Detailed information for compound 18887

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 534.471 | Formula: C20H30N4O13
  • H donors: 8 H acceptors: 12 LogP: -2.44 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)C[C@@H](C(=O)N[C@H](C(=O)O)CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)CC(=O)O)C
  • InChi: 1S/C20H30N4O13/c1-8(21-16(32)10(6-13(27)28)24-19(36)37-20(2,3)4)15(31)22-9(5-12(25)26)17(33)23-11(18(34)35)7-14(29)30/h8-11H,5-7H2,1-4H3,(H,21,32)(H,22,31)(H,23,33)(H,24,36)(H,25,26)(H,27,28)(H,29,30)(H,34,35)/t8-,9-,10-,11-/m0/s1
  • InChiKey: JBYSKITZHJNPOE-NAKRPEOUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0358 0.0985 0.1574
Brugia malayi GnHR receptor homolog 0.0358 0.0985 0.2069
Brugia malayi Trypsin-like protease protein 5 0.0076 0.0169 0.0354
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0332 0.091 0.3047
Mycobacterium tuberculosis Probable oxidoreductase 0.0369 0.1017 0.3407
Mycobacterium ulcerans glutaminase 0.0851 0.241 1
Brugia malayi prolyl oligopeptidase family protein 0.0123 0.0305 0.064
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0286 0.0286
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Onchocerca volvulus 0.0136 0.0342 0.082
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0389
Schistosoma mansoni neurotransmitter gated ion channel 0.0073 0.0161 0.0257
Onchocerca volvulus 0.0084 0.0192 0.0459
Entamoeba histolytica hypothetical protein 0.0036 0.0054 0.1353
Schistosoma mansoni hypothetical protein 0.0358 0.0985 0.1574
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0123 0.0305 0.064
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0123 0.0305 0.0487
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0082 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0019 0.0041
Echinococcus granulosus tachykinin peptides receptor 99D 0.0358 0.0985 0.0985
Schistosoma mansoni alpha-1 adrenergic receptor 0.0358 0.0985 0.1574
Leishmania major acetoin dehydrogenase e3 component-like protein 0.005 0.0095 0.0199
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0062 0.0209
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Loa Loa (eye worm) hypothetical protein 0.0082 0.0187 0.0299
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0039 0.0063
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0037 0.0475
Mycobacterium tuberculosis Probable sulfatase 0.0018 0 0.0001
Brugia malayi hypothetical protein 0.0018 0 0.0001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0358 0.0985 0.0985
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0136 0.0342 0.0719
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.004 0.0095
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.005 0.0095 0.0284
Schistosoma mansoni biogenic amine (5HT) receptor 0.2183 0.6261 1
Plasmodium falciparum thioredoxin reductase 0.005 0.0095 0.2511
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.005 0.0095 0.3643
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0136 0.0342 0.0342
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0063 0.013 0.0208
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.005 0.0095 0.0199
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0215 0.0343
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0389
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.004 0.102
Echinococcus multilocularis sodium and chloride dependent glycine 0.0082 0.0185 0.0185
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0191 0.0638
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0358 0.0985 0.0985
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0286 0.0457
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1243 0.3543 0.744
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni histamine h1 receptor 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0048 0.0088 0.0141
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Loa Loa (eye worm) hypothetical protein 0.0185 0.0483 0.0771
Schistosoma mansoni hypothetical protein 0.0041 0.0068 0.0108
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0062 0.0148
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0286 0.1892
Onchocerca volvulus Putative nachr subunit 0.0136 0.0342 0.082
Echinococcus multilocularis lamin 0.0084 0.0192 0.0192
Mycobacterium tuberculosis Probable dehydrogenase 0.0332 0.091 0.3047
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0191 0.0457
Onchocerca volvulus 0.0358 0.0985 0.2362
Onchocerca volvulus 0.0136 0.0342 0.082
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0123 0.0305 0.0912
Echinococcus granulosus transmembrane protease serine 3 0.0076 0.0169 0.0169
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0072 0.0115
Echinococcus multilocularis protein patched 0.0043 0.0072 0.0072
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0136 0.0342 0.0342
Onchocerca volvulus 0.0136 0.0342 0.082
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Brugia malayi Pre-SET motif family protein 0.0185 0.0483 0.1014
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0063 0.013 0.013
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0014 0.0022
Brugia malayi intermediate filament protein 0.0084 0.0192 0.0403
Brugia malayi G-protein coupled receptor 0.0358 0.0985 0.2069
Plasmodium vivax thioredoxin reductase, putative 0.0146 0.037 0.7597
Trichomonas vaginalis esterase, putative 0.0039 0.0062 0.0149
Brugia malayi chromobox protein homolog 3 0.0078 0.0174 0.0365
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0077 0.0123
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0056 0.1421
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0063 0.1647
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0073 0.0161 0.0338
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0127 0.0204
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Loa Loa (eye worm) glutathione reductase 0.0146 0.037 0.0591
Loa Loa (eye worm) inositol-1 0.0037 0.0056 0.0089
Leishmania major cytochrome p450-like protein 0.0026 0.0025 0.0052
Loa Loa (eye worm) G-protein coupled receptor 0.0358 0.0985 0.1574
Echinococcus multilocularis fmrfamide receptor 0.0358 0.0985 0.0985
Onchocerca volvulus 0.0358 0.0985 0.2362
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0169
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0062 0.1639
Entamoeba histolytica prolyl oligopeptidase family protein 0.0123 0.0305 1
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0123 0.0305 0.073
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0029 0.0034 0.0034
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0136 0.0342 0.0547
Schistosoma mansoni neuropeptide receptor 0.0358 0.0985 0.1574
Mycobacterium ulcerans hypothetical protein 0.0022 0.0012 0.0052
Loa Loa (eye worm) hypothetical protein 0.0052 0.01 0.016
Leishmania major hypothetical protein, conserved 0.0039 0.0062 0.0131
Schistosoma mansoni hypothetical protein 0.0041 0.0068 0.0108
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0286 0.0457
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0082 0.0185 0.0296
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0127 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0095 0.0199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0185 0.0483 0.1444
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0014 0.0014
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0467 0.1298 0.4348
Loa Loa (eye worm) ACC-1 protein 0.0136 0.0342 0.0547
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Loa Loa (eye worm) neuropeptide F receptor 0.0358 0.0985 0.1574
Schistosoma mansoni glutaminase 0.0851 0.241 0.3849
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0191 0.0457
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0358 0.0985 0.2069
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0136 0.0342 0.0547
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0062 0.0259
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0077 0.0161
Brugia malayi Thioredoxin reductase 0.0146 0.037 0.0777
Schistosoma mansoni ets-related 0.024 0.0642 0.1025
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0095 0.0199
Schistosoma mansoni nAChR subunit 0.0136 0.0342 0.0547
Schistosoma mansoni chromobox protein 0.0139 0.035 0.0559
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.0305 0.064
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0136 0.0342 0.0342
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0056 0.0117
Loa Loa (eye worm) neuropeptide F receptor 0.0358 0.0985 0.1574
Echinococcus granulosus tm gpcr rhodopsin 0.0358 0.0985 0.0985
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0358 0.0985 0.1574
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Entamoeba histolytica hypothetical protein 0.0036 0.0054 0.1353
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0286 0.9365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0077 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Onchocerca volvulus 0.0073 0.0161 0.0385
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0015 0.0327
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0136 0.0342 0.0342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0073 0.0161 0.0338
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0136 0.0342 0.0342
Giardia lamblia NADH oxidase lateral transfer candidate 0.005 0.0095 0.3105
Schistosoma mansoni neuropeptide f receptor 76f 0.0358 0.0985 0.1574
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0012 0.0096
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0003 0.0008
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0177 0.0283
Toxoplasma gondii hypothetical protein 0.0082 0.0185 0.0555
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.017 0.0406
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0123 0.0305 1
Toxoplasma gondii prolyl endopeptidase 0.1173 0.3342 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0098
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.005 0.0095 0.2511
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0062 0.0099
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Brugia malayi beta-lactamase 0.0039 0.0062 0.0131
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0358 0.0985 0.1574
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0014 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0149
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3476 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0191 0.0457
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.0674 0.2258
Brugia malayi Ets-domain containing protein 0.0079 0.0177 0.0372
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0072 0.0172
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0076 0.0169 0.0169
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0342 0.0719
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0369 0.1017 0.7835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0056 0.0167
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0076 0.0169 0.0269
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0136 0.0342 0.0547
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0358 0.0985 0.1574
Schistosoma mansoni opsin-like receptor 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0076 0.0169 0.0269
Brugia malayi Melatonin receptor type 1A 0.0358 0.0985 0.2069
Onchocerca volvulus 0.0136 0.0342 0.082
Echinococcus multilocularis prolyl endopeptidase 0.1173 0.3342 0.3342
Trichomonas vaginalis set domain proteins, putative 0.146 0.4171 1
Brugia malayi neuropeptide F receptor 0.0358 0.0985 0.2069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0054 0.0054
Treponema pallidum NADH oxidase 0.005 0.0095 0.0421
Toxoplasma gondii exonuclease III APE 0.0039 0.0062 0.0186
Loa Loa (eye worm) hypothetical protein 0.0061 0.0125 0.02
Brugia malayi Cation transporter family protein 0.0136 0.0342 0.0719
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0192 0.0403
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0286 0.1188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0177 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Brugia malayi Inositol-1 0.0037 0.0056 0.0117
Echinococcus multilocularis somatostatin receptor 0.0358 0.0985 0.0985
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0185 0.0483 0.0771
Loa Loa (eye worm) hypothetical protein 0.0482 0.1342 0.2143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0079 0.0126
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0034 0.0055
Echinococcus multilocularis enteropeptidase 0.0076 0.0169 0.0169
Schistosoma mansoni sodium/chloride dependent transporter 0.0482 0.1342 0.2143
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0015 0.0044
Loa Loa (eye worm) serotonin transporter b 0.0482 0.1342 0.2143
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0358 0.0985 0.2069
Loa Loa (eye worm) glutaminase 2 0.0851 0.241 0.3849
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0014 0.0014
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0015 0.0023
Onchocerca volvulus 0.0076 0.0169 0.0403
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0123 0.0305 0.0487
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0482 0.1342 0.2143
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0012 0.0052
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0082 0.0185 0.0296
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0146 0.037 0.124
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0358 0.0985 0.0985
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0467 0.1298 0.2726
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1173 0.3342 0.5337
Loa Loa (eye worm) hypothetical protein 0.0082 0.0185 0.0296
Echinococcus granulosus expressed conserved protein 0.0093 0.0219 0.0219
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0136 0.0342 0.0547
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0082 0.0185 0.0185
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0136 0.0342 0.0547
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0191 0.5114
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0062 0.162
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0332 0.091 0.7009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0076 0.0169 0.0354
Brugia malayi N-terminal motif family protein 0.0187 0.0489 0.1028
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) melatonin receptor type 1A 0.0358 0.0985 0.1574
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0003 0.0003
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0177 0.0177
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0136 0.0342 0.0547
Echinococcus multilocularis serotonin receptor 0.2183 0.6261 0.6261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Plasmodium vivax amine transporter, putative 0.0082 0.0185 0.3648
Schistosoma mansoni inositol monophosphatase 0.0037 0.0056 0.0089
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0358 0.0985 0.1574
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0241 0.0384
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0062 0.0062
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0123 0.0305 0.064
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Echinococcus multilocularis G-protein coupled receptor, putative 0.0358 0.0985 0.0985
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Onchocerca volvulus 0.0136 0.0342 0.082
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0209
Loa Loa (eye worm) hypothetical protein 0.0067 0.0144 0.023
Echinococcus granulosus biogenic amine 5HT receptor 0.1112 0.3165 0.3165
Loa Loa (eye worm) prolyl oligopeptidase 0.0123 0.0305 0.0487
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0062 0.0148
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0358 0.0985 0.1574
Schistosoma mansoni chromobox protein 0.0023 0.0015 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0062 0.0149
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0286 0.0457
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0062 0.0209
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0359 0.0359
Brugia malayi Cytochrome P450 family protein 0.0026 0.0025 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0305 0.073
Echinococcus multilocularis neuropeptides capa receptor 0.0358 0.0985 0.0985
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.004 0.0095
Echinococcus granulosus bloom syndrome protein 0.0045 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni chromobox protein 0.0139 0.035 0.0559
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0358 0.0985 0.1574
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0123 0.0305 0.0487
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0358 0.0985 0.1574
Onchocerca volvulus 0.0063 0.013 0.0312
Brugia malayi 6-phosphofructokinase 0.0117 0.0286 0.0601
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1112 0.3165 0.3165
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0085 0.0194 0.0194
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0358 0.0985 0.0985
Echinococcus multilocularis glycine receptor subunit beta 0.0136 0.0342 0.0342
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0063 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Loa Loa (eye worm) TYRA-2 protein 0.0358 0.0985 0.1574
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0209
Trypanosoma brucei prolyl endopeptidase 0.1173 0.3342 0.7017
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Onchocerca volvulus 0.146 0.4171 1
Echinococcus granulosus G protein coupled receptor 139 0.0358 0.0985 0.0985
Brugia malayi G protein-coupled receptor 0.0358 0.0985 0.2069
Onchocerca volvulus 0.0023 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0023
Onchocerca volvulus 0.0358 0.0985 0.2362
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.004 0.0544
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.005 0.0095 0.0095
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0358 0.0985 0.2362
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0098
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0136 0.0342 0.0342
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0003 0.0008
Plasmodium falciparum peptidase, putative 0.0123 0.0305 0.822
Echinococcus granulosus sodium and chloride dependent glycine 0.0082 0.0185 0.0185
Onchocerca volvulus 0.0073 0.0161 0.0385
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0082 0.0185 0.0296
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0296
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.005 0.0095 0.0152
Loa Loa (eye worm) hypothetical protein 0.0761 0.215 0.3433
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0127 0.0382
Loa Loa (eye worm) hypothetical protein 0.0082 0.0185 0.0296
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.005 0.0095 0.0199
Schistosoma mansoni nAChR subunit 0.0136 0.0342 0.0547
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0018 0.013
Schistosoma mansoni hypothetical protein 0.0446 0.1238 0.1978
Echinococcus granulosus prolyl endopeptidase 0.1173 0.3342 0.3342
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0127 0.0127
Loa Loa (eye worm) GABA receptor subunit 0.0073 0.0161 0.0257
Loa Loa (eye worm) hypothetical protein 0.0482 0.1342 0.2143
Brugia malayi CHE-14 protein 0.0043 0.0072 0.0151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0062 0.0131
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.004 0.0095
Schistosoma mansoni nAChR subunit 0.0136 0.0342 0.0547
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni cpg binding protein 0.0031 0.0039 0.0063
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0136 0.0342 0.0342
Onchocerca volvulus 0.0076 0.0169 0.0403
Brugia malayi prolyl oligopeptidase family protein 0.1173 0.3342 0.7017
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0014 0.0014
Onchocerca volvulus 0.0063 0.013 0.0312
Echinococcus multilocularis protein dispatched 1 0.0049 0.009 0.009
Loa Loa (eye worm) beta-lactamase 0.0039 0.0062 0.01
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.005 0.0095 0.1715
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0358 0.0985 0.1574
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0054 0.0054
Echinococcus granulosus orexin receptor type 2 0.0358 0.0985 0.0985
Echinococcus granulosus dro:myosuppressin receptor 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0482 0.1342 0.2143
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0136 0.0342 0.0342
Schistosoma mansoni nAChR subunit 0.0136 0.0342 0.0547
Brugia malayi putative neuropeptide receptor 0.0358 0.0985 0.2069
Echinococcus multilocularis chromobox protein 1 0.0139 0.035 0.035
Onchocerca volvulus 0.0358 0.0985 0.2362
Schistosoma mansoni neuropeptide receptor 0.0358 0.0985 0.1574
Trichomonas vaginalis glutaminase, putative 0.0851 0.241 0.5778
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.005 0.0095 0.0095
Toxoplasma gondii hypothetical protein 0.0123 0.0305 0.0912
Brugia malayi CXXC zinc finger family protein 0.0031 0.0039 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0026 0.006
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0286 0.0601
Echinococcus granulosus peptide allatostatin:somatostatin 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.01
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0123 0.0305 0.0305
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0136 0.0342 0.0719
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0358 0.0985 0.2069
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0123 0.0305 0.0305
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0062 0.0209
Brugia malayi hypothetical protein 0.0253 0.0679 0.1426
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0358 0.0985 0.0985
Brugia malayi Cation transporter family protein 0.0136 0.0342 0.0719
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0136 0.0342 0.0719
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0269
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0079 0.0166
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0359 0.0359
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0136 0.0342 0.0547
Onchocerca volvulus 0.0076 0.0169 0.0403
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0467 0.1298 0.2726
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0079 0.0188
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Echinococcus granulosus neuropeptides capa receptor 0.0358 0.0985 0.0985
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0062 0.01
Schistosoma mansoni nAChR subunit 0.0136 0.0342 0.0547
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0127 0.0529
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0149
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0073 0.0161 0.0257
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Echinococcus multilocularis chromobox protein 1 0.0139 0.035 0.035
Plasmodium falciparum amino acid transporter, putative 0.0082 0.0185 0.4972
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0015 0.00000000076279
Schistosoma mansoni DNA helicase recq5 0.0019 0.0003 0.0004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0056 0.0118
Schistosoma mansoni inositol monophosphatase 0.0037 0.0056 0.0089
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0015 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.013 0.0274
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0127 0.0204
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0035 0.0083
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.1664 0.4762 0.7606
Trypanosoma brucei oligopeptidase b 0.0467 0.1298 0.2726
Schistosoma mansoni acetylcholine receptor subunit beta 0.0063 0.013 0.0208
Schistosoma mansoni hypothetical protein 0.0036 0.0054 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0019 0.0456
Brugia malayi Cation transporter family protein 0.0136 0.0342 0.0719
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0025 0.0039
Echinococcus granulosus g-protein coupled receptor 0.0358 0.0985 0.0985
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0062 0.0149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0035 0.0083
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0082 0.0185 0.0296
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0062 0.0131
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0136 0.0342 0.0342
Onchocerca volvulus 0.0358 0.0985 0.2362
Echinococcus granulosus neuropeptide receptor 0.0358 0.0985 0.0985
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0014 0.0014
Leishmania major oligopeptidase b 0.0467 0.1298 0.2726
Schistosoma mansoni hypothetical protein 0.0693 0.1954 0.3121
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0014 0.0014
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0095 0.0199
Schistosoma mansoni hypothetical protein 0.0041 0.0068 0.0108
Mycobacterium tuberculosis Probable peptidase 0.0467 0.1298 0.4348
Echinococcus multilocularis musashi 0.0084 0.0192 0.0192
Trypanosoma cruzi oligopeptidase b 0.0467 0.1298 0.2726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0077 0.0123
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0136 0.0342 0.0719
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0079 0.0166
Schistosoma mansoni hypothetical protein 0.0041 0.0068 0.0108
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.005 0.0095 0.0199
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.005 0.0095 0.1715
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0025 0.0039
Echinococcus granulosus sex peptide receptor 0.0358 0.0985 0.0985
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0269
Schistosoma mansoni myosin xvIII 0.0358 0.0985 0.1574
Schistosoma mansoni nAChR subunit 0.0136 0.0342 0.0547
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0015 0.0031
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0342 0.0719
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0123 0.0305 0.064
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0018 0.0039
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0123 0.0305 0.0305
Brugia malayi prolyl oligopeptidase family protein 0.0123 0.0305 0.064
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0045 0.0149
Brugia malayi Fli-1 protein 0.024 0.0642 0.1348
Echinococcus multilocularis Chromo domain 0.0023 0.0015 0.0015
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0056 0.0117
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0003 0.0005
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0136 0.0342 0.0719
Echinococcus granulosus neuropeptide Y receptor 0.0358 0.0985 0.0985
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0161 0.0256
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0014 0.0022
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0003 0.0004
Echinococcus granulosus g protein coupled receptor 0.0358 0.0985 0.0985
Echinococcus multilocularis neuropeptide s receptor 0.0358 0.0985 0.0985
Onchocerca volvulus 0.0039 0.0062 0.0149
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0035 0.0083
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0003 0.0072
Brugia malayi beta-lactamase family protein 0.0039 0.0062 0.0131
Brugia malayi G-protein coupled receptor 0.0358 0.0985 0.2069
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0095 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Brugia malayi glutathione reductase 0.0146 0.037 0.0777
Loa Loa (eye worm) acetylcholine receptor protein 0.0063 0.013 0.0208
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0056 0.0133
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0019 0.0058
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.004 0.0095
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0136 0.0342 0.0342
Echinococcus multilocularis neuropeptide receptor A26 0.0358 0.0985 0.0985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0077 0.0077
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0056 0.0118
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1173 0.3342 0.5337
Echinococcus granulosus 7tm_1 domain containing protein 0.0358 0.0985 0.0985
Brugia malayi hypothetical protein 0.0076 0.0169 0.0354
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.004 0.012
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0286 0.0601
Leishmania major hypothetical protein, conserved 0.0024 0.0019 0.0041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0062 0.0259
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni microtubule-associated protein tau 0.0752 0.2125 0.3393
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0555
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.1238 0.1238
Brugia malayi CHD4 protein 0.0024 0.002 0.0042
Echinococcus granulosus allatostatin A receptor 0.0358 0.0985 0.0985
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0056 0.0056
Echinococcus multilocularis neuropeptide Y receptor 0.0358 0.0985 0.0985
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0358 0.0985 0.0985
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0019 0.0041
Echinococcus granulosus voltage gated potassium channel 0.0029 0.0034 0.0034
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.004 0.102
Onchocerca volvulus 0.0039 0.0062 0.0149
Entamoeba histolytica hypothetical protein 0.0073 0.0161 0.5038
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0467 0.1298 0.2726
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0063 0.013 0.013
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0215 0.0343
Onchocerca volvulus 0.0082 0.0185 0.0443
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.004 0.012
Schistosoma mansoni opsin-like receptor 0.0358 0.0985 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0174 0.0416
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Echinococcus granulosus g protein coupled receptor 0.0358 0.0985 0.0985
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0062 0.0258
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0136 0.0342 0.0342
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0358 0.0985 0.0985
Echinococcus granulosus cpg binding protein 0.0033 0.0045 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0149
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0035 0.0083
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.004 0.0095
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0085 0.0194 0.0194
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0191 0.3759
Loa Loa (eye worm) hypothetical protein 0.0187 0.0489 0.0782
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0296
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0015 0.0023
Brugia malayi hypothetical protein 0.0036 0.0054 0.0113
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0555
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) prolyl oligopeptidase 0.0123 0.0305 0.0487
Echinococcus granulosus tm gpcr rhodopsin 0.1187 0.3383 0.3383
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0085 0.0194 0.0407
Echinococcus granulosus geminin 0.0693 0.1954 0.1954
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0286 0.9365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0036 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0018 0.0043
Giardia lamblia Alanyl dipeptidyl peptidase 0.0123 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0617 0.1735 0.277
Echinococcus granulosus neuropeptide receptor A26 0.0358 0.0985 0.0985
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0062 0.0131
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0072 0.0072
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0062 0.0062
Schistosoma mansoni biogenic amine receptor 0.0358 0.0985 0.1574
Trypanosoma cruzi oligopeptidase b 0.0467 0.1298 0.2726
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.002 0.0032
Brugia malayi follicle stimulating hormone receptor 0.0812 0.2298 0.4826
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0369 0.1017 0.3407
Echinococcus multilocularis conserved hypothetical protein 0.0691 0.1947 0.1947
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0358 0.0985 0.1574
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Schistosoma mansoni biogenic amine (5HT) receptor 0.1112 0.3165 0.5055
Entamoeba histolytica hypothetical protein 0.0036 0.0054 0.1353
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0123 0.0305 0.0487
Loa Loa (eye worm) ACC-1 protein 0.0136 0.0342 0.0547
Trypanosoma brucei C-8 sterol isomerase, putative 0.1664 0.4762 1
Schistosoma mansoni nAChR subunit 0.0136 0.0342 0.0547
Onchocerca volvulus 0.0082 0.0185 0.0443
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0019 0.0101
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0467 0.1298 0.2726
Echinococcus multilocularis acylamino acid releasing enzyme 0.0123 0.0305 0.0305
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0015 0.0034
Schistosoma mansoni neurotransmitter gated ion channel 0.0063 0.013 0.0208
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0076 0.0169 0.0269
Entamoeba histolytica prolyl oligopeptidase family protein 0.0123 0.0305 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0358 0.0985 0.1574
Schistosoma mansoni nAChR subunit 0.0063 0.013 0.0208
Schistosoma mansoni sodium-dependent amino acid transporter 0.0082 0.0185 0.0296
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0 0.0001
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0014 0.0028
Loa Loa (eye worm) norepinephrine transporter 0.0482 0.1342 0.2143
Onchocerca volvulus 0.0358 0.0985 0.2362
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0082 0.0185 0.0185
Echinococcus multilocularis sex peptide receptor 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0358 0.0985 0.0985
Echinococcus granulosus acylamino acid releasing enzyme 0.0123 0.0305 0.0305
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0185 0.0483 0.0483
Schistosoma mansoni nAChR subunit 0.0063 0.013 0.0208
Loa Loa (eye worm) trypsin family protein 0.0076 0.0169 0.0269
Brugia malayi G protein-coupled receptor F59B2.13 0.0358 0.0985 0.2069
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0358 0.0985 0.0985
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0062 0.0131
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0358 0.0985 0.0985
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0286 0.0457
Echinococcus granulosus sodium and chloride dependent glycine 0.0082 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0185 0.0483 0.0483
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0014 0.0022
Loa Loa (eye worm) glutaminase 0.0851 0.241 0.3849
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0369 0.1017 0.3407
Trypanosoma cruzi prolyl endopeptidase 0.1173 0.3342 0.7017
Mycobacterium ulcerans epimerase 0.0022 0.0012 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0015 0.0034
Echinococcus granulosus lamin 0.0084 0.0192 0.0192
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0015 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0019 0.0041
Brugia malayi Trypsin family protein 0.0076 0.0169 0.0354
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Entamoeba histolytica hypothetical protein 0.0036 0.0054 0.1353
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Brugia malayi Protein cec-1. 0.0023 0.0015 0.0031
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0062 0.0209
Schistosoma mansoni amine GPCR 0.0358 0.0985 0.1574
Onchocerca volvulus 0.0061 0.0125 0.0299
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0358 0.0985 0.0985
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0185 0.3648
Brugia malayi Trypsin family protein 0.0076 0.0169 0.0354
Onchocerca volvulus 0.0358 0.0985 0.2362
Loa Loa (eye worm) hypothetical protein 0.0076 0.0169 0.0269
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0063 0.013 0.0274
Loa Loa (eye worm) hypothetical protein 0.0076 0.0169 0.0269
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0025 0.0052
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0236 0.7633
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0015 0.0327
Echinococcus multilocularis glycoprotein Antigen 5 0.0076 0.0169 0.0169
Brugia malayi Cytochrome P450 family protein 0.0026 0.0025 0.0052
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0014 0.0014
Onchocerca volvulus Neuropeptide F receptor homolog 0.0358 0.0985 0.2362
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0084 0.0192 0.0306
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Echinococcus multilocularis G protein coupled receptor 139 0.0358 0.0985 0.0985
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0014 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0185 0.0483 0.0483
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0136 0.0342 0.0719
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0192 0.0306
Onchocerca volvulus 0.0039 0.0062 0.0149
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0389
Echinococcus multilocularis lamin dm0 0.0084 0.0192 0.0192
Plasmodium vivax glutathione reductase, putative 0.0146 0.037 0.7597
Schistosoma mansoni DNA helicase recq1 0.0019 0.0003 0.0004
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0015 0.00000000076279
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0123 0.0305 0.0912
Echinococcus multilocularis neuropeptide receptor 0.0358 0.0985 0.0985
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0082 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.002
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.004 0.1303
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0342 0.0719
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0045 0.0344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0063 0.013 0.0208
Echinococcus multilocularis dro:myosuppressin receptor 0.0358 0.0985 0.0985
Onchocerca volvulus 0.0031 0.0039 0.0094
Brugia malayi Serotonin receptor 0.0819 0.2317 0.4866
Onchocerca volvulus 0.0136 0.0342 0.082
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0056 0.0117
Brugia malayi sulfakinin receptor protein 0.0358 0.0985 0.2069
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0076 0.0169 0.0269
Schistosoma mansoni patched 1 0.0043 0.0072 0.0115
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0082 0.0185 0.0185
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.002 0.002
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0085 0.0194 0.031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0127 0.0529
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0136 0.0342 0.0547
Echinococcus granulosus nAChR subunit 0.0073 0.0161 0.0161
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Onchocerca volvulus 0.0063 0.013 0.0312
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni chromobox protein 0.0023 0.0015 0.0023
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0015 0.0015
Brugia malayi hypothetical protein 0.0063 0.013 0.0274
Brugia malayi hypothetical protein 0.0024 0.0019 0.0041
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Brugia malayi hypothetical protein 0.0082 0.0185 0.0389
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0082 0.0185 0.0185
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0127 0.0268
Brugia malayi Sulfatase family protein 0.0018 0 0.0001
Onchocerca volvulus Prolyl endopeptidase homolog 0.1173 0.3342 0.8012
Loa Loa (eye worm) hypothetical protein 0.0082 0.0185 0.0296
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0015 0.0034
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0136 0.0342 0.0342
Entamoeba histolytica hypothetical protein 0.0023 0.0015 0.00000000076279
Mycobacterium tuberculosis Probable reductase 0.0332 0.091 0.3047
Onchocerca volvulus 0.0207 0.0548 0.1314
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0191 0.04
Brugia malayi beta-lactamase family protein 0.0039 0.0062 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0185 0.0483 0.0771
Echinococcus granulosus glycine receptor subunit alpha 1 0.0136 0.0342 0.0342
Onchocerca volvulus 0.0358 0.0985 0.2362
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1187 0.3383 0.3383
Mycobacterium ulcerans hypothetical protein 0.0039 0.0062 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1664 0.4762 1
Schistosoma mansoni ap endonuclease 0.0039 0.0062 0.0099
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0358 0.0985 0.0985
Trichomonas vaginalis hypothetical protein 0.0023 0.0015 0.0034
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0082 0.0185 0.0185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0088 0.0185
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Mycobacterium ulcerans endonuclease IV 0.0084 0.0191 0.0791
Leishmania major trypanothione reductase 0.0146 0.037 0.0777
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0236 0.0496
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0029 0.0034 0.0034
Schistosoma mansoni lamin 0.0084 0.0192 0.0306
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Echinococcus granulosus serotonin transporter 0.0482 0.1342 0.1342
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0073 0.0161 0.0257
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0136 0.0342 0.0719
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0358 0.0985 0.1574
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0286 0.0457
Trichomonas vaginalis chromobox protein, putative 0.0139 0.035 0.0839
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.013 0.0274
Echinococcus granulosus neuropeptide s receptor 0.0358 0.0985 0.0985
Brugia malayi phosphofructokinase 0.0117 0.0286 0.0601
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Onchocerca volvulus 0.0358 0.0985 0.2362
Onchocerca volvulus 0.0076 0.0169 0.0403
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Onchocerca volvulus 0.0358 0.0985 0.2362
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0192 0.0306
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1243 0.3543 0.5658
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0269
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0044 0.0093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Schistosoma mansoni hypothetical protein 0.0076 0.0169 0.0269
Brugia malayi putative neuropeptide receptor NPR1 0.0358 0.0985 0.2069
Trichomonas vaginalis mercuric reductase, putative 0.005 0.0095 0.0227
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.0305 0.064
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0015 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0207 0.0548 0.0876
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0014 0.0014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0082 0.0185 0.0555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0035 0.0083
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0123 0.0305 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0358 0.0985 0.0985
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2417 0.694 0.694
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0236 0.0236
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0358 0.0985 0.1574
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Echinococcus granulosus glycine receptor subunit alpha 1 0.0136 0.0342 0.0342
Schistosoma mansoni opsin-like receptor 0.0358 0.0985 0.1574
Brugia malayi Trypsin family protein 0.0076 0.0169 0.0354
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0123 0.0305 0.064
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0066 0.0066
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0014 0.0022
Schistosoma mansoni biogenic amine receptor 0.0358 0.0985 0.1574
Loa Loa (eye worm) fli-1 protein 0.024 0.0642 0.1025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0077 0.0077
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0015 0.0031
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0062 0.0131
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Echinococcus granulosus lamin dm0 0.0084 0.0192 0.0192
Echinococcus multilocularis allatostatin A receptor 0.0358 0.0985 0.0985
Loa Loa (eye worm) thioredoxin reductase 0.0146 0.037 0.0591
Brugia malayi hypothetical protein 0.0023 0.0015 0.0031
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0269
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.004 0.0544
Schistosoma mansoni hypothetical protein 0.0033 0.0044 0.007
Giardia lamblia Alanyl dipeptidyl peptidase 0.0123 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.002 0.002
Toxoplasma gondii hypothetical protein 0.0082 0.0185 0.0555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0062 0.01
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0136 0.0342 0.0342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0099 0.0236 0.0377
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0056 0.0232
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0018 0.0039
Entamoeba histolytica prolyl oligopeptidase family protein 0.0123 0.0305 1
Echinococcus granulosus fmrfamide receptor 0.0358 0.0985 0.0985
Echinococcus granulosus hypothetical protein 0.1049 0.2983 0.2983
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.005 0.0095 0.2511
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0082 0.0185 0.9654
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0136 0.0342 0.0719
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Onchocerca volvulus 0.0076 0.0169 0.0403
Echinococcus granulosus enteropeptidase 0.0076 0.0169 0.0169
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0072 0.0072
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0062 0.0209
Brugia malayi Dopamine receptor protein 1 0.0761 0.215 0.4514
Echinococcus granulosus chromobox protein 1 0.0139 0.035 0.035
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0136 0.0342 0.0547
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Echinococcus multilocularis thioredoxin glutathione reductase 0.0146 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.005 0.0095 0.0318
Brugia malayi SET domain containing protein 0.003 0.0036 0.0076
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0082 0.0185 0.0296
Echinococcus multilocularis cpg binding protein 0.0033 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.2183 0.6261 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0082 0.0185 0.0296
Onchocerca volvulus 0.0082 0.0185 0.0443
Onchocerca volvulus 0.0358 0.0985 0.2362
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0136 0.0342 0.0719
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0358 0.0985 0.1574
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.014 0.0419
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0332 0.091 0.3047
Schistosoma mansoni neuropeptide F-like receptor 0.0358 0.0985 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0108 0.0258
Echinococcus multilocularis serotonin receptor 0.2183 0.6261 0.6261
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0082 0.0185 0.0296
Echinococcus multilocularis sodium and chloride dependent glycine 0.0082 0.0185 0.0185
Echinococcus multilocularis g-protein coupled receptor 0.0358 0.0985 0.0985
Toxoplasma gondii NADPH-glutathione reductase 0.005 0.0095 0.0284
Brugia malayi Dopamine receptor protein 2 0.0358 0.0985 0.2069
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0482 0.1342 0.2818
Loa Loa (eye worm) heterochromatin protein 1 0.0139 0.035 0.0559
Schistosoma mansoni hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0082 0.0185 0.0296
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0073 0.0161 0.0338
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0358 0.0985 0.0985
Echinococcus granulosus g protein coupled receptor 0.0358 0.0985 0.0985
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0332 0.091 0.3047
Schistosoma mansoni adenoreceptor 0.0358 0.0985 0.1574
Onchocerca volvulus 0.0084 0.0192 0.0459
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0062 0.1022
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0286 0.9365
Schistosoma mansoni neurotransmitter gated ion channel 0.0063 0.013 0.0208
Schistosoma mansoni ap endonuclease 0.0039 0.0062 0.0099
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0332 0.091 0.3047
Echinococcus multilocularis neuropeptide FF receptor 2 0.0358 0.0985 0.0985
Mycobacterium ulcerans hydrolase 0.0018 0 0.0002
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0 0.0002
Brugia malayi prolyl oligopeptidase family protein 0.0123 0.0305 0.064
Schistosoma mansoni hypothetical protein 0.0076 0.0169 0.0269
Echinococcus multilocularis transmembrane protease serine 3 0.0076 0.0169 0.0169
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0191 0.1468
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.01
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.0489 0.1172
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0025 0.0039
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0015 0.0031
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Echinococcus granulosus Chromobox protein 3 0.0023 0.0015 0.0015
Echinococcus multilocularis fmrfamide receptor 0.0358 0.0985 0.0985
Mycobacterium ulcerans flavoprotein disulfide reductase 0.005 0.0095 0.0394
Loa Loa (eye worm) hypothetical protein 0.1243 0.3543 0.5658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0062 0.2029
Echinococcus granulosus neuropeptides capa receptor 0.0358 0.0985 0.0985
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0063 0.013 0.013
Mycobacterium tuberculosis Possible hydrolase 0.0018 0 0.0001
Brugia malayi RE15519p 0.0358 0.0985 0.2069
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0056 0.0133
Echinococcus multilocularis g protein coupled receptor 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0022
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0136 0.0342 0.0547
Echinococcus granulosus neuropeptide Y receptor 0.0358 0.0985 0.0985
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0062 0.01
Loa Loa (eye worm) helicase 0.0023 0.0015 0.0023
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0088 0.0185
Schistosoma mansoni cercarial elastase (S01 family) 0.0076 0.0169 0.0269
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0467 0.1298 0.5386
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.005 0.0095 0.0394
Onchocerca volvulus 0.0358 0.0985 0.2362
Brugia malayi Ets-domain containing protein 0.0079 0.0177 0.0372
Onchocerca volvulus 0.0358 0.0985 0.2362
Loa Loa (eye worm) hypothetical protein 0.0658 0.1852 0.2958
Echinococcus granulosus neuropeptide receptor 0.0358 0.0985 0.0985
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0014 0.0014
Loa Loa (eye worm) LGC-31 protein 0.0136 0.0342 0.0547
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0015 0.0023
Schistosoma mansoni amine GPCR 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Onchocerca volvulus 0.0358 0.0985 0.2362
Loa Loa (eye worm) hypothetical protein 0.0082 0.0185 0.0296
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0062 0.0062
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0127 0.0427
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0062 0.1615
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0467 0.1298 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0269
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0012 0.0042
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0358 0.0985 0.0985
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.105 0.2986 1
Brugia malayi Trypsin family protein 0.0076 0.0169 0.0354
Brugia malayi neuropeptide F receptor 0.0358 0.0985 0.2069
Echinococcus granulosus 7TM GPCR rhodopsin 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.1243 0.3543 0.5658
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0136 0.0342 0.0547
Echinococcus granulosus glycine receptor subunit beta 0.0136 0.0342 0.0342
Echinococcus granulosus glycoprotein Antigen 5 0.0076 0.0169 0.0169
Echinococcus multilocularis Mastin 0.0076 0.0169 0.0169
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.005 0.0095 0.0394
Loa Loa (eye worm) hypothetical protein 0.2183 0.6261 1
Toxoplasma gondii endonuclease IV APN 0.0084 0.0191 0.057
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0286 0.0686
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0023
Plasmodium vivax SET domain protein, putative 0.0185 0.0483 1
Echinococcus granulosus chromobox protein 1 0.0139 0.035 0.035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0035 0.0083
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0123 0.0305 0.064
Echinococcus granulosus thioredoxin glutathione reductase 0.0146 0.037 0.037
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0029 0.0034 0.0072
Loa Loa (eye worm) hypothetical protein 0.0076 0.0169 0.0269
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.004 0.012
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Brugia malayi Tachykinin-like peptides receptor 99D 0.0358 0.0985 0.2069
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Echinococcus granulosus serotonin receptor 0.0358 0.0985 0.0985
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0062 0.1016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Schistosoma mansoni hypothetical protein 0.0693 0.1954 0.3121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0077 0.0077
Schistosoma mansoni cpg binding protein 0.0033 0.0045 0.0071
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0136 0.0342 0.0342
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0003 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.017 0.0406
Onchocerca volvulus 0.0023 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.1173 0.3342 0.5337
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0342 0.0719
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.01
Loa Loa (eye worm) hypothetical protein 0.0078 0.0174 0.0278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0062 0.0131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.0106
Echinococcus granulosus neuropeptide FF receptor 2 0.0358 0.0985 0.0985
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0062 0.0481
Brugia malayi AKH receptor 0.0358 0.0985 0.2069
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0136 0.0342 0.0719
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0062 0.0209
Mycobacterium ulcerans hypothetical protein 0.0076 0.0169 0.0699
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0072 0.0072
Echinococcus granulosus somatostatin receptor 0.0358 0.0985 0.0985
Schistosoma mansoni amine GPCR 0.0358 0.0985 0.1574
Schistosoma mansoni cpg binding protein 0.0033 0.0045 0.0071
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0095 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0286 0.0286
Echinococcus multilocularis orexin receptor type 2 0.0358 0.0985 0.0985
Trichomonas vaginalis glutathione reductase, putative 0.005 0.0095 0.0227
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0136 0.0342 0.0342
Echinococcus multilocularis neuropeptide receptor 0.0358 0.0985 0.0985
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0269
Echinococcus multilocularis voltage gated potassium channel 0.0029 0.0034 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0127 0.0529
Echinococcus multilocularis neuropeptide Y receptor 0.0358 0.0985 0.0985
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0174 0.0416
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0062 0.0131
Loa Loa (eye worm) hypothetical protein 0.0082 0.0185 0.0296
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0062 0.0131
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0025 0.0102
Brugia malayi excitatory GABA receptor EXP-1A 0.0136 0.0342 0.0719
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0079 0.0079
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0004
Onchocerca volvulus 0.0358 0.0985 0.2362
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0123 0.0305 0.073
Brugia malayi hypothetical protein 0.0063 0.013 0.0274
Echinococcus granulosus biogenic amine 5HT receptor 0.2183 0.6261 0.6261
Schistosoma mansoni gabp alpha 0.0079 0.0177 0.0283
Trypanosoma cruzi trypanothione reductase, putative 0.0146 0.037 0.0777
Brugia malayi hypothetical protein 0.0063 0.013 0.0274
Schistosoma mansoni acetylcholine receptor-related 0.0063 0.013 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0019 0.0456
Loa Loa (eye worm) hypothetical protein 0.0082 0.0185 0.0296
Toxoplasma gondii thioredoxin reductase 0.0146 0.037 0.1108
Plasmodium falciparum glutathione reductase 0.0146 0.037 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni hypothetical protein 0.0358 0.0985 0.1574
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0136 0.0342 0.0547
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.004 0.0095
Echinococcus multilocularis chromobox protein 2 0.0023 0.0015 0.0015
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0003 0.0003
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1173 0.3342 0.7017
Loa Loa (eye worm) hypothetical protein 0.0084 0.0191 0.0304
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.004 0.0095
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0026 0.006
Loa Loa (eye worm) hypothetical protein 0.0761 0.2149 0.3432
Loa Loa (eye worm) hypothetical protein 0.0018 0 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0024 0.0057
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.01
Schistosoma mansoni biogenic amine receptor 0.0358 0.0985 0.1574
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.013 0.0274
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0177 0.0177
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0123 0.0305 0.064
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.004 0.0878
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0014 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0185 0.0483 0.0771
Brugia malayi hypothetical protein 0.0063 0.013 0.0274
Brugia malayi larval opioid receptor 0.0358 0.0985 0.2069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0095 0.0199
Loa Loa (eye worm) hypothetical protein 0.0018 0 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0054 0.0086
Mycobacterium ulcerans beta-lactamase 0.0039 0.0062 0.0259
Brugia malayi prolyl oligopeptidase family protein 0.0123 0.0305 0.064
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Echinococcus granulosus nAChR subunit 0.0136 0.0342 0.0342
Echinococcus multilocularis expressed conserved protein 0.0093 0.0219 0.0219
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0063 0.013 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0023
Echinococcus multilocularis glycine receptor subunit beta 0.0136 0.0342 0.0342
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0062 0.017
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0015 0.00000000047282
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Brugia malayi 6-phosphofructokinase 0.0117 0.0286 0.0601
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0286 0.0686
Echinococcus granulosus glycine receptor subunit beta 0.0136 0.0342 0.0342
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0342 0.0719
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0062 0.0131
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0 0.0001
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0003 0.0005
Plasmodium falciparum transporter, putative 0.0082 0.0185 0.4972
Loa Loa (eye worm) hypothetical protein 0.0082 0.0185 0.0296
Mycobacterium ulcerans arylsulfatase AtsB 0.0018 0 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0082 0.0185 0.0296
Echinococcus multilocularis nAChR subunit 0.0136 0.0342 0.0342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.0985 0.1574
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0014 0.0032
Brugia malayi hypothetical protein 0.0063 0.013 0.0274
Schistosoma mansoni intermediate filament proteins 0.0084 0.0192 0.0306
Echinococcus multilocularis g protein coupled receptor 0.0358 0.0985 0.0985
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0035 0.0083
Echinococcus multilocularis neuropeptides capa receptor 0.0358 0.0985 0.0985
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0012 0.0029
Schistosoma mansoni neuropeptide receptor 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Schistosoma mansoni hypothetical protein 0.0053 0.0101 0.0161
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0095 0.0199
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0012 0.0026
Mycobacterium leprae Probable lipase LipE 0.0039 0.0062 0.0481
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.005 0.0095 0.0199
Trypanosoma brucei trypanothione reductase 0.0146 0.037 0.0777
Onchocerca volvulus 0.0076 0.0169 0.0403
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0056 0.0133
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0358 0.0985 0.1574
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0035 0.0083
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0136 0.0342 0.0342
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0082 0.0185 0.0389
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0014 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0025 0.0052
Brugia malayi glutaminase DH11.1 0.0851 0.241 0.5061
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0062 0.0209
Echinococcus granulosus Dipeptidyl peptidase 9 0.0123 0.0305 0.0305
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0286 0.0959
Echinococcus granulosus microtubule associated protein 2 0.0752 0.2125 0.2125
Echinococcus granulosus Mastin 0.0076 0.0169 0.0169
Chlamydia trachomatis endonuclease IV 0.0084 0.0191 1
Entamoeba histolytica hypothetical protein, conserved 0.0123 0.0305 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0095 0.0199
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0062 0.0208
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0136 0.0342 0.0342
Treponema pallidum sodium- and chloride- dependent transporter 0.0482 0.1342 1
Loa Loa (eye worm) G-protein coupled receptor 0.0358 0.0985 0.1574
Plasmodium falciparum thioredoxin reductase 0.0146 0.037 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0467 0.1298 0.2726
Schistosoma mansoni lamin 0.0084 0.0192 0.0306
Echinococcus multilocularis g protein coupled receptor 0.0358 0.0985 0.0985
Brugia malayi Dopamine receptor 0.0358 0.0985 0.2069
Echinococcus granulosus glycine receptor subunit alpha 1 0.0136 0.0342 0.0342
Echinococcus granulosus chromobox protein 2 0.0023 0.0015 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0286 0.0686
Schistosoma mansoni amine GPCR 0.0856 0.2424 0.3871
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0084
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0063 0.013 0.0274
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0076 0.0169 0.0169
Mycobacterium ulcerans lipase LipD 0.0039 0.0062 0.0259
Loa Loa (eye worm) hypothetical protein 0.0033 0.0044 0.007
Onchocerca volvulus 0.0482 0.1342 0.3216
Loa Loa (eye worm) hypothetical protein 0.0076 0.0169 0.0269
Mycobacterium ulcerans arylsulfatase, AslA 0.0018 0 0.0002
Loa Loa (eye worm) solute carrier family 6 member 4 0.0482 0.1342 0.2143
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0286 0.0686
Schistosoma mansoni amine GPCR 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0073 0.0161 0.0257
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.01
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1283 0.3659 0.5843
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Echinococcus multilocularis microtubule associated protein 2 0.0752 0.2125 0.2125
Echinococcus granulosus intermediate filament protein 0.0084 0.0192 0.0192
Onchocerca volvulus 0.0358 0.0985 0.2362
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0014 0.0014
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0136 0.0342 0.0342
Toxoplasma gondii ABC1 family protein 0.0039 0.0062 0.0187
Mycobacterium ulcerans sulfatase 0.0018 0 0.0002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0174 0.0416
Echinococcus granulosus alpha 1A adrenergic receptor 0.0358 0.0985 0.0985
Brugia malayi hypothetical protein 0.0358 0.0985 0.2069
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0056 0.0117
Echinococcus multilocularis geminin 0.0693 0.1954 0.1954
Schistosoma mansoni neuropeptide F-like receptor 0.0358 0.0985 0.1574
Loa Loa (eye worm) hypothetical protein 0.0123 0.0305 0.0487
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0286 0.0601
Echinococcus multilocularis nAChR subunit 0.0073 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0071 0.0153 0.0245
Echinococcus granulosus Chromo domain 0.0023 0.0015 0.0015
Schistosoma mansoni sodium/chloride dependent transporter 0.0082 0.0185 0.0296
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0079 0.0188
Loa Loa (eye worm) RecQ helicase 0.0045 0.0079 0.0126
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0123 0.0305 0.0487
Leishmania major C-8 sterol isomerase-like protein 0.1664 0.4762 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0286 0.2206
Brugia malayi Heterochromatin protein 1 0.0139 0.035 0.0736
Onchocerca volvulus 0.0358 0.0985 0.2362
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0015 0.0034
Brugia malayi ORL1-like opioid receptor 0.0358 0.0985 0.2069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Brugia malayi Pre-SET motif family protein 0.1283 0.3659 0.7683
Brugia malayi Serotonin receptor 0.0358 0.0985 0.2069
Trichomonas vaginalis chromobox protein, putative 0.0139 0.035 0.0839
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0018 0.0039
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0123 0.0305 0.073
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0063 0.013 0.013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0088 0.0141
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0358 0.0985 0.1574
Plasmodium vivax hypothetical protein, conserved 0.0123 0.0305 0.6199
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0034
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0358 0.0985 0.2069
Echinococcus granulosus dnaJ subfamily B 0.0446 0.1238 0.1238
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1664 0.4762 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.0985 0.0985
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0015 0.00000000076279
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0812 0.2298 0.3671
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0108 0.0258
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0136 0.0342 0.0719
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0015 0.0327
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0076 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0136 0.0342 0.0547
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0073 0.0161 0.0338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0077 0.0123
Plasmodium falciparum glutathione reductase 0.005 0.0095 0.2511
Echinococcus multilocularis serotonin transporter 0.0482 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0358 0.0985 0.1574
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0034 0.0055
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0063 0.013 0.0208
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0169 0.0269

Activities

Activity type Activity value Assay description Source Reference
KA (binding) = 131 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase II (hCA II) ChEMBL. 11934582
KA (binding) = 131 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase II (hCA II) ChEMBL. 11934582
KA (binding) > 200 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase I (hCA I) ChEMBL. 11934582
KA (binding) > 200 uM Tested in vitro for activation of carbonic anhydrase IV (bCA IV), purified from bovine lung microsomes ChEMBL. 11934582
KA (binding) > 200 uM Tested in vitro for activation of Human cloned isozyme carbonic anhydrase I (hCA I) ChEMBL. 11934582
KA (binding) > 200 uM Tested in vitro for activation of carbonic anhydrase IV (bCA IV), purified from bovine lung microsomes ChEMBL. 11934582

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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