TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.145 | Formula: C10H10AgN4O2S--
H donors: 2 H acceptors: 2 LogP: 1.95 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc(cc1)[S+]1(=O)O[Ag-4][n+]2c(N1)nccc2
InChi: 1S/C10H10N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2,(H-,12,13,14,15,16);/q;-2
InChiKey: PCGJLZKQEHCHRQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	alpha-L-fucosidase	0.0418	0.0308	1
Trichomonas vaginalis	glucosylceramidase, putative	0.5471	0.4246	0.6552
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.1351	0.1035	0.1597
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0153	0.0101	0.0109
Brugia malayi	MAP kinase sur-1	0.0043	0.0015	0.0015
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0111	0.0068	0.0105
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.013	0.0083	0.8758
Brugia malayi	Trehalase family protein	0.0128	0.0082	0.0082
Schistosoma mansoni	cpg binding protein	0.0032	0.0007	0.0008
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0145	0.0095	1
Trichomonas vaginalis	glucosylceramidase, putative	0.8339	0.6481	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0039	0.0137
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.0038	0.0038
Brugia malayi	Ceramide glucosyltransferase	0.7592	0.5898	0.5898
Onchocerca volvulus		0.9018	0.701	1
Echinococcus granulosus	tar DNA binding protein	0.0072	0.0038	0.0038
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.003	0.015
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0035	0.0114
Trypanosoma cruzi	hypothetical protein, conserved	0.2282	0.176	1
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0116	0.0073	0.0073
Treponema pallidum	hypothetical protein	0.0044	0.0017	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.5471	0.4246	0.6552
Schistosoma mansoni	hypothetical protein	0.0238	0.0168	0.018
Trichomonas vaginalis	CMGC family protein kinase	0.0043	0.0015	0.0023
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0145	0.0095	1
Trypanosoma brucei	glycosyl hydrolase-like protein	0.1351	0.1035	0.5845
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.2282	0.176	1
Loa Loa (eye worm)	trehalase	0.0044	0.0017	0.0017
Trichomonas vaginalis	amylase, putative	0.0028	0.0004	0.0006
Trichomonas vaginalis	CMGC family protein kinase	0.0043	0.0015	0.0023
Giardia lamblia	Ceramide glucosyltransferase	0.3441	0.2664	1
Entamoeba histolytica	alpha-amylase family protein	0.0028	0.0004	0.0021
Echinococcus multilocularis	beta galactosidase	0.0566	0.0423	0.0423
Chlamydia trachomatis	1,4-alpha-glucan branching enzyme	0.0028	0.0004	0.5
Brugia malayi	Alpha-L-fucosidase family protein	0.0253	0.0179	0.0179
Brugia malayi	Trehalase family protein	0.0128	0.0082	0.0082
Trichomonas vaginalis	glycoside hydrolase, putative	0.0413	0.0304	0.0469
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0039	0.3892
Schistosoma mansoni	alpha-l-fucosidase	0.0253	0.0179	0.0192
Trichomonas vaginalis	amylase, putative	0.0028	0.0004	0.0006
Loa Loa (eye worm)	beta-glucuronidase	0.0161	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0082	0.0082
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.013	0.0083	0.4908
Brugia malayi	RNA binding protein	0.0072	0.0038	0.0038
Echinococcus multilocularis	dnaJ subfamily B	0.0463	0.0342	0.0342
Trypanosoma cruzi	hypothetical protein, conserved	0.2282	0.176	1
Echinococcus multilocularis	bile acid beta glucosidase	0.7586	0.5894	0.5894
Loa Loa (eye worm)	hypothetical protein	0.085	0.0645	0.0645
Echinococcus granulosus	dnaJ subfamily B	0.0463	0.0342	0.0342
Trypanosoma brucei	trypanothione reductase	0.0057	0.0026	0.0065
Echinococcus multilocularis	glycogen debranching enzyme	0.033	0.0239	0.0239
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.0038	0.0038
Toxoplasma gondii	melibiase subfamily protein	0.0153	0.0101	0.0555
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0566	0.0423	0.0423
Echinococcus granulosus	glycogen debranching enzyme	0.033	0.0239	0.0239
Schistosoma mansoni	hypothetical protein	0.0424	0.0313	0.0336
Brugia malayi	Trehalase family protein	0.0044	0.0017	0.0017
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.013	0.0083	0.8758
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.0038	0.0038
Echinococcus multilocularis	alpha glucosidase	0.0116	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0017	0.0017
Echinococcus granulosus	mitogen activated protein kinase	0.0043	0.0015	0.0015
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.1351	0.1035	0.5845
Chlamydia trachomatis	glycogen hydrolase	0.0028	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0082	0.0082
Trichomonas vaginalis	glucosylceramidase, putative	0.5471	0.4246	0.6552
Trichomonas vaginalis	maltase-glucoamylase, putative	0.2282	0.176	0.2716
Schistosoma mansoni	alpha-glucosidase	1.1959	0.9302	1
Echinococcus granulosus	expressed protein	0.0451	0.0333	0.0333
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0057	0.0026	0.0026
Loa Loa (eye worm)	trehalase	0.0128	0.0082	0.0082
Onchocerca volvulus	Glucosylceramidase homolog	0.5471	0.4246	0.6053
Trichomonas vaginalis	glucosylceramidase, putative	0.5471	0.4246	0.6552
Schistosoma mansoni	bile acid beta-glucosidase-related	0.7586	0.5894	0.6336
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	1.2855	1	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.2282	0.176	1
Echinococcus multilocularis	lysosomal alpha glucosidase	1.2855	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.8339	0.6481	1
Brugia malayi	Trehalase protein 5	0.0044	0.0017	0.0017
Trichomonas vaginalis	alpha-glucosidase, putative	0.1351	0.1035	0.1597
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0013	0.0013
Echinococcus multilocularis	lysosomal alpha glucosidase	1.2855	1	1
Brugia malayi	TAR-binding protein	0.0072	0.0038	0.0038
Trichomonas vaginalis	Periplasmic beta-glucosidase precursor, putative	0.0039	0.0012	0.0019
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Brugia malayi	Melibiase family protein	0.0153	0.0101	0.0101
Trichomonas vaginalis	starch branching enzyme II, putative	0.0028	0.0004	0.0006
Entamoeba histolytica	alpha-amylase family protein	0.0028	0.0004	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0298	0.0214	0.0331
Trichomonas vaginalis	glucosylceramidase, putative	0.8339	0.6481	1
Brugia malayi	trehalase I	0.0044	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0017	0.0017
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.7592	0.5898	0.8412
Onchocerca volvulus		0.0128	0.0082	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0017	0.0017
Loa Loa (eye worm)	thioredoxin reductase	0.0057	0.0026	0.0026
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0043	0.0015	0.0015
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0039	0.0042
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0039	0.0042
Echinococcus granulosus	mitogen activated protein kinase 3	0.0043	0.0015	0.0015
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0028	0.0004	0.0021
Mycobacterium ulcerans	beta-glucosidase BglS	0.0039	0.0012	0.0278
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0153	0.0101	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0114	0.0176
Schistosoma mansoni	alpha-amylase	0.0116	0.0073	0.0078
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0068	0.0035	0.0199
Schistosoma mansoni	starch branching enzyme II	0.0028	0.0004	0.0004
Brugia malayi	1,4-alpha-glucan branching enzyme	0.0028	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0028	0.0004	0.0004
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.0418	0.0308	0.0308
Loa Loa (eye worm)	trehalase	0.0128	0.0082	0.0082
Trichomonas vaginalis	CMGC family protein kinase	0.0043	0.0015	0.0023
Echinococcus granulosus	beta galactosidase	0.0566	0.0423	0.0423
Trichomonas vaginalis	CMGC family protein kinase	0.0043	0.0015	0.0023
Echinococcus granulosus	non lysosomal glucosylceramidase	0.7586	0.5894	0.5894
Onchocerca volvulus		0.0128	0.0082	0.0107
Brugia malayi	hypothetical protein	0.0044	0.0017	0.0017
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Trichomonas vaginalis	alpha-glucosidase, putative	0.1351	0.1035	0.1597
Loa Loa (eye worm)	TRE-2 protein	0.0128	0.0082	0.0082
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0068	0.0035	0.0035
Schistosoma mansoni	ceramide glucosyltransferase	0.7592	0.5898	0.6341
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0013	0.0013
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.2282	0.176	0.2716
Schistosoma mansoni	alpha-amylase	0.0116	0.0073	0.0078
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0007	0.0007
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.2282	0.176	0.2716
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.1351	0.1035	0.1035
Loa Loa (eye worm)	hypothetical protein	0.512	0.3972	0.3972
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.2282	0.176	0.176
Schistosoma mansoni	ceramide glucosyltransferase	0.7592	0.5898	0.6341
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.0036	0.0038
Mycobacterium tuberculosis	Probable dehydrogenase	0.013	0.0083	0.8758
Entamoeba histolytica	alpha-amylase family protein	0.0028	0.0004	0.0021
Schistosoma mansoni	alpha-glucosidase	1.1959	0.9302	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0057	0.0026	0.2506
Loa Loa (eye worm)	trehalase	0.0044	0.0017	0.0017
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.013	0.0083	0.8758
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0153	0.0101	0.0109
Trichomonas vaginalis	sucrase-isomaltase, putative	0.2247	0.1733	0.2675
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.1351	0.1035	0.5881
Trichomonas vaginalis	alpha-glucosidase, putative	0.2282	0.176	0.2716
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0035	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0017	0.0017
Trichomonas vaginalis	beta-galactosidase, putative	0.0298	0.0214	0.0331
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Trichomonas vaginalis	glucosylceramidase, putative	0.5471	0.4246	0.6552
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0015	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0032	0.0032
Echinococcus granulosus	alpha glucosidase	0.0116	0.0073	0.0073
Trichomonas vaginalis	glucosylceramidase, putative	0.5766	0.4475	0.6906
Trichomonas vaginalis	amylase, putative	0.0028	0.0004	0.0006
Giardia lamblia	4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase	0.033	0.0239	0.0886
Trichomonas vaginalis	beta-mannosidase, putative	0.0097	0.0057	0.0089
Loa Loa (eye worm)	TRE-1 protein	0.0128	0.0082	0.0082
Echinococcus granulosus	beta D xylosidase 2	0.0039	0.0012	0.0012
Mycobacterium tuberculosis	Trehalose synthase TreS	0.0116	0.0073	0.756
Mycobacterium tuberculosis	Probable oxidoreductase	0.0145	0.0095	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0068	0.0035	0.0038
Loa Loa (eye worm)	alpha-L-fucosidase	0.0253	0.0179	0.0179
Brugia malayi	hypothetical protein	0.0044	0.0017	0.0017
Leishmania major	glycosyl hydrolase-like protein	0.1351	0.1035	0.5845
Brugia malayi	Glycosyl hydrolases family 31 protein	0.2282	0.176	0.176
Brugia malayi	Trehalase family protein	0.0044	0.0017	0.0017
Loa Loa (eye worm)	alpha amylase	0.0116	0.0073	0.0073
Trichomonas vaginalis	alpha-glucosidase, putative	0.1351	0.1035	0.1597
Trypanosoma brucei	glucosidase, putative	0.2282	0.176	1
Trichomonas vaginalis	glycoside hydrolases, putative	0.0176	0.0119	0.0184
Schistosoma mansoni	hypothetical protein	0.022	0.0153	0.0165
Trichomonas vaginalis	glucosylceramidase, putative	0.5766	0.4475	0.6906
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0038	0.0041
Entamoeba histolytica	oligo-1,6-glucosidase, putative	0.0116	0.0073	0.0412
Toxoplasma gondii	thioredoxin reductase	0.0057	0.0026	0.013
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.033	0.0239	0.0369
Echinococcus multilocularis	beta D xylosidase 2	0.0039	0.0012	0.0012
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.033	0.0239	0.0239
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.013	0.0083	0.8758
Schistosoma mansoni	beta-galactosidase	0.0566	0.0423	0.0455
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0068	0.0035	0.0035
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0035	0.0114
Onchocerca volvulus		0.0128	0.0082	0.0107
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0039	0.1168
Echinococcus granulosus	neutral alpha glucosidase AB	0.2282	0.176	0.176
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0038	0.0041
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0039	0.0039
Brugia malayi	Glycosyl hydrolases family 31 protein	0.1351	0.1035	0.1035
Mycobacterium tuberculosis	Probable reductase	0.013	0.0083	0.8758
Onchocerca volvulus		0.0128	0.0082	0.0107
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0173	0.0117	1
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0111	0.0068	0.0105
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0043	0.0015	0.0066
Trichomonas vaginalis	glucosylceramidase, putative	0.8339	0.6481	1
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0153	0.0101	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.0082	0.0126
Brugia malayi	trehalase	0.0044	0.0017	0.0017
Trypanosoma brucei	RNA helicase, putative	0.0218	0.0152	0.0782
Trichomonas vaginalis	glucosylceramidase, putative	0.5471	0.4246	0.6552
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0101	0.0101
Loa Loa (eye worm)	trehalase	0.0128	0.0082	0.0082
Trichomonas vaginalis	trehalase, putative	0.0128	0.0082	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0004	0.0004
Trichomonas vaginalis	beta-glucosidase, putative	0.0176	0.0119	0.0184
Echinococcus multilocularis	cpg binding protein	0.0034	0.0009	0.0009
Schistosoma mansoni	beta-mannosidase	0.0097	0.0057	0.0062
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Schistosoma mansoni	alpha-amylase	0.0116	0.0073	0.0078
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.8339	0.6481	0.6481
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0153	0.0101	0.0101
Onchocerca volvulus		0.0128	0.0082	0.0107
Trichomonas vaginalis	alpha-glucosidase, putative	0.2282	0.176	0.2716
Trichomonas vaginalis	glucosylceramidase, putative	0.5471	0.4246	0.6552
Entamoeba histolytica	beta-galactosidase, putative	0.0202	0.0139	0.079
Echinococcus granulosus	bile acid beta glucosidase	0.7586	0.5894	0.5894
Trichomonas vaginalis	glucosylceramidase, putative	0.8339	0.6481	1
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0004	0.0006
Entamoeba histolytica	glycogen debranching enzyme, putative	0.033	0.0239	0.1359
Echinococcus granulosus	trehalose 6 phosphate hydrolase	0.0028	0.0004	0.0004
Toxoplasma gondii	Amylo-alpha-1,6-glucosidase	0.033	0.0239	0.1341
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0039	0.0202
Schistosoma mansoni	alpha-amylase	0.0116	0.0073	0.0078
Trichomonas vaginalis	glucosylceramidase, putative	0.8339	0.6481	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.2247	0.1733	0.9846
Giardia lamblia	Kinase, CMGC MAPK	0.0043	0.0015	0.0044
Schistosoma mansoni	hypothetical protein	0.0218	0.0152	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0047	0.0047
Entamoeba histolytica	alpha-amylase family protein	0.0028	0.0004	0.0021
Brugia malayi	hypothetical protein	0.0044	0.0017	0.0017
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0116	0.0073	0.0073
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0038	0.0041
Schistosoma mansoni	alpha-amylase	0.0116	0.0073	0.0078
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Trichomonas vaginalis	alpha-glucosidase, putative	0.2282	0.176	0.2716
Entamoeba histolytica	hypothetical protein	0.0028	0.0004	0.0021
Brugia malayi	manba-prov protein	0.0097	0.0057	0.0057
Trichomonas vaginalis	alpha-glucosidase, putative	0.1351	0.1035	0.1597
Loa Loa (eye worm)	hypothetical protein	0.033	0.0239	0.0239
Schistosoma mansoni	alpha glucosidase	0.2282	0.176	0.1892
Echinococcus multilocularis	expressed protein	0.0451	0.0333	0.0333
Loa Loa (eye worm)	alpha amylase	0.0116	0.0073	0.0073
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.0418	0.0308	0.0308
Echinococcus multilocularis	mitogen activated protein kinase	0.0043	0.0015	0.0015
Loa Loa (eye worm)	RNA binding protein	0.0072	0.0038	0.0038
Onchocerca volvulus	Trehalase homolog	0.0128	0.0082	0.0107
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Entamoeba histolytica	alpha-amylase, putative	0.0028	0.0004	0.0021
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0169	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0082	0.0082
Brugia malayi	Beta-glucuronidase precursor	0.0161	0.0107	0.0107
Echinococcus granulosus	cpg binding protein	0.0034	0.0009	0.0009
Schistosoma mansoni	cpg binding protein	0.0034	0.0009	0.0009
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0068	0.0035	0.0114
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0028	0.0004	0.0021
Brugia malayi	Trehalase family protein	0.0128	0.0082	0.0082
Brugia malayi	Trehalase family protein	0.0128	0.0082	0.0082
Leishmania major	alpha glucosidase II subunit, putative	0.2282	0.176	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0068	0.0035	0.0035
Brugia malayi	hypothetical protein	0.0074	0.004	0.004
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.7586	0.5894	0.5894
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.033	0.0239	0.0369
Schistosoma mansoni	cpg binding protein	0.0034	0.0009	0.0009
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0038	0.0041
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0039	0.1168
Mycobacterium tuberculosis	Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas	0.0116	0.0073	0.756
Loa Loa (eye worm)	ceramide glucosyltransferase	0.7592	0.5898	0.5898
Entamoeba histolytica	hypothetical protein	0.0039	0.0012	0.0069
Trichomonas vaginalis	amylase, putative	0.0028	0.0004	0.0006
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0153	0.0101	0.0109
Echinococcus multilocularis	neutral alpha glucosidase AB	0.2282	0.176	0.176
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.0038	0.0041
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0145	0.0095	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.8339	0.6481	0.6481
Loa Loa (eye worm)	glutathione reductase	0.0057	0.0026	0.0026
Echinococcus multilocularis	ceramide glucosyltransferase	0.7592	0.5898	0.5898
Trypanosoma cruzi	trypanothione reductase, putative	0.0057	0.0026	0.0065
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0007	0.0007
Schistosoma mansoni	bile acid beta-glucosidase-related	0.7586	0.5894	0.6336
Trichomonas vaginalis	alpha-glucosidase, putative	0.2282	0.176	0.2716
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.1351	0.1035	0.5845
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0043	0.0015	0.0015
Echinococcus granulosus	lysosomal alpha glucosidase	1.2855	1	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0082	0.0082
Schistosoma mansoni	hypothetical protein	0.0039	0.0012	0.0013
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0068	0.0035	0.0035
Echinococcus multilocularis	trehalose 6 phosphate hydrolase	0.0028	0.0004	0.0004
Echinococcus granulosus	ceramide glucosyltransferase	0.7592	0.5898	0.5898
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0153	0.0101	0.0109
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0153	0.0101	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0082	0.0082
Echinococcus granulosus	glucan 14 alpha branching enzyme 1	0.0028	0.0004	0.0004
Entamoeba histolytica	alpha-amylase, putative	0.0028	0.0004	0.0021
Mycobacterium ulcerans	trehalose synthase TreS	0.0116	0.0073	0.2268
Trichomonas vaginalis	maltase-glucoamylase, putative	0.1351	0.1035	0.1597
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.0038	0.0038
Echinococcus granulosus	thioredoxin glutathione reductase	0.0057	0.0026	0.0026
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.1351	0.1035	0.1597
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.1351	0.1035	0.1468
Brugia malayi	Thioredoxin reductase	0.0057	0.0026	0.0026
Brugia malayi	hypothetical protein	0.0128	0.0082	0.0082
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0153	0.0101	0.0109
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0153	0.0101	0.0101
Leishmania major	trypanothione reductase	0.0057	0.0026	0.0065
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0039	0.0039
Entamoeba histolytica	beta/alpha-amylase precursor, putative	0.0028	0.0004	0.0021
Loa Loa (eye worm)	amylo-alpha-1,6-glucosidase	0.0161	0.0107	0.0107
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0169	0.0113	0.0113
Brugia malayi	glutathione reductase	0.0057	0.0026	0.0026
Plasmodium vivax	hypothetical protein, conserved	0.0173	0.0117	1
Schistosoma mansoni	hypothetical protein	0.0463	0.0342	0.0368
Echinococcus multilocularis	glucan (1,4 alpha), branching enzyme 1	0.0028	0.0004	0.0004
Trichomonas vaginalis	alpha-glucosidase, putative	0.2282	0.176	0.2716
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0039	0.1168
Trichomonas vaginalis	alpha-glucosidase, putative	0.1351	0.1035	0.1597
Trichomonas vaginalis	alpha-amylase, putative	0.0028	0.0004	0.0006

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3546122

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2072983