Detailed information for compound 233710

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.642 | Formula: C28H40N4O3
  • H donors: 4 H acceptors: 3 LogP: 4.25 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C[C@@H](C(=O)N[C@H](C(=O)NCc1ccccc1)Cc1ccccc1)NC(=O)[C@@H](CC(C)C)N)C
  • InChi: 1S/C28H40N4O3/c1-19(2)15-23(29)26(33)31-24(16-20(3)4)28(35)32-25(17-21-11-7-5-8-12-21)27(34)30-18-22-13-9-6-10-14-22/h5-14,19-20,23-25H,15-18,29H2,1-4H3,(H,30,34)(H,31,33)(H,32,35)/t23-,24+,25+/m1/s1
  • InChiKey: CLEOQVDSXZQLLG-DSITVLBTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0478 0.1031 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0095 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus notch 0.0524 0.1136 0.1136
Giardia lamblia Kinase, CMGC MAPK 0.0045 0.0039 0.0006
Brugia malayi hypothetical protein 0.1621 0.3654 0.3654
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0131 0.0235 0.0235
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0478 0.1031 0.1024
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.0132 0.1216
Plasmodium falciparum phosphodiesterase gamma, putative 0.0478 0.1031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0478 0.1031 0.1031
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0045 0.0039 0.0308
Echinococcus granulosus protein jagged 1 0.0524 0.1136 0.1136
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0478 0.1031 0.1031
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0103 0.0172 0.7317
Echinococcus multilocularis neurogenic locus notch protein 4 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi notch-like transmembrane receptor 0.0524 0.1136 0.1136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Brugia malayi Niemann-Pick C1 protein precursor 0.0094 0.015 0.015
Echinococcus granulosus neurogenic locus protein delta 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.3446 0.7843 0.7843
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0478 0.1031 0.1031
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0131 0.0235 0.0235
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0478 0.1031 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Brugia malayi Calcium binding EGF domain containing protein 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi hypothetical protein 0.0131 0.0235 0.0235
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Brugia malayi Animal haem peroxidase family protein 0.1621 0.3654 0.3654
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0524 0.1136 0.3046
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Echinococcus multilocularis neurogenic locus notch protein 0.0524 0.1136 0.1136
Echinococcus multilocularis transcription factor Dp 1 0.006 0.0072 0.0072
Echinococcus granulosus Protein patched homolog 1 0.004 0.0027 0.0027
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0225 0.0451 0.239
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0524 0.1136 0.1136
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0131 0.0235 1
Echinococcus granulosus peroxidasin 0.1621 0.3654 0.3654
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus multilocularis notch 0.0524 0.1136 0.1136
Echinococcus granulosus slit 2 protein 0.0524 0.1136 0.1136
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Echinococcus granulosus neurogenic locus notch protein 0.0524 0.1136 0.1136
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0478 0.1031 1
Schistosoma mansoni laminin gamma-3 chain 0.0524 0.1136 0.1136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0478 0.1031 0.1031
Loa Loa (eye worm) matrixin family protein 0.1436 0.323 0.3225
Schistosoma mansoni notch 0.0524 0.1136 0.1136
Echinococcus multilocularis fibropellin Ia 0.0524 0.1136 0.1136
Onchocerca volvulus 0.0131 0.0235 0.0556
Loa Loa (eye worm) hypothetical protein 0.0053 0.0056 0.0048
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0103 0.0172 0.1608
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0478 0.1031 0.1031
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.3924 0.8939 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Onchocerca volvulus Peroxidase homolog 0.1621 0.3654 1
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0131 0.0235 0.0235
Echinococcus multilocularis GPCR, family 2 0.0032 0.0007 0.0007
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0131 0.0235 0.0235
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0048 0.0045 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0034 0.0063
Onchocerca volvulus 0.0131 0.0235 0.0556
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Schistosoma mansoni hypothetical protein 0.0524 0.1136 0.1136
Trypanosoma brucei protein tyrosine phosphatase 1 0.0131 0.0235 0.2225
Echinococcus granulosus Niemann Pick C1 protein 0.0134 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Brugia malayi Blistered cuticle protein 3 0.1621 0.3654 0.3654
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0094 0.015 0.6394
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0478 0.1031 0.1024
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0043 0.0034 0.0026
Onchocerca volvulus 0.1621 0.3654 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.0648 0.1421 0.1414
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Trypanosoma brucei Polypeptide deformylase 1 0.0086 0.0132 0.1216
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.1031 1
Loa Loa (eye worm) protein tyrosine phosphatase 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Echinococcus multilocularis sterol regulatory element binding protein 0.004 0.0027 0.0027
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.3924 0.8939 0.8939
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0045 0.0039 0.0308
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0043 0.0034 0.0257
Onchocerca volvulus 0.0113 0.0195 0.0446
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Echinococcus multilocularis dedicator of cytokinesis protein 0.0042 0.0032 0.0032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Echinococcus multilocularis hypothetical protein 0.0131 0.0235 0.0235
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0131 0.0235 0.2225
Loa Loa (eye worm) blistered cuticle protein 3 0.1621 0.3654 0.3649
Onchocerca volvulus 0.0524 0.1136 0.3046
Onchocerca volvulus 0.0524 0.1136 0.3046
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.4386 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0007 0.0007
Echinococcus multilocularis protein patched 0.004 0.0027 0.0027
Loa Loa (eye worm) matrixin family protein 0.1566 0.3528 0.3523
Schistosoma mansoni notch 0.0524 0.1136 0.1136
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0103 0.0172 0.1608
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0164 0.0164
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Mycobacterium ulcerans hydrolase 0.0789 0.1745 1
Toxoplasma gondii EGF family domain-containing protein 0.0524 0.1136 0.1264
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0045 0.0039 0.0032
Loa Loa (eye worm) hypothetical protein 0.0789 0.1745 0.1739
Loa Loa (eye worm) Notch2 0.0524 0.1136 0.113
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0478 0.1031 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0103 0.0172 0.1608
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Loa Loa (eye worm) hypothetical protein 0.0648 0.1421 0.1414
Plasmodium falciparum peptide deformylase 0.0225 0.0451 0.4185
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0131 0.0235 0.0235
Brugia malayi hypothetical protein 0.0131 0.0235 0.0235
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0478 0.1031 0.1031
Schistosoma mansoni cell polarity protein 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Brugia malayi hypothetical protein 0.0131 0.0235 0.0235
Echinococcus multilocularis expressed conserved protein 0.0088 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.0132 0.1216
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0131 0.0235 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus multilocularis slit 2 protein 0.0524 0.1136 0.1136
Brugia malayi GCC2 and GCC3 family protein 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Schistosoma mansoni hypothetical protein 0.0284 0.0587 0.0587
Giardia lamblia Protein tyrosine phosphatase 0.0131 0.0235 0.0226
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0043 0.0034 0.0257
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Trypanosoma brucei protein kinase, putative 0.0043 0.0034 0.0257
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0131 0.0235 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Brugia malayi endonuclease G, mitochondrial precursor 0.0032 0.0007 0.0007
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Trypanosoma cruzi hypothetical protein, conserved 0.0478 0.1031 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0478 0.1031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Loa Loa (eye worm) hypothetical protein 0.0478 0.1031 0.1024
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.1031 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.01 0.0164 0.0157
Schistosoma mansoni peroxidasin 0.1621 0.3654 0.3654
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0478 0.1031 0.1031
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Schistosoma mansoni protein tyrosine phosphatase 0.0131 0.0235 0.0235
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Onchocerca volvulus 0.0135 0.0244 0.0582
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus multilocularis protein kinase shaggy 0.0043 0.0034 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.4386 1 1
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Onchocerca volvulus Peroxidasin homolog 0.1621 0.3654 1
Schistosoma mansoni aldehyde dehydrogenase 0.0048 0.0045 0.0045
Mycobacterium ulcerans peptide deformylase 0.0225 0.0451 0.239
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0478 0.1031 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0478 0.1031 1
Trypanosoma brucei protein kinase, putative 0.0045 0.0039 0.0308
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0034 0.1433
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0478 0.1031 0.1031
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0131 0.0235 0.0235
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0131 0.0235 0.0235
Onchocerca volvulus Peroxidase homolog 0.1621 0.3654 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0478 0.1031 0.1031
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0478 0.1031 0.1031
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0039 0.0115
Brugia malayi Thrombospondin type 1 domain containing protein 0.0113 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0045 0.0039 0.0308
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1623 0.3658 0.3658
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.2354 0.5337 0.5337
Brugia malayi Cadherin domain containing protein 0.0524 0.1136 0.1136
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0131 0.0235 0.2225
Schistosoma mansoni notch 0.0524 0.1136 0.1136
Schistosoma mansoni septate junction protein 0.0532 0.1155 0.1155
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0053 0.0056 0.0056
Onchocerca volvulus Chorion peroxidase homolog 0.1621 0.3654 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.3924 0.8939 0.8939
Trypanosoma cruzi hypothetical protein, conserved 0.0478 0.1031 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0091 0.0091
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0131 0.0235 0.0235
Echinococcus multilocularis fat cadherin tumor suppressor 0.0524 0.1136 0.1136
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0045 0.0039 0.0308
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0478 0.1031 0.1031
Echinococcus multilocularis protein dispatched 1 0.0046 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0068 0.0091 0.0084
Schistosoma mansoni survival motor neuron protein 0.0135 0.0244 0.0244
Brugia malayi Animal haem peroxidase family protein 0.1621 0.3654 0.3654
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus granulosus ectonucleotide 0.0044 0.0037 0.0037
Echinococcus multilocularis protein jagged 1 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Brugia malayi EGF-like domain containing protein 0.0524 0.1136 0.1136
Echinococcus granulosus transcription factor Dp 1 0.006 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Brugia malayi EGF-like domain containing protein 0.0524 0.1136 0.1136
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus granulosus protein kinase shaggy 0.0043 0.0034 0.0034
Brugia malayi MAP kinase sur-1 0.0045 0.0039 0.0039
Brugia malayi Peroxidasin 0.1621 0.3654 0.3654
Schistosoma mansoni hypothetical protein 0.0524 0.1136 0.1136
Brugia malayi hypothetical protein 0.0661 0.1452 0.1452
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.005 0.005 0.005
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0034 0.1433
Schistosoma mansoni aldehyde dehydrogenase 0.0048 0.0045 0.0045
Loa Loa (eye worm) animal heme peroxidase 0.1621 0.3654 0.3649
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0478 0.1031 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0131 0.0235 0.0235
Echinococcus granulosus microtubule associated protein 2 0.1381 0.3103 0.3103
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0131 0.0235 0.0235
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0439 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0131 0.0235 0.0235
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Brugia malayi EGF-like domain containing protein 0.0524 0.1136 0.1136
Onchocerca volvulus Dual oxidase homolog 0.1621 0.3654 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Echinococcus multilocularis protein jagged 1 0.0524 0.1136 0.1136
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0043 0.0034 0.0034
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0053 0.0056 0.0056
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Echinococcus multilocularis mitogen activated protein kinase 3 0.0045 0.0039 0.0039
Brugia malayi Delta serrate ligand family protein 0.0524 0.1136 0.1136
Onchocerca volvulus 0.0131 0.0235 0.0556
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.3446 0.7843 0.7841
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi Matrixin family protein 0.1566 0.3528 0.3528
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Schistosoma mansoni protein tyrosine phosphatase 0.0131 0.0235 0.0235
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0113 0.0195 0.0188
Brugia malayi CHE-14 protein 0.004 0.0027 0.0027
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Onchocerca volvulus 4.1 G protein, putative homolog 0.0131 0.0235 0.0556
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Brugia malayi Matrixin family protein 0.0648 0.1421 0.1421
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Echinococcus granulosus neurogenic locus notch protein 0.0524 0.1136 0.1136
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Loa Loa (eye worm) animal heme peroxidase 0.1621 0.3654 0.3649
Echinococcus granulosus sterol regulatory element binding protein 0.004 0.0027 0.0027
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0478 0.1031 0.1031
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0131 0.0235 0.0235
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0478 0.1031 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Echinococcus granulosus neurogenic locus notch protein 4 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Loa Loa (eye worm) animal heme peroxidase 0.1621 0.3654 0.3649
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0103 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Brugia malayi Protein-tyrosine phosphatase 1 0.0131 0.0235 0.0235
Echinococcus granulosus muscleblind protein 0.0512 0.1109 0.1109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Loa Loa (eye worm) animal heme peroxidase 0.1621 0.3654 0.3649
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Onchocerca volvulus 0.0131 0.0235 0.0556
Trypanosoma cruzi hypothetical protein, conserved 0.0478 0.1031 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0478 0.1031 0.1031
Onchocerca volvulus 0.0131 0.0235 0.0556
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0103 0.0172 0.0172
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0131 0.0235 0.0235
Onchocerca volvulus 0.0918 0.2042 0.5547
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0135 0.0244 0.0244
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) notch protein 0.0524 0.1136 0.113
Onchocerca volvulus Putative cubilin 0.0524 0.1136 0.3046
Schistosoma mansoni hypothetical protein 0.0032 0.0007 0.0007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.1031 1
Brugia malayi Muscleblind-like protein 0.0512 0.1109 0.1109
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0131 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.3924 0.8939 0.8938
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0007 0.0007
Echinococcus multilocularis survival motor neuron protein 1 0.0661 0.1452 0.1452
Schistosoma mansoni notch 0.0524 0.1136 0.1136
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0044 0.0037 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0478 0.1031 1
Onchocerca volvulus 0.0131 0.0235 0.0556
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0478 0.1031 1
Echinococcus multilocularis peroxidasin 0.1621 0.3654 0.3654
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0478 0.1031 0.1031
Echinococcus multilocularis geminin 0.0284 0.0587 0.0587
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0131 0.0235 0.0235
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0478 0.1031 0.1031
Brugia malayi hypothetical protein 0.0131 0.0235 0.0235
Loa Loa (eye worm) PDE1B protein 0.0478 0.1031 0.1024
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0131 0.0235 0.0235
Echinococcus granulosus Niemann Pick C1 protein 0.0094 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.4386 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0164 0.0157
Echinococcus granulosus protein jagged 1 0.0524 0.1136 0.1136
Giardia lamblia Hypothetical protein 0.0478 0.1031 0.112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Onchocerca volvulus 0.0648 0.1421 0.3832
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.3446 0.7843 0.7843
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0131 0.0235 0.0235
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0478 0.1031 0.1031
Loa Loa (eye worm) hypothetical protein 0.0094 0.015 0.0143
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.005 0.005 0.005
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0478 0.1031 0.1031
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Onchocerca volvulus Matrilysin homolog 0.0648 0.1421 0.3832
Schistosoma mansoni peroxidasin 0.1621 0.3654 0.3654
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0131 0.0235 0.0228
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0131 0.0235 0.0235
Onchocerca volvulus 0.0053 0.0056 0.006
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0524 0.1136 0.1136
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0478 0.1031 0.1031
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0043 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0512 0.1109 0.1103
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus multilocularis Endonuclease G 0.0032 0.0007 0.0007
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0992 0.2211 0.2211
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0478 0.1031 0.1031
Chlamydia trachomatis peptide deformylase 0.0225 0.0451 0.5
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0048 0.0045 0.0366
Leishmania major cAMP-specific phosphodiesterase, putative 0.0478 0.1031 1
Leishmania major tyrosine specific protein phosphatase, putative 0.0131 0.0235 0.2225
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3924 0.8939 0.8939
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0039 0.0115
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0478 0.1031 0.1031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Loa Loa (eye worm) hypothetical protein 0.0044 0.0037 0.0029
Plasmodium vivax peptide deformylase, putative 0.0225 0.0451 0.4185
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Onchocerca volvulus Peroxidasin homolog 0.1621 0.3654 1
Onchocerca volvulus 0.1621 0.3654 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0045 0.0039 0.0035
Brugia malayi EGF-like domain containing protein 0.0524 0.1136 0.1136
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0032 0.0007 0.0007
Echinococcus granulosus fibropellin Ia 0.0524 0.1136 0.1136
Echinococcus multilocularis neurogenic locus protein delta 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Schistosoma mansoni microtubule-associated protein tau 0.1381 0.3103 0.3103
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0648 0.1421 0.1421
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Leishmania major hypothetical protein, conserved 0.0478 0.1031 1
Brugia malayi Muscle positioning protein 4 0.0524 0.1136 0.1136
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.2354 0.5337 0.5337
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0131 0.0235 0.2225
Plasmodium falciparum phosphodiesterase delta, putative 0.0478 0.1031 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Brugia malayi Calcium binding EGF domain containing protein 0.0524 0.1136 0.1136
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0053 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0524 0.1136 0.1136
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Trypanosoma brucei Peptide deformylase 2 0.0086 0.0132 0.1216
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0131 0.0235 0.2225
Brugia malayi Calcium binding EGF domain containing protein 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Echinococcus multilocularis microtubule associated protein 2 0.1381 0.3103 0.3103
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0053 0.0056 0.0056
Leishmania major polypeptide deformylase-like protein, putative 0.0086 0.0132 0.1216
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Echinococcus granulosus protein tyrosine phosphatase n9 0.0131 0.0235 0.0235
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0478 0.1031 0.1031
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0131 0.0235 0.0228
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus granulosus mitogen activated protein kinase 0.0045 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0131 0.0235 0.0235
Brugia malayi Hemopexin family protein 0.0918 0.2042 0.2042
Schistosoma mansoni hypothetical protein 0.0135 0.0244 0.0244
Onchocerca volvulus 0.0053 0.0056 0.006
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0131 0.0235 0.0235
Schistosoma mansoni notch 0.0524 0.1136 0.1136
Onchocerca volvulus 0.0131 0.0235 0.0556
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Schistosoma mansoni endonuclease related 0.0032 0.0007 0.0007
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0103 0.0172 0.1608
Onchocerca volvulus 0.0524 0.1136 0.3046
Loa Loa (eye worm) hypothetical protein 0.004 0.0027 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0131 0.0235 0.0235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.3924 0.8939 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0103 0.0172 0.0165
Onchocerca volvulus Matrilysin homolog 0.1436 0.323 0.8831
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus granulosus protein jagged 2 0.0524 0.1136 0.1136
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3446 0.7843 0.7843
Schistosoma mansoni patched 1 0.004 0.0027 0.0027
Brugia malayi EGF-like domain containing protein 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0103 0.0172 0.0172
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Onchocerca volvulus 0.0131 0.0235 0.0556
Schistosoma mansoni hypothetical protein 0.0524 0.1136 0.1136
Entamoeba histolytica protein kinase, putative 0.0043 0.0034 0.1433
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0131 0.0235 0.0235
Echinococcus granulosus mitogen activated protein kinase 3 0.0045 0.0039 0.0039
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Echinococcus multilocularis Niemann Pick C1 protein 0.0094 0.015 0.015
Echinococcus granulosus neural cadherin 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0034 0.0063
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0131 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0024
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0478 0.1031 0.1031
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0103 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0053 0.0056 0.0048
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus multilocularis ectonucleotide 0.0044 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0043 0.0034 0.0026
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.3924 0.8939 0.8939
Brugia malayi EGF-like domain containing protein 0.0524 0.1136 0.1136
Echinococcus granulosus survival motor neuron protein 1 0.0661 0.1452 0.1452
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0053 0.0056 0.0056
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus granulosus GPCR family 2 0.0032 0.0007 0.0007
Loa Loa (eye worm) matrix metalloproteinase 0.0648 0.1421 0.1414
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0225 0.0451 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.4386 1 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0661 0.1452 0.1446
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0007 0.0007
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0131 0.0235 0.0228
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0789 0.1745 0.1745
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0131 0.0235 0.0235
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0131 0.0235 0.0235
Leishmania major hypothetical protein, conserved 0.0478 0.1031 1
Toxoplasma gondii hypothetical protein 0.0225 0.0451 0.0497
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0478 0.1031 0.1031
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Onchocerca volvulus Slit protein homolog 0.0524 0.1136 0.3046
Echinococcus granulosus protein jagged 2 0.0524 0.1136 0.1136
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0131 0.0235 0.0235
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0007 0.0007
Onchocerca volvulus Matrix metalloproteinase homolog 0.1436 0.323 0.8831
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0024
Toxoplasma gondii aldehyde dehydrogenase 0.0048 0.0045 0.0042
Echinococcus granulosus expressed conserved protein 0.0088 0.0137 0.0137
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.0478 0.1031 1
Schistosoma mansoni hypothetical protein 0.0113 0.0195 0.0195
Onchocerca volvulus 0.0524 0.1136 0.3046
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0478 0.1031 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0164 0.0164
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.004 0.0027 0.002
Echinococcus granulosus delta-like protein 1 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0512 0.1109 0.1103
Schistosoma mansoni hypothetical protein 0.0068 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0524 0.1136 0.1136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0478 0.1031 0.1146
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0131 0.0235 0.0235
Onchocerca volvulus 0.0131 0.0235 0.0556
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Onchocerca volvulus 0.0524 0.1136 0.3046
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Echinococcus multilocularis mitogen activated protein kinase 0.0045 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0648 0.1421 0.1414
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0478 0.1031 1
Schistosoma mansoni hypothetical protein 0.0918 0.2042 0.2042
Brugia malayi intracellular kinase 0.0043 0.0034 0.0034
Giardia lamblia hypothetical protein 0.0478 0.1031 0.112
Mycobacterium leprae PROBABLE HYDROLASE 0.0789 0.1745 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0045 0.0039 0.0308
Loa Loa (eye worm) hypothetical protein 0.0053 0.0056 0.0048
Brugia malayi Matrixin family protein 0.0648 0.1421 0.1421
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Onchocerca volvulus 0.0131 0.0235 0.0556
Echinococcus multilocularis protein jagged 2 0.0524 0.1136 0.1136
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0048 0.0045 0.0045
Onchocerca volvulus 0.0131 0.0235 0.0556
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.0132 0.1216
Trypanosoma cruzi hypothetical protein, conserved 0.0478 0.1031 1
Schistosoma mansoni dock 0.005 0.005 0.005
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0045 0.0039 0.0308
Echinococcus granulosus geminin 0.0284 0.0587 0.0587
Brugia malayi hypothetical protein 0.0131 0.0235 0.0235
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0478 0.1031 0.1031
Echinococcus multilocularis neurogenic locus notch protein 0.0524 0.1136 0.1136
Schistosoma mansoni notch 0.0524 0.1136 0.1136
Brugia malayi Animal haem peroxidase family protein 0.1621 0.3654 0.3654
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0044 0.0037 0.0037
Onchocerca volvulus 0.0131 0.0235 0.0556
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0131 0.0235 0.0235
Brugia malayi Animal haem peroxidase family protein 0.1621 0.3654 0.3654
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Treponema pallidum polypeptide deformylase (def) 0.0225 0.0451 0.5
Echinococcus multilocularis neural cadherin 0.0524 0.1136 0.1136
Onchocerca volvulus Neurogenic locus notch homolog 0.0524 0.1136 0.3046
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Schistosoma mansoni slit 0.0524 0.1136 0.1136
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0045 0.0039 0.0308
Brugia malayi Animal haem peroxidase family protein 0.1621 0.3654 0.3654
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0007 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0134 0.0243 0.0243
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0478 0.1031 0.1031
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Onchocerca volvulus 0.0131 0.0235 0.0556
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Loa Loa (eye worm) hypothetical protein 0.0049 0.0048 0.0041
Brugia malayi EGF-like domain containing protein 0.0524 0.1136 0.1136
Giardia lamblia High cysteine protein 0.0524 0.1136 0.1238
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0478 0.1031 0.1031
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0039 0.0115
Schistosoma mansoni hypothetical protein 0.0524 0.1136 0.1136
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0478 0.1031 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1031 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0478 0.1031 1
Brugia malayi Protein-tyrosine phosphatase 0.0131 0.0235 0.0235
Brugia malayi Matrixin family protein 0.0648 0.1421 0.1421
Schistosoma mansoni protein tyrosine phosphatase 0.0131 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Brugia malayi Matrixin family protein 0.0648 0.1421 0.1421
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0235 0.0235
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0043 0.0034 0.0034
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0478 0.1031 0.1031
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0039 0.0115
Echinococcus multilocularis 0.0131 0.0235 0.0235
Onchocerca volvulus 0.1621 0.3654 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0007 0.0007
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.0132 0.1216
Echinococcus granulosus Endonuclease G 0.0032 0.0007 0.0007
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0043 0.0034 0.0029
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0131 0.0235 0.0235
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.3924 0.8939 0.8939
Brugia malayi Protein-tyrosine phosphatase 0.0131 0.0235 0.0235
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Onchocerca volvulus 0.0131 0.0235 0.0556
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Onchocerca volvulus 0.0131 0.0235 0.0556
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Schistosoma mansoni hypothetical protein 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0131 0.0235 0.0228
Brugia malayi Cadherin domain containing protein 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Echinococcus multilocularis muscleblind protein 0.0512 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0524 0.1136 0.113
Schistosoma mansoni hypothetical protein 0.0284 0.0587 0.0587
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0478 0.1031 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0524 0.1136 0.1136
Schistosoma mansoni pcd6 interacting protein-related 0.0131 0.0235 0.0235
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0478 0.1031 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Schistosoma mansoni hypothetical protein 0.0039 0.0024 0.0024
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0053 0.0056 0.0056
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0789 0.1745 1
Echinococcus multilocularis neurogenic locus protein delta 0.0524 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.1621 0.3654 0.3649
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0235 0.0228
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0478 0.1031 0.1024
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0235 0.0235
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0131 0.0235 0.0235
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0131 0.0235 0.0235
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0478 0.1031 0.1031
Echinococcus multilocularis muscleblind protein 1 0.0512 0.1109 0.1109
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1031 1
Trichomonas vaginalis pten, drome, putative 0.0131 0.0235 0.207

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.5 uM Inhibition of human fibroblast collagenase ChEMBL. 8277511
IC50 (binding) = 0.5 uM Inhibition of human fibroblast collagenase ChEMBL. 8277511
IC50 (binding) = 10.8 uM Inhibition of human fibroblast stromelysin ChEMBL. 8277511
IC50 (binding) = 10.8 uM Inhibition of human fibroblast stromelysin ChEMBL. 8277511

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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