Detailed information for compound 1927484

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 273.277 | Formula: C16H13F2NO
  • H donors: 1 H acceptors: 1 LogP: 3.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)[C@H]1C[C@@H]1c1cccc(c1)F
  • InChi: 1S/C16H13F2NO/c17-11-4-6-13(7-5-11)19-16(20)15-9-14(15)10-2-1-3-12(18)8-10/h1-8,14-15H,9H2,(H,19,20)/t14-,15+/m1/s1
  • InChiKey: BRAZDVBIMMNBLE-CABCVRRESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase CWC27 0.0014 0.0439 0.0439
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0025 0.0025
Leishmania major cyclophilin 7, putative 0.0014 0.0439 1
Loa Loa (eye worm) cyclophilin Ovcyp-2 0.0014 0.0439 0.0439
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-15 0.0014 0.0439 0.0439
Brugia malayi hypothetical protein 0.0062 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-16 0.0014 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0025 0.0025
Mycobacterium leprae Probable peptidyl-prolyl cis-trans isomerase PpiA (PPIase A) (Rotamase A) 0.0014 0.0439 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0025 0.0025
Echinococcus granulosus peptidyl prolyl cis trans isomerase 3 0.0014 0.0439 0.0439
Onchocerca volvulus 0.0014 0.0439 0.0414
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0042 0.6098 0.6098
Echinococcus multilocularis follistatin 0.0042 0.6098 0.6098
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase B 0.0014 0.0439 0.0439
Toxoplasma gondii peptidyl-prolyl isomerase 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Onchocerca volvulus 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.6098 0.6098
Loa Loa (eye worm) hypothetical protein 0.0042 0.6098 0.6098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0439 0.0439
Trichomonas vaginalis cyclophilin, putative 0.0014 0.0439 1
Mycobacterium ulcerans peptidyl-prolyl cis-trans isomerase B PpiB 0.0014 0.0439 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0439 0.0439
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 2 ppil2 0.0014 0.0439 0.0414
Brugia malayi SPARC precursor 0.0042 0.6098 0.6088
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Onchocerca volvulus Putative organic anion transporter 0.0062 1 1
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase B precursor, putative 0.0014 0.0439 1
Plasmodium vivax cyclophilin, putative 0.0014 0.0439 1
Schistosoma mansoni cyclophilin E 0.0014 0.0439 0.0414
Leishmania major cyclophilin 6, putative 0.0014 0.0439 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0062 1 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0062 1 1
Schistosoma mansoni agrin 0.0042 0.6098 0.6088
Echinococcus granulosus follistatin 0.0042 0.6098 0.6098
Leishmania major cyclophilin a 0.0014 0.0439 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-13, Bmcyp-13 0.0014 0.0439 0.0414
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Brugia malayi secreted modular calcium-binding protein 1 0.0042 0.6098 0.6088
Trypanosoma brucei RNA-binding protein, putative 0.0014 0.0439 0.5
Plasmodium vivax cyclophilin, putative 0.0014 0.0439 1
Echinococcus multilocularis protein S isoprenylcysteine O methyltransferase 0.0014 0.0439 0.0439
Echinococcus granulosus peptidyl prolyl cis trans isomerase 6 0.0014 0.0439 0.0439
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 6 0.0014 0.0439 0.0439
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 2 0.0014 0.0439 0.0439
Echinococcus multilocularis peptidyl prolyl isomerase G 0.0014 0.0439 0.0439
Giardia lamblia Peptidyl-prolyl cis-trans isomerase B precursor 0.0014 0.0439 0.5
Toxoplasma gondii cyclophilin 0.0014 0.0439 0.0414
Plasmodium vivax cyclophilin, putative 0.0014 0.0439 1
Plasmodium vivax cyclophilin, putative 0.0014 0.0439 1
Schistosoma mansoni follistatin 0.0042 0.6098 0.6088
Leishmania major cyclophilin 14, putative 0.0014 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0439 0.0439
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase h ppih 0.0014 0.0439 0.0414
Brugia malayi peptidyl-prolyl cis-trans isomerase, cyclophilin-type family protein 0.0014 0.0439 0.0414
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase (cyclophilin) 0.0014 0.0439 0.0414
Brugia malayi peptidyl-prolyl cis-trans isomerase 11 0.0014 0.0439 0.0414
Toxoplasma gondii protease inhibitor PI2 0.0042 0.6098 0.6088
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0025 0.0025
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-2, Bmcyp-2 0.0014 0.0439 0.0414
Trichomonas vaginalis cyclophilin, putative 0.0014 0.0439 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0025 0.0025
Echinococcus multilocularis expressed protein 0.0014 0.0439 0.0439
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0062 1 1
Schistosoma mansoni organic anion transporter 0.0062 1 1
Leishmania major cyclosporin 16, putative 0.0014 0.0439 1
Loa Loa (eye worm) peptidyl-prolyl cis-trans isomerase 11 0.0014 0.0439 0.0439
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-16, Bmcyp-16 0.0014 0.0439 0.0414
Treponema pallidum peptidyl-prolyl cis-trans isomerase, cyclophilin-binding (cyp) 0.0014 0.0439 0.5
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Mycobacterium tuberculosis Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) 0.0014 0.0439 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Toxoplasma gondii cyclophilin, putative 0.0014 0.0439 0.0414
Loa Loa (eye worm) cyclophilin 0.0014 0.0439 0.0439
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Echinococcus granulosus U snRNP-associated cyclophilin protein 0.0014 0.0439 0.0439
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmcyp-15 0.0014 0.0439 0.0414
Leishmania major cyclophilin 5, putative 0.0014 0.0439 1
Toxoplasma gondii cyclophilin, putative 0.0014 0.0439 0.0414
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0025
Leishmania major cyclophilin 4, putative 0.0014 0.0439 1
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0439 0.0439
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0025 0.0025
Toxoplasma gondii cyclophilin, putative 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin, putative 0.0014 0.0439 0.5
Schistosoma mansoni cyclophilin B 0.0014 0.0439 0.0414
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.6098 0.6088
Leishmania major cyclophilin 2 0.0014 0.0439 1
Plasmodium vivax cyclophilin, putative 0.0014 0.0439 1
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Loa Loa (eye worm) SIG-7 protein 0.0014 0.0439 0.0439
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Trypanosoma cruzi MFS transporter, putative 0.0062 1 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, cyclophilin-type domain-containing protein 0.0014 0.0439 0.0414
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-3, Bmcyp-3 0.0014 0.0439 0.0414
Plasmodium vivax unspecified product 0.0014 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.6098 0.6098
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Schistosoma mansoni cyclophilin 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Leishmania major cyclophilin 8, putative 0.0014 0.0439 1
Leishmania major cyclophilin 40 0.0014 0.0439 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase B 0.0014 0.0439 0.0439
Echinococcus granulosus peptidyl prolyl cis trans isomerase 2 0.0014 0.0439 0.0439
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, cyclophilin-type domain-containing protein 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Trichomonas vaginalis cyclophilin, putative 0.0014 0.0439 1
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0025 0.0025
Echinococcus multilocularis expressed protein 0.0042 0.6098 0.6098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0025
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0012 0.0025 0.0025
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.6098 0.6088
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Echinococcus multilocularis U snRNP-associated cyclophilin protein 0.0014 0.0439 0.0439
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Leishmania major cyclophilin 13, putative 0.0014 0.0439 1
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase D, ppid, putative 0.0014 0.0439 1
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-18 0.0014 0.0439 0.0439
Echinococcus granulosus peptidyl prolyl cis trans isomerase CWC27 0.0014 0.0439 0.0439
Echinococcus granulosus peptidyl prolyl cis trans isomerase E 0.0014 0.0439 0.0439
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin a 0.0014 0.0439 0.5
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 0.0414
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase G ppig 0.0014 0.0439 0.0414
Brugia malayi sodium-independent organic anion transporter family protein 0.0062 1 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-6, Bmcyp-6 0.0014 0.0439 0.0414
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-2 0.0014 0.0439 0.0439
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Echinococcus granulosus Solute carrier organic anion transporter family 0.0062 1 1
Echinococcus granulosus peptidyl prolyl isomerase G 0.0014 0.0439 0.0439
Mycobacterium tuberculosis Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase) 0.0014 0.0439 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0012 0.0025 0.0025
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-12, Bmcyp-12 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0025 0.0025
Giardia lamblia Peptidyl-prolyl cis-trans isomerase B precursor 0.0014 0.0439 0.5
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.6098 0.6088
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Trichomonas vaginalis cyclophillin, putative 0.0014 0.0439 1
Toxoplasma gondii cyclophilin precursor 0.0014 0.0439 0.0414
Echinococcus granulosus expressed protein 0.0014 0.0439 0.0439
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 4 0.0014 0.0439 0.0439
Echinococcus multilocularis peptidyl prolyl cis trans isomerase E 0.0014 0.0439 0.0439
Loa Loa (eye worm) CYN-5 protein 0.0014 0.0439 0.0439
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0025 0.0025
Onchocerca volvulus 0.0014 0.0439 0.0414
Entamoeba histolytica peptidyl prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Toxoplasma gondii U-snRNP-associated cyclophilin family protein 0.0014 0.0439 0.0414
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative 0.0014 0.0439 0.5
Loa Loa (eye worm) cytosolic cyclophilin 0.0014 0.0439 0.0439
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0025 0.0025
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0025 0.0025
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase family 1 0.0014 0.0439 0.0414
Leishmania major cyclophilin 12, putative 0.0014 0.0439 1
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 0.0414
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.6098 0.6088
Onchocerca volvulus 0.0062 1 1
Toxoplasma gondii transporter, major facilitator family protein 0.0062 1 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0012 0.0025 0.5
Schistosoma mansoni organic anion transporter 0.0062 1 1
Plasmodium vivax cyclophilin, putative 0.0014 0.0439 1
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0025 0.0025
Toxoplasma gondii peptidylprolyl isomerase domain-containing protein 0.0014 0.0439 0.0414
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.6098 0.6088
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 1 0.0014 0.0439 0.0439
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase A, ppia, putative 0.0014 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Leishmania major cyclophilin 9, putative 0.0014 0.0439 1
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmcyp-5 0.0014 0.0439 0.0414
Loa Loa (eye worm) hypothetical protein 0.0014 0.0439 0.0439
Onchocerca volvulus 0.0014 0.0439 0.0414
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.6098 0.6088
Echinococcus multilocularis peptidyl prolyl cis trans isomerase 4 0.0014 0.0439 0.0439
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 1 ppil1 0.0014 0.0439 0.0414
Trypanosoma brucei cyclophilin 15, putative 0.0014 0.0439 0.5
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase-like 1 ppil1 0.0014 0.0439 0.0414
Plasmodium vivax cyclophilin, putative 0.0014 0.0439 1
Onchocerca volvulus 0.0062 1 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.6098 0.6088
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Toxoplasma gondii cyclophilin 1, putative 0.0014 0.0439 0.0414
Schistosoma mansoni cyclophilin 0.0014 0.0439 0.0414
Echinococcus granulosus peptidyl prolyl cis trans isomerase 1 0.0014 0.0439 0.0439
Mycobacterium ulcerans peptidyl-prolyl cis-trans isomerase A, PpiA 0.0014 0.0439 0.5
Echinococcus multilocularis peptidylprolyl isomerase domain and WD40 repeat 0.0014 0.0439 0.0439
Brugia malayi sodium-independent organic anion transporter family protein 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.6098 0.6098
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase A, ppia, putative 0.0014 0.0439 1
Mycobacterium leprae Probable peptidyl-prolyl cis-trans isomerase B PpiB (Cyclopphilin) (Ppiase) (Rotamase) (Peptidylprolyl isomerase) 0.0014 0.0439 0.5
Loa Loa (eye worm) agrin synaptic family protein 0.0042 0.6098 0.6098
Echinococcus granulosus peptidylprolyl isomerase domain and WD40 repeat 0.0014 0.0439 0.0439
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0025 0.0025
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0062 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0025 0.0025
Echinococcus granulosus agrin 0.0042 0.6098 0.6098
Leishmania major cyclophilin 3, putative 0.0014 0.0439 1
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Echinococcus multilocularis agrin 0.0042 0.6098 0.6098
Plasmodium vivax peptidyl-prolyl cis-trans isomerase 11, putative 0.0014 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Onchocerca volvulus 0.0062 1 1
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 1
Onchocerca volvulus 0.0062 1 1
Onchocerca volvulus Putative organic anion transporter 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.6098 0.6088
Leishmania major cyclophilin 10, putative 0.0014 0.0439 1
Schistosoma mansoni peptidyl-prolyl cis-trans isomerase G ppig 0.0014 0.0439 0.0414
Onchocerca volvulus 0.0042 0.6098 0.6088
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-18, Bmcyp-18 0.0014 0.0439 0.0414
Brugia malayi hypothetical protein 0.0062 1 1
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-4, Bmcyp-4 0.0014 0.0439 0.0414
Trypanosoma brucei Peptidyl-prolyl cis-trans isomerase C, mitochondrial, putative 0.0014 0.0439 0.5
Trypanosoma brucei cyclophilin type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0014 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Trypanosoma brucei cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative 0.0014 0.0439 0.5
Leishmania major cyclophilin 11, putative 0.0014 0.0439 1
Onchocerca volvulus Putative organic anion transporter 0.0062 1 1
Trypanosoma brucei cyclophilin, putative 0.0014 0.0439 0.5
Brugia malayi prostaglandin transporter 0.0062 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 160 uM Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess assay ChEMBL. 25937015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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