Detailed information for compound 223850

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 256.26 | Formula: C13H12N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)N/N=C\c1ccc(cc1)Oc1ccncc1
  • InChi: 1S/C13H12N4O2/c14-13(18)17-16-9-10-1-3-11(4-2-10)19-12-5-7-15-8-6-12/h1-9H,(H3,14,17,18)/b16-9-
  • InChiKey: MICRFRUBLYAXDL-SXGWCWSVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0365 0.2316 1
Echinococcus granulosus transcription factor Dp 1 0.0031 0.0082 0.0165
Mycobacterium tuberculosis Probable oxidoreductase 0.0078 0.0398 0.0365
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0024 0.0055
Echinococcus multilocularis GPCR, family 2 0.0035 0.0109 0.0164
Mycobacterium tuberculosis Probable dehydrogenase 0.0071 0.0345 0.0313
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.011 0.0611 0.1399
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Echinococcus multilocularis histone acetyltransferase MYST2 0.0034 0.0101 0.0151
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0032 0.0084 0.017
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0054 0.0234 0.0985
Echinococcus granulosus integrin alpha ps 0.0146 0.0854 0.1726
Mycobacterium tuberculosis Conserved hypothetical protein 0.013 0.0744 0.0713
Echinococcus granulosus dna polymerase kappa 0.0032 0.0084 0.017
Giardia lamblia Tenascin-like 0.0033 0.0093 0.0277
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.025
Echinococcus granulosus adam 0.0033 0.0093 0.0189
Mycobacterium ulcerans hypothetical protein 0.0034 0.0101 0.0254
Giardia lamblia High cysteine protein 0.0033 0.0093 0.0277
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0107 0.0245
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0122 0.0171
Brugia malayi hypothetical protein 0.0035 0.0107 0.0149
Leishmania major DNA polymerase eta, putative 0.0052 0.0223 0.0939
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.0007 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0101 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0018 0.005
Loa Loa (eye worm) hypothetical protein 0.0116 0.0647 0.0953
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0106 0.0318
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0024 0.0055
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0034 0.0101 0.0067
Loa Loa (eye worm) hypothetical protein 0.007 0.0343 0.0501
Mycobacterium ulcerans hydrolase 0.0057 0.0251 0.0916
Echinococcus granulosus SAM and MBT domain containing protein 0.003 0.0073 0.0147
Schistosoma mansoni integrin alpha-ps 0.0076 0.0384 0.0878
Loa Loa (eye worm) hypothetical protein 0.0076 0.0384 0.0561
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0365 0.2316 0.4679
Mycobacterium ulcerans DNA polymerase IV 0.0032 0.0084 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0107 0.0321
Leishmania major DNA polymerase eta, putative 0.0031 0.0078 0.0307
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0034 0.0101 0.0057
Entamoeba histolytica deoxycytidyl transferase, putative 0.0032 0.0084 0.0247
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0032 0.0084 0.0192
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.003 0.0073 0.0167
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0054 0.0234 0.0473
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0032 0.0084 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0107 0.0321
Brugia malayi RNA, U transporter 1 0.0077 0.0391 0.0572
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0109 0.0153
Onchocerca volvulus 0.0059 0.0267 0.3511
Echinococcus multilocularis SAM and MBT domain containing protein 0.003 0.0073 0.0109
Mycobacterium tuberculosis Conserved protein 0.0035 0.0107 0.0074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.0123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0109 0.0164
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0034 0.0101 0.0254
Trypanosoma brucei unspecified product 0.0022 0.0018 0.005
Plasmodium vivax importin-beta 2, putative 0.0027 0.0055 0.0209
Brugia malayi mbt repeat family protein 0.003 0.0073 0.0099
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0109 0.0221
Echinococcus granulosus Msx-like 0.035 0.2215 0.4476
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0107 0.0321
Schistosoma mansoni alpha glucosidase 0.0023 0.0024 0.0054
Loa Loa (eye worm) mbt repeat family protein 0.003 0.0073 0.0099
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0106 0.043
Echinococcus multilocularis geminin 0.0167 0.0995 0.149
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0149
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0122 0.0278
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Brugia malayi EGF-like domain containing protein 0.0033 0.0093 0.0129
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0365 0.2316 0.347
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0018 0.005
Loa Loa (eye worm) hypothetical protein 0.0127 0.0724 0.1068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0263
Brugia malayi hypothetical protein 0.0116 0.0647 0.0953
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0109 0.0602 0.1378
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0073 0.0098
Mycobacterium ulcerans hypothetical protein 0.0035 0.0107 0.0282
Echinococcus multilocularis homeobox 0.035 0.2215 0.3319
Mycobacterium leprae POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI 0.0365 0.2316 0.657
Loa Loa (eye worm) matrixin family protein 0.0112 0.0625 0.092
Brugia malayi EGF-like domain containing protein 0.0033 0.0093 0.0129
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0238 0.1464 0.1436
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.008 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.0087 0.0458 0.1827
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0107 0.0074
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0202 0.0291
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0034 0.0101 0.0254
Echinococcus granulosus integrin alpha 3 0.025 0.1551 0.3134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0149
Plasmodium vivax glutathione reductase, putative 0.0031 0.008 0.0316
Echinococcus granulosus jumonji domain containing protein 0.0033 0.0095 0.0191
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0087 0.0458 0.1956
Trichomonas vaginalis esterase, putative 0.0035 0.0107 0.0321
Schistosoma mansoni transcription factor 0.035 0.2215 0.5069
Echinococcus multilocularis transcription factor Dp 1 0.0031 0.0082 0.0123
Leishmania major 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative 0.0365 0.2316 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0109 0.0153
Echinococcus multilocularis Niemann Pick C1 protein 0.0088 0.0461 0.0691
Toxoplasma gondii PHD-finger domain-containing protein 0.0024 0.0032 0.0111
Mycobacterium ulcerans recombinase A 0.0092 0.0488 0.1957
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0078 0.0307
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0023 0.0024 0.0055
Plasmodium falciparum thioredoxin reductase 0.0031 0.008 0.0316
Loa Loa (eye worm) hypothetical protein 0.0256 0.1592 0.2359
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0437 0.2803 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0106 0.0277
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0106 0.0318
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0078 0.0396 0.0593
Echinococcus multilocularis expressed protein 0.0027 0.0055 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0107 0.0321
Schistosoma mansoni hypothetical protein 0.0185 0.1112 0.2544
Brugia malayi Inositol-1 0.0035 0.0106 0.0148
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0023 0.0024 0.0055
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0365 0.2316 0.4679
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0034 0.0101 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0107 0.0435
Giardia lamblia Tenascin precursor 0.0033 0.0093 0.0277
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0078 0.0396 0.0799
Onchocerca volvulus 0.0066 0.0314 0.4211
Onchocerca volvulus 0.0035 0.0107 0.1121
Toxoplasma gondii histone lysine methyltransferase SET1 0.0034 0.0101 0.0409
Echinococcus multilocularis polycomb protein SCMH1 0.003 0.0073 0.0109
Trypanosoma brucei DNA polymerase eta, putative 0.0052 0.0223 0.0939
Schistosoma mansoni alpha-glucosidase 0.0088 0.0459 0.1051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0054
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.002 0.0059
Brugia malayi hypothetical protein 0.0124 0.07 0.1032
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0054 0.0234 0.0985
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0486 0.3131 1
Echinococcus granulosus GPCR family 2 0.0035 0.0109 0.0221
Schistosoma mansoni aldehyde dehydrogenase 0.0087 0.0458 0.1049
Mycobacterium ulcerans beta-lactamase 0.0035 0.0107 0.0282
Plasmodium falciparum glutathione reductase 0.0031 0.008 0.0316
Brugia malayi Glycosyl hydrolases family 31 protein 0.0023 0.0024 0.0025
Echinococcus multilocularis sterol regulatory element binding protein 0.0026 0.0049 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.002 0.0044
Echinococcus multilocularis protein jagged 2 0.0033 0.0093 0.014
Schistosoma mansoni inositol monophosphatase 0.0035 0.0106 0.0243
Onchocerca volvulus Matrilysin homolog 0.0046 0.0184 0.2265
Leishmania major 4-coumarate:coa ligase-like protein 0.0034 0.0101 0.0408
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0031 0.008 0.0046
Schistosoma mansoni integrin beta subunit 0.0602 0.3908 0.8943
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0101 0.014
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0101 0.014
Echinococcus granulosus lysosomal alpha glucosidase 0.0102 0.0554 0.112
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0032 0.0111
Schistosoma mansoni terminal deoxycytidyl transferase 0.0032 0.0084 0.0192
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.003 0.0073 0.0609
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0035 0.0105 0.0426
Echinococcus multilocularis protein dispatched 1 0.003 0.0074 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.0032 0.0084 0.0335
Onchocerca volvulus 0.003 0.0073 0.0609
Schistosoma mansoni sex comb on midleg homolog 0.003 0.0073 0.0167
Giardia lamblia Neurogenic locus Notch protein precursor 0.0033 0.0093 0.0277
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0054 0.0234 0.0536
Echinococcus multilocularis integrin alpha ps 0.0146 0.0854 0.128
Schistosoma mansoni hypothetical protein 0.0256 0.1591 0.3641
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0599 0.3886 0.8891
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0032 0.0084 0.0335
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.025
Echinococcus multilocularis importin subunit beta 1 0.0027 0.0055 0.0082
Toxoplasma gondii aldehyde dehydrogenase 0.0087 0.0458 0.1956
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0027 0.0051 0.0193
Mycobacterium tuberculosis Conserved protein 0.0035 0.0107 0.0074
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0365 0.2316 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0054 0.0234 0.0339
Loa Loa (eye worm) integrin beta-2 0.1022 0.6726 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.029 0.1819 0.2698
Mycobacterium ulcerans lipase LipD 0.0035 0.0107 0.0282
Echinococcus multilocularis Phospholipid glycerol acyltransferase 0.0365 0.2316 0.347
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0107 0.0282
Brugia malayi Acyltransferase family protein 0.0365 0.2316 0.3437
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0156 0.0647
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0035 0.0105 0.0426
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0263
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0107 0.0435
Echinococcus multilocularis dna polymerase kappa 0.0032 0.0084 0.0126
Brugia malayi Kelch motif family protein 0.0155 0.0914 0.135
Echinococcus multilocularis integrin alpha ps 0.0146 0.0854 0.128
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Brugia malayi Bromodomain containing protein 0.0024 0.0032 0.0038
Onchocerca volvulus 0.003 0.0074 0.063
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0051 0.0193
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0023 0.0024 0.0055
Schistosoma mansoni hypothetical protein 0.003 0.0074 0.017
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0023 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0076 0.0384 0.0561
Echinococcus granulosus snurportin 1 0.029 0.1819 0.3676
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0055 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0018 0.005
Echinococcus multilocularis lysosomal alpha glucosidase 0.0102 0.0554 0.0831
Trichomonas vaginalis DNA polymerase eta, putative 0.0032 0.0084 0.0247
Plasmodium vivax acyl-CoA synthetase, putative 0.0025 0.0043 0.0158
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0027 0.0051 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0107 0.0245
Chlamydia trachomatis recombinase RecA 0.0092 0.0488 0.1957
Echinococcus granulosus muscleblind protein 0.0127 0.0724 0.1463
Loa Loa (eye worm) hypothetical protein 0.0116 0.0647 0.0953
Entamoeba histolytica acyl-CoA synthetase, putative 0.0034 0.0101 0.0301
Echinococcus multilocularis expressed conserved protein 0.0058 0.0259 0.0389
Brugia malayi Integrin alpha pat-2 precursor 0.0327 0.2062 0.3059
Mycobacterium tuberculosis Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri 0.035 0.2215 0.2189
Brugia malayi PHD-finger family protein 0.0024 0.0032 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0107 0.0074
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0071 0.0345 0.0775
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.437 0.6548
Entamoeba histolytica acyl-coA synthetase, putative 0.0034 0.0101 0.0301
Brugia malayi beta-lactamase family protein 0.0035 0.0107 0.0149
Echinococcus multilocularis neutral alpha glucosidase AB 0.0023 0.0024 0.0036
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0032 0.0038
Toxoplasma gondii hypothetical protein 0.004 0.0139 0.0575
Brugia malayi hypothetical protein 0.0148 0.0862 0.1273
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0024 0.0055
Giardia lamblia DINP protein human, muc B family 0.0032 0.0084 0.0247
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0054 0.0234 0.0339
Echinococcus granulosus expressed conserved protein 0.0058 0.0259 0.0524
Loa Loa (eye worm) beta-lactamase 0.0035 0.0107 0.0149
Echinococcus granulosus importin subunit beta 1 0.0027 0.0055 0.0111
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0247 0.1527 0.6585
Mycobacterium ulcerans DNA polymerase IV 0.0032 0.0084 0.018
Trichomonas vaginalis rotamase, putative 0.0027 0.0051 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Brugia malayi Thioredoxin reductase 0.0031 0.008 0.0109
Onchocerca volvulus 0.0033 0.0093 0.0915
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0129
Mycobacterium leprae Probable lipase LipE 0.0035 0.0107 0.0075
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0288 0.0659
Echinococcus multilocularis Niemann Pick C1 protein 0.0061 0.0284 0.0426
Giardia lamblia Neurogenic locus notch-like protein 0.0033 0.0093 0.0277
Brugia malayi EGF-like domain containing protein 0.0033 0.0093 0.0129
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0027 0.0055 0.0073
Leishmania major trypanothione reductase 0.0031 0.008 0.0316
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0054 0.0234 0.0351
Schistosoma mansoni integrin alpha-ps 0.0146 0.0854 0.1954
Schistosoma mansoni hypothetical protein 0.007 0.0343 0.0785
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0024 0.0032 0.0074
Giardia lamblia Fructose-bisphosphate aldolase 0.0486 0.3131 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0071 0.0345 0.0313
Echinococcus granulosus polycomb protein SCMH1 0.003 0.0073 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0101 0.0254
Loa Loa (eye worm) hypothetical protein 0.0061 0.0284 0.0413
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0078 0.0307
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0107 0.0321
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.0223 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0122 0.0278
Brugia malayi beta-lactamase family protein 0.0035 0.0107 0.0149
Echinococcus granulosus survival motor neuron protein 1 0.0148 0.0862 0.1742
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0107 0.016
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0073 0.0166
Schistosoma mansoni alpha-glucosidase 0.0088 0.0459 0.1051
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0247 0.1527 0.6585
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0122 0.0278
Schistosoma mansoni survival motor neuron protein 0.003 0.0074 0.017
Trichomonas vaginalis rotamase, putative 0.0027 0.0055 0.0156
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.003 0.0074 0.0101
Giardia lamblia PHD finger protein 15 0.0024 0.0032 0.0082
Echinococcus granulosus integrin alpha ps 0.007 0.0343 0.0693
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0098
Schistosoma mansoni importin beta-1 0.0027 0.0055 0.0125
Loa Loa (eye worm) inositol-1 0.0035 0.0106 0.0148
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0092 0.0488 0.1195
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0031 0.0082 0.0048
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0107 0.0074
Loa Loa (eye worm) hypothetical protein 0.0365 0.2316 0.3437
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0034 0.0101 0.0203
Echinococcus granulosus PHD finger protein rhinoceros 0.0024 0.0032 0.0065
Loa Loa (eye worm) hypothetical protein 0.0155 0.0914 0.135
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0109 0.0164
Echinococcus multilocularis muscleblind protein 0.0127 0.0724 0.1085
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0057 0.0251 0.0218
Toxoplasma gondii ABC1 family protein 0.0035 0.0107 0.0435
Trypanosoma cruzi DNA repair protein, putative 0.0028 0.0062 0.0239
Entamoeba histolytica acyl-CoA synthetase, putative 0.0034 0.0101 0.0301
Echinococcus multilocularis protein patched 0.0026 0.0049 0.0074
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0054 0.0234 0.0985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0122 0.0246
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0055 0.0209
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0092 0.0488 0.1416
Entamoeba histolytica hypothetical protein 0.0035 0.0107 0.0321
Echinococcus multilocularis muscleblind protein 1 0.0127 0.0724 0.1085
Echinococcus granulosus Protein patched homolog 1 0.0026 0.0049 0.01
Entamoeba histolytica hypothetical protein 0.0035 0.0107 0.0321
Brugia malayi Glycosyl hydrolases family 31 protein 0.0102 0.0554 0.0815
Schistosoma mansoni DNA polymerase eta 0.0052 0.0223 0.0511
Trypanosoma brucei glucosidase, putative 0.0023 0.0024 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.0621 0.0914
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0033 0.0093 0.0277
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0057 0.0251 0.0364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0038
Echinococcus multilocularis lysosomal alpha glucosidase 0.0102 0.0554 0.0831
Wolbachia endosymbiont of Brugia malayi 1-acyl-sn-glycerol-3-phosphate acyltransferase 0.0365 0.2316 0.8194
Brugia malayi jmjC domain containing protein 0.0078 0.0396 0.0579
Loa Loa (eye worm) matrix metalloproteinase 0.0046 0.0184 0.0263
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0101 0.0254
Trypanosoma brucei DNA polymerase IV, putative 0.0032 0.0084 0.0335
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0025 0.0043 0.0009
Echinococcus granulosus fibrillin 2 0.0033 0.0093 0.0189
Brugia malayi CHE-14 protein 0.0026 0.0049 0.0063
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0071 0.0345 0.0313
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0078 0.0398 0.0931
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0107 0.0245
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0063
Echinococcus multilocularis snurportin 1 0.029 0.1819 0.2726
Loa Loa (eye worm) hypothetical protein 0.035 0.2215 0.3287
Mycobacterium ulcerans aldehyde dehydrogenase 0.0087 0.0458 0.1827
Toxoplasma gondii thioredoxin reductase 0.0031 0.008 0.0316
Plasmodium falciparum phd finger protein, putative 0.0024 0.0032 0.0111
Schistosoma mansoni hypothetical protein 0.0076 0.0384 0.0879
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.002 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0055 0.0156
Echinococcus granulosus Niemann Pick C1 protein 0.0088 0.0461 0.0932
Loa Loa (eye worm) integrin alpha pat-2 0.0504 0.3248 0.4824
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0098
Echinococcus multilocularis PHD finger protein rhinoceros 0.0024 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.018 0.108 0.1598
Trypanosoma brucei unspecified product 0.0032 0.0084 0.0335
Echinococcus granulosus integrin beta 2 0.0757 0.4949 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0107 0.0074
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0073 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0049 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0128 0.0294
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0129
Echinococcus granulosus thioredoxin glutathione reductase 0.0031 0.0082 0.0167
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0169 0.1004 0.2028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0071 0.0345 0.0313
Brugia malayi Muscleblind-like protein 0.0127 0.0724 0.1068
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0107 0.0074
Echinococcus multilocularis peregrin 0.0024 0.0032 0.0048
Brugia malayi beta-lactamase 0.0035 0.0107 0.0149
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0117 0.0656 0.281
Onchocerca volvulus Matrilysin homolog 0.0103 0.0562 0.7936
Schistosoma mansoni inositol monophosphatase 0.0035 0.0106 0.0243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0122 0.0182
Schistosoma mansoni polycystin 1-related 0.0038 0.013 0.0297
Brugia malayi Niemann-Pick C1 protein precursor 0.0061 0.0284 0.0413
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0024 0.0055
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0078 0.0398 0.0365
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0107 0.0282
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0062 0.0291 0.0666
Onchocerca volvulus Huntingtin homolog 0.0116 0.0647 0.9205
Onchocerca volvulus 0.0035 0.0107 0.1121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0109 0.0221
Schistosoma mansoni hypothetical protein 0.0167 0.0995 0.2276
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0087 0.0458 0.0687
Trypanosoma cruzi DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Echinococcus multilocularis integrin alpha ps 0.007 0.0343 0.0514
Schistosoma mansoni hypothetical protein 0.0167 0.0995 0.2276
Mycobacterium ulcerans 1-acylglycerol-3-phosphate O-acyltransferase 0.0365 0.2316 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0621 0.0914
Loa Loa (eye worm) MBCTL1 0.0034 0.0101 0.014
Mycobacterium leprae PROBABLE HYDROLASE 0.0057 0.0251 0.0499
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.025
Loa Loa (eye worm) hypothetical protein 0.0247 0.1529 0.2265
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0107 0.0216
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0169 0.1004 0.1504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0034 0.0101 0.0408
Mycobacterium leprae Conserved hypothetical protein 0.0539 0.3482 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0149
Schistosoma mansoni myelin transcription factor 1 myt1 0.0034 0.0101 0.023
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0238 0.1464 0.4067
Loa Loa (eye worm) hypothetical protein 0.0052 0.0223 0.0323
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0129
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0078 0.0398 0.0365
Brugia malayi jmjC domain containing protein 0.003 0.0073 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0155 0.0914 0.135
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0046 0.0184 0.042
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0087 0.0458 0.0926
Toxoplasma gondii peptidylprolyl isomerase 0.0027 0.0051 0.0193
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0054 0.0234 0.0985
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.025
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0099
Entamoeba histolytica hypothetical protein 0.0022 0.002 0.0044
Leishmania major DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Trypanosoma cruzi 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0365 0.2316 1
Echinococcus multilocularis adam 0.0033 0.0093 0.014
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0035 0.0106 0.0318
Trichomonas vaginalis importin beta-1, putative 0.0022 0.002 0.0044
Toxoplasma gondii acyltransferase domain-containing protein 0.0365 0.2316 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0087 0.0458 0.1827
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0084 0.005
Plasmodium falciparum importin beta, putative 0.0027 0.0055 0.0209
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0107 0.016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0109 0.0153
Leishmania major mitochondrial DNA polymerase beta 0.0247 0.1527 0.6585
Treponema pallidum lysophosphatidic acid acyltransferase 0.0365 0.2316 0.6914
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0486 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0072
Echinococcus granulosus dna polymerase eta 0.0052 0.0223 0.0452
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0026 0.0049 0.0063
Toxoplasma gondii PHD-finger domain-containing protein 0.0024 0.0032 0.0111
Schistosoma mansoni ran 0.002 0.0007 0.0015
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0098
Trypanosoma brucei trypanothione reductase 0.0031 0.008 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0107 0.0435
Leishmania major 4-coumarate:coa ligase-like protein 0.0034 0.0101 0.0408
Mycobacterium ulcerans acyl-CoA synthetase 0.0034 0.0101 0.0254
Schistosoma mansoni ran 0.002 0.0007 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0071 0.0345 0.0313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Brugia malayi glutathione reductase 0.0031 0.008 0.0109
Echinococcus multilocularis integrin alpha 3 0.025 0.1551 0.2324
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0149
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0121 0.0683 0.138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0106 0.043
Mycobacterium ulcerans hypothetical protein 0.013 0.0744 0.3085
Echinococcus multilocularis fibrillin 2 0.0033 0.0093 0.014
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.014
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0055 0.0209
Schistosoma mansoni hypothetical protein 0.029 0.1819 0.4163
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Schistosoma mansoni integrin alpha 0.0327 0.2062 0.4719
Onchocerca volvulus Huntingtin homolog 0.0116 0.0647 0.9205
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0035 0.0105 0.0426
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0101 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.0084 0.0115
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0365 0.2316 0.347
Brugia malayi Importin beta-1 subunit 0.0027 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0263
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1015 0.6674 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0031 0.0082 0.0124
Schistosoma mansoni sex comb on midleg homolog 0.003 0.0073 0.0167
Echinococcus multilocularis integrin beta 2 0.0757 0.4949 0.7416
Leishmania major importin beta-1 subunit, putative 0.0022 0.002 0.0059
Onchocerca volvulus Matrix metalloproteinase homolog 0.0103 0.0562 0.7936
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0054
Echinococcus granulosus dnaJ subfamily B 0.0256 0.1591 0.3215
Giardia lamblia hypothetical protein 0.0033 0.0093 0.0277
Echinococcus granulosus fibrillin 1 0.0033 0.0093 0.0189
Echinococcus multilocularis jumonji domain containing protein 0.0033 0.0095 0.0142
Brugia malayi Matrixin family protein 0.0046 0.0184 0.0263
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0027 0.0051 0.0193
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0027 0.0051 0.0142
Toxoplasma gondii acyltransferase domain-containing protein 0.0365 0.2316 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0032 0.0084 0.0247
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0107 0.0075
Mycobacterium ulcerans bifunctional transmembrane phospholipid biosynthesis enzyme PlsC 0.0365 0.2316 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0023 0.0024 0.0025
Brugia malayi hypothetical protein 0.0155 0.0914 0.135
Echinococcus multilocularis survival motor neuron protein 1 0.0148 0.0862 0.1292
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0121 0.0683 0.1024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.0621 0.0914
Onchocerca volvulus 0.0034 0.0101 0.1027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0101 0.0067
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0107 0.0435
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0107 0.0149
Giardia lamblia Tenascin-37 0.0033 0.0093 0.0277
Toxoplasma gondii hypothetical protein 0.0033 0.0093 0.0375
Trypanosoma brucei unspecified product 0.0022 0.0018 0.005
Giardia lamblia Tenascin-X 0.0033 0.0093 0.0277
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0054 0.0234 0.0728
Echinococcus granulosus peregrin 0.0024 0.0032 0.0065
Brugia malayi Matrixin family protein 0.0046 0.0184 0.0263
Schistosoma mansoni hypothetical protein 0.0025 0.0043 0.0098
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0107 0.0074
Schistosoma mansoni patched 1 0.0026 0.0049 0.0113
Leishmania major alpha glucosidase II subunit, putative 0.0023 0.0024 0.0074
Plasmodium falciparum acyl-CoA synthetase 0.0025 0.0043 0.0158
Trichomonas vaginalis sucrase-isomaltase, putative 0.0023 0.0024 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0024 0.0074
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0107 0.0149
Mycobacterium tuberculosis Conserved protein 0.0035 0.0107 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0034 0.0101 0.0057
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.014
Brugia malayi Matrixin family protein 0.0112 0.0625 0.092
Echinococcus granulosus neutral alpha glucosidase AB 0.0023 0.0024 0.0048
Loa Loa (eye worm) hypothetical protein 0.0127 0.0724 0.1068
Echinococcus granulosus sterol regulatory element binding protein 0.0026 0.0049 0.01
Treponema pallidum fructose-bisphosphate aldolase 0.0486 0.3131 1
Loa Loa (eye worm) glutathione reductase 0.0031 0.008 0.0109
Mycobacterium tuberculosis 1-acylglycerol-3-phosphate O-acyltransferase 0.0365 0.2316 0.229
Entamoeba histolytica hypothetical protein 0.0035 0.0107 0.0321
Loa Loa (eye worm) hypothetical protein 0.0124 0.07 0.1032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Entamoeba histolytica hypothetical protein 0.0035 0.0107 0.0321
Echinococcus multilocularis lysine specific demethylase 5A 0.0029 0.0066 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.0032 0.0084 0.0335
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0054
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0106 0.0159
Brugia malayi Matrixin family protein 0.0046 0.0184 0.0263
Schistosoma mansoni hypothetical protein 0.0066 0.0314 0.0718
Echinococcus granulosus histone acetyltransferase MYST2 0.0034 0.0101 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Echinococcus multilocularis fibrillin 1 0.004 0.0143 0.0214
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0032 0.0084 0.005
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0247 0.1529 0.2265
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0084 0.0335
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0028 0.0062 0.0239
Trypanosoma brucei 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0365 0.2316 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.014
Brugia malayi Integrin beta pat-3 precursor 0.1022 0.6726 1
Onchocerca volvulus 0.0035 0.0107 0.1121
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0106 0.043
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0106 0.0214
Onchocerca volvulus 0.0124 0.07 1
Plasmodium falciparum 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0365 0.2316 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0102 0.0554 0.0815
Trichomonas vaginalis hypothetical protein 0.0033 0.0093 0.0277
Echinococcus granulosus Phospholipid glycerol acyltransferase 0.0365 0.2316 0.4679
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0122 0.0171
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0149
Echinococcus multilocularis dna polymerase eta 0.0052 0.0223 0.0335
Echinococcus granulosus expressed protein 0.0027 0.0055 0.0112
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0061 0.0284 0.0889
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0107 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.0621 0.0914
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0024 0.0055
Mycobacterium tuberculosis Probable reductase 0.0071 0.0345 0.0313
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1372 0.1342
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.0862 0.1273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Echinococcus granulosus microtubule associated protein 2 0.0671 0.437 0.883
Echinococcus granulosus geminin 0.0167 0.0995 0.2009
Loa Loa (eye worm) thioredoxin reductase 0.0031 0.008 0.0109
Echinococcus multilocularis dnaJ subfamily B 0.0256 0.1591 0.2384
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0106 0.0318
Trypanosoma cruzi DNA polymerase eta, putative 0.0052 0.0223 0.0939
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0107 0.0216
Schistosoma mansoni aldehyde dehydrogenase 0.0087 0.0458 0.1049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0247 0.1527 0.6585
Loa Loa (eye worm) hypothetical protein 0.0365 0.2316 0.3437
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0117 0.0656 0.281
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0054
Brugia malayi Hemopexin family protein 0.0066 0.0314 0.0457
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0034 0.0101 0.0151
Brugia malayi mbt repeat family protein 0.003 0.0073 0.0099
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0384 0.0561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0122 0.0246
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0027 0.0055 0.0073
Loa Loa (eye worm) acyltransferase 0.0365 0.2316 0.3437
Schistosoma mansoni hypothetical protein 0.0035 0.0107 0.0245
Leishmania major hypothetical protein, conserved 0.0035 0.0107 0.0435
Schistosoma mansoni hypothetical protein 0.0024 0.0032 0.0074
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.437 1
Onchocerca volvulus 0.0046 0.0184 0.2265
Schistosoma mansoni rotamase 0.0027 0.0055 0.0127
Loa Loa (eye worm) hypothetical protein 0.0057 0.0251 0.0364
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0035 0.0105 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0122 0.0182
Trichomonas vaginalis maltase-glucoamylase, putative 0.0023 0.0024 0.0055
Brugia malayi Matrixin family protein 0.0046 0.0184 0.0263
Plasmodium vivax thioredoxin reductase, putative 0.0031 0.008 0.0316
Loa Loa (eye worm) matrixin family protein 0.0103 0.0562 0.0827
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0106 0.043
Brugia malayi EGF-like domain containing protein 0.0033 0.0093 0.0129
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0087 0.0458 0.0426
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0129
Loa Loa (eye worm) hypothetical protein 0.0041 0.0146 0.0208
Trypanosoma cruzi DNA repair protein, putative 0.0028 0.0062 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0486 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0117 0.0656 0.281
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0106 0.043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0023 0.0024 0.0055
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0034 0.0101 0.0254
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate o-acyltransferase 0.0365 0.2316 0.5299
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0073 0.0147
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0238 0.1464 0.6254
Echinococcus granulosus Niemann Pick C1 protein 0.0061 0.0284 0.0575
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0032 0.0084 0.0126
Giardia lamblia High cysteine protein 0.0033 0.0093 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0024 0.0074
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1419 0.9385 0.9383

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NT 0 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 0.25h,dose 12.5 mg/kg; No activity was demonstrated ChEMBL. 8831764
Activity (functional) NT 0 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 0.5h,dose 12.5 mg/kg; No activity was demonstrated ChEMBL. 8831764
Activity (functional) NT 0 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 1h,dose 12.5 mg/kg; No activity was demonstrated ChEMBL. 8831764
Activity (functional) NT 0 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 2h,dose 12.5 mg/kg; No activity was demonstrated ChEMBL. 8831764
Activity (functional) = 2 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 4h,dose 12.5 mg/kg; number of rats out of four which were protected ChEMBL. 8831764
Dose (functional) = 300 mg kg-1 Anticonvulsant activity after intraperitoneal injection into mice measured in a maximal electroshock scree (MES) screen ChEMBL. 8831764
Dose (functional) = 300 mg kg-1 Anticonvulsant activity after intraperitoneal injection into mice measured in a maximal electroshock scree (MES) screen ChEMBL. 8831764

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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