TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 180.244 | Formula: C11H16O2
H donors: 0 H acceptors: 1 LogP: 2.34 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(=O)O[C@@H]1C[C@H]2[C@@H]1CC=C2
InChi: 1S/C11H16O2/c1-2-4-11(12)13-10-7-8-5-3-6-9(8)10/h3,5,8-10H,2,4,6-7H2,1H3/t8-,9-,10+/m0/s1
InChiKey: WRRCQTJDYJDXBF-LPEHRKFASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G-protein coupled receptor	0.0797	0.3266	0.3266
Onchocerca volvulus	Adenylate cyclase type 3 homolog	0.0091	0.0282	0.0863
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0797	0.3266	0.3266
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.0099	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0051	0.0051
Onchocerca volvulus		0.0036	0.0049	0.015
Schistosoma mansoni	purine nucleoside phosphorylase	0.0337	0.1321	0.129
Brugia malayi	jmjC domain containing protein	0.006	0.0152	0.0152
Onchocerca volvulus		0.0036	0.0049	0.015
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.4177
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0168	0.0133
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0797	0.3266	0.3266
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0127	0.0401
Echinococcus multilocularis	G protein coupled receptor 139	0.0797	0.3266	0.3266
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0032	0.0036	0.0256
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0049	0.0049
Brugia malayi	6-phosphofructokinase	0.0118	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0679	0.0679
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0797	0.3266	0.3242
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0797	0.3266	0.3266
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0797	0.3266	0.3266
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0054	0.0127	0.0127
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0054	0.0127	0.0127
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0049	0.0109
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0116	0.039	0.244
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0049	0.0109
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Entamoeba histolytica	hypothetical protein	0.0114	0.0379	0.2678
Schistosoma mansoni	serine/threonine protein kinase	0.0107	0.0351	0.0316
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Loa Loa (eye worm)	integrin alpha pat-2	0.0837	0.3433	0.3433
Echinococcus granulosus	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0039	0.0039
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0127	0.0127
Echinococcus granulosus	tm gpcr rhodopsin	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.006	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0426	0.1699	0.1699
Brugia malayi	Integrin alpha pat-2 precursor	0.0543	0.2192	0.2192
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0034	0.0107
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0152	0.0152
Brugia malayi	Cytochrome P450 family protein	0.0061	0.0158	0.0158
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0797	0.3266	0.3266
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0107	0.0351	0.2193
Brugia malayi	cytoplasmic intermediate filament protein	0.0032	0.0034	0.0034
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Echinococcus granulosus	integrin alpha ps	0.0243	0.0927	0.0927
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0315	0.1229	0.7711
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0116	0.039	0.244
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Brugia malayi	AKH receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	biogenic amine receptor	0.0797	0.3266	0.3242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0401	0.1593	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0118	0.0398	0.283
Brugia malayi	Dopamine receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	integrin alpha	0.0543	0.2192	0.2164
Echinococcus granulosus	g-protein coupled receptor	0.0797	0.3266	0.3266
Brugia malayi	putative neuropeptide receptor NPR1	0.0797	0.3266	0.3266
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0127	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0223	0.0223
Echinococcus multilocularis	g-protein coupled receptor	0.0797	0.3266	0.3266
Echinococcus granulosus	neuropeptide receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0168	0.0168
Leishmania major	nucleoside phosphorylase-like protein	0.0337	0.1321	0.8292
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0337	0.1321	0.8292
Trypanosoma brucei	protein kinase, putative	0.0107	0.0351	0.2193
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0407	0.0407
Chlamydia trachomatis	AMP nucleosidase	0.0337	0.1321	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0034	0.0107
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0077	0.0223	0.0704
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0049	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0127	0.0127
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0797	0.3266	0.3242
Mycobacterium leprae	probable uridine phosphorylase	0.2392	1	1
Echinococcus granulosus	adenylate cyclase 9	0.0091	0.0282	0.0282
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0039	0.0039
Schistosoma mansoni	uridine phosphorylase	0.2392	1	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0036	0.0212
Brugia malayi	sulfakinin receptor protein	0.0797	0.3266	0.3266
Brugia malayi	6-phosphofructokinase	0.0118	0.0398	0.0398
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0054	0.0127	0.0127
Schistosoma mansoni	integrin alpha-ps	0.0127	0.0434	0.04
Echinococcus granulosus	biogenic amine 5HT receptor	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0116	0.039	0.039
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0036	0.0036
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0054	0.0127	0.0127
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0171	0.0619	0.0619
Brugia malayi	Melatonin receptor type 1A	0.0797	0.3266	0.3266
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0337	0.1321	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0797	0.3266	0.3266
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	0.0337	0.1321	1
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0049	0.0014
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0168	0.0133
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.0528	0.3308
Schistosoma mansoni	intermediate filament proteins	0.006	0.0152	0.0116
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.0398	0.283
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0797	0.3266	0.3266
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0107	0.0351	0.2193
Brugia malayi	Adenylyl cyclase protein	0.0091	0.0282	0.0282
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0032	0.0036	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0797	0.3266	0.3266
Brugia malayi	G protein-coupled receptor	0.0797	0.3266	0.3266
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0337	0.1321	1
Entamoeba histolytica	hypothetical protein	0.0114	0.0379	0.2678
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0036	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0107	0.0351	0.2193
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0376	0.0376
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Echinococcus multilocularis	neuropeptide Y receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0039	0.0039
Treponema pallidum	uridine phosphorylase (udp)	0.0337	0.1321	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0188	0.0693	0.0693
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0054	0.0127	0.0127
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0337	0.1321	0.8292
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0202	0.0202
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0398	0.1259
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0054	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus multilocularis	integrin alpha ps	0.0243	0.0927	0.0927
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.0099	0.0624
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0034	0.0107
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Brugia malayi	hypothetical protein	0.0113	0.0376	0.0376
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0127	0.0092
Echinococcus granulosus	adenylate cyclase type IX	0.0127	0.0437	0.0437
Schistosoma mansoni	growth hormone secretagogue receptor	0.0797	0.3266	0.3242
Schistosoma mansoni	uridine phosphorylase	0.2392	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0797	0.3266	0.3266
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0002	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0342	0.0342
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0054	0.0127	0.0948
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0054	0.0127	0.0786
Onchocerca volvulus		0.0041	0.0071	0.0218
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0049	0.0296
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0036	0.0212
Echinococcus granulosus	mitogen activated protein kinase	0.0107	0.0351	0.0351
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0797	0.3266	0.3266
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.0135	0.0135
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.1058	0.4366	0.4366
Schistosoma mansoni	transcription factor LCR-F1	0.0114	0.0379	0.0344
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0051	0.0309
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0097	0.031	0.0276
Onchocerca volvulus		0.0797	0.3266	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.012	0.012
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0797	0.3266	0.3266
Schistosoma mansoni	hypothetical protein	0.0363	0.143	0.14
Onchocerca volvulus		0.0797	0.3266	1
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	lamin dm0	0.006	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	g protein coupled receptor	0.0797	0.3266	0.3266
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0337	0.1321	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Brugia malayi	Inositol-1	0.0036	0.0051	0.0051
Schistosoma mansoni	opsin-like receptor	0.0797	0.3266	0.3242
Brugia malayi	intermediate filament protein	0.006	0.0152	0.0152
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0127	0.0127
Mycobacterium ulcerans	putative regulatory protein	0.0041	0.0071	0.0173
Echinococcus granulosus	mitogen activated protein kinase 3	0.0107	0.0351	0.0351
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0202	0.0202
Schistosoma mansoni	amine GPCR	0.0797	0.3266	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0152	0.0152
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0083	0.0381
Schistosoma mansoni	biogenic amine receptor	0.0797	0.3266	0.3242
Echinococcus multilocularis	neuropeptide receptor	0.0797	0.3266	0.3266
Giardia lamblia	Hypothetical protein	0.0054	0.0127	0.0961
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0036	0.0212
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0797	0.3266	0.3242
Loa Loa (eye worm)	inositol-1	0.0036	0.0051	0.0051
Mycobacterium ulcerans	bifunctional Mta/Sah nucleosidase Mtn	0.0337	0.1321	1
Loa Loa (eye worm)	PDE1B protein	0.1159	0.4792	0.4792
Onchocerca volvulus		0.0773	0.3163	0.9687
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0039	0.0039
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0797	0.3266	0.3242
Echinococcus granulosus	neuropeptides capa receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0797	0.3266	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0345	0.1356	0.1356
Echinococcus granulosus	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0337	0.1321	0.8292
Echinococcus multilocularis	orexin receptor type 2	0.0797	0.3266	0.3266
Plasmodium falciparum	purine nucleoside phosphorylase	0.0337	0.1321	1
Toxoplasma gondii	hypothetical protein	0.0051	0.0113	0.0712
Brugia malayi	Dopamine receptor protein 2	0.0797	0.3266	0.3266
Schistosoma mansoni	neuropeptide F-like receptor	0.0797	0.3266	0.3242
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.0099	0.0099
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0948
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0797	0.3266	0.3266
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0797	0.3266	0.3242
Onchocerca volvulus		0.0797	0.3266	1
Echinococcus multilocularis	adenylate cyclase type IX	0.0127	0.0437	0.0437
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0797	0.3266	0.3266
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0049	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus multilocularis	geminin	0.0363	0.143	0.143
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0118	0.0398	0.2823
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0029	0.0021	0.0021
Schistosoma mansoni	lipoxygenase	0.0056	0.0135	0.01
Schistosoma mansoni	neuropeptide f receptor 76f	0.0797	0.3266	0.3242
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0036	0.0036
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.1159	0.4792	0.4773
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Schistosoma mansoni	neuropeptide receptor	0.0797	0.3266	0.3242
Toxoplasma gondii	6-phosphofructokinase	0.0032	0.0034	0.0212
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0077	0.0223	0.0188
Echinococcus multilocularis	dro:myosuppressin receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	hypothetical protein	0.0797	0.3266	0.3242
Onchocerca volvulus		0.0091	0.0282	0.0863
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0401	0.1593	1
Onchocerca volvulus		0.0797	0.3266	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0116	0.039	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1633	0.1633
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0051	0.0309
Schistosoma mansoni	amine GPCR	0.0797	0.3266	0.3242
Echinococcus granulosus	allatostatin A receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Leishmania major	mitochondrial DNA polymerase beta	0.0315	0.1229	0.7711
Trichomonas vaginalis	conserved hypothetical protein	0.0337	0.1321	0.4177
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0797	0.3266	0.3266
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0036	0.0036
Loa Loa (eye worm)	TYRA-2 protein	0.0797	0.3266	0.3266
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0337	0.1321	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0398	0.1259
Echinococcus granulosus	7tm_1 domain containing protein	0.0797	0.3266	0.3266
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0107	0.0351	0.2193
Onchocerca volvulus		0.0797	0.3266	1
Echinococcus granulosus	g protein coupled receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0049	0.0049
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0797	0.3266	0.3266
Mycobacterium tuberculosis	Hypothetical protein	0.0337	0.1321	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0797	0.3266	0.3266
Echinococcus granulosus	hypothetical protein	0.0797	0.3266	0.3266
Leishmania major	hypothetical protein, conserved	0.0036	0.0049	0.0296
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0049	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0127	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.0398	0.0364
Schistosoma mansoni	hypothetical protein	0.0033	0.0039	0.0004
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0029	0.0021	0.0021
Schistosoma mansoni	amine GPCR	0.0797	0.3266	0.3242
Leishmania major	hypothetical protein, conserved	0.0054	0.0127	0.0786
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0094	0.0294	0.0931
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	microtubule-associated protein tau	0.0769	0.3147	0.3122
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0116	0.039	0.244
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0797	0.3266	0.3266
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.1159	0.4792	0.4792
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0049	0.0049
Brugia malayi	G-protein coupled receptor	0.0797	0.3266	0.3266
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0051	0.0161
Loa Loa (eye worm)	neuropeptide F receptor	0.0797	0.3266	0.3266
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0401
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.0342	0.0342
Brugia malayi	Intermediate filament tail domain containing protein	0.006	0.0152	0.0152
Onchocerca volvulus		0.006	0.0152	0.0465
Echinococcus granulosus	serotonin receptor	0.0797	0.3266	0.3266
Toxoplasma gondii	phosphorylase family protein	0.0337	0.1321	0.8294
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0051	0.0051
Entamoeba histolytica	hypothetical protein	0.0114	0.0379	0.2678
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0086	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0985	0.0985
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0094	0.0294	0.1839
Echinococcus granulosus	uridine phosphorylase 1	0.2392	1	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0051	0.0161
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0797	0.3266	0.3242
Onchocerca volvulus		0.0797	0.3266	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0188	0.0693	0.0693
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0054	0.0127	0.0948
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0337	0.1321	0.129
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0036	0.0036
Brugia malayi	Pre-SET motif family protein	0.0097	0.031	0.031
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.0158	0.0158
Brugia malayi	Pre-SET motif family protein	0.0679	0.2767	0.2767
Echinococcus granulosus	sex peptide receptor	0.0797	0.3266	0.3266
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0049	0.0296
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0797	0.3266	0.3266
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0077	0.0223	0.0704
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Brugia malayi	Serotonin receptor	0.0797	0.3266	0.3266
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0315	0.1229	0.7711
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0051	0.0015
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0337	0.1321	0.1291
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Schistosoma mansoni	hypothetical protein	0.0797	0.3266	0.3242
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0049	0.0109
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0797	0.3266	0.3266
Schistosoma mansoni	hypothetical protein	0.0797	0.3266	0.3242
Echinococcus granulosus	tm gpcr rhodopsin	0.0797	0.3266	0.3266
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0166	0.0599	0.4387
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.4177
Echinococcus granulosus	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Plasmodium vivax	SET domain protein, putative	0.0097	0.031	0.1938
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	lamin	0.006	0.0152	0.0152
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Giardia lamblia	hypothetical protein	0.0054	0.0127	0.0961
Toxoplasma gondii	phosphorylase family protein	0.0337	0.1321	0.8294
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.1094	0.8233
Echinococcus granulosus	intermediate filament protein	0.006	0.0152	0.0152
Brugia malayi	Dopamine receptor protein 1	0.0797	0.3266	0.3266
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.0168	0.1057
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0051	0.0015
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0168	0.0168
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0112	0.0372	0.0372
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0051	0.0015
Brugia malayi	MAP kinase sur-1	0.0107	0.0351	0.0351
Leishmania major	hypothetical protein, conserved	0.0054	0.0127	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0329	0.0329
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0097	0.031	0.1947
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0401
Brugia malayi	Kelch motif family protein	0.0113	0.0376	0.0376
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0054	0.0127	0.0401
Echinococcus granulosus	histone lysine methyltransferase setb	0.0097	0.031	0.031
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0107	0.0351	0.0351
Brugia malayi	neuropeptide F receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	mitogen activated protein kinase	0.0107	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0049	0.0049
Echinococcus granulosus	integrin alpha 3	0.0416	0.1657	0.1657
Toxoplasma gondii	phosphofructokinase PFKII	0.0032	0.0034	0.0212
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0034	0.0107
Onchocerca volvulus		0.0797	0.3266	1
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0077	0.0223	0.0223
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0077	0.0223	0.0223
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0049	0.0049
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0315	0.1229	0.7711
Echinococcus granulosus	microtubule associated protein 2	0.0769	0.3147	0.3147
Echinococcus granulosus	integrin beta 2	0.0551	0.2224	0.2224
Loa Loa (eye worm)	hypothetical protein	0.03	0.1164	0.1164
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0054	0.0127	0.0401
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0049	0.0109
Leishmania major	methylthioadenosine phosphorylase, putative	0.0337	0.1321	0.8292
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Giardia lamblia	UPL-1	0.0337	0.1321	1
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0049	0.0296
Echinococcus granulosus	neuropeptides capa receptor	0.0797	0.3266	0.3266
Echinococcus granulosus	tm gpcr rhodopsin	0.0797	0.3266	0.3266
Brugia malayi	larval opioid receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0398	0.1259
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0113	0.0376	0.0376
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0919	0.3777	0.3777
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0083	0.0613
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0054	0.0127	0.0961
Onchocerca volvulus		0.0097	0.031	0.095
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0034	0.02
Schistosoma mansoni	neuropeptide F-like receptor	0.0797	0.3266	0.3242
Echinococcus granulosus	g protein coupled receptor	0.0797	0.3266	0.3266
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0337	0.1321	1
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0337	0.1321	0.1321
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.4177
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0168	0.0133
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0401	0.1593	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0127	0.0401
Loa Loa (eye worm)	integrin beta-2	0.0743	0.3038	0.3038
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0147	0.0147
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0337	0.1321	0.8292
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	uridine phosphorylase	0.2392	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	intermediate filament protein	0.006	0.0152	0.0152
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0162	0.0581	0.0547
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Brugia malayi	hypothetical protein	0.0185	0.0679	0.0679
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0054	0.0127	0.0127
Plasmodium falciparum	phosphodiesterase delta, putative	0.0054	0.0127	0.0948
Toxoplasma gondii	ABC1 family protein	0.0036	0.0049	0.0308
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0049	0.0049
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Onchocerca volvulus		0.0797	0.3266	1
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Brugia malayi	follicle stimulating hormone receptor	0.1058	0.4366	0.4366
Brugia malayi	RE15519p	0.0797	0.3266	0.3266
Mycobacterium ulcerans	hypothetical protein	0.0166	0.0599	0.4326
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0351	0.1109
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0401	0.1593	0.1593
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0127	0.0786
Brugia malayi	neuropeptide F receptor	0.0797	0.3266	0.3266
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0337	0.1321	0.1321
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.0398	0.249
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0351	0.1109
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0049	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus multilocularis	g protein coupled receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0786
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0036	0.0036
Echinococcus multilocularis	6 phosphofructokinase	0.0118	0.0398	0.0398
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.0985	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	single-minded	0.0055	0.0132	0.0096
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0337	0.1321	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0797	0.3266	0.3266
Schistosoma mansoni	lamin	0.006	0.0152	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Echinococcus multilocularis	neuropeptide s receptor	0.0797	0.3266	0.3266
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.0168	0.0168
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0051	0.5
Schistosoma mansoni	hypothetical protein	0.0033	0.0039	0.0004
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.0398	0.0398
Brugia malayi	jmjC domain containing protein	0.006	0.0152	0.0152
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus multilocularis	neuropeptides capa receptor	0.0797	0.3266	0.3266
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0116	0.039	0.244
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0049	0.0155
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Trichomonas vaginalis	set domain proteins, putative	0.0773	0.3163	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0034	0.0241
Echinococcus granulosus	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Brugia malayi	bHLH-PAS transcription factor	0.0041	0.0071	0.0071
Onchocerca volvulus		0.0036	0.0049	0.015
Loa Loa (eye worm)	6-phosphofructokinase	0.0118	0.0398	0.0398
Brugia malayi	GnHR receptor homolog	0.0797	0.3266	0.3266
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0032	0.0036	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.0398	0.283
Onchocerca volvulus	Adenylate cyclase type 2 homolog	0.0091	0.0282	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0054	0.0127	0.0786
Echinococcus granulosus	somatostatin receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0168	0.0168
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0112	0.0372	0.0372
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0036	0.0036
Echinococcus multilocularis	adenylate cyclase 9	0.0091	0.0282	0.0282
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0797	0.3266	0.3242
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Mycobacterium ulcerans	6-phosphofructokinase	0.0118	0.0398	0.2744
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus multilocularis	fmrfamide receptor	0.0797	0.3266	0.3266
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0036	0.0212
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0168	0.0168
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0032	0.0034	0.0107
Echinococcus multilocularis	g protein coupled receptor	0.0797	0.3266	0.3266
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.0099	0.0624
Onchocerca volvulus		0.0797	0.3266	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0152	0.0117
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0283	0.1094	0.8233
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0337	0.1321	0.1321
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0797	0.3266	0.3266
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0051	0.0309
Brugia malayi	beta-lactamase	0.0036	0.0049	0.0049
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0054	0.0127	0.0092
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0168	0.0133
Entamoeba histolytica	hypothetical protein	0.0337	0.1321	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.031	0.031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0188	0.0693	0.0693
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0036	0.0224
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0351	0.1109
Brugia malayi	MH2 domain containing protein	0.012	0.0407	0.0407
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0039	0.0039
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.1159	0.4792	0.4792
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.0168	0.0168
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0337	0.1321	0.8292
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0797	0.3266	0.3242
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0337	0.1321	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0049	0.0155
Echinococcus granulosus	nuclear factor of activated T cells 5	0.008	0.0237	0.0237
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.8292
Plasmodium vivax	phosphodiesterase gamma, putative	0.0054	0.0127	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	geminin	0.0363	0.143	0.143
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0114	0.0379	0.0379
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0138	0.0483	0.3408
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0097	0.031	0.031
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0118	0.0398	0.249
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0016	0.0016
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0679	0.2767	0.2767
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0049	0.0049
Echinococcus multilocularis	serotonin receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	musashi	0.006	0.0152	0.0152
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0054	0.0127	0.0401
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0049	0.0109
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0051	0.032
Onchocerca volvulus		0.006	0.0152	0.0465
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0127	0.0401
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Mycobacterium tuberculosis	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase	0.0337	0.1321	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0283	0.1094	0.8233
Echinococcus multilocularis	lamin	0.006	0.0152	0.0152
Brugia malayi	MTAP	0.0337	0.1321	0.1321
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0054	0.0127	0.0786
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0401
Brugia malayi	hypothetical protein	0.0024	0.0002	0.0002
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0162	0.0581	0.0581
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0152	0.0117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0797	0.3266	0.3242
Echinococcus multilocularis	neuropeptide Y receptor	0.0797	0.3266	0.3266
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0032	0.0036	0.0212
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0054	0.0127	0.0786
Trichomonas vaginalis	esterase, putative	0.0036	0.0049	0.0155
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0127	0.0786
Schistosoma mansoni	hypothetical protein	0.0797	0.3266	0.3242
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0188	0.0693	0.0693
Schistosoma mansoni	hypothetical protein	0.0052	0.012	0.0085
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0149	0.0528	0.3308
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0162	0.0512
Echinococcus granulosus	6 phosphofructokinase	0.0118	0.0398	0.0398
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0411	0.1633	0.1633
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0097	0.031	0.0276
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.0168	0.1047
Echinococcus multilocularis	somatostatin receptor	0.0797	0.3266	0.3266
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0051	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0049	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0797	0.3266	0.3266
Brugia malayi	acetyltransferase, GNAT family protein	0.0162	0.0581	0.0581
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0127	0.0092
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0054	0.0127	0.0401
Echinococcus multilocularis	fmrfamide receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0797	0.3266	0.3266
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0083	0.0626
Echinococcus multilocularis	sex peptide receptor	0.0797	0.3266	0.3266
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0077	0.0223	0.0704
Trichomonas vaginalis	conserved hypothetical protein	0.0337	0.1321	0.4177
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0077	0.0223	0.0223
Loa Loa (eye worm)	adenylyl cyclase 3	0.0214	0.0804	0.0804
Echinococcus granulosus	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0337	0.1321	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0797	0.3266	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0094	0.0294	0.0931
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0337	0.1321	1
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Loa Loa (eye worm)	acetyltransferase	0.0162	0.0581	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0077	0.0223	0.0223
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0337	0.1321	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0114	0.0379	0.0344
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0086	0.0528
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0036	0.0224
Schistosoma mansoni	hypothetical protein	0.0033	0.0039	0.0004
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0337	0.1321	0.8292
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.008	0.0237	0.0237
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0034	0.0241
Trypanosoma brucei	hypothetical protein, conserved	0.0054	0.0127	0.0786
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0401	0.1593	1
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Brugia malayi	hypoxia-induced factor 1	0.0171	0.0619	0.0619
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.4177
Echinococcus multilocularis	transfer RNA-Lys	0.0041	0.0071	0.0071
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0138	0.0483	0.3479
Echinococcus multilocularis	serotonin receptor	0.0797	0.3266	0.3266
Onchocerca volvulus		0.0797	0.3266	1
Leishmania major	ATP-dependent phosphofructokinase	0.0118	0.0398	0.249
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Entamoeba histolytica	phosphofructokinase, putative	0.0118	0.0398	0.283
Schistosoma mansoni	purine nucleoside phosphorylase	0.0337	0.1321	0.129
Brugia malayi	TAR-binding protein	0.0064	0.0168	0.0168
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0138	0.0483	0.0449
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0116	0.039	0.1233
Echinococcus multilocularis	integrin alpha ps	0.0243	0.0927	0.0927
Schistosoma mansoni	neuropeptide receptor	0.0797	0.3266	0.3242
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0054	0.0127	0.0127
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0054	0.0127	0.0127
Echinococcus multilocularis	lamin dm0	0.006	0.0152	0.0152
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0049	0.0109
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Echinococcus multilocularis	microtubule associated protein 2	0.0769	0.3147	0.3147
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	dro:myosuppressin receptor	0.0797	0.3266	0.3266
Brugia malayi	hypothetical protein	0.0257	0.0985	0.0985
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0049	0.0155
Schistosoma mansoni	neuropeptide receptor	0.0797	0.3266	0.3242
Onchocerca volvulus		0.0087	0.0266	0.0813
Echinococcus granulosus	biogenic amine 5HT receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	neuropeptide receptor	0.0797	0.3266	0.3242
Echinococcus granulosus	neuropeptide receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	melatonin receptor type 1A	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Schistosoma mansoni	integrin alpha-ps	0.0243	0.0927	0.0894
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Schistosoma mansoni	hypothetical protein	0.0363	0.143	0.14
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Schistosoma mansoni	opsin-like receptor	0.0797	0.3266	0.3242
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0401	0.1593	1
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	GPCR family 2	0.0033	0.0039	0.0039
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0401	0.1593	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0036	0.0036
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0094	0.0295	0.0295
Trichomonas vaginalis	phosphofructokinase, putative	0.0118	0.0398	0.1259
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0337	0.1321	1
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Brugia malayi	phosphofructokinase	0.0118	0.0398	0.0398
Echinococcus multilocularis	neuropeptide receptor A26	0.0797	0.3266	0.3266
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Onchocerca volvulus		0.0797	0.3266	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0797	0.3266	0.3242
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0107	0.0351	0.0351
Brugia malayi	beta-lactamase family protein	0.0036	0.0049	0.0049
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0049	0.0109
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0127	0.0092
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0283	0.1094	0.3458
Brugia malayi	PAS domain containing protein	0.0055	0.0132	0.0132
Onchocerca volvulus		0.0797	0.3266	1
Onchocerca volvulus		0.0797	0.3266	1
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0168	0.0168
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0337	0.1321	0.129
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0034	0.0107
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0054	0.0127	0.0948
Echinococcus granulosus	neuropeptide FF receptor 2	0.0797	0.3266	0.3266
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0116	0.039	0.1233
Schistosoma mansoni	6-phosphofructokinase	0.0118	0.0398	0.0364
Schistosoma mansoni	hypothetical protein	0.0033	0.0039	0.0004
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.4177
Trypanosoma brucei	uridine phosphorylase	0.0337	0.1321	0.8292
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.0693	0.066
Brugia malayi	Steroid receptor seven-up type 2	0.0112	0.0372	0.0372
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.0342	0.0342
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0051	0.0134
Onchocerca volvulus		0.0797	0.3266	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0049	0.0049
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0086	0.0528
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.0693	0.066
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0168	0.0133
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Brugia malayi	putative neuropeptide receptor	0.0797	0.3266	0.3266
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0116	0.039	0.039
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0021	0.0021
Echinococcus granulosus	neuropeptide receptor A26	0.0797	0.3266	0.3266
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.039	0.1233
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Treponema pallidum	purine nucleoside phosphorylase (deoD)	0.0337	0.1321	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.0127	0.0785
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.0168	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0797	0.3266	0.3242
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.0099	0.0613
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0039	0.0039
Brugia malayi	Serotonin receptor	0.0797	0.3266	0.3266
Treponema pallidum	pfs protein (pfs)	0.0337	0.1321	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0797	0.3266	0.3266
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0797	0.3266	1
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0407	0.0407
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0168	0.0938
Entamoeba histolytica	hypothetical protein	0.0114	0.0379	0.2678
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0152	0.0152
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	lamin	0.006	0.0152	0.0116
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0032	0.0034	0.0212
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0051	0.0161
Schistosoma mansoni	integrin beta subunit	0.0438	0.1747	0.1718
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0002	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Echinococcus granulosus	G protein coupled receptor 139	0.0797	0.3266	0.3266
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0039	0.0039
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0786
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0337	0.1321	0.4177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.0135	0.0135
Giardia lamblia	Kinase, CMGC MAPK	0.0107	0.0351	0.2656
Loa Loa (eye worm)	phosphofructokinase	0.0118	0.0398	0.0398
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0127	0.0786
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0034	0.02
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	opsin-like receptor	0.0797	0.3266	0.3242
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0401	0.1593	0.1593
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0116	0.039	0.244
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus multilocularis	allatostatin A receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	g protein coupled receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	hypothetical protein	0.0072	0.0202	0.0167
Schistosoma mansoni	histamine h1 receptor	0.0797	0.3266	0.3242
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.0985	0.0985
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0797	0.3266	0.3242
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0107	0.0351	0.2193
Schistosoma mansoni	survival motor neuron protein	0.0052	0.012	0.0085
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.006	0.0152	0.0152
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.0858	0.6402
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0168	0.0133
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0097	0.031	0.0276
Echinococcus granulosus	single minded 2	0.0041	0.0071	0.0071
Schistosoma mansoni	biogenic amine receptor	0.0797	0.3266	0.3242
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0114	0.0379	0.0379
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0797	0.3266	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Brugia malayi	ORL1-like opioid receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	aryl hydrocarbon receptor	0.0055	0.0132	0.0096
Schistosoma mansoni	amine GPCR	0.0797	0.3266	0.3242
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0168	0.0938
Onchocerca volvulus		0.0797	0.3266	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0168	0.0133
Brugia malayi	hypothetical protein	0.0114	0.0379	0.0379
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0086	0.0528
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0797	0.3266	0.3266
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Onchocerca volvulus		0.0052	0.012	0.0369
Brugia malayi	beta-lactamase family protein	0.0036	0.0049	0.0049
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.1159	0.4792	0.4792
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.4177
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0157	0.0562	0.0562
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0797	0.3266	0.3266
Onchocerca volvulus		0.0797	0.3266	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0797	0.3266	0.3242
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0127	0.0786
Schistosoma mansoni	hypothetical protein	0.0117	0.0392	0.0357
Giardia lamblia	Fructose-bisphosphate aldolase	0.0283	0.1094	0.8278
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0049	0.0109
Echinococcus granulosus	integrin alpha ps	0.0117	0.0392	0.0392
Echinococcus granulosus	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0188	0.0693	0.0693
Echinococcus multilocularis	integrin alpha ps	0.0117	0.0392	0.0392
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0118	0.0398	0.0364
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0049	0.0049
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0097	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0392	0.0392
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0097	0.031	0.0276
Schistosoma mansoni	myosin xvIII	0.0797	0.3266	0.3242
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.0528	0.3308
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0107	0.0351	0.2193
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0188	0.0693	0.0693
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0032	0.0034	0.0034
Brugia malayi	RNA binding protein	0.0064	0.0168	0.0168
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0797	0.3266	0.3242
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0337	0.1321	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0337	0.1321	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0049	0.0155
Brugia malayi	G protein-coupled receptor F59B2.13	0.0797	0.3266	0.3266
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0337	0.1321	0.8294
Loa Loa (eye worm)	neuropeptide F receptor	0.0797	0.3266	0.3266
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Echinococcus granulosus	neuropeptide Y receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	integrin beta 2	0.0551	0.2224	0.2224
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0039	0.0039
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.0099	0.0314
Brugia malayi	Integrin beta pat-3 precursor	0.0743	0.3038	0.3038
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0152	0.0117
Echinococcus granulosus	orexin receptor type 2	0.0797	0.3266	0.3266
Echinococcus multilocularis	uridine phosphorylase 1	0.2392	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0797	0.3266	0.3266
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0337	0.1321	0.129
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0049	0.0296
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0127	0.0092
Brugia malayi	hypothetical protein	0.0797	0.3266	0.3266
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0797	0.3266	0.3266
Echinococcus granulosus	neuropeptide s receptor	0.0797	0.3266	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0127	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0162	0.0512
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0797	0.3266	0.3242
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0127	0.0401
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0049	0.0049
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0337	0.1321	0.4045
Echinococcus granulosus	fmrfamide receptor	0.0797	0.3266	0.3266
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0152	0.0152
Brugia malayi	hypothetical protein	0.0132	0.0458	0.0458
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0107	0.0351	0.2193
Schistosoma mansoni	adenoreceptor	0.0797	0.3266	0.3242
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0948
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0054	0.0127	0.0786
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0127	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0266	0.0266
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0116	0.039	0.1233
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0039	0.0039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0797	0.3266	0.3266
Echinococcus granulosus	neuropeptide Y receptor	0.0797	0.3266	0.3266
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0049	0.0013
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0401	0.1593	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0116	0.039	0.1233
Toxoplasma gondii	hypothetical protein	0.0062	0.0162	0.1017
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0127	0.0786
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0034	0.0107
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0127	0.0092
Echinococcus multilocularis	neuropeptide receptor	0.0797	0.3266	0.3266
Onchocerca volvulus		0.0797	0.3266	1
Trichomonas vaginalis	CMGC family protein kinase	0.0107	0.0351	0.1109
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0032	0.0034	0.0255
Schistosoma mansoni	amine GPCR	0.0797	0.3266	0.3242
Loa Loa (eye worm)	nuclear hormone receptor	0.0101	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0797	0.3266	0.3266
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0049	0.0013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.0693	0.066
Echinococcus granulosus	Solute carrier family 22 5	0.1184	0.4899	0.4899
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0337	0.1321	0.1321
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0054	0.0127	0.0127
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.0342	0.0342
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0337	0.1321	0.4177
Echinococcus multilocularis	integrin alpha 3	0.0416	0.1657	0.1657
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0797	0.3266	0.3266
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0054	0.0127	0.0797
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0168	0.0938
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0162	0.0512
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0107	0.0351	0.2203

Activities

Activity type	Activity value	Assay description	Source	Reference
k cat (binding)	= 3560 s-1	Tested for hydrolysis with 0.5 ug/mL of PPL (porcine pancreatic lipase), 1.5 ug/mL of colipase and 4 mM of sodium taurodeoxycholatet (NaTDC) at the compound dose of 0.2 g	ChEMBL.	No reference
k cat (binding)	= 3560 s-1	Tested for hydrolysis with 0.5 ug/mL of PPL (porcine pancreatic lipase), 1.5 ug/mL of colipase and 4 mM of sodium taurodeoxycholatet (NaTDC) at the compound dose of 0.2 g	ChEMBL.	No reference
k cat (binding)	= 3870 s-1	Tested for hydrolysis with 0.2 ug/mL of PPL (porcine pancreatic lipase) at the compound dose of 0.2 g	ChEMBL.	No reference
k cat (binding)	= 3870 s-1	Tested for hydrolysis with 0.2 ug/mL of PPL (porcine pancreatic lipase) at the compound dose of 0.2 g	ChEMBL.	No reference
Ki (binding)	= 220 s-1	Tested for hydrolysis with 0.5 ug/mL of PPL (porcine pancreatic lipase), 1.5 ug/mL of colipase and 4 mM of sodium taurodeoxycholatet (NaTDC) at the compound dose of 0.2 g	ChEMBL.	No reference
Ki (binding)	= 220 s-1	Tested for hydrolysis with 0.5 ug/mL of PPL (porcine pancreatic lipase), 1.5 ug/mL of colipase and 4 mM of sodium taurodeoxycholatet (NaTDC) at the compound dose of 0.2 g	ChEMBL.	No reference
Ki (binding)	= 2100 s-1	Tested for hydrolysis with 0.2 ug/mL of PPL (porcine pancreatic lipase) at the compound dose of 0.2 g	ChEMBL.	No reference
Ki (binding)	= 2100 s-1	Tested for hydrolysis with 0.2 ug/mL of PPL (porcine pancreatic lipase) at the compound dose of 0.2 g	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL119630

Bibliographic References

No literature references available for this target.

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Detailed information for compound 206291