kinase 0.0182 0.0912 0.2535
Brugia malayi Protein kinase domain containing protein 0.0022 0.0006 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0009 0.0022
Onchocerca volvulus 0.0026 0.0028 0.0089
Trypanosoma brucei protein kinase, putative 0.0026 0.0026 0.0157
Plasmodium falciparum protein serine/threonine kinase-1 0.0136 0.0648 0.1789
Schistosoma mansoni tyrosine kinase 0.0231 0.1187 0.3302
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.1278 0.3555
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0095 0.0417 0.3199
Brugia malayi serine/threonine-protein kinase PAK 7 0.0546 0.2968 0.2968
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0131 0.062 0.062
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0036 0.0086 0.0086
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0092 0.0399 0.0399
Loa Loa (eye worm) TK/INSR protein kinase 0.0148 0.0717 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0205 0.0571
Brugia malayi Cell division protein kinase 2 0.0022 0.0006 0.0006
Onchocerca volvulus 0.0032 0.0059 0.0185
Leishmania major protein kinase, putative 0.0026 0.0026 0.0157
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0657 0.3596 1
Schistosoma mansoni protein kinase 0.0089 0.0383 0.1066
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0034 0.0095
Brugia malayi P21-Rho-binding domain containing protein 0.0045 0.0137 0.0137
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0026 0.0157
Plasmodium vivax glycogen synthase kinase 3, putative 0.0249 0.129 0.3578
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0205 0.0915
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0205 0.1552
Loa Loa (eye worm) hypothetical protein 0.018 0.0897 0.0897
Echinococcus multilocularis sodium and chloride dependent glycine 0.0163 0.0805 0.1747
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0648 0.2946
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0034 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0249 0.129 0.3577
Echinococcus multilocularis cyclin dependent kinase 19 0.0146 0.0708 0.1537
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0073 0.0293 0.0637
Schistosoma mansoni serine/threonine protein kinase 0.0478 0.2581 0.7177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0089 0.0383 0.2939
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0134 0.0638 0.0638
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.006 0.0189
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0205 0.0915
Echinococcus granulosus Immunoglobulin 0.0027 0.0034 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0417 0.3199
Trichomonas vaginalis CMGC family protein kinase 0.0249 0.129 0.5892
Toxoplasma gondii aurora kinase 0.0177 0.0883 0.2438
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0249 0.129 0.3577
Onchocerca volvulus 0.0249 0.129 0.4048
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0026 0.0026 0.0048
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0032 0.006 0.5
Plasmodium vivax amine transporter, putative 0.0032 0.006 0.0151
Brugia malayi casein kinase I 0.0052 0.0176 0.0176
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0136 0.0648 0.5
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0045 0.0134 0.0358
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus tyrosine protein kinase Blk 0.0026 0.0028 0.0089
Echinococcus granulosus dual specificity 0.0194 0.0978 0.3068
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Loa Loa (eye worm) hypothetical protein 0.028 0.1461 0.1461
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0249 0.129 0.129
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Entamoeba histolytica p21-activated kinase 0.006 0.0218 0.1651
Trichomonas vaginalis AGC family protein kinase 0.0095 0.0417 0.1885
Echinococcus multilocularis epidermal growth factor receptor 0.0243 0.1253 0.272
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0177 0.0883 0.6829
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0205 0.0205
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0086 0.037
Echinococcus granulosus PAK box P21 Rho binding 0.0045 0.0137 0.0431
Leishmania major protein kinase A catalytic subunit 0.0095 0.0417 0.3199
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0089 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.018 0.0897 0.0897
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0045 0.0137 0.0382
Schistosoma mansoni tyrosine kinase 0.0243 0.1253 0.3483
Trichomonas vaginalis STE family protein kinase 0.0089 0.0383 0.1731
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0034 0.0034
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0073 0.0293 0.0293
Loa Loa (eye worm) solute carrier family 6 member 4 0.0032 0.006 0.006
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0205 0.1552
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0638 0.1776
Echinococcus granulosus epidermal growth factor receptor 0.0444 0.239 0.7498
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0095 0.0417 0.3199
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0203 0.0564
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Schistosoma mansoni tyrosine kinase 0.0231 0.1187 0.3302
Echinococcus multilocularis tyrosine protein kinase Srms 0.0026 0.0028 0.0062
Schistosoma mansoni vesicular amine transporter 0.0027 0.0034 0.0094
Giardia lamblia Macrophage migration inhibitory factor 0.0036 0.0086 0.0224
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0249 0.129 0.4048
Brugia malayi SH2 domain containing protein 0.0026 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0148 0.0717 0.1995
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.1308
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.006 0.0167
Plasmodium falciparum serine/threonine protein kinase KIN 0.0037 0.0089 0.0233
Schistosoma mansoni protein kinase 0.006 0.0218 0.0606
Echinococcus granulosus dual specificity protein kinase clk2 0.0136 0.0648 0.2033
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.006 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0148 0.0717 0.1557
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0177 0.0883 0.1918
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Echinococcus multilocularis cyclin dependent kinase 5 0.0057 0.0205 0.0446
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0037 0.0089 0.0089
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Schistosoma mansoni tyrosine kinase 0.0243 0.1253 0.3483
Echinococcus granulosus activin receptor type 0.0026 0.0026 0.0082
Entamoeba histolytica hypothetical protein 0.0194 0.0978 0.7566
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0032 0.006 0.0189
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0134 0.0638 0.0638
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Leishmania major protein kinase A catalytic subunit isoform 2 0.0095 0.0417 0.3199
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0194 0.0978 0.0978
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0026 0.0028 0.0089
Onchocerca volvulus 0.0038 0.0096 0.0301
Brugia malayi Protein kinase domain containing protein 0.0146 0.0708 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0137 0.0604
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0146 0.0708 0.0708
Echinococcus multilocularis neuroglian 0.0034 0.0073 0.0158
Brugia malayi WH1 domain containing protein 0.0045 0.0137 0.0137
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0057 0.0205 0.1552
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0037 0.0089 0.065
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Brugia malayi intracellular kinase 0.0249 0.129 0.129
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0045 0.0137 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0478 0.2581 0.2581
Schistosoma mansoni tyrosine kinase 0.0231 0.1187 0.3302
Entamoeba histolytica protein kinase, putative 0.0177 0.0883 0.6829
Onchocerca volvulus 0.0585 0.3188 1
Echinococcus granulosus casein kinase I alpha 0.0052 0.0176 0.0553
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0134 0.0638 0.2003
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0036 0.0086 0.0086
Onchocerca volvulus 0.0032 0.006 0.0189
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0036 0.0086 0.0224
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Onchocerca volvulus 0.0026 0.0028 0.0089
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0131 0.062 0.062
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.006 0.0167
Schistosoma mansoni serine/threonine kinase 0.0022 0.0006 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0883 0.2456
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0205 0.0555
Echinococcus granulosus serotonin transporter 0.0032 0.006 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0009 0.0022
Echinococcus granulosus defective proboscis extension response 0.0027 0.0034 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0417 0.1159
Treponema pallidum sodium- and chloride- dependent transporter 0.0032 0.006 1
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.006 0.0218 0.0473
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Echinococcus multilocularis tyrosine protein kinase Blk 0.0026 0.0028 0.0062
Brugia malayi Protein kinase domain containing protein 0.0057 0.0205 0.0205
Brugia malayi casein kinase 1, delta 0.0052 0.0176 0.0176
Loa Loa (eye worm) haspin protein kinase 0.0022 0.0006 0.0006
Echinococcus granulosus sodium and chloride dependent glycine 0.0163 0.0805 0.2524
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0249 0.129 0.129
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0095 0.0417 0.3199
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0247 0.1278 0.1278
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0037 0.0089 0.0194
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0037 0.0089 0.065
Entamoeba histolytica protein kinase , putative 0.0177 0.0883 0.6829
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0109 0.0341
Echinococcus granulosus cyclin dependent kinase 0.0057 0.0205 0.0644
Schistosoma mansoni sodium/chloride dependent transporter 0.0178 0.0885 0.2461
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0009 0.5
Echinococcus multilocularis casein kinase i 0.0052 0.0176 0.0383
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0657 0.3596 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0009 0.0013
Entamoeba histolytica hypothetical protein 0.0045 0.0137 0.1024
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0038 0.0096 0.0701
Entamoeba histolytica cell division protein kinase 2, putative 0.0065 0.025 0.1903
Brugia malayi hypothetical protein 0.0027 0.0034 0.0034
Echinococcus granulosus beta-adrenergic receptor kinase 0.0027 0.0034 0.0107
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0009 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0059 0.0059
Trypanosoma brucei cdc2-related kinase 1 0.0057 0.0205 0.1552
Toxoplasma gondii cathepsin CPC2 0.0249 0.129 0.3572
Schistosoma mansoni tyrosine kinase 0.0444 0.239 0.6647
Echinococcus granulosus c-Jun N-terminal kinases 0.0247 0.1278 0.401
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0194 0.0978 0.7566
Leishmania major macrophage migration inhibitory factor-like protein 0.0036 0.0086 0.0627
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0382
Brugia malayi secreted modular calcium-binding protein 1 0.0032 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0028
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.006 0.0167
Echinococcus multilocularis roundabout 2 0.0043 0.0123 0.0267
Entamoeba histolytica casein kinase 1, putative 0.0052 0.0176 0.1327
Echinococcus granulosus cyclin dependent kinase 9 0.0068 0.0263 0.0825
Plasmodium vivax hypothetical protein, conserved 0.0032 0.006 0.0151
Leishmania major protein kinase A catalytic subunit isoform 1 0.0095 0.0417 0.3199
Giardia lamblia Aurora kinase 0.0177 0.0883 0.2444
Brugia malayi hypothetical protein 0.0023 0.0009 0.0009
Plasmodium falciparum glycogen synthase kinase 3 0.0249 0.129 0.3578
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0095 0.0417 0.0417
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0648 0.1803
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0095 0.0417 0.1145
Loa Loa (eye worm) AUR protein kinase 0.0177 0.0883 0.0883
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0089 0.0383 0.2939
Echinococcus granulosus serine:threonine protein kinase NLK 0.0022 0.0006 0.0018
Echinococcus multilocularis epidermal growth factor receptor 0.0444 0.239 0.519
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus multilocularis aurora kinase A 0.0177 0.0883 0.1918
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0478 0.2581 0.8095
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Onchocerca volvulus 0.0402 0.2155 0.6762
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0026 0.0028 0.0062
Giardia lamblia Kinase, STE STE20 0.006 0.0218 0.0591
Onchocerca volvulus 0.0032 0.0059 0.0185
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0057 0.0205 0.1552
Plasmodium falciparum macrophage migration inhibitory factor 0.0036 0.0086 0.0224
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0136 0.0648 0.5
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0136 0.0648 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Schistosoma mansoni nephrin 0.0034 0.0073 0.0203
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.0978 0.272
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0024
Echinococcus granulosus casein kinase I delta 0.0052 0.0176 0.0553
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0205 0.1552
Toxoplasma gondii hypothetical protein 0.0032 0.006 0.0143
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0009 0.0019
Entamoeba histolytica protein kinase, putative 0.0194 0.0978 0.7566
Entamoeba histolytica protein kinase, putative 0.0249 0.129 1
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0131 0.062 0.1944
Brugia malayi Protein kinase domain containing protein 0.0478 0.2581 0.2581
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0052 0.0176 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0218 0.0606
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0022 0.0006 0.0006
Loa Loa (eye worm) TK/ALK protein kinase 0.0291 0.1527 0.1527
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0177 0.0883 0.2444
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0131 0.062 0.062
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0026 0.0028 0.0062
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0657 0.3596 1
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Schistosoma mansoni sodium/chloride dependent transporter 0.0163 0.0805 0.2238
Echinococcus multilocularis cyclin dependent kinase 9 0.006 0.0218 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0478 0.2581 0.2581
Echinococcus multilocularis serotonin transporter 0.0032 0.006 0.0131
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0095 0.0417 0.3199
Brugia malayi serine/threonine kinase 12 0.0177 0.0883 0.0883
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0417 0.3199
Onchocerca volvulus 0.0571 0.3107 0.9748
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0032 0.006 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0026 0.0026 0.0157
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0089 0.0383 0.2939
Echinococcus multilocularis casein kinase I alpha 0.0052 0.0176 0.0383
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.006 0.0218 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0408 0.2186 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus cyclin dependent kinase 19 0.0146 0.0708 0.222
Echinococcus multilocularis activin receptor type 0.0026 0.0026 0.0057
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0205 0.0446
Brugia malayi Protein kinase domain 0.006 0.0218 0.0218
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0032 0.006 0.0131
Echinococcus granulosus aurora kinase A 0.0177 0.0883 0.277
Schistosoma mansoni protein kinase 0.0045 0.0137 0.0382
Schistosoma mansoni tyrosine kinase 0.0057 0.0203 0.0564
Brugia malayi Fibronectin type III domain containing protein 0.0027 0.0034 0.0034
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.1308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0084
Schistosoma mansoni protein kinase 0.0177 0.0883 0.2456
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Trichomonas vaginalis STE family protein kinase 0.0089 0.0383 0.1731
Entamoeba histolytica hypothetical protein 0.0045 0.0137 0.1024
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0136 0.0648 0.1783
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0478 0.2581 0.5603
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0205 0.0446
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0136 0.0648 0.5
Echinococcus multilocularis 0.0135 0.0641 0.1393
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.006 0.0218 0.0684
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0057 0.0205 0.0205
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0045 0.0137 0.0431
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0657 0.3596 1
Plasmodium falciparum casein kinase 1 0.0052 0.0176 0.0475
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0009 0.5
Brugia malayi protein-tyrosine kinase 0.0026 0.0028 0.0028
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0243 0.1253 0.3929
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Brugia malayi Tyrosine-protein kinase abl-1 0.0026 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0026 0.0028 0.0062
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Entamoeba histolytica casein kinase, putative 0.0052 0.0176 0.1327
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0028 0.0062
Loa Loa (eye worm) TK/KIN16 protein kinase 0.045 0.2424 0.2424
Schistosoma mansoni tyrosine kinase 0.0148 0.0717 0.1995
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0009 0.0022
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0037 0.0089 0.065
Echinococcus multilocularis tyrosine protein kinase shark 0.0026 0.0028 0.0062
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0249 0.129 0.3577
Brugia malayi hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus roundabout 2 0.0043 0.0123 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0081 0.0336 0.0731
Echinococcus multilocularis c src tyrosine kinase 0.0026 0.0028 0.0062
Plasmodium falciparum transporter, putative 0.0032 0.006 0.0151
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.006 0.0218 0.0473
Echinococcus granulosus dual specificity mitogen activated protein 0.0089 0.0383 0.1203
Loa Loa (eye worm) hypothetical protein 0.0045 0.0137 0.0137
Echinococcus multilocularis protein kinase shaggy 0.0249 0.129 0.2802
Echinococcus granulosus cyclin dependent kinase 7 0.0092 0.0399 0.1253
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0134 0.0638 0.1386
Leishmania major protein kinase, putative 0.0136 0.0648 0.5
Echinococcus multilocularis 0.0122 0.0568 0.1233
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0052 0.0176 0.0176
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0052 0.0176 0.0176
Brugia malayi SRC-1 0.0026 0.0028 0.0028
Trichomonas vaginalis STE family protein kinase 0.0089 0.0383 0.1731
Giardia lamblia Kinase, CMGC CLK 0.0136 0.0648 0.1789
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Giardia lamblia Kinase, CK1 Casein kinase 0.0052 0.0176 0.0475
Brugia malayi cell division control protein 2 homolog 0.0057 0.0205 0.0205
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0022 0.0006 0.0013
Onchocerca volvulus 0.0026 0.0028 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Toxoplasma gondii cathepsin CPC1 0.0657 0.3596 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0657 0.3596 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0399 0.111
Echinococcus granulosus sodium and chloride dependent glycine 0.0163 0.0805 0.2524
Loa Loa (eye worm) hypothetical protein 0.0043 0.0125 0.0125
Trichomonas vaginalis CMGC family protein kinase 0.0249 0.129 0.5892
Echinococcus multilocularis insulin receptor 0.0148 0.0717 0.1557
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0022 0.0006 0.0006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0026 0.0028 0.0062
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0024
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Echinococcus granulosus cyclin dependent kinase 1 0.0057 0.0205 0.0644
Entamoeba histolytica protein kinase, putative 0.0177 0.0883 0.6829
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0089 0.0249
Toxoplasma gondii AGC kinase 0.0095 0.0417 0.1138
Trypanosoma cruzi aurora B kinase, putative 0.0177 0.0883 0.6829
Loa Loa (eye worm) hypothetical protein 0.0163 0.0805 0.0805
Schistosoma mansoni protein kinase 0.006 0.0218 0.0606
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0382
Echinococcus multilocularis Immunoglobulin 0.0027 0.0034 0.0073
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0177 0.0883 0.6829
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0032 0.006 0.006
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.006 0.0167
Loa Loa (eye worm) TK/EGFR protein kinase 0.0444 0.239 0.239
Echinococcus granulosus rho-associated protein kinase 1 0.0585 0.3188 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0194 0.0978 0.7566
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0648 0.1803
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Loa Loa (eye worm) hypothetical protein 0.0095 0.0417 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0417 0.1159
Echinococcus granulosus hypothetical protein 0.0122 0.0568 0.1781
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Brugia malayi Protein kinase domain containing protein 0.0291 0.1527 0.1527
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0182 0.0912 0.198
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0009 0.0027
Brugia malayi Stress-activated protein kinase jnk-1 0.0247 0.1278 0.1278
Giardia lamblia Encystation-specific protease 0.0249 0.129 0.3577
Entamoeba histolytica protein kinase domain containing protein 0.0249 0.129 1
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Trypanosoma brucei SNF1-related protein kinases, putative 0.0037 0.0089 0.065
Loa Loa (eye worm) AUR protein kinase 0.0177 0.0883 0.0883
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0026 0.0028 0.0079
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Echinococcus multilocularis casein kinase I delta 0.0052 0.0176 0.0383
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0249 0.129 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.003 0.005 0.005
Plasmodium vivax protein kinase Crk2 0.0057 0.0205 0.0555
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0026 0.0157
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0095 0.0417 0.3199
Giardia lamblia Kinase, CAMK CAMKL 0.0045 0.0134 0.0358
Echinococcus multilocularis tyrosine protein kinase Abl 0.0026 0.0028 0.0062
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.006 0.0218 0.0684
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.006 0.0167
Echinococcus granulosus casein kinase i 0.0052 0.0176 0.0553
Brugia malayi Immunoglobulin I-set domain containing protein 0.045 0.2424 0.2424
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0095 0.0417 0.1138
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0501 0.2711 0.8504
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0006 0.0016
Brugia malayi Protein kinase domain containing protein 0.0148 0.0717 0.0717
Loa Loa (eye worm) TK protein kinase 0.0026 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Leishmania major protein kinase, putative 0.0177 0.0883 0.6829
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Brugia malayi Protein kinase domain containing protein 0.0073 0.0293 0.0293
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0148 0.0717 0.225
Schistosoma mansoni protein kinase 0.0022 0.0006 0.0016
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0032 0.006 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Loa Loa (eye worm) hypothetical protein 0.0163 0.0805 0.0805
Echinococcus granulosus cyclin dependent kinase 9 0.006 0.0218 0.0683
Leishmania major casein kinase, putative 0.0052 0.0176 0.1327
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0029 0.0044 0.0293
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0026 0.0028 0.0089
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0205 0.0205
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0052 0.0176 0.1327
Echinococcus multilocularis death associated protein kinase 1 0.0836 0.4605 1
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0095 0.0417 0.1145
Loa Loa (eye worm) TK/ABL protein kinase 0.0026 0.0028 0.0028
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.179 1 1
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0036 0.0086 0.0086
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0136 0.0648 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0026 0.0028 0.0062
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0009 0.0022
Giardia lamblia Kinase, STE STE20 0.0089 0.0383 0.1052
Schistosoma mansoni protein kinase 0.0026 0.0026 0.0072
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0249 0.129 0.2802
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0382
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0026 0.0157
Echinococcus granulosus tyrosine protein kinase Srms 0.0026 0.0028 0.0089
Echinococcus granulosus serine:threonine kinase SAD 1 0.0037 0.0089 0.0281
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0045 0.0137 0.0431
Trypanosoma brucei casein kinase I, isoform 2 0.0052 0.0176 0.1327
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0163 0.0805 0.0805
Loa Loa (eye worm) hypothetical protein 0.0043 0.0123 0.0123
Echinococcus multilocularis beta adrenergic receptor kinase 0.0027 0.0034 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0089 0.0383
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0095 0.0417 0.0905
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0478 0.2581 0.2581
Echinococcus multilocularis casein kinase I alpha 0.0052 0.0176 0.0383
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Trypanosoma brucei protein kinase, putative 0.0249 0.129 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0177 0.0883 0.6829
Entamoeba histolytica protein kinase domain containing protein 0.0194 0.0978 0.7566
Schistosoma mansoni serine/threonine protein kinase 0.0585 0.3188 0.8865
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.006 0.0218 0.0473
Loa Loa (eye worm) AUR protein kinase 0.0177 0.0883 0.0883
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0073 0.0296 0.0927
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Brugia malayi serine/threonine protein kinase 6 0.0177 0.0883 0.0883
Echinococcus multilocularis cyclin dependent kinase 7 0.0092 0.0399 0.0867
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0163 0.0805 0.0805
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0205 0.0571
Toxoplasma gondii hypothetical protein 0.0032 0.006 0.0143
Loa Loa (eye worm) serotonin transporter b 0.0032 0.006 0.006
Leishmania major macrophage migration inhibitory factor-like protein 0.0036 0.0086 0.0627
Schistosoma mansoni protein kinase 0.006 0.0218 0.0606
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0417 0.1159
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0037 0.0089 0.065
Brugia malayi P21-Rho-binding domain containing protein 0.0045 0.0137 0.0137
Onchocerca volvulus 0.0032 0.0059 0.0185
Loa Loa (eye worm) gastrulation defective protein 1 0.0132 0.0627 0.0627
Schistosoma mansoni tyrosine kinase 0.0027 0.0035 0.0097
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0136 0.0648 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0026 0.0028 0.0062
Brugia malayi Protein kinase domain containing protein 0.0136 0.0648 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0708 0.1968
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.0176 0.0782
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Echinococcus multilocularis cyclin dependent kinase 9 0.0068 0.0263 0.0571
Echinococcus multilocularis PAK box P21 Rho binding 0.0045 0.0137 0.0299
Entamoeba histolytica serine/threonine protein kinase, putative 0.0037 0.0089 0.065
Loa Loa (eye worm) AGC/PKA protein kinase 0.0095 0.0417 0.0417
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0057 0.0205 0.0644
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.006 0.0218 0.0684
Onchocerca volvulus 0.0032 0.0059 0.0185
Trichomonas vaginalis STE family protein kinase 0.006 0.0218 0.0973
Echinococcus multilocularis cyclin dependent kinase 0.0057 0.0205 0.0446
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0037 0.0089 0.065
Echinococcus granulosus mitogen activated protein kinase 15 0.0022 0.0006 0.0018
Giardia lamblia Kinase, CMGC GSK 0.0249 0.129 0.3578
Schistosoma mansoni kinase 0.006 0.0218 0.0606
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0026 0.0028 0.0062
Brugia malayi serine/threonine-protein kinase 6 0.0177 0.0883 0.0883
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0009 0.0013
Onchocerca volvulus 0.0052 0.0176 0.0553
Echinococcus granulosus tyrosine protein kinase Src42A 0.0026 0.0028 0.0089
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0008
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0144 0.0693 0.0693
Brugia malayi Bm-MIF-1, identical 0.0036 0.0086 0.0086
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.0176 0.0782
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0036 0.0086 0.0217
Trypanosoma cruzi casein kinase, putative 0.0052 0.0176 0.1327
Loa Loa (eye worm) SRC-1 0.0026 0.0028 0.0028
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0027 0.0034 0.0094
Brugia malayi SH2 domain containing protein 0.0026 0.0028 0.0028
Brugia malayi Furin-like cysteine rich region family protein 0.0444 0.239 0.239
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.0143
Echinococcus granulosus tyrosine kinase 0.0026 0.0028 0.0089
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0032 0.006 0.0189
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0027 0.0034 0.0094
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0026 0.0028 0.0062
Toxoplasma gondii casein kinase I 0.0052 0.0176 0.0467
Echinococcus multilocularis dual specificity mitogen activated protein 0.0089 0.0383 0.0832
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0136 0.0648 0.0648
Schistosoma mansoni sodium/chloride dependent transporter 0.0032 0.006 0.0167
Onchocerca volvulus 0.0026 0.0028 0.0089
Plasmodium vivax casein kinase 1, putative 0.0052 0.0176 0.0475
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0026 0.0028 0.0089
Entamoeba histolytica protein kinase, putative 0.006 0.0218 0.1651
Echinococcus granulosus tyrosine protein kinase Src64B 0.0026 0.0028 0.0089
Giardia lamblia Kinase, AGC PKA 0.0095 0.0417 0.1145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0122 0.0568 0.0568
Plasmodium falciparum protein kinase, putative 0.0026 0.0026 0.0056
Echinococcus multilocularis dual specificity protein kinase clk2 0.0136 0.0648 0.1408
Echinococcus granulosus c src tyrosine kinase 0.0026 0.0028 0.0089
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0205 0.1552
Echinococcus multilocularis tyrosine kinase 0.0026 0.0028 0.0062
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0501 0.2711 0.5887
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0022 0.0006 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Echinococcus granulosus casein kinase I alpha 0.0052 0.0176 0.0553
Onchocerca volvulus 0.0032 0.006 0.0189
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0036 0.0086 0.037
Loa Loa (eye worm) norepinephrine transporter 0.0032 0.006 0.006
Trypanosoma brucei cdc2-related kinase 3 0.0057 0.0205 0.1552
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0026 0.0028 0.0062
Schistosoma mansoni protein kinase 0.0182 0.0912 0.2535
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0045 0.0137 0.0299
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0009 0.0022
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.006
Entamoeba histolytica cell division protein kinase 2, putative 0.0057 0.0205 0.1552
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Echinococcus multilocularis casein kinase I alpha 0.0052 0.0176 0.0383
Loa Loa (eye worm) hypothetical protein 0.0037 0.0089 0.0089
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0026 0.0028 0.0175
Echinococcus granulosus tyrosine protein kinase shark 0.0026 0.0028 0.0089
Trichomonas vaginalis CK1 family protein kinase 0.0052 0.0176 0.0782
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0081 0.0336 0.1055
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0032 0.006 0.0167
Onchocerca volvulus 0.0032 0.006 0.0189
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0028 0.0089
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0057 0.0205 0.0548
Giardia lamblia Kinase, CAMK CAMKL 0.0045 0.0134 0.0358
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0026 0.0028 0.0089
Echinococcus granulosus twitchin 0.0048 0.0153 0.0481
Leishmania major protein kinase, putative 0.0136 0.0648 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0026 0.0028 0.0089
Echinococcus granulosus tyrosine kinase 0.0026 0.0028 0.0089
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0205 0.0555
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0032 0.006 0.0143
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0032 0.0059 0.0059
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0032 0.006 0.0167
Plasmodium falciparum serine/threonine protein kinase, putative 0.0177 0.0883 0.2444
Entamoeba histolytica protein kinase domain containing protein 0.0177 0.0883 0.6829
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0144 0.0693 0.0693
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0131 0.062 0.1345
Schistosoma mansoni sodium-dependent amino acid transporter 0.0032 0.006 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0176 0.0491
Echinococcus multilocularis dual specificity 0.0194 0.0978 0.2123
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0218 0.165
Brugia malayi Cytochrome P450 family protein 0.0032 0.0059 0.0059
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0249 0.129 0.3589
Echinococcus multilocularis Immunoglobulin 0.0027 0.0034 0.0073
Plasmodium falciparum amino acid transporter, putative 0.0032 0.006 0.0151
Toxoplasma gondii histone kinase SNF1, putative 0.0037 0.0089 0.0225
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0883 0.4024
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0022 0.0006 0.0013
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0249 0.129 0.3577
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0478 0.2581 0.8095
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0182 0.0912 0.286
Schistosoma mansoni tyrosine kinase 0.0026 0.0028 0.0079
Echinococcus granulosus cyclin dependent kinase 5 0.0057 0.0205 0.0644
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0036 0.0086 0.0627
Echinococcus granulosus neuroglian 0.0034 0.0073 0.0229
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0657 0.3596 1
Brugia malayi Protein kinase domain containing protein 0.0026 0.0028 0.0028
Onchocerca volvulus 0.0026 0.0028 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0399 0.111
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0028 0.0028
Brugia malayi cyclin-dependent kinase 7 homolog 0.01 0.0444 0.0444
Echinococcus multilocularis PAK box P21 Rho binding 0.006 0.0218 0.0473
Echinococcus granulosus insulin receptor 0.0148 0.0717 0.225
Echinococcus granulosus casein kinase I delta 0.0052 0.0176 0.0553
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0032 0.006 0.0131
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0009 0.0009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0028 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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