Detailed information for compound 2075146

Basic information

Technical information
  • TDR Targets ID: 2075146
  • Name: (1R)-1-[(2S)-6-fluorochroman-2-yl]-2-[[(2R)-2 -[(2S)-6-fluorochroman-2-yl]-2-hydroxyethyl]a mino]ethanol
  • MW: 405.435 | Formula: C22H25F2NO4
  • H donors: 3 H acceptors: 2 LogP: 3.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]([C@@H]1CCc2c(O1)ccc(c2)F)CNC[C@H]([C@H]1CCc2c(O1)ccc(c2)F)O
  • InChi: 1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/m1/s1
  • InChiKey: KOHIRBRYDXPAMZ-YHBROIRLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1R)-1-[(2S)-6-fluorochroman-2-yl]-2-[[(2R)-2-[(2S)-6-fluorochroman-2-yl]-2-hydroxy-ethyl]amino]ethanol
  • (1R)-1-[(2S)-6-fluoro-2-chromanyl]-2-[[(2R)-2-[(2S)-6-fluoro-2-chromanyl]-2-hydroxyethyl]amino]ethanol
  • 118457-15-1
  • Bystolic
  • Lobivon
  • ME-3255
  • Nebilet
  • R-65824
  • R-67138
  • R-67145
  • R-67555
  • Silostar

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0076 0.0258 0.0258
Brugia malayi N-terminal motif family protein 0.0214 0.0911 0.3413
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0072 0.0226
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0162 0.0567
Echinococcus multilocularis GPCR, family 2 0.0049 0.0129 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0218 0.0209
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0218 0.0218
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0134
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.0195 0.0823 0.0823
Trypanosoma brucei DNA polymerase IV, putative 0.0134 0.0533 0.3405
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.1546 1
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0678 0.4349
Trypanosoma brucei phosphoglycerate kinase 0.0196 0.0827 0.5318
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0418 0.1877 0.1877
Loa Loa (eye worm) hypothetical protein 0.0214 0.0911 0.3443
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0118 0.0109
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0071 0.0235 0.1471
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0147
Schistosoma mansoni DNA polymerase eta 0.0105 0.0397 0.0397
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0258 0.0636
Onchocerca volvulus 0.0096 0.0352 0.1259
Schistosoma mansoni rab6-interacting 0.004 0.0086 0.0086
Schistosoma mansoni lamin 0.0056 0.0162 0.0162
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0118 0.0109
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Trichomonas vaginalis rotamase, putative 0.0039 0.008 0.0174
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0148 0.0905
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0086 0.0938
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0324
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0072 0.0238 0.1492
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.001 0.001
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0145 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0068 0.0382
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0206 0.2406
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0324
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0083 0.0291 0.0281
Echinococcus granulosus lamin dm0 0.0056 0.0162 0.0152
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Trypanosoma cruzi DNA polymerase eta, putative 0.0105 0.0397 0.2521
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0116 0.0295
Echinococcus multilocularis dna polymerase kappa 0.0134 0.0533 0.0524
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0108 0.0407 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0155 0.0427
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0012 0.0003
Echinococcus multilocularis lamin 0.0056 0.0162 0.0152
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Loa Loa (eye worm) pre-B cell enhancing factor 0.0418 0.1877 0.7096
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0086 0.0076
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0415 0.2642
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0415 0.1538
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0072 0.0147
Schistosoma mansoni rotamase 0.0039 0.008 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0028 0.0028
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0229 0.2688
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0415 0.2642
Brugia malayi Pre-SET motif family protein 0.0454 0.2049 0.7732
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0097 0.0355 0.0346
Schistosoma mansoni intermediate filament proteins 0.0056 0.0162 0.0162
Brugia malayi hypothetical protein 0.004 0.0086 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Loa Loa (eye worm) hypothetical protein 0.0045 0.011 0.0414
Onchocerca volvulus 0.004 0.0086 0.0094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0683 0.2582
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0127 0.0273
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0145 0.0135
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0129 0.0781
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Leishmania major calcium channel protein, putative,ion transporter, putative 0.006 0.018 0.1108
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0076 0.0067
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0229 0.1197
Giardia lamblia Kinase, PLK 0.0109 0.0415 0.1358
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0012 0.0003
Trichomonas vaginalis chromobox protein, putative 0.008 0.0278 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Trypanosoma brucei unspecified product 0.0052 0.0146 0.0889
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.013 0.0447
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0036 0.0068 0.0223
Schistosoma mansoni polycystin 1-related 0.004 0.0086 0.0086
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0116 0.0295
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Mycobacterium ulcerans DNA polymerase IV 0.0134 0.0533 0.1985
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0145 0.0145
Schistosoma mansoni lamin 0.0056 0.0162 0.0162
Loa Loa (eye worm) doublecortin family protein 0.004 0.0086 0.0324
Trypanosoma brucei unspecified product 0.0052 0.0146 0.0889
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.1546 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0206 0.0206
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0942
Schistosoma mansoni hypothetical protein 0.0053 0.0149 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0407 0.0398
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0194 0.0185
Schistosoma mansoni alpha-glucosidase 0.0143 0.0574 0.0574
Echinococcus granulosus histone lysine methyltransferase setb 0.0083 0.0291 0.0281
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0047 0.0134
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0012 0.0046
Plasmodium falciparum M17 leucyl aminopeptidase 0.0122 0.0474 0.5681
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0072 0.0062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0291 0.1099
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.0258 0.0258
Loa Loa (eye worm) glutaminase 0.058 0.2646 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0075 0.0431
Entamoeba histolytica phosphoglycerate kinase, putative 0.0196 0.0827 0.2579
Echinococcus granulosus expressed protein 0.0039 0.008 0.007
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0012 0.0012
Toxoplasma gondii leucyl aminopeptidase LAP 0.0122 0.0474 0.5681
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0076 0.0258 0.0248
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0232 0.1447
Echinococcus granulosus neuropeptide s receptor 0.0463 0.2089 0.2081
Entamoeba histolytica deoxycytidyl transferase, putative 0.0076 0.0258 0.0635
Mycobacterium ulcerans beta-lactamase 0.0036 0.0068 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0415 0.0415
Echinococcus granulosus phosphoglycerate kinase 1 0.0196 0.0827 0.0818
Mycobacterium ulcerans leucyl aminopeptidase 0.0122 0.0474 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.008 0.0174
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0232 0.0844
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0278 0.105
Plasmodium falciparum phosphoglycerate kinase 0.0196 0.0827 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0145 0.0882
Trypanosoma brucei phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0118 0.0402
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0075 0.0431
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0122 0.0474 0.3021
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0063 0.0197 0.0703
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0075 0.0431
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1038 0.1029
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0198 0.0837 0.3133
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0232 0.0844
Loa Loa (eye worm) hypothetical protein 0.0108 0.0407 0.154
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0229 0.0229
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0028 0.0028 0.0019
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0106 0.0097
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0028 0.0028 0.0019
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.0659
Brugia malayi Muscleblind-like protein 0.0172 0.0713 0.2661
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0162 0.0611
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0145 0.0882
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0655 0.2999 1
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0326 0.206
Trypanosoma brucei DNA polymerase eta, putative 0.0105 0.0397 0.2521
Mycobacterium ulcerans phosphoglycerate kinase 0.0196 0.0827 0.31
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0068 0.0212
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0009 0.0009
Plasmodium vivax phosphoglycerate kinase, putative 0.0196 0.0827 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0415 0.0406
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0047 0.0038
Schistosoma mansoni rab6-interacting 0.004 0.0086 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0678 0.4349
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0122 0.0474 0.5681
Toxoplasma gondii ABC1 family protein 0.0036 0.0068 0.0719
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0063 0.0197 0.0188
Loa Loa (eye worm) hypothetical protein 0.0105 0.0397 0.15
Brugia malayi Phosphoglycerate kinase 0.0196 0.0827 0.3093
Loa Loa (eye worm) hypothetical protein 0.0198 0.0837 0.3165
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0145 0.0882
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0196 0.0827 1
Brugia malayi Pre-B cell enhancing factor precursor 0.0418 0.1877 0.7082
Echinococcus granulosus Solute carrier family 22 5 0.125 0.5818 0.5814
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0326 0.1918
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0228 0.0862
Plasmodium vivax SET domain protein, putative 0.0065 0.0206 0.2406
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0078 0.0268 0.0268
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0238 0.1025 0.1017
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.1546 1
Brugia malayi jmjC domain containing protein 0.007 0.0228 0.0819
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0172 0.0713 0.2695
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0111 0.0278
Echinococcus granulosus sodium channel protein 0.006 0.018 0.017
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0145 0.0882
Trichomonas vaginalis chromobox protein, putative 0.008 0.0278 0.0841
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0072 0.0147
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0028 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Schistosoma mansoni hypothetical protein 0.004 0.0086 0.0086
Brugia malayi intermediate filament protein 0.0056 0.0162 0.0567
Schistosoma mansoni alpha glucosidase 0.0037 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0111 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0407
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0072 0.0062
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0326 0.206
Schistosoma mansoni lipoxygenase 0.0166 0.0686 0.0686
Schistosoma mansoni survival motor neuron protein 0.0049 0.013 0.013
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0072 0.0765
Onchocerca volvulus 0.0056 0.0162 0.0426
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0086 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0196 0.0827 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0068 0.0257
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.0464 0.2961
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0134
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0122 0.0474 0.3021
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0258 0.0249
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0258 0.1411
Leishmania major DNA polymerase kappa, putative 0.009 0.0326 0.206
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.063 0.238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0076
Brugia malayi polk-prov protein 0.0082 0.0284 0.1032
Brugia malayi Heterochromatin protein 1 0.008 0.0278 0.1008
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0415 0.1531
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0238 0.1025 0.1017
Echinococcus multilocularis dna polymerase eta 0.0105 0.0397 0.0388
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0118 0.0446
Mycobacterium ulcerans DNA polymerase IV 0.0134 0.0533 0.1985
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0028 0.0028 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.0217 0.0217
Echinococcus multilocularis leucine aminopeptidase protein 0.0122 0.0474 0.0465
Leishmania major hypothetical protein, conserved 0.0036 0.0068 0.0382
Loa Loa (eye worm) hypothetical protein 0.0055 0.0157 0.0592
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.0183 0.0766 0.287
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.032 0.1412 0.5322
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0232 0.0222
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.008 0.0256
Echinococcus granulosus dna polymerase eta 0.0105 0.0397 0.0388
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.018 0.1111
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0229 0.1429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.063 0.2345
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0068 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Echinococcus multilocularis muscleblind protein 0.0172 0.0713 0.0704
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0078 0.0265 0.0265
Echinococcus granulosus intermediate filament protein 0.0056 0.0162 0.0152
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0258 0.0932
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0284 0.1788
Brugia malayi Doublecortin family protein 0.004 0.0086 0.028
Loa Loa (eye worm) hypothetical protein 0.0106 0.0398 0.1504
Loa Loa (eye worm) calcium channel 0.0108 0.0407 0.154
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0072 0.0271
Schistosoma mansoni glutaminase 0.058 0.2646 0.2646
Brugia malayi MAP kinase sur-1 0.0052 0.0145 0.0503
Echinococcus granulosus leucine aminopeptidase protein 0.0122 0.0474 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.0196 0.0827 0.3124
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0258 0.1617
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0147
Brugia malayi chromobox protein homolog 3 0.0045 0.0111 0.0374
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0047 0.0038
Schistosoma mansoni voltage-gated cation channel 0.0108 0.0407 0.0407
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Onchocerca volvulus 0.0049 0.013 0.0287
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Loa Loa (eye worm) glutaminase 2 0.058 0.2646 1
Onchocerca volvulus 0.0036 0.0068 0.0015
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0038 0.0077 0.0834
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0106 0.0097
Schistosoma mansoni hypothetical protein 0.0106 0.0398 0.0398
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0407 0.0398
Schistosoma mansoni kinase 0.0056 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0049 0.013 0.013
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0127 0.0332
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0028 0.0028
Mycobacterium ulcerans ion transport protein 0.0093 0.0336 0.1241
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.008 0.0301
Mycobacterium ulcerans lipase LipD 0.0036 0.0068 0.0223
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0683 0.2547
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0407 0.0398
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0086 0.0076
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0108 0.0407 0.0407
Echinococcus multilocularis geminin 0.0195 0.0823 0.0814
Trypanosoma brucei unspecified product 0.012 0.0464 0.2961
Schistosoma mansoni bromodomain containing protein 0.0066 0.0212 0.0212
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0134 0.0533 0.1698
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Leishmania major DNA polymerase eta, putative 0.0105 0.0397 0.2521
Echinococcus granulosus lamin 0.0056 0.0162 0.0152
Trichomonas vaginalis DNA polymerase eta, putative 0.0134 0.0533 0.1698
Schistosoma mansoni hypothetical protein 0.0195 0.0823 0.0823
Loa Loa (eye worm) hypothetical protein 0.0241 0.1038 0.3922
Echinococcus granulosus geminin 0.0195 0.0823 0.0814
Trichomonas vaginalis set domain proteins, putative 0.0517 0.2346 0.7801
Brugia malayi Pre-SET motif family protein 0.0065 0.0206 0.0736
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0196 0.0827 0.5318
Treponema pallidum phosphoglycerate kinase 0.0196 0.0827 0.2056
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0145 0.0547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0053 0.0148 0.1702
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0232 0.1218
Loa Loa (eye worm) hypothetical protein 0.0155 0.063 0.238
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Giardia lamblia Phosphoglycerate kinase 0.0196 0.0827 0.2734
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0108 0.0407 0.0398
Trypanosoma brucei DNA polymerase IV, putative 0.0134 0.0533 0.3405
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0195 0.0185
Onchocerca volvulus 0.0056 0.0162 0.0426
Echinococcus granulosus dna polymerase kappa 0.0134 0.0533 0.0524
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0028 0.0106
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0078 0.0265 0.0265
Onchocerca volvulus 0.0078 0.0268 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0407 0.0398
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0108 0.0407 0.1501
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0025 0.0015
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0415 0.2642
Treponema pallidum fructose-bisphosphate aldolase 0.0655 0.2999 1
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0122 0.0474 0.3021
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0382
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0028 0.0106
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0047 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) voltage-dependent calcium channel 0.0034 0.006 0.0226
Trypanosoma brucei phosphoglycerate kinase 0.0072 0.0238 0.1492
Leishmania major phosphoglycerate kinase C, glycosomal 0.0196 0.0827 0.5318
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0086 0.0938
Giardia lamblia Fructose-bisphosphate aldolase 0.0655 0.2999 1
Brugia malayi Bromodomain containing protein 0.004 0.0088 0.0288
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.3124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0118 0.0109
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0226
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0129 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0047 0.0038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0111 0.0418
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0145 0.0882
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0244
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0189 0.0716
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0415 0.1174
Chlamydia trachomatis phosphoglycerate kinase 0.0196 0.0827 1
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0122 0.0474 0.3017
Schistosoma mansoni phosphoglycerate kinase 0.0196 0.0827 0.0827
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0012 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0076 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Brugia malayi Cyclic-nucleotide gated cation channel 0.0028 0.0028 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus multilocularis lamin dm0 0.0056 0.0162 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0196 0.0827 0.2688
Schistosoma mansoni loxhd1 0.004 0.0086 0.0086
Onchocerca volvulus 0.0036 0.0068 0.0015
Echinococcus granulosus RUN 0.004 0.0086 0.0076
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.0418 0.1877 0.187
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0086 0.0076
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0068
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0852 0.3933 0.3927
Echinococcus multilocularis chromobox protein 1 0.008 0.0278 0.0269
Echinococcus multilocularis expressed protein 0.0039 0.008 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0194 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0048 0.0068
Brugia malayi hypothetical protein 0.004 0.0086 0.028
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Loa Loa (eye worm) hypothetical protein 0.0053 0.0148 0.056
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0228 0.0228
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0141 0.0564 0.2094
Mycobacterium ulcerans glutaminase 0.058 0.2646 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0075 0.0431
Leishmania major phosphoglycerate kinase B, cytosolic 0.0196 0.0827 0.5318
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.0407 0.0398
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.2089 0.2081
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0196 0.0827 0.5643
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0068 0.0223
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0145 0.0135
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0129 0.012
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0218 0.0209
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0068 0.0223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0118 0.0109
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0415 0.157
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0039 0.0101
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.2089 0.2081
Echinococcus multilocularis phosphoglycerate kinase 1 0.0196 0.0827 0.0818
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0229 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Onchocerca volvulus 0.0036 0.0068 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0291 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0382
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0756 0.245
Trypanosoma brucei glucosidase, putative 0.0037 0.0072 0.0407
Onchocerca volvulus 0.004 0.0086 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0291 0.0291
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0129 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Echinococcus multilocularis sodium channel protein 0.0097 0.0355 0.0346
Loa Loa (eye worm) hypothetical protein 0.0056 0.0162 0.0611
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0122 0.0474 0.3017
Brugia malayi Bromodomain containing protein 0.0079 0.0271 0.0981
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0012 0.002
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0086 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0454 0.2049 0.7743
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0214 0.0911 0.371
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0078 0.0265 0.1462
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0407 0.0398
Trypanosoma brucei protein kinase, putative 0.0052 0.0145 0.0882
Echinococcus multilocularis chromobox protein 1 0.008 0.0278 0.0269
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0047 0.0038
Brugia malayi jmjC domain containing protein 0.0068 0.0218 0.0783
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0334
Loa Loa (eye worm) hypothetical protein 0.0043 0.01 0.0378
Schistosoma mansoni microtubule-associated protein tau 0.2133 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.0987 0.6839
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0145 0.1658
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0086 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0196 0.0827 0.5318
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0232 0.0222
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0258 0.0974
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0145 0.0882
Leishmania major DNA polymerase eta, putative 0.0053 0.0148 0.0905
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0162 0.0611
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0678 0.4349
Brugia malayi PHD-finger family protein 0.0026 0.0021 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0076 0.0258 0.0248
Brugia malayi hypothetical protein 0.0241 0.1038 0.3894
Trichomonas vaginalis rotamase, putative 0.0038 0.0075 0.016
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.006 0.062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0212
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Schistosoma mansoni alpha-glucosidase 0.0143 0.0574 0.0574
Trichomonas vaginalis glutaminase, putative 0.058 0.2646 0.8811
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0129 0.0444
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0228 0.0219
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0071 0.0235 0.1471
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0155 0.0427
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0145 0.0882
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0129 0.012
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0228 0.0228
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Echinococcus granulosus chromobox protein 1 0.008 0.0278 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0048 0.0068
Giardia lamblia DINP protein human, muc B family 0.009 0.0326 0.1059
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0106
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0039 0.0147
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0076
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.006 0.005
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0127 0.0332
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0196 0.0827 1
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0047 0.0047
Echinococcus granulosus GPCR family 2 0.0049 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0488
Toxoplasma gondii hypothetical protein 0.0056 0.0163 0.1886
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0012 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1038 0.1029
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.0418 0.1877 0.187
Echinococcus multilocularis RUN 0.004 0.0086 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0068
Schistosoma mansoni chromobox protein 0.008 0.0278 0.0278
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0068 0.0719
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0141 0.0564 0.0564
Echinococcus multilocularis muscleblind protein 1 0.0172 0.0713 0.0704
Echinococcus granulosus muscleblind protein 0.0172 0.0713 0.0704
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0078 0.0265 0.1462
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0129 0.0488
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0122 0.0474 0.3021
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0063 0.0197 0.0188
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0141 0.0564 0.0555
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0229 0.0229
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0258 0.0933
Trichomonas vaginalis esterase, putative 0.0036 0.0068 0.0134
Onchocerca volvulus 0.0517 0.2346 1
Schistosoma mansoni lipoxygenase 0.0238 0.1025 0.1025
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0145 0.0135
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0094
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Echinococcus multilocularis microtubule associated protein 2 0.2133 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0398 0.1465
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0111 0.0202
Schistosoma mansoni phosphoglycerate kinase 0.0196 0.0827 0.0827
Brugia malayi beta-lactamase 0.0036 0.0068 0.0212
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0063 0.0197 0.0745
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.2089 0.2081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0068 0.0059
Echinococcus granulosus chromobox protein 1 0.008 0.0278 0.0269
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Brugia malayi Phosphoglycerate kinase 0.0072 0.0238 0.0859
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0258 0.0249
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0232 0.0833
Brugia malayi ImpB/MucB/SamB family protein 0.0105 0.0397 0.146
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0212
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0075 0.081
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Schistosoma mansoni chromobox protein 0.008 0.0278 0.0278
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0206 0.0197
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0415 0.0406
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0076 0.0258 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0284 0.1788
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0196 0.0827 0.2688
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.032 0.1412 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0196 0.0827 0.5643
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0108 0.0407 0.0398
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0179
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0141 0.0564 0.0555
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0258 0.0258
Trypanosoma brucei polo-like protein kinase 0.0109 0.0415 0.2642
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0072 0.0407
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0145 0.0135
Loa Loa (eye worm) voltage-gated potassium channel 0.0123 0.0482 0.1822
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0129 0.0444
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.063 0.2345
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.1546 1
Echinococcus multilocularis musashi 0.0056 0.0162 0.0152
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0407 0.0398
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0229 0.022
Loa Loa (eye worm) beta-lactamase 0.0036 0.0068 0.0257
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0218 0.0209
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.032 0.1412 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0284 0.1073
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.0796
Trypanosoma brucei phosphoglycerate kinase 0.0196 0.0827 0.5318
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0108 0.0407 0.0398
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0075 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Brugia malayi glutaminase DH11.1 0.058 0.2646 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.0766 0.5192
Loa Loa (eye worm) hypothetical protein 0.0172 0.0713 0.2695

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.