Detailed information for compound 2072586

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 482.504 | Formula: C25H27FN4O5
  • H donors: 3 H acceptors: 4 LogP: 2.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(n1)c(NC(=O)[C@]1(O)CC[C@H](CC1)NCc1ccc3c(c1)OCCO3)c(cn2)F
  • InChi: 1S/C25H27FN4O5/c1-33-21-5-3-18-23(29-21)22(17(26)14-28-18)30-24(31)25(32)8-6-16(7-9-25)27-13-15-2-4-19-20(12-15)35-11-10-34-19/h2-5,12,14,16,27,32H,6-11,13H2,1H3,(H,28,30,31)/t16-,25+
  • InChiKey: MRQMAVKQTJLRGW-NDQYQSCMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0148 0.0286
Schistosoma mansoni tyrosine kinase 0.001 0.0053 0.0102
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0003 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0131 0.089 0.1714
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0064 0.0115
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0148 0.0286
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0004 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0003 0.0005 0.0009
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0148 0.0278
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Brugia malayi ecdysone receptor 0.0002 0.0002 0.0003
Trichomonas vaginalis ABC transporter, putative 0.0003 0.0005 0.0001
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0003 0.0005 0.0001
Plasmodium falciparum ABC transporter B family member 5, putative 0.0003 0.0005 0.0005
Leishmania major pentamidine resistance protein 1 0.0011 0.0064 0.0114
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0018 0.0035
Entamoeba histolytica hypothetical protein 0.0023 0.0148 0.0278
Onchocerca volvulus 0.0027 0.0173 0.1172
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0148 0.0286
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0004 0.0018 0.0025
Echinococcus multilocularis tyrosine protein kinase HCK 0.0008 0.004 0.0077
Echinococcus multilocularis tyrosine protein kinase Srms 0.0009 0.0047 0.009
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0011 0.0064 0.0114
Trichomonas vaginalis DNA helicase recq, putative 0.0003 0.0007 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Loa Loa (eye worm) multidrug resistance protein 3 0.0003 0.0005 0.0009
Trypanosoma cruzi lysophospholipase, putative 0.0004 0.0014 0.0018
Onchocerca volvulus 0.0004 0.0018 0.0111
Schistosoma mansoni multidrug resistance protein 0.0011 0.0064 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0018 0.0035
Trichomonas vaginalis ABC transporter, putative 0.0003 0.0005 0.0001
Trichomonas vaginalis abcb9, putative 0.0003 0.0005 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0027 0.0173 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0018 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Toxoplasma gondii ABC transporter, putative 0.0003 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor 0.0002 0.0002 0.0003
Schistosoma mansoni glutaminase 0.007 0.0468 0.0901
Mycobacterium leprae conserved hypothetical protein 0.0131 0.089 0.1849
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0002 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0005 0.0018 0.0035
Plasmodium vivax hexose transporter 0.0004 0.0018 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0148 0.0286
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Schistosoma mansoni acyl-protein thioesterase 12 (lysophospholipase III) 0.0004 0.0014 0.0027
Trypanosoma cruzi hexose transporter, putative 0.0004 0.0018 0.0025
Entamoeba histolytica ABC transporter, putative 0.0011 0.0064 0.0115
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0003 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0002 0.0002 0.0003
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0053 0.0102
Schistosoma mansoni sugar transporter 0.0004 0.0018 0.0034
Echinococcus granulosus solute carrier family 22 0.0004 0.0018 0.0027
Schistosoma mansoni sugar transporter 0.0004 0.0018 0.0034
Entamoeba histolytica P-glycoprotein-2 0.0003 0.0005 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0148 0.0286
Onchocerca volvulus 0.0131 0.089 0.6072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0047 0.009
Onchocerca volvulus Huntingtin homolog 0.0031 0.0203 0.1374
Brugia malayi conserved hypotetical protein 0.0002 0.0002 0.0003
Brugia malayi nuclear receptor NHR-88 0.0005 0.0018 0.0035
Loa Loa (eye worm) multidrug resistance-associated protein 0.0009 0.0047 0.009
Trichomonas vaginalis abcb9, putative 0.0003 0.0005 0.0001
Entamoeba histolytica hypothetical protein 0.0011 0.0064 0.0115
Brugia malayi nuclear hormone receptor family member nhr-6 0.0002 0.0002 0.0003
Echinococcus granulosus tyrosine protein kinase Blk 0.0009 0.0047 0.0072
Brugia malayi Sugar transporter family protein 0.0004 0.0018 0.0034
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0011 0.0064 0.0114
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0148 0.0286
Onchocerca volvulus 0.0004 0.0018 0.0111
Schistosoma mansoni sugar transporter 0.0004 0.0018 0.0034
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0756 0.5193 1
Schistosoma mansoni smdr2 0.0003 0.0005 0.0009
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0011 0.0064 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trypanosoma cruzi lysophospholipase, putative 0.0004 0.0014 0.0018
Giardia lamblia Multidrug resistance-associated protein 1 0.0011 0.0064 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0027 0.0173 0.0333
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0004 0.0017 0.0032
Schistosoma mansoni nuclear receptor 0.0002 0.0002 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0002 0.0002 0.0003
Echinococcus multilocularis acyl protein thioesterase 1 0.0004 0.0014 0.0027
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0011 0.0064 0.0123
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0064 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0002 0.0003 0.0006
Entamoeba histolytica P-glycoprotein 5, putative 0.0003 0.0005 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0756 0.5193 1
Brugia malayi hypothetical protein 0.0004 0.0018 0.0034
Onchocerca volvulus 0.0004 0.0018 0.0111
Mycobacterium tuberculosis Conserved protein 0.0131 0.089 0.0886
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0005 0.0018 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Trypanosoma cruzi multidrug resistance protein E, putative 0.0011 0.0064 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Toxoplasma gondii ABC transporter family protein 0.0003 0.0005 0.0005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0003 0.0005 0.0009
Onchocerca volvulus Huntingtin homolog 0.0031 0.0203 0.1374
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0053 0.0081
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0018 0.0035
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0003 0.0005 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0756 0.5193 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0002 0.0003 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0002 0.0002 0.0003
Trichomonas vaginalis abcb9, putative 0.0003 0.0005 0.0001
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0018 0.0035
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0148 0.0286
Schistosoma mansoni multidrug resistance protein 0.0003 0.0005 0.0009
Schistosoma mansoni multidrug resistance protein 0.0011 0.0064 0.0123
Loa Loa (eye worm) hypothetical protein 0.0131 0.089 0.1714
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0131 0.089 0.1707
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus multilocularis ATP binding cassette sub family B 0.0002 0.0004 0.0008
Entamoeba histolytica P-glycoprotein-1 0.0003 0.0005 0.0001
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0148 0.0286
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0333
Echinococcus granulosus ATP binding cassette sub family B 0.0002 0.0004 0.0006
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0003 0.0005 0.0001
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0148 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis DNA helicase recq1, putative 0.0005 0.0024 0.0039
Trypanosoma brucei THT1 - hexose transporter, putative 0.0004 0.0018 0.0025
Echinococcus granulosus Sugar transporter ERD6 protein 0.0004 0.0018 0.0027
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0002 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0023 0.0148 0.0278
Schistosoma mansoni nuclear receptor nhr-48 0.0002 0.0002 0.0003
Echinococcus multilocularis multidrug resistance protein 1 0.0003 0.0005 0.0009
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0002 0.0002 0.0005
Mycobacterium leprae Probable lipase LipE 0.0131 0.089 0.1849
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0148 0.0227
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0002 0.0004 0.0008
Onchocerca volvulus 0.0003 0.0005 0.0022
Toxoplasma gondii phospholipase/carboxylesterase 0.0004 0.0014 0.0023
Echinococcus multilocularis ATP binding cassette sub family B 0.0003 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Echinococcus granulosus synaptic vesicle 2 protein 0.0004 0.0018 0.0027
Schistosoma mansoni multidrug resistance protein 0.0003 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.039
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Loa Loa (eye worm) glutaminase 2 0.007 0.0468 0.0901
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus granulosus multidrug resistance protein 1 0.0003 0.0005 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0005 0.0018 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0053 0.0102
Trichomonas vaginalis DNA helicase recq, putative 0.0005 0.0024 0.0039
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0053 0.0102
Echinococcus granulosus beta LACTamase domain containing family member 0.0131 0.089 0.1364
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0189 0.1285 0.2475
Echinococcus multilocularis FTZ F1 alpha 0.0005 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Trichomonas vaginalis esterase, putative 0.0131 0.089 0.1707
Onchocerca volvulus 0.0215 0.1465 1
Trypanosoma brucei p-glycoprotein 0.0011 0.0064 0.0114
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0838 0.5757 0.5755
Brugia malayi ecdysteroid receptor 0.0005 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0003 0.0005 0.0001
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0003 0.0005 0.0007
Schistosoma mansoni glucose transport protein 0.0004 0.0018 0.0034
Schistosoma mansoni DNA helicase recq1 0.0002 0.0002 0.0005
Trypanosoma brucei lysophospholipase, putative 0.0004 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0005 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0756 0.5193 1
Mycobacterium ulcerans esterase/lipase LipP 0.0131 0.089 0.0886
Schistosoma mansoni DNA helicase recq5 0.0002 0.0002 0.0005
Brugia malayi multidrug resistance related protein 1 0.0011 0.0064 0.0123
Plasmodium vivax SET domain protein, putative 0.0027 0.0173 0.0325
Onchocerca volvulus 0.0004 0.0018 0.0111
Toxoplasma gondii facilitative glucose transporter GT1 0.0004 0.0018 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0005 0.0018 0.0028
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Brugia malayi Major Facilitator Superfamily protein 0.0004 0.0018 0.0034
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0004 0.0012 0.0018
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0003 0.0005 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0756 0.5193 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0002 0.0004 0.0006
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0148 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus granulosus acyl protein thioesterase 12 0.0004 0.0014 0.0022
Echinococcus multilocularis solute carrier family 22 0.0004 0.0018 0.0034
Echinococcus granulosus Nuclear hormone receptor HR96 0.0002 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0005 0.0018 0.0035
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0053 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Plasmodium falciparum ABC transporter B family member 3, putative 0.0003 0.0005 0.0005
Brugia malayi Sugar transporter family protein 0.0004 0.0018 0.0034
Schistosoma mansoni glucose transport protein 0.0004 0.0018 0.0034
Plasmodium falciparum multidrug resistance-associated protein 2 0.0003 0.0005 0.0005
Brugia malayi major facilitator superfamily protein 0.0004 0.0018 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0002 0.0002 0.0002
Brugia malayi hypothetical protein 0.0023 0.0148 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0005 0.0018 0.0035
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0002 0.0002 0.000000000013605
Loa Loa (eye worm) TK protein kinase 0.0008 0.004 0.0077
Entamoeba histolytica recQ family helicase, putative 0.0003 0.0007 0.0005
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0756 0.5193 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0166 0.0255
Echinococcus multilocularis multidrug resistance associated protein 7 0.0011 0.0064 0.0123
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0003 0.0005 0.0007
Trypanosoma cruzi hexose transporter, putative 0.0004 0.0018 0.0025
Brugia malayi hypothetical protein 0.0003 0.0005 0.0009
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0148 0.0286
Echinococcus granulosus ATP binding cassette sub family B 0.0003 0.0005 0.0007
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0011 0.0064 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0018 0.0035
Onchocerca volvulus 0.0004 0.0018 0.0111
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0148 0.0286
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0002 0.0004 0.0003
Giardia lamblia Multidrug resistance-associated protein 1 0.0011 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0005 0.0018 0.0035
Schistosoma mansoni smdr1 0.0003 0.0005 0.0009
Onchocerca volvulus Putative transporter 0.0004 0.0018 0.0111
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0131 0.089 0.1714
Echinococcus granulosus multidrug resistance protein 1 0.0003 0.0005 0.0007
Brugia malayi hypothetical protein 0.0002 0.0002 0.0003
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0003 0.0005 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0005 0.0018 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0002 0.0002 0.0003
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0003 0.0005 0.0009
Mycobacterium tuberculosis Conserved protein 0.0131 0.089 0.0886
Echinococcus granulosus tyrosine protein kinase HCK 0.0008 0.004 0.0061
Schistosoma mansoni sugar transporter 0.0004 0.0018 0.0034
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0148 0.0227
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0005 0.0018 0.0035
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0009 0.0047 0.0072
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0002 0.0003 0.0005
Echinococcus multilocularis expressed protein 0.0457 0.3133 0.6033
Brugia malayi hypothetical protein 0.0004 0.0018 0.0034
Onchocerca volvulus 0.0131 0.089 0.6072
Plasmodium vivax sugar transporter, putative 0.0004 0.0018 0.0025
Brugia malayi ABC transporter 0.0003 0.0005 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0148 0.0286
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0148 0.0286
Trypanosoma cruzi sugar transporter, putative 0.0004 0.0018 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0005 0.0018 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0131 0.089 0.1707
Brugia malayi Phospholipase/Carboxylesterase family protein 0.0004 0.0014 0.0027
Brugia malayi beta-lactamase family protein 0.0131 0.089 0.1714
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0148 0.0286
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0002 0.0002 0.0003
Toxoplasma gondii transporter, major facilitator family protein 0.0004 0.0018 0.003
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0003 0.0005 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0005 0.0018 0.0035
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0011 0.0064 0.0114
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0131 0.089 0.0886
Onchocerca volvulus 0.0004 0.0018 0.0111
Brugia malayi Nuclear hormone receptor E75 0.0002 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0148 0.0286
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0004 0.0012 0.0015
Schistosoma mansoni tyrosine kinase 0.0002 0.0002 0.0004
Brugia malayi ABC transporter 0.0002 0.0004 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0131 0.089 0.0886
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0131 0.089 0.1714
Brugia malayi Pre-SET motif family protein 0.0189 0.1285 0.2475
Loa Loa (eye worm) sugar transporter 0.0004 0.0018 0.0034
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0148 0.0286
Loa Loa (eye worm) ABC transporter 0.0003 0.0005 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0005 0.0018 0.0028
Echinococcus granulosus solute carrier family 22 0.0004 0.0018 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0148 0.0278
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0148 0.0286
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0053 0.0102
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0003 0.0005 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0131 0.089 0.1714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0173 0.0333
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0004 0.0018 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0002 0.0003 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0005 0.0018 0.0035
Echinococcus multilocularis bloom syndrome protein 0.0005 0.0024 0.0047
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0053 0.0081
Mycobacterium ulcerans lipase LipD 0.0131 0.089 0.0886
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0018 0.0035
Toxoplasma gondii sugar transporter ST3 0.0004 0.0018 0.003
Plasmodium falciparum multidrug resistance protein 1 0.0003 0.0005 0.0005
Echinococcus granulosus tyrosine kinase 0.0009 0.0047 0.0072
Loa Loa (eye worm) beta-lactamase 0.0131 0.089 0.1714
Trypanosoma brucei THT1 - hexose transporter, putative 0.0004 0.0018 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0005 0.0018 0.0035
Plasmodium falciparum hexose transporter 0.0004 0.0018 0.003
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0003 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0002 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Brugia malayi steroid hormone receptor 0.0005 0.0018 0.0035
Loa Loa (eye worm) sugar transporter 0.0004 0.0018 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0005 0.0018 0.0028
Echinococcus granulosus multidrug resistance associated protein 7 0.0011 0.0064 0.0098
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Trypanosoma cruzi glucose transporter, putative 0.0004 0.0018 0.0025
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0011 0.0064 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0005 0.0018 0.0035
Brugia malayi protein-tyrosine kinase 0.0009 0.0047 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0286
Loa Loa (eye worm) major facilitator superfamily transporter 0.0004 0.0018 0.0034
Brugia malayi Major Facilitator Superfamily protein 0.0004 0.0018 0.0034
Echinococcus granulosus solute carrier family 22 0.0004 0.0018 0.0027
Echinococcus multilocularis multidrug resistance associated protein 4 0.0009 0.0046 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Entamoeba histolytica P-glycoprotein-2, putative 0.0003 0.0005 0.0001
Mycobacterium ulcerans hypothetical protein 0.033 0.226 0.2256
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0148 0.0286
Brugia malayi hypothetical protein 0.0002 0.0003 0.0006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0148 0.0286
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0002 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0004 0.0018 0.0034
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0064 0.0115
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0005 0.0018 0.0035
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0148 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Plasmodium falciparum ABC transporter B family member 4, putative 0.0003 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0064 0.0123
Brugia malayi ABC transporter transmembrane region family protein 0.0003 0.0005 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus multilocularis ATP binding cassette sub family B 0.0003 0.0005 0.0009
Echinococcus multilocularis solute carrier family 22 0.0004 0.0018 0.0034
Echinococcus multilocularis multidrug resistance associated protein 1 0.0011 0.0064 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0005 0.0018 0.0035
Trypanosoma cruzi hypothetical protein 0.0009 0.0046 0.0079
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0005 0.002 0.0034
Plasmodium falciparum ABC transporter B family member 6, putative 0.0003 0.0005 0.0005
Loa Loa (eye worm) ABC transporter 0.0003 0.0005 0.0009
Trichomonas vaginalis ABC transporter, putative 0.0003 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Onchocerca volvulus 0.0004 0.0018 0.0111
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0002 0.0002 0.0003
Mycobacterium ulcerans integral membrane transport protein 0.0004 0.0018 0.0013
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0004 0.0018 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0005 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Echinococcus granulosus multidrug resistance protein 1 0.0003 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0002 0.0003 0.0006
Brugia malayi Pre-SET motif family protein 0.0027 0.0173 0.0333
Trypanosoma brucei multidrug resistance protein E 0.0011 0.0064 0.0114
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0027 0.0173 0.0329
Brugia malayi nuclear receptor RXR 0.0002 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Loa Loa (eye worm) major facilitator superfamily transporter 0.0004 0.0018 0.0034
Brugia malayi hypothetical protein 0.0002 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0148 0.0278
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0148 0.0286
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0004 0.0018 0.0027
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0003 0.0005 0.0005
Entamoeba histolytica P-glycoprotein-5 0.0003 0.0005 0.0001
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0148 0.0286
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0003 0.0005 0.0001
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0002 0.0002 0.0003
Echinococcus multilocularis microtubule associated protein 2 0.0396 0.2712 0.5223
Plasmodium falciparum ABC transporter B family member 7, putative 0.0003 0.0005 0.0005
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.1454 1 1
Brugia malayi nuclear receptor NHR-88 0.0002 0.0002 0.0003
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0004 0.0018 0.0034
Schistosoma mansoni multidrug resistance protein 0.0011 0.0064 0.0123
Brugia malayi nuclear hormone receptor family member odr-7 0.0002 0.0002 0.0003
Onchocerca volvulus 0.0004 0.0018 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0131 0.089 0.1706
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0004 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0131 0.089 0.1714
Onchocerca volvulus 0.0004 0.0018 0.0111
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0003 0.0005 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.0005 0.0018 0.0028
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0148 0.0227
Entamoeba histolytica protein kinase, putative 0.0008 0.004 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Mycobacterium ulcerans lipoprotein LpqF 0.0698 0.4793 0.4791
Schistosoma mansoni multidrug resistance protein 0.0003 0.0005 0.0009
Echinococcus multilocularis acyl protein thioesterase 12 0.0004 0.0014 0.0027
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0002 0.0002 0.0005
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0053 0.0081
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0148 0.0227
Schistosoma mansoni steroid hormone receptor ad4bp 0.0005 0.0018 0.0035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0002 0.0003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0148 0.0278
Echinococcus granulosus acyl protein thioesterase 1 0.0004 0.0014 0.0022
Plasmodium falciparum multidrug resistance-associated protein 1 0.0003 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0053 0.0081
Echinococcus multilocularis tyrosine protein kinase Blk 0.0009 0.0047 0.009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0002 0.0002 0.0004
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0064 0.0115
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0004 0.0018 0.0013
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0053 0.0081
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0756 0.5193 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0003 0.0005 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0002 0.0002 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0005 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Echinococcus granulosus microtubule associated protein 2 0.0396 0.2712 0.4156
Schistosoma mansoni multidrug resistance protein 0.0003 0.0005 0.0009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0003 0.0005 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Echinococcus granulosus multidrug resistance associated protein 4 0.0009 0.0046 0.007
Brugia malayi PXA domain containing protein 0.0023 0.0148 0.0286
Brugia malayi Sugar transporter family protein 0.0004 0.0018 0.0034
Onchocerca volvulus 0.0004 0.0018 0.0111
Giardia lamblia MRP-like ABC transporter 0.0011 0.0064 0.0118
Schistosoma mansoni acyl-protein thioesterase 12 (lysophospholipase III) 0.0004 0.0014 0.0027
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0148 0.0227
Trichomonas vaginalis penicillin-binding protein, putative 0.0131 0.089 0.1707
Mycobacterium ulcerans beta-lactamase 0.0131 0.089 0.0886
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0018 0.0035
Entamoeba histolytica hypothetical protein 0.0023 0.0148 0.0278
Loa Loa (eye worm) TK protein kinase 0.0009 0.0047 0.009
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0011 0.0064 0.0114
Schistosoma mansoni tyrosine kinase 0.0002 0.0002 0.0004
Toxoplasma gondii ABC1 family protein 0.0131 0.089 0.171
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0004 0.0018 0.0027
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0756 0.5193 1
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0756 0.5193 1
Mycobacterium ulcerans glutaminase 0.007 0.0468 0.0464
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0002 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0203 0.039
Brugia malayi ABC transporter family protein 0.0003 0.0005 0.0009
Mycobacterium tuberculosis Probable hydrolase 0.0131 0.089 0.0886
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0148 0.0286
Giardia lamblia Hypothetical protein 0.0002 0.0004 0.0003
Plasmodium falciparum multidrug resistance protein 2 0.0003 0.0005 0.0005
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0148 0.0286
Brugia malayi nuclear hormone receptor 0.0005 0.0018 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Schistosoma mansoni multidrug resistance protein 0.0011 0.0064 0.0123
Brugia malayi beta-lactamase family protein 0.0131 0.089 0.1714
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0011 0.0064 0.0118
Schistosoma mansoni RAR-like nuclear receptor 0.0005 0.0018 0.0035
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0053 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0148 0.0278
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0004 0.0018 0.0034
Echinococcus granulosus histone lysine methyltransferase setb 0.0027 0.0173 0.0265
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0131 0.089 0.1714
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0005 0.0018 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0018 0.0028
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0008 0.0045 0.0086
Echinococcus granulosus Solute carrier family 22 5 0.0949 0.6527 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.089 0.1714
Onchocerca volvulus 0.0004 0.0018 0.0111
Loa Loa (eye worm) ABC transporter 0.0003 0.0005 0.0009
Schistosoma mansoni glucose transport protein 0.0004 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Trichomonas vaginalis ABC transporter, putative 0.0003 0.0005 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0131 0.089 0.1707
Echinococcus multilocularis tyrosine protein kinase Abl 0.0002 0.0002 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0002 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.0756 0.5193 1
Brugia malayi SRC-1 0.001 0.0053 0.0102
Schistosoma mansoni tyrosine kinase 0.001 0.0053 0.0102
Trichomonas vaginalis glucose transporter, putative 0.0004 0.0018 0.0026
Giardia lamblia Multidrug resistance-associated protein 1 0.0011 0.0063 0.0117
Trypanosoma cruzi hexose transporter, putative 0.0004 0.0018 0.0025
Echinococcus multilocularis ecdysone induced protein 78C 0.0005 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0002 0.0004 0.0008
Echinococcus multilocularis solute carrier family 22 0.0004 0.0018 0.0034
Trypanosoma brucei glucose transporter 2A 0.0004 0.0018 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0005 0.0018 0.0035
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0148 0.0286
Echinococcus multilocularis 0.0756 0.5193 1
Loa Loa (eye worm) RecQ helicase 0.0005 0.0024 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0131 0.089 0.1707
Loa Loa (eye worm) nuclear receptor NHR-67 0.0002 0.0002 0.0003
Leishmania major glucose transporter, lmgt1 0.0004 0.0018 0.0025
Echinococcus granulosus solute carrier family 22 0.0004 0.0018 0.0027
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0756 0.5193 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0173 0.0333
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0003 0.0007 0.0004
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0148 0.0227
Trichomonas vaginalis myo-inositol transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Brugia malayi nuclear receptor NHR-67 0.0002 0.0002 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0005 0.0018 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0018 0.0035
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0003 0.0005 0.0001
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0003 0.0005 0.0009
Echinococcus multilocularis 0.0003 0.0005 0.0009
Leishmania major glucose transporter/membrane transporter D2, putative 0.0004 0.0018 0.0025
Echinococcus granulosus c src tyrosine kinase 0.0002 0.0002 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0003 0.0007 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0002 0.0003 0.0006
Trypanosoma cruzi hexose transporter, putative 0.0004 0.0018 0.0025
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0002 0.0002 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0005 0.0018 0.0112
Giardia lamblia Hexose transporter 0.0004 0.0018 0.003
Leishmania major glucose transporter, lmgt2 0.0004 0.0018 0.0025
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0053 0.0081
Brugia malayi ABC transporter transmembrane region family protein 0.0011 0.0064 0.0123
Brugia malayi ABC transporter family protein 0.0003 0.0005 0.0009
Loa Loa (eye worm) phospholipase/Carboxylesterase 0.0004 0.0014 0.0027
Brugia malayi ABC transporter family protein 0.0003 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0004 0.0018 0.0034
Brugia malayi hypothetical protein 0.0002 0.0002 0.0003
Onchocerca volvulus 0.0005 0.0018 0.0112
Onchocerca volvulus Protein ultraspiracle homolog 0.0005 0.0018 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Brugia malayi Nuclear hormone receptor E75 0.0002 0.0002 0.0003
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0148 0.0286
Brugia malayi hypothetical protein 0.0031 0.0203 0.039
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0148 0.0227
Trichomonas vaginalis glutaminase, putative 0.007 0.0468 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0005 0.0018 0.0035
Onchocerca volvulus 0.0131 0.089 0.6072
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0003 0.0007 0.0004
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.033 0.226 0.2256
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0004 0.0018 0.0013
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0053 0.0102
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Trypanosoma brucei THT1 - hexose transporter, putative 0.0004 0.0018 0.0025
Schistosoma mansoni multidrug resistance protein 0.0002 0.0004 0.0008
Onchocerca volvulus 0.0004 0.0018 0.0111
Entamoeba histolytica P-glyco protein 6, putative 0.0003 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Mycobacterium ulcerans sugar transporter 0.0004 0.0018 0.0013
Leishmania major hypothetical protein, conserved 0.0131 0.089 0.1706
Entamoeba histolytica P-glycoprotein 6, putative 0.0003 0.0005 0.0001
Leishmania major hypothetical protein, conserved 0.0004 0.0018 0.0025
Entamoeba histolytica P-glycoprotein-2 0.0003 0.0005 0.0001
Echinococcus multilocularis nuclear receptor nhr 48 0.0002 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0148 0.0278
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0756 0.5193 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0003 0.0005 0.0009
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0004 0.0018 0.0027
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0053 0.0102
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0756 0.5193 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0004 0.0018 1
Brugia malayi nuclear hormone receptor 0.0002 0.0002 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus granulosus thyroid hormone receptor alpha 0.0002 0.0002 0.0002
Brugia malayi hypothetical protein 0.0004 0.0018 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0215 0.1465 0.2815
Echinococcus granulosus Nuclear hormone receptor HR96 0.0002 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0286
Onchocerca volvulus Bile acid receptor homolog 0.0005 0.0018 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0131 0.089 0.1714
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0003 0.0005 0.0001
Chlamydia trachomatis lysophospholipase esterase 0.0004 0.0014 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0003 0.0005 0.0007
Brugia malayi beta-lactamase 0.0131 0.089 0.1714
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0004 0.0018 0.003
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus multilocularis synaptic vesicle 2 protein 0.0004 0.0018 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0027 0.0173 0.0333
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0018 0.0035
Trypanosoma brucei beta lactamase 0.0698 0.4793 0.923
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0005 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0286
Brugia malayi major facilitator superfamily protein 0.0004 0.0018 0.0034
Mycobacterium tuberculosis Conserved protein 0.0131 0.089 0.0886
Schistosoma mansoni hypothetical protein 0.0013 0.0078 0.015
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0698 0.4793 0.4791
Schistosoma mansoni nuclear hormone receptor 0.0002 0.0002 0.0003
Brugia malayi ABC transporter family protein 0.0003 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0018 0.0026
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0003 0.0005 0.0007
Onchocerca volvulus 0.0004 0.0018 0.0111
Brugia malayi Bloom's syndrome protein homolog 0.0005 0.0024 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Toxoplasma gondii sugar transporter ST2 0.0004 0.0018 0.003
Brugia malayi multidrug resistance protein 3 0.0003 0.0005 0.0009
Schistosoma mansoni nuclear receptor 0.0002 0.0002 0.0003
Brugia malayi Tyrosine-protein kinase abl-1 0.0002 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0003 0.0005 0.0009
Trichomonas vaginalis glucose transporter, putative 0.0004 0.0018 0.0026
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0011 0.0064 0.0114
Loa Loa (eye worm) hypothetical protein 0.0002 0.0003 0.0006
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0756 0.5193 0.7956
Echinococcus granulosus expressed protein 0.0457 0.3133 0.48
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0131 0.089 0.0886
Brugia malayi ABC transporter transmembrane region family protein 0.0002 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0003 0.0005 0.0001
Echinococcus granulosus bloom syndrome protein 0.0005 0.0024 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis glucose transporter, putative 0.0004 0.0018 0.0026
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0003 0.0005 0.0001
Brugia malayi hypothetical protein 0.0023 0.0148 0.0286
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0003 0.0005 0.0001
Leishmania major myo-inositol/proton symporter (MIT) 0.0004 0.0018 0.0025
Echinococcus multilocularis ATP binding cassette sub family B 0.0003 0.0005 0.0009
Schistosoma mansoni microtubule-associated protein tau 0.0396 0.2712 0.5223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0018 0.0028
Onchocerca volvulus 0.0004 0.0018 0.0111
Brugia malayi nuclear receptor RXR 0.0002 0.0003 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0131 0.089 0.1714
Trichomonas vaginalis taga, putative 0.0003 0.0005 0.0001
Brugia malayi P-glycoprotein-like protein 0.0003 0.0005 0.0009
Brugia malayi Major Facilitator Superfamily protein 0.0004 0.0018 0.0034
Schistosoma mansoni acyl-protein thioesterase 12 (lysophospholipase III) 0.0004 0.0014 0.0027
Brugia malayi orphan nuclear receptor NR2E1 0.0002 0.0002 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Leishmania major ABC-thiol transporter 0.0011 0.0064 0.0114
Schistosoma mansoni retinoic acid receptor RXR 0.0005 0.0018 0.0035
Brugia malayi tailless protein 0.0002 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0286
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0003 0.0005 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0053 0.0102
Brugia malayi glutaminase DH11.1 0.007 0.0468 0.0901
Trypanosoma brucei sugar transporter, putative 0.0004 0.0018 0.0025
Trypanosoma brucei glucose transporter 1E 0.0004 0.0018 0.0025
Leishmania major p-glycoprotein e 0.0011 0.0064 0.0114
Echinococcus multilocularis solute carrier family 22 0.0004 0.0018 0.0034
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0148 0.0286
Mycobacterium tuberculosis Probable lipase LipD 0.0131 0.089 0.0886
Onchocerca volvulus 0.0004 0.0018 0.0111
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0756 0.5193 1
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0005 0.0018 0.0035
Mycobacterium ulcerans hypothetical protein 0.0131 0.089 0.0886
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0698 0.4793 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0018 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0131 0.089 0.1706
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0122
Trichomonas vaginalis sugar transport protein, putative 0.0004 0.0018 0.0026
Schistosoma mansoni coup transcription factor 0.0005 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0286
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0002 0.0003 0.0006
Schistosoma mansoni zinc finger protein 0.0002 0.0002 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0131 0.089 0.0886
Trypanosoma brucei hypothetical protein, conserved 0.0131 0.089 0.1706
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0004 0.0018 0.0034
Giardia lamblia ABC transporter, putative 0.0011 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0148 0.0286
Loa Loa (eye worm) glutaminase 0.007 0.0468 0.0901
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0018 0.0035
Brugia malayi PXA domain containing protein 0.0023 0.0148 0.0286
Echinococcus granulosus tyrosine protein kinase Src42A 0.0008 0.0045 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0005 0.0018 0.0035
Entamoeba histolytica multidrug resistance protein, putative 0.0011 0.0064 0.0115
Echinococcus multilocularis c src tyrosine kinase 0.0002 0.0002 0.0004
Echinococcus multilocularis multidrug resistance protein 1 0.0003 0.0005 0.0009
Echinococcus granulosus multidrug resistance associated protein 1 0.0011 0.0064 0.0098
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0148 0.0286
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0053 0.0081
Loa Loa (eye worm) SRC-1 0.001 0.0053 0.0102
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0003 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0148 0.0278
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0003 0.0005 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0005 0.0018 0.0035
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0002 0.0002 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0005 0.0018 0.0035
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0148 0.0286
Loa Loa (eye worm) hypothetical protein 0.0002 0.0004 0.0008
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0003 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0027 0.0173 0.0333
Echinococcus granulosus ATP binding cassette sub family B 0.0003 0.0005 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0005 0.0018 0.0028
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0003 0.0005 0.0001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0002 0.0002 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0131 0.089 0.0886
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0148 0.0286
Echinococcus granulosus nuclear receptor nhr 48 0.0002 0.0002 0.0002
Toxoplasma gondii sugar transporter ST1 0.0004 0.0018 0.003
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Entamoeba histolytica P-glycoprotein 6, putative 0.0003 0.0005 0.0001
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0002 0.0002 0.0004
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0002 0.0002 0.0003
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0053 0.0081
Loa Loa (eye worm) hypothetical protein 0.0004 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0002 0.0002 0.0003
Trypanosoma brucei glucose transporter, putative 0.0004 0.0018 0.0025
Giardia lamblia Sugar-proton symporter 0.0004 0.0018 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.0005 0.0018 0.0035
Mycobacterium tuberculosis Probable lipase LipE 0.0131 0.089 0.0886
Schistosoma mansoni glucose transporter 0.0004 0.0018 0.0034
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0756 0.5193 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0003 0.0005 0.0005
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0002 0.0002 0.0004
Schistosoma mansoni blooms syndrome DNA helicase 0.0004 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0002 0.0003 0.0006
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0756 0.5193 1
Loa Loa (eye worm) hypothetical protein 0.0003 0.0005 0.0009
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0148 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0004 0.0018 0.0026
Echinococcus multilocularis ATP binding cassette sub family B 0.0003 0.0005 0.0009
Wolbachia endosymbiont of Brugia malayi esterase 0.0004 0.0014 0.7227
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0148 0.0286
Leishmania major lysophospholipase, putative 0.0004 0.0014 0.0018
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0148 0.0286
Loa Loa (eye worm) hypothetical protein 0.0131 0.089 0.1714
Trypanosoma cruzi hypothetical protein, conserved 0.0131 0.089 0.1706
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.0014 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0005 0.0018 0.0035
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0148 0.0286
Leishmania major glucose transporter, lmgt3 0.0004 0.0018 0.0025
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0004 0.0018 0.0034
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0148 0.0286
Trypanosoma cruzi hexose transporter 0.0004 0.0018 0.0025
Onchocerca volvulus 0.0004 0.0018 0.0111
Loa Loa (eye worm) DR-78 0.0002 0.0002 0.0003
Onchocerca volvulus Transmembrane 9 superfamily member 4 homolog 0.0004 0.0014 0.0086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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