Detailed information for compound 254959

Basic information

Technical information
  • TDR Targets ID: 254959
  • Name: (3,4-dichlorophenyl)-[4-[(2-pyridin-4-ylethyl amino)methyl]piperidin-1-yl]methanone
  • MW: 392.322 | Formula: C20H23Cl2N3O
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)Cl)Cl)N1CCC(CC1)CNCCc1ccncc1
  • InChi: 1S/C20H23Cl2N3O/c21-18-2-1-17(13-19(18)22)20(26)25-11-6-16(7-12-25)14-24-10-5-15-3-8-23-9-4-15/h1-4,8-9,13,16,24H,5-7,10-12,14H2
  • InChiKey: KGZFQVVUVJRTRN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3,4-dichlorophenyl)-[4-[[2-(4-pyridyl)ethylamino]methyl]-1-piperidyl]methanone
  • (3,4-dichlorophenyl)-[4-[[2-(4-pyridyl)ethylamino]methyl]-1-piperidinyl]methanone
  • (3,4-dichlorophenyl)-[4-[[2-(4-pyridyl)ethylamino]methyl]piperidino]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.004 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.004 0.0047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2108 0.8358 0.8357
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0018 0.0021
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0031 0.0037
Plasmodium vivax calpain, putative 0.0019 0.0031 0.0036
Brugia malayi chromobox protein homolog 3 0.0038 0.0109 0.013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0196
Echinococcus granulosus allatostatin A receptor 0.0012 0.0004 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.004 0.0047
Brugia malayi RE15519p 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.004 0.0047
Brugia malayi Serotonin receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0102 0.0181
Schistosoma mansoni rab6-interacting 0.0019 0.0033 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0034
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.012 0.9045
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0329 0.0394
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0004 0.0005
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0 0.000000000019005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0004 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.0497 0.0492
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0005
Echinococcus granulosus pyruvate kinase 0.0037 0.0102 0.0122
Brugia malayi beta-NAC-like protein 0.0034 0.0093 0.0111
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0081 0.0145
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0038 0.0045
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0031 0.0037
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0102 0.0121
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0133 0.0236
Brugia malayi steroid hormone receptor 0.0021 0.004 0.0047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 0.8357
Echinococcus granulosus geminin 0.0352 0.1359 0.1626
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0031 0.0038
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0208 0.0248
Schistosoma mansoni cpg binding protein 0.0033 0.0089 0.0106
Schistosoma mansoni opsin-like receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0093 0.011
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0031 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0034
Echinococcus multilocularis calpain 0.0019 0.0031 0.0037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0004 0.0005
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0004 0.0005
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0031 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0004 0.0005
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0006 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0041 0.012 0.0143
Onchocerca volvulus 0.0012 0.0004 0.0261
Echinococcus multilocularis lamin 0.0026 0.0061 0.0073
Echinococcus granulosus calpain A 0.0066 0.0221 0.0264
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0029 0.0034
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0038 0.0032
Brugia malayi Serotonin receptor 0.0012 0.0004 0.0005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.0497 0.1803
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1449 0.5731 0.6845
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0066 0.006
Echinococcus granulosus calpain A 0.0019 0.0031 0.0037
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0102 0.7653
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.004 0.2956
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0004 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0245 0.0292
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0061 0.0109
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0 0.000000000019005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0012 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0004 0.0005
Echinococcus multilocularis GPCR, family 2 0.0018 0.0027 0.0033
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0038 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus granulosus GPCR family 2 0.0018 0.0027 0.0033
Brugia malayi Dopamine receptor protein 2 0.0012 0.0004 0.0005
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0221 0.0264
Onchocerca volvulus Alhambra homolog 0.0029 0.007 0.5244
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0093 0.0164
Echinococcus multilocularis pyruvate kinase 0.0037 0.0102 0.0122
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0012 0.0015
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.007 0.0083
Echinococcus multilocularis chromobox protein 1 0.0068 0.0228 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0243 0.0291
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0031 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0004 0.0005
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0004 0.0005
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0004 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0102 0.7653
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0101 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0135 0.0239
Onchocerca volvulus 0.0012 0.0004 0.0261
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1345 0.5316 0.945
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0245 0.0239
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.004 0.0047
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0102 0.0122
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0004 0.0005
Schistosoma mansoni chromobox protein 0.0068 0.0228 0.0273
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.004 0.0047
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0038
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0033 0.0039
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Trypanosoma cruzi kinesin, putative 0.0019 0.0031 0.0025
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0102 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0423 0.0751
Toxoplasma gondii exonuclease III APE 0.0021 0.0038 0.0045
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0031 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.2108 0.8358 1
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0659 0.2583 1
Schistosoma mansoni biogenic amine receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0016 0.0018
Onchocerca volvulus 0.0012 0.0004 0.0261
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0191 0.034
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0033
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0686 0.2689 0.2685
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0102 0.0096
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.252 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0004 0.0007
Leishmania major hypothetical protein, conserved 0.0028 0.0066 0.006
Brugia malayi G-protein coupled receptor 0.0012 0.0004 0.0005
Echinococcus granulosus bloom syndrome protein 0.0023 0.0049 0.0059
Schistosoma mansoni transcription factor btf3 0.0034 0.0093 0.0111
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1345 0.5316 0.945
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2108 0.8358 1
Echinococcus granulosus lamin 0.0026 0.0061 0.0073
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0066 0.006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.0497 0.0595
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0031 0.0037
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0038 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.004 0.0047
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0101 0.0121
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0004 0.0261
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0003 0.0004
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Brugia malayi Associated with TFs and helicases family protein 0.0011 0 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0027 0.0033
Echinococcus granulosus calpain 5 0.0019 0.0031 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Brugia malayi MH2 domain containing protein 0.0117 0.0423 0.0506
Schistosoma mansoni polycystin 1-related 0.0019 0.0033 0.0039
Echinococcus granulosus fmrfamide receptor 0.0012 0.0004 0.0005
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.003 0.0035
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0004 0.0007
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0686 0.2689 0.3217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0135 0.0161
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0005 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Echinococcus granulosus pyruvate kinase 0.0019 0.0031 0.0037
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0004 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0228 0.0273
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0245 0.0293
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0004 0.0005
Brugia malayi Dopamine receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis calpain A 0.0066 0.0221 0.0264
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0033
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0102 0.0181
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1345 0.5316 0.636
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0004 0.0005
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0763 0.2998 0.3587
Schistosoma mansoni thyroid hormone receptor 0.0021 0.004 0.0047
Echinococcus granulosus sex peptide receptor 0.0012 0.0004 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0004 0.0005
Onchocerca volvulus 0.0012 0.0004 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0243 0.0291
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0004 0.0005
Brugia malayi G-protein coupled receptor 0.0012 0.0004 0.0005
Onchocerca volvulus 0.0012 0.0004 0.0261
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0123 0.0147
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0061 0.0109
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0004 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0004 0.0005
Trypanosoma brucei kinesin, putative 0.0019 0.0031 0.0025
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.0497 0.0595
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Entamoeba histolytica hypothetical protein 0.0034 0.0093 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0004 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.004 0.0047
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.2108 0.8358 1
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Onchocerca volvulus 0.0012 0.0004 0.0261
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0102 0.0122
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0102 0.0096
Echinococcus multilocularis geminin 0.0352 0.1359 0.1626
Schistosoma mansoni lamin 0.0026 0.0061 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0034
Loa Loa (eye worm) hypothetical protein 0.0063 0.0208 0.0369
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0004 0.0005
Echinococcus multilocularis RUN 0.0019 0.0033 0.0039
Brugia malayi AKH receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0117
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0102 0.0096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.004 0.0047
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0004 0.0005
Echinococcus granulosus dnaJ subfamily B 0.0449 0.1744 0.2087
Echinococcus granulosus somatostatin receptor 0.0012 0.0004 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0029 0.007 0.0083
Brugia malayi calpain 7 0.0019 0.0031 0.0037
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0004 0.0005
Onchocerca volvulus 0.0019 0.0033 0.2456
Loa Loa (eye worm) hypothetical protein 0.0063 0.0208 0.0369
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0039
Echinococcus granulosus microtubule associated protein 2 0.1354 0.5352 0.6404
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.089 0.3502 0.419
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0182 0.0218
Schistosoma mansoni amine GPCR 0.0012 0.0004 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0054
Schistosoma mansoni hypothetical protein 0.0449 0.1744 0.2087
Schistosoma mansoni lipoxygenase 0.0019 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0221 0.0264
Schistosoma mansoni cpg binding protein 0.0032 0.0081 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0066 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni amine GPCR 0.0012 0.0004 0.0005
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Echinococcus granulosus peregrin 0.0029 0.007 0.0083
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0172 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0159 0.059 0.1049
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0 0.0001
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2108 0.8358 0.8357
Brugia malayi Protein cec-1. 0.0011 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.004 0.0047
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.004 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Brugia malayi Bromodomain containing protein 0.0029 0.007 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.004 0.0047
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0004 0.0005
Schistosoma mansoni lipoxygenase 0.0054 0.0172 0.0205
Schistosoma mansoni hypothetical protein 0.0039 0.0111 0.0132
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0038 0.0045
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.004 0.2956
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0243 0.0291
Brugia malayi neuropeptide F receptor 0.0012 0.0004 0.0005
Plasmodium falciparum pyruvate kinase 0.0037 0.0102 0.0121
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0007 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0004 0.0005
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0221 0.0264
Onchocerca volvulus 0.0012 0.0004 0.0261
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0033 0.0039
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0102 0.7653
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0134
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 0.8357
Brugia malayi Doublecortin family protein 0.0019 0.0033 0.0039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0076
Onchocerca volvulus 0.0012 0.0004 0.0261
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0182 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.004 0.0047
Echinococcus multilocularis transcription factor btf3 0.0034 0.0093 0.0111
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0004 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0021 0.004 0.0047
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0049 0.0059
Entamoeba histolytica hypothetical protein 0.0011 0 0.000000000019005
Schistosoma mansoni neuropeptide receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) calpain 5 0.0019 0.0031 0.0055
Brugia malayi CHD4 protein 0.0013 0.0008 0.0009
Trypanosoma brucei antigen, putative 0.0019 0.0031 0.0025
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0004 0.0005
Schistosoma mansoni chromobox protein 0.0068 0.0228 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.004 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.004 0.007
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0031 0.0025
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0058 0.0068
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0172 0.0205
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0031 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0133 0.0159
Onchocerca volvulus 0.0012 0.0004 0.0261
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.2108 0.8358 1
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0423 0.0751
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0102 0.0096
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0038 0.0068
Schistosoma mansoni adenoreceptor 0.0012 0.0004 0.0005
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0228 0.0406
Echinococcus granulosus g protein coupled receptor 0.0012 0.0004 0.0005
Echinococcus granulosus orexin receptor type 2 0.0012 0.0004 0.0005
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0031 0.0036
Leishmania major kinesin, putative 0.0019 0.0031 0.0025
Brugia malayi Dopamine receptor protein 1 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi jmjC domain containing protein 0.0094 0.0329 0.0394
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0004 0.0005
Schistosoma mansoni histamine h1 receptor 0.0012 0.0004 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.004 0.0047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.004 0.0047
Brugia malayi ORL1-like opioid receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.004 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.004 0.0047
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.004 0.0047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0004 0.0005
Loa Loa (eye worm) RecQ helicase 0.0023 0.0049 0.0087
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0102 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Schistosoma mansoni cpg binding protein 0.0033 0.0089 0.0106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0181
Plasmodium falciparum phd finger protein, putative 0.0029 0.007 0.0083
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0245 0.0239
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0033 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0115 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.004 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.004 0.0047
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Echinococcus multilocularis calpain 5 0.0019 0.0031 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0135 0.0161
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0004 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0135 0.0161
Schistosoma mansoni neuropeptide receptor 0.0012 0.0004 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0031 0.0025
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0004 0.0007
Giardia lamblia Pyruvate kinase 0.0037 0.0102 0.0085
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0033 0.0039
Echinococcus multilocularis cpg binding protein 0.0033 0.0089 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0135 0.0161
Leishmania major pyruvate kinase 0.0037 0.0102 0.0096
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0033 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0038 0.0045
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0031 0.0037
Entamoeba histolytica protein kinase, putative 0.0019 0.0031 0.0036
Schistosoma mansoni loxhd1 0.0019 0.0033 0.0039
Onchocerca volvulus 0.0032 0.0081 0.612
Schistosoma mansoni nuclear hormone receptor 0.0021 0.004 0.0047
Onchocerca volvulus 0.0012 0.0004 0.0261
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0031 0.0036
Echinococcus multilocularis pyruvate kinase 0.0019 0.0031 0.0037
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.007 0.0083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0004 0.0005
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0004 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.004 0.0047
Echinococcus multilocularis musashi 0.0026 0.0061 0.0073
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0004 0.0005
Brugia malayi CXXC zinc finger family protein 0.0032 0.0081 0.0097
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1345 0.5316 0.636
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0031 0.0025
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0038 0.0032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.004 0.0047
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0004 0.0005
Schistosoma mansoni lamin 0.0026 0.0061 0.0073
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0093 0.0087
Echinococcus granulosus intermediate filament protein 0.0026 0.0061 0.0073
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0049 0.0058
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0031 0.0025
Echinococcus multilocularis serotonin receptor 0.0159 0.059 0.0706
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0228 0.0273
Echinococcus granulosus transcription factor btf3 0.0034 0.0093 0.0111
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0245 0.0239
Echinococcus multilocularis somatostatin receptor 0.0012 0.0004 0.0005
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.2108 0.8358 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0252 0.0302
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.031 0.1193 0.2121
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1345 0.5316 0.636
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0245 0.0292
Loa Loa (eye worm) calpain 0.0019 0.0031 0.0055
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0004 0.0005
Brugia malayi larval opioid receptor 0.0012 0.0004 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0031 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0066 0.0079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0222 0.0266
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0038 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0243 0.0291
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.2108 0.8358 0.8357
Brugia malayi ecdysteroid receptor 0.0021 0.004 0.0047
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0004 0.0007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0243 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0109 0.0129
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0027 0.0033
Schistosoma mansoni intermediate filament proteins 0.0026 0.0061 0.0073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0 0.000000000019005
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2108 0.8358 0.8357
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0093 0.0087
Schistosoma mansoni pyruvate kinase 0.0037 0.0102 0.0122
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0109
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0004 0.0005
Echinococcus granulosus muscleblind protein 0.031 0.1193 0.1428
Onchocerca volvulus 0.0044 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0058
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2108 0.8358 0.8357
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2108 0.8358 1
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.0497 0.0594
Echinococcus multilocularis sex peptide receptor 0.0012 0.0004 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0497 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0057 0.0182 0.0324
Onchocerca volvulus 0.003 0.0076 0.5677
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0102 0.0121
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0686 0.2689 0.2685
Echinococcus granulosus g protein coupled receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Schistosoma mansoni hypothetical protein 0.0352 0.1359 0.1626
Loa Loa (eye worm) helicase 0.0011 0 0.0001
Echinococcus granulosus jumonji domain containing protein 0.004 0.0115 0.0137
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0004 0.0005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0243 0.0433
Echinococcus granulosus cpg binding protein 0.0033 0.0089 0.0106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0135 0.0161
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0031 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.004 0.0047
Echinococcus granulosus FTZ F1 alpha 0.0021 0.004 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0 0.000000000019005
Brugia malayi Melatonin receptor type 1A 0.0012 0.0004 0.0005
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0004 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0101 0.0121
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0 0.000000000019005
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0004 0.0005
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis pyruvate kinase 0.0029 0.0071 0.0085
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0093 0.011
Brugia malayi hypothetical protein 0.0028 0.0066 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0102 0.025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0027 0.0033
Echinococcus multilocularis chromobox protein 1 0.0068 0.0228 0.0273
Echinococcus granulosus g protein coupled receptor 0.0012 0.0004 0.0005
Onchocerca volvulus 0.0019 0.0033 0.2456
Schistosoma mansoni biogenic amine receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis pyruvate kinase 0.0037 0.0102 0.0122
Schistosoma mansoni ap endonuclease 0.0021 0.0038 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0093 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0004 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.004 0.0047
Brugia malayi calpain family protein 1 0.0063 0.0208 0.0249
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.004 0.0047
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0 0.000000000019005
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0245 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.0124
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0027 0.0033
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.2108 0.8358 1
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis microtubule associated protein 2 0.1354 0.5352 0.6404
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.004 0.0047
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0005
Schistosoma mansoni myosin xvIII 0.0012 0.0004 0.0005
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.252 1 1
Schistosoma mansoni neuropeptide receptor 0.0012 0.0004 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.004 0.0047
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0109 0.8169
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0004 0.0005
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi Muscleblind-like protein 0.031 0.1193 0.1428
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0027 0.0033
Onchocerca volvulus 0.0021 0.004 0.2956
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0659 0.2583 1
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0004 0.0005
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0008 0.0009
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0 0.000000000019005
Brugia malayi sulfakinin receptor protein 0.0012 0.0004 0.0005
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0004 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.004 0.0047
Onchocerca volvulus 0.0012 0.0004 0.0261
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.004 0.2956
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.004 0.0047
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1422 0.5625 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0004 0.0005
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.2108 0.8358 1
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0031 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0101 0.0179
Brugia malayi GnHR receptor homolog 0.0012 0.0004 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0027 0.0033
Echinococcus granulosus chromobox protein 1 0.0068 0.0228 0.0273
Brugia malayi TAR-binding protein 0.0072 0.0243 0.0291
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0497 0.0595
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0497 0.0552
Schistosoma mansoni opsin-like receptor 0.0012 0.0004 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.004 0.0047
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0004 0.0007
Onchocerca volvulus 0.0026 0.0061 0.4598
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0066 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.004 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi nuclear receptor NHR-88 0.0021 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni ap endonuclease 0.0021 0.0038 0.0045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.004 0.0047
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0058 0.0102
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0094 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0004 0.0005
Leishmania major pyruvate kinase 0.0037 0.0102 0.0096
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0006
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0005 0.0006
Schistosoma mansoni amine GPCR 0.0012 0.0004 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0004 0.0007
Schistosoma mansoni amine GPCR 0.0012 0.0004 0.0005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0007 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0038 0.0009
Onchocerca volvulus 0.0012 0.0004 0.0261
Brugia malayi intermediate filament protein 0.0026 0.0061 0.0073
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0245 0.0292
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0004 0.0005
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0245 0.0292
Schistosoma mansoni microtubule-associated protein tau 0.1354 0.5352 0.6404
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2108 0.8358 0.8357
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0008 0.0009
Echinococcus granulosus calpain 0.0019 0.0031 0.0037
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0034
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.007 0.0083
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0243 0.0291
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2108 0.8358 1
Brugia malayi Valyl-tRNA synthetase 0.0011 0 0.0001
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.2108 0.8358 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0093 0.011
Brugia malayi jmjC domain containing protein 0.0036 0.0101 0.0121
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0111 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.004 0.0047
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0004 0.0005
Echinococcus granulosus lamin dm0 0.0026 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0004 0.0005
Schistosoma mansoni rab6-interacting 0.0019 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.252 1 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1345 0.5316 0.636
Brugia malayi neuropeptide F receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0034
Echinococcus multilocularis hypothetical protein 0.0019 0.0031 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.031 0.1193 0.2121
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0066 0.0079
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.007 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0497 0.0552
Schistosoma mansoni calpain (C02 family) 0.0019 0.0031 0.0037
Echinococcus multilocularis pyruvate kinase 0.0019 0.0031 0.0037
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0102 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0135 0.0161
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.004 0.0047
Schistosoma mansoni pyruvate kinase 0.0037 0.0102 0.0122
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0038 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0011 0 0.000000000019005
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0208 0.0369
Leishmania major basic transcription factor 3a, putative 0.0034 0.0093 0.0087
Onchocerca volvulus 0.0012 0.0004 0.0261
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Schistosoma mansoni amine GPCR 0.0012 0.0004 0.0005
Schistosoma mansoni pyruvate kinase 0.0019 0.0031 0.0037
Echinococcus granulosus pyruvate kinase 0.0019 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Onchocerca volvulus 0.0012 0.0004 0.0261
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.2108 0.8358 1
Giardia lamblia PHD finger protein 15 0.0029 0.007 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.004 0.0047
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.1345 0.5316 0.945
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0004 0.0005
Brugia malayi hypothetical protein 0.0019 0.0033 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0024 0.0029
Brugia malayi putative neuropeptide receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0182 0.0324
Brugia malayi G protein-coupled receptor 0.0012 0.0004 0.0005
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 1
Schistosoma mansoni hypothetical protein 0.0352 0.1359 0.1626
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0058 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Echinococcus multilocularis lamin dm0 0.0026 0.0061 0.0073
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0012
Echinococcus granulosus pyruvate kinase 0.0037 0.0102 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 0.8357
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni neuropeptide receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.004 0.0047
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0033 0.0058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Brugia malayi nuclear hormone receptor 0.0021 0.004 0.0047
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0004 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.004 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0243 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0105
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2108 0.8358 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0033 0.0039
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.1744 0.2087
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0123 0.0147
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2108 0.8358 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0686 0.2689 0.2685
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0029 0.0034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.004 0.0047
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0329 0.0394
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0061 0.0073
Echinococcus granulosus tar DNA binding protein 0.0072 0.0243 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.004 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.004 0.0047
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0686 0.2689 0.2685
Brugia malayi hypothetical protein 0.0012 0.0004 0.0005
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0033 0.0039
Onchocerca volvulus 0.0012 0.0003 0.0207
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0004 0.0007
Schistosoma mansoni biogenic amine receptor 0.0012 0.0004 0.0005
Brugia malayi hypothetical protein 0.0018 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2108 0.8358 1
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis pyruvate kinase 0.0019 0.0031 0.0037
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0004 0.0005
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2108 0.8358 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0027 0.0049
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0093 0.011
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2108 0.8358 0.8357
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0033 0.0039
Echinococcus granulosus neuropeptide receptor 0.0012 0.0004 0.0005
Brugia malayi Heterochromatin protein 1 0.0068 0.0228 0.0273
Schistosoma mansoni coup transcription factor 0.0021 0.004 0.0047
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0008 0.0009
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0133 0.0236
Schistosoma mansoni opsin-like receptor 0.0012 0.0004 0.0005
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.004 0.0047
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0008 0.0013
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0038 0.0045
Loa Loa (eye worm) hypothetical protein 0.0049 0.0151 0.0269
Brugia malayi calpain family protein 1 0.0063 0.0208 0.0249
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0763 0.2998 0.3586
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0686 0.2689 0.2685
Brugia malayi SET domain containing protein 0.0012 0.0003 0.0004
Echinococcus granulosus RUN 0.0019 0.0033 0.0039
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0004 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0135 0.0161
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2108 0.8358 0.8357
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0221 0.0264
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0016 0.0018
Onchocerca volvulus 0.0012 0.0004 0.0261
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi hypothetical protein 0.0011 0 0.0001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0004 0.0005
Echinococcus granulosus serotonin receptor 0.0012 0.0004 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma cruzi kinesin, putative 0.0019 0.0031 0.0025
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0006 0.0006
Echinococcus multilocularis peregrin 0.0029 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.059 0.0706
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2108 0.8358 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.007
Onchocerca volvulus 0.0012 0.0004 0.0261
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0093 0.0087
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0005
Brugia malayi hypothetical protein 0.0019 0.0033 0.0039
Echinococcus granulosus neuropeptide receptor 0.0012 0.0004 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0243 0.0291
Onchocerca volvulus 0.0012 0.0004 0.0261
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0004 0.0005
Brugia malayi PHD-finger family protein 0.0029 0.007 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0044 0.0133 0.0236
Loa Loa (eye worm) hypothetical protein 0.0159 0.059 0.1049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0008
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0 0.000000000019005
Echinococcus granulosus chromobox protein 1 0.0068 0.0228 0.0273
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.004 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0004 0.0005
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0004 0.0007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0004 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.004 0.007
Loa Loa (eye worm) RNA binding protein 0.0072 0.0243 0.0433
Echinococcus granulosus hypothetical protein 0.0012 0.0004 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0093 0.011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0004 0.0005
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0093 0.011
Onchocerca volvulus 0.0026 0.0061 0.4598
Loa Loa (eye worm) hypothetical protein 0.0038 0.0109 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0109 0.0129
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0135 0.0161
Brugia malayi calpain 5 0.0019 0.0031 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0041 0.012 0.0143
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0004 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0497 0.0595
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0194 0.0231
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0049 0.0059
Brugia malayi RNA binding protein 0.0072 0.0243 0.0291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.007 0.0083
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0102 0.0121
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.004 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0038 0.0032
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0245 0.0239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0004 0.0005
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0004 0.0005
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1422 0.5625 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.059 0.0706
Echinococcus multilocularis serotonin receptor 0.0159 0.059 0.0706
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2108 0.8358 0.8357
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0049 0.0058
Echinococcus multilocularis muscleblind protein 1 0.031 0.1193 0.1428
Echinococcus multilocularis muscleblind protein 0.031 0.1193 0.1428
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0004 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.004 0.0047
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0038 0.0045
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.2108 0.8358 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0066 0.0079

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) < -6 Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand ChEMBL. 9836623
Log Ki (binding) < 6 Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand ChEMBL. 9836623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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