Detailed information for compound 1959600

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.49 | Formula: C24H25F3N6O2
  • H donors: 1 H acceptors: 4 LogP: 4.04 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(c1c(C)nn(c1C)C)C)COc1nc2n(C)nc(c2c(c1)C(F)(F)F)c1ccccc1
  • InChi: 1S/C24H25F3N6O2/c1-13(20-14(2)30-32(4)15(20)3)28-18(34)12-35-19-11-17(24(25,26)27)21-22(16-9-7-6-8-10-16)31-33(5)23(21)29-19/h6-11,13H,12H2,1-5H3,(H,28,34)
  • InChiKey: VZJOTTKLMKQRID-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hypocretin (orexin) receptor 1 Starlite/ChEMBL No references
Homo sapiens hypocretin (orexin) receptor 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis G protein coupled receptor 139 Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma mansoni neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Get druggable targets OG5_127863 All targets in OG5_127863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus sex peptide receptor hypocretin (orexin) receptor 1 425 aa 350 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0238 0.0183
Leishmania major hypothetical protein, conserved 0.0031 0.0238 0.2422
Trypanosoma cruzi ion transport protein, putative 0.0031 0.0238 0.2422
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0102 0.0046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0052 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.111 0.1101
Onchocerca volvulus 0.0077 0.0839 0.082
Brugia malayi glutaminase DH11.1 0.0194 0.2374 0.2708
Loa Loa (eye worm) voltage-dependent calcium channel 0.0036 0.0301 0.0283
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0029 0.0212 0.0194
Mycobacterium ulcerans lipase LipD 0.003 0.0223 0.0763
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0456 0.5821 0.5861
Brugia malayi larval opioid receptor 0.0015 0.0021 0.0024
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0046 0.0025
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0301 0.0283
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0223 0.0205
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0092 0.1041 0.1031
Echinococcus granulosus geminin 0.0433 0.5508 0.5545
Trypanosoma brucei trypanothione reductase 0.0051 0.0503 0.5755
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0456 0.5821 0.5861
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0503 0.0488
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0031 0.0238 0.022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0212 0.0242
Trypanosoma cruzi ion transport protein, putative 0.0031 0.0238 0.2422
Leishmania major DNA polymerase eta, putative 0.0017 0.0056 0.0129
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0056 0.0064
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0052 0.0032
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0062 0.0071
Onchocerca volvulus 0.0184 0.2238 0.2222
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0031 0.0238 0.022
Loa Loa (eye worm) hypothetical protein 0.0768 0.9917 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0133 0.1575 0.1797
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0062 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0223 0.0168
Schistosoma mansoni calcium-activated potassium channel 0.0031 0.0238 0.022
Schistosoma mansoni neurotransmitter gated ion channel 0.0034 0.0277 0.0259
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0036 0.0301 0.0343
Onchocerca volvulus Putative nachr subunit 0.0184 0.2238 0.2222
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0031 0.0238 0.022
Brugia malayi hypothetical protein 0.0021 0.0102 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0082
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0212 0.0194
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0052 0.0032
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Plasmodium vivax potassium channel, putative 0.0031 0.0238 0.1761
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0062 0.0095
Treponema pallidum fructose-bisphosphate aldolase 0.0207 0.255 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0031 0.0238 0.0272
Trypanosoma brucei calcium-activated potassium channel, putative 0.0031 0.0238 0.2422
Loa Loa (eye worm) glutaminase 0.0194 0.2374 0.2378
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0102 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Echinococcus multilocularis glycine receptor subunit beta 0.0063 0.0661 0.0647
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0223 0.0168
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0216 0.0161
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0077 0.0841 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1369 0.5731
Schistosoma mansoni alpha-glucosidase 0.0115 0.1332 0.1325
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0092 0.1041 0.1031
Entamoeba histolytica hypothetical protein 0.0034 0.0277 0.0886
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0034 0.0277 0.0316
Toxoplasma gondii ion channel protein 0.0031 0.0238 0.181
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0056 0.0129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Brugia malayi Dopamine receptor protein 1 0.0015 0.0021 0.0024
Brugia malayi jmjC domain containing protein 0.0017 0.0052 0.0059
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0238 0.0183
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0102 0.0082
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Schistosoma mansoni acetylcholine receptor subunit beta 0.0029 0.0212 0.0194
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0029 0.0212 0.0194
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0503 0.0488
Onchocerca volvulus 0.0034 0.0277 0.0257
Brugia malayi Cation transporter family protein 0.0063 0.0661 0.0755
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0102 0.0082
Schistosoma mansoni nAChR subunit 0.0029 0.0212 0.0194
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0056 0.0129
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0102 0.0082
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0102 0.0082
Brugia malayi Cytochrome P450 family protein 0.0017 0.0046 0.0052
Echinococcus multilocularis dna polymerase eta 0.0017 0.0056 0.0036
Schistosoma mansoni nAChR subunit 0.0029 0.0212 0.0194
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0102 0.0082
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0062 0.0042
Brugia malayi hypothetical protein 0.0253 0.3147 0.359
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0062 0.0205
Loa Loa (eye worm) TWK-7 protein 0.0031 0.0238 0.022
Brugia malayi hypothetical protein 0.0029 0.0212 0.0242
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0681 0.8765 0.8836
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0063 0.0661 0.0755
Brugia malayi Melatonin receptor type 1A 0.0015 0.0021 0.0024
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0301 0.0283
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0046 0.0025
Entamoeba histolytica acetyltransferase, GNAT family 0.0025 0.0155 0.0397
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0034 0.0277 0.0316
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0052 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0335 0.0317
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0212 0.0242
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0841 0.0789
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0102 0.0082
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0661 0.0755
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0031 0.0238 0.0272
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0063 0.0661 0.0647
Mycobacterium ulcerans ion transport protein 0.0031 0.0238 0.0827
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0503 0.0488
Echinococcus multilocularis 0.0017 0.0046 0.0025
Echinococcus granulosus potassium channel subfamily K 0.0031 0.0238 0.022
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.1007 0.0996
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.0277 0.0259
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.0283
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0102 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0223 0.0168
Loa Loa (eye worm) hypothetical protein 0.0288 0.3615 0.3632
Trichomonas vaginalis glutaminase, putative 0.0194 0.2374 0.2331
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0238 0.0183
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0102 0.0082
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0062 0.0071
Brugia malayi RE15519p 0.0015 0.0021 0.0024
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0102 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0775 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0216 0.0246
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0133 0.1575 0.1571
Schistosoma mansoni nAChR subunit 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Brugia malayi cytochrome P450 0.0017 0.0046 0.0052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0094 0.1063 0.1053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0668 0.0654
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0841 0.0789
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0052 0.0079
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0102 0.0082
Schistosoma mansoni kinase 0.0039 0.0343 0.0326
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0207 0.255 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0661 0.0755
Loa Loa (eye worm) hypothetical protein 0.0032 0.0244 0.0225
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Schistosoma mansoni acetylcholine receptor-related 0.0029 0.0212 0.0194
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.1541 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0105 0.0085
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0063 0.0661 0.0647
Onchocerca volvulus 0.003 0.0223 0.0203
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0101 0.1158 0.4776
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0062 0.0042
Schistosoma mansoni hypothetical protein 0.0433 0.5508 0.5545
Schistosoma mansoni calcium-activated potassium channel 0.061 0.7834 0.7896
Mycobacterium tuberculosis Probable reductase 0.0117 0.1369 0.5731
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0184 0.2238 0.2241
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.033 0.0275
Brugia malayi excitatory GABA receptor EXP-1A 0.0063 0.0661 0.0755
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0056 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Echinococcus multilocularis lysosomal alpha glucosidase 0.0133 0.1575 0.1571
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0841 0.0829
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.0661 0.0647
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0335 0.124
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Leishmania major alpha glucosidase II subunit, putative 0.003 0.0216 0.2137
Entamoeba histolytica hypothetical protein 0.0021 0.0102 0.0184
Onchocerca volvulus 0.0098 0.111 0.1091
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0062 0.0153
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0036 0.0301 0.0283
Brugia malayi sulfakinin receptor protein 0.0015 0.0021 0.0024
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.0661 0.0647
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1541 0.6476
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0056 0.0036
Brugia malayi serine/threonine-protein kinase plk-2 0.0077 0.0841 0.096
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0841 0.0789
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Brugia malayi AKH receptor 0.0015 0.0021 0.0024
Brugia malayi jmjC domain containing protein 0.0017 0.0052 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0027 0.0185 0.0166
Brugia malayi Thioredoxin reductase 0.0051 0.0503 0.0574
Brugia malayi glutathione reductase 0.0051 0.0503 0.0574
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0062 0.0222
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0056 0.0064
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0102 0.0116
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0063 0.0661 0.0647
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0661 0.0755
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Schistosoma mansoni nAChR subunit 0.0063 0.0661 0.0647
Brugia malayi jmjC domain containing protein 0.0017 0.0052 0.0059
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1369 0.5731
Echinococcus granulosus glycine receptor subunit beta 0.0063 0.0661 0.0647
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0223 0.0255
Trypanosoma cruzi polo-like protein kinase, putative 0.0077 0.0841 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0301 0.0283
Echinococcus granulosus calcium activated potassium channel variant 0.0031 0.0238 0.022
Entamoeba histolytica serine/threonine protein kinase, putative 0.0077 0.0841 0.3148
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0661 0.0755
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0031 0.0238 0.0731
Onchocerca volvulus 0.0031 0.0238 0.0218
Brugia malayi neuropeptide F receptor 0.0015 0.0021 0.0024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1369 0.5731
Schistosoma mansoni glutaminase 0.0194 0.2374 0.2378
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0127 0.15 0.1495
Loa Loa (eye worm) hypothetical protein 0.0321 0.4048 0.4069
Echinococcus granulosus lysosomal alpha glucosidase 0.0133 0.1575 0.1571
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Plasmodium falciparum potassium channel 0.0031 0.0238 0.4128
Echinococcus multilocularis lysosomal alpha glucosidase 0.0133 0.1575 0.1571
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0238 0.0183
Schistosoma mansoni microtubule-associated protein tau 0.0489 0.6254 0.6299
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0301 0.0283
Onchocerca volvulus 0.0029 0.0212 0.0192
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0063 0.0661 0.0647
Leishmania major potassium channel subunit-like protein 0.0031 0.0238 0.2422
Echinococcus multilocularis potassium channel subfamily K 8 0.0031 0.0238 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Brugia malayi hypothetical protein 0.0029 0.0212 0.0242
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.0661 0.0647
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0184 0.2238 0.2241
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0184 0.2238 0.2554
Plasmodium vivax hypothetical protein, conserved 0.003 0.0223 0.162
Echinococcus granulosus nAChR subunit 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0102 0.0082
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0062 0.0042
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0668 0.0654
Echinococcus granulosus biogenic amine 5HT receptor 0.0456 0.5821 0.5861
Loa Loa (eye worm) acetylcholine receptor protein 0.0029 0.0212 0.0194
Loa Loa (eye worm) hypothetical protein 0.0022 0.0117 0.0097
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0056 0.0036
Brugia malayi Dopamine receptor protein 2 0.0015 0.0021 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Onchocerca volvulus 0.0029 0.0212 0.0192
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0223 0.077
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0056 0.0036
Mycobacterium ulcerans hypothetical protein 0.003 0.0223 0.0763
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.1541 0.6476
Echinococcus granulosus small conductance calcium activated potassium 0.0768 0.9917 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0036 0.0301 0.0283
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0102 0.0046
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0223 0.077
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0503 0.1983
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0031 0.0238 0.0272
Brugia malayi putative neuropeptide receptor 0.0015 0.0021 0.0024
Brugia malayi Cytochrome P450 family protein 0.0017 0.0046 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0205
Onchocerca volvulus 0.0031 0.0238 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0105 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0102 0.0046
Echinococcus granulosus twik family of potassium channels 0.0031 0.0238 0.022
Plasmodium falciparum potassium channel 0.0031 0.0238 0.4128
Trypanosoma brucei glucosidase, putative 0.003 0.0216 0.2137
Loa Loa (eye worm) hypothetical protein 0.0154 0.1854 0.1852
Onchocerca volvulus 0.0034 0.0277 0.0257
Loa Loa (eye worm) acetyltransferase 0.0092 0.1041 0.1031
Loa Loa (eye worm) hypothetical protein 0.0345 0.4359 0.4384
Leishmania major hypothetical protein, conserved 0.0017 0.0052 0.0079
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0102 0.0082
Schistosoma mansoni nAChR subunit 0.0063 0.0661 0.0647
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.3306 0.332
Mycobacterium ulcerans transmembrane cation transporter 0.0031 0.0238 0.0827
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Brugia malayi Cation transporter family protein 0.0184 0.2238 0.2554
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Toxoplasma gondii hypothetical protein 0.0032 0.0244 0.186
Loa Loa (eye worm) hypothetical protein 0.0098 0.111 0.1101
Onchocerca volvulus 0.0184 0.2238 0.2222
Brugia malayi hypothetical protein 0.0031 0.0238 0.0272
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0077 0.0841 0.0829
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Brugia malayi Serotonin receptor 0.0015 0.0021 0.0024
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0102 0.0082
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0216 0.0161
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0062 0.007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0056 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Brugia malayi beta-lactamase family protein 0.003 0.0223 0.0255
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0052 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0031 0.0238 0.0272
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0102 0.0082
Schistosoma mansoni hypothetical protein 0.0768 0.9917 1
Toxoplasma gondii thioredoxin reductase 0.0051 0.0503 0.43
Schistosoma mansoni calcium-activated potassium channel 0.0768 0.9917 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0223 0.0763
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0223 0.0205
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0056 0.0036
Onchocerca volvulus Serine\/threonine kinase homolog 0.0077 0.0841 0.0822
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0216 0.064
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0031 0.0238 0.0272
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1369 0.5731
Echinococcus multilocularis glycine receptor subunit beta 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0031 0.0238 0.0272
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.0661 0.0647
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0223 0.0205
Giardia lamblia Hypothetical protein 0.0031 0.0238 0.0731
Trypanosoma brucei unspecified product 0.0017 0.0056 0.0129
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0503 0.4267
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0102 0.0046
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0062 0.0205
Brugia malayi Serotonin receptor 0.0015 0.0021 0.0024
Schistosoma mansoni DNA polymerase eta 0.0017 0.0056 0.0036
Brugia malayi beta-lactamase 0.003 0.0223 0.0255
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0102 0.0082
Mycobacterium ulcerans beta-lactamase 0.003 0.0223 0.0763
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.0283
Entamoeba histolytica hypothetical protein 0.0021 0.0102 0.0184
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Brugia malayi ORL1-like opioid receptor 0.0015 0.0021 0.0024
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0021 0.0024
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0184 0.2238 0.2241
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0062 0.0205
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0063 0.0661 0.0647
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0029 0.0212 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0031 0.0238 0.022
Echinococcus granulosus neuropeptide receptor 0.0138 0.1642 0.1638
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0032
Loa Loa (eye worm) hypothetical protein 0.0253 0.3147 0.3159
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0062 0.0205
Echinococcus multilocularis nAChR subunit 0.0034 0.0277 0.0259
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0212 0.0194
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0021 0.0024
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0212 0.0242
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0063 0.0661 0.0755
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0027 0.0185 0.0129
Schistosoma mansoni cytochrome P450 0.0017 0.0046 0.0025
Schistosoma mansoni hypothetical protein 0.0433 0.5508 0.5545
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0056 0.0129
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0052 0.0032
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0102 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Schistosoma mansoni alpha glucosidase 0.003 0.0216 0.0197
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0661 0.0647
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0056 0.0044
Loa Loa (eye worm) hypothetical protein 0.0184 0.2238 0.2241
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0216 0.0161
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0029 0.0212 0.0242
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0668 0.0654
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.111 0.1101
Echinococcus granulosus phd:f box containing protein 0.0017 0.0052 0.0032
Leishmania major hypothetical protein, conserved 0.003 0.0223 0.2234
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0062 0.007
Brugia malayi jmjC domain containing protein 0.0064 0.0668 0.0762
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0031 0.0238 0.0272
Brugia malayi Dopamine receptor 0.0015 0.0021 0.0024
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.0184 0.2238 0.2241
Onchocerca volvulus 0.0184 0.2238 0.2222
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0077 0.0841 0.0829
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0052 0.0059
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0056 0.0036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0062 0.5
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0062 0.0205
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0027 0.0185 0.1305
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0101 0.1158 0.7438
Loa Loa (eye worm) glutathione reductase 0.0051 0.0503 0.0488
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0102 0.0082
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0021 0.0024
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0031 0.0238 0.0272
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Brugia malayi Pre-SET motif family protein 0.0681 0.8765 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0056 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0238 0.2422
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0102 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Leishmania major DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0063 0.0661 0.0647
Schistosoma mansoni nAChR subunit 0.0063 0.0661 0.0647
Echinococcus multilocularis neuropeptide receptor 0.0138 0.1642 0.1638
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0277 0.0316
Brugia malayi hypothetical protein 0.0029 0.0212 0.0242
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0223 0.0205
Onchocerca volvulus 0.0031 0.0238 0.0218
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0223 0.2234
Echinococcus multilocularis potassium channel subfamily K 0.0031 0.0238 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0216 0.2137
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0063 0.0661 0.0755
Plasmodium vivax SET domain protein, putative 0.0098 0.111 1
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0052 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0216 0.0161
Loa Loa (eye worm) uncoordinated protein 58 0.0031 0.0238 0.022
Echinococcus multilocularis microtubule associated protein 2 0.0489 0.6254 0.6299
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0031 0.0238 0.2422
Onchocerca volvulus 0.003 0.0223 0.0203
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0184 0.2238 0.2241
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0102 0.0116
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0021 0.0024
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0063 0.0661 0.0647
Brugia malayi hypothetical protein 0.0029 0.0212 0.0242
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0184 0.2238 0.2241
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Giardia lamblia Fructose-bisphosphate aldolase 0.0207 0.255 1
Onchocerca volvulus 0.0063 0.0661 0.0642
Echinococcus multilocularis small conductance calcium activated potassium 0.0768 0.9917 1
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0503 0.5755
Onchocerca volvulus 0.0031 0.0238 0.0218
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0036 0.0301 0.3206
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0184 0.2238 0.2241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0277 0.0316
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0031 0.0238 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0102 0.0046
Schistosoma mansoni alpha-glucosidase 0.0115 0.1332 0.1325
Onchocerca volvulus 0.0031 0.0238 0.0218
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0661 0.0755
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0031 0.0238 0.022
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0102 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0205
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0223 0.077
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0102 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0098 0.111 0.1101
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0223 0.0168
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0668 0.0654
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0031 0.0238 0.2422
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Loa Loa (eye worm) glutaminase 2 0.0194 0.2374 0.2378
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1369 0.5731
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0027 0.0185 0.1253
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0062 0.0222
Loa Loa (eye worm) beta-lactamase 0.003 0.0223 0.0205
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0056 0.0036
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0301 0.0283
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0062 0.0205
Onchocerca volvulus 0.0063 0.0661 0.0642
Echinococcus granulosus twik family of potassium channels 0.0031 0.0238 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0062 0.0205
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0098 0.111 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0082
Brugia malayi hypothetical protein 0.0029 0.0212 0.0242
Loa Loa (eye worm) TWK-28 protein 0.0031 0.0238 0.022
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0223 0.0168
Leishmania major cytochrome p450-like protein 0.0039 0.0335 0.3631
Plasmodium falciparum thioredoxin reductase 0.0018 0.0062 0.0222
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0668 0.0654
Trichomonas vaginalis sucrase-isomaltase, putative 0.003 0.0216 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Schistosoma mansoni voltage-gated cation channel 0.0036 0.0301 0.0283
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0102 0.0082
Onchocerca volvulus 0.0063 0.0661 0.0642
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.111 0.1101
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0029 0.0212 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0841 0.0789
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0036 0.0301 0.3206
Brugia malayi neuropeptide F receptor 0.0015 0.0021 0.0024
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0062 0.0153
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0031 0.0238 0.0272
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0661 0.0755
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0082
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0102 0.0082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0192 0.2354 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0661 0.0755
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0661 0.0755
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0105 0.0085
Giardia lamblia Kinase, PLK 0.0077 0.0841 0.3148
Echinococcus granulosus glycine receptor subunit beta 0.0063 0.0661 0.0647
Schistosoma mansoni calcium-activated potassium channel 0.0031 0.0238 0.022
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0077 0.0841 0.0829
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0027 0.0185 0.1305
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0029 0.0212 0.0194
Echinococcus granulosus expressed protein 0.0406 0.5159 0.5193
Mycobacterium leprae conserved hypothetical protein 0.003 0.0223 0.1188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Echinococcus multilocularis potassium channel subfamily K 8 0.0031 0.0238 0.022
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0031 0.0238 0.0272
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0661 0.0647
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0063 0.0661 0.0647
Brugia malayi PXA domain containing protein 0.0021 0.0102 0.0116
Echinococcus granulosus potassium channel subfamily K 8 0.0031 0.0238 0.022
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0056 0.0129
Plasmodium vivax potassium channel, putative 0.0031 0.0238 0.1761
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0052 0.0079
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0029 0.0212 0.0194
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0205
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Brugia malayi Pre-SET motif family protein 0.0098 0.111 0.1266
Plasmodium falciparum histone acetyltransferase GCN5 0.0025 0.0155 0.2279
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0052 0.0079
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0335 0.3631
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0063 0.0661 0.0647
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0335 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0102 0.0046
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0101 0.1158 0.4817
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.0661 0.0647
Echinococcus multilocularis expressed protein 0.0406 0.5159 0.5193
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0238 0.0183
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0223 0.077
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0223 0.077
Schistosoma mansoni nAChR subunit 0.0063 0.0661 0.0647
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0668 0.0654
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0216 0.064
Echinococcus multilocularis G protein coupled receptor 139 0.0138 0.1642 0.1638
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0335 0.3631
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0052 0.0032
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0021 0.0024
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0105 0.012
Echinococcus multilocularis twik family of potassium channels 0.0031 0.0238 0.022
Mycobacterium tuberculosis Conserved protein 0.003 0.0223 0.077
Plasmodium falciparum thioredoxin reductase 0.0051 0.0503 1
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0216 0.0161
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0216 0.0161
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Giardia lamblia Histone acetyltransferase GCN5 0.0025 0.0155 0.0397
Schistosoma mansoni nAChR subunit 0.0063 0.0661 0.0647
Onchocerca volvulus 0.0031 0.0238 0.0218
Loa Loa (eye worm) LGC-31 protein 0.0063 0.0661 0.0647
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0216 0.0161
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0021 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0335 0.0317
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0063 0.0661 0.0755
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Echinococcus multilocularis neutral alpha glucosidase AB 0.003 0.0216 0.0197
Onchocerca volvulus 0.003 0.0223 0.0203
Leishmania major hypothetical protein, conserved 0.0031 0.0238 0.2422
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.033 0.0275
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0102 0.0116
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0216 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0223 0.2234
Echinococcus multilocularis twik family of potassium channels 0.0031 0.0238 0.022
Echinococcus granulosus voltage dependent calcium channel 0.0036 0.0301 0.0283
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0031 0.0238 0.0272
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0102 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Onchocerca volvulus 0.0029 0.0212 0.0192
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0335 0.3631
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0102 0.0082
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0223 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0184 0.2238 0.2241
Echinococcus granulosus dna polymerase eta 0.0017 0.0056 0.0036
Schistosoma mansoni hypothetical protein 0.0031 0.0238 0.022
Toxoplasma gondii ion channel protein 0.0031 0.0238 0.181
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0216 0.2137
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.1369 0.885
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Plasmodium falciparum glutathione reductase 0.0051 0.0503 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Loa Loa (eye worm) hypothetical protein 0.0032 0.0244 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0841 0.0789
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0102 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0098 0.111 0.1101
Trypanosoma cruzi polo-like protein kinase, putative 0.0077 0.0841 1
Leishmania major trypanothione reductase 0.0051 0.0503 0.5755
Brugia malayi hypothetical protein 0.0132 0.1567 0.1787
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0056 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0062 0.5
Brugia malayi G-protein coupled receptor 0.0015 0.0021 0.0024
Echinococcus granulosus neutral alpha glucosidase AB 0.003 0.0216 0.0197
Loa Loa (eye worm) GABA receptor subunit 0.0034 0.0277 0.0259
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0184 0.2238 0.2241
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0207 0.255 1
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0841 0.0789
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0031 0.0238 0.0272
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0062 0.007
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0105 0.0085
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0259
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0223 0.077
Brugia malayi PXA domain containing protein 0.0021 0.0102 0.0116
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0661 0.0647
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0052 0.0032
Onchocerca volvulus 0.0253 0.3147 0.3132
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0098 0.111 0.1101
Brugia malayi Cation transporter family protein 0.0063 0.0661 0.0755
Trypanosoma brucei polo-like protein kinase 0.0077 0.0841 1
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0052 0.0032
Loa Loa (eye worm) cytochrome P450 0.0017 0.0046 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Onchocerca volvulus 0.0031 0.0238 0.0218
Trichomonas vaginalis esterase, putative 0.003 0.0223 0.0168
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0052 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0205
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0062 0.0095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0098 0.111 0.1101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0062 0.0205
Brugia malayi jmjC domain containing protein 0.0017 0.0052 0.0059
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0031 0.0238 0.0272
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Onchocerca volvulus 0.0031 0.0238 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Plasmodium falciparum glutathione reductase 0.0018 0.0062 0.0222
Echinococcus granulosus potassium channel subfamily K 8 0.0031 0.0238 0.022
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0102 0.0082
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0062 0.0024
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0031 0.0238 0.2422
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0031 0.0238 0.0272
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0063 0.0661 0.0755
Brugia malayi Cytochrome P450 family protein 0.0039 0.0335 0.0382
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0661 0.0755
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0102 0.0082
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0031 0.0238 0.2422
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0102 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0841 0.0789
Echinococcus granulosus voltage dependent calcium channel 0.0036 0.0301 0.0283
Brugia malayi hypothetical protein 0.0031 0.0238 0.0272
Schistosoma mansoni nAChR subunit 0.0063 0.0661 0.0647
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0102 0.0082
Leishmania major calcium/potassium channel (CAKC), putative 0.0031 0.0238 0.2422
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.003 0.0216 0.0197
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0052 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0223 0.2234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0032
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0063 0.0661 0.0647
Brugia malayi G protein-coupled receptor 0.0015 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0207 0.255 0.2508
Leishmania major ion transport protein-like protein 0.0031 0.0238 0.2422
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0052 0.0059
Brugia malayi hypothetical protein 0.0021 0.0102 0.0116
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0105 0.0085
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Loa Loa (eye worm) ACC-1 protein 0.0063 0.0661 0.0647
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0036 0.0301 0.0283
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0062 0.0006
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0031 0.0238 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0238 0.2422
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0029 0.0212 0.0242
Entamoeba histolytica hypothetical protein 0.0021 0.0102 0.0184
Brugia malayi acetyltransferase, GNAT family protein 0.0092 0.1041 0.1187
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0063 0.0661 0.0755
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0102 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0205
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0063 0.0661 0.0647
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0668 0.0654
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0102 0.0116
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0036 0.0301 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0056 0.0129
Echinococcus multilocularis geminin 0.0433 0.5508 0.5545
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0102 0.0116
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0223 0.0763
Echinococcus granulosus nAChR subunit 0.0034 0.0277 0.0259
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0062 0.0205
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0052 0.0032
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0102 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0105 0.0085
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0052 0.0032
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0031 0.0238 0.0272
Plasmodium vivax glutathione reductase, putative 0.0051 0.0503 0.4267
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0031 0.0238 0.2422
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0212 0.0242
Mycobacterium tuberculosis Conserved protein 0.003 0.0223 0.077
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0031 0.0238 0.0272
Trichomonas vaginalis bromodomain-containing protein, putative 0.0027 0.0185 0.0129
Mycobacterium tuberculosis Conserved protein 0.003 0.0223 0.077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0032
Echinococcus granulosus microtubule associated protein 2 0.0489 0.6254 0.6299
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0082
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0031 0.0238 0.0834
Brugia malayi jmjC domain containing protein 0.0064 0.0668 0.0762
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0082
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0063 0.0661 0.0647
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0223 0.077
Echinococcus multilocularis nAChR subunit 0.0063 0.0661 0.0647
Schistosoma mansoni neuropeptide receptor 0.0138 0.1642 0.1638
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0052 0.0032
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0031 0.0238 0.022
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0062 0.0006
Loa Loa (eye worm) calcium channel 0.0036 0.0301 0.0283
Toxoplasma gondii transporter, cation channel family protein 0.0036 0.0301 0.2396
Echinococcus granulosus dna polymerase kappa 0.0017 0.0056 0.0036
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0052 0.0032
Mycobacterium leprae Probable lipase LipE 0.003 0.0223 0.1188
Schistosoma mansoni twik family of potassium channels-related 0.0031 0.0238 0.022
Echinococcus multilocularis calcium activated potassium channel variant 0.0031 0.0238 0.022
Mycobacterium ulcerans glutaminase 0.0194 0.2374 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.003 0.0216 0.1597
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0029 0.0212 0.0194
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0301 0.0283
Loa Loa (eye worm) ACC-1 protein 0.0063 0.0661 0.0647
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0184 0.2238 0.2241
Toxoplasma gondii ABC1 family protein 0.003 0.0223 0.1669
Loa Loa (eye worm) hypothetical protein 0.0184 0.2238 0.2241
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0668 0.0654
Brugia malayi beta-lactamase family protein 0.003 0.0223 0.0255
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0105 0.0085
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0052 0.0032
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0034 0.0277 0.0259
Brugia malayi Cytochrome P450 family protein 0.0039 0.0335 0.0382
Brugia malayi follicle stimulating hormone receptor 0.0265 0.3306 0.3772
Brugia malayi hypothetical protein 0.0015 0.0021 0.0024
Brugia malayi GnHR receptor homolog 0.0015 0.0021 0.0024
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0036 0.0301 0.0283
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.0647
Loa Loa (eye worm) hypothetical protein 0.0029 0.0212 0.0194
Brugia malayi G-protein coupled receptor 0.0015 0.0021 0.0024
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0062 0.0205
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0056 0.0044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.1541 0.6476

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 26 nM BindingDB_Patents: Radioligand Binding Assay I. For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 receptors, were washed with HEPES (10 mM, pH 7.5), scraped off the culture plates with the same buffer, and centrifuged at 4 C for 5 min at 2500 x g. The cell pellet was either stored at -80 C or used directly. Before the experiments, cell membranes were re-suspended in binding assay buffer (10 mM HEPES, 0.5% (w/v) bovine serum albumin, pH 7.5) by homogenisation with a Polytron homogeniser at 50 Hz for 20 s. In competition experiments, cell homogenates (150µ¿) were incubated in assay buffer (10 mM HEPES, pH 7.5, 0.5 % (w/v) bovine serum albumin, 5 mM MgCI2, 1 mMCaCI2, and tween 0.05%) for 1 h at room temperature with about 100 pM of the radioligand ([125l]orexin A, 2100 Ci/mmole, 50 µ¿), and with various concentrations of compounds of the invention (50 µ¿) in triplicates. ChEMBL. No reference
Kd (binding) = 50 nM BindingDB_Patents: Radioligand Binding Assay I . For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 receptors, were washed with HEPES (10 mM, pH 7.5), scraped off the culture plates with the same buffer, and centrifuged at 4 C for 5 min at 2500 x g. The cell pellet was either stored at -80 C or used directly. Before the experiments, cell membranes were re-suspended in binding assay buffer (10 mM HEPES, 0.5% (w/v) bovine serum albumin, pH 7.5) by homogenisation with a Polytron homogeniser at 50 Hz for 20 s. In competition experiments, cell homogenates (150ul) were incubated in assay buffer (10 mM HEPES, pH 7.5, 0.5 % (w/v) bovine serum albumin, 5 mM MgCI2, 1 mMCaCI2, and tween 0.05%) for 1 h at room temperature with about 100 pM of the radioligand ([125l]orexin A, 2100 Ci/mmole, 50 ul), and with various concentrations of compounds of the invention (50 ul) in triplicates. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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