Detailed information for compound 207649

Basic information

Technical information
  • TDR Targets ID: 207649
  • Name: (2-propan-2-yl-1,3-thiazol-4-yl)methyl N-[(2S )-1-[[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl) -4-(pyridin-4-ylmethyl)piperazin-1-yl]-3-hydr oxy-1-phenylbutan-2-yl]amino]-3-methyl-1-oxob utan-2-yl]carbamate
  • MW: 721.952 | Formula: C38H55N7O5S
  • H donors: 4 H acceptors: 6 LogP: 4.42 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(=O)N[C@H]([C@@H](CN1CCN(C[C@H]1C(=O)NC(C)(C)C)Cc1ccncc1)O)Cc1ccccc1)C(C)C)OCc1csc(n1)C(C)C
  • InChi: 1S/C38H55N7O5S/c1-25(2)33(42-37(49)50-23-29-24-51-36(40-29)26(3)4)35(48)41-30(19-27-11-9-8-10-12-27)32(46)22-45-18-17-44(20-28-13-15-39-16-14-28)21-31(45)34(47)43-38(5,6)7/h8-16,24-26,30-33,46H,17-23H2,1-7H3,(H,41,48)(H,42,49)(H,43,47)/t30-,31-,32+,33-/m0/s1
  • InChiKey: VZZNYJBSHYEULF-SSNHPIBPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-isopropylthiazol-4-yl)methyl N-[(1S)-1-[[(1S,2R)-1-benzyl-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazin-1-yl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamate
  • N-[(1S)-1-[[[(1S,2R)-1-benzyl-3-[(2S)-2-[(tert-butylamino)-oxomethyl]-4-(4-pyridylmethyl)-1-piperazinyl]-2-hydroxypropyl]amino]-oxomethyl]-2-methylpropyl]carbamic acid (2-isopropyl-4-thiazolyl)methyl ester
  • (2-propan-2-yl-1,3-thiazol-4-yl)methyl N-[(2S)-1-[[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-(pyridin-4-ylmethyl)piperazin-1-yl]-3-hydroxy-1-phenyl-butan-2-yl]amino]-3-methyl-1-oxo-butan-2-yl]carbamate
  • N-[(1S)-1-[[(1S,2R)-1-benzyl-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazino]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamic acid (2-isopropylthiazol-4-yl)methyl ester
  • (2-isopropylthiazol-4-yl)methyl N-[(1S)-1-[[(1S,2R)-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazin-1-yl]-2-hydroxy-1-(phenylmethyl)propyl]carbamoyl]-2-methyl-propyl]carbamate
  • N-[(1S)-1-[[[(1S,2R)-3-[(2S)-2-[(tert-butylamino)-oxomethyl]-4-(4-pyridylmethyl)-1-piperazinyl]-2-hydroxy-1-(phenylmethyl)propyl]amino]-oxomethyl]-2-methylpropyl]carbamic acid (2-isopropyl-4-thiazolyl)methyl ester
  • N-[(1S)-1-[[(1S,2R)-1-(benzyl)-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazin-1-yl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamic acid (2-isopropylthiazol-4-yl)methyl ester
  • (2S)-N-((1S,2R)-3-{2-[N-(tert-Butyl)carbamoyl]-4-(4-pyridylmethyl)piperazinyl}-2-hydroxy-1-benzylpropyl)-3-methyl-2-({[2-(methylethyl)(1,3-thiazol-4-yl)]methoxy}carbonylamino)butanamide
  • AIDS-071429
  • AIDS071429

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0988 0.0988
Echinococcus granulosus chromobox protein 1 0.0039 0.0334 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0045 0.0398 0.0398
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0318 0.2896
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0859 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0161 0.1764 0.5094
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.0234
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus granulosus peptidase Clp S14 family 0.0068 0.0674 0.0674
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0117 0.0117
Echinococcus multilocularis chromobox protein 1 0.0039 0.0334 0.0334
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Brugia malayi Glycosyl hydrolases family 31 protein 0.0108 0.1142 0.1142
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0152 0.0103
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0386 0.099
Onchocerca volvulus 0.0134 0.1452 0.8232
Brugia malayi CXXC zinc finger family protein 0.0017 0.0064 0.0064
Plasmodium vivax vivapain-2 0.0161 0.1764 1
Giardia lamblia Cathepsin B precursor 0.03 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0386 0.0386
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0149 0.0149
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0089 0.0122
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Echinococcus granulosus beta LACTamase domain containing family member 0.0048 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Echinococcus granulosus cathepsin L cysteine proteinase 0.0161 0.1764 0.1764
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0048 0.0435 0.1073
Loa Loa (eye worm) ctsf protein 0.0161 0.1764 0.1764
Giardia lamblia Cathepsin L-like protease 0.005 0.046 0.117
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.005 0.046 0.1209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.0988 0.0944
Toxoplasma gondii histone lysine methyltransferase SET1 0.0032 0.0246 0.053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0233 0.0233
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0024 0.0152 0.0249
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0318 0.073
Brugia malayi Kringle domain containing protein 0.0035 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0116 0.1235 0.1235
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0117 0.0117
Schistosoma mansoni cpg binding protein 0.0017 0.0075 0.0075
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Trypanosoma cruzi cruzipain precursor, putative 0.0161 0.1764 0.1723
Schistosoma mansoni ap endonuclease 0.0017 0.0069 0.0069
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0104 0.1097 0.1097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.03 0.341 1
Brugia malayi jmjC domain containing protein 0.0079 0.0797 0.0797
Trichomonas vaginalis calpain, putative 0.0024 0.0158 0.031
Onchocerca volvulus 0.0161 0.1764 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Onchocerca volvulus 0.0017 0.0074 0.0417
Trypanosoma cruzi conserved protein 0.0024 0.0158 0.0109
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0386 0.0386
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0117 0.0117
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Trypanosoma brucei cysteine peptidase, putative 0.0024 0.0158 0.0323
Brugia malayi beta-lactamase family protein 0.0048 0.0435 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.013 0.0226
Trichomonas vaginalis maltase-glucoamylase, putative 0.0024 0.0152 0.0292
Plasmodium vivax unspecified product 0.0095 0.0988 0.5426
Brugia malayi jmjC domain containing protein 0.008 0.0808 0.0808
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0069 0.002
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0109
Entamoeba histolytica protein kinase, putative 0.0057 0.054 0.2696
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0095 0.0988 0.0944
Echinococcus multilocularis cathepsin L cysteine protease 0.0161 0.1764 0.1764
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Schistosoma mansoni microtubule-associated protein tau 0.039 0.4466 0.4466
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.1816 1
Onchocerca volvulus 0.0017 0.0064 0.0365
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0386 0.0386
Echinococcus granulosus cathepsin l cysteine peptidase 0.0161 0.1764 0.1764
Echinococcus granulosus cysteine protease 0.0095 0.0988 0.0988
Loa Loa (eye worm) hypothetical protein 0.0045 0.0398 0.0398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Brugia malayi cathepsin L-like cysteine proteinase 0.005 0.046 0.046
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Loa Loa (eye worm) fibroinase 0.0161 0.1764 0.1764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1235 0.3519
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0161 0.1764 0.1764
Brugia malayi Papain family cysteine protease containing protein 0.005 0.046 0.046
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0386 0.0386
Plasmodium falciparum serine repeat antigen 1 0.005 0.046 0.2307
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0859 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Brugia malayi calpain family protein 1 0.0215 0.241 0.241
Plasmodium vivax vivapain-3 0.0095 0.0988 0.5426
Plasmodium falciparum cysteine proteinase falcipain 3 0.0161 0.1764 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0386 0.0386
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0069 0.0626
Giardia lamblia Cathepsin B precursor 0.03 0.341 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0118 0.126 0.126
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0386 0.0386
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0049 0.0049
Brugia malayi Cathepsin L-like precursor 0.0116 0.1235 0.1235
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0069 0.0059
Brugia malayi Papain family cysteine protease containing protein 0.005 0.046 0.046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0435 0.0435
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Brugia malayi cahepsin L-like non-peptiedase homolog 0.005 0.046 0.046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0233 0.0233
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0081 0.0821 0.748
Loa Loa (eye worm) calpain family protein 1 0.0159 0.174 0.174
Leishmania major cysteine peptidase A (CPA) 0.0161 0.1764 0.5101
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0089 0.0122
Schistosoma mansoni cathepsin s 0.0045 0.0398 0.0398
Mycobacterium leprae Probable lipase LipE 0.0048 0.0435 0.1768
Onchocerca volvulus 0.005 0.046 0.2607
Leishmania major calpain protease-like protein 0.0024 0.0158 0.0323
Plasmodium falciparum calpain 0.0024 0.0158 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus multilocularis neutral alpha glucosidase AB 0.0024 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0105 0.1108 0.1108
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Brugia malayi Trypsin family protein 0.01 0.1046 0.1046
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0068 0.0674 0.4744
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.046 0.046
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0038 0.0318 0.0799
Loa Loa (eye worm) heterochromatin protein 1 0.0039 0.0334 0.0334
Plasmodium falciparum serine repeat antigen 2 0.005 0.046 0.2307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Schistosoma mansoni alpha glucosidase 0.0024 0.0152 0.0152
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 1
Echinococcus multilocularis calpain family protein 1, d 0.0159 0.174 0.174
Onchocerca volvulus 0.0048 0.0435 0.2465
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.005 0.046 0.2307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0089 0.0122
Loa Loa (eye worm) hypothetical protein 0.01 0.1051 0.1051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0024 0.015 0.0848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0036 0.0293 0.1321
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.013 0.0226
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0069 0.0069
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Echinococcus multilocularis calpain 0.0081 0.0828 0.0828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0233 0.0233
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.046 0.2307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus multilocularis cathepsin L 0.0095 0.0988 0.0988
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0988 0.0988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Schistosoma mansoni alpha-glucosidase 0.0093 0.0965 0.0965
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0334 0.0834
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0079 0.0797 0.0797
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0225 0.2525 0.2525
Schistosoma mansoni hypothetical protein 0.0105 0.1108 0.1108
Mycobacterium ulcerans lipase LipD 0.0048 0.0435 0.3963
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Schistosoma mansoni chromobox protein 0.0039 0.0334 0.0334
Plasmodium vivax unspecified product 0.0045 0.0398 0.1944
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0104 0.1097 0.6068
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0117 0.0117
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0161 0.1764 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0165 0.1816 0.523
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.01 0.1046 0.1046
Mycobacterium tuberculosis Conserved protein 0.0048 0.0435 0.1073
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215
Trypanosoma brucei Calpain-like protein 2 0.0024 0.0158 0.0323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0386 0.095
Leishmania major hypothetical protein, conserved 0.0021 0.0117 0.0202
Schistosoma mansoni cathepsin F (C01 family) 0.0116 0.1235 0.1235
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0435 0.0388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.046 0.1209
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Onchocerca volvulus 0.0024 0.0149 0.0843
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0435 0.1768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.005 0.046 0.2307
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0386 0.0386
Schistosoma mansoni cpg binding protein 0.0017 0.0075 0.0075
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0069 0.0044
Echinococcus multilocularis cathepsin b 0.0859 1 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Schistosoma mansoni ap endonuclease 0.0017 0.0069 0.0069
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0386 0.0386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0093 0.0961 0.0961
Leishmania major kinesin, putative 0.0057 0.054 0.146
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0386 0.0386
Brugia malayi cathepsin F-like cysteine proteinase 0.0045 0.0398 0.0398
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.6068
Echinococcus multilocularis chromobox protein 1 0.0039 0.0334 0.0334
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.01 0.1051 0.1051
Mycobacterium tuberculosis Probable lipase LipD 0.0048 0.0435 0.1073
Plasmodium vivax calpain, putative 0.0081 0.0828 0.448
Onchocerca volvulus 0.0035 0.0282 0.1597
Loa Loa (eye worm) transcription factor SMAD2 0.008 0.0811 0.0811
Trypanosoma brucei calpain, putative 0.0024 0.0158 0.0323
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0161 0.1764 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Trypanosoma brucei kinesin, putative 0.0057 0.054 0.146
Echinococcus granulosus cathepsin l1 0.0161 0.1764 0.1764
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.01 0.1046 0.1046
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0152 0.0292
Echinococcus multilocularis cathepsin L 0.005 0.046 0.046
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Toxoplasma gondii cathepsin CPC2 0.005 0.046 0.117
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0069 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Echinococcus multilocularis microtubule associated protein 2 0.039 0.4466 0.4466
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0089 0.0041
Echinococcus granulosus geminin 0.0105 0.1108 0.1108
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0282 0.1256
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.005 0.046 0.2307
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0048 0.0435 0.1073
Plasmodium falciparum serine repeat antigen 4 0.005 0.046 0.2307
Toxoplasma gondii preprocathepsin c precursor, putative 0.005 0.046 0.117
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0104 0.1097 0.3078
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0073 0.0073
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0069 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.1019 0.2875
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.046 0.046
Schistosoma mansoni hypothetical protein 0.0035 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Echinococcus granulosus survival motor neuron protein 1 0.0134 0.1445 0.1445
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0021 0.0117 0.0145
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Onchocerca volvulus 0.0027 0.0191 0.1082
Onchocerca volvulus Cathepsin L homolog 0.005 0.046 0.2607
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0081 0.0821 0.2204
Trichomonas vaginalis conserved hypothetical protein 0.005 0.046 0.1209
Loa Loa (eye worm) hypothetical protein 0.0134 0.1445 0.1445
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0024 0.0158 0.0323
Loa Loa (eye worm) jmjC domain-containing protein 0.008 0.0808 0.0808
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.046 0.0413
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.046 0.2307
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Echinococcus multilocularis dnaJ subfamily B 0.0235 0.2643 0.2643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.046 0.1209
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.046 0.2307
Mycobacterium ulcerans hypothetical protein 0.0048 0.0435 0.3963
Trypanosoma cruzi kinesin, putative 0.0057 0.054 0.0493
Loa Loa (eye worm) cathepsin B 0.03 0.341 0.341
Onchocerca volvulus 0.0161 0.1764 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0104 0.1097 0.1097
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Brugia malayi calpain family protein 1 0.0215 0.241 0.241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0859 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0038 0.0318 0.0318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0233 0.0233
Leishmania major hypothetical protein, conserved 0.0024 0.0158 0.0323
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0117 0.0117
Onchocerca volvulus 0.0062 0.0606 0.3434
Onchocerca volvulus 0.0161 0.1764 1
Schistosoma mansoni calpain-7 (C02 family) 0.0085 0.087 0.087
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.005 0.046 0.2307
Mycobacterium ulcerans esterase/lipase LipP 0.0048 0.0435 0.3963
Entamoeba histolytica calpain family cysteine protease, putative 0.0024 0.0158 0.0509
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.03 0.341 0.341
Onchocerca volvulus 0.0161 0.1764 1
Entamoeba histolytica cysteine proteinase 2 0.0095 0.0988 0.5262
Toxoplasma gondii cathepsin B 0.03 0.341 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0073 0.0073
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0017 0.0073 0.0012
Onchocerca volvulus 0.0048 0.0435 0.2465
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0068 0.0674 0.1775
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0282 0.0637
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0215 0.241 0.241
Schistosoma mansoni calpain C (C02 family) 0.0081 0.0828 0.0828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1235 0.3519
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0334 0.0834
Brugia malayi Pre-SET motif family protein 0.0118 0.126 0.126
Plasmodium falciparum serine repeat antigen 3 0.005 0.046 0.2307
Brugia malayi Cytochrome P450 family protein 0.0015 0.0049 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0049 0.0049
Onchocerca volvulus 0.0089 0.0915 0.519
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0161 0.1764 0.5094
Plasmodium falciparum serine repeat antigen 7 0.005 0.046 0.2307
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0016 0.0061 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0152 0.0103
Loa Loa (eye worm) hypothetical protein 0.0063 0.0616 0.0616
Trypanosoma cruzi cruzipain precursor, putative 0.0045 0.0398 0.0351
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Brugia malayi calpain 5 0.0057 0.054 0.054
Trichomonas vaginalis chromobox protein, putative 0.0024 0.015 0.0285
Echinococcus multilocularis cysteine protease 0.0161 0.1764 0.1764
Entamoeba histolytica cysteine proteinase, putative 0.0161 0.1764 0.9697
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0048 0.0435 0.3963
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0022 0.013 0.0736
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.046 0.0413
Brugia malayi Cathepsin L-like cysteine proteinase 0.0116 0.1235 0.1235
Brugia malayi Cytochrome P450 family protein 0.0015 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1046 0.1046
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0988 0.0988
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.046 0.046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0225 0.2525 0.2525
Loa Loa (eye worm) cysteine protease 0.0161 0.1764 0.1764
Schistosoma mansoni hypothetical protein 0.0235 0.2643 0.2643
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0117 0.0117
Onchocerca volvulus 0.01 0.1046 0.5929
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0435 0.0435
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0024 0.0158 0.0109
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.005 0.046 0.2307
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Plasmodium vivax vivapain-2 0.0161 0.1764 1
Brugia malayi hypothetical protein 0.0012 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.008 0.0811 0.0811
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0117 0.0117
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0161 0.1764 0.1764
Echinococcus multilocularis calpain A 0.0225 0.2525 0.2525
Trichomonas vaginalis calpain, putative 0.0024 0.0158 0.031
Schistosoma mansoni cathepsin B (C01 family) 0.005 0.046 0.046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Toxoplasma gondii ABC1 family protein 0.0048 0.0435 0.1095
Mycobacterium tuberculosis Conserved protein 0.0048 0.0435 0.1073
Schistosoma mansoni calpain-2 (C02 family) 0.0024 0.0158 0.0158
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0398 0.0398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.046 0.1209
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0093 0.0961 0.0961
Toxoplasma gondii cathepsin CPL 0.0161 0.1764 0.5072
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Trichomonas vaginalis sucrase-isomaltase, putative 0.0024 0.0152 0.0292
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0104 0.1097 1
Giardia lamblia Cathepsin L-like protease 0.005 0.046 0.117
Onchocerca volvulus 0.0116 0.1235 0.7003
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0117 0.0117
Echinococcus multilocularis geminin 0.0105 0.1108 0.1108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0988 0.2784
Plasmodium falciparum serine repeat antigen 8 0.005 0.046 0.2307
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0079 0.0797 0.0797
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Brugia malayi Cathepsin L-like precursor 0.0116 0.1235 0.1235
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0073 0.0073
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.046 0.046
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0038 0.0318 0.0318
Echinococcus multilocularis cathepsin b 0.0859 1 1
Schistosoma mansoni survival motor neuron protein 0.0027 0.0191 0.0191
Plasmodium vivax JmjC domain containing protein 0.0021 0.0117 0.0285
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0859 1 1
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Onchocerca volvulus 0.0161 0.1764 1
Trichomonas vaginalis hypothetical protein 0.0024 0.0158 0.031
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0161 0.1764 0.1764
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.0808 0.0808
Schistosoma mansoni cathepsin F (C01 family) 0.0161 0.1764 0.1764
Leishmania major calpain family cysteine protease-like protein 0.0024 0.0158 0.0323
Leishmania major hypothetical protein, unknown function 0.0024 0.0158 0.0323
Toxoplasma gondii hypothetical protein 0.0024 0.0158 0.0266
Loa Loa (eye worm) calpain 5 0.0057 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.005 0.046 0.046
Echinococcus granulosus cathepsin b 0.0859 1 1
Echinococcus multilocularis hypothetical protein 0.0081 0.0828 0.0828
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.046 0.117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Brugia malayi Cytochrome P450 family protein 0.0032 0.0248 0.0248
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0282
Brugia malayi fibroinase precursor 0.005 0.046 0.046
Brugia malayi hypothetical protein 0.0019 0.0089 0.0089
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0225 0.2525 0.2525
Brugia malayi Glycosyl hydrolases family 31 protein 0.0024 0.0152 0.0152
Onchocerca volvulus 0.0134 0.1452 0.8232
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.1816 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0117 0.0117
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.046 0.117
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0117 0.0068
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Schistosoma mansoni cathepsin C 0.005 0.046 0.046
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0024 0.0158 0.0266
Echinococcus multilocularis cathepsin L cysteine protease 0.0161 0.1764 0.1764
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0398 0.0398
Schistosoma mansoni calpain-7 (C02 family) 0.0085 0.087 0.087
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Echinococcus granulosus cathepsin L 0.0095 0.0988 0.0988
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0081 0.0828 0.0783
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0386 0.1003
Plasmodium falciparum serine repeat antigen 6 0.005 0.046 0.2307
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Onchocerca volvulus 0.0161 0.1764 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.046 0.2237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0108 0.1142 0.1142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.0988 0.2794
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0048 0.0435 0.0435
Trypanosoma brucei cysteine peptidase C (CPC) 0.03 0.341 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0036 0.0293 0.1321
Brugia malayi cathepsin L-like precursor 0.0116 0.1235 0.1235
Plasmodium vivax SET domain protein, putative 0.0017 0.0073 0.0024
Trypanosoma brucei antigen, putative 0.0081 0.0828 0.2317
Echinococcus multilocularis lysosomal alpha glucosidase 0.0108 0.1142 0.1142
Onchocerca volvulus 0.0048 0.0435 0.2465
Brugia malayi Pre-SET motif family protein 0.0017 0.0073 0.0073
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.0988 0.2794
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.005 0.046 0.1209
Schistosoma mansoni Mername-AA248 (C02 family) 0.0081 0.0828 0.0828
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0386 0.0339
Loa Loa (eye worm) calpain family protein 1 0.0215 0.241 0.241
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0089 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0435 0.0388
Trichomonas vaginalis set domain proteins, putative 0.0134 0.1452 0.4165
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0093 0.0961 0.0961
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0128 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Mycobacterium tuberculosis Conserved protein 0.0048 0.0435 0.1073
Loa Loa (eye worm) hypothetical protein 0.0159 0.174 0.174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0988 0.2784
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0048 0.0435 0.1073
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0027 0.0191 0.0191
Brugia malayi calpain 7 0.0081 0.0828 0.0828
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.005 0.046 0.1209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0859 1 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0859 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.0988 0.0944
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0152 0.0292
Plasmodium falciparum serine repeat antigen 5 0.005 0.046 0.2307
Trypanosoma brucei Calpain-like protein 1.1 0.0024 0.0158 0.0323
Echinococcus multilocularis lysosomal alpha glucosidase 0.0108 0.1142 0.1142
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0035 0.0288 0.0288
Plasmodium falciparum cysteine proteinase falcipain 1 0.0095 0.0988 0.5426
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.005 0.046 0.1209
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0435 0.216
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0225 0.2525 0.2525
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Trypanosoma brucei Calpain-like protein 1.2 0.0024 0.0158 0.0323
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.03 0.341 0.3378
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0215 0.0215
Onchocerca volvulus 0.0161 0.1764 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0386 0.0339
Entamoeba histolytica cysteine protease, putative 0.0161 0.1764 0.9697
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0323
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Loa Loa (eye worm) calpain D 0.0024 0.0158 0.0158
Plasmodium falciparum JmjC domain-containing protein, putative 0.0021 0.0117 0.0285
Loa Loa (eye worm) hypothetical protein 0.0191 0.2122 0.2122
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 1
Echinococcus granulosus calpain 7 C02 family 0.0081 0.0828 0.0828
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Mycobacterium tuberculosis Probable hydrolase 0.0048 0.0435 0.1073
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0161 0.1764 0.1764
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0386 0.099
Echinococcus granulosus lysine specific demethylase 5A 0.008 0.0808 0.0808
Giardia lamblia Hypothetical protein 0.005 0.046 0.117
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0081 0.0828 0.2317
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0988 0.0988
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.029 0.029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0069 0.002
Brugia malayi Protein kinase domain containing protein 0.0035 0.0282 0.0282
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Trypanosoma brucei Calpain-like protein CALP1.3 0.0024 0.0158 0.0323
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Plasmodium vivax vivapain-1 0.0095 0.0988 0.5426
Trichomonas vaginalis chromobox protein, putative 0.0024 0.015 0.0285
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.005 0.046 0.2307
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0128 0.0128
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.005 0.046 0.117
Echinococcus multilocularis calpain 7 (C02 family) 0.0081 0.0828 0.0828
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0386 0.1817
Plasmodium falciparum serine repeat antigen 9 0.005 0.046 0.2307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Echinococcus granulosus calpain A 0.0225 0.2525 0.2525
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0306 0.348 1
Mycobacterium tuberculosis Probable esterase LipL 0.0048 0.0435 0.1073
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.1235 0.1192
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0215 0.0215
Schistosoma mansoni calpain (C02 family) 0.0081 0.0828 0.0828
Trichomonas vaginalis calpain, putative 0.0024 0.0158 0.031
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.0988 0.0944
Entamoeba histolytica cysteine proteinase 1, putative 0.0095 0.0988 0.5262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0233 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Giardia lamblia Hypothetical protein 0.005 0.046 0.117
Brugia malayi hypothetical protein 0.0134 0.1445 0.1445
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Schistosoma mansoni cathepsin S (C01 family) 0.005 0.046 0.046
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.046 0.117
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.005 0.046 0.2307
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Brugia malayi Heterochromatin protein 1 0.0039 0.0334 0.0334
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0021 0.0117 0.0145
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0117 0.0068
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0215 0.241 0.241
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.005 0.046 0.2307
Leishmania major alpha glucosidase II subunit, putative 0.0024 0.0152 0.0306
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0386 0.1003
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0386 0.099
Mycobacterium ulcerans beta-lactamase 0.0048 0.0435 0.3963
Schistosoma mansoni alpha-glucosidase 0.0093 0.0965 0.0965
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0117 0.0117
Trypanosoma brucei hypothetical protein 0.0024 0.0158 0.0323
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0049 0.0447
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1046 0.1046
Toxoplasma gondii cathepsin CPC1 0.005 0.046 0.117
Echinococcus multilocularis peptidase Clp (S14 family) 0.0068 0.0674 0.0674
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0069 0.0044
Echinococcus granulosus calpain 0.0081 0.0828 0.0828
Trypanosoma brucei glucosidase, putative 0.0024 0.0152 0.0306
Loa Loa (eye worm) beta-lactamase 0.0048 0.0435 0.0435
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.046 0.2307
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0074
Echinococcus multilocularis calpain 5 0.0081 0.0828 0.0828
Treponema pallidum fructose-bisphosphate aldolase 0.0165 0.1816 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0093 0.0961 0.0961
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0282 0.0282
Brugia malayi chromobox protein homolog 3 0.0022 0.013 0.013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Brugia malayi beta-lactamase family protein 0.0048 0.0435 0.0435
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0117 0.0117
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Leishmania major hypothetical protein, conserved 0.0019 0.0089 0.012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0048 0.0435 0.0435
Brugia malayi latrophilin 2 splice variant baaae 0.0063 0.0616 0.0616
Trichomonas vaginalis esterase, putative 0.0048 0.0435 0.1135
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0117 0.0117
Echinococcus granulosus calpain 5 0.0081 0.0828 0.0828
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0104 0.1097 0.1097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0104 0.1097 0.3078
Schistosoma mansoni chromobox protein 0.0039 0.0334 0.0334
Brugia malayi cathepsin L precursor 0.005 0.046 0.046
Giardia lamblia Encystation-specific protease 0.005 0.046 0.117
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0048 0.0435 0.0435
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0089 0.0041
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0038 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0116 0.1235 0.1235
Trypanosoma cruzi kinesin, putative 0.0057 0.054 0.0493
Echinococcus multilocularis survival motor neuron protein 1 0.0134 0.1445 0.1445
Entamoeba histolytica cysteine proteinase, putative 0.0116 0.1235 0.6673
Echinococcus multilocularis cysteine protease 0.0161 0.1764 0.1764
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Entamoeba histolytica hypothetical protein 0.005 0.046 0.2237
Trichomonas vaginalis conserved hypothetical protein 0.005 0.046 0.1209
Echinococcus multilocularis GPCR, family 2 0.0029 0.0215 0.0215
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0282 0.0282
Brugia malayi Papain family cysteine protease containing protein 0.005 0.046 0.046
Echinococcus granulosus chromobox protein 1 0.0039 0.0334 0.0334
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Echinococcus granulosus phd:f box containing protein 0.0021 0.0117 0.0117
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.005 0.046 0.2307
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0988 0.0988
Entamoeba histolytica calpain large subunit domain III containing protein 0.0057 0.054 0.2696
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.03 0.341 1
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Echinococcus granulosus GPCR family 2 0.0029 0.0215 0.0215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Schistosoma mansoni cathepsin F (C01 family) 0.0161 0.1764 0.1764
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Echinococcus granulosus cathepsin L cysteine protease 0.0095 0.0988 0.0988
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus granulosus microtubule associated protein 2 0.039 0.4466 0.4466
Plasmodium vivax unspecified product 0.005 0.046 0.2307
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.005 0.046 0.046
Onchocerca volvulus Cathepsin L homolog 0.0161 0.1764 1
Loa Loa (eye worm) MH2 domain-containing protein 0.008 0.0811 0.0811
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0233 0.0233
Echinococcus granulosus dnaJ subfamily B 0.0235 0.2643 0.2643
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0017 0.0073 0.0073
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0117 0.0117
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.005 0.046 0.2307
Echinococcus granulosus cathepsin b 0.0859 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.005 0.046 0.2307
Toxoplasma gondii hypothetical protein 0.0036 0.0293 0.067
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Loa Loa (eye worm) hypothetical protein 0.0104 0.1097 0.1097
Entamoeba histolytica cysteine proteinase, putative 0.0161 0.1764 0.9697
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0073 0.0073
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0435 0.1135
Brugia malayi calpain D 0.0024 0.0158 0.0158
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Loa Loa (eye worm) hypothetical protein 0.0116 0.1235 0.1235
Echinococcus granulosus cpg binding protein 0.0017 0.0075 0.0075
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.046 0.2237
Schistosoma mansoni hypothetical protein 0.0027 0.0191 0.0191
Trypanosoma brucei calpain, putative 0.0024 0.0158 0.0323
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0117 0.0117
Mycobacterium tuberculosis Probable lipase LipE 0.0048 0.0435 0.1073
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0398 0.0351
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.0808 0.0808
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Loa Loa (eye worm) hypothetical protein 0.0161 0.1764 0.1764
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0435 0.1135
Loa Loa (eye worm) hypothetical protein 0.0022 0.013 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Onchocerca volvulus Cathepsin F homolog 0.0161 0.1764 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1452 0.1452
Schistosoma mansoni cpg binding protein 0.0017 0.0064 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0435 0.1148
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.5884
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0045 0.0398 0.0398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0318 0.2896
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0435 0.1135
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Brugia malayi Papain family cysteine protease containing protein 0.0161 0.1764 0.1764
Echinococcus granulosus calpain A 0.0081 0.0828 0.0828
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0797 0.0797
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.046 0.046
Leishmania major hypothetical protein, conserved 0.0048 0.0435 0.1148
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0069 0.0069
Brugia malayi Cathepsin L-like precursor 0.0045 0.0398 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Onchocerca volvulus Cathepsin L homolog 0.0161 0.1764 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0248 0.0248
Brugia malayi beta-lactamase 0.0048 0.0435 0.0435
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.0064 0.0064
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0081 0.0821 0.6564
Echinococcus granulosus cathepsin L 0.005 0.046 0.046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0215 0.0215
Trypanosoma cruzi cysteine protease, putative 0.0095 0.0988 0.0944
Loa Loa (eye worm) hypothetical protein 0.0029 0.0215 0.0215
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.046 0.046
Echinococcus multilocularis cpg binding protein 0.0017 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0024 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0435 0.1135
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0068 0.0674 0.1775
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0215 0.0215
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0117 0.0202
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.005 0.046 0.046
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0024 0.0152 0.0477
Leishmania major hypothetical protein, conserved 0.0035 0.0282 0.0692
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0089 0.0062
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0024 0.0152 0.0477
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Echinococcus granulosus lysosomal alpha glucosidase 0.0108 0.1142 0.1142
Echinococcus granulosus neutral alpha glucosidase AB 0.0024 0.0152 0.0152
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0435 0.1135
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0038 0.0318 0.0318
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215
Loa Loa (eye worm) calpain 0.0081 0.0828 0.0828
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0073 0.0073
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.5
Brugia malayi calpain 5 0.0024 0.0158 0.0158
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0215 0.0215
Brugia malayi Probable ClpP-like protease 0.0104 0.1097 0.1097
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0024 0.0152 0.0152
Echinococcus granulosus cathepsin l1 0.0116 0.1235 0.1235
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0282 0.1256
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0036 0.0293 0.1281
Giardia lamblia Cathepsin B precursor 0.03 0.341 1
Schistosoma mansoni hypothetical protein 0.0063 0.0616 0.0616
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0158 0.031

Activities

Activity type Activity value Assay description Source Reference
CCIC50 (functional) = 56 uM Cytotoxicity against MT-4 cells was determined by using cytopathic effect assay ChEMBL. 9934466
CCIC50 (functional) = 56 uM Cytotoxicity against MT-4 cells was determined by using cytopathic effect assay ChEMBL. 9934466
EC50 (functional) = 0.017 uM Anti-HIV activity was determined in MT-4 cells in the presence of 0% human serum using cytopathic effect assay ChEMBL. 9934466
EC50 (functional) = 0.076 uM Anti-HIV activity was determined in MT-4 cells in the presence of 50% human serum using cytopathic effect assay ChEMBL. 9934466
Inhibition (binding) = 73 % Inhibition of HIV protease at 0.5 nM ChEMBL. 9934466
Inhibition (binding) = 73 % Inhibition of HIV protease at 0.5 nM ChEMBL. 9934466

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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