TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.345 | Formula: C18H18N2O7
H donors: 2 H acceptors: 4 LogP: 2.57 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(OC)cc(cc1OC)NC(=O)/C=C/c1c(O)cccc1[N+](=O)[O-]
InChi: 1S/C18H18N2O7/c1-25-15-9-11(10-16(26-2)18(15)27-3)19-17(22)8-7-12-13(20(23)24)5-4-6-14(12)21/h4-10,21H,1-3H3,(H,19,22)/b8-7+
InChiKey: JOSBKRVWTUAFNL-BQYQJAHWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Electrophorus electricus	Acetylcholinesterase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	carboxylesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	acetylcholinesterase 1	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	ko:K01049 acetylcholinesterase [EC3.1.1.7], putative	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	Acetylcholinesterase 1 precursor, putative	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Acetylcholinesterase	633 aa	622 aa	24.9 %
Echinococcus multilocularis	BC026374 protein (S09 family)	Acetylcholinesterase	633 aa	690 aa	32.3 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	633 aa	597 aa	25.1 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	633 aa	517 aa	25.1 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	633 aa	576 aa	23.4 %
Echinococcus multilocularis	neuroligin	Acetylcholinesterase	633 aa	507 aa	23.9 %
Onchocerca volvulus		Acetylcholinesterase	633 aa	648 aa	25.3 %
Echinococcus granulosus	BC026374 protein S09 family	Acetylcholinesterase	633 aa	690 aa	31.7 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	633 aa	620 aa	28.4 %
Drosophila melanogaster	CG10175 gene product from transcript CG10175-RE	Acetylcholinesterase	633 aa	549 aa	30.4 %
Onchocerca volvulus	Molybdopterin synthase catalytic subunit homolog	Acetylcholinesterase	633 aa	576 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	ion transport protein	0.0008	0.0029	0.0197
Echinococcus multilocularis	glycine receptor subunit beta	0.005	0.122	0.122
Schistosoma mansoni	calcium-activated potassium channel	0.0162	0.4443	0.7162
Schistosoma mansoni	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0008	0.0029	0.0029
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.005	0.122	0.1967
Echinococcus granulosus	potassium channel subfamily K 8	0.0008	0.0029	0.0047
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0232	0.6468	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Schistosoma mansoni	hypothetical protein	0.0013	0.0158	0.0254
Brugia malayi	beta-lactamase family protein	0.0037	0.0852	0.1438
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0014	0.0188	0.0304
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0008	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0188	0.0304
Echinococcus granulosus	PHD finger protein rhinoceros	0.0013	0.0158	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Brugia malayi	Carboxylesterase family protein	0.0014	0.0188	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0041	0.098	0.098
Echinococcus granulosus	histone lysine methyltransferase setb	0.0043	0.1013	0.1634
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.045	0.076
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Brugia malayi	Bromodomain containing protein	0.0054	0.1331	0.2248
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1991	0.321
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0008	0.0029	0.0049
Giardia lamblia	Kinase, PLK	0.0041	0.098	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.122	0.206
Entamoeba histolytica	hypothetical protein	0.0027	0.0561	0.0826
Schistosoma mansoni	acetylcholine receptor-related	0.0023	0.045	0.0726
Loa Loa (eye worm)	acetyltransferase	0.0047	0.1134	0.1828
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.005	0.122	0.122
Trypanosoma cruzi	polo-like protein kinase, putative	0.0041	0.098	1
Schistosoma mansoni	zinc finger protein	0.0011	0.0099	0.0159
Echinococcus multilocularis	carboxylesterase 5A	0.0082	0.2144	0.2144
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.005	0.122	0.206
Loa Loa (eye worm)	ACC-1 protein	0.005	0.122	0.1967
Echinococcus granulosus	para nitrobenzyl esterase	0.0014	0.0188	0.0304
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0037	0.0845	0.1362
Trichomonas vaginalis	CAMK family protein kinase	0.002	0.0379	0.052
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Schistosoma mansoni	nAChR subunit	0.0023	0.045	0.0726
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.122	0.206
Brugia malayi	hypothetical protein	0.0132	0.3596	0.607
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0213	0.5924	0.9549
Entamoeba histolytica	hypothetical protein	0.0016	0.0244	0.0333
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0.0549	0.0884
Echinococcus multilocularis	zinc finger protein	0.0015	0.0216	0.0216
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.005	0.122	0.1967
Trichomonas vaginalis	CAMK family protein kinase	0.0041	0.098	0.141
Schistosoma mansoni	nAChR subunit	0.005	0.122	0.1967
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.005	0.122	0.1967
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Echinococcus granulosus	lamin	0.0008	0.0032	0.0051
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.005	0.122	0.206
Trichomonas vaginalis	CAMK family protein kinase	0.002	0.0379	0.052
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.045	0.076
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0852	0.1291
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0852	0.0852
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0852	0.122
Toxoplasma gondii	ion channel protein	0.0008	0.0029	0.0299
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.1024	0.165
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Trypanosoma brucei	polo-like protein kinase	0.0041	0.098	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0047	0.1134	0.1134
Echinococcus multilocularis	potassium channel subfamily K 8	0.0008	0.0029	0.0029
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0158	0.1816
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0008	0.0029	0.0049
Onchocerca volvulus		0.0023	0.045	0.0665
Loa Loa (eye worm)	acetylcholine receptor protein	0.0023	0.045	0.0726
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.005	0.122	0.122
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3047	0.4911
Onchocerca volvulus		0.0136	0.3706	0.5474
Loa Loa (eye worm)	uncoordinated protein 58	0.0008	0.0029	0.0047
Mycobacterium ulcerans	lipase LipD	0.0037	0.0852	0.6595
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus multilocularis	lamin dm0	0.0008	0.0032	0.0032
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0852	0.6595
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0014	0.0188	0.0188
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0043	0.1013	0.1634
Echinococcus multilocularis	potassium channel subfamily K 8	0.0008	0.0029	0.0029
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0012	0.0134	0.0216
Schistosoma mansoni	nAChR subunit	0.005	0.122	0.1967
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0852	0.1291
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0852	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus multilocularis	peregrin	0.0016	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0011	0.011	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2144	0.3456
Echinococcus multilocularis	para nitrobenzyl esterase	0.0014	0.0188	0.0188
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0027	0.0561	0.0904
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0102	0.2734	0.4407
Trypanosoma brucei	PAB1-binding protein , putative	0.0011	0.011	0.0848
Entamoeba histolytica	hypothetical protein	0.0066	0.1691	0.258
Loa Loa (eye worm)	jmjC domain-containing protein	0.0017	0.0273	0.0441
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.122	0.206
Loa Loa (eye worm)	PHD-finger family protein	0.0014	0.0206	0.0332
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0012	0.0134	0.0134
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0102	0.2734	0.4615
Plasmodium falciparum	ataxin-2 like protein, putative	0.0011	0.011	0.6885
Onchocerca volvulus		0.0008	0.0029	0.0043
Onchocerca volvulus		0.0037	0.0852	0.1258
Giardia lamblia	DNA repair protein RAD52	0.0232	0.6468	1
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0008	0.0029	0.0039
Onchocerca volvulus		0.0008	0.0032	0.0047
Echinococcus granulosus	small conductance calcium activated potassium	0.0223	0.6204	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.005	0.122	0.1967
Schistosoma mansoni	calcium-activated potassium channel	0.0008	0.0029	0.0047
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0008	0.0029	0.0049
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0023	0.045	0.045
Entamoeba histolytica	hypothetical protein	0.0016	0.0244	0.0333
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0014	0.0188	0.0304
Schistosoma mansoni	serine/threonine protein kinase	0.0041	0.098	0.158
Echinococcus granulosus	geminin	0.0113	0.3046	0.4909
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0008	0.0029	0.0049
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0052	0.1289	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.005	0.122	0.206
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3596	0.5796
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Schistosoma mansoni	nAChR subunit	0.005	0.122	0.1967
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0023	0.045	0.0726
Brugia malayi	Carboxylesterase family protein	0.0014	0.0188	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1452	0.2341
Echinococcus granulosus	BC026374 protein S09 family	0.0014	0.0188	0.0304
Schistosoma mansoni	zinc finger protein	0.0015	0.0216	0.0349
Entamoeba histolytica	hypothetical protein	0.0016	0.0244	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0188	0.0304
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0014	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0188	0.0304
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0852	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0852	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus multilocularis	potassium channel subfamily K	0.0008	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Schistosoma mansoni	lamin	0.0008	0.0032	0.0051
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0008	0.0029	0.0047
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Plasmodium vivax	potassium channel, putative	0.0008	0.0029	0.0299
Echinococcus granulosus	potassium channel subfamily K 8	0.0008	0.0029	0.0047
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0052	0.1289	0.1958
Brugia malayi	Carboxylesterase family protein	0.0014	0.0188	0.0318
Onchocerca volvulus		0.0014	0.0188	0.0278
Mycobacterium ulcerans	carboxylesterase, LipT	0.0014	0.0188	0.1435
Toxoplasma gondii	ABC1 family protein	0.0037	0.0852	1
Onchocerca volvulus		0.0008	0.0029	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0102	0.2734	0.4407
Brugia malayi	hypothetical protein	0.0011	0.011	0.0185
Echinococcus granulosus	lysine specific demethylase 5A	0.0017	0.0273	0.0441
Echinococcus granulosus	Aminotransferase class III	0.0007	0.0004	0.0006
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.2144	0.2144
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.005	0.122	0.1967
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.005	0.122	0.206
Loa Loa (eye worm)	LGC-31 protein	0.005	0.122	0.1967
Plasmodium falciparum	histone acetyltransferase GCN5	0.0012	0.014	0.8843
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0852	0.1291
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0041	0.098	0.158
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0015	0.0219	0.2542
Onchocerca volvulus		0.0136	0.3706	0.5474
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0852	0.8651
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0012	0.0134	0.0216
Echinococcus granulosus	glycine receptor subunit beta	0.005	0.122	0.1967
Trypanosoma cruzi	ISWI complex protein	0.0011	0.0099	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0188	0.0304
Echinococcus granulosus	carboxylesterase 5A	0.0082	0.2144	0.3456
Onchocerca volvulus		0.0243	0.6771	1
Onchocerca volvulus		0.0027	0.0561	0.0828
Brugia malayi	hypothetical protein	0.0023	0.045	0.076
Echinococcus granulosus	jumonji domain containing protein	0.0018	0.0302	0.0486
Schistosoma mansoni	neurotransmitter gated ion channel	0.0023	0.045	0.0726
Schistosoma mansoni	transcription factor LCR-F1	0.0016	0.0244	0.0393
Schistosoma mansoni	acetylcholinesterase	0.0014	0.0188	0.0304
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Echinococcus granulosus	ornithine aminotransferase	0.0007	0.0004	0.0006
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.005	0.122	0.1967
Echinococcus granulosus	calcium activated potassium channel variant	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3706	0.5974
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0027	0.0561	0.0947
Echinococcus granulosus	acetylcholinesterase	0.0082	0.2144	0.3456
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.122	0.206
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0136	0.3706	0.5974
Schistosoma mansoni	neurotransmitter gated ion channel	0.0027	0.0561	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1313	0.2116
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0027	0.0561	0.0947
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0852	0.6595
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0023	0.045	0.045
Schistosoma mansoni	bromodomain containing protein	0.0045	0.1096	0.1766
Schistosoma mansoni	nAChR subunit	0.005	0.122	0.1967
Loa Loa (eye worm)	carboxylesterase	0.0082	0.2144	0.3456
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.005	0.122	0.1967
Trichomonas vaginalis	CAMK family protein kinase	0.0041	0.098	0.141
Schistosoma mansoni	lamin	0.0008	0.0032	0.0051
Schistosoma mansoni	hypothetical protein	0.0014	0.0206	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Trichomonas vaginalis	CAMK family protein kinase	0.0041	0.098	0.141
Plasmodium vivax	SET domain protein, putative	0.0031	0.067	0.7862
Echinococcus granulosus	peregrin	0.0016	0.0237	0.0382
Schistosoma mansoni	nAChR subunit	0.005	0.122	0.1967
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0102	0.2734	0.2734
Brugia malayi	Cation transporter family protein	0.005	0.122	0.206
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0014	0.0188	0.0281
Brugia malayi	beta-lactamase family protein	0.0037	0.0852	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2243	0.3615
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Brugia malayi	Pre-SET motif family protein	0.0031	0.067	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0852	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0041	0.098	0.1477
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.005	0.122	0.1967
Onchocerca volvulus		0.0136	0.3706	0.5474
Schistosoma mansoni	calcium-activated potassium channel	0.0223	0.6204	1
Schistosoma mansoni	nAChR subunit	0.005	0.122	0.1967
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0008	0.0029	0.0049
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0023	0.045	0.076
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0014	0.0188	0.0304
Echinococcus multilocularis	glycine receptor subunit beta	0.005	0.122	0.122
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0014	0.0188	0.0304
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0852	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Onchocerca volvulus		0.0132	0.3596	0.5311
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0023	0.045	0.076
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.005	0.122	0.206
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0027	0.0561	0.0947
Echinococcus multilocularis	twik family of potassium channels	0.0008	0.0029	0.0029
Brugia malayi	Carboxylesterase family protein	0.0082	0.2144	0.3619
Echinococcus multilocularis	neuroligin	0.0014	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Onchocerca volvulus		0.0008	0.0029	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0852	0.1373
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0013	0.0158	0.0158
Trichomonas vaginalis	spcc417.12 protein, putative	0.0014	0.0188	0.0236
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0007	0.0004	0.5
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.6771	1
Schistosoma mansoni	intermediate filament proteins	0.0008	0.0032	0.0051
Schistosoma mansoni	hypothetical protein	0.0113	0.3046	0.4909
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0023	0.045	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus multilocularis	small conductance calcium activated potassium	0.0223	0.6204	0.6204
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0852	0.122
Onchocerca volvulus		0.0008	0.0029	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0852	0.1373
Onchocerca volvulus		0.0023	0.045	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0681	0.1097
Echinococcus multilocularis	ornithine aminotransferase	0.0007	0.0004	0.0004
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0852	0.6595
Echinococcus granulosus	lamin dm0	0.0008	0.0032	0.0051
Brugia malayi	excitatory GABA receptor EXP-1A	0.005	0.122	0.206
Brugia malayi	hypothetical protein	0.0023	0.045	0.076
Onchocerca volvulus		0.0031	0.067	0.099
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0017	0.0273	0.0441
Plasmodium falciparum	ataxin-2 like protein, putative	0.0011	0.011	0.6885
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0852	0.1438
Brugia malayi	Bromodomain containing protein	0.0016	0.0237	0.04
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Onchocerca volvulus		0.005	0.122	0.1802
Loa Loa (eye worm)	bromodomain containing protein	0.0013	0.0178	0.0287
Trichomonas vaginalis	CAMK family protein kinase	0.0041	0.098	0.141
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0007	0.0004	0.0006
Brugia malayi	hypothetical protein	0.0016	0.0244	0.0411
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0852	0.122
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0042	0.0993	0.1601
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0042	0.0993	0.0993
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0102	0.2734	0.2734
Plasmodium vivax	ataxin-2 like protein, putative	0.0011	0.011	0.125
Schistosoma mansoni	hypothetical protein	0.0113	0.3046	0.4909
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1013	0.1634
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0008	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Echinococcus multilocularis	twik family of potassium channels	0.0008	0.0029	0.0029
Brugia malayi	serine/threonine-protein kinase plk-2	0.0041	0.098	0.1654
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Toxoplasma gondii	PHD-finger domain-containing protein	0.0013	0.0158	0.1816
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0016	0.0244	0.0394
Leishmania major	hypothetical protein, conserved	0.0011	0.0099	0.0729
Trichomonas vaginalis	esterase, putative	0.0037	0.0852	0.122
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.005	0.122	0.122
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Leishmania major	hypothetical protein, conserved	0.0011	0.011	0.0848
Brugia malayi	hypothetical protein	0.0023	0.045	0.076
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0014	0.0188	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0188	0.0304
Schistosoma mansoni	BC026374 protein (S09 family)	0.0014	0.0188	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0188	0.0304
Echinococcus multilocularis	calcium activated potassium channel variant	0.0008	0.0029	0.0029
Brugia malayi	PHD-finger family protein	0.0019	0.0324	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2144	0.3456
Brugia malayi	Bromodomain containing protein	0.0028	0.0593	0.1001
Echinococcus multilocularis	ornithine aminotransferase	0.0007	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Schistosoma mansoni	jumonji domain containing protein	0.0033	0.0746	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0158	0.0254
Onchocerca volvulus		0.0014	0.0188	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0102	0.2734	0.4407
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.005	0.122	0.1967
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0852	0.1373
Brugia malayi	Cation transporter family protein	0.005	0.122	0.206
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0025	0.0514	0.0828
Loa Loa (eye worm)	TWK-7 protein	0.0008	0.0029	0.0047
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0102	0.2734	0.4407
Echinococcus granulosus	acetylcholinesterase	0.0082	0.2144	0.3456
Onchocerca volvulus		0.005	0.122	0.1802
Loa Loa (eye worm)	carboxylesterase	0.0014	0.0188	0.0304
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.005	0.122	0.1967
Onchocerca volvulus		0.0027	0.0561	0.0828
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0008	0.0029	0.0047
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0015	0.0219	0.0282
Trypanosoma cruzi	PAB1-binding protein , putative	0.0011	0.011	0.0848
Onchocerca volvulus	Alhambra homolog	0.0013	0.0158	0.0233
Onchocerca volvulus		0.0008	0.0029	0.0043
Brugia malayi	jmjC domain containing protein	0.0042	0.0993	0.1676
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.067	0.1081
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0852	0.8651
Schistosoma mansoni	hypothetical protein	0.0011	0.0099	0.0159
Brugia malayi	jmjC domain containing protein	0.0017	0.0273	0.0462
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0852	0.122
Echinococcus granulosus	twik family of potassium channels	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Entamoeba histolytica	acetyltransferase, GNAT family	0.0012	0.014	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0014	0.0188	0.0304
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.122	0.206
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0008	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Mycobacterium ulcerans	hypothetical protein	0.0052	0.1289	1
Echinococcus multilocularis	geminin	0.0113	0.3046	0.3046
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0025	0.0514	0.0514
Loa Loa (eye worm)	hypothetical protein	0.003	0.0642	0.1035
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0008	0.0029	0.0049
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.1024	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0027	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1214	0.1956
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0852	0.6595
Schistosoma mansoni	gliotactin	0.0014	0.0188	0.0304
Mycobacterium tuberculosis	Probable aminotransferase	0.0052	0.1289	0.1958
Loa Loa (eye worm)	GABA receptor subunit	0.0027	0.0561	0.0904
Echinococcus multilocularis	lamin	0.0008	0.0032	0.0032
Plasmodium falciparum	phd finger protein, putative	0.0013	0.0158	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0563	0.0907
Brugia malayi	acetyltransferase, GNAT family protein	0.0047	0.1134	0.1914
Brugia malayi	follicle stimulating hormone receptor	0.0079	0.2056	0.3471
Loa Loa (eye worm)	acetylcholinesterase 1	0.0082	0.2144	0.3456
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0008	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Toxoplasma gondii	ion channel protein	0.0008	0.0029	0.0299
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0023	0.045	0.0726
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.105	0.1692
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus multilocularis	Aminotransferase class III	0.0007	0.0004	0.0004
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Trypanosoma brucei	ISWI complex protein	0.0011	0.0099	0.0729
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0015	0.0219	0.2542
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0023	0.045	0.0726
Loa Loa (eye worm)	carboxylesterase	0.0014	0.0188	0.0304
Brugia malayi	beta-lactamase	0.0037	0.0852	0.1438
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0008	0.0029	0.0047
Schistosoma mansoni	hypothetical protein	0.0223	0.6204	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0015	0.0219	0.0354
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0016	0.0244	0.0393
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.005	0.122	0.206
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0008	0.0029	0.0049
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0013	0.0158	0.0254
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.045	0.076
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0015	0.0219	0.0282
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0102	0.2734	0.2734
Brugia malayi	hypothetical protein	0.0023	0.045	0.076
Onchocerca volvulus		0.0014	0.0188	0.0278
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0043	0.1013	0.1634
Trichomonas vaginalis	CAMK family protein kinase	0.0041	0.098	0.141
Echinococcus granulosus	nAChR subunit	0.0027	0.0561	0.0904
Entamoeba histolytica	hypothetical protein	0.0016	0.0244	0.0333
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0008	0.0029	0.0049
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0852	0.6595
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.005	0.122	0.206
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.122	0.206
Schistosoma mansoni	lipoxygenase	0.0037	0.0845	0.1362
Brugia malayi	Cation transporter family protein	0.0136	0.3706	0.6256
Echinococcus multilocularis	nAChR subunit	0.0027	0.0561	0.0561
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0023	0.045	0.076
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0102	0.2734	0.4407
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.6569	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0852	0.1291
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0058	0.1452	0.221
Schistosoma mansoni	lipoxygenase	0.0026	0.0528	0.0851
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.2144	0.2144
Onchocerca volvulus	Putative nachr subunit	0.0102	0.2734	0.4038
Onchocerca volvulus		0.0023	0.045	0.0665
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0852	0.1291
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0023	0.045	0.045
Echinococcus multilocularis	lysine specific demethylase 5A	0.0015	0.0235	0.0235
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0852	0.1291
Schistosoma mansoni	kinase	0.0021	0.0395	0.0637
Giardia lamblia	PHD finger protein 15	0.0013	0.0158	0.02
Echinococcus granulosus	nAChR subunit	0.005	0.122	0.1967
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.005	0.122	0.122
Trypanosoma cruzi	ISWI complex protein	0.0011	0.0099	0.0729
Brugia malayi	Intermediate filament tail domain containing protein	0.0008	0.0032	0.0054
Echinococcus granulosus	potassium channel subfamily K	0.0008	0.0029	0.0047
Brugia malayi	hypothetical protein	0.0008	0.0029	0.0049
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Plasmodium falciparum	potassium channel	0.0008	0.0029	0.1649
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0007	0.0004	0.5
Onchocerca volvulus		0.0008	0.0029	0.0043
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0016	0.0244	0.0244
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0008	0.0029	0.0049
Brugia malayi	PHD-finger family protein	0.0013	0.0158	0.0266
Echinococcus granulosus	intermediate filament protein	0.0008	0.0032	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Onchocerca volvulus		0.0014	0.0188	0.0278
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0852	0.1373
Loa Loa (eye worm)	hypothetical protein	0.005	0.122	0.1967
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0052	0.1289	1
Brugia malayi	Pre-SET motif family protein	0.0213	0.5924	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0016	0.0244	0.0244
Toxoplasma gondii	LsmAD domain-containing protein	0.0011	0.011	0.125
Loa Loa (eye worm)	TWK-28 protein	0.0008	0.0029	0.0047
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0047	0.1134	0.1828
Mycobacterium ulcerans	transmembrane cation transporter	0.0008	0.0029	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Schistosoma mansoni	neurotransmitter gated ion channel	0.0023	0.045	0.0726
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0041	0.098	0.1447
Echinococcus granulosus	zinc finger protein	0.0015	0.0216	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0223	0.6204	1
Echinococcus multilocularis	jumonji domain containing protein	0.0018	0.0302	0.0302
Plasmodium vivax	potassium channel, putative	0.0008	0.0029	0.0299
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0008	0.0029	0.0049
Echinococcus granulosus	twik family of potassium channels	0.0008	0.0029	0.0047
Onchocerca volvulus		0.0037	0.0852	0.1258
Echinococcus granulosus	glycine receptor subunit alpha 1	0.005	0.122	0.1967
Giardia lamblia	Histone acetyltransferase GCN5	0.0012	0.014	0.0172
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0037	0.0845	0.0845
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0852	0.122
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0023	0.045	0.0726
Schistosoma mansoni	nAChR subunit	0.005	0.122	0.1967
Trypanosoma cruzi	polo-like protein kinase, putative	0.0041	0.098	1
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0058	0.1452	0.221
Onchocerca volvulus		0.0008	0.0032	0.0047
Loa Loa (eye worm)	ACC-1 protein	0.005	0.122	0.1967
Trypanosoma cruzi	PAB1-binding protein , putative	0.0011	0.011	0.0848
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Brugia malayi	hypothetical protein	0.0023	0.045	0.076
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.005	0.122	0.122
Echinococcus granulosus	glycine receptor subunit beta	0.005	0.122	0.1967
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.005	0.122	0.1967
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0188	0.0304
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0852	0.1373
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0066	0.1691	0.258
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0079	0.2056	0.3314
Plasmodium falciparum	potassium channel	0.0008	0.0029	0.1649
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0041	0.098	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3706	0.5974
Brugia malayi	hypothetical protein	0.0014	0.0188	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0852	0.1373
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0008	0.0032	0.0051
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.067	0.7862
Echinococcus granulosus	fetal alzheimer antigen falz	0.0016	0.0244	0.0394
Onchocerca volvulus		0.0037	0.0852	0.1258
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0638	0.1029
Echinococcus granulosus	glycine receptor subunit alpha 1	0.005	0.122	0.1967
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.067	0.1081
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.005	0.122	0.122
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0052	0.1289	0.1869
Onchocerca volvulus		0.0008	0.0029	0.0043
Toxoplasma gondii	PHD-finger domain-containing protein	0.0013	0.0158	0.1816
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0852	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0041	0.098	0.158
Loa Loa (eye worm)	intermediate filament protein	0.0008	0.0032	0.0051
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0012	0.0134	0.0216
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0136	0.3706	0.5974
Schistosoma mansoni	twik family of potassium channels-related	0.0008	0.0029	0.0047
Echinococcus multilocularis	musashi	0.0008	0.0032	0.0032
Brugia malayi	Carboxylesterase family protein	0.0014	0.0188	0.0318
Echinococcus granulosus	neuroligin	0.0014	0.0188	0.0304
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0017	0.0273	0.0441
Trichomonas vaginalis	CAMK family protein kinase	0.0041	0.098	0.141
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0852	0.1373
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0014	0.0188	0.0281
Onchocerca volvulus		0.0014	0.0188	0.0278
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0008	0.0029	0.0049
Leishmania major	hypothetical protein, conserved	0.0037	0.0852	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0032	0.0051
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.005	0.122	0.1967
Trichomonas vaginalis	CAMK family protein kinase	0.0041	0.098	0.141
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0008	0.0029	0.0049
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0852	0.1291
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.067	0.067
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0029	0.0047
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.005	0.122	0.206
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0027	0.0561	0.0947
Echinococcus granulosus	glycine receptor subunit alpha 1	0.005	0.122	0.1967
Schistosoma mansoni	calcium-activated potassium channel	0.0008	0.0029	0.0047
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0027	0.0561	0.0904
Echinococcus multilocularis	nAChR subunit	0.005	0.122	0.122
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0852	0.6595
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0007	0.0004	0.0006
Loa Loa (eye worm)	PHD-finger family protein	0.0013	0.0158	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0852	0.1373
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0014	0.0188	0.0281
Onchocerca volvulus		0.005	0.122	0.1802
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.005	0.122	0.206
Brugia malayi	hypothetical protein	0.0008	0.0029	0.0049
Brugia malayi	Carboxylesterase family protein	0.0082	0.2144	0.3619
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0852	0.1373
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0043	0.1013	0.1013
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0008	0.0029	0.0047
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.005	0.122	0.122
Schistosoma mansoni	nAChR subunit	0.0023	0.045	0.0726
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0008	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0561	0.0904
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0082	0.2144	0.3456
Schistosoma mansoni	hypothetical protein	0.0016	0.0244	0.0393
Brugia malayi	intermediate filament protein	0.0008	0.0032	0.0054
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.005	0.122	0.1967
Loa Loa (eye worm)	hypothetical protein	0.0023	0.045	0.0726
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.005	0.122	0.1967
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0852	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0022	0.042	0.0677
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0015	0.0219	0.2542
Onchocerca volvulus		0.0008	0.0029	0.0043
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0008	0.0029	0.0029

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12.77 uM	Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method	ChEMBL.	24675179
Inhibition (binding)	= 35.4 %	Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method	ChEMBL.	24675179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3236087

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1884907