Detailed information for compound 2071535

Basic information

Technical information
  • TDR Targets ID: 2071535
  • Name: N-(2-morpholin-4-ylethyl)-4-oxo-3H-phthalazin e-1-carboxamide
  • MW: 302.328 | Formula: C15H18N4O3
  • H donors: 2 H acceptors: 2 LogP: 0.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1n[nH]c(=O)c2c1cccc2)NCCN1CCOCC1
  • InChi: 1S/C15H18N4O3/c20-14-12-4-2-1-3-11(12)13(17-18-14)15(21)16-5-6-19-7-9-22-10-8-19/h1-4H,5-10H2,(H,16,21)(H,18,20)
  • InChiKey: JNDBXVVQECKECS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-morpholinoethyl)-4-oxo-3H-phthalazine-1-carboxamide
  • 4-keto-N-(2-morpholinoethyl)-3H-phthalazine-1-carboxamide
  • T0519-4068

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin 0.0031 0.0188 0.0183
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0023 0.0018
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0032 0.02 0.2363
Entamoeba histolytica hypothetical protein 0.0079 0.0817 1
Mycobacterium leprae Probable two component sensor kinase MprB 0.0032 0.02 0.8614
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0032 0.02 0.8614
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0226 1
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0032 0.02 0.2363
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0495 0.6234 0.857
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0575 0.7274 0.7273
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0032 0.02 0.2363
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0201 0.2402 0.3113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0104 0.1142 0.3965
Brugia malayi Phospholipase A2 family protein 0.0072 0.0715 0.0983
Trichomonas vaginalis glucosylceramidase, putative 0.0325 0.4016 0.6324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0258 0.0355
Loa Loa (eye worm) hypothetical protein 0.0032 0.02 0.0275
Entamoeba histolytica hypothetical protein 0.0079 0.0817 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0032 0.02 0.0572
Echinococcus multilocularis Polycystic kidney disease protein 0.0036 0.0258 0.0253
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0023 0.0031
Schistosoma mansoni DNA topoisomerase II 0.0032 0.02 0.0178
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0023 0.0018
Brugia malayi nuclear receptor NHR-88 0.0018 0.0023 0.0031
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0575 0.7274 1
Trichomonas vaginalis glucosylceramidase, putative 0.0495 0.6234 1
Echinococcus multilocularis musashi 0.0031 0.0188 0.0183
Plasmodium vivax heat shock protein 86, putative 0.0032 0.02 0.7321
Loa Loa (eye worm) hypothetical protein 0.0031 0.0188 0.0258
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0023 0.0018
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0157 0.1835 0.2523
Entamoeba histolytica hypothetical protein 0.0079 0.0817 1
Mycobacterium ulcerans DNA gyrase subunit B 0.0032 0.02 0.2363
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0023 0.0031
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0023 0.0031
Entamoeba histolytica hypothetical protein 0.0079 0.0817 1
Onchocerca volvulus 0.0055 0.0501 0.1141
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0226 1
Mycobacterium ulcerans putative regultory protein 0.0032 0.02 0.2363
Loa Loa (eye worm) hypothetical protein 0.034 0.421 0.5788
Echinococcus granulosus heat shock protein 90 0.0032 0.02 0.0195
Schistosoma mansoni hypothetical protein 0.0312 0.3854 0.384
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0032 0.02 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0032 0.02 0.8614
Brugia malayi CXXC zinc finger family protein 0.0055 0.0501 0.0688
Trichomonas vaginalis glucosylceramidase, putative 0.0325 0.4016 0.6324
Loa Loa (eye worm) hypothetical protein 0.0053 0.0473 0.0651
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0023 0.0018
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0032 0.02 0.2363
Echinococcus multilocularis heat shock protein 0.0032 0.02 0.0195
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0226 0.2743
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0226 0.2743
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0226 0.0036
Schistosoma mansoni cytochrome P450 0.0034 0.0226 0.0203
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.02 0.022
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0032 0.02 0.022
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0032 0.02 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0072 0.0715 0.0983
Echinococcus granulosus L aminoadipate semialdehyde 0.007 0.07 0.0695
Chlamydia trachomatis DNA gyrase subunit B 0.0032 0.02 1
Brugia malayi Probable DNA topoisomerase II 0.0032 0.02 0.0275
Schistosoma mansoni cpg binding protein 0.0058 0.0542 0.052
Echinococcus multilocularis cpg binding protein 0.0058 0.0542 0.0537
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0226 0.2743
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0495 0.6234 0.857
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0226 0.2743
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0188 0.0258
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0023 0.0018
Schistosoma mansoni heat shock protein 0.0032 0.02 0.0178
Toxoplasma gondii heat shock protein HSP90 0.0032 0.02 0.0572
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0188 0.0258
Loa Loa (eye worm) hypothetical protein 0.0032 0.02 0.0275
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.02 0.0572
Onchocerca volvulus Glucosylceramidase homolog 0.0325 0.4016 0.9536
Echinococcus granulosus lipoxygenase domain containing protein 0.0036 0.0258 0.0253
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0226 0.2743
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0032 0.02 0.7321
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0575 0.7274 0.7273
Mycobacterium tuberculosis Conserved protein 0.0032 0.02 0.8614
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0023 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0023 0.0031
Onchocerca volvulus 0.007 0.07 0.1616
Leishmania major DNA topoisomerase ii 0.0032 0.02 0.022
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0226 1
Onchocerca volvulus 0.0036 0.0258 0.0562
Loa Loa (eye worm) TOPoisomerase family member 0.0032 0.02 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0023 0.0031
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0032 0.02 0.0195
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0032 0.02 0.2363
Brugia malayi nuclear hormone receptor 0.0018 0.0023 0.0031
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0226 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0226 1
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0023 0.0018
Giardia lamblia Pms1-like protein 0.0032 0.02 0.5
Echinococcus granulosus intermediate filament protein 0.0031 0.0188 0.0183
Entamoeba histolytica DNA topoisomerase II, putative 0.0032 0.02 0.2048
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0032 0.02 0.0195
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.0714 0.0726
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Echinococcus granulosus heat shock protein 0.0032 0.02 0.0195
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0023 0.0018
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0226 0.2743
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0248
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0575 0.7274 1
Schistosoma mansoni hypothetical protein 0.0034 0.0226 0.0203
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0226 0.2743
Mycobacterium leprae Probable two-component sensor kinase 0.0032 0.02 0.8614
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0817 0.0812
Leishmania major cytochrome p450-like protein 0.0071 0.0714 0.093
Leishmania major developmentally regulated phosphoprotein-like protein 0.0575 0.7274 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0226 0.2743
Loa Loa (eye worm) doublecortin family protein 0.0036 0.0258 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0023 0.0031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0023 0.0031
Plasmodium vivax DNA topoisomerase II, putative 0.0032 0.02 0.7321
Schistosoma mansoni cpg binding protein 0.0058 0.0542 0.052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0055 0.0501 0.0688
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0023 0.0018
Schistosoma mansoni endoplasmin 0.0032 0.02 0.0178
Echinococcus granulosus cpg binding protein 0.0058 0.0542 0.0537
Echinococcus multilocularis lipoxygenase domain containing protein 0.0036 0.0258 0.0253
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0023 0.0031
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0714 0.0981
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0032 0.02 0.8614
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0032 0.02 0.0423
Schistosoma mansoni loxhd1 0.0036 0.0258 0.0236
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0233 0.2819 1
Trichomonas vaginalis glucosylceramidase, putative 0.0325 0.4016 0.6324
Schistosoma mansoni polycystin 1-related 0.0036 0.0258 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0226 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.02 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0023 0.0018
Schistosoma mansoni heat shock protein 0.0032 0.02 0.0178
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0226 1
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0817 0.0796
Echinococcus multilocularis RUN 0.0036 0.0258 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.02 0.0572
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Loa Loa (eye worm) hypothetical protein 0.0067 0.0652 0.0896
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0117 0.1305 0.1285
Brugia malayi Cytochrome P450 family protein 0.0071 0.0714 0.0981
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0226 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.0042 0.0333 0.0457
Mycobacterium ulcerans two component sensor kinase MprB 0.0032 0.02 0.2363
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.007 0.07 0.0678
Brugia malayi intermediate filament protein 0.0031 0.0188 0.0258
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0023 0.0018
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0226 0.2743
Schistosoma mansoni lipoxygenase 0.0152 0.1769 0.175
Echinococcus multilocularis L aminoadipate semialdehyde 0.007 0.07 0.0695
Echinococcus granulosus lamin 0.0031 0.0188 0.0183
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0032 0.02 0.8614
Onchocerca volvulus Phospholipase A2 homolog 0.0072 0.0715 0.1654
Echinococcus multilocularis 0.0034 0.0226 0.022
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0032 0.02 0.8614
Trichomonas vaginalis glucosylceramidase, putative 0.0325 0.4016 0.6324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0258 0.0355
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0218
Echinococcus granulosus lamin dm0 0.0031 0.0188 0.0183
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0201 0.2402 0.3264
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0023 0.0031
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0226 0.2743
Brugia malayi ecdysteroid receptor 0.0018 0.0023 0.0031
Schistosoma mansoni hypothetical protein 0.0029 0.0159 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0495 0.6234 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0032 0.02 0.2363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0023 0.0018
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Plasmodium falciparum LCCL domain-containing protein 0.0036 0.0258 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0333 0.0457
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.0714 0.0726
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0032 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0023 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0023 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4244 0.6702
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0023 0.0031
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0226 0.2743
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0226 0.2743
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Echinococcus multilocularis tumor protein p63 0.0362 0.4499 0.4496
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0373
Schistosoma mansoni intermediate filament proteins 0.0031 0.0188 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0023 0.0031
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0226 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0032 0.02 0.7321
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0002 0.0003
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0032 0.02 0.0275
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.02 0.2048
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0071 0.0714 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0032 0.02 0.8614
Plasmodium vivax hypothetical protein, conserved 0.0032 0.02 0.7321
Onchocerca volvulus 0.0031 0.0188 0.0394
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Leishmania major mitochondrial DNA topoisomerase II 0.0032 0.02 0.022
Plasmodium vivax endoplasmin, putative 0.0032 0.02 0.7321
Echinococcus granulosus RUN 0.0036 0.0258 0.0253
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0201 0.2402 0.3264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Schistosoma mansoni lamin 0.0031 0.0188 0.0165
Onchocerca volvulus Phospholipase A2 homolog 0.034 0.421 1
Echinococcus multilocularis heat shock protein 90 0.0032 0.02 0.0195
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0817 0.0812
Brugia malayi hypothetical protein 0.0036 0.0258 0.0355
Brugia malayi cytochrome P450 0.0034 0.0226 0.031
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.02 0.2048
Schistosoma mansoni hypothetical protein 0.0784 1 1
Trypanosoma brucei DNA topoisomerase ii 0.0032 0.02 0.022
Trypanosoma brucei developmentally regulated phosphoprotein 0.0575 0.7274 1
Schistosoma mansoni hypothetical protein 0.0079 0.0817 0.0796
Mycobacterium ulcerans two component regulator - sensor kinase 0.0032 0.02 0.2363
Schistosoma mansoni endoplasmin 0.0032 0.02 0.0178
Brugia malayi kinase, mitochondrial precursor 0.0575 0.7274 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0226 0.0255
Loa Loa (eye worm) hypothetical protein 0.0124 0.14 0.1925
Brugia malayi steroid hormone receptor 0.0018 0.0023 0.0031
Plasmodium falciparum heat shock protein 90 0.0032 0.02 0.7321
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0159 0.0218
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0226 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0032 0.02 0.8614
Leishmania major cytochrome p450-like protein 0.0034 0.0226 0.0255
Echinococcus multilocularis geminin 0.0312 0.3854 0.3851
Schistosoma mansoni cpg binding protein 0.0055 0.0501 0.0479
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0226 1
Brugia malayi follicle stimulating hormone receptor 0.0248 0.3016 0.4145
Schistosoma mansoni lamin 0.0031 0.0188 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0023 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0226 1
Brugia malayi Cytochrome P450 family protein 0.0071 0.0714 0.0981
Trichomonas vaginalis glucosylceramidase, putative 0.0325 0.4016 0.6324
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0218 0.2624 0.262
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0032 0.02 0.2363
Trichomonas vaginalis glucosylceramidase, putative 0.0495 0.6234 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0023 0.0018
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0032 0.02 0.0423
Trypanosoma brucei cytochrome P450, putative 0.0071 0.0714 0.093
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0226 0.2743
Echinococcus granulosus lipoxygenase domain containing protein 0.0036 0.0258 0.0253
Schistosoma mansoni hypothetical protein 0.0312 0.3854 0.384
Brugia malayi Endoplasmin precursor 0.0032 0.02 0.0275
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0032 0.02 0.2363
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0226 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0023 0.0031
Brugia malayi Doublecortin family protein 0.0036 0.0258 0.0355
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0226 0.2743
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0226 0.2743
Brugia malayi hypothetical protein 0.0036 0.0258 0.0355
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0032 0.02 0.8614
Brugia malayi heat shock protein 90 0.0032 0.02 0.0275
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0057 0.0532 0.051
Plasmodium vivax multidomain scavenger receptor, putative 0.0036 0.0258 1
Echinococcus multilocularis dnaJ subfamily B 0.0784 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.0036 0.0258 0.0253
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.02 0.022
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0714 0.0981
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0032 0.02 0.8614
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Schistosoma mansoni hypothetical protein 0.0036 0.0258 0.0236
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0023 0.0031
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0218 0.2624 0.262
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0333 0.0457
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.02 0.0572
Trichomonas vaginalis glucosylceramidase, putative 0.0495 0.6234 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0023 0.0031
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0226 0.0036
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0226 0.2743
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.007 0.07 0.0962
Schistosoma mansoni pyruvate dehydrogenase 0.0575 0.7274 0.7268
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0023 0.0018
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0032 0.02 0.8614
Mycobacterium leprae putative cytochrome p450 0.0034 0.0226 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0023 0.0031
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Loa Loa (eye worm) heat shock protein 90 0.0032 0.02 0.0275
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0032 0.02 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0023 0.0031
Echinococcus multilocularis lamin dm0 0.0031 0.0188 0.0183
Loa Loa (eye worm) CYP4Cod1 0.0071 0.0714 0.0981
Schistosoma mansoni pyruvate dehydrogenase 0.0543 0.6858 0.6851
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0188 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0342 0.4244 0.6702
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0023 0.0031
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0032 0.02 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0226 0.2743
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0032 0.02 0.8614
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0226 1
Chlamydia trachomatis DNA gyrase subunit B 0.0032 0.02 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0226 0.2743
Echinococcus multilocularis lipoxygenase domain containing protein 0.0036 0.0258 0.0253
Schistosoma mansoni lipoxygenase 0.0218 0.2624 0.2607
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0226 0.2743
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0226 1
Leishmania major hypothetical protein, conserved 0.0032 0.02 0.022
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Mycobacterium tuberculosis Probable two component sensor kinase 0.0032 0.02 0.8614
Trichomonas vaginalis glucosylceramidase, putative 0.0495 0.6234 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0226 1
Echinococcus granulosus tumor protein p63 0.0362 0.4499 0.4496
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0032 0.02 0.0275
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0032 0.02 0.8614
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0575 0.7274 0.7273
Loa Loa (eye worm) hypothetical protein 0.0033 0.0217 0.0298
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.007 0.07 0.0962
Onchocerca volvulus 0.0031 0.0188 0.0394
Brugia malayi Cytochrome P450 family protein 0.0096 0.1036 0.1425
Leishmania major cytochrome p450-like protein 0.0034 0.0226 0.0255
Plasmodium falciparum endoplasmin, putative 0.0032 0.02 0.7321
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0023 0.0031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0333 0.0457
Schistosoma mansoni pyruvate dehydrogenase 0.0543 0.6858 0.6851
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0226 1
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Plasmodium falciparum DNA gyrase subunit B 0.0032 0.02 0.7321
Trichomonas vaginalis glucosylceramidase, putative 0.0325 0.4016 0.6324
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.02 0.022
Leishmania major heat shock protein 83-1 0.0032 0.02 0.022
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0023 0.0018
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0226 1
Trichomonas vaginalis glucosylceramidase, putative 0.0325 0.4016 0.6324
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0226 0.022
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0032 0.02 0.8614
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0023 0.0031
Loa Loa (eye worm) endoplasmin 0.0032 0.02 0.0275
Onchocerca volvulus 0.0036 0.0258 0.0562
Schistosoma mansoni rab6-interacting 0.0036 0.0258 0.0236
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0032 0.02 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.02 0.5
Plasmodium falciparum DNA topoisomerase 2 0.0032 0.02 0.7321
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0201 0.2402 0.85
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0226 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0226 0.2743
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0032 0.02 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0032 0.02 0.8614
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0005 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0473 0.0452
Echinococcus granulosus geminin 0.0312 0.3854 0.3851
Brugia malayi hypothetical protein 0.0079 0.0817 0.1123
Onchocerca volvulus 0.0053 0.0473 0.1076
Schistosoma mansoni rab6-interacting 0.0036 0.0258 0.0236
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0226 1
Trichomonas vaginalis glucosylceramidase, putative 0.0495 0.6234 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.02 0.022
Brugia malayi Cytochrome P450 family protein 0.0034 0.0226 0.031
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0226 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0023 0.0031
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0032 0.02 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.0226 0.0664
Loa Loa (eye worm) cytochrome P450 family protein 0.0096 0.1036 0.1425
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0023 0.0031
Loa Loa (eye worm) cytochrome P450 0.0034 0.0226 0.031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.3016 0.4145

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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